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https://www.readbyqxmd.com/read/28434095/patient-reported-outcomes-in-cancer-survivors-a-population-wide-cross-sectional-study
#1
Michael Jefford, Andrew C Ward, Karolina Lisy, Karen Lacey, Jon D Emery, Adam W Glaser, Hannah Cross, Mei Krishnasamy, Sue-Anne McLachlan, Jim Bishop
PURPOSE: There is a lack of robust population-based data regarding the lived experience of cancer survivors. This study assessed the quality of life (QoL) of survivors of breast, colorectal, or prostate cancer, non-Hodgkin lymphoma or melanoma 1, 3 and 5 years post-diagnosis. Associations between various demographic and disease-related factors and QoL were assessed. METHODS: A cross-sectional postal survey was undertaken. Eligible participants were identified from a population-based cancer registry...
April 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28433950/an-electrocortical-investigation-of-emotional-face-processing-in-military-related-posttraumatic-stress-disorder
#2
Julia A DiGangi, Katie L Burkhouse, Darrin M Aase, Joseph M Babione, Christopher Schroth, Amy E Kennedy, Justin E Greenstein, Eric Proescher, K Luan Phan
PTSD is a disorder of emotion dysregulation. Although much work has intended to elucidate the neural underpinnings of the disorder, much remains unknown about the neurobiological substrates of emotion dysregulation in PTSD. In order to assess the relationship between a neural measure of attention to emotion (i.e. the late positive potential; LPP) and PTSD symptoms, EEG was recorded and examined as a potential predictor of military-related PTSD symptoms in a sample of 73 OEF/OIF/OND veterans. Results revealed that higher PTSD symptoms were related to an attenuated LPP response to angry facial expressions...
March 20, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28433788/regulation-of-human-nucleus-pulposus-cells-by-peptide-coupled-substrates
#3
Devin T Bridgen, Bailey V Fearing, Liufang Jing, Johannah Sanchez-Adams, Megan C Cohan, Farshid Guilak, Jun Chen, Lori A Setton
Nucleus pulposus (NP) cells are derived from the notochord and differ from neighboring cells of the intervertebral disc in phenotypic marker expression and morphology. Adult human NP cells lose this phenotype and morphology with age in a pattern that contributes to progressive disc degeneration and pathology. Select laminin-mimetic peptide ligands and substrate stiffnesses were examined for their ability to regulate human NP cell phenotype and biosynthesis through the expression of NP-specific markers aggrecan, N-cadherin, collagen types I and II, and GLUT1...
April 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28433090/neural-biomarker-and-early-temperament-predict-increased-internalizing-symptoms-after-a%C3%A2-natural-disaster
#4
Alexandria Meyer, Carla Kmett Danielson, Allison P Danzig, Vickie Bhatia, Sarah R Black, Evelyn Bromet, Gabrielle Carlson, Greg Hajcak, Roman Kotov, Daniel N Klein
OBJECTIVE: Although most people will experience a traumatic event at some point in their life, only some will develop significant psychological symptoms in the aftermath. In the current study, we use a preexisting longitudinal study located in Long Island to examine the impact of Hurricane Sandy on internalizing symptoms in a large sample of children. We focused on temperamental fear and a biomarker of risk for anxiety, the error-related negativity (ERN). The ERN is a negative deflection in the event-related potential (ERP) occurring when individuals make mistakes and is increased in anxious individuals...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28432748/future-challenges-and-therapeutic-opportunities-in-type-2-diabetes-changing-the-paradigm-of-current-therapy
#5
REVIEW
D R Owens, L Monnier, A H Barnett
Most algorithms for type 2 diabetes mellitus (T2DM) do not recommend treatment escalation until glycated haemoglobin (HbA1c) fails to reach the recommended target of 7% (53 mmol/mol) within approximately 3 months on any treatment regimen ('treat to failure'). Clinical inertia and/or poor adherence to therapy contribute to patients not reaching glycaemic targets when managed according to this paradigm. Clinical inertia exists across the entire spectrum of anti-diabetes therapies, although it is most pronounced when initiating and optimizing insulin therapy...
April 21, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28432506/elective-colectomy-for-diverticulitis-in-transplant-patients-is-it-worth-the-risk
#6
Janet T Lee, Steve Skube, Genevieve B Melton, Mary R Kwaan, Christine C Jensen, Robert D Madoff, Wolfgang B Gaertner
BACKGROUND: The aim of this study was to determine morbidity and mortality for transplant patients undergoing elective colectomy for diverticulitis and determine the impact of recurrent diverticulitis on postoperative complications. METHODS: We identified transplant recipients that underwent elective colectomy for diverticulitis between 2000 and 2015 at a tertiary care institution. Patient and procedure variables, postoperative complications, length of stay, 30-day readmission, and mortality were identified through retrospective chart review...
April 21, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28432089/preparing-future-doctors-for-palliative-care-views-of-course-organisers
#7
Steven Walker, Jane Gibbins, Paul Paes, Stephen Barclay, Astrid Adams, Madawa Chandratilake, Faye Gishen, Philip Lodge, Bee Wee
BACKGROUND: Effective training at medical school is essential to prepare new doctors to safely manage patients with palliative care (PC) and end of life care (EOLC) needs. The contribution of undergraduate PC course organisers is central but their collective views regarding role are unknown. OBJECTIVE: To survey attitudes of PC course organisers regarding their course, organisation, the adequacy of training provided and level of personal satisfaction. METHODS: An anonymised, multifactorial, web-based questionnaire was devised, tested, modified and then sent to lead PC course organisers at all UK medical schools...
April 21, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28431906/transgenic-mice-with-increased-astrocyte-expression-of-ccl2-show-altered-behavioral-effects-of-alcohol
#8
Jennifer G Bray, Amanda J Roberts, Donna L Gruol
Emerging research provides strong evidence that activation of CNS glial cells occurs in neurological diseases and brain injury and results in elevated production of neuroimmune factors. These factors can contribute to pathophysiological processes that lead to altered CNS function. Recently, studies have also shown that both acute and chronic alcohol consumption can produce activation of CNS glial cells and the production of neuroimmune factors, particularly the chemokine CCL2. The consequences of alcohol-induced increases in CCL2 levels in the CNS have yet to be fully elucidated...
April 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28431170/early-total-enteral-feeding-in-stable-very-low-birth-weight-infants-a-before-and-after-study
#9
Sushma Nangia, Amit Bishnoi, Ankita Goel, Piali Mandal, Soumya Tiwari, Arvind Saili
Background: Fear of necrotizing enterocolitis (NEC) has perpetuated delayed initiation and slow advancement of enteral feeding in very low birth weight (VLBW) infants with inherent risks of parenteral alimentation. The objective of this study was to assess effect of early total enteral feeding (ETEF) on day of achievement of full enteral feeds, feed intolerance, NEC and sepsis. Methods: In total, 208 stable VLBW neonates (28-34 weeks) admitted during 6 month periods of three consecutive years were enrolled...
April 18, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28430628/critical-role-of-matrix-metallopeptidase-9-in-postoperative-cognitive-dysfunction-and-age-dependent-cognitive-decline
#10
Jiangjiang Bi, Weiran Shan, Ailin Luo, Zhiyi Zuo
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neuroinflammation is an important pathological process for POCD. However, it is not clear how systemic inflammation induced by surgery on peripheral tissues or organs is transmitted into the brain. We determined whether matrix metallopeptidase 9 (MMP9), a protein that can increase blood-brain barrier permeability, is critical in this transmission. The role of MMP9 in age-dependent cognitive decline was also determined...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430606/ketamine-administered-pregnant-rats-impair-learning-and-memory-in-offspring-via-the-creb-pathway
#11
Xinran Li, Cen Guo, Yanan Li, Lina Li, Yuxin Wang, Yiming Zhang, Yue Li, Yu Chen, Wenhan Liu, Li Gao
Ketamine has been reported to impair the capacity for learning and memory. This study examined whether these capacities were also altered in the offspring and investigated the role of the CREB signaling pathway in pregnant rats, subjected to ketamine-induced anesthesia. On the 14th day of gestation (P14), female rats were anesthetized for 3 h via intravenous ketamine injection (200 mg/Kg). Morris water maze task, contextual and cued fear conditioning, and olfactory tasks were executed between the 25th to 30th day after birth (B25-30) on rat pups, and rats were sacrificed on B30...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430404/understanding-asexual-identity-as-a-means-to-facilitate-culturally-competent-care-a-systematic-literature-review
#12
REVIEW
Catriona Jones, Mark Hayter, Julie Jomeen
AIMS AND OBJECTIVES: This paper aims to provide a contemporary overview of asexuality and the implications this has for health care practice. BACKGROUND: Individuals belonging to sexual minority groups face many barriers in accessing appropriate health care. The term 'sexual minority group' is usually used to refer to Lesbian Gay Bisexual and Transgender (LGBT) individuals. Anecdotal and research evidence suggests that those who identify as asexual have similar poor experiences...
April 21, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28430013/barriers-to-access-to-sterile-syringes-as-perceived-by-pharmacists-and-injecting-drug-users-implications-for-harm-reduction-in-lebanon
#13
Ali Ghaddar, Karine Nassar, Ghadier Elsoury
BACKGROUND: Access to sterile syringes to injecting drug users (IDU) reduces sharing behavior and prevents the transmission of HIV. OBJECTIVES: To describe the barriers to access to sterile syringes for IDUs in Lebanon from the perspectives of pharmacists and IDUs. METHODS: in this qualitative study conducted in Lebanon, data were collected from 72 syringe purchase tests at pharmacies, 64 interviewees with pharmacists and 2 focus groups with injecting drug users...
April 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28429707/the-human-amygdala-parametrically-encodes-the-intensity-of-specific-facial-emotions-and-their-categorical-ambiguity
#14
Shuo Wang, Rongjun Yu, J Michael Tyszka, Shanshan Zhen, Christopher Kovach, Sai Sun, Yi Huang, Rene Hurlemann, Ian B Ross, Jeffrey M Chung, Adam N Mamelak, Ralph Adolphs, Ueli Rutishauser
The human amygdala is a key structure for processing emotional facial expressions, but it remains unclear what aspects of emotion are processed. We investigated this question with three different approaches: behavioural analysis of 3 amygdala lesion patients, neuroimaging of 19 healthy adults, and single-neuron recordings in 9 neurosurgical patients. The lesion patients showed a shift in behavioural sensitivity to fear, and amygdala BOLD responses were modulated by both fear and emotion ambiguity (the uncertainty that a facial expression is categorized as fearful or happy)...
April 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28429581/nighttime-is-the-worst-time-parental-fear-of-hypoglycemia-in-young-children-with-type-1-diabetes
#15
Michelle A Van Name, Marisa E Hilliard, Claire T Boyle, Kellee M Miller, Daniel J DeSalvo, Barbara J Anderson, Lori M Laffel, Stephanie E Woerner, Linda A DiMeglio, William V Tamborlane
BACKGROUND: Fear of hypoglycemia is common in parents of young children with type 1 diabetes (T1D), but little is known about the specific fears that parents most often experience. Hypoglycemia fear has been associated with poorer glycemic control in older children, though not yet studied in a large cohort of very young children. MATERIALS AND METHODS: Parents of 549 children <7 years (mean 5.2 ± 1.2 years [19% <3 years]) with a mean diabetes duration of 2...
April 21, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28429376/daily-crying-prevalence-and-associated-factors-in-older-adult-persons-living-in-nursing-homes-findings-from-a-regional-study
#16
Alvisa Palese, Arianna Simeoni, Antonio Ranieri Zuttion, Barbara Ferrario, Sandra Ponta, Elisa Ambrosi
OBJECTIVES: The study aims to evaluate the prevalence of nursing home (NH) resident crying and associated factors at the individual and NH levels. DESIGN: A regional retrospective study design has been used. PARTICIPANTS AND SETTING: A total of 8875 residents, living in 105 NHs, were included. MEASUREMENTS: The occurrence of an episode of crying on at least a daily basis in the last month was the dependent variable; independent variables were set at individual and at the NH levels as reported in the Val...
April 21, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28427018/left-or-right-lateralizing-temporal-lobe-epilepsy-by-dynamic-amygdala-fmri
#17
Victoria Ives-Deliperi, James Thomas Butler, Hennric Jokeit
OBJECTIVES: In this case series, the findings of 85 functional MRI studies employing a dynamic fearful face paradigm are reported. Previous findings have shown the paradigm to generate bilateral amygdala activations in healthy subjects and unilateral activations in patients with MTLE, in the contralateral hemisphere to seizure origin. Such findings suggest ipsilateral limbic pathology and offer collateral evidence in lateralizing MTLE. METHODS: The series includes 60 patients with TLE, 12 patients with extra-temporal lobe epilepsy, and 13 healthy controls...
April 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28426969/chemogenetic-interrogation-of-a-brain-wide-fear-memory-network-in-mice
#18
Gisella Vetere, Justin W Kenney, Lina M Tran, Frances Xia, Patrick E Steadman, John Parkinson, Sheena A Josselyn, Paul W Frankland
Behavior depends on coordinated activity across multiple brain regions. Within such networks, highly connected hub regions are assumed to disproportionately influence behavioral output, although this hypothesis has not been systematically evaluated. Previously, by mapping brain-wide expression of the activity-regulated gene c-fos, we identified a network of brain regions co-activated by fear memory. To test the hypothesis that hub regions are more important for network function, here, we simulated node deletion in silico in this behaviorally defined functional network...
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426955/the-small-world-of-a-fear-memory
#19
Nicholas I Woods, Mazen A Kheirbek
How are fear memories organized? In this issue of Neuron, Vetere et al. (2017) take a network-based approach to demonstrate the importance of highly interconnected hub regions in the consolidation of a fear memory. By doing so, they provide an elegant framework for predicting behavior from functional network properties.
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426597/accommodating-immigrant-women-s-preferences-for-female-health-care-providers
#20
Christa Aubrey, Zubia Mumtaz, Patrick B Patterson, Radha Chari, B F Peter Mitchell
OBJECTIVE: To investigate obstetricians' perspectives of the importance, effect, and challenges of providing intrapartum care to immigrant women who request a female obstetrician. METHODS: A focused ethnography was conducted at a large teaching hospital, which serves a high proportion of immigrant clientele (predominantly North or East African, Middle Eastern, and South Asian) in Edmonton, Alberta, Canada. Data collection comprised single, semistructured interviews with a purposive sample of 20 obstetric health care providers (10 resident and 10 staff obstetricians)...
May 2017: Obstetrics and Gynecology
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