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https://www.readbyqxmd.com/read/29693586/ellagic-acid-alleviates-hepatic-oxidative-stress-and-insulin-resistance-in-diabetic-female-rats
#1
Simran Alexandria Polce, Cameron Burke, Lucas Martins França, Benjamin Kramer, Antonio Marcus de Andrade Paes, Maria Alicia Carrillo-Sepulveda
Non-alcoholic fatty liver disease (NAFLD) affects more than 70% of patients with type 2 diabetes mellitus (T2DM) and has become one of the most common metabolic liver diseases worldwide. To date, treatments specifically targeting NAFLD do not exist. Oxidative stress and insulin resistance have been implicated in the pathogenesis of NAFLD in diabetes. Accordingly, the goal of this present study was to determine whether Ellagic acid (EA), a natural antioxidant polyphenol found in berries and nuts, mitigates hepatic oxidative stress and insulin resistance in T2DM rats, and thus alleviates NAFLD...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29678861/the-tomato-mitogen-activated-protein-kinase-slmpk1-is-as-a-negative-regulator-of-the-high-temperature-stress-response
#2
Haidong Ding, Jie He, Yuan Wu, Xiao-Xia Wu, Cailin Ge, Yijun Wang, Silin Zhong, Edgar Peiter, Jian-Sheng Liang, Weifeng Xu
High temperature (HT) stress is a major environmental stress that limits plant growth and development. Mitogen-activated protein kinase (MAPK) cascades play key roles in plant growth and stress signaling, but their involvement in the HT stress response are poorly understood. Here, we describe a 47-kDa MBP-phosphorylated protein (p47-MBPK) activated in tomato (Solanum lycopersicum) leaves under HT, and identify it as SlMPK1 by MS/MS analysis. Silencing of SlMPK1 in transgenic tomato plants resulted in enhanced tolerance to HT, while overexpression resulted in reduced tolerance...
April 20, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29660503/high-circulatory-leptin-mediated-nox-2-peroxynitrite-mir21-axis-activate-mesangial-cells-and-promotes-renal-inflammatory-pathology-in-nonalcoholic-fatty-liver-disease
#3
Firas Alhasson, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A Kimono, Muayad S Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, Geoffrey I Scott, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin in NAFLD is associated with renal disease severity. Extending the studies, we hypothesized that high circulatory leptin in NAFLD causes renal mesangial cell activation and tubular inflammation via a NOX2 dependent pathway that upregulates proinflammatory miR21...
April 7, 2018: Redox Biology
https://www.readbyqxmd.com/read/29660332/dusp14-knockout-accelerates-cardiac-ischemia-reperfusion-ir-injury-through-activating-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways-modulated-by-ros-generation
#4
Bin Lin, Jing Xu, De-Guang Feng, Feng Wang, Jia-Xiang Wang, Hui Zhao
Inflammation and oxidative stress are significantly involved in the progression of a variety of diseases, including myocardial ischemia/reperfusion (IR). In the present study, we hypothesized a protective role of dual-specificity phosphatase 14 (DUSP14) in myocardial IR, as well as the underlying molecular mechanism. The results indicated that DUSP14 was down-regulated following cardiac IR injury. Subsequently, the wild type (WT) and DUSP14-knockout (KO) mice were included to further reveal the potential role of DUSP14 in cardiac IR injury progression...
May 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29599289/interaction-between-the-aaa-atpase-p97-vcp-and-a-concealed-ubx-domain-in-the-copper-transporter-atp7a-is-associated-with-motor-neuron-degeneration
#5
Ling Yi, Stephen G Kaler
The copper-transporting ATPase ATP7A contains eight transmembrane domains and is required for normal human copper homeostasis. Mutations in the ATP7A gene may lead to infantile-onset cerebral degeneration (Menkes disease); occipital horn syndrome (OHS), a related but much milder illness; or an adult-onset isolated distal motor neuropathy. The ATP7A missense mutation T994I is located in the sixth transmembrane domain of ATP7A, represents one of the variants associated with the latter phenotype, and is associated with an abnormal interaction with p97/valosin-containing protein (VCP), a hexameric AAA ATPase (ATPase associated with diverse cellular activities) with multiple biological functions...
March 29, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29567995/molecular-camouflage-of-plasmodium-falciparum-merozoites-by-binding-of-host-vitronectin-to-p47-fragment-of-sera5
#6
Takahiro Tougan, Jyotheeswara R Edula, Eizo Takashima, Masayuki Morita, Miki Shinohara, Akira Shinohara, Takafumi Tsuboi, Toshihiro Horii
The malaria parasite Plasmodium falciparum proliferates in the blood stream where the host immune system is most active. To escape from host immunity, P. falciparum has developed a number of evasion mechanisms. Serine repeat antigen 5 (SERA5) is a blood stage antigen highly expressed at late trophozoite and schizont stages. The P47 N-terminal domain of SERA5, the basis of SE36 antigen of the blood stage vaccine candidate under clinical trials, covers the merozoite surface. Exploring the role of the P47 domain, screening of serum proteins showed that vitronectin (VTN) directly binds to 20 residues in the C-terminal region of SE36...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29552626/neutrophil-hepatic-stellate-cell-interactions-promote-fibrosis-in-experimental-steatohepatitis
#7
Zhou Zhou, Ming-Jiang Xu, Yan Cai, Wei Wang, Joy X Jiang, Zoltan V Varga, Dechun Feng, Pal Pacher, George Kunos, Natalie J Torok, Bin Gao
Background & Aims: Hepatic infiltration of neutrophils is a hallmark of steatohepatitis; however, the role of neutrophils in the progression of steatohepatitis remains unknown. Methods: A clinically relevant mouse model of steatohepatitis induced by high-fat diet (HFD) plus binge ethanol feeding was used. Liver fibrosis was examined. In vitro cell culture was used to analyze the interaction of hepatic stellate cells (HSCs) and neutrophils. Results: HFD plus one binge ethanol (HFD+1B) feeding induced significant hepatic neutrophil infiltration, liver injury, and fibrosis...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29544378/glucose-and-lipid-metabolism-alterations-in-liver-and-adipose-tissue-pre-dispose-p47-phox-knockout-mice-to-systemic-insulin-resistance
#8
Babu Nageswararao Kanuri, Sanjay C Rebello, Priya Pathak, Hobby Agarwal, Jitendra S Kanshana, Deepika Awasthi, Anand P Gupta, Jiaur R Gayen, Kumaravelu Jagavelu, Madhu Dikshit
Oxidative stress due to enhanced production or reduced scavenging of reactive oxygen species (ROS) has been associated with diet (dyslipidemia) induced obesity and insulin resistance (IR). The present study was undertaken to assess the role of p47phox in IR using wild type (WT) and p47phox-/- mice, fed with different diets (HFD, LFD or Chow). Augmented body weight, glucose intolerance and reduced insulin sensitivity were observed in p47phox-/- mice fed with 45% HFD and 10% LFD. Further, body fat and circulating lipids were increased significantly with 5 weeks LFD feeding in p47phox-/- mice, while parameters of energy homeostasis were reduced as compared with WT mice...
April 3, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29516629/genomic-sequences-of-hla-a-68-169-hla-b-07-298-and-hla-b-39-129
#9
A Balas, D Planelles, M Rodríguez-Cebriá, N Puig, J L Vicario
Three new HLA class I alleles were described in the Spanish population. HLA-A*68:169 and -B*39:129 show one amino acid replacement at the α1-domain, compared to A*68:02 (P47 > L47) and -B*39:06 (S11 > A11), respectively. HLA-B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position -14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA-B genes...
March 8, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29296942/gene-edited-pseudogene-resurrection-corrects-p47-phox-deficient-chronic-granulomatous-disease
#10
Randall K Merling, Douglas B Kuhns, Colin L Sweeney, Xiaolin Wu, Sandra Burkett, Jessica Chu, Janet Lee, Sherry Koontz, Giovanni Di Pasquale, Sandra A Afione, John A Chiorini, Elizabeth M Kang, Uimook Choi, Suk See De Ravin, Harry L Malech
Pseudogenes are duplicated genes with mutations rendering them nonfunctional. For single-gene disorders with homologous pseudogenes, the pseudogene might be a target for genetic correction. Autosomal-recessive p47phox -deficient chronic granulomatous disease (p47-CGD) is a life-threatening immune deficiency caused by mutations in NCF1 , a gene with 2 pseudogenes, NCF1B and NCF1C . The most common NCF1 mutation, a GT deletion (ΔGT) at the start of exon 2 (>90% of alleles), is constitutive to NCF1B and NCF1C ...
January 10, 2017: Blood Advances
https://www.readbyqxmd.com/read/29229188/plasmodium-p47-a-key-gene-for-malaria-transmission-by-mosquito-vectors
#11
REVIEW
Alvaro Molina-Cruz, Gaspar E Canepa, Carolina Barillas-Mury
Malaria is caused by infection with Plasmodium parasites that have a complex life cycle. The parasite protein P47 is critical for disease transmission. P47 mediates mosquito immune evasion in both Plasmodium berghei (Pbs47) and Plasmodium falciparum (Pfs47), and has been shown to be important for optimal female gamete fertility in P. berghei. Pfs47 presents strong geographic structure in natural P. falciparum populations, consistent with natural selection of Pfs47 haplotypes by the mosquito immune system as the parasite adapted to new vector species worldwide...
December 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29192236/estrogen-attenuates-agtr1-expression-to-reduce-pancreatic-%C3%AE-cell-death-from-high-glucose
#12
Suwattanee Kooptiwut, Keerati Wanchai, Namoiy Semprasert, Chatchawan Srisawat, Pa-Thai Yenchitsomanus
Chronic exposure of pancreatic β-cells to high glucose levels results in β-cell dysfunction and death. These effects can be protected by estrogen. The local pancreatic renin-angiotensin system (RAS) has been shown as a novel pathological pathway of high-glucose-induced cell death. The effect of estrogen on pancreatic RAS is still unknown. This study examines whether estrogen protects against pancreatic β-cell death caused by glucotoxicity via a decrease in the pancreatic β-cell RAS pathway. When INS-1 cells were cultured in a high glucose medium, cell death was significantly higher than when the cells were cultured in a basal glucose medium; similarly, there were also higher levels of AGTR1 and p47ph °x mRNA, and protein expression...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29183727/resveratrol-strongly-enhances-the-retinoic-acid-induced-superoxide-generating-activity-via-up-regulation-of-gp91-phox-gene-expression-in-u937-cells
#13
Hidehiko Kikuchi, Hitomi Mimuro, Futoshi Kuribayashi
The membrane bound cytochrome b558 composed of gp91-phox and p22-phox proteins, and cytosolic proteins p40-, p47-and p67-phox are important components of superoxide (O2 - )-generating system in phagocytes. Here, we describe that resveratrol, a pleiotropic phytochemical belonging to the stilbenoids, dramatically activates the O2 - -generating system during retinoic acid (RA)-induced differentiation of human monoblastic leukemia U937 cells to macrophage-like cells. When U937 cells were cultured in the presence of RA and resveratrol, the O2 - -generating activity increased more than 5-fold compared with that in the absence of the latter...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29154191/integrin-cd11b-mediates-%C3%AE-synuclein-induced-activation-of-nadph-oxidase-through-a-rho-dependent-pathway
#14
Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang
The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play important roles in α-synuclein-induced microglial activation. In this study, we found that blocking CD11b, the α chain of integrin αM β2 , but not TLR2 attenuated α-synuclein-induced NOX2 activation in microglia. The involvement of CD11b in α-synuclein-induced activation of NOX2 was further confirmed in CD11b-/- microglia by showing reduced membrane translocation of NOX2 cytosolic subunit p47phox and superoxide production...
April 2018: Redox Biology
https://www.readbyqxmd.com/read/29135572/long-term-observational-studies-of-chronic-granulomatous-disease
#15
Maria Kanariou, Kleopatra Spanou, Sofia Tantou
PURPOSE OF REVIEW: Chronic granulomatous disease (CGD) is a primary immunodeficiency, with a defect of phagocytes in killing specific pathogens. CGD is characterized by severe recurrent bacterial and fungal infections and dysregulated inflammatory response. Since its first description as fatal disease about 60 years ago, a significant improvement in outcome has been achieved in the last 20 years. The purpose of this review is to framework recent advances in CGD immunopathogenesis, management of disease manifestation and cure of CGD patients...
January 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29081748/coq10-augments-rosuvastatin-neuroprotective-effect-in-a-model-of-global-ischemia-via-inhibition-of-nf-%C3%AE%C2%BAb-jnk3-bax-and-activation-of-akt-foxo3a-bim-cues
#16
Sarah A Abd El-Aal, Mai A Abd El-Fattah, Hanan S El-Abhar
Statins were reported to lower the Coenzyme Q10 (CoQ10) content upon their inhibition of HMG-CoA reductase enzyme and both are known to possess neuroprotective potentials; therefore, the aim is to assess the possible use of CoQ10 as an adds-on therapy to rosuvastatin to improve its effect using global I/R model. Rats were allocated into sham, I/R, rosuvastatin (10 mg/kg), CoQ10 (10 mg/kg) and their combination. Drugs were administered orally for 7 days before I/R. Pretreatment with rosuvastatin and/or CoQ10 inhibited the hippocampal content of malondialdehyde, nitric oxide, and boosted glutathione and superoxide dismutase...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29079525/conversion-of-nox2-into-a-constitutive-enzyme-in-vitro-and-in-living-cells-after-its-binding-with-a-chimera-of-the-regulatory-subunits
#17
Rawand Masoud, Xavier Serfaty, Marie Erard, Paul Machillot, Gilda Karimi, Elodie Hudik, Frank Wien, Laura Baciou, Chantal Houée-Levin, Tania Bizouarn
During the phagocytosis of pathogens by phagocyte cells, the NADPH oxidase complex is activated to produce superoxide anion, a precursor of microbial oxidants. The activated NADPH oxidase complex from phagocytes consists in two transmembrane proteins (Nox2 and p22(phox)) and four cytosolic proteins (p40(phox), p47(phox), p67(phox) and Rac1-2). In the resting state of the cells, these proteins are dispersed in the cytosol, the membrane of granules and the plasma membrane. In order to synchronize the assembly of the cytosolic subunits on the membrane components of the oxidase, a fusion of the cytosolic proteins p47(phox), p67(phox) and Rac1 named trimera was constructed...
October 25, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29069584/dendritic-cell-amiloride-sensitive-channels-mediate-sodium-induced-inflammation-and-hypertension
#18
Natalia R Barbaro, Jason D Foss, Dmytro O Kryshtal, Nikita Tsyba, Shivani Kumaresan, Liang Xiao, Raymond L Mernaugh, Hana A Itani, Roxana Loperena, Wei Chen, Sergey Dikalov, Jens M Titze, Bjorn C Knollmann, David G Harrison, Annet Kirabo
Sodium accumulates in the interstitium and promotes inflammation through poorly defined mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through amiloride-sensitive channels including the alpha and gamma subunits of the epithelial sodium channel and the sodium hydrogen exchanger 1. This leads to calcium influx via the sodium calcium exchanger, activation of protein kinase C (PKC), phosphorylation of p47phox , and association of p47phox with gp91phox . The assembled NADPH oxidase produces superoxide with subsequent formation of immunogenic isolevuglandin (IsoLG)-protein adducts...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/29043330/procyanidins-extracted-from-the-litchi-pericarp-ameliorate-atherosclerosis-in-apoe-knockout-mice-their-effects-on-nitric-oxide-bioavailability-and-oxidative-stress
#19
Shuang Rong, Xueting Hu, Siqi Zhao, Yanting Zhao, Xiao Xiao, Wei Bao, Liegang Liu
Epidemiological studies strongly support the role of procyanidin-rich beverages and fruit in the prevention of cardiovascular diseases. Procyanidins extracted from the litchi pericarp (LPPC), a new source of procyanidins, were isolated and identified in our laboratory and have been proven to possess strong antioxidant activity in vitro. In the present study, we investigated the anti-atherosclerotic effects of LPPC in apolipoprotein E knockout (ApoE KO) mice fed a high fat diet for 24 weeks. LPPC (100 mg kg(-1) body mass daily) significantly reduced the atherosclerotic lesion size (P < 0...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29042313/the-hypothetical-protein-p47-of-clostridium-botulinum-e1-strain-beluga-has-a-structural-topology-similar-to-bactericidal-permeability-increasing-protein
#20
Kwok-Ho Lam, Ruifeng Qi, Shun Liu, Amelie Kroh, Guorui Yao, Kay Perry, Andreas Rummel, Rongsheng Jin
Botulinum neurotoxins (BoNTs) are causative agents of the life-threatening disease botulism. They are naturally produced by species of the bacteria Clostridium botulinum as stable and non-covalent complexes, in which the BoNT molecule is assembled with several auxiliary non-toxic proteins. Some BoNT serotypes, represented by the well-studied BoNT serotype A (BoNT/A), are produced by Clostridium strains that carry the ha gene cluster, which encodes four neurotoxin-associated proteins (NTNHA, HA17, HA33, and HA70) that play an important role to deliver and protect BoNTs in the gastrointestinal tract during oral intoxication...
October 16, 2017: Toxicon: Official Journal of the International Society on Toxinology
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