keyword
MENU ▼
Read by QxMD icon Read
search

candid

keyword
https://www.readbyqxmd.com/read/29458096/identification-of-macrophage-related-candidate-genes-in-lupus-nephritis-using-bioinformatics-analysis
#1
Bingyan Shu, Yi Fang, Weichun He, Junwei Yang, Chunsun Dai
Lupus nephritis (LN) is a chronic autoimmune disorder. Here we try to identify the candidate genes in macrophages related to LN. We performed a systematic search in the Gene Expression Omnibus (GEO) database for microarray in human mononuclear cells and mouse macrophages of LN. The results of clustering and venn analysis of different GEO datasets showed that 8 genes were up-regulated and 2 genes down-regulated in samples from both human and mouse LN. The data from gene network and GO analysis revealed that CD38 and CCL2 were localized in the core of the network...
February 16, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29458069/high-expression-of-nprl2-is-linked-to-poor-prognosis-in-patients-with-prostate-cancer
#2
Zhixiong Chen, Shengjun Luo, Yanlin Chen, Xuemei Xie, Zhongbo Du, Li Jiang
As a tumor suppressor candidate gene, NPRL2 has anti-cancer effects against several cancers, but its potential role in prostate cancer (PCa) has not been reported. The present study aimed to explore the expression of NPRL2 in PCa and its potential clinical significance. Our results showed that expression of NPRL2 in PCa tissues was significantly higher than in non-PCa tissues (P<.001). High NPRL2 expression in PCa tissue was significantly correlated with a high Gleason grade group (P<.001), high pT stage (P<...
February 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29458062/an-unexpected-degradation-pathway-of-a-1-2-4-triazolo-4-3-a-pyridine-derivative-the-formation-of-two-cationic-pseudodimers-of-an-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor-drug-candidate-in-a-stressed-capsule-formulation
#3
Yande Huang, Qinggang Wang, Yongmei Wu
Degradation of an active pharmaceutical ingredient (API), a 2-(3-(1-(4-chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)propan-2-ol hydrochloride salt, was observed in a capsule formulation stressed at 50°C or 40°C/75% relative humidity conditions for one month. Two unknown degradants were identified as cationic pseudodimers of the API via accurate mass liquid chromatography-mass spectrometry and one- and two-dimensional NMR analyses. A plausible degradation pathway of the API was postulated which led to the identification of two key N-oxide degradants in the stressed capsule formulation at trace levels...
February 16, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29458015/sulfenamide-and-sulfonamide-derivatives-of-metformin-can-exert-anti-coagulant-and-pro-fibrinolytic-properties
#4
Magdalena Markowicz-Piasecka, Kristiina M Huttunen, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik, Joanna Sikora
Type 2 diabetes mellitus (T2DM) is characterised not only by hyperglycaemia and insulin resistance but also an impaired balance between the processes of coagulation and fibrinolysis. The aim of this study was to examine the effects of metformin, a widely-used oral anti-diabetic drug, phenformin and eight sulfenamide and sulfonamide derivatives of metformin on several haemostasis parameters. Thrombin Time (TT) tests were performed according to the available commercial method. The activity of factor X was conducted based on deficient plasma factor X...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457992/ground-ultra-low-volume-ulv-space-spray-applications-for-the-control-of-wild-sand-fly-populations-psychodidae-phlebotominae-in-europe
#5
Alexandra Chaskopoulou, Michael Miaoulis, Javid Kashefi
The Phlebotomus sand flies are considered an important vector of both canine and human leishmaniasis. Current measures for sand fly control include mostly indoor interventions, such as residual spraying of dwellings (IRS) to target endophilic sand fly species with very limited number of vector control tools for outdoor interventions against exophilic sand flies. In this study we investigated the efficacy of ground ultra low volume (ULV) space spray applications of a deltamethrin based product against field populations of P...
February 16, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29457965/probing-in-plane-anisotropy-in-few-layer-res-2-using-low-frequency-noise-measurement
#6
Richa Mitra, Bhakti Jariwala, Arnab Bhattacharya, Anindya Das
ReS2 , a layered two-dimensional material popular for its in-plane anisotropic properties, is emerging as one of the potential candidates for flexible electronics and ultrafast optical applications. It is an n-type semiconducting material having a layer independent bandgap of 1.55 eV. In this paper we have characterized the intrinsic electronic noise level of few-layer ReS2 for the first time. Few-layer ReS2 field effect transistor devices show a 1/f nature of noise for frequency ranging over three orders of magnitude...
February 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29457930/nano-loaded-human-umbilical-cord-mesenchymal-stem-cells-as-targeted-carriers-of-doxorubicin-for-breast-cancer-therapy
#7
Shunxiu Cao, Jiamin Guo, Yujing He, Murad Alahdal, Shanshan Tang, Yuekui Zhao, Zhaocong Yang, Huashan Gao, Wenjun Hu, Hulin Jiang, Lianju Qin, Liang Jin
The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs...
February 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29457895/periodic-trends-in-actinyl-thio-crown-ether-complexes
#8
Shu-Xian Hu, Jing-Jing Liu, John K Gibson, Jun Li
In-cavity complexes and their bonding features between thio-crown (TC) ethers and f-elements are unexplored so far. In this paper, actinyl(VI) (An = U, Np, Pu, Am, and Cm) complexes of TC ethers have been characterized using relativistic density functional theory. The TC ether ligands include tetrathio-12-crown-4 (12TC4), pentathio-15-crown-5 (15TC5), and hexathio-18-crown-6 (18TC6). On the basis of the calculations, it is found that the "double-decker" sandwich structure of AnO2 (12TC4)2 2+ and "side-on" structure AnO2 (12TC4)2+ are changed to "insertion" structures for AnO2 (15TC5)2+ and AnO2 (18TC6)2+ due to increased size of the TC ether ligands...
February 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29457893/kinetics-thermodynamics-and-mechanism-of-a-novel-biphasic-solvent-for-co2-capture-from-flue-gas
#9
Shihan Zhang, Yao Shen, Peijing Shao, Jianmeng Chen, Lidong Wang
The main issue related to the deployment of amine-based absorption process for CO2 capture from flue gas is its intensive energy penalty. Therefore, this study screened a novel biphasic solvent, comprising a primary amine e.g., triethylenetetramine (TETA) and a tertiary amine e.g., N, N-dimethylcyclohexylamine (DMCA), to reduce the energy consumption. The TETA-DMCA blend exhibited high cyclic capacity of CO2 absorption, favorable phase separation behavior, and low regeneration heat. Kinetic analysis showed that the gas- and liquid-side mass transfer resistances were comparable in the lean solution of TETA-DMCA at 40oC, whereas the liquid-side mass transfer resistance became dominant in the rich solution...
February 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29457871/a-qtl-on-chromosome-1-modulates-inter-male-aggression-in-mice
#10
Anna Delprato, Brice Bonheur, Marie-Paule Algéo, Alba Murillo, Esha Dhawan, Lu Lu, Robert W Williams, Wim E Crusio
Aggression between male conspecifics is a complex social behavior that is likely modulated by multiple gene variants. In this study the BXD recombinant inbred mouse strains (RIS) were used to map quantitative trait loci (QTLs) underlying behaviors associated with intermale aggression. Four hundred and fifty-seven males from 55 strains (including the parentals) were observed at an age of 13 +/- 1 week in a resident-intruder test following 10 days of isolation. Attack latency was measured directly within a 10 minute time period and the test was repeated 24 hours later...
February 19, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#11
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29457828/dihydrodiosgenin-protects-against-experimental-acute-pancreatitis-and-associated-lung-injury-through-mitochondrial-protection-and-pi3k%C3%AE-akt-inhibition
#12
Yan Shen, Li Wen, Rui Zhang, Zeliang Wei, Na Shi, Qiuyang Xiong, Qing Xia, Zhihua Xing, Zhi Zeng, Hai Niu, Wen Huang
BACKGROUND AND PURPOSE: Acute pancreatitis (AP) is a painful and burdensome exocrine pancreatic disorder with no specific drug treatment. Diosgenyl saponin extracts from Dioscorea zingiberensis C. H. Wright were reported to protect against experimental models of AP and diosgenin or its derivatives have anti-inflammatory effects in various diseases. However, the effects of diosgenin and its spiroacetal ring opened analog dihydrodiosgenin (Dydio) have not yet been determined in AP. EXPERIMENTAL APPROACH: Various concentrations of diosgenin and Dydio were tested for sodium taurocholate hydrate (Tauro)-induced necrosis in freshly isolated murine pancreatic acinar cells...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457562/quality-of-life-outcomes-in-cochlear-implantation-of-children-with-profound-and-multiple-learning-disability
#13
Richard Benjamin Speaker, Jennifer Roberston, Cristina Simoes-Franklin, Fergal Glynn, Peter Walshe, Laura Viani
This study was performed to investigate the effect of cochlear implantation on the Quality of Life (QoL) of children with profound and multiple learning disability (PMLD). This cohort of children has been viewed historically as poor candidates for cochlear implantation as they generally have poor speech and hearing outcomes. The Irish National Cochlear Implant Program's prospectively maintained database was examined for all children implanted from July 1996 to July 2015. All charts of the 381 children implanted during this time were reviewed retrospectively; 16 children met criteria for being PMLD...
May 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29457458/amphiphilic-functionalized-acupuncture-needle-as-sers-sensor-for-in-situ-multiphase-detection
#14
Binbin Zhou, Mei Mao, Xiaomin Cao, Meihong Ge, Xianghu Tang, Shaofei Li, Dongyue Lin, LiangBao Yang, Jinhuai Liu
Surface enhanced Raman spectroscopy (SERS) is a powerful spectroscopic technique with unique vibrational fingerprints, making it an ideal candidate for in situ multiphase detection. However, it is a great challenges that how to guide the SERS sensor to targets molecule of interest in multiphase heterogeneous samples with minimally disturbance. Here, we present a portable ultrasensitive and highly repeatable SERS sensor for in situ multiphase detection. The sensor is composed of com-mercial Ag acupuncture needle and PVP-Au nanoparticles (Au NPs)...
February 19, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29457445/model-for-end-stage-liver-disease-and-seven-derivations-to-prioritize-liver-transplant-candidates-which-is-the-winner
#15
Fariba Tohidinezhad, Saeid Eslami, Ameen Abu-Hanna, Mohsen Aliakbarian
OBJECTIVES: Under the present liver transplant policy, patients with the highest risk of death receive preference for organ placement. The aim of this study was to evaluate the Model for End-stage Liver Disease (MELD) and seven prognostic derivatives of this test for outcome prediction in cirrhotic patients on liver transplant wait lists. MATERIAL AND METHODS: The study included 416 patients (65.9% male; age 49 ± 13.9 years) who were entered to liver transplant wait lists from January 2013 to October 2016...
February 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29457293/ginsenoside-rh2-inhibits-prostate-cancer-cell-growth-through-suppression-of-microrna-4295-that-activates-cdkn1a
#16
Qiruo Gao, Junhua Zheng
OBJECTIVES: Ginsenoside Rh2 (GRh2) has demonstrative therapeutic effects on a variety of diseases, including some tumours. However, the effects of GRh2 on prostate cancer (PC) cell growth remain unknown, and were, thus, addressed in the present study. MATERIALS AND METHODS: PC3 and DU145 PC cell lines were exposed to GRh2. Cell proliferation was assessed in an MTT assay and by BrdU incorporation. Apoptosis of the cells were assessed by TUNEL staining. Total RNA was assessed by RT-qPCR...
February 19, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29457274/impact-of-the-kidney-allocation-system-on-young-pediatric-recipients
#17
W F Parker, L F Ross, J R Thistlethwaite, A E Gallo
The Kidney Allocation System (KAS) altered pediatric candidate prioritization. We determined KAS' impact on pediatric kidney recipients by examining delayed graft function (DGF) rates from 2010-2016. A propensity score matched pediatric recipients pre- and post-KAS. A semi-parametric decomposition analysis estimated the contributions of KAS-related changes in donor characteristics and dialysis time on DGF rate. The unadjusted odds of DGF was 69% higher post-KAS for young (<10 years at listing) recipients (N = 1,153, p=0...
February 19, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29457256/innovation-in-values-based-public-health-nursing-student-selection-a-qualitative-evaluation-of-candidate-and-selection-panel-member-perspectives
#18
Caroline McGraw, Stephen Abbott, Judy Brook
OBJECTIVES: Values based recruitment emerges from the premise that a high degree of value congruence, or the extent to which an individual's values are similar to those of the health organization in which they work, leads to organizational effectiveness. The aim of this evaluation was to explore how candidates and selection panel members experienced and perceived innovative methods of values based public health nursing student selection. DESIGN AND SAMPLE: The evaluation was framed by a qualitative exploratory design involving semi-structured interviews and a group exercise...
February 19, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29457194/reproduction-in-woody-perennial-citrus-an-update-on-nucellar-embryony-and-self-incompatibility
#19
REVIEW
Siqi Zhang, Mei Liang, Nan Wang, Qiang Xu, Xiuxin Deng, Lijun Chai
Review on citrus reproduction. Citrus is one of the most important and widely grown fruit crops. It possesses several special reproductive characteristics, such as nucellar embryony and self-incompatibility. The special phenomenon of nucellar embryony in citrus, also known as the polyembryony, is a kind of sporophytic apomixis. During the past decade, the emergence of novel technologies and the construction of multiple citrus reference genomes have facilitated rapid advances to our understanding of nucellar embryony...
February 19, 2018: Plant Reproduction
https://www.readbyqxmd.com/read/29456985/evaluation-of-mir-21-inhibition-and-its-impact-on-cancer-susceptibility-candidate-2-long-noncoding-rna-in-colorectal-cancer-cell-line
#20
Miganoosh Simonian, Mohammadreza Sharifi, Reza Nedaeinia, Meysam Mosallaie, Sharifeh Khosravi, Amir Avan, Majid Ghayour-Mobarhan, Hadi Bagheri, Rasoul Salehi
Background: Both microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been shown to have a critical role in the regulation of cellular processes such as cell growth and apoptosis, as well as cancer progression and metastasis. lncRNAs are aberrantly expressed in many diseases including cancer. Although it is well known that miRNAs can target a large number of protein-coding genes, little is known whether miRNAs can also target lncRNAs. In the present study, we determine whether miR-21 can regulate lncRNA cancer susceptibility candidate 2 (CASC2) in colorectal cancer...
2018: Advanced Biomedical Research
keyword
keyword
86771
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"