Douglas J Fort, Brittanie F Peake, Michael B Mathis, M Annegaaike Leopold, Jeffrey C Wolf, Peter J J M Weterings
A modified amphibian metamorphosis assay was performed in which Nieuwkoop and Faber (NF) stage 47 Xenopus laevis larvae were exposed to different concentrations of either perchlorate (ClO4 - ) or nitrate (NO3 - ) for 32 days. Larvae were exposed to 0.0 (control), 5, 25, 125, 625, and 3125 μg/L ClO4 - , or 0 (control), 23, 71, 217, 660, and 2000 mg/L NO3 - . The primary endpoints were survival, hind limb length (HLL), forelimb emergence and development, developmental stage (including time to NF stage 62 [MT62 ]), thyroid histopathology, wet weight, and snout-vent length (SVL)...
April 19, 2024: Journal of Applied Toxicology: JAT