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https://www.readbyqxmd.com/read/28526827/activated-hepatic-stellate-cells-secrete-periostin-to-induce-stem-cell-like-phenotype-of-residual-hepatocellular-carcinoma-cells-after-heat-treatment
#1
Rui Zhang, Rong-Rong Yao, Jing-Huan Li, Gang Dong, Min Ma, Qiong-Dan Zheng, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen
Some evidences show that residual tumor after thermal ablation will progress rapidly. However, its mechanisms remain unclear. Here, we assessed whether activated HSCs could regulate stem cell-like property of residual tumor after incomplete thermal ablation to promote tumor progression. Human HCC cell lines were exposed to sublethal heat treatment to simulate the peripheral zone of thermal ablation. After residual HCC cells were cultured with conditional medium (CM) from activated HSCs, parameters of the stem cell-like phenotypes were analyzed...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28520819/in-vitro-analysis-of-the-segmental-flexibility-of-the-thoracic-spine
#2
Hans-Joachim Wilke, Andrea Herkommer, Karin Werner, Christian Liebsch
Basic knowledge about the thoracic spinal flexibility is limited and to the authors' knowledge, no in vitro studies have examined the flexibility of every thoracic spinal segment under standardized experimental conditions using pure moments. In our in vitro study, 68 human thoracic functional spinal units including the costovertebral joints (at least n = 6 functional spinal units per segment from T1-T2 to T11-T12) were loaded with pure moments of ±7.5 Nm in flexion/extension, lateral bending, and axial rotation in a custom-built spine tester to analyze range of motion (ROM) and neutral zone (NZ)...
2017: PloS One
https://www.readbyqxmd.com/read/28518064/an-experimental-and-finite-element-protocol-to-investigate-the-transport-of-neutral-and-charged-solutes-across-articular-cartilage
#3
Vahid Arbabi, Behdad Pouran, Amir A Zadpoor, Harrie Weinans
Osteoarthritis (OA) is a debilitating disease that is associated with degeneration of articular cartilage and subchondral bone. Degeneration of articular cartilage impairs its load-bearing function substantially as it experiences tremendous chemical degradation, i.e. proteoglycan loss and collagen fibril disruption. One promising way to investigate chemical damage mechanisms during OA is to expose the cartilage specimens to an external solute and monitor the diffusion of the molecules. The degree of cartilage damage (i...
April 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28507345/genetic-variation-and-phylogeographic-structure-of-the-cotton-aphid-aphis-gossypii-based-on-mitochondrial-dna-and-microsatellite-markers
#4
Xing-Ya Wang, Xian-Ming Yang, Bin Lu, Li-Hong Zhou, Kong-Ming Wu
Aphis gossypii, one of the most important agricultural pests in the world, can cause serious economic losses in the main crop-producing areas. To clarify issues such as the genetic differentiation, genetic structure, and demographic history of A. gossypii populations, we used 10 nuclear microsatellite loci (SSR) and two mitochondrial gene sequences (COI and Cytb) to investigate genetic diversity and population structure of A. gossypii populations that were collected from 33 sampling sites in China from different climatic zones...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506254/reemergence-of-yellow-fever-in-ethiopia-after-50%C3%A2-years-2013-epidemiological-and-entomological-investigations
#5
Abrham Lilay, Negga Asamene, Abyot Bekele, Mesfin Mengesha, Milliyon Wendabeku, Israel Tareke, Abiy Girmay, Yonas Wuletaw, Abate Adossa, Yamar Ba, Amadou Sall, Daddi Jima, Debritu Mengesha
BACKGROUND: Yellow Fever (YF) is a viral hemorrhagic disease transmitted by aedes mosquito species. Approximately, 200,000 cases and 30,000 deaths occur worldwide every year. In Ethiopia, the last outbreak was reported in 1966 with 2200 cases and 450 deaths. A number of cases with deaths from unknown febrile illness reported from South Ari district starting from November 2012. This investigation was conducted to identify the causative agent, source of the outbreak and recommend appropriate interventions...
May 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28500972/fate-and-transport-of-hexahydro-1-3-5-trinitro-1-3-5-triazine-rdx-and-its-degradation-products-in-sedimentary-and-volcanic-rocks-los-alamos-new-mexico
#6
Brent Porter Heerspink, Sachin Pandey, Hakim Boukhalfa, Doug S Ware, Oana Marina, George Perkins, Velimir V Vesselinov, Giday WoldeGabriel
High-explosive compounds including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) were used extensively in weapons research and testing at Los Alamos National Laboratory (LANL). Liquid effluents containing RDX were released to an outfall pond that flowed to Cañon de Valle at LANL's Technical Area 16 (TA-16), resulting in the contamination of the alluvial, intermediate and regional groundwater bodies. Monitoring of groundwater within Cañon de Valle has shown persistent RDX in the intermediate perched zone located between 225 and 311 m below ground surface...
May 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28497813/warming-the-mouse-to-model-human-diseases
#7
REVIEW
Kirthana Ganeshan, Ajay Chawla
Humans prefer to live within their thermal comfort or neutral zone, which they create by making shelters, wearing clothing and, more recently, by regulating their ambient temperature. These strategies enable humans to maintain a constant core temperature (a trait that is conserved across all endotherms, including mammals and birds) with minimal energy expenditure. Although this primordial drive leads us to seek thermal comfort, we house our experimental animals, laboratory mice (Mus musculus), under conditions of thermal stress...
May 12, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28462018/glacial-allopatry-vs-postglacial-parapatry-and-peripatry-the-case-of-hedgehogs
#8
Barbora Černa Bolfíková, Kristýna Eliášová, Miroslava Loudová, Boris Kryštufek, Petros Lymberakis, Attila D Sándor, Pavel Hulva
Although hedgehogs are well-known examples of postglacial recolonisation, the specific processes that shape their population structures have not been examined by detailed sampling and fast-evolving genetic markers in combination with model based clustering methods. This study aims to analyse the impacts of isolation within glacial refugia and of postglacial expansion on the population structure of the Northern White-breasted hedgehog (Erinaceus roumanicus). It also discusses the role of the processes at edges of species distribution in its evolutionary history...
2017: PeerJ
https://www.readbyqxmd.com/read/28461883/comparison-of-antimicrobial-effects-of-titanium-tetrafluoride-chlorhexidine-xylitol-and-sodium-fluoride-on-streptococcus-mutans-an-in-vitro-study
#9
Tahereh Eskandarian, Mohammad Motamedifar, Peyman Arasteh, Seyed Sajad Eghbali, Ali Adib, Zahra Abdoli
INTRODUCTION: No studies have yet documented the bactericidal effects of TiF4, and its role in the treatment of dental caries, and no definite protocol has been introduced to regulate its use. The aim of this study was to determine the antimicrobial/bactericidal effects of TiF4 on Streptococcus Mutans (S. Mutans) and to compare it with chlorhexidine (Chx), sodium fluoride (NaF) and xylitol. METHODS: This study was conducted at the Shiraz University of Medical Sciences microbiology laboratory during March 2015 to September 2015...
March 2017: Electronic Physician
https://www.readbyqxmd.com/read/28438316/multiple-modes-of-capillary-electrophoresis-applied-in-peptide-nucleic-acid-related-study
#10
Xiaoqian Wang, Youhao Hu, Feng Qu, Rizwan Ullah Khan
Peptide Nucleic Acid (PNA) is a nucleic acid analogue, whose neutrally charged and hydrophobic backbone makes it more stable in vivo, so it might act as a potentially better protein probe as compared to aptamer. Currently the investigation of PNA and protein interaction is scarce. In this research, multiple modes of capillary electrophoresis were established and applied for PNA characterization and its interaction with ssDNA and protein. A 15-mer PNA having the same nucleobase sequence as 15-mer anti-thrombin DNA aptamer was chosen as PNA model for this study, its pI (7...
April 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28437577/high-gene-flow-despite-opposite-chirality-in-hybrid-zones-between-enantiomorphic-door-snails
#11
Eva L Koch, Marco T Neiber, Frank Walther, Bernhard Hausdorf
We studied differentiation and gene flow patterns between enantiomorphic door-snail species in two hybrid zones in the Bucegi Mountains (Romania) to investigate the effects of intrinsic barriers (complications in copulation) and extrinsic selection by environmental factors. A mitochondrial gene tree confirmed the historical separation of the examined populations into the dextral Alopia livida and the sinistral Alopia straminicollis in accordance with the morphological classification, but also indicated gene flow between the species...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28428868/metapopulation-patterns-of-additive-and-nonadditive-genetic-variance-in-the-sea-bass-dicentrarchus-labrax
#12
Bruno Guinand, Marc Vandeputte, Mathilde Dupont-Nivet, Alain Vergnet, Pierrick Haffray, Hervé Chavanne, Béatrice Chatain
Describing and explaining the geographic within-species variation in phenotypes ("phenogeography") in the sea over a species distribution range is central to our understanding of a variety of eco-evolutionary topics. However, phenogeographic studies that have a large potential to investigate adaptive variation are overcome by phylogeographic studies, still mainly focusing on neutral markers. How genotypic and phenotypic data could covary over large geographic scales remains poorly understood in marine species...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28428842/incipient-ecological-speciation-between-successional-varieties-of-a-dominant-tree-involves-intrinsic-postzygotic-isolating-barriers
#13
Elizabeth A Stacy, Bhama Paritosh, Melissa A Johnson, Donald K Price
Whereas disruptive selection imposed by heterogeneous environments can lead to the evolution of extrinsic isolating barriers between diverging populations, the evolution of intrinsic postzygotic barriers through divergent selection is less certain. Long-lived species such as trees may be especially slow to evolve intrinsic isolating barriers. We examined postpollination reproductive isolating barriers below the species boundary, in an ephemeral hybrid zone between two successional varieties of the landscape-dominant Hawaiian tree, Metrosideros polymorpha, on volcanically active Hawai'i Island...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28424594/overexpression-of-human-sod1-leads-to-discrete-defects-in-the-cerebellar-architecture-in-the-mouse
#14
Pegah Afshar, Niloufar Ashtari, Xiaodan Jiao, Maryam Rahimi-Balaei, Xiaosha Zhang, Behzad Yaganeh, Marc R Del Bigio, Jiming Kong, Hassan Marzban
The human superoxide dismutase 1 (SOD1) gene is responsible for neutralizing supercharged oxygen radicals within the cell. Mutation in SOD1 gene causes amyotrophic lateral sclerosis (ALS). Recent studies have shown involvement of the cerebellum in ALS, although the cerebellar contribution in SOD1 transgenic mice remains unclear. Using immunohistopathology, we investigated the Purkinje cell phenotype in the vermis of the SOD1 transgenic mice cerebellum. Calbindin 1 (Calb1) and three well-known zone and stripe markers, zebrin II, HSP25, and PLCβ4 have been used to explore possible alteration in zone and stripe...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28418580/effect-of-surfactant-species-and-electrophoretic-medium-composition-on-the-electrophoretic-behavior-of-neutral-and-water-insoluble-linear-synthetic-polymers-in-nonaqueous-capillary-zone-electrophoresis
#15
Nao Fukai, Shinya Kitagawa, Hajime Ohtani
We have recently demonstrated the separation of neutral and water-insoluble linear synthetic polymers in nonaqueous capillary zone electrophoresis (NACZE) using a cationic surfactant of cetyltrimethylammonium chloride (CTAC). In this study, eight ionic surfactants were investigated for the separation of four synthetic polymers (polystyrene, polymethylmethacrylates, polybutadiene, and polycarbonate); only three surfactants (CTAC, dimethyldioctadecylammonium bromide, and sodium dodecylsulfate) caused their separation...
April 18, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28402181/chemical-composition-of-rosehips-from-different-rosa-species-an-alternative-source-of-antioxidants-for-food-industry
#16
Sandra Jiménez, Nerea Jiménez-Moreno, Asunción Luquin, Mariano Laguna, María Jesús Rodríguez-Yoldi, Carmen Ancín-Azpilicueta
It is important to explore new sources of natural additives because the demand for these compounds by consumers is increasing. These products also provide health benefits and help in food preservation. An unexplored source of nutrients and antioxidant compounds is rosehip, the fleshy fruit of roses. This work compares antioxidant compounds (vitamin C, neutral phenols and acidic phenols) content of four Rosa species rosehips: R. pouzinii, R. corymbifera, R. glauca and R. canina coming from different geographical zones...
April 12, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28379939/re-evaluation-of-learned-information-in-drosophila
#17
Johannes Felsenberg, Oliver Barnstedt, Paola Cognigni, Suewei Lin, Scott Waddell
Animals constantly assess the reliability of learned information to optimize their behaviour. On retrieval, consolidated long-term memory can be neutralized by extinction if the learned prediction was inaccurate. Alternatively, retrieved memory can be maintained, following a period of reconsolidation during which it is labile. Although extinction and reconsolidation provide opportunities to alleviate problematic human memories, we lack a detailed mechanistic understanding of memory updating. Here we identify neural operations underpinning the re-evaluation of memory in Drosophila...
April 13, 2017: Nature
https://www.readbyqxmd.com/read/28344495/enantioselective-analysis-of-fluoxetine-in-pharmaceutical-formulations-by-capillary-zone-electrophoresis
#18
Melania Cârcu-Dobrin, Monica Budău, Gabriel Hancu, Laszlo Gagyi, Aura Rusu, Hajnal Kelemen
Fluoxetine is an antidepressant, a selective serotonin reuptake inhibitor (SSRI) used primarily in the treatment of major depression, panic disorder and obsessive compulsive disorder. Chiral separation of racemic fluoxetine is necessary due to its enantioselective metabolism. In order to develop a suitable method for chiral separation of fluoxetine, cyclodextrin (CD) modified capillary electrophoresis (CE) was employed. A large number of native and derivatized, neutral and ionized CD derivatives were screened to find the optimal chiral selector...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28343575/expression-analysis-of-toll-like-receptors-and-interleukins-in-tharparkar-cattle-during-acclimation-to-heat-stress-exposure
#19
Jaya Bharati, S S Dangi, S R Mishra, V S Chouhan, V Verma, O Shankar, M K Bharti, A Paul, Dilip K Mahato, G Rajesh, G Singh, V P Maurya, S Bag, Puneet Kumar, M Sarkar
Six male Tharparkar cattle of 2-3 years old were selected for the study. After 15 days acclimation at thermo neutral zone (TNZ) in psychrometric chamber, animals were exposed at 42°C for 6h up to 23 days followed by 12 days of recovery period. Blood samples were collected during control period at TNZ (day 1, 5 and 12), after heat stress exposure (day 1-10, Short Term Heat Stress Acclimation - STHSA; day 15-23, Long Term Heat Stress Acclimation - LTHSA) and recovery period (day 7 and 12) and peripheral blood mononuclear cells (PBMCs) were isolated for RNA and protein extraction...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28314568/health-workers-and-the-weaponisation-of-health-care-in-syria-a-preliminary-inquiry-for-the-lancet-american-university-of-beirut-commission-on-syria
#20
Fouad M Fouad, Annie Sparrow, Ahmad Tarakji, Mohamad Alameddine, Fadi El-Jardali, Adam P Coutts, Nour El Arnaout, Lama Bou Karroum, Mohammed Jawad, Sophie Roborgh, Aula Abbara, Fadi Alhalabi, Ibrahim AlMasri, Samer Jabbour
The conflict in Syria presents new and unprecedented challenges that undermine the principles and practice of medical neutrality in armed conflict. With direct and repeated targeting of health workers, health facilities, and ambulances, Syria has become the most dangerous place on earth for health-care providers. The weaponisation of health care-a strategy of using people's need for health care as a weapon against them by violently depriving them of it-has translated into hundreds of health workers killed, hundreds more incarcerated or tortured, and hundreds of health facilities deliberately and systematically attacked...
March 14, 2017: Lancet
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