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Arterial switch

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https://www.readbyqxmd.com/read/29777903/sox9-is-increased-in-arterial-plaque-and-stenosis-associated-with-synthetic-phenotype-of-vascular-smooth-muscle-cells-and-causes-alterations-in-extracellular-matrix-and-calcification
#1
Antje Augstein, Johannes Mierke, David M Poitz, Ruth H Strasser
Vascular smooth muscle cells (VSMC) exhibit a dual role in progression and maintenance of arteriosclerosis. They are fundamental for plaque stability but also can drive plaque progression. During pathogenic vascular remodeling, VSMC transdifferentiate into a phenotype with enhanced proliferation and migration. Moreover, they exert an increased capacity to generate extracellular matrix proteins. A special lineage of transdifferentiated VSMC expresses Sox9, a multi-functional transcription factor. The aim of the study was to examine the role of Sox9 in phenotypic alterations leading to arteriosclerosis...
May 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29766812/switching-dipeptidyl-peptidase-4-inhibitors-to-tofogliflozin-a-selective-inhibitor-of-sodium-glucose-cotransporter-2-improves-arterial-stiffness-evaluated-by-cardio-ankle-vascular-index-in-patients-with-type-2-diabetes
#2
Nobuhiro Tahara, Sho-Ichi Yamagish, Munehisa Bekki, Atsuko Tahara, Sachiyo Igata, Akihiro Honda, Yoichi Sugiyama, Tomohisa Nakamura, Jiahui Sun, Yuki Kumashiro, Takanori Matsui, Yoshihiro Fukumoto
BACKGROUND: We have found that anagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4) significantly ameliorates arterial stiffness in type 2 diabetes mellitus (T2DM) patients compared with an equivalent hypoglycemic agent, glimepiride. However, it remains unclear whether and how switching DPP-4 inhibitors to tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2) improves arterial stiffness in T2DM patients. METHODS: Nineteen T2DM patients who had received DPP-4 inhibitors for at least 1 year were enrolled in this study...
May 15, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29762057/comparison-of-image-quality-and-radiation-exposure-between-conventional-imaging-and-gemstone-spectral-imaging-in-abdominal-ct-examination
#3
Tianqi Fang, Wei Deng, Martin Wai-Ming Law, Liangping Luo, Liyun Zheng, Ying Guo, Hanwei Chen, Bingsheng Huang
OBJECTIVE: To compare patients' image quality and radiation exposure between gemstone spectral imaging (GSI) with rapid kV switching technique and conventional polychromatic imaging performed in abdominal CT examinations. METHODS: Adult patients who were referred to abdominal CT from October 2015 to March 2016 were enrolled. Unenhanced CT with conventional polychromatic imaging mode and tri-phase (arterial/portal/delayed phase) contrast-enhanced scan with GSI mode were performed with different protocols respectively...
May 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29761842/design-and-performance-evaluation-of-real-time-endovascular-interventional-surgical-robotic-system-with-high-accuracy
#4
Kundong Wang, Bing Chen, Qingsheng Lu, Hongbing Li, Manhua Liu, Yu Shen, Zhuoyan Xu
BACKGROUND: Endovascular interventional surgery (EIS) is performed under a high radiation environment at the sacrifice of surgeons' health. This paper introduces a novel endovascular interventional surgical robot that aims to reduce radiation to surgeons and physical stress imposed by lead aprons during fluoroscopic X-ray guided catheter intervention. METHODS: The unique mechanical structure allowed the surgeon to manipulate the axial and radial motion of the catheter and guide wire...
May 15, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29757431/long-term-quality-of-life-in-adult-survivors-after-the-arterial-switch-operation
#5
Tyson A Fricke, Benjamin R Loyer, Li Huang, Sophie Griffiths, Nima Yaftian, Kim M Dalziel, Johann Brink, Yves d'Udekem, Christian P Brizard, Igor E Konstantinov
OBJECTIVES: We sought to determine the quality of life after the arterial switch operation (ASO) using the Short Form 36 questionnaire in adult survivors. METHODS: All patients (n = 107) who underwent the ASO and were 18 years of age or older living in the Australian state of Victoria with a contact telephone number were identified from the hospital database. Fifty-one (48%) patients were 18-24 years old and 56 (52%) patients were 25-34 years old. Patients completed the Short Form 36 quality of life questionnaire via telephone...
May 10, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29748700/myocardial-stress-perfusion-mri-experience-in-pediatric-and-young-adult-patients-following-arterial-switch-operation-utilizing-regadenoson
#6
Cory V Noel, Ramkumar Krishnamurthy, Prakash Masand, Brady Moffett, Tobiash Schlingmann, Benjamin Y Cheong, Rajesh Krishnamurthy
Dextro-transposition of the great arteries (D-TGA) is one of the most common cyanotic heart lesions. The arterial switch operation (ASO) is the preferred surgical palliation for D-TGA. One of the primary concerns following the ASO is complications arising from the coronary artery transfer. There is a need for myocardial perfusion assessment within ASO patients. There is no report on the utility of regadenoson as a stress agent in children following ASO. Our objective was to observe the safety and feasibility of regadenoson as a pharmacologic stressor for perfusion cardiac MR in a pilot cohort of pediatric and young-adult patients who have undergone ASO...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29715702/incidence-and-risk-factors-for-right-ventricular-outflow-tract-obstruction-after-the-arterial-switch-operation
#7
Julie Cleuziou, Keti Vitanova, Jelena Pabst von Ohain, Masamichi Ono, Daniel Tanase, Melchior Burri, Rüdiger Lange
BACKGROUND:  The aim of this study was to evaluate the incidence and risk factors for the development of right ventricular outflow tract obstruction (RVOTO) after the arterial switch operation (ASO). METHODS:  Between 1983 and 2014, a total of 688 patients underwent ASO. RVOTO was defined as any obstruction of the right ventricular outflow tract (RVOT) requiring reintervention. RESULTS:  RVOTO developed in 79 patients (11%) at a median time of 3...
May 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29701356/arterial-switch-how-to-predict-reoperation
#8
Carolina Rodrigues, Rui Cerejo
INTRODUCTION: Jatene surgery or arterial switch is performed at our institution since 1989. It is mandatory to submit our results to an evaluation that allow us to identify the main causes of reoperation and, more importantly, to determine what variables predict the need of reoperation. METHODS: In this retrospective analysis were included all the 91 patients with d-TGA who underwent an arterial switch operation at Santa Marta Hospital between 1999 and 2016. RESULTS: Mean follow-up was 6 years (range 1-21 years)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700702/the-impact-of-serum-uric-acid-reduction-on-renal-function-and-blood-pressure-in-chronic-kidney-disease-patients-with-hyperuricemia
#9
Takayuki Tsuji, Kazuhisa Ohishi, Asumi Takeda, Daiki Goto, Taichi Sato, Naro Ohashi, Yoshihide Fujigaki, Akihiko Kato, Hideo Yasuda
BACKGROUND: Febuxostat is tolerable in chronic kidney disease (CKD) patients with hyperuricemia. However, the long-term effect of lowering uric acid with febuxostat on renal function and blood pressure has not been elucidated. METHODS: This was a 2 years retrospective observational study. 86 CKD patients with hyperuricemia who continued with allopurinol (allopurinol group, n = 30), switched from allopurinol to febuxostat (switched group, n = 25), or were newly prescribed febuxostat (febuxostat group, n = 31) were included in this study...
April 26, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29698662/liberal-use-of-delayed-sternal-closure-in-children-is-not-associated-with-increased-morbidity
#10
S Ram Kumar, Nigel Scott, Winfield J Wells, Vaughn A Starnes
BACKGROUND: Delayed sternal closure (DSC) is often employed to optimize hemodynamics following pediatric cardiac surgery. Prior reports have suggested that DSC may be associated with increased morbidity. We sought to analyze the impact of a liberal policy of DSC on surgical outcomes at our center. METHODS: We retrospectively evaluated the clinical course of 1,000 consecutive patients between July 2005 and June 2015 whose sternum was electively left open following pediatric cardiac surgery...
April 23, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29697021/successful-late-recruitment-of-the-occluded-left-main-coronary-artery-after-initial-arterial-switch-operation
#11
Krzysztof W Michalak, Maciej Moll, Tomasz Moszura, Jacek Jan Moll
We describe a surgical technique for late recruitment of the proximally occluded left main coronary artery (LMCA) after initial arterial switch operation, which had been complicated by severe left ventricular dysfunction. This technique allowed for LMCA recanalization, using the patent conal artery branching off the LMCA close to the ostium. It is particularly useful in small children, where surgical options for coronary arteries are limited and associated with a high risk of restenosis. It was successfully used in a two-month-old boy with successful revascularization confirmed by angiography...
May 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29686017/neurotransmitter-switching-coupled-to-%C3%AE-adrenergic-signaling-in-sympathetic-neurons-in-prehypertensive-states
#12
Emma N Bardsley, Harvey Davis, Keith J Buckler, David J Paterson
Single or combinatorial administration of β-blockers is a mainstay treatment strategy for conditions caused by sympathetic overactivity. Conventional wisdom suggests that the main beneficial effect of β-blockers includes resensitization and restoration of β1-adrenergic signaling pathways in the myocardium, improvements in cardiomyocyte contractility, and reversal of ventricular sensitization. However, emerging evidence indicates that another beneficial effect of β-blockers in disease may reside in sympathetic neurons...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29685522/rapid-switching-kvp-dual-energy-ct-value-of-reconstructed-dual-energy-ct-images-and-organ-dose-assessment-in-multiphasic-liver-ct-exams
#13
Usman Mahmood, Natally Horvat, Joao Vicente Horvat, Davinia Ryan, Yiming Gao, Gabriella Carollo, Rommel DeOcampo, Richard K Do, Seth Katz, Scott Gerst, C Ross Schmidtlein, Lawrence Dauer, Yusuf Erdi, Lorenzo Mannelli
PURPOSE: Clinical applications of dual energy computed tomography (DECT) have been widely reported; however, the importance of the different image reconstructions and radiation organ dose remains a relevant area of investigation, particularly considering the different commercially available DECT equipment. Therefore, the purpose of this study was to assess the image reliability and compare the information content between several image reconstructions in a rapid-switching DECT (rsDECT), and assess radiation organ dose between rsDECT and conventional single-energy computed tomography (SECT) exams...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29685148/recurrent-inhibition-of-mitochondrial-complex-iii-induces-chronic-pulmonary-vasoconstriction-and-glycolytic-switch-in-the-rat-lung
#14
Olga Rafikova, Anup Srivastava, Ankit A Desai, Ruslan Rafikov, Stevan P Tofovic
BACKGROUND: Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we investigated the effects of chronic inhibition of mitochondrial function in vivo in healthy rodents. METHODS: Right ventricle systolic pressure (RVSP) was measured in female rats at baseline and up to 24 days after inhibition of mitochondrial respiratory Complex III, induced by Antimycin A (AA, 0...
April 23, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#15
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29673637/arterial-switch-ventricular-septation-and-fontan-takedown-for-double-inlet-left-ventricle
#16
Shu-Chien Huang, Shyh-Jye Chen, Yi-Chia Wang, Chi-Hsiang Huang, Shuenn-Nan Chiu, Yih-Sharng Chen
A patient with double inlet left ventricle with transposition of great arteries, and severe coarctation of the aorta received aortoplasty and pulmonary artery banding, followed by bidirectional Glenn shunt and extracardiac total cavopulmonary connection(TCPC). Severe subaortic stenosis and increased atrio-ventricular valve regurgitation were noted 4 years after TCPC.
April 16, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29671011/-rectal-bleeding-in-a-60-year-old-woman-under-anticoagulation-and-platelet-aggregation-inhibition
#17
J Pohlan, N Willamowski, C Jürgensen, E Zimmermann, M Möckel
CASE REPORT: We report on a woman with lower gastrointestinal bleeding under effective oral anticoagulation with both phenprocoumon and apixaban (with intention to switch to the latter) as well as the antiplatelet agent acetylsalicylic acid for aortic bifurcation kissing stents after stent thrombosis. Our patient presented with weakness and rectal bleeding. Upon examination, she looked anemic and had sinus tachycardia (104 beats per minute). The digital rectal examination revealed bright red blood mixed with clots...
April 18, 2018: Der Internist
https://www.readbyqxmd.com/read/29657908/a-rare-case-of-coronary-artery-embolism-in-a-patient-with-d-transposition-of-the-great-arteries-with-prior-mustard-repair
#18
Prince Sethi, Udit Bhatnagar, Kelly Steffen, Edgard Bendaly, Adam Stys
The dextro-transposition of great arteries (d-TGA) is a rare, congenital, cyanotic heart disease and there is a paucity of data regarding long-term cardiovascular outcomes. We present a rare case of non-ST-elevation myocardial infarction (NSTEMI) in a patient with surgically repaired d-TGA. A 43-year-old male who had previously undergone a Mustard atrial switch palliative procedure presented with chest pain and diaphoresis and was diagnosed with NSTEMI. A coronary angiogram revealed a small, underdeveloped, left anterior descending and a large, left circumflex coronary artery with an acute embolic lesion...
February 12, 2018: Curēus
https://www.readbyqxmd.com/read/29657375/comparison-of-glycemic-control-between-continuous-regular-insulin-infusion-and-single-dose-subcutaneous-insulin-glargine-injection-in-medical-critically-ill-patients
#19
Rungsun Bhurayanontachai, Tharittamon Rattanaprapat, Chanon Kongkamol
Background and Aims: This study aimed to compare glycemic control between continuous intravenous regular insulin infusion and single-dose subcutaneous insulin glargine injection in medical critically ill patients. Subjects and Methods: A prospective noninferiority study was conducted in medical critically ill patients who developed hyperglycemia and required regular insulin infusion by the Intensive Care Unit glycemic control protocol. The eligible patients were switched from the daily regular insulin requirement to single-dose subcutaneous insulin glargine injection by a 100% conversion dose...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29652636/hif1-mediates-a-switch-in-pyruvate-kinase-isoforms-after-myocardial-infarction
#20
Allison Lesher Williams, Vedbar Khadka, Mingxin Tang, Abigail Avelar, Kathryn J Schunke, Mark Menor, Ralph Victor Shohet
Alternative splicing of RNA is an underexplored area of transcriptional response. We expect that early changes in alternatively spliced genes may be important for responses to cardiac injury. Hypoxia inducible factor 1 (HIF1) is a key transcription factor that rapidly responds to loss of oxygen through alteration of metabolism and angiogenesis. The goal of this study was to investigate the transcriptional response after myocardial infarction (MI) and to identify novel, hypoxia-driven changes, including alternative splicing...
April 13, 2018: Physiological Genomics
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