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fetal viability gestational age

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https://www.readbyqxmd.com/read/28271174/advanced-paternal-age-and-stillbirth-rate-a-nationwide-register-based-cohort-study-of-944-031-pregnancies-in-denmark
#1
Stine Kjaer Urhoj, Per Kragh Andersen, Laust Hvas Mortensen, George Davey Smith, Anne-Marie Nybo Andersen
Advanced paternal age has been associated with a variety of rare conditions and diseases of great public health impact. An increased number of de novo point mutations in sperm with increasing age have been suggested as a mechanism, which would likely also affect fetal viability. We examined the association between paternal age and stillbirth rate in a large nationwide cohort. We identified all pregnancies in Denmark from 1994 to 2010 carried to a gestational age of at least 22 completed weeks (n = 944,031) as registered in national registers and linked to individual register data about the parents...
March 7, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28258975/animatio-a-history-of-ideas-on-the-beginning-of-personhood
#2
Michael Obladen
The onset of individual human life has fascinated thinkers of all cultures and epochs, and the history of their ideas may enlighten an unsettled debate. Aristotle attributed three different souls to the subsequent developmental stages. The last, the rational soul, was associated with the formed fetus, and entailed fetal movements. With some modifications, the concept of delayed ensoulment - at 30, 42, 60, or 90 days after conception - was adopted by several Christian Church Fathers and remained valid throughout the Middle Ages...
March 4, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28193233/tacrolimus-in-the-prevention-of-adverse-pregnancy-outcomes-and-diabetes-associated-embryopathies-in-obese-and-diabetic-mice
#3
Ahmad J H Albaghdadi, Melanie A Hewitt, Samantha M Putos, Michael Wells, Terence R S Ozolinš, Frederick W K Kan
BACKGROUND: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscarriages and fetal malformations. Despite the established association between placental insufficiency and poor maternal Th1-adaptability to the development of pregnancy complications in T2DM, there have been no established data to assess benefits of pre-pregnancy immunosuppression relative to gestational outcomes in T2DM. We hypothesized that pre-pregnancy macrolide immune suppression can re-establish normal placental development and uterine vascular adaptation in a mouse model of obesity-associated T2DM...
February 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28101838/renal-consequences-of-preterm-birth
#4
REVIEW
Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch, Abhay Lodha
BACKGROUND: The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viability in premature infants have been pushed to lower gestational ages, the long-term impact of prematurity on kidneys still remains a significant burden during hospital stay and beyond. OBJECTIVES: The purpose of this study is to summarize available evidence, mechanisms, and short- and long-term renal consequences of prematurity and identify nephroprotective strategies and areas of uncertainty...
December 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/27814911/population-based-outcomes-data-for-counseling-at-the-margin-of-gestational-viability
#5
Patrick Myers, Naomi Laventhal, Bree Andrews, Joanne Lagatta, William Meadow
OBJECTIVE: To survey neonatologists as to how many use population-based outcomes data to counsel families before and after the birth of 22- to 25-week preterm infants. STUDY DESIGN: An anonymous online survey was distributed to 1022 neonatologists in the US. Questions addressed the use of population-based outcome data in prenatal and postnatal counseling. RESULTS: Ninety-one percent of neonatologists reported using population-based outcomes data for counseling...
February 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27744430/impact-of-fetal-weight-estimation-on-the-prediction-of-neonatal-morbidity-and-mortality-at-the-limit-of-viability
#6
Jarmila A Zdanowicz, Chantal Huber, Roland Gerull, Martin Mueller, Luigi Raio, Daniel Surbek
INTRODUCTION: To determine the accuracy of estimated fetal weight (EFW) at the limit of viability in a delivery room setting and its impact on the prediction of neonatal outcome. MATERIAL AND METHODS: In this retrospective, single-center cohort study we included patients with preterm birth between 230/7 and 260/7 weeks of gestation. Neonates were divided into 3 groups according to birth weight at delivery (accuracy index 90-110%, <90%, >110%). Neonatal outcome for each group was categorized into survival with and without impairment and death, with a follow-up period of 6 weeks...
2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27614267/terminating-pregnancy-for-severe-hypertension-when-the-fetus-is-considered-non-viable-a-retrospective-cohort-study
#7
Leonoor Van Eerden, Miriam F Van Oostwaard, Gerda G Zeeman, Godelieve C M Page-Christiaens, Eva Pajkrt, Johannes J Duvekot, Frank P Vandenbussche, Swan G Oei, Hubertina C J Scheepers, Jim Van Eyck, Johanna M Middeldorp, Steven V Koenen, Christianne J M De Groot, Antoinette C Bolte
OBJECTIVE: To investigate frequency and practise of termination of pregnancy for early-onset hypertensive disorders where the fetus is considered to be non-viable. STUDY DESIGN: Retrospective cohort study in all Dutch tertiary perinatal care centres (n=10), between January 2000 and January 2014. All women who underwent termination of pregnancy, without fetal surveillance or intention to intervene for fetal reasons, for early-onset hypertensive disorders in pregnancy, were analyzed...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27565260/longitudinal-changes-in-maternal-serum-concentrations-of-antim%C3%A3-llerian-hormone-in-individual-women-during-conception-cycles-and-early-pregnancy
#8
COMPARATIVE STUDY
Kristina Hamilton, Narelle Hadlow, Peter Roberts, Patricia Sykes, Allison McClements, Jacqui Coombes, Phillip Matson
OBJECTIVE: To study antimüllerian hormone (AMH) from gestation week 0-7. DESIGN: Longitudinal study of 85 pregnant women with AMH and reproductive hormones sampled during conception cycle and early pregnancy until week 7. SETTING: Fertility clinic. PATIENT(S): Of 85 pregnant women, 69 had a singleton pregnancy, 1 a twin pregnancy, and 15 had a nonviable pregnancy (3 chemical pregnancies, 11 miscarriages, and 1 blighted ovum)...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27555144/prone-position-craniotomy-in-pregnancy-without-fetal-heart-rate-monitoring
#9
Jean Jacob, Ashish Alexander, Shoba Philip, Anoop Thomas
A pregnant patient in second trimester scheduled for posterior fossa craniotomy in prone position is a challenge for the anesthesiologist. Things to consider are physiological changes during pregnancy, non-obstetric surgery in pregnant patients, neuroanesthetic principles, effects of prone positioning, and need for fetal heart rate (FHR) monitoring. We have described the anesthetic management of this case and discussed intra-operative FHR monitoring including controversies about its role, indications, and various options available as per fetal gestational age...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27509872/can-maternal-fetal-hemodynamics-influence-prenatal-development-in-dogs
#10
Luana Azevedo de Freitas, Gustavo Lobato Mota, Herlon Victor Rodrigues Silva, Cibele Figueira Carvalho, Lúcia Daniel Machado da Silva
The goals of this study were to report embryonic and fetal ultrasound changes and compare blood flow of uteroplacental and umbilical arteries of normal and abnormal conceptus. Accordingly, from the day of mating or artificial insemination, all fetuses in 60 pregnancies were evaluated weekly. According to the ultrasound findings, the gestational age was determined and the conceptuses were divided into normal or abnormal (embryonic and fetal abnormalities). The two-dimensional ultrasound assessment consists of measuring and evaluating the echogenicity of conceptus and extra-fetal structures...
September 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27214190/obstetric-care-consensus-no-4-periviable-birth
#11
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
June 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27214184/obstetric-care-consensus-no-4-summary-periviable-birth
#12
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
June 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27154158/extracorporeal-membrane-oxygenation-for-cardiopulmonary-failure-during-pregnancy-and%C3%A2-postpartum
#13
Cara Agerstrand, Darryl Abrams, Mauer Biscotti, Leslie Moroz, Erika B Rosenzweig, Mary D'Alton, Daniel Brodie, Matthew Bacchetta
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has been used with increasing frequency to support pregnant and postpartum patients with severe cardiac or pulmonary failure, although patient management and clinical outcomes are underreported. This study represents patients who received ECMO during the peripartum period. METHODS: All pregnant or postpartum patients treated with ECMO in the medical intensive care unit between January 1, 2009, and June 30, 2015, were included in this study...
September 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27103153/periviable-birth-interim-update
#14
Jeffrey L Ecker, Anjali Kaimal, Brian M Mercer, Sean C Blackwell, Raye Ann O deRegnier, Ruth M Farrell, William A Grobman, Jamie L Resnik, Anthony C Sciscione
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
August 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26815911/expression-and-functional-roles-of-estrogen-receptor-gpr30-in-human-intervertebral-disc
#15
Aiqun Wei, Bojiang Shen, Lisa A Williams, Divya Bhargav, Feng Yan, Beng H Chong, Ashish D Diwan
Estrogen withdrawal, a characteristic of female aging, is associated with age-related intervertebral disc (IVD) degeneration. The function of estrogen is mediated by two classic nuclear receptors, estrogen receptor (ER)-α and -β, and a membrane bound G-protein-coupled receptor 30 (GPR30). To date, the expression and function of GPR30 in human spine is poorly understood. This study aimed to evaluate GPR30 expression in IVD, and its role in estrogen-related regulation of proliferation and apoptosis of disc nucleus pulposus (NP) cells...
April 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26721776/racial-disparity-in-previable-birth
#16
Emily A DeFranco, Eric S Hall, Louis J Muglia
BACKGROUND: Extremely preterm birth of a live newborn before the limit of viability is rare but contributes uniformly to the infant mortality rate because essentially all cases result in neonatal death. OBJECTIVE: The objective of the study was to quantify racial differences in previable birth and their contribution to infant mortality and to estimate the relative influence of factors associated with live birth occurring before the threshold of viability. STUDY DESIGN: This was a population-based retrospective cohort of all live births in Ohio over a 7 year period, 2006-2012...
March 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26692771/relationship-between-uterine-natural-killer-cells-and-unexplained-repeated-miscarriage
#17
Mohamed M Farghali, Abdel-Latif G El-Kholy, Khaled H Swidan, Ibrahim A Abdelazim, Ahmed R Rashed, Ezzat El-Sobky, Mostafa F Goma
OBJECTIVE: To evaluate the relation between uterine killer (uK) cells and unexplained repeated miscarriage (RM). MATERIAL AND METHODS: Eighty women with unexplained repeated miscarriage and missed miscarriage of current pregnancy were studied. Fetal viability and gestational age of the current pregnancy were confirmed by ultrasound, followed by suction evacuation to collect abortion specimens and uterine wall curettage to collect decidua specimens. Abortion specimens were collected for long-term monolayer cell culture and subsequent chromosome analysis using conventional G-banding...
2015: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/26663220/role-of-serum-biomarkers-in-the-prediction-of-outcome-in-women-with-threatened-miscarriage-a-systematic-review-and-diagnostic-accuracy-meta-analysis
#18
REVIEW
Rekha N Pillai, Justin C Konje, Douglas G Tincello, Neelam Potdar
BACKGROUND: Threatened miscarriage affects one in five women and is associated with significant emotional distress. The uncertainty around the prognosis of threatened miscarriage makes it equally challenging to the healthcare professionals. Various biochemical markers have been investigated in the past to predict the outcome of threatened miscarriage; however, the results have been conflicting. Therefore, we have conducted a systematic review and meta-analysis to determine the diagnostic accuracy of biochemical markers in predicting the outcome in women presenting with threatened miscarriage...
March 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/26620625/a-pilot-study-of-women-s-experiences-after-being-offered-late-termination-of-pregnancy-for-severe-fetal-anomaly
#19
L Govender, C Ndjapa-Ndamkou, C Aldous, J Moodley
OBJECTIVE: We investigated the attitudes and experiences of women pregnant with an anomalous fetus after being offered late termination of pregnancy (LTOP) before and after delivery or TOP. METHODS: This was a pre- and post-intervention structured interview questionnaire-based study. Pregnant women with severe fetal abnormalities (lethal and nonlethal) diagnosed after 24 weeks gestation were recruited. All were managed according to standard protocol. Interviews were conducted by the researcher over a 3 months period (August-October 2010)...
December 2015: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/26506448/-3-periviable-birth
#20
Jeffrey L Ecker, Anjali Kaimal, Brian M Mercer, Sean C Blackwell, Raye Ann O deRegnier, Ruth M Farrell, William A Grobman, Jamie L Resnik, Anthony C Sciscione
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
November 2015: American Journal of Obstetrics and Gynecology
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