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https://www.readbyqxmd.com/read/29222874/a-homochiral-porous-organic-cage-with-large-cavity-and-pore-windows-for-the-efficient-gc-separation-of-enantiomers-and-positional-isomers
#1
Jun-Hui Zhang, Sheng-Ming Xie, Bang-Jin Wang, Pin-Gang He, Li-Ming Yuan
Porous organic cages composed of discrete cage molecules have attracted considerable recent attention as gas adsorption materials and separation media. In this study, we report a homochiral porous organic cage CC5 with a large cavity and pore windows as a novel stationary phase for high-resolution gas chromatographic separations. The capillary column was prepared by a static coating method. A large number of racemic compounds have been resolved on the coated capillary column, including derivatized amino acids, alcohols, alcohol amines, esters, ethers, ketones, and epoxides...
December 9, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29190825/spillover-of-the-atlantic-bluefin-tuna-offspring-from-cages-in-the-adriatic-sea-a-multidisciplinary-approach-and-assessment
#2
Tomislav Džoić, Gordana Beg Paklar, Branka Grbec, Stjepan Ivatek-Šahdan, Barbara Zorica, Tanja Šegvić-Bubić, Vanja Čikeš Keč, Ivana Lepen Pleić, Ivona Mladineo, Leon Grubišić, Philippe Verley
During routine monitoring of commercial purse seine catches in 2011, 87 fingerling specimens of scombrids were collected in the southern Adriatic Sea. Sequencing of the mitochondrial DNA control region locus inferred that specimens belonged to the Atlantic bluefin tuna, Thunnus thynnus (Linnaeus, 1758) (N = 29), bullet tuna, Auxis rochei (Risso, 1810) (N = 30) and little tunny, Euthynnus alletteratus, Rafinesque, 1810 (N = 28). According to previously published growth parameters, the age of the collected specimens was estimated at approximately 30-40 days, suggesting they might have been spawned in the Adriatic Sea, contrary to the current knowledge...
2017: PloS One
https://www.readbyqxmd.com/read/29186654/treatment-with-allogenic-mesenchymal-stromal-cells-in-a-murine-model-of-systemic-lupus-erythematosus
#3
Chiara Tani, Sabrina Vagnani, Linda Carli, Francesca Querci, Anja A Kühl, Simone Spieckermann, Constanze Pamela Cieluch, Simone Pacini, Rita Fazzi, Marta Mosca
Objective: Pre-clinical and uncontrolled studies in patients with systemic lupus erythematosus (SLE) showed that mesenchymal stromal cells (MSCs) have a potential therapeutic role in refractory cases. The optimal therapeutic strategy in these patients remain to be elucidated. Our aim was to test the hypothesis that repeated administrations of 1×106/kg body weight of allogenic MSCs, that is a significantly lower dosage with respect to the fixed 1×106 MSC used in animal models, can be effective in improving the clinical course of a murine SLE model...
November 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29185595/first-evidence-of-zika-virus-venereal-transmission-in-aedes-aegypti-mosquitoes
#4
Jordam William Pereira-Silva, Valdinete Alves do Nascimento, Heliana Christy Matos Belchior, Jéssica Feijó Almeida, Felipe Arley Costa Pessoa, Felipe Gomes Naveca, Claudia María Ríos-Velásquez
BACKGROUND: Aedes aegypti is considered the main Zika virus (ZIKV) vector, and is thought to be responsible for the 2015-2016 outbreak in Brazil. Zika positive Ae. aegypti males collected in the field suggest that vertical and/or venereal transmission of ZIKV may occur. OBJECTIVES: In this study, we aimed to demonstrate that venereal transmission of ZIKV by Ae. aegypti can occur under laboratory conditions. METHODS: Ae. aegypti collected in the city of Manaus, confirmed as negative for Zika, Dengue and Chikungunya virus by reverse transcription real-time polymerase chain reaction (RT-qPCR) (AaM3V- strain), were reared under laboratory conditions and used for the experiments...
November 27, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29172880/spiritual-struggles-and-problem-drinking-are-younger-adults-at-greater-risk-than-older-adults
#5
Neal Krause, Kenneth I Pargrament, Peter C Hill, Gail Ironson
BACKGROUND: Although a good deal of research has assessed the positive effects that involvement in religion has on alcohol use, there is relatively little research on the negative aspects of religious life and alcohol problems. OBJECTIVES: This study has two objectives. The first is to see if spiritual struggles are associated with problem drinking. The second is to see if the relationship between spiritual struggles and problem drinking is stronger for younger than for older adults...
November 27, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29166409/post-weaning-high-fat-diet-results-in-growth-cartilage-lesions-in-young-male-rats
#6
Samuel S Haysom, Mark H Vickers, Lennex H Yu, Clare M Reynolds, Elwyn C Firth, Sue R McGlashan
To determine if a high-fat diet (HF) from weaning would result in a pro-inflammatory state and affect joint cartilage, we fed male rats either HF or Chow diet post-weaning, and voluntary wheel exercise (EX) or cage only activity (SED) after 9 weeks of age. At 17 weeks body composition, plasma biomarkers and histomorphology scores of femoro-tibial cartilages of HF-SED, HF-EX, Chow-SED and Chow-EX groups were compared. Food intake and activity were not significantly different between groups. HF diet resulted in significantly higher weight gain, %fat, fat:lean ratio, and plasma leptin, insulin and TNFα concentrations, with significant interactions between diet and exercise...
2017: PloS One
https://www.readbyqxmd.com/read/29154844/anticoccidial-effects-of-areca-nut-areca-catechu-l-extract-on-broiler-chicks-experimentally-infected-with-eimeria-tenella
#7
Dingfa Wang, Luli Zhou, Wei Li, Hanlin Zhou, Guanyu Hou
To study the anticoccidial effects of areca nut extract (ANE) on coccidiosis, 270 one-day old Wenchang broiler chicks were divided into six equal groups, each with three replicate cages (n = 15 per cage). The six groups were the blank control group (BC), negative control group (NC), positive control group (PC), and three ANE-treated groups. The birds in the three control groups (BC, NC and PC) were fed a basal diet without ANE supplementation. The birds in the three ANE-treated groups were fed a basal diet supplied with ANE at 100 (T1), 200 (T2), or 300 (T3) mg/kg feed...
November 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29152448/vision-assisted-micromanipulation-using-closed-loop-actuation-of-multiple-microrobots
#8
M Arifur Rahman, Noboru Takahashi, Kawai F Siliga, Nigel K Ng, Zhidong Wang, Aaron T Ohta
Accurate control and precise positioning of opto-thermocapillary flow-addressed bubble microrobots are necessary for micromanipulation. In addition, micromanipulation using the simultaneous actuation of multiple microrobots requires a robust control system to enable independent motion. This paper demonstrates a hybrid closed-loop vision-assisted control system capable of actuating multiple microrobots simultaneously and positioning them at precise locations relative to micro-objects under manipulation. A vision-assisted grasp-planning application was developed and used to calculate the necessary trajectories of the microrobots to form cages around micro-objects...
2017: Robotics and Biomimetics
https://www.readbyqxmd.com/read/29142168/background-data-on-nod-shi-scid-il-2r%C3%AE-null-mice-nog-mice
#9
Kenichiro Kasahara, Yachiyo Fukunaga, Saori Igura, Rie Andoh, Tsubasa Saito, Isamu Suzuki, Hiroyuki Kanemitsu, Daisuke Suzuki, Ken Goto, Daichi Nakamura, Masahiro Mochizuki, Masahiko Yasuda, Ryo Inoue, Kazutoshi Tamura, Mariko Nagatani
To obtain background data of NOD/Shi-scid IL-2Rγ(null) (NOG) mice, severely immunedeficient mice, a total of 120 animals were examined at 7, 26 and 52 weeks-old (20 mice/sex/group). The survival rate at 52 weeks-old was 95% (19/20) in both sexes. Clinically, circling behavior in one direction along the cage wall was observed in males after 8 weeks and females after 47 weeks-old, and hunchback position was found in males after 32 weeks-old. Hematologically, lymphocyte count markedly decreased at all ages, while white blood cell count increased in several mice at 52 weeks-old...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29141434/dynamic-heterogeneity-in-an-orientational-glass
#10
Nirvana B Caballero, Mariano Zuriaga, Josep Lluís Tamarit, Pablo Serra
The family of compounds CBrnCl4-n has been proven helpful in unraveling microscopic mechanisms responsible for glassy behavior. Some of the family members show translational ordered phases with minimal disorder which appears to reveal glassy features, thus deserving special attention in the search for universal glass anomalies. In this work, we studied CBrCl3 dynamics by performing extensive molecular dynamics simulations. Molecules of this compound perform reorientational discrete jumps, where the atoms exchange equivalent positions among each other revealing a cage-orientational jump motion fully comparable to the cage-rototranslational jump motion in supercooled liquids...
November 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29132425/establishment-of-a-medium-scale-mosquito-facility-optimization-of-the-larval-mass-rearing-unit-for-aedes-albopictus-diptera-culicidae
#11
Dongjing Zhang, Meichun Zhang, Yu Wu, Jeremie R L Gilles, Hanano Yamada, Zhongdao Wu, Zhiyong Xi, Xiaoying Zheng
BACKGROUND: Standardized larval rearing units for mosquito production are essential for the establishment of a mass-rearing facility. Two larval rearing units, developed respectively by the Guangzhou Wolbaki Biotech Co. Ltd. (Wolbaki) and Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture (FAO/IAEA-IPCL), are tested to assess their potential uses to mass-rear the larval stages of Aedes albopictus in support of the establishment of a medium-scale mosquito facility for the application of mosquito genetic control strategies...
November 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29129115/innovative-layer-genetics-to-handle-global-challenges-in-egg-production
#12
R Preisinger
1. In commercial layer breeding, extensive gene pools are tested and selected for market requirements which must be anticipated at least five years ahead. Field results confirm a continuous positive genetic trend in egg output and better feed efficiency which can be converted into land savings. 2. Animal welfare and cage-free housing dominate future needs of the market. Nesting behaviour and minimal tendency to develop feather-pecking or cannibalism without beak treatment, are key trait complexes. Stronger shells for longer production cycles without moulting have to be combined with better bones...
November 13, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29125823/failure-of-an-expandable-cage-plate-cervical-vertebral-body-replacement-case-report-of-a-device-related-complication
#13
Klemens Trieb, Stephan Koch
Instabilities of the cervical spine after complete or incomplete corpectomy may be the result from resection due to stenosis induced myelopathy, tumors, infections or fractures. In this article, we report a 49-year-old female patient after surgical decompression and stabilization at C5/7 with permanent cervicobrachialgia due to cervical stenosis at C5/7. Corpectomy of C6 and stabilization of C5/7 were performed with a combination of cage and plate. At an outpatient control 16 months after reoperation, the patient complained of neck pain, while the control X-ray showed a fracture of the implant...
December 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29125254/field-cage-insecticide-resistance-tests-against-culex-quinquefasciatus-say-diptera-culicidae-in-harris-county-texas-u-s-a
#14
Pamela M Stark, Chris L Fredregill, Melissa S Nolan, Mustapha Debboun
The ground adulticiding program in densely populated Harris County has been employed on the basis of virus-positive mosquitoes almost exclusively using the 'rotation of chemicals best practices' stratagem. To evaluate its effectiveness, 15 comparative field cage testing events were conducted from 2011-2015 using seven wild population samples from repeatedly collected locations of Culex quinquefasciatus Say and a laboratory susceptible Sebring strain colony reared to adults. A 3 × 3 plot design was employed for exposure to ultra-low volume applications of malathion and synergized permethrin...
December 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/29124479/study-on-the-computer-aided-design-of-high-energetic-compounds-based-on-the-1-2-3-4-tetrazine-1-3-dioxide-frame
#15
Wei-Peng Lai, Tao Yu, Ying-Zhe Liu, Yi-Ding Ma, Peng Lian, Zhong-Xue Ge, Jian Lv
In order to discover more potential high energy compounds, five computer-aided design methods were founded, and 20 high energetic compounds based on the 1,2,3,4-tetrazine-1,3-dioxide frame were designed. The first step of computer-aided design methods was to design new frame M. Three combination rules were invented, they were simple double-points rule, complicated double-points rule, and complicated multi-points rule. The second step of computer-aided design methods was to design 1,2,3,4-tetrazine 1,3-dioxides derivants by connecting M to 1,2,3,4-tetrazine-1,3-dioxides...
November 9, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29120948/parvalbumin-containing-gaba-cells-and-schizophrenia-experimental-model-based-on-targeted-gene-delivery-through-adeno-associated-viruses
#16
Marta U Woloszynowska-Fraser, Peer Wulff, Gernot Riedel
Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29114648/structure-and-stability-of-small-lithium-chloride-linclm-0-1-n-%C3%A2-m-n-1-6-m-1-3-clusters
#17
Milan Milovanović, Suzana Veličković, Filip Veljković, Stanka Jerosimić
In the present study, we report the results of a detailed theoretical investigation along with the experimental observations of chlorine-doped small lithium clusters. The cluster ions of the type LinClm(+) (n ≥ m, n = 1-6, m = 1-3) were obtained by the evaporation of LiCl from a Knudsen cell as a chemical reactor in the temperature range between 1800 and 2700 K. Heterogeneous clusters with more than one Cl atom are produced and detected for the first time, and the experimental conditions for formation and stability are examined...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29107217/ultrasensitive-mri-detection-of-spontaneous-pancreatic-tumors-with-nanocage-based-targeted-contrast-agent
#18
Takahito Kawano, Masaharu Murata, Jeong-Hun Kang, Jing Shu Piao, Sayoko Narahara, Fuminori Hyodo, Nobuhito Hamano, Jie Guo, Susumu Oguri, Kenoki Ohuchida, Makoto Hashizume
Contrast agents with greater specificity and sensitivity are required for the diagnosis of pancreatic cancers by magnetic resonance imaging (MRI). In this study, small heat shock protein 16.5 (Hsp16.5)-based nanocages conjugated to gadolinium(III)-chelated contrast agents and iRGD peptides (which target neuropilin-1 expressed on pancreatic cancer cells) were developed. To investigate whether template size influences relaxivity, nanocages with one to four hydrophobic domains were designed. MRI data showed that larger nanocages had higher T1 relaxivity than smaller nanocages, which resulted from a reduction in molecular tumbling rates caused by an increase in nanocage size, and a robust cage structure resulting from the introduction of hydrophobic domains...
October 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/29106896/the-rib-cage-reduces-intervertebral-disc-pressures-in-cadaveric-thoracic-spines-by-sharing-loading-under-applied-dynamic-moments
#19
Dennis E Anderson, Erin M Mannen, Rebecca Tromp, Benjamin M Wong, Hadley L Sis, Eileen S Cadel, Elizabeth A Friis, Mary L Bouxsein
The effects of the rib cage on thoracic spine loading are not well studied, but the rib cage may provide stability or share loads with the spine. Intervertebral disc pressure provides insight into spinal loading, but such measurements are lacking in the thoracic spine. Thus, our objective was to examine thoracic intradiscal pressures under applied pure moments, and to determine the effect of the rib cage on these pressures. Human cadaveric thoracic spine specimens were positioned upright in a testing machine, and Dynamic pure moments (0 to ±5 N·m) with a compressive follower load of 400 N were applied in axial rotation, flexion - extension, and lateral bending...
October 12, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29104061/post-weaning-social-isolation-of-rats-leads-to-long-term-disruption-of-the-gut-microbiota-immune-brain-axis
#20
Fionn Dunphy Doherty, Siobhain M O'Mahony, Veronica L Peterson, Orla O'Sullivan, Fiona Crispie, Paul D Cotter, Peter Wigmore, Madeleine V King, John F Cryan, Kevin C F Fone
Early-life stress is an established risk for the development of psychiatric disorders. Post-weaning isolation rearing of rats produces lasting developmental changes in behavior and brain function that may have translational pathophysiological relevance to alterations seen in schizophrenia, but the underlying mechanisms are unclear. Accumulating evidence supports the premise that gut microbiota influence brain development and function by affecting inflammatory mediators, the hypothalamic-pituitary-adrenal axis and neurotransmission, but there is little knowledge of whether the microbiota-gut-brain axis might contribute to the development of schizophrenia-related behaviors...
November 2, 2017: Brain, Behavior, and Immunity
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