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Juvenile idiopatic arthritis

Federica Raggi, Simone Pelassa, Daniele Pierobon, Federica Penco, Marco Gattorno, Francesco Novelli, Alessandra Eva, Luigi Varesio, Mirella Giovarelli, Maria Carla Bosco
Macrophages (Mf) are a heterogeneous population of tissue-resident professional phagocytes and a major component of the leukocyte infiltrate at sites of inflammation, infection, and tumor growth. They can undergo diverse forms of activation in response to environmental factors, polarizing into specialized functional subsets. A common hallmark of the pathologic environment is represented by hypoxia. The impact of hypoxia on human Mf polarization has not been fully established. The objective of this study was to elucidate the effects of a hypoxic environment reflecting that occurring in vivo in diseased tissues on the ability of human Mf to polarize into classically activated (proinflammatory M1) and alternatively activated (anti-inflammatory M2) subsets...
2017: Frontiers in Immunology
Luciane Macedo de Menezes, Susana Maria Deon Rizzatto, Eduardo Martinelli Santayana de Lima, Paulo Ricardo Baccarin Matje, Maria Mercedes Picarelli
Juvenile idiopathic arthritis is a childhood disease that causes joint swelling and pain, and limitation in the range of joint movements. It is characterized by progressive destruction of the joints. Juvenile idiopathic arthritis is the most frequent systemic inflammatory disease of the temporomandibular joint. When the temporomandibular joint is involved, orthodontic treatment becomes more challenging. This case report shows the treatment of a young patient with a Class II subdivision malocclusion and juvenile idiopathic arthritis...
February 2017: American Journal of Orthodontics and Dentofacial Orthopedics
Cinzia Maspero, Lucia Giannini, Guido Galbiati, Chiara Prevedello, Giampietro Farronato
BACKGROUND: The possible relationship between periodontitis and juvenile idiopathic arthritis (JIA) is now mostly unknown but there are common characteristics in these two diseases. The purpose of this study is to evaluate etanercept (Enbrel®) effects on periodontal conditions of children affected by JIA. METHODS: For this study three group of patients were selected. The first one is represented by JIA subjects in pharmacologic therapy with etanercept (Enbrel®)...
April 2017: Minerva Stomatologica
Giancarla Dilandro, Valentina De Cosmi, Fabrizia Corona, Marta Torcoletti, Antonella Petaccia, Giovanni Filocamo, Andrea Budelli, Carlo Agostoni
Within an observational open study on the effects of a scheduled dosage of biscuits with iron, children with juvenile idiopathic arthritis were either supplemented with biscuits supplying iron fumarate (median 3.6 mg per day) or left to their customary dietary habits. After 4 months, supplemented children showed a more favourable percentage change of blood haemoglobin, while ferritin levels (markers of inflammation) remained stable. We conclude that the supply of iron with available dietary products may contribute to an adequate iron status in children with chronic inflammatory disorders in a stable situation...
2015: International Journal of Food Sciences and Nutrition
C Pham, V Utz, A Marcotty, A Zeft, P Rychwalski
We report two patients who presented with Brown's syndrome. The first is a 7-year-old boy who at the time of his diagnosis was also found to have enthesitis and HLA-B27 positivity. The second patient was diagnosed with bilateral Brown's syndrome at 13 months of age. At age 7 she developed a persistent oligoarticular arthritis and unilateral anterior iritis consistent with the oligoarticular Juvenile Idiopatic Arthritis (JIA) phenotype. These cases highlight ophthalmologic findings and diagnostic considerations with respect to Brown's syndrome and associated childhood onset rheumatologic disease...
November 6, 2014: Reumatismo
M Portelli, G Matarese, A Militi, G Logiudice, R Nucera, A Lucchese
AIM: The aim of the study was to assess possible correlations between the clinical parameters of temporomandibular joint (TMJ) arthritis and pathologic MRI findings of the TMJ in patients affected by juvenile idiopathic arthritis (JIA), and the effect of a functional orthodontic therapy on the evolution of TMJ disorders. MATERIALS AND METHODS: A prospective clinical and nuclear magnetic resonance (NMR) investigation was conducted on a sample of 53 patients (41 female, 12 male) with JIA, treated for 24 months with an Andresen appliance...
March 2014: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
V Amialyanchyk, A Giovagnoni, E Filippucci, E Dimitri, S Angeloni, G D'Angelo
The juvenile idiopatic arthritis (JIA) is the childhood most common rheumatologic disorder. The JIA diagnosis is not based on specific clinical and serological markers, but mainly on the ultrasound and magnetic resonance imaging investigations. The use of both these imaging techniques seem to be very promising, especially for the ultrasound. In fact, the improvement in both the ultrasound methods (power e colour Doppler, high resolution technique) and the operator knowledge could give the same results of the MRI imaging leading to a better cost-benefit ratio...
September 2011: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
I Rybar, E Rozborilova, E Zanova, D Micekova, I Solovic, J Rovensky
BACKGROUND: New biologic therapies blocking TNF undoubtly constitute a considerable advancement in the management mentioned diseases, but are also associated with higher risk of activation of tuberculosis. METHODS: An assessment of tuberculosis activation rate in the group of patients with rheumatoid arthritis, juvenile idiopatic arthritis, ankylosing spondylitis and psoriatic arthritis threated by anti-TNF inhibitors since January 1st 2001 to June 30th 2007 in Slovakia and went in for special anti-tuberculosis screening before start of therapy...
2008: Bratislavské Lekárske Listy
Ewa Lipiec, Mirosława Grałek, Anna Niwald
PURPOSE: The aim of the study was to evaluate the dry eye syndrome in children with juvenile idiopathic arthritis (JIA), and its relation to the immunological markers of the JIA (antynuclear antybodies ANA and rheumatoid factor RF). MATERIAL AND METHODS: The study included 62 children with JIA. The age of patients during the first ophthalmic examination ranged from 9 to 18 years (62 children). A control group consisted of 49 healthy children. The time of observation was 18 months during which the children and adolescents were subjected to complex ophthalmic examinations (including a history of eye discomfort and Schirmer and BUT tests), in the intervals of 9 months...
2008: Klinika Oczna
Piotr Muszyński, Jacek Składzień, E Reroń, P Strek, L Popielski, M Dutsch-Wicherel, S Kocoń, J Bartnik
Juvenile idiopathic arthritis (JCA) is an inflammatory systemic disease of connective tissue which etiology is still unknown. Progressive arthritis is the basic symptom, with pain, oedema, stiffness and movement impediment are typical for. Chronic process of arthritis might be accompanied by rheumatoid nodes, pericarditis, myocarditis, changes in the lungs and kidney, which appear with various frequency and indicates on systemic form of disease. The incudo-malleolar and incudo-stapedial joints are synovial in type...
2007: Otolaryngologia Polska
Hans Callø Fledelius, Susan M Nielsen, Kamilla Rothe Nissen, Freddy Karup Pedersen, Marek Stanislaw Zak
INTRODUCTION: To present our experience with anti-TNFalpha treatment of juvenile idiopatic arthritis (JIA) associated uveitis. MATERIALS AND METHODS: All 11 children with severe uveitis were monitored between 2001 and 2005. Nine of the children had JIA and a set of twins had a rare hereditary granulomatous disease, Blau's syndrome. The patients were selected and the reason for starting anti-TNFalpha treatment was an insufficient response in the arthritis or uveitis to previous therapy...
April 2, 2007: Ugeskrift for Laeger
Dalia Baksiene, Jūrate Kasparaviciene, Migla Zebiene, Brigita Puteliene
UNLABELLED: THE PURPOSE OF THE STUDY was to evaluate the peculiarities of the clinical features, laboratory parameters and tactics of treatment in juvenile idiopatic systematic arthritis. METHODS: A retrospective data review of 41 children (26 boys and 15 girls) who underwent treatment for systemic arthritis (according to ILAR criteria) in our institution between 1992 and 2002 was performed. RESULTS: The disease started with fever of unknown origin in all cases...
2003: Medicina
Jacek Postepski, Violetta Opoka-Winiarska, Maria Kozioł-Montewka, Agnieszka Korobowicz, Ewa Tuszkiewicz-Misztal
UNLABELLED: Although more and more is known about chronic autoimmune diseases, attempts to establish one trigger factor have been unsuccessful. The role of endogenic factors is beyond doubt. But it is emphasized that environmental factors are necessary to cause the disease. Infections are taken under consideration as trigger mechanism in the development of autoimmune diseases including chronic arthritis. Both numerous viruses and bacteria are among the microorganism mentioned. We considered it sensible to conduct research on Mycoplasma pneumoniae infections in a group of patients with juvenile idiopathic arthritis (JIA)...
April 2003: Medycyna Wieku Rozwojowego
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