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https://www.readbyqxmd.com/read/29334658/contextual-determinants-of-psychopathology-the-singularity-of-attachment-as-a-predictor-of-mental-dysfunction
#1
Yolanda Alonso, Javier Fernández, Yolanda Fontanil, Esteban Ezama, Alberto Gimeno
The general aim of this research is to evaluate the singular weight of attachment relationships in psychopathology, to determine the point to which these relationships cannot be subsumed by other variables that are famously related to attachment, such as experience of stressful life events, social support, and coping styles. 172 people treated in mental health centers provided data related to these four aspects and about manifestations of psychopathology. Multiple linear regression analyses determined that 51% of the variance in the level of symptomatology is explained with six variables: two related to adult attachment (fear of rejection and abandonment in romantic relationships, and the degree of similarity to the fearful prototype), one related to social support (family appreciation), one to life events (overall perceived stress), and two to coping style (cognitive restructuring and social withdrawal)...
January 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29334194/enrollment-in-early-phase-clinical-trials-in-pediatric-oncology-the-experience-at-institut-curie
#2
Aurore Surun, Marie-Églantine Dujaric, Isabelle Aerts, Daniel Orbach, Irène Jiménez, Hélène Pacquement, Gudrun Schleiermacher, Franck Bourdeaut, Jean Michon, Jean-Claude K Dupont, François Doz
BACKGROUND: The European Paediatric Regulation was introduced in 2007 to facilitate access to new medicines for children. Our study explored accessibility of early-phase trials in pediatric oncology, in line with the European Paediatric Regulation, to identify the reasons for not inviting patients to participate, parents' refusal, or inclusion failure. PROCEDURE: We conducted a retrospective chart review at Institut Curie, Paris, for all pediatric patients whose cancer progressed despite known effective treatments between July 2010 and December 2013...
January 15, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29333887/physical-and-psychological-abuse-among-seropositive-african-american-msm-50-aged-years-and-older
#3
Christopher Lance Coleman
Little is known about abuse experienced among African American men who have sex with men (MSM) who are 50 years and older. A series of focus groups were conducted to examine perspectives of seropositive African American MSM age 50 years and older who reported experiencing some form of psychological or physical abuse. Thirty African American MSM were divided into four focus groups and four themes emerged: "Fear Being Gay," "No One Else to Love Me," "Nowhere to Turn," and "Sexual Risk & Control." The data suggest there is a need to develop culturally tailored interventions for this population...
January 15, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29333487/activation-of-the-medial-prefrontal-cortex-reverses-cognitive-and-respiratory-symptoms-in-a-mouse-model-of-rett-syndrome
#4
C James Howell, Michael P Sceniak, Min Lang, Wenceslas Krakowiecki, Fatimah E Abouelsoud, Saloni U Lad, Heping Yu, David M Katz
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2; Amir et al., 1999), a transcriptional regulatory protein (Klose et al., 2005). Mouse models of RTT (Mecp2 mutants) exhibit excitatory hypoconnectivity in the medial prefrontal cortex (mPFC; Sceniak et al., 2015), a region critical for functions that are abnormal in RTT patients, ranging from learning and memory to regulation of visceral homeostasis (Riga et al...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29333482/flexibility-in-the-face-of-fear-hippocampal-prefrontal-regulation-of-fear-and-avoidance
#5
Justin M Moscarello, Stephen Maren
Generating appropriate defensive behaviors in the face of threat is essential to survival. Although many of these behaviors are 'hard-wired', they are also flexible. For example, Pavlovian fear conditioning generates learned defensive responses, such as conditioned freezing, that can be suppressed through extinction. The expression of extinguished responses is highly context-dependent, allowing animals to engage behavioral responses appropriate to the contexts in which threats are encountered. Likewise, animals and humans will avoid noxious outcomes if given the opportunity...
February 2018: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29332635/fear-of-hypoglycemia-in-patients-with-type-2-diabetes-the-role-of-interoceptive-accuracy-and-prior-episodes-of-hypoglycemia
#6
Jennifer Grammes, Manuela Schäfer, Andrea Benecke, Ulrike Löw, Alena-Lynn Klostermann, Thomas Kubiak, Michael Witthöft
OBJECTIVE: Fear of hypoglycemia (FoH) is a limiting factor for diabetes self-management and can have detrimental effects on quality of life. However, relatively little is known about its underlying mechanisms. In line with findings on patients with anxiety disorders, we hypothesized that interoceptive accuracy (IA) might be positively linked to FoH in patients with type 2 diabetes (T2DM). METHODS: 133 patients with T2DM were screened according to the extreme quartiles of the Hypoglycemia Fear Survey worry subscale (HFS-W)...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29332551/how-narratives-of-fear-shape-girls-participation-in-community-life-in-two-conflict-affected-populations
#7
Marni Sommer, Miguel Munoz-Laboy, Emily Wilkinson Salamea, Johanna Arp, Kathryn L Falb, Nadine Rudahindwa, Lindsay Stark
Numerous social factors shape girls' lives in conflict-affected settings, affecting their vulnerability to gender-based violence (GBV). Qualitative research methods were used to examine spaces of perceived safety and risk for girls living in two conflict-affected populations: camps in Ethiopia hosting primarily South Sudanese and Sudanese refugees and communities in eastern Democratic Republic of Congo. Three major themes emerged: (a) challenges around caregiver-child communication regarding development, sex, and sexual violence; (b) a typology of safe/risky spaces; and (c) the influence of male-dominated spaces on experiences and fear of GBV...
June 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332026/medicinal-plant-materials-in-the-treatment-of-anxiety-disorders-neurobiological-aspects
#8
Miłosz Jan Gołyszny, Ewa Obuchowicz
Context • Pathological anxiety, which affects approximately one-third of the world population, is an inadequate, irrational reaction of an organism to the environment and to a potential threat. Despite advancements in pharmacotherapy for anxiety disorders, further studies are still necessary to search for new substances possessing the desired anxiolytic effects, with as few unwanted effects as possible. Objective • This study intended to examine the characteristics of medicinal plant materials that exhibit anxiolytic properties, with a special emphasis on the mechanisms of action of their active ingredients on the systems involved in the pathophysiology of anxiety...
January 15, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29332005/impact-of-a-negative-emotional-antitobacco-mass-media-campaign-on-french-smokers-a-longitudinal-study
#9
Romain Guignard, Karine Gallopel-Morvan, Ute Mons, Karin Hummel, Viêt Nguyen-Thanh
BACKGROUND: Mass media campaigns to encourage smoking cessation have been shown to be effective in a context of comprehensive tobacco control programme. The effectiveness of antismoking ads that evoke negative emotions remains unclear, in particular in countries with high smoking prevalence and among smokers with low perceived susceptibility, low self-efficacy or who are not users of smoking cessation services. OBJECTIVE: To evaluate short-term and long-term effects of a 1-month French national highly emotional media campaign, with a focus on these specific targets...
January 13, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29331976/concealment-of-type-1-diabetes-at-work-in-finland-a-mixed-method-study
#10
Pirjo Hakkarainen, Fehmidah Munir, Leena Moilanen, Kimmo Räsänen, Vilma Hänninen
OBJECTIVES: To explore the possible reasons for concealing type 1 diabetes (T1D) at work. METHODS: The main set of data came from a cross-sectional survey (response rate 49.3%), the participants of which were 688 wage earners with T1D. Concealment of T1D was measured by asking respondents have they ever during their working career hidden their diabetes from their (A) colleagues and (B) line manager. Furthermore, semistructured interviews (n=20) were conducted to obtain deeper understanding...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331871/rupture-during-coiling-of-intracranial-aneurysms-predictors-and-clinical-outcome
#11
Damian Kocur, Nikodem Przybyłko, Piotr Bażowski, Jan Baron
INTRODUCTION: The intraprocedural aneurysm rupture (IPR) is one of the most feared adverse effect associated with the coil embolization therapy. The aim of the study was to identify predisposing factors for IPR, as well as to define patient groups with worse clinical outcome following IPR. PATIENTS AND METHODS: From February 2008 to March 2015, 273 consecutive patients were treated at our institution via endovascular coil embolization. Patient medical records were reviewed with emphasis on procedure description, potential risk factors and clinical outcomes related to IPR...
January 8, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29331727/individual-variation-in-working-memory-is-associated-with-fear-extinction-performance
#12
Daniel M Stout, Dean T Acheson, Tyler M Moore, Ruben C Gur, Dewleen G Baker, Mark A Geyer, Victoria B Risbrough
PTSD has been associated consistently with abnormalities in fear acquisition and extinction learning and retention. Fear acquisition refers to learning to discriminate between threat and safety cues. Extinction learning reflects the formation of a new inhibitory-memory that competes with a previously learned threat-related memory. Adjudicating the competition between threat memory and the new inhibitory memory during extinction may rely, in part, on cognitive processes such as working memory (WM). Despite significant shared neural circuits and signaling pathways the relationship between WM, fear acquisition, and extinction is poorly understood...
January 5, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29331697/longitudinal-trajectories-of-post-traumatic-stress-disorder-ptsd-after-birth-and-associated-risk-factors
#13
Pelin Dikmen-Yildiz, Susan Ayers, Louise Phillips
BACKGROUND: Although longitudinal trajectories of post-traumatic stress disorder (PTSD) are well-established in general trauma populations, very little is known about the trajectories of birth-related PTSD. This study aimed to identify trajectories of birth-related PTSD; determine factors associated with each trajectory; and identify women more likely to develop birth-related PTSD. METHOD: 226 women who had traumatic childbirth according to DSM-IV criterion A were drawn from a community sample of 950 women...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331657/views-of-teenage-children-about-the-effects-of-a-parent-s-mobility-disability
#14
Lisa I Iezzoni, Amy J Wint, Alexy Arauz Boudreau, Cheri A Blauwet, Karen A Kuhlthau
BACKGROUND: Few U.S. studies have explored how children experience a parent's mobility disability and its effects on their daily lives. OBJECTIVE: We aimed to engage youth ages 13-17 who had at least one parent with mobility disability in describing their perceptions of their parent's disability and its consequences for their daily and family life. METHODS: Participants videoed and photographed their experiences following general guidelines from the researchers about topics of interest...
December 29, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29331353/mechanisms-of-sex-differences-in-fear-and-posttraumatic-stress-disorder
#15
REVIEW
Teniel Sonya Ramikie, Kerry James Ressler
Following sexual maturity, females disproportionately have higher rates of posttraumatic stress disorder (PTSD) and experience greater symptom severity and chronicity as compared with males. This observation has led many to examine sex differences in PTSD risk factors. Though relatively few, these studies reveal that the root causes of PTSD sex differences are complex, and partly represent interactions between sex-specific nonbiological and biological risk factors, which differentially shape PTSD vulnerability...
November 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29331102/opposite-sex-relationship-questionnaire-for-female-adolescents-development-and-psychometric-evolution
#16
Masoumeh Sibmar, Nasim Bahrami, AbouAli Vedadhir, Hamid Alavi Majd, Averil Parker
Aim The goal of the present study is to adopt state-of-the-art techniques and standards to develop and evaluate a measure, called the opposite-sex relationship questionnaire for female adolescents (OSRQFA), to assess the reasons why adolescent girls would or would not develop, a relationship with an adolescent boy. Methods A mixed-method, sequential, exploratory design was adopted. In the qualitative phase, an in-depth interview approach was used to identify the properties and dimensions to be included in the OSRQFA...
January 13, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29330699/accounting-of-ghg-emissions-and-removals-from-forest-management-a-long-road-from-kyoto-to-paris
#17
REVIEW
Joachim H A Krug
BACKGROUND: Forests have always played an important role in agreeing on accounting rules during the past two decades of international climate policy development. Starting from activity-based gross-net accounting of selected forestry activities to mandatory accounting against a baseline-rules have changed quite rapidly and with significant consequences for accounted credits and debits. Such changes have direct consequences on incentives for climate-investments in forestry. There have also been strong arguments not to include forests into the accounting system by considering large uncertainties, procedural challenges and a fear of unearned credits corrupting the overall accounting system, among others...
January 3, 2018: Carbon Balance and Management
https://www.readbyqxmd.com/read/29330232/interventions-must-be-realistic-to-be-useful-and-completed-in-family-medicine
#18
EDITORIAL
Marjorie A Bowman, Dean A Seehusen, Anne Victoria Neale
Being realistic while helping our patients is this issue's theme. Given the volume of tasks required in family medicine, recommendations for improvements in direct care or care measurement cannot just be evidence-based but must also be realistic. On the list of realistic: ordering antipsychotics for symptoms of dementia in the elderly, despite recommendations to not do so; ordering antidepressants without fear that the patient could develop hypertension; mental health care providers in primary care offices; forced choice for opioid management; plus agenda setting for visit efficiency...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330097/learning-situated-emotions
#19
Lauren A M Lebois, Christine D Wilson-Mendenhall, W Kyle Simmons, Lisa Feldman Barrett, Lawrence W Barsalou
From the perspective of constructivist theories, emotion results from learning assemblies of relevant perceptual, cognitive, interoceptive, and motor processes in specific situations. Across emotional experiences over time, learned assemblies of processes accumulate in memory that later underlie emotional experiences in similar situations. A neuroimaging experiment guided participants to experience (and thus learn) situated forms of emotion, and then assessed whether participants tended to experience situated forms of the emotion later...
January 9, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29330073/the-association-of-clinic-based-mobility-tasks-and-measures-of-community-performance-and-risk
#20
M L Callisaya, J Verghese
INTRODUCTION: Gait speed is recognized as an important predictor of adverse outcomes in older people. However, it is unknown if other more complex mobility tasks are better predictors of such outcomes. OBJECTIVE: To examine a range of clinic-based mobility tests and determine which were most strongly associated with measures of community performance and risk (CP&R). DESIGN: Cross-sectional study SETTING: Central Control Mobility and Aging Study, Westchester County, New York PARTICIPANTS: Aged ≥ 65 years (n=424) METHODS: Clinic-based mobility measures included gait speed measured during normal and dual-task conditions, the Floor Maze Immediate and Delay tasks, and stair ascending and descending...
January 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
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