Tracy R Richardson, Bronwyn Smith, Stephanus T Malherbe, Jane Alexandra Shaw, Firdows Noor, Candice MacDonald, Gian D van der Spuy, Kim Stanley, Alida Carstens, Tarryn-Lee Fisher, Ilana van Rensburg, Marika Flinn, Candice Snyders, Isaac Johnson, Bernadine Fransman, Hazel Dockrell, Guy Thwaites, Nguyen Thuy Thuong Thuong, Claudia Schacht, Harriet Mayanja-Kizza, Mary Nsereko, Elisa M Tjon Kon Fat, Paul L A M Corstjens, Annemieke Geluk, Morton Ruhwald, Adam Penn-Nicholson, Novel N Chegou, Jayne Sutherland, Gerhard Walzl
BACKGROUND: To improve tuberculosis (TB) diagnosis, the World Health Organisation (WHO) has called for a non-sputum based triage test to focus TB testing on people with a high likelihood of having active pulmonary tuberculosis (TB). Various host or pathogen biomarker-based testing devices are in design stage and require validity assessment. Host biomarkers have shown promise to accurately rule out active TB, but further research is required to determine generalisability. The TriageTB diagnostic test study aims to assess the accuracy of diagnostic test candidates, as well as field-test, finalise the design and biomarker signature, and validate a point-of-care multi-biomarker test (MBT)...
July 3, 2023: BMC Infectious Diseases