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https://www.readbyqxmd.com/read/27716591/tace-combined-with-dendritic-cells-and-cytokine-induced-killer-cells-in-the-treatment-of-hepatocellular-carcinoma-a-meta-analysis
#1
Guangzhi He, Chenhong Zheng, Huiping Huo, Huiming Zhang, Zhiquan Zhu, Junlai Li, Hongpeng Zhang
Patients with hepatocellular carcinoma (HCC), a fatal cancer, have benefited significantly from TACE (transcatheter arterial chemoembolization) and immunotherapy treatments. Immunotherapy that includes dendritic cells and cytokine-induced killer cells (DC-CIK) in combination with TACE has been extensively applied in cases of HCC. Few decisive conclusions about these combined effects on the outcomes of HCC patients have been reached. Therefore, the present meta-analysis was performed to compare the efficacy of the combined usage of DC-CIK with TACE with a TACE therapy alone on the outcomes of HCC patients...
October 4, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27602134/influence-of-autologous-dendritic-cells-on-cytokine-induced-killer-cell-proliferation-cell-phenotype-and-antitumor-activity-in-vitro
#2
Jingsong Cao, Cong Chen, Yuhuan Wang, Xuecheng Chen, Zeying Chen, Xiaoling Luo
Dendritic cell (DCs) are essential antigen processing and presentation cells that play a key role in the immune response. In this study, DCs were co-cultured with cytokine-induced killer cells (DC-CIKs) in vitro to detect changes in cell proliferation, cell phenotype and cell cytotoxicity. The results revealed that the DCs were suitable for co-culture with CIKs at day 7, and that cell quantity of DC-CIKs was lower than that of CIKs until day 11, but it was significantly improved to 1.17-fold that of CIKs at day 13...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27531774/-analysis-of-clinical-feature-and-curative-efficacy-of-30-patients-with-t-cell-lymphoblastic-lymphoma
#3
Ping Yang, Wei Zhao, Hong-Mei Jing, Kai Hu, Wei Wan, Ji-Jun Wang, Xiao-Yan Ke
OBJECTIVE: To analyze clinical feature and curative efficacy of patients with T cell lymphoblastic lymphoma(T-LBL). METHODS: The clinical data including clinical features, laboratorial results, survival and prognostic factors from 30 patients with T-LBL were retrospectively analyzed. RESULTS: Median age of 30 cases was 24.5 years, 25 (83.3%) patients were at high-intermediate and high risk by IPI, extranodal disease was present in 73.3% of the patients, 17(56...
August 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27524915/efficacy-and-safety-of-cord-blood-derived-dendritic-cells-plus-cytokine-induced-killer-cells-combined-with-chemotherapy-in-the-treatment-of-patients-with-advanced-gastric-cancer-a-randomized-phase-ii-study
#4
Ying Mu, Wei-Hua Wang, Jia-Ping Xie, Ying-Xin Zhang, Ya-Pei Yang, Chang-Hui Zhou
BACKGROUND: Cellular immunotherapy has been widely used in the treatment of solid tumors. However, the clinical application of cord blood-derived dendritic cells and cytokine-induced killer cells (CB-DC-CIK) for the treatment of gastric cancer has not been frequently reported. In this study, the efficacy and safety of CB-DC-CIK for the treatment of gastric cancer were evaluated both in vitro and in vivo. METHODS: The phenotypes, cytokines, and cytotoxicity of CB-DC-CIK were detected in vitro...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27508015/immunotherapy-with-dendritic-cells-and-cytokine-induced-killer-cells-for-mda-mb-231-breast-cancer-stem-cells-in-nude-mice
#5
Qiang Chen, Xiao-Xu Cui, Pei-Fen Liang, Jin-Xia Dou, Zi-Yan Liu, Wen-Wen Sun
OBJECTIVE: To compare the effects and safety of immunotherapy using different methods to load DC-CIK cells for MDA-MB-231 breast cancer stem cells. METHODS: A breast cancer model was established in BALB/c nude mice using breast cancer stem cells. All mice were randomly divided into six groups, and each group had three nude mice: the blank control group, the DC-CIK group (group D), the MDA-MB-231 CSC whole-cell lysate DC-CIK group (group L-D), the MDA-MB-231 CSC RNA DC-CIK group (group R-D), the THP DC-CIK group (group T-D) and group THP...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27436839/the-efficacy-of-cik-based-immunotherapies-for-advanced-solid-tumors
#6
Hongjin Chu, Fengcai Du, Lixin Jiang, Zhixin Wang, Zhaohua Gong, Peiwen Lian, Peng Li, Jian Chen
OBJECTIVE: To investigate the efficacy of cytokine-induced killer cell-based immunotherapies in patients with advanced malignant solid tumors and the difference in clinical efficiency among 3 kinds of cytokine-induced killer cell-based immunotherapies. METHODS: One hundred forty-six cases with advanced solid tumor, 230 cycles of cytokine-induced killer cell-based immunotherapies, were involved in this study. T-lymphocyte subsets, carcinoembryonic antigen, and adverse reactions were recorded...
July 19, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27421742/effectiveness-and-safety-of-chemotherapy-combined-with-cytokine-induced-killer-cell-dendritic-cell-cytokine-induced-killer-cell-therapy-for-treatment-of-gastric-cancer-in-china-a-systematic-review-and-meta-analysis
#7
Ying Mu, Chang-Hui Zhou, Shuang-Feng Chen, Jie Ding, Ying-Xin Zhang, Ya-Pei Yang, Wei-Hua Wang
BACKGROUND: Currently, cytokine-induced killer cells (CIK)/dendritic cell (DC)-CIK-mediated immunotherapy is widely used to treat gastric cancer. However, limited information regarding clinical trials on CIK/DC-CIK therapy is available. Therefore, systemic evaluation of the efficacy and safety of the combination therapy is necessary. METHODS: A meta-analysis involving 1735 patients with gastric cancer was conducted. Before analysis, the study quality and heterogeneity were evaluated...
September 2016: Cytotherapy
https://www.readbyqxmd.com/read/27410037/dendritic-cell-immunotherapy-combined-with-cytokine-induced-killer-cells-effectively-suppresses-established-hepatocellular-carcinomas-in-mice
#8
Nam-Chul Jung, Jun-Ho Lee, Hyun-Ji Choi, Sung-Uk Hwang, Jie-Young Song, Han Geuk Seo, Jinjung Choi, Sang Youn Jung, Sung Gu Han, Dae-Seog Lim
BACKGROUND: The response of hepatocellular carcinoma (HCC) to immunotherapy is often disappointing and new strategies are clearly needed. The aim of the present study was to investigate whether cytokine-induced killer (CIK) cells combined with a dendritic cell vaccination enhanced cytotoxicity against hepatocarcinoma tumor cells in an in vivo animal model. METHODS: CIKs and DCs were prepared from C3H/HeJ mice by conventional methods, the dendritic cell (DC) pulsed with a MH134 cell lysate, DC or CIK alone were used as controls...
August 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27215078/the-efficacy-and-safety-of-dendritic-cells-co-cultured-with-cytokine-induced-killer-cell-therapy-in-combination-with-tace-predominant-minimally-invasive-treatment-for-hepatocellular-carcinoma-a-meta-analysis
#9
Yingying Su, Yanming Yang, Yue Ma, Yangyu Zhang, Wenwang Rao, Guang Yang, Changgui Kou
BACKGROUND: To evaluate the efficacy and safety of dendritic cells (DCs) co-cultured with cytokine-induced killer cell (CIK) immunotherapy combined with transcatheter arterial chemoembolization (TACE) or TACE plus local ablation therapy for hepatocellular carcinoma (HCC). METHODS: Our meta-analysis included a comprehensive search for relevant studies published through December 12, 2014. We used Cochrane Library, PubMed, CBM, VIP, CNKI, and Wanfang data. Depending on the heterogeneity among the included studies, we calculated the pooled odds ratio (OR) and mean difference (MD) using fixed- or random-effects models...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27173208/anti-tumor-activity-of-dendritic-cell-cytokine-induced-killer-cells-dc-ciks-sensitized-to-her2-against-her-positive-breast-cancer-cells
#10
Y Y Wen, X S Hu
This study aimed to investigate the cytotoxicity of cytokine-induced killer cells (CIKs) and Her2 epitope peptide-sensitized dendritic cells (DCs), when co-cultured with Her2-positive MCF-7 cells. DCs were separated from the Her epitope peptide-sensitized peripheral blood; the Her epitope combines directly with the MHC-II molecule on the DC surface. The DCs were co-cultured with autologous CIKs. Lactate dehydrogenase (LDH) and ELISA kits were used to detect cytotoxicity of CIKs against MCF-7 breast cancer cells; IL-12 and IFN-γ levels were also analyzed in the supernatant of the culture medium...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27143262/increasing-the-immune-activity-of-exosomes-the-effect-of-mirna-depleted-exosome-proteins-on-activating-dendritic-cell-cytokine-induced-killer-cells-against-pancreatic-cancer
#11
Ri-Sheng Que, Cheng Lin, Guo-Ping Ding, Zheng-Rong Wu, Li-Ping Cao
BACKGROUND: Tumor-derived exosomes were considered to be potential candidates for tumor vaccines because they are abundant in immune-regulating proteins, whereas tumor exosomal miRNAs may induce immune tolerance, thereby having an opposite immune function. OBJECTIVE: This study was designed to separate exosomal protein and depleted exosomal microRNAs (miRNAs), increasing the immune activity of exosomes for activating dendritic cell/cytokine-induced killer cells (DC/CIKs) against pancreatic cancer (PC)...
May 2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27141355/upregulation-of-pd-l1-by-eml4-alk-fusion-protein-mediates-the-immune-escape-in-alk-positive-nsclc-implication-for-optional-anti-pd-1-pd-l1-immune-therapy-for-alk-tkis-sensitive-and-resistant-nsclc-patients
#12
Shaodong Hong, Nan Chen, Wenfeng Fang, Jianhua Zhan, Qing Liu, Shiyang Kang, Xiaobo He, Lin Liu, Ting Zhou, Jiaxing Huang, Ying Chen, Tao Qin, Yaxiong Zhang, Yuxiang Ma, Yunpeng Yang, Yuanyuan Zhao, Yan Huang, Li Zhang
Driver mutations were reported to upregulate programmed death-ligand 1 (PD-L1) expression. However, how PD-L1 expression and immune function was affected by ALK-TKIs and anti-PD-1/PD-L1 treatment in ALK positive non-small-cell lung cancer (NSCLC) remains poorly understood. In the present study, western-blot, real-time PCR, flow cytometry and immunofluorescence were employed to explore how PD-L1 was regulated by ALK fusion protein. ALK-TKIs and relevant inhibitors were used to identify the downstream signaling pathways involved in PD-L1 regulation...
March 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27073525/dendritic-cell-vaccine-and-cytokine-induced-killer-cell-therapy-for-the-treatment-of-advanced-non-small-cell-lung-cancer
#13
Lihong Zhang, Xuejing Yang, Zhen Sun, Jiali Li, Hui Zhu, Jing Li, Yan Pang
The present study aimed to evaluate the survival time, immune response and safety of a dendritic cell (DC) vaccine and cytokine-induced killer (CIK) cell therapy (DC-CIK) in advanced non-small cell lung cancer (NSCLC). The present retrospective study enrolled 507 patients with advanced NSCLC; 99 patients received DC-CIK [immunotherapy group (group I)] and 408 matched patients did not receive DC-CIK, and acted as the control [non-immunotherapy group (group NI)]. Delayed-type hypersensitivity (DTH), quality of life (QOL) and safety were analyzed in group I...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/26913419/-comparison-of-several-optimization-schemes-for-the-induction-and-expansion-of-antibody-mediated-high-efficiency-cik-amhe-cik-in-vitro
#14
COMPARATIVE STUDY
Xue Yin, Xin Xu, Yao Zhao, Zhan-Ju Wang, Hai-Ying Wang, Zhen-Bo Hu
OBJECTIVE: To compare several schemes of inducing and expanding the antibody-mediated high efficiency CIK (AMHE-CIK) in vitro, so as to find out a method that can acquire a large number of cells capable to kill the tumor cells in a short time. METHODS: Peripheral blood mononuclear cells (PBMNC) from healthy volunteers was isolated and activated with CD3 antibody, then were cultured with the addition of different cytokines (IL-2, IL-4, G-CSF, GM-CSF, IFN-γ, TNF-α) for 14 days in vitro...
February 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26913407/-clinical-efficacy-of-dendritic-cells-and-cytokine-induced-killer-cells-combined-with-chemotherapy-for-treating-newly-diagnosed-multiple-myeloma-and-their-effect-on-function-of-cd4-cd25-t-cells-in-peripheral-blood
#15
RANDOMIZED CONTROLLED TRIAL
Xia Zhao, Hui-Fang Ding, Min Xu, Jian Xing, Guang Lu, Liang Wang, Guo-Qiang Liu
OBJECTIVE: To investigate the efficacy of dendritic cells and cytokine-induced killer cells (DC-CIK) combined with chemotherapy for treating newly diagnosed patients with multiple myeloma (MM) and their effect on cellular immune functions of CD4(+) CD25(+) Treg cells in peripheral blood after adoptive immunotherapy. METHODS: Fouty two patients with MM were randomly divided into two groups: chemotherapy group and combined therapy group; 20 patients in chemotherapy group were treated by chemotherapy only, 22 patients in combined therapy group were treated by adoptive immunotherapy (DC-CIK) combined with chemotherapy, and the clinical outcomes of patients and the levels of CD4(+) CD25(+) Treg cells in peripheral blood between 2 groups were compared...
February 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26708885/-effect-of-immunotherapy-of-dendritic-cells-and-cytokine-induced-killer-cells-combined-with-chemotherapy-on-secreting-function-of-t-lymphocytes-in-patients-with-multiple-myeloma
#16
RANDOMIZED CONTROLLED TRIAL
Xia Zhao, Hui-Fang Ding, Juan Liu, Guo-Qiang Liu, Min Xu, Jian Xing, Cai-Feng Sun
OBJECTIVE: To evaluate the treatment value of adoptive immunotherapy (dendritic cells and cytokine-induced killer cells, DC-CIK) combined with chemotherapy on patients with multiple myeloma (MM) and its effect on secreting function of T lymphocytes in MM patients. METHODS: A total of 36 patients with MM were randomly divided into two groups, among them 28 patients in chemotherapy group were treated by chemotherapy only, 28 patients in combined therapy group were treated by adoptive immunotherapy (DC-CIK) combined with chemotherapy, and the clinical outcomes and the levels of IL-2, IFN-γ, IL-4, IL-10 secreted by T lymphocytes between two groups were compared...
December 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26565954/primary-analysis-for-clinical-efficacy-of-immunotherapy-in-patients-with-pancreatic-cancer
#17
Linghua Chen, Xiaoyan Zhang
AIMS: Immunotherapy is an important treatment for pancreatic cancer (PC) patients. To evaluate the therapeutic efficacy of immunotherapy in the treatment of PC, we performed a systemic review and meta-analysis of the relevant published clinical trials, collectively referred to as DC, DC-CIK, LAK, NK and GM-CSF secreting PC cell lines. MATERIALS & METHODS:  A total of 413 patients in 11 eligible trials with PC were selected for the present meta-analysis. RESULTS: The estimated pooled overall survival showed a significant improvement for PC patients who received immunotherapy compared with nonimmunotherapy...
February 2016: Immunotherapy
https://www.readbyqxmd.com/read/26550444/meta-analysis-of-chemotherapy-and-dendritic-cells-with-cytokine-induced-killer-cells-in-the-treatment-of-non-small-cell-lung-cancer
#18
Chenhong Zheng, Ganjun Yu, Hui Wang, Airong Tang, Peiliang Geng, Huiming Zhang, Zhiquan Zhu, Fang Li, Xiaohua Xie
BACKGROUND: Non-small-cell lung cancer (NSCLC) is one of the most fatal cancers, which leads to large number of people dead. Followed by surgery, chemotherapy and radiotherapy, chemotherapy combined dendritic cells with cytokine-induced killer cells (DC-CIK) immunotherapy has been applied in NSCLC for some time, but little consistent beneficial results are provided. So, it is essential to weigh the pros and cons of the new therapeutic method. METHODS: We searched the randomized controlled trials of NSCLC mainly by PubMed database...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26535634/biological-activity-of-cytotoxic-dendritic-cells-cocultured-with-cytokine-induced-killer-cells-and-their-effect-on-acute-leukemia-cells
#19
X Y Cheng, J L Li
We cocultured cytokine-induced killer (CIK) cells with dendritic cells (DCs) in vitro and investigated their proliferation, immunophenotype changes, secretory cytokine levels, and their antitumor effects on acute myeloid leukemia (AML) cells. DCs and CIK cells were acquired from healthy human peripheral blood mononuclear cells and cocultured as an experimental group, while CIK cells were cultured alone as a control group. Cell numbers were counted by trypan blue staining, cytotoxic activity was measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cell phenotypes were detected by flow cytometry, and secreted levels of INF-γ and IL-12 were determined by enzyme-linked immunosorbent assay...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26499782/clinical-effects-of-autologous-dendritic-cells-combined-with-cytokine-induced-killer-cells-followed-by-chemotherapy-in-treating-patients-with-advanced-colorectal-cancer-a-prospective-study
#20
Tao Lin, Chun Song, Dong-Yu Chuo, Hao Zhang, Jian Zhao
The objective of this study was to evaluate the effects of dendritic cell and cytokine-induced killer (DC-CIK) cell-based immunotherapy combined with chemotherapy on the treatment of patients with advanced colorectal cancer. We prospectively included patients with advanced colorectal cancer and assessed the efficacy of DC-CIK cell-based immunotherapy combined with chemotherapy compared to treatment with chemotherapy alone. T cell subtypes, progression-free survival (PFS), overall survival (OS), and adverse events were evaluated in each group...
April 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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