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https://www.readbyqxmd.com/read/29451437/do-intraoperative-radiographs-predict-final-lumbar-sagittal-alignment-following-single-level-transforaminal-lumbar-interbody-fusion
#1
Khalid M I Salem, Aditya P Eranki, Scott Paquette, Michael Boyd, John Street, Brian K Kwon, Charles G Fisher, Marcel F Dvorak
OBJECTIVE The study aimed to determine if the intraoperative segmental lordosis (as calculated on a cross-table lateral radiograph following a single-level transforaminal lumbar interbody fusion [TLIF] for degenerative spondylolisthesis/low-grade isthmic spondylolisthesis) is maintained at discharge and at 6 months postsurgery. METHODS The authors reviewed images and medical records of patients ≥ 16 years of age with a diagnosis of an isolated single-level, low-grade spondylolisthesis (degenerative or isthmic) with symptomatic spinal stenosis treated between January 2008 and April 2014...
February 16, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29436831/on-the-formation-of-c-2v-c-72-11188-cl-4-a-particularly-stable-non-ipr-fullerene
#2
Antonio Moreno-Vicente, Laura Abella, Khalid Azmani, Antonio Rodríguez-Fortea, Josep M Poblet
Halogenation has been one of the most used strategies to explore the reactivity of empty carbon cages. In particular, the higher reactivity of non-IPR fullerenes, i.e. those fullerenes that do not satisfy the Isolated Pentagon Rule (IPR), has been used to functionalize and capture these less stable fullerenes. Here, we have explored the stability and reactivity of the non-IPR isomer C72(11188) with C2v symmetry, which is topologically linked to the only IPR isomer of C70. DFT calculations and Car-Parrinello molecular dynamics simulations suggest that chlorination takes places initially in non-specific sites, once carbon cages are formed...
February 13, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29436217/a-stealth-and-fully-laden-drug-carrier-self-assembled-nanogel-encapsulated-with-epigallocatechin-gallate-and-sirna-for-drug-resistant-breast-cancer-therapy
#3
Jie Ding, Tingxizi Liang, Qianhao Min, Li-Ping Jiang, Jun-Jie Zhu
For co-delivery of therapeutic genes and chemical agents in combined therapy, the ideal drug delivery system (DDS) entails high-capacity and low-body toxicity carriers, allowing adequate drug dose for tumor region while yielding low residue in normal tissue. To augment the gene/drug load capacity and circumvent the potential toxicity brought by traditional inorganic and polymeric nanocarriers, a "stealth" carrier was herein designed in a simple self-assembly of (-)-epigallocatechin-3-O-gallate (EGCG) and small interfering RNA (siRNA) by recruiting protamine as biodegradable medium for the treatment of drug-resistant triple-negative breast cancer (TNBC)...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29433530/correlation-between-lumbar-intervertebral-disc-height-and-lumbar-spine-sagittal-alignment-among-asymptomatic-asian-young-adults
#4
Feng Zhang, Kai Zhang, Hai-Jun Tian, Ai-Min Wu, Xiao-Fei Cheng, Tang-Jun Zhou, Jie Zhao
BACKGROUND: To investigate the distribution and characteristics of the lumbar intervertebral disc height (IDH) in asymptomatic Asian population and to determine whether the lumbar IDH is related to the lumbar spine sagittal alignment. METHODS: A cohort of 169 cases of asymptomatic volunteers was enrolled from January 2014 to July 2016. All participants underwent magnetic resonance imaging of the lumbar spine and panoramic radiography of the spine. Panoramic radiographs of the spine were taken to evaluate pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT) using Surgimap® software...
February 12, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29433006/strains-in-trussed-spine-interbody-fusion-implants-are-modulated-by-load-and-design
#5
Jason P Caffrey, Eloy Alonso, Koichi Masuda, Jessee P Hunt, Cameron N Carmody, Timothy M Ganey, Robert L Sah
Titanium cages with 3-D printed trussed open-space architectures may provide an opportunity to deliver targeted mechanical behavior in spine interbody fusion devices. The ability to control mechanical strain, at levels known to stimulate an osteogenic response, to the fusion site could lead to development of optimized therapeutic implants that improve clinical outcomes. In this study, cages of varying design (1.00 mm or 0.75 mm diameter struts) were mechanically characterized and compared for multiple compressive load magnitudes in order to determine what impact certain design variables had on localized strain...
February 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29430605/analysis-of-single-cage-position-in-transforaminal-lumbar-interbody-fusion-through-digital-images
#6
Xin Zhao, Chen Chen, Tangjun Zhou, Jie Mi, Lin Du, Zhanrong Kang, Jianming Huang, Kai Zhang, Xiaojiang Sun, Jie Zhao
PURPOSE: The purpose of this study was to investigate the position of single cage inserted using oblique-oriented technique in transforaminal lumbar interbody fusion (TLIF) on digital images of computed tomography (CT). METHODS: From January to August 2015, 44 consecutive patients with degenerative lumbar disease who underwent TLIF in the L4/5 level were retrospectively studied in our department. The single cage was inserted using the oblique-oriented technique; as the main purpose of the study, its position was analyzed using post-operative digital computed tomography images...
February 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29427761/status-of-helicobacter-pylori-cag-pathogenicity-island-cagpai-integrity-and-significance-of-its-individual-genes
#7
Rumyana Markovska, Lyudmila Boyanova, Daniel Yordanov, Petya Stankova, Galina Gergova, Ivan Mitov
One of the most important virulence factors of H. pylori is the intact cagPAI. The aim of the present study is to investigate cagPAI intactness among Bulgarian H. pylori isolates, its associations with clinical outcomes and vacA alleles, and to evaluate the significance of individual cagPAI genes. MATERIAL AND METHODS: Totally, 156 isolates from 156 patients with endoscopic findings for duodenal or gastric ulcer (33 subjects), non-ulcer disease (121) and other diseases, such as Crohn's disease and hepatitis (2) were tested...
February 7, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29417772/-case-control-study-on-two-different-surgical-approaches-combined-fixation-with-lumbar-interbody-fusion-for-the-treatment-of-single-segmental-lumbar-vertebra-diseases
#8
Zhong-You Zeng, Wei-Feng Yan, Yong-Xing Song, Ke-Ya Mao, Jian-Fei Ji, Jian-Qiao Zhang, Peng Wu, Fei Pei, Guo-Hao Song, Jian-Fu Han, Wei Yu
OBJECTIVE: To discuss the advantages and disadvantages of two different surgical approaches combined fixation with lumbar interbody fusion in treating single segmental lumbar vertebra diseases. METHODS: The clinical data of 86 patients with single segmental lumbar vertebra diseases treated from June 2011 to June 2013 was retrospectively analyzed. There were 33 males and 53 females, aged from 28 to 76 years old with an average of 53.0 years. Among them, there were 39 cases of lumbar disc degeneration, 22 cases of lumbar disc herniation complicated with spinal canal stenosis, 9 cases of huge lumbar disc herniation and 16 cases of lumbar degenerative spondylolisthesis (Meyerding degree I )...
May 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29417323/georg-schmorl-prize-of-the-german-spine-society-dwg-2017-correction-of-spino-pelvic-alignment-with-relordosing-mono-and-bisegmental-tlif-spondylodesis
#9
Frederick Galla, Dirk Wähnert, Ulf Liljenqvist
INTRODUCTION: A balanced ratio of the main parameters of lumbar lordosis (LL) and pelvic incidence (PI) has high clinical relevance. A postoperative mismatch of LL and PI has been described in the literature to be associated with an inferior clinical outcome and higher postoperative revision rates. The aim of this retrospective, radiological study is to evaluate the magnitude of relordosing in mono-/bisegmental TLIF spondylodesis affecting the spino-pelvic alignment and the main contributing factors...
February 7, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29416588/correlation-of-clinical-and-radiological-outcome-after-anterior-cervical-discectomy-and-fusion-with-a-polyetheretherketone-cage
#10
Savvas L Spanos, Ioannis D Siasios, Vassilios G Dimopoulos, Konstantinos N Paterakis, Dimos S Mastrogiannis, Theofanis P Giannis, Aggeliki A Fotiadou, John Pollina, Kostas N Fountas
Background: Anterior cervical discectomy and fusion (ACDF) with a polyetheretherketone (PEEK) cage is considered as the gold standard for patients with cervical disc disease. However, there are limited in vivo data on the impact of ACDF on the cervical kinematics and its association with patient-reported clinical outcomes. The purpose of this study was to investigate the impact of altered cervical sagittal alignment (cervical lordosis) and sagittal range of motion (ROM) on patients' self-reported pain and functional disability, after ACDF with a PEEK cage...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29410587/correlation-between-diaphragm-thickness-and-respiratory-synergist-muscle-activity-according-to-severity-of-chronic-obstructive-pulmonary-disease
#11
Jeong-Il Kang, Dae-Keun Jeong, Hyun Choi
[Purpose] This study aims to analyze the effect that moderate to severe chronic obstructive pulmonary disease (COPD) has on the respiratory synergist muscles. The results will provide basic data that can be used in the clinical management of COPD. [Subjects and Methods] The subjects in the study were 47 male patients with COPD between 55 and 70 years old who were treated in a medical institution located in Jeollanam-do Province, South Korea, from October 2015 to December 2016. Measurements were analyzed to determine the correlation between the diaphragm thickness and the respiratory synergist muscle activity in patients with mild COPD...
January 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29408015/endocrine-regulation-of-migratory-departure-from-stopover-evidence-from-a-longitudinal-migratory-restlessness-study-on-northern-wheatears
#12
Cas Eikenaar, Florian Müller, Georg Rüppel, Mareike Stöwe
Most migrating birds make stopovers to replenish fuel stores. The decision to resume migration from stopover to a large extent shapes the temporal organization of migration. This decision is known to be shaped by a suite of intrinsic and extrinsic factors such as the bird's fuel stores and current weather conditions. However, how departures from stopover are physiologically regulated is largely unknown. We here present data that strongly indicate that corticosterone, a hormone with a stimulatory effect on locomotion, acts as a mediator between fuel stores and departure from stopover...
February 2, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29406698/modular-bioorthogonal-strategy-for-the-controlled-loading-of-car-go-into-a-protein-nanocage
#13
Lise Schoonen, Selma Eising, Mark B van Eldijk, Jaleesa Bresseleers, Margo van der Pijl, Roeland J M Nolte, Kimberly M Bonger, Jan C M van Hest
Virus capsids, i.e. viruses devoid of their genetic material, are suitable nanocarriers for biomedical applica-tions such as drug delivery and diagnostic imaging. For this purpose, the reliable encapsulation of cargo in such a protein nanocage is crucial, which can be accomplished by the covalent attachment of the com-pounds of interest to the protein domains positioned at the interior of the cage. This approach is particularly valid for the capsid proteins of the cowpea chlorotic mottle virus (CCMV), which have their N-termini located at the inside of the capsid structure...
February 6, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29403246/surgical-management-of-c-type-subaxial-cervical-fractures-using-cervical-traction-followed-by-anterior-cervical-discectomy-and-fusion-within-12-h-after-the-trauma
#14
Pasquale Donnarumma, Vincenzo Bozzini, Gaetano Rizzi, Arturo Berardi, Gaetano Merlicco
Study Design: This was a retrospective cohort study. Objective: To report our 10-year experience of closed reduction using Crutchfield traction followed by anterior cervical discectomy and fusion within 12 h from injury for C-type subaxial cervical fractures (according to the AOSpine classification system). Methods: Clinical records and neuroimaging were retrospectively reviewed. Surgical details were provided. Results: A total of 22 patients were included in the study...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29398621/myosin-vi-dependent-actin-cages-encapsulate-parkin-positive-damaged-mitochondria
#15
Antonina J Kruppa, Chieko Kishi-Itakura, Thomas A Masters, Joanna E Rorbach, Guinevere L Grice, John Kendrick-Jones, James A Nathan, Michal Minczuk, Folma Buss
Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated mitophagy. Here, we demonstrate that MYO6 (myosin VI), a unique myosin that moves toward the minus end of actin filaments, forms a complex with Parkin and is selectively recruited to damaged mitochondria via its ubiquitin-binding domain. This myosin motor initiates the assembly of F-actin cages to encapsulate damaged mitochondria by forming a physical barrier that prevents refusion with neighboring populations...
January 31, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29385098/synthesis-and-biological-evaluations-of-no-donating-oxa-and-aza-pentacycloundecane-derivatives-as-potential-neuroprotective-candidates
#16
Rajan Sharma, Jacques Joubert, Sarel F Malan
In order to utilize the neuroprotective properties of polycyclic cage compounds, and explore the NO-donating ability of nitrophenyl groups, an array of compounds was synthesized where the different nitrophenyl groups were appended on oxa and aza-bridged cage derivatives. Biological evaluations of the compounds were done for cytotoxicity, neuroprotective abilities, the inhibition of N-methyl-d-aspartate (NMDA)-mediated Ca2+ influx, the inhibition of voltage-mediated Ca2+ influx, and S-nitrosylation abilities...
January 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29376368/topology-based-approach-to-predict-relative-stabilities-of-charged-and-functionalized-fullerenes
#17
Yang Wang, Sergio Díaz-Tendero, Manuel Alcami, Fernando Martin
Understanding the relationship between structure and stability is one of the fundamental aspects of fullerene chemistry, as the number of possible cage isomers is very large and complexity increases by orders of magnitude when chemical groups are attached to the fullerene cage. The well-established stability rules valid for neutral fullerenes do not apply to many charged or functionalized fullerenes. Here we present the theory, implementation and applications of two simple topology-based models that allow one to predict the relative stability of charged and functionalized fullerenes without the need for quantum chemistry calculations: (i) the charge stabilization index (CSI) model, based on the concepts of cage connectivity and frontier π orbitals, which offers a general framework for the relative stability of both positively and negatively charged fullerenes, as well as endohedral metallofullerenes, and (ii) the exohedral fullerene stabilization index (XSI) model, which incorporates all key factors governing the stability of exohedral fullerenes, namely, π delocalization, σ strain and steric hindrance between addends...
January 27, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29376360/steering-the-geometry-of-butterfly-shaped-dimetal-carbide-cluster-within-a-carbon-cage-via-trifluoromethylation-of-y2c2-c82-6
#18
Fei Jin, Nadezhda B Tamm, Sergey I Troyanov, Shangfeng Yang
As one of the largest sub-branches of endohedral clusterfullerenes, dimetal carbide clusterfullerene (CCF) in the form of M2C2@C2n is quite intriguing since an alternative structure of M2@C2n+2 as conventional dimetallofullerene may exist as well. Herein, by using high-temperature trifluoromethylation followed by HPLC separation and single-crystal X-ray diffraction study, we report for the first time the unambiguous structural determination of yttrium (Y)-based CCF as its trifluoromethyl derivatives, Y2C2@C82(6)(CF3)16...
January 28, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29356386/significance-of-tumor-associated-autoantibodies-in-the-early-diagnosis-of-lung-cancer
#19
Qiang Du, Ruofei Yu, Han Wang, Dong Yan, Qi Yuan, Yixin Ma, Dennis Slamon, Dongmei Hou, Huiling Wang, Qi Wang
OBJECTIVES: Autoantibodies tumor-associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer due to their relatively high specificity and stability. The purpose of this study is to detect the level of tumor-associated autoantibodies in lung cancer and assess the diagnostic potential of autoantibodies in screening strategy for early stage lung cancer. MATERIALS AND METHODS: Levels of tumor-associated autoantibodies (AAbs) were measured against a panel of seven tumor-associated antigens (p53, PGP9...
January 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29354758/gibbus-deformity-after-non-tuberculosis-osteomyelitis
#20
Akop Seksenyan, Darian R Esfahani, Kimberly Hu, Ankit I Mehta
Gibbus deformities are characterized by anterior collapse of one or more vertebral bodies resulting in kyphosis. These deformities usually arise from spinal infections, and are traditionally associated with tuberculosis; other pathogens are rarely reported in the literature. In this case report, the authors describe a patient with a sharp, angulated Gibbus deformity presenting with back pain and myelopathy. The patient was placed on antibiotics, underwent T11-T12 corpectomy, placement of an expandable cage, and T8-L3 fusion with improvement of symptoms...
December 2017: Journal of Spine Surgery (Hong Kong)
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