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https://www.readbyqxmd.com/read/28240653/paraspinal-muscle-passive-stiffness-remodels-in-direct-response-to-spine-stiffness-a-study-using-the-ent1-deficient-mouse
#1
Kelsey Y Gsell, Derek P Zwambag, Dale E Fournier, Cheryle A Séguin, Stephen H M Brown
STUDY DESIGN: Basic science study of the relationship between the structural properties of the spine and its surrounding musculature. OBJECTIVE: To determine if an increase in spine stiffness causes an inverse compensatory change in the passive stiffness of the adjacent paraspinal muscles. SUMMARY OF BACKGROUND DATA: Intervertebral disc degeneration causes an increase in multifidus passive stiffness; this was hypothesized to compensate for a decrease in spine stiffness associated with disc degeneration...
February 24, 2017: Spine
https://www.readbyqxmd.com/read/28222180/pre-existing-neutralizing-antibody-mitigates-b-cell-dysregulation-and-enhances-the-env-specific-antibody-response-in-shiv-infected-rhesus-macaques
#2
Juan Pablo Jaworski, Peter Bryk, Zachary Brower, Bo Zheng, Ann J Hessell, Alexander F Rosenberg, Tong Tong Wu, Ignacio Sanz, Michael C Keefer, Nancy L Haigwood, James J Kobie
Our central hypothesis is that protection against HIV infection will be powerfully influenced by the magnitude and quality of the B cell response. Although sterilizing immunity, mediated by pre-formed abundant and potent antibodies is the ultimate goal for B cell-targeted HIV vaccine strategies, scenarios that fall short of this may still confer beneficial defenses against viremia and disease progression. We evaluated the impact of sub-sterilizing pre-existing neutralizing antibody on the B cell response to SHIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28214974/interaction-of-scots-pine-defensin-with-model-membrane-by-coarse-grained-molecular-dynamics
#3
Elena Ermakova, Yuriy Zuev
Plant defensins are a part of the innate immune system of plants that acts against a broad range of pathogens. Many plant defensins, including pine defensins, show strong antifungal activity that is associated with their ability to penetrate into the fungal cell membrane. However, the exact molecular mechanism of their action remains poorly defined. To obtain insight into the mechanism of protein-membrane interaction, we applied a coarse-grained molecular dynamics simulation to study the interaction of pine defensin with two model membranes: the first consisted of zwitterion-neutral POPC molecules and the second was composed of combined anionic POPG and POPC...
February 18, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28207656/biomechanical-evaluation-of-transpedicular-nucleotomy-with-intact-annulus-fibrosus
#4
Fabrizio Russo, Robert A Hartman, Kevin M Bell, Nam Vo, Gwendolyn A Sowa, James D Kang, Gianluca Vadalà, Vincenzo Denaro
STUDY DESIGN: Biomechanical testing of partially nucleotomized ovine cadaveric spines. OBJECTIVE: To explore how the nucleus pulposus (NP) affects the biomechanical behavior of the intervertebral disc (IVD) by performing a partial nucleotomy via the transpedicular approach. SUMMARY OF BACKGROUND DATA: Mechanical loading represents a crucial part of IVD homeostasis. However, traditional regenerative strategies require violation of the annulus fibrosus (AF) resulting in significant alteration of joint mechanics...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28190488/effect-of-a-titanium-cage-as-a-stand-alone-device-on-biomechanical-stability-in-the-lumbosacral-spine-of-canine-cadavers
#5
M Teunissen, A J van der Veen, T H Smit, M A Tryfonidou, B P Meij
Degenerative lumbosacral stenosis is a common disease in dogs characterised by intervertebral disc herniation, loss of disc height and stenosis. Decompressive dorsal laminectomy and partial discectomy can cause spinal instability and worsen foraminal stenosis. Pedicle screw and rod fixation (PSRF) with an intervertebral body cage allows for distraction and restoration of disc height and restores foraminal apertures. The aim of this study was to evaluate the ex vivo biomechanical properties of a titanium intervertebral cage alone and in combination with PSRF in the lumbosacral spine of dogs...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28187232/evaluating-the-performance-of-thermal-sensation-prediction-with-a-biophysical-model
#6
M Schweiker, Brm Kingma, A Wagner
Neutral thermal sensation is expected for a human body in heat balance in near steady-state thermal environments. The physiological thermoneutral zone (TNZ) is defined as the range of operative temperatures where the body can maintain such heat balance by actively adjusting body tissue insulation, but without regulatory increases in metabolic rate or sweating. These basic principles led to the hypothesis that thermal sensation relates to the operative temperature distance from the thermoneutral centroid (dTNZop )...
February 10, 2017: Indoor Air
https://www.readbyqxmd.com/read/28184227/using-ceres-maize-and-enso-as-decision-support-tools-to-evaluate-climate-sensitive-farm-management-practices-for-maize-production-in-the-northern-regions-of-ghana
#7
Dilys S MacCarthy, Samuel G K Adiku, Bright S Freduah, Francis Gbefo, Alpha Y Kamara
Maize (Zea mays) has traditionally been a major cereal staple in southern Ghana. Through breeding and other crop improvement efforts, the zone of cultivation of maize has now extended to the northern regions of Ghana which, hitherto, were the home to sorghum and millet as the major cereals. Maize yield in the northern Ghana is hampered by three major biophysical constraints, namely, poor soil fertility, low soil water storage capacity and climate variability. In this study we used the DSSAT crop model to assess integrated water and soil management strategies that combined the pre-season El-Niño-Southern Oscillation (ENSO)-based weather forecasting in selecting optimal planting time, at four locations in the northern regions of Ghana...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28165217/calcium-assists-dopamine-release-by-preventing-aggregation-on-the-inner-leaflet-of-presynaptic-vesicles
#8
Sini Mokkila, Pekka A Postila, Sami Rissanen, Hanna Juhola, Ilpo Vattulainen, Tomasz Rog
Tightly controlled neurotransmitter-membrane interactions can speed up signal transduction by coordinating the movements of the transmitters inside the synapse. In this study, the dopamine-lipid bilayer interactions were probed with three physiologically relevant ion compositions using atomistic molecular dynamics simulations and free energy calculations. The in silico results show that calcium decreases significantly the binding of dopamine to a neutral (zwitterionic) phosphatidylcholine lipid bilayer used to model the inner leaflet of a presynaptic vesicle...
February 6, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28161046/is-surface-water-acidification-a-serious-regional-issue-in-china
#9
Qian Yu, Ting Zhang, Zhenglin Cheng, Bin Zhao, Jan Mulder, Thorjørn Larssen, Shuxiao Wang, Lei Duan
Acidic deposition used to cause severe surface water acidification in Europe and the North America, but no damage of surface water acidification was reported under continuous heavy acid deposition in China. We present the first detailed study on regional surface water acidification in southern and northeastern China based on a survey of 255 forested headwater streams, which were investigated during 2010-2015 to explore the status and mechanism of surface water acidification. South China has a subtropical climate with high acid deposition, whereas northeast China is located in a cold temperature zone with relatively low acid deposition...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28159341/cameo-surface-recording-in-complete-denture-fabrication-using-transcutaneous-electrical-nerve-stimulation-a-clinical-report
#10
Dheeraj Koli, Aditi Nanda, Harsimran Kaur, Mahesh Verma, Chandan Jain
Severe bone loss in patients with complete edentulism poses a treatment challenge. In fabricating a denture, the stability of the prosthesis must be enhanced by recording the cameo surface within the confines of the physiological position of the cheek and tongue muscles (the neutral zone) and by shaping it accordingly. The treatment of a patient with a completely edentulous maxillary arch and severe maxillary anterior bone loss is described. The cameo surface was recorded within the physiological limits during the fabrication of a complete denture by using transcutaneous electrical nerve stimulation (TENS)...
January 31, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28157621/analysis-of-the-upper-cervical-spine-stiffness-during-axial-rotation-a-comparative-study-among-patients-with-tension-type-headache-or-migraine-and-asymptomatic-subjects
#11
P-M Dugailly, A Decuyper, W Salem, A De Boe, G V Espí-López, Y Lepers
BACKGROUND: Many studies reported the implication of the cervical musculoskeletal system in patients with tension type headache and migraine. The objective of this study is to investigate the upper cervical spine stiffness features in axial rotation among headache patients in comparison with a healthy population. METHODS: 48 subjects including 30 migraine patients with/without aura and 18 patients with tension-type headache, aged between 18 and 60years (mean 36, SD 11years) have been evaluated...
January 27, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28148644/characteristics-of-the-local-cutaneous-sensory-thermo-neutral-zone
#12
Davide Filingeri, Hui Zhang, Edward A Arens
Skin temperature detection thresholds have been used to measure human cold and warm sensitivity across the temperature continuum. They exhibit a sensory zone within which neither warm nor cold sensations prevail. This zone has been widely assumed to coincide with steady-state local skin temperatures between 32-34ᵒC, but its underlying neurophysiology has been rarely investigated. Here we employ two approaches to characterize the properties of sensory thermo-neutrality, testing for each whether neutrality shifts along the temperature continuum depending on adaptation to a preceding thermal state...
February 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28122401/customized-cheek-plumper-with-friction-lock-attachment-for-a-completely-edentulous-patient-to-enhance-esthetics-a-clinical-report
#13
Prem Bhushan, Meena A Aras, Ivy Coutinho, Praveen Rajagopal, Ashwin R Mysore, Swati Kumar
Prosthetic rehabilitation of a completely edentulous patient should never be restricted to the replacement of missing teeth. The ultimate aim of complete denture treatment should be restoration of the full range of oral functions and esthetics. Slumped cheeks are always a concern for esthetically demanding complete denture patients. This article describes a simple, scientific, cost-effective technique to improve facial esthetics in a completely edentulous patient with the help of a cheek plumper. The technique used here implements the concept of neutral zone to precisely determine the amount of space available for the cheek plumper...
January 25, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28117815/capillary-electrophoresis-separation-of-monoclonal-antibody-isoforms-using-a-neutral-capillary
#14
Carlos Eduardo Espinosa-de la Garza, Rodolfo Daniel Salazar-Flores, Néstor Octavio Pérez, Luis Francisco Flores-Ortiz, Emilio Medina-Rivero
Biotherapeutic proteins, such as monoclonal antibodies (mAbs), are feasible alternatives for the treatment of chronic-degenerative diseases. The biological activity of these proteins depends on their physicochemical properties. The use of high-performance techniques like chromatography and capillary electrophoresis has been described for the analysis of physicochemical heterogeneity of mAbs. Nowadays, capillary zone electrophoresis (CZE) technique constitutes one of the most resolutive and sensitive assays for the analysis of biomolecules...
January 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28107235/an-experimental-biomechanical-study-on-artificial-atlantoodontoid-joint-replacement-in-dogs
#15
Quanjin Zang, Yanming Liu, Dengfeng Wang, Haopeng Li, Pinglin Yang, Dong Wang, Xijing He
STUDY DESIGN: This study tested the biomechanics of artificial atlantoodontoid joint replacement (AAOJR) in a dog model. Dogs were divided into the artificial AAOJR group (n=10), the decompression group (n=10), and the healthy control group (n=10) using a random number table. OBJECTIVE: To evaluate whether the use of AAOJR for repair of atlantoaxial instability retains rotation and restores stability. SUMMARY OF BACKGROUND DATA: Atlantoaxial instability is characterized by excessive movement or laxity at the junction between the atlas (C1) and axis (C2)...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28102312/correlations-of-charge-neutrality-level-with-electronic-structure-and-p-d-hybridization
#16
Arkaprava Das, Subodh K Gautam, D K Shukla, Fouran Singh
The formation of charge neutrality level (CNL) in highly conducting Cadmium oxide (CdO) thin films is demonstarted by the observed variation in the band gap upon annealing and doping. It may be explained by the observation that Tin (Sn) doping breaks the perfect periodicity of CdO cubic crystal structure and creates virtual gap states (ViGS). The level of local CNL resides at the branch point of ViGS, making the energy at which native defect's character changes from predominantly donor-like below CNL to predominantly acceptor-like above the CNL and a schematic band diagram is developed to substantiate the same...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097503/blended-chitosan-paste-for-infection-prevention-preliminary-and-preclinical-evaluations
#17
Joel M Berretta, Jessica A Jennings, Harry S Courtney, Karen E Beenken, Mark S Smeltzer, Warren O Haggard
BACKGROUND: Local drug delivery devices offer a promising method for delivering vancomycin and amikacin for musculoskeletal wounds. However, current local delivery devices such as beads and sponges do not necessarily allow for full coverage of a wound surface with eluted antibiotics and do not address the need for reducing the antibiotic diffusion distance to help prevent contamination by bacteria or other microorganisms. We blended chitosan/polyethylene glycol (PEG) pastes/sponges to increase biocompatibility and improve antibiotic coverage within the wound...
January 17, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28065928/unveiling-the-osmophores-of-philodendron-adamantinum-araceae-as-a-means-to-understanding-interactions-with-pollinators
#18
Patrícia Gonçalves-Souza, Clemens Schlindwein, Stefan Dötterl, Elder Antônio Sousa Paiva
BACKGROUND AND AIMS: Araceae species pollinated by nocturnal Cyclocephalini beetles attract their pollinators by inflorescence scents. In Philodendron, despite the intense odour, the osmophores exhibit no definite morphological identity, making them difficult to locate. This may explain why structural studies of the scent-releasing tissue are not available so far. METHODS: Several approaches were employed for locating and understanding the osmophores of Philodendron adamantinum A sensory test allowed other analyses to be restricted to fertile and sterile stamens as odour production sites...
January 8, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28059097/fibrous-hamartoma-of-infancy-a-clinicopathologic-study-of-145-cases-including-2-with-sarcomatous-features
#19
Alyaa Al-Ibraheemi, Anthony Martinez, Sharon W Weiss, Harry P Kozakewich, Antonio R Perez-Atayde, Henry Tran, David M Parham, William R Sukov, Karen J Fritchie, Andrew L Folpe
Fibrous hamartoma of infancy is a rare soft tissue lesion of infants and young children with characteristic triphasic morphology, which typically occurs in the axilla and less commonly in other locations. We reviewed 145 cases of fibrous hamartoma of infancy from our consultation archives. Cases occurred in 106 males and 39 females (mean age-15 months; range-birth to 14 years), and involved both typical sites (eg, axilla/back/upper arm) (n=69) and unusual locations (n=76). Six were congenital. The tumors presented as subcutaneous masses and ranged from 0...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28044210/cobalt-complexes-as-internal-standards-for-capillary-zone-electrophoresis-mass-spectrometry-studies-in-biological-inorganic-chemistry
#20
Hannah U Holtkamp, Stuart J Morrow, Mario Kubanik, Christian G Hartinger
Run-by-run variations are very common in capillary electrophoretic (CE) separations and cause imprecision in both the migration times and the peak areas. This makes peak and kinetic trend identification difficult and error prone. With the aim to identify suitable standards for CE separations which are compatible with the common detectors UV, ESI-MS, and ICP-MS, the Co(III) complexes [Co(en)3]Cl3, [Co(acac)3] and K[Co(EDTA)] were evaluated as internal standards in the reaction of the anticancer drug cisplatin and guanosine 5'-monophosphate as an example of a classical biological inorganic chemistry experiment...
January 2, 2017: Journal of Biological Inorganic Chemistry: JBIC
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