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https://www.readbyqxmd.com/read/28525492/degenerative-cervical-disc-disease-long-term-changes-in-sagittal-alignment-and-their-clinical-implications-after-cervical-interbody-fusion-cage-subsidence-a-prospective-study-with-standalone-lordotic-tantalum-cages
#1
Félix Tomé-Bermejo, Julián A Morales-Valencia, Javier Moreno-Pérez, Juan Marfil-Pérez, Elena Díaz-Dominguez, Angel R Piñera, Luis Alvarez
STUDY DESIGN: A retrospective, observational study of prospectively collected outcomes. OBJECTIVE: To investigate the long-term clinical course of anterior cervical discectomy and fusion with interbody fusion cages (ACDF-IFC) with lordotic tantalum implants and to correlate the radiologic findings with the clinical outcomes, with special emphasis on the significance and the influence of implant subsidence. SUMMARY OF BACKGROUND DATA: Cage subsidence is the most frequently reported complication after ACDF-IFC...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28508699/antimicrobial-anticancer-and-antioxidant-compounds-from-premna-resinosa-growing-in-saudi-arabia
#2
Dina A Albadawi, Ramzi A Mothana, Jamal M Khaled, Abdelkhader E Ashour, Ashok Kumar, Sheikh F Ahmad, Mansour S Al-Said, Adnan J Al-Rehaily, Nawal M Almusayeib
CONTEXT: Premna resinosa (Hochst.) Schauer (Lamiaceae) is used in many places to treat bronchitis, respiratory illness and convulsions of the rib cage. OBJECTIVE: This study evaluates the anticancer, antimicrobial and antioxidant activities of P. resinosa, and isolates some responsible constituents. MATERIALS AND METHODS: The methanol extract of P. resinosa aerial parts and its fractions (n-hexane, dichloromethane, ethyl acetate and n-butanol) were tested...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28503368/running-wheel-training-does-not-change-neurogenesis-levels-or-alter-working-memory-tasks-in-adult-rats
#3
Cesar A Acevedo-Triana, Manuel J Rojas, Fernando Cardenas P
BACKGROUND: Exercise can change cellular structure and connectivity (neurogenesis or synaptogenesis), causing alterations in both behavior and working memory. The aim of this study was to evaluate the effect of exercise on working memory and hippocampal neurogenesis in adult male Wistar rats using a T-maze test. METHODS: An experimental design with two groups was developed: the experimental group (n = 12) was subject to a forced exercise program for five days, whereas the control group (n = 9) stayed in the home cage...
2017: PeerJ
https://www.readbyqxmd.com/read/28499016/minimally-invasive-transforaminal-lumbar-interbody-fusion-using-banana-shaped-and-straight-cages-radiological-and-clinical-results-from-a-prospective-randomized-clinical-trial
#4
Won-Suh Choi, Jin-Sung Kim, Jung-Woo Hur, Ji-Hoon Seong
BACKGROUND: In minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), cage type and position play important roles in fusion achievement and sagittal alignment correction. However, no prospective randomized comparison of the results using different types of cage has been reported to date. OBJECTIVE: To compare the radiological and clinical outcomes of unilateral MIS-TLIF using 2 types of cage. METHODS: All candidates for single-level MIS-TLIF were randomized into banana-shaped cage and straight-cage groups...
May 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28495376/gabaa-receptor-positive-allosteric-modulators-modify-the-abuse-related-behavioral-and-neurochemical-effects-of-methamphetamine-in-rhesus-monkeys
#5
Laís F Berro, Monica L Andersen, Sergio Tufik, Leonard L Howell
GABAA receptor positive allosteric modulators (GABAA receptor modulators) are commonly used for the treatment of insomnia. Nevertheless, the effects of these compounds on psychostimulant-induced sleep impairment are poorly understood. Because GABAA receptor modulators have been shown to decrease the abuse-related effects of psychostimulants, the aim of the present study was to evaluate the effects of temazepam (0.3, 1.0 or 3.0 mg/kg) and eszopiclone (0.3, 1.0 or 3.0 mg/kg), two GABAA receptor modulators, on the behavioral neuropharmacology of methamphetamine in adult rhesus macaques (n = 5)...
May 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28492957/screening-of-alcohol-use-disorders-in-psychiatric-outpatients-influence-of-gender-age-and-psychiatric-diagnosis
#6
Mónica Sánchez Autet, Marina Garriga, Francisco Javier Zamora, Idilio González, Judith Usall, Leticia Tolosa, Concepción Benítez, Raquel Puertas, Belén Arranz
Alcohol use disorders (AUD) are 2 times higher among psychiatric patients than in the general population. The under-recognition of this dual diagnosis can entail several negative outcomes. Early assessment with a screening tool like the CAGE questionnaire could be an opportunity to improve patients' prognoses. The objective of this study is to assess AUD risk in an outpatient psychiatric sample with a modified CAGE, considering the influence of age, gender and clinical psychiatric diagnosis. An observational, multicentric, descriptive study was carried out...
April 12, 2017: Adicciones
https://www.readbyqxmd.com/read/28488781/deciphering-the-effects-of-disperser-assemblages-and-seed-mass-on-patterns-of-seed-dispersal-in-a-rodent-community
#7
Aleksandra Wróbel, Rafał Zwolak
The sizes of both seed dispersers and seeds are traits that are likely to interact to influence seed fate in many synzoochoric plant species. Here, we examined whether members of a granivorous rodent community consisting of species of different body size vary in their effectiveness as seed dispersers, and how this relationship may be altered by seed size. We marked Northern red oak (Quercus rubra Linnaeus, 1753) acorns with plastic tags and placed them in size-selective rodent exclosures. The exclosures allowed differential access of rodent groups based on different body size: (1) small (e...
May 10, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/28481531/chemically-induced-breathing-of-flexible-porphyrinic-covalent-cages
#8
Laetitia Schoepff, Lucas Kocher, Stéphanie Durot, Valérie Heitz
The synthesis of two flexible bis-porphyrin cages 3 and 4, incorporating respectively Zn(II) porphyrins and free-base porphyrins is reported. In both cages, the four covalent linkers that bind the two porphyrins are functionalized with two 1,2,3-triazolyl ligands. These cages were characterized by NMR and HRMS and for cage 3 incorporating 1,4-diazabicyclo[2.2.2]octane (DABCO), an X-ray crystallographic structure was obtained. Chemically-induced conformational changes are studied and compared to the ones of two related cages with longer flexible linkers...
May 8, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28478774/supplementing-high-quality-fresh-forage-to-growing-lambs-fed-a-total-mixed-ration-diet-led-to-higher-intake-without-altering-nutrient-utilization
#9
A Pérez-Ruchel, J L Repetto, C Cajarville
The effect of supplementing high-quality fresh forage, mainly based on alfalfa, to growing lambs fed with decreasing levels of total mixed ration (TMR) was studied on intake, digestion and ruminal environment. In total, 24 catheterized lambs (25.2±3.67 kg) housed in individual metabolism cages were assigned to one of four treatment diets: 'TMR100': TMR offered ad libitum; 'TMR75' and 'TMR50': TMR at a level of 0.75 and 0.50 of potential intake, respectively, complemented with fresh forage without restriction; 'TMR0': only fresh forage ad libitum...
May 8, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28475020/anterior-cage-dislodgement-in-posterior-lumbar-interbody-fusion-a-review-of-12-patients
#10
Shuhei Murase, Yasushi Oshima, Yujiro Takeshita, Kota Miyoshi, Kazuhito Soma, Naohiro Kawamura, Junichi Kunogi, Takashi Yamazaki, Dai Ariyoshi, Shigeo Sano, Hirohiko Inanami, Katsushi Takeshita, Sakae Tanaka
OBJECTIVE Interbody fusion cages are widely used to achieve initial fixation and secure spinal fusion; however, there are certain technique-related complications. Although anterior cage dislodgement can cause major vascular injury, the incidence is extremely rare. Here, the authors performed a review of anterior cage dislodgement following posterior lumbar interbody fusion (PLIF) surgery. METHODS The authors retrospectively reviewed the cases of 4625 patients who had undergone PLIF at 6 institutions between December 2007 and March 2015...
May 5, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28472438/the-impact-of-chronic-sleep-restriction-on-neuronal-number-and-volumetric-correlates-of-the-dorsal-respiratory-nuclei-in-a-rat-model
#11
Ali-Mohammad Kamali, Fatemeh Karimi, Saied Karbalay-Doust, Mohammad Nami, Ali Noorafshan
Study Objectives: Sleep restriction can result in a range of neurophysiological consequences in the brain including some brain stem nuclei. This study aimed to evaluate the effects of chronic sleep restriction (CSR) on quantitative aspects of brain stem respiratory centers using stereological methods. Methods: Male rats were randomly assigned into experimental group (CSR through a modified multiple platform apparatus), corresponding apparatus-control group (grid-floor control) and cage controls...
May 2, 2017: Sleep
https://www.readbyqxmd.com/read/28465429/chlamydia-hijacks-arf-gtpases-to-coordinate-microtubule-posttranslational-modifications-and-golgi-complex-positioning
#12
Jordan Wesolowski, Mary M Weber, Agata Nawrotek, Cheryl A Dooley, Mike Calderon, Claudette M St Croix, Ted Hackstadt, Jacqueline Cherfils, Fabienne Paumet
The intracellular bacterium Chlamydia trachomatis develops in a parasitic compartment called the inclusion. Posttranslationally modified microtubules encase the inclusion, controlling the positioning of Golgi complex fragments around the inclusion. The molecular mechanisms by which Chlamydia coopts the host cytoskeleton and the Golgi complex to sustain its infectious compartment are unknown. Here, using a genetically modified Chlamydia strain, we discovered that both posttranslationally modified microtubules and Golgi complex positioning around the inclusion are controlled by the chlamydial inclusion protein CT813/CTL0184/InaC and host ARF GTPases...
May 2, 2017: MBio
https://www.readbyqxmd.com/read/28458532/relationship-between-lung-function-and-grip-strength-in-older-hospitalized-patients-a-pilot-study
#13
Sarah J Holmes, Stephen C Allen, Helen C Roberts
OBJECTIVE: Older people with reduced respiratory muscle strength may be misclassified as having COPD on the basis of spirometric results. We aimed to evaluate the relationship between lung function and grip strength in older hospitalized patients without known airways disease. METHODS: Patients in acute medical wards were recruited who were aged ≥70 years; no history, symptoms, or signs of respiratory disease; Mini Mental State Examination ≥24; willing and able to consent to participate; and able to perform hand grip and forced spirometry...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28451184/combatting-amr-photoactivatable-ruthenium-ii-isoniazid-complex-exhibits-rapid-selective-antimycobacterial-activity
#14
Nichola A Smith, Pingyu Zhang, Simon E Greenough, Michael D Horbury, Guy J Clarkson, Daniel McFeely, Abraha Habtemariam, Luca Salassa, Vasilios G Stavros, Christopher G Dowson, Peter J Sadler
The novel photoactive ruthenium(ii) complex cis-[Ru(bpy)2(INH)2][PF6]2 (1·2PF6, INH = isoniazid) was designed to incorporate the anti-tuberculosis drug, isoniazid, that could be released from the Ru(ii) cage by photoactivation with visible light. In aqueous solution, 1 rapidly released two equivalents of isoniazid and formed the photoproduct cis-[Ru(bpy)2(H2O)2](2+) upon irradiation with 465 nm blue light. We screened for activity against bacteria containing the three major classes of cell envelope: Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and Mycobacterium smegmatis in vitro using blue and multi-colored LED multi-well arrays...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28443289/frequency-and-duration-of-fecal-shedding-of-salmonella-enteritidis-by-experimentally-infected-laying-hens-housed-in-enriched-colony-cages-at-different-stocking-densities
#15
Richard K Gast, Rupa Guraya, Deana R Jones, Kenneth E Anderson, Darrin M Karcher
Human infections with Salmonella Enteritidis are often attributed to the consumption of contaminated eggs, so the prevalence of this pathogen in egg-laying poultry is an important public health risk factor. Numerous and complex environmental influences on Salmonella persistence and transmission are exerted by management practices and housing facilities used in commercial egg production. In recent years, the animal welfare implications of poultry housing systems have guided the development of alternatives to traditional cage-based housing, but their food safety consequences are not yet fully understood...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28438657/the-thiol-of-human-serum-albumin-acidity-microenvironment-and-mechanistic-insights-on-its-oxidation-to-sulfenic-acid
#16
Jenner Bonanata, Lucía Turell, Laura Antmann, Gerardo Ferrer-Sueta, Santiago Botasini, Eduardo Méndez, Beatriz Alvarez, E Laura Coitiño
Human serum albumin (HSA) has a single reduced cysteine residue, Cys34, whose acidity has been controversial. Three experimental approaches (pH-dependence of reactivity towards hydrogen peroxide, ultraviolet titration and infrared spectroscopy) are used to determine that the pKa value in delipidated HSA is 8.1 ± 0.2 at 37°C and 0.1M ionic strength. Molecular dynamics simulations of HSA in the sub-microsecond timescale show that while sulfur exposure to solvent is limited and fluctuating in the thiol form, it increases in the thiolate, stabilized by a persistent hydrogen-bond (HB) network involving Tyr84 and bridging waters to Asp38 and Gln33 backbone...
April 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28437978/tunable-optical-cage-array-generated-by-dammann-vector-beam
#17
Xiaoyu Weng, Luping Du, Peng Shi, Xiaocong Yuan
Optical cages attract considerable attentions recently owing to their potential applications in optical trapping, optical imaging and optical cloaking. However, the generation of tunable optical cage arrays in the transverse plane comes to a great challenge, which restricts the effectiveness of the above applications. In this work, we propose a full polarization-controlled method that optical cage arrays with tunable number and positions in the x-y plane can be generated by a so-called Dammann vector beam (DVB), both under the conditions of high- and low-NA focusing system...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437330/pedicle-screw-fluid-sign-an-indication-on-magnetic-resonance-imaging-of-a-deep-infection-after-posterior-spinal-instrumentation
#18
Hiroaki Kimura, Jitsuhiko Shikata, Seiichi Odate, Tsunemitsu Soeda
STUDY DESIGN: A single-center case-referent study. OBJECTIVE: To assess whether the "pedicle screw (PS) fluid sign" on magnetic resonance imaging (MRI) can be used to diagnose deep surgical site infection (SSI) after posterior spinal instrumentation (PSI). SUMMARY OF BACKGROUND DATA: MRI is a useful tool for the early diagnosis of a deep SSI. However, the diagnosis is frequently difficult with feverish patients with clear wounds after PSI because of artifacts from the metallic implants...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28433848/instrumented-circumferential-fusion-in-two-stages-for-instable-lumbar-fracture-long-term-results-of-a-series-of-74-patients-on-sagittal-balance-and-functional-outcomes
#19
Mourad Ould-Slimane, Camille Damade, Guillaume Lonjon, André Gilibert, Jérôme Cochereau, Rémi Gauthé, Nicolas Lonjon
AIM: To report the radiological and functional results of a multicentre, prospective case series of patients with comminuted lumbar fractures treated with two-stage circumferential arthrodesis. METHODS: A multicentre, prospective case series of 74 patients with comminuted lumbar fractures was analyzed. The strategy entailed initial posterior osteosynthesis then physical replacement with an expandable titanium cage filled with autologous bone, via retroperitoneal lumbotomy...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28431093/interactions-between-cassava-mosaic-geminiviruses-and-their-vector-bemisia-tabaci-hemiptera-aleyrodidae
#20
Simon B Boni, Costancia P Rugumamu, Dan Gerling, K Sagary Nokoe, James P Legg
The sweetpotato whitefly, Bemisia tabaci (Gennadius) is the vector of the cassava mosaic geminiviruses (CMGs) that cause cassava mosaic disease (CMD). Synergistic interactions between B. tabaci and CMGs have been hypothesized as a cause of whitefly "super-abundance," which has been a key factor behind the spread of the severe CMD pandemic through East and Central Africa. The current study investigated this hypothesis by conducting experiments with CMD-susceptible cassava varieties infected with different CMGs in both the north-western Lake Zone region (pandemic affected) and the eastern Coast Zone where CMD is less severe...
April 18, 2017: Journal of Economic Entomology
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