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https://www.readbyqxmd.com/read/27917630/a-novel-cybb-mutation-in-chronic-granulomatous-disease-in-iran
#1
Shaghayegh Tajik, Mohsen Badalzadeh, Mohammad Reza Fazlollahi, Massoud Houshmand, Fariborz Zandieh, Shamim Khandan, Zahra Pourpak
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder due to a genetic defect in one of the components of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This complex is composed of membrane-bound gp91-phox and p22-phox subunits, and cytosolic subunits consisting of p47-phox, p67-phox, and p40-phox. A mutation in CYBB gene encoding gp91-phox located on chromosome Xp21.1, leads to X-linked CGD. Herein, we report a 4-year-old Iranian boy presented with episodes of recurrent fever, cervical lymphadenopathy, and abdominal abscesses...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27910549/developments-of-scintillator-based-soft-x-ray-diagnostic-in-lhd-with-csi-tl-and-p47-scintillators
#2
T Bando, S Ohdachi, Y Suzuki
Multi-channel soft x-ray (SX) diagnostic has been used in the large helical device (LHD) to research magnetohydrodynamic equilibria and activities. However, in the coming deuterium plasma experiments of LHD, it will be difficult to use semiconductor systems near LHD. Therefore, a new type of SX diagnostic, a scintillator-based type diagnostic, has been investigated in order to avoid damage from the radiation. A fiber optic plate coated by P47 scintillator will be used to detect SX emission. Scintillation light will be transferred by pure silica core optical fibers and detected by photomultiplier tubes...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27876813/oncogenic-transformation-of-human-lung-bronchial-epithelial-cells-induced-by-arsenic-involves-ros-dependent-activation-of-stat3-mir-21-pdcd4-mechanism
#3
Poyil Pratheeshkumar, Young-Ok Son, Sasidharan Padmaja Divya, Lei Wang, Zhuo Zhang, Xianglin Shi
Arsenic is a well-documented human carcinogen. The present study explored the role of the onco-miR, miR-21 and its target protein, programmed cell death 4 (PDCD4) in arsenic induced malignant cell transformation and tumorigenesis. Our results showed that treatment of human bronchial epithelial (BEAS-2B) cells with arsenic induces ROS through p47(phox), one of the NOX subunits that is the key source of arsenic-induced ROS. Arsenic exposure induced an upregulation of miR-21 expression associated with inhibition of PDCD4, and caused malignant cell transformation and tumorigenesis of BEAS-2B cells...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27849390/adverse-effects-of-tempol-on-hidrosaline-balance-in-rats-with-acute-sodium-overload
#4
N M Kouyoumdzian, Nl Rukavina Mikusic, G Cao, M R Choi, Sl Della Penna, B E Fernández, J E Toblli, M I Rosón
We studied the effects of tempol, an oxygen radical scavenger, on hydrosaline balance in rats with acute sodium overload. Male rats with free access to water were injected with isotonic (control group) or hypertonic saline solution (0.80 mol/l NaCl) either alone (Na group) or with tempol (Na-T group). Hydrosaline balance was determined during a 90 min experimental period. Protein expressions of aquaporin 1 (AQP1), aquaporin 2 (AQP2), angiotensin II (Ang II) and endothelial nitric oxide synthase (eNOS) were measured in renal tissue...
November 2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/27809835/anvillea-garcinii-extract-inhibits-the-oxidative-burst-of-primary-human-neutrophils
#5
Hanane Boukemara, Margarita Hurtado-Nedelec, Viviana Marzaioli, Dalila Bendjeddou, Jamel El Benna, Jean-Claude Marie
BACKGROUND: Anvillea garcinii Coss. & Durieu (Anv) plant is used as a traditional North African medicine against several diseases associated with inflammation. At inflammatory sites, reactive oxygen species (ROS) produced in excess by activated phagocyte NADPH oxidase (NOX2) can accentuate inflammatory responses. Thus, we investigated if Anv-water soluble polysaccharides could modulate primary human neutrophil oxidative burst in vitro. METHODS: Human neutrophils were isolated from fresh whole blood and O2(...
November 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27793734/reversal-of-ethanol-induced-hepatotoxicity-by-cinnamic-and-syringic-acids-in-mice
#6
Sheng-Lei Yan, Zhi-Hong Wang, Hsiu-Fang Yen, Yi-Ju Lee, Mei-Chin Yin
Ethanol was used to induce acute hepatotoxicity in mice. Effects of cinnamic acid (CA) and syringic acid (SA) post-intake for hepatic recovery from alcoholic injury was investigated. Ethanol treated mice were supplied by CA or SA at 40 or 80 mg/kg BW/day for 5 days. Results showed that ethanol stimulated protein expression of CYP2E1, p47(phox), gp91(phox), cyclooxygenase-2 and nuclear factor kappa B in liver. CA or SA post-intake restricted hepatic expression of these molecules. Ethanol suppressed nuclear factor erythroid 2-related factor (Nrf2) expression, and CA or SA enhanced Nrf2 expression in cytosolic and nuclear fractions...
October 25, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27785701/the-opposite-role-of-two-uba-ubx-containing-proteins-p47-and-saks1-in-the-degradation-of-a-single-erad-substrate-%C3%AE-tcr
#7
Eun Sil Park, Yung Joon Yoo, Muthukumar Elangovan
The UBA-UBX domain-containing proteins can interact with ubiquitinated substrates and p97 during endoplasmic reticulum-associated degradation (ERAD). Here, we found that the expressions of all UBA-UBX genes p47, SAKS1, UBXD8, FAF1, and UBXD7 were elevated upon ER stress, albeit with different levels. Of which p47, SAKS1, and UBXD8 are 'immediate' respondents whereas FAF1 and UBXD7 were 'late' respondents to ER stress. Interestingly, the expression of specific UBA-UBX genes were altered in cells stably expressing three different ERAD substrates such as α-TCR, α1-antitrypsin, and δCD3...
October 26, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27765769/microvascular-endothelial-dysfunction-in-sedentary-obese-humans-is-mediated-by-nadph-oxidase-influence-of-exercise-training
#8
Justin D La Favor, Gabriel S Dubis, Huimin Yan, Joseph D White, Margaret A M Nelson, Ethan J Anderson, Robert C Hickner
OBJECTIVE: The objectives of this study were to determine the impact of in vivo reactive oxygen species (ROS) on microvascular endothelial function in obese human subjects and the efficacy of an aerobic exercise intervention on alleviating obesity-associated dysfunctionality. APPROACH AND RESULTS: Young, sedentary men and women were divided into lean (body mass index 18-25; n=14), intermediate (body mass index 28-32.5; n=13), and obese (body mass index 33-40; n=15) groups...
December 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27754346/gallic-acid-content-in-taiwanese-teas-at-different-degrees-of-fermentation-and-its-antioxidant-activity-by-inhibiting-pkc%C3%AE-activation-in-vitro-and-in-silico-studies
#9
Teeradate Kongpichitchoke, Ming-Tzu Chiu, Tzou-Chi Huang, Jue-Liang Hsu
Teas can be classified according to their degree of fermentation, which has been reported to affect both the bioactive components in the teas and their antioxidative activity. In this study, four kinds of commercial Taiwanese tea at different degrees of fermentation, which include green (non-fermented), oolong (semi-fermented), black (fully fermented), and Pu-erh (post-fermented) tea, were profiled for catechin levels by using high performance liquid chromatography (HPLC). The result indicated that the gallic acid content in tea was directly proportional to the degree of fermentation in which the lowest and highest gallic acid content were 1...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27754300/lbos-02-01-hypertension-aldosterone-and-epc-mediated-endothalial-injury-repair
#10
Jun Tao
OBJECTIVE: Hyperaldosteronemia exerts adverse effects on vascular endothelium except enhanceing blood pressure; however, the impacts and molecular mechanisms of hyperaldosteronemia on endothelial progenitor cell (EPC)-mediated endothelial repair are yet to be determined. The aim of this study was to investigate the endothelial repair capacity of EPCs from hypertensive patients with primary hyperaldosteronemia (PHA). DESIGN AND METHOD: In vivo endothelial repair capacity of EPCs from PHAs (n = 20), age- and blood pressure-matched essential hypertension patients (n = 20), and age-matched healthy subjects (n = 20) was evaluated by transplantation into nude mice with carotid artery denudation injury...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753901/os-02-01-role-of-aldosterone-and-nadph-oxidase-1-in-hypertension-associated-vascular-aging
#11
Adam P Harvey, Augusto Montezano, Khai C Wong, Katie Y Hood, Rheure Alves-Lopes, Graziela S Ceravolo, Chihiro Yabe-Nishimura, Delyth Graham, Rhian M Touyz
OBJECTIVE: In hypertension, the vasculature undergoes alterations that resemble those seen in aging. The involvement of aldosterone and Noxs in the mechanisms underlying age-associated vascular damage is unclear. We postulated that aging-like changes in the vasculature is amplified in hypertension due to increased aldosterone-induced Nox-redox signalling. DESIGN AND METHOD: We assessed vascular aging in arteries from adult WKY (18 weeks), aged WKY (52 weeks) and adult stroke-prone spontaneously hypertensive (SHRSP) rats...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27731349/trpm2-regulates-txnip-mediated-nlrp3-inflammasome-activation-via-interaction-with-p47-phox-under-high-glucose-in-human-monocytic-cells
#12
Hisa Hui Ling Tseng, Chi Teng Vong, Yiu Wa Kwan, Simon Ming-Yuen Lee, Maggie Pui Man Hoi
Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1β (IL-1β), which contributes to the pathogenesis of diabetes and its complications. Although high glucose (HG)-induced oxidative stress and aberrant Ca(2+) channels activity causes an increase in transmembrane Ca(2+) influx, however the relative contribution of Transient receptor potential (TRP) channels is not well studied. Here, we identified that HG (30 mM glucose for 48 h) induced the activation of the NLRP3-ASC inflammasome, leading to caspase-1 activation, and IL-1β and IL-18 secretion in human monocytic cell lines...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27717730/l-arginine-supplementation-improves-insulin-sensitivity-and-beta-cell-function-in-the-offspring-of-diabetic-rats-through-akt-and-pdx-1-activation
#13
Diego Soares Carvalho, Marilia Melo Diniz, André Abour Haidar, Maria de Fátima Cavanal, Eduardo da Silva Alves, Angelo Rafael Carpinelli, Frida Zaladek Gil, Aparecida Emiko Hirata
Maternal hyperglycemia can result in defects in glucose metabolism and pancreatic β-cell function in offspring. The purpose of this study was to evaluate the impact of maternal diabetes mellitus on pancreatic islets, muscle and adipose tissue of the offspring, with or without oral l-Arginine supplementation. The induction of diabetes was performed using streptozotocin (60mg/kg). Animals were studied at 3 months of age and treatment (sucrose or l-Arginine) was administered from weaning. We observed that l-Arg improved insulin sensitivity in the offspring of diabetic mothers (DA), reflected by higher insulin-induced phosphorylation of Akt in muscle and adipose tissue...
October 4, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27699571/clinical-immunological-and-molecular-findings-of-patients-with-p47-phox-defect-chronic-granulomatous-disease-cgd-in-indian-families
#14
Manasi Kulkarni, Mukesh Desai, Maya Gupta, Aparna Dalvi, Prasad Taur, Antony Terrance, Sunil Bhat, Mamta Manglani, Revathi Raj, Ira Shah, Manisha Madkaikar
Chronic granulomatous disease (CGD) is a group of inherited disorder of phagocytes, resulting from mutations in the components of the NADPH oxidase complex. Reduced or absent oxygen radical synthesis seen in these patients leads to impaired killing of intracellular bacteria and fungi. CGD clinically presents with recurrent and life-threatening infections as well as granulomatous inflammatory responses. p47(phox) encoded by the NCF1 gene is the most common autosomal recessive form of CGD which is often clinically milder...
October 3, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27698952/epigallocatechin-3-gallate-attenuates-renal-damage-by-suppressing-oxidative-stress-in-diabetic-db-db-mice
#15
Xiu Hong Yang, Yu Pan, Xiao Li Zhan, Bao Long Zhang, Li Li Guo, Hui Min Jin
Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity. In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells. EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II. Moreover, EGCG could also change the level of several parameters associated with oxidative stress. In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27679493/microrna-223-ameliorates-alcoholic-liver-injury-by-inhibiting-the-il-6-p47phox-oxidative-stress-pathway-in-neutrophils
#16
Man Li, Yong He, Zhou Zhou, Teresa Ramirez, Yueqiu Gao, Yanhang Gao, Ruth A Ross, Haixia Cao, Yan Cai, Mingjiang Xu, Dechun Feng, Ping Zhang, Suthat Liangpunsakul, Bin Gao
OBJECTIVES: Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver injury in mice. This study investigates how recent excessive drinking affects peripheral neutrophils and liver injury in alcoholics, and how miR-223, one of the most abundant microRNAs (miRNAs) in neutrophils, modulates neutrophil function and liver injury in ethanol-fed mice. DESIGNS: Three hundred alcoholics with (n=140) or without (n=160) recent excessive drinking and 45 healthy controls were enrolled...
September 27, 2016: Gut
https://www.readbyqxmd.com/read/27671463/interaction-between-lps-and-a-dental-resin-monomer-on-cell-viability-in-mouse-macrophages
#17
Helmut Schweikl, Matthias Widbiller, Stephanie Krifka, Johannes Klement, Christine Petzel, Carola Bolay, Karl-Anton Hiller, Wolfgang Buchalla
OBJECTIVE: Lipopolysaccharide (LPS) from cariogenic microorganisms and resin monomers like HEMA (2-hydroxyethyl methacrylate) included in dentin adhesive are present in a clinical situation in deep dentinal cavity preparations. Here, cell survival, expression of proteins related to redox homeostasis, and viability of mouse macrophages exposed to LPS and HEMA were analyzed with respect to the influence of oxidative stress. METHODS: Cell survival of RAW264.7 mouse macrophages was determined using a crystal violet assay, protein expression was detected by Western blotting, and HEMA- or LPS-induced apoptosis (cell viability) was analyzed by flow cytometry...
December 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27668493/in-vivo-angiography-quantifies-oxygen-induced-retinopathy-vascular-recovery
#18
Olachi J Mezu-Ndubuisi
PURPOSE: Retinopathy of prematurity (ROP) is a potentially blinding vasoproliferative disease. There is no standardized way to quantify plus disease (tortuous and dilated retinal vessels) or characterize abnormal recovery during ROP monitoring. This study objectively studies vascular features in live mice during development using noninvasive retinal imaging. METHODS: Using fluorescein angiography (FA), retinal vascular features were quantified in live mice with oxygen induced retinopathy (OIR)...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27665197/involvement-of-nadph-oxidase-and-nf-%C3%AE%C2%BAb-activation-in-cxcl1-induction-by-vascular-endothelial-growth-factor-in-human-endometrial-epithelial-cells-of-patients-with-adenomyosis
#19
Tsung-Hsuan Lai, Pi-Hui Wu, Wen-Bin Wu
Chemokines were known to participate in inflammation and angiogenesis but have been recently recognized to be involved in embryonic implantation and endometrium-related pathologies. Among these chemokines, the CXC chemokines, such as CXCL1, have potential roles to work as biomarkers to identify patients with uterine adenomyosis. In this study, human endometrial epithelial cells (HEECs) were derived from patients' endometrium with adenomyosis. The inductive effects of CXCL1 production by various mediators/growth factors were investigated in the HEECs...
September 3, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27660232/rice-bran-protein-hydrolysates-reduce-arterial-stiffening-vascular-remodeling-and-oxidative-stress-in-rats-fed-a-high-carbohydrate-and-high-fat-diet
#20
Ketmanee Senaphan, Weerapon Sangartit, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Patchareewan Pannangpetch, Supawan Thawornchinsombut, Stephen E Greenwald, Upa Kukongviriyapan
PURPOSE: Rice bran protein hydrolysates (RBPH) contain highly nutritional proteins and antioxidant compounds which show benefits against metabolic syndrome (MetS). Increased arterial stiffness and the components of MetS have been shown to be associated with an increased risk of cardiovascular disease. This study aimed to investigate whether RBPH could alleviate the metabolic disorders, arterial stiffening, vascular remodeling, and oxidative stress in rats fed a high-carbohydrate and high-fat (HCHF) diet...
September 22, 2016: European Journal of Nutrition
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