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https://www.readbyqxmd.com/read/29786973/amniotic-fluid-lactic-acid-and-matrix-metalloproteinase-8-levels-at-the-time-of-fetal-surgery-for-a-spine-defect-association-with-subsequent-premature-preterm-rupture-of-membranes
#1
Antonio F Moron, Aikaterini Athanasiou, Mauricio Barbosa, Herbene J Milani, Stephanno G Sarmento, Sergio Cavalheiro, Steven S Witkin
OBJECTIVE: In utero fetal surgery to correct incomplete closure of the spinal cord lessens the extent of permanent damage but is associated with preterm premature rupture of membranes (pPROM). We determined if compounds in amniotic fluid (AF) collected at the time of surgery predicted subsequent development of pPROM. DESIGN: Prospective study. SETTING: Hospitals in Sao Paulo, Brazil. POPULATION: Twenty four consecutive pregnant women at 24-26 weeks gestation seen between February and October 2017 with a singleton pregnancy underwent in utero surgery to correct an open spinal defect in their fetus...
May 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29786657/eukaryotic-translation-initiation-factor-4a-down-regulation-mediates-interleukin-24-induced-apoptosis-through-inhibition-of-translation
#2
Xuelin Zhong, Leah Persaud, Hilal Muharam, Ashleigh Francis, Dibash Das, Bertal Huseyin Aktas, Moira Sauane
Dysregulated activity of helicase eIF4A drives transformation to and maintenance of cancer cell phenotype by reprogramming cellular translation. Interleukin 24 (IL-24) is a tumor-suppressing protein, which has the ability to inhibit angiogenesis, sensitize cancer cells to chemotherapy, and induce cancer cell-specific apoptosis. In this study, we found that eIF4A is inhibited by IL-24. Consequently, selective reduction of translation was observed for mRNAs harboring strong secondary structures in their 5'-untranslated regions (5'UTRs)...
May 22, 2018: Cancers
https://www.readbyqxmd.com/read/29786457/xanthine-oxidase-inhibitors-and-sepsis
#3
Maria Fátima de Paula Ramos, Alceni do Carmo Morais Monteiro de Barros, Clara Versolato Razvickas, Fernanda T Borges, Nestor Schor
Xanthine oxidase activation occurs in sepsis and results in the generation of uric acid (UrAc) and reactive oxygen species (ROS). We aimed to evaluate the effect of xanthine oxidase inhibitors (XOis) in rats stimulated with lipopolysaccharide (LPS). LPS (10 mg/kg) was administered intraperitoneally (i.p.) immediately after allopurinol (Alo, 2 mg/kg) or febuxostat (Feb, 1 mg/kg) every 24 h for 3 days. To increase UrAc levels, oxonic acid (Oxo) was administered by gavage (750 mg/kg per day) for 5 days...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29786170/immunopeptidomic-profiling-of-hla-a2-positive-triple-negative-breast-cancer-identifies-potential-immunotherapy-target-antigens
#4
Nicola Ternette, Marloes J M Olde Nordkamp, Julius Muller, Amanda P Anderson, Annalisa Nicastri, Adrian V S Hill, Benedikt M Kessler, Demin Li
The recent development in immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cells in the treatment of cancer has not only demonstrated the potency of utilising T-cell reactivity for cancer therapy, but has also highlighted the need for developing new approaches to discover targets suitable for such novel therapeutics. Here we analysed the immunopeptidomes of 6 HLA-A2-positive triple negative breast cancer (TNBC) samples by nano-ultra performance liquid chromatography tandem mass spectrometry (nUPLC-MS2 )...
May 22, 2018: Proteomics
https://www.readbyqxmd.com/read/29786071/dopamine-d2-receptor-restricts-astrocytic-nlrp3-inflammasome-activation-via-enhancing-the-interaction-of-%C3%AE-arrestin2-and-nlrp3
#5
Jialei Zhu, Zhaoli Hu, Xiaojuan Han, Dongshuo Wang, Qingling Jiang, Jianhua Ding, Ming Xiao, Cong Wang, Ming Lu, Gang Hu
Astrocytes are involved in the neuroinflammation of neurodegenerative diseases, such as Parkinson's disease (PD). Among the numerous inflammatory cytokines, interleukin-1β (IL-1β) produced by astrocytic Nod-like receptor protein (NLRP) inflammasome is crucial in the pathogenesis of PD. β-arrestin2-mediated dopamine D2 receptor (Drd2) signal transduction has been regarded as a potential anti-inflammatory target. Our previous study revealed that astrocytic Drd2 suppresses neuroinflammation in the central nervous system...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29786066/repeated-social-defeat-induced-neuroinflammation-anxiety-like-behavior-and-resistance-to-fear-extinction-were-attenuated-by-the-cannabinoid-receptor-agonist-win55-212-2
#6
Sabrina Francesca Lisboa, Anzela Niraula, Leonardo Barbosa Resstel, Francisco Silveira Guimaraes, Jonathan P Godbout, John F Sheridan
Psychosocial stress contributes to the development of psychiatric disorders. Repeated social defeat (RSD) is a murine stressor that causes a release of inflammatory monocytes into circulation. Moreover, RSD-induced anxiety-like behavior is dependent on the recruitment of these monocytes to the brain. Activation of the endocannabinoid (ECB) system may modulate both neuroendocrine and inflammatory responses mediated by stress. Therefore, we hypothesized that a cannabinoid receptor agonist would attenuate RSD-induced inflammation, anxiety, and stress sensitization...
April 17, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29785672/aberrant-t-cell-subsets-and-cytokines-expression-profile-in-systemic-lupus-erythematosus
#7
Haiyan Zhou, Bailong Hu, Niwen Huang, Xiangang Mo, Wei Li, Bei Zhang, Bo Wei, Mingzhu Gao, Yiming Wang, Xingde Liu, Joshua Liao
To assess T cell subsets and levels of chemokines and cytokines in patients with SLE and determine their relationships between disease activity and organ involvement. Blood samples from SLE patients (n = 24) and healthy controls (n = 36) were analyzed. Frequency of circulating follicular help T cells (Tfh), central memory T cells (Tcm), effector memory T cells (Tem), and naïve T cell subsets was enumerated and their surface markers expression of inducible T cell co-stimulator (ICOS) and programmed death 1(PD-1) protein was examined by flow cytometry...
May 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29785588/sam68-promotes-invasion-migration-and-proliferation-of-fibroblast-like-synoviocytes-by-enhancing-the-nf-%C3%AE%C2%BAb-p65-pathway-in-rheumatoid-arthritis
#8
Weiwei Sun, Rongqin Qin, Rui Wang, Dazhi Ding, Zhaohui Yu, Yuxi Liu, Ruilong Hong, Zhen Cheng, Youhua Wang
Src-associated substrate during mitosis of 68 KDa (Sam68), also known as KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), is the prototypic member of the signal transduction activator of RNA (STAR) family of RNA-binding proteins. Previous studies have indicated that Sam68 regulates nuclear transcription factor kappa B (NF-κB) to mediate inflammation. In this study, we analyzed the effect and possible mechanisms of Sam68 in rheumatoid arthritis (RA). By western blot analysis and immunohistochemistry, we found that the expression of Sam68 in synovial tissue of RA patients was increased compared with the control group...
May 21, 2018: Inflammation
https://www.readbyqxmd.com/read/29785459/intracorporeal-delta-shaped-gastroduodenostomy-in-reduced-port-robotic-distal-subtotal-gastrectomy-technical-aspects-and-short-term-outcomes
#9
Joong Ho Lee, Taeil Son, Jisu Kim, Won Jun Seo, Chul Kyu Rho, Minah Cho, Hyoung-Il Kim, Woo Jin Hyung
BACKGROUND: Gastroduodenostomy is preferred as a method of reconstruction following distal subtotal gastrectomy. However, in initial reports on reduced-port gastrectomy, gastroduodenostomy has rarely been performed therein because of technical difficulties. The present study describes a novel intracorporeal gastroduodenostomy technique applicable during reduced-port robotic distal subtotal gastrectomy. METHODS: Data were retrospectively reviewed for cases of reduced-port (three-port) robotic distal subtotal gastrectomy with intracorporeal delta-shaped gastroduodenostomy performed from February 2016 to December 2016...
May 21, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29785433/the-immunomodulatory-activity-and-mechanism-of-docosahexenoic-acid-dha-on-immunosuppressive-mice-models
#10
Lirong Han, Huanna Lei, Ziwei Tian, Xu Wang, Dai Cheng, Chunling Wang
In this study, the immunomodulatory activity of docosahexaenoic acid (DHA) on the immunosuppressive BALB/c mice model and its molecular mechanism are elucidated. It was found that the weight indexes of the spleen and thymus were significantly increased by DHA (44.0 mg kg-1 and 88.0 mg kg-1) treatment in the prevention or cure groups. The result of macrophages showed that DHA (44.0 mg kg-1 and 88.0 mg kg-1) could promote the proliferation and phagocytosis activity of macrophages in the prevention or cure groups...
May 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29785413/multivariate-analysis-of-inflammatory-endotypes-in-recurrent-nasal-polyposis-in-a-chinese-population
#11
B Wei, F Liu, J Zhang, Y Liu, J Du, S Liu, N Zhang, C Bachert, J Meng
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare. METHODS: 78 CRSwNP patients undergoing functional endoscopic sinus surgery were followed-up for 8 years and classified into recurrent and non-recurrent groups. A cluster analysis of the CRSwNP based on inflammatory endotypes was performed, and the endotypes were secondarily matched with clinical phenotypes...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29785404/enhanced-suppressive-activity-of-regulatory-t-cells-in-the-microenvironment-of-malignant-pleural-effusions
#12
Joanna Budna, Mariusz Kaczmarek, Agata Kolecka-Bednarczyk, Łukasz Spychalski, Piotr Zawierucha, Joanna Goździk-Spychalska, Michał Nowicki, Halina Batura-Gabryel, Jan Sikora
Cancer metastatic spread to serous cavity causes malignant pleural effusions (MPEs), indicating dismal prognosis. Tumor microenvironment can implement suppressive activity on host immune responses. Thus, we investigated the prevalence of Tregs and the relationship between them and TGF- β and IL-10 concentrations and measured expression of FOXP3 , CTLA-4 , CD28 , and GITR genes, as well as protein expression of selected genes in benign effusions and MPEs. The percentage of Tregs was determined by means of multicolor flow cytometry system...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29785192/-panax-notoginseng-promotes-repair-of-colonic-microvascular-injury-in-sprague-dawley-rats-with-experimental-colitis
#13
Shiying Wang, Ping Tao, Lei Zhao, Wangjun Zhang, Hongyi Hu, Jiang Lin
To investigate the therapeutic effects of PN on intestinal inflammation and microvascular injury and its mechanisms, dextran sodium sulfate- (DSS-) or iodoacetamide- (IA-) induced rat colitis models were used. After colitis model was established, PN was orally administered for 7 days at daily dosage of 1.0 g/kg. Obvious colonic inflammation and mucosal injuries and microvessels were observed in DSS- and IA-induced colitis groups. DAI scores, serum concentrations of VEGFA121, VEGFA165, VEGFA165/VEGFA121, IL-6, and TNF- α , and expression of Rap1GAP and TSP1 proteins in the colon were significantly higher while serum concentrations of IL-4 and IL-10 and MVD in colon were significantly lower in the colitis model groups than in the normal control group...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29785126/impact-of-targeting-transforming-growth-factor-%C3%AE-2-with-antisense-ot-101-on-the-cytokine-and-chemokine-profile-in-patients-with-advanced-pancreatic-cancer
#14
Osmond J D'Cruz, Sanjive Qazi, Larn Hwang, Kevin Ng, Vuong Trieu
Background: Overexpression of the cytokine - transforming growth factor-beta 2 (TGF-β2) - has been implicated in the malignant progression of pancreatic cancer (PAC). OT-101 (trabedersen) is an antisense oligodeoxynucleotide designed to target the human TGF-β2 mRNA. In a Phase I/II study, OT-101 treatment with subsequent chemotherapy was characterized by outstanding overall survival (OS) in patients with PAC. Objective: This study sought to identify 1) co-regulated sets of cyto-/chemokines; 2) potential mechanisms that link TGF-β receptor type 2 receptor inhibition that may result in the induction of a cytokine storm; and 3) predictive biomarkers for OS outcome in OT-101-treated patients with PAC...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785114/convenient-food-made-of-extruded-adzuki-bean-attenuates-inflammation-and-improves-glycemic-control-in-patients-with-type-2-diabetes-a-randomized-controlled-trial
#15
Yanping Liu, Qiyan Wang, Shanshan Li, Yanfen Yue, Yuling Ma, Guixing Ren
Objective: Extrusion is a widely used food processing technology. The aim of this study was to investigate the effects of extruded adzuki bean convenient food (EABCF) on glycemic and inflammation control in type 2 diabetes mellitus (T2DM) patients. Patients and methods: In a randomized controlled trial, 120 T2DM patients were randomly assigned to a control diet group (the low glycemic index [LGI] group, assigned the traditional diabetic low glycemic index diet) or an intervention group (the EABCF group, assigned daily consumption of EABCF)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29785090/semen-brassicae-ameliorates-hepatic-fibrosis-by-regulating-transforming-growth-factor-%C3%AE-1-smad-nuclear-factor-%C3%AE%C2%BAb-and-akt-signaling-pathways-in-rats
#16
Si Cao, Baoping Zheng, Tao Chen, Xinfeng Chang, Bao Yin, Zhihua Huang, Ping Shuai, Limin Han
Purpose: There is no effective treatment for liver fibrosis, which is a common phase during the progression of many chronic liver diseases to cirrhosis. Previous studies found that Semen Brassicae therapy can effectively improve the clinical symptoms of patients with asthma, allergic rhinitis, and chronic lung diseases; however, its effects on liver fibrosis in rats and its possible mechanisms of action remain unclear. Methods: Rats were injected intraperitoneally with 4% thioacetamide aqueous solution (5 mL·kg-1 ) at a dose of 200 mg·kg-1 twice a week for 8 consecutive weeks to establish the liver fibrosis model and were then treated with different concentrations of Semen Brassicae extract...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29785025/an-immune-beige-adipocyte-communication-via-nicotinic-acetylcholine-receptor-signaling
#17
Heejin Jun, Hui Yu, Jianke Gong, Juan Jiang, Xiaona Qiao, Eric Perkey, Dong-Il Kim, Margo P Emont, Alexander G Zestos, Jung-Sun Cho, Jianfeng Liu, Robert T Kennedy, Ivan Maillard, X Z Shawn Xu, Jun Wu
Beige adipocytes have recently been shown to regulate energy dissipation when activated and help organisms defend against hypothermia and obesity. Prior reports indicate that beige-like adipocytes exist in adult humans and that they may present novel opportunities to curb the global epidemic in obesity and metabolic illnesses. In an effort to identify unique features of activated beige adipocytes, we found that expression of the cholinergic receptor nicotinic alpha 2 subunit (Chrna2) was induced in subcutaneous fat during the activation of these cells and that acetylcholine-producing immune cells within this tissue regulated this signaling pathway via paracrine mechanisms...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29784900/irak-inhibitor-protects-the-intestinal-tract-of-necrotizing-enterocolitis-by-inhibiting-the-toll-like-receptor-tlr-inflammatory-signaling-pathway-in-rats
#18
Yu Hou, Xin Lu, Yueju Zhang
BACKGROUND The aim of this study was to assess the effects of interleukin-1 (IL-1) receptor associated kinase (IRAK) inhibitors on intestinal injury induced by necrotizing enterocolitis (NEC) in neonatal rats and its regulation on the intestinal Toll-like receptor (TLR) inflammatory signaling pathway. MATERIAL AND METHODS The neonatal rat models of NEC were established though hypoxia-cold stimulation. All rats were divided into 3 groups: an NEC model group (NEC group), an IRAK inhibitor group (IRAKI group), and a normal control group (NC group)...
May 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29784872/sirt1-inhibits-rheumatoid-arthritis-fibroblast-like-synoviocyte-aggressiveness-and-inflammatory-response-via-suppressing-nf-%C3%AE%C2%BAb-pathway
#19
Guoqing Li, Zhongbing Xia, Ying Liu, Fanru Meng, Xia Wu, Yuxuan Fang, Chunwang Zhang, Dan Liu
Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterized by synovial hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role in RA initiation, progression, and perpetuation. Prior studies showed that sirtuin 1(SIRT1), a deacetylase participating in a broad range of transcriptional and metabolic regulations, may impact cell proliferation and inflammatory responses. However, the role of SIRT1 in RA-FLS was unclear. Here, we explored the effects of SIRT1 on the aggressiveness and inflammatory responses of cultured RA-FLS...
May 21, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29784636/adaptive-nk-cells-resist-regulatory-t-cell-suppression-driven-by-il-37
#20
Dhifaf Sarhan, Keli L Hippen, Amanda Lemire, Skyler Hying, Xianghua Luo, Todd Lenvik, Julie Curtsinger, Zachary Davis, Bin Zhang, Sarah Cooley, Frank Cichocki, Bruce R Blazar, Jeffrey S Miller
Natural Killer (NK) cells are capable of fighting viral infections and cancer. However, these responses are inhibited by immune suppressor cells in the tumor microenvironment. Tumor progression promotes the recruitment and generation of intratumoral regulatory T cells (Tregs), associated with a poor prognosis in cancer patients. Here, we show that canonical NK cells are highly susceptible to Treg-mediated suppression, in contrast to highly resistant CD57+ FcεRγ-NKG2C+ adaptive (CD56+CD3-) NK cells that expand in cytomegalovirus (CMV)-exposed individuals...
May 21, 2018: Cancer Immunology Research
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