keyword
Keywords Radiology tuberculosis smear c...

Radiology tuberculosis smear culture

https://read.qxmd.com/read/38544531/treatment-outcome-of-drug-resistant-skeletal-tuberculosis-a-retrospective-analysis
#1
JOURNAL ARTICLE
Himanshu Gupta, Rajesh Arora, Manish Chadha, I K Dhammi, Anil K Jain
BACKGROUND: Management outcomes of drug-resistant (DR) osteoarticular tuberculosis (OATB) is dismal as in pre-ATT era (1905). The studies documenting treatment outcome of DR-OATB are scarce; hence, present retrospective analysis was conducted to evaluate outcome of consecutive cases of DR-OATB. METHODS: 45 consecutive patients of suspected DR-OATB were treated from 2010 onwards. Tissue samples were submitted for AFB smear, cytology/histology, liquid culture, CBNAAT/LPA besides gram's staining and aerobic/anaerobic culture...
April 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38437810/utility-of-rapid-on-site-evaluation-during-bronchoscopy-in-the-diagnosis-of-pulmonary-tuberculosis
#2
JOURNAL ARTICLE
Tao Wan, Qianfang Hu, Weiwei Hu, Hongli Deng, Dairong Li
Introduction:The diagnostic value of rapid on-site evaluation (ROSE) in bronchoscopy for lung tumors has been widely researched. However, the diagnostic efficacy of ROSE for pulmonary tuberculosis has not been extensively assessed yet. This study aimed to examine the value of ROSE in diagnosing pulmonary tuberculosis during bronchoscopy, and the relationship between ROSE cytology patterns and acid-fast bacilli (AFB) smears and mycobacterial cultures. Methods:A retrospective study was conducted at a single respiratory endoscopy centre, including 418 patients under clinical or radiological suspicion of having pulmonary tuberculosis who underwent bronchoscopy...
March 4, 2024: Acta Cytologica
https://read.qxmd.com/read/38390008/-drug-resistant-pulmonary-tuberculosis-at-maradi-regional-hospital-center-niger-2014-2018
#3
JOURNAL ARTICLE
Mahaman Laouali Harouna Amadou, Ibrahim Maman Lawan, Ousmane Abdoulaye, Abdoul Kadir Ibrahim Mamadou, Oumarou Amadou, Hassane Boureima, Biraima Ahamadou, Nouhou Hama Aghali, Nana Hadiza Abdourahamane Maifada, Abdoulaziz Kabirou Amoussa, Chaibou Maidakouale
AIM OF STUDY: To describe the clinical, therapeutic and evolutionary profile of patients followed for rifampicin-resistant pulmonary tuberculosis (RR-TB) at the Regional Hospital Centre (RHC) of Maradi (Niger) from 2014 to 2018. METHODS: We conducted a retrospective and descriptive study based on the records of patients followed for Multidrug-resistant tuberculosis (MDR-TB) between January 1, 2014 and June 30, 2018 at the resistant tuberculosis management unit in Maradi (Niger)...
December 31, 2023: Med Trop Sante Int
https://read.qxmd.com/read/38321395/a-novel-diagnostic-model-for-tuberculous-meningitis-using-bayesian-latent-class-analysis
#4
JOURNAL ARTICLE
Trinh Huu Khanh Dong, Joseph Donovan, Nghiem My Ngoc, Do Dang Anh Thu, Ho Dang Trung Nghia, Pham Kieu Nguyet Oanh, Nguyen Hoan Phu, Vu Thi Ty Hang, Nguyen Van Vinh Chau, Nguyen Thuy Thuong Thuong, Le Van Tan, Guy E Thwaites, Ronald B Geskus
BACKGROUND: Diagnosis of tuberculous meningitis (TBM) is hampered by the lack of a gold standard. Current microbiological tests lack sensitivity and clinical diagnostic approaches are subjective. We therefore built a diagnostic model that can be used before microbiological test results are known. METHODS: We included 659 individuals aged [Formula: see text] years with suspected brain infections from a prospective observational study conducted in Vietnam. We fitted a logistic regression diagnostic model for TBM status, with unknown values estimated via a latent class model on three mycobacterial tests: Ziehl-Neelsen smear, Mycobacterial culture, and GeneXpert...
February 6, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38254003/the-clinical-significance-of-plasma-scd25-as-valuable-biomarker-for-progression-and-prognosis-of-tuberculosis
#5
JOURNAL ARTICLE
Xin Yu, Yayan Niu, Junchi Xu, Xiaolong Zhang, Haiyan Wu, Yuhan Wang, Jianping Zhang, Meiying Wu
BACKGROUND: sCD25 is an important immune molecule for T cell regulation. Tracking the detection of plasma sCD25 plays an important role in the evaluation of immune function, progression, and prognosis of tuberculosis (TB) patients. This study analyzed the association of plasma sCD25 levels with clinical, laboratory, CT imaging characteristics, and clinical outcome of TB patients. METHODS: The clinical data of 303 TB patients treated in the Fifth People's Hospital of Suzhou from October 2019 to January 2022 were retrospectively analyzed...
January 22, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/37970079/brain-tuberculoma-a-52-year-old-woman-case-report
#6
Gokul S Shankar, Sreeja Nair, Teena Jacob, Mercy John Idikula
INTRODUCTION: One of the most serious extrapulmonary type of tuberculosis that affects people under the age of 40 is brain tuberculoma. They are space-occupying masses of granulomatous tissue that result from hematogenous spread from a distant focus of tuberculous infection by Mycobacterium tuberculosis . Symptoms and radiologic features being nonspecific usually leads to misdiagnosis and mimics a variety of other infectious diseases. Anti-tubercular drugs are essential for the successful treatment of cerebral tuberculomas...
2023: Access microbiology
https://read.qxmd.com/read/37796343/genexpert-ultra-in-urine-samples-for-diagnosis-of-extra-pulmonary-tuberculosis
#7
JOURNAL ARTICLE
Urvashi B Singh, K P Angitha, Anuj Bhatnagar, Sangeeta Sharma, Raunak Bir, Kiran Singh, Pamela Nabeta, Morten Ruhwald, Sushil K Kabra, Rakesh Lodha
Extra-pulmonary tuberculosis (EPTB) continues to be difficult to diagnose. Novel biomarkers in biological specimens offer promise. Detection of Mycobacterium tuberculosis (Mtb) DNA in urine could prove useful in diagnosis of EPTB, possibly due to disseminated disease or micro-abscesses reported in kidneys. The current study was designed to detect Mtb DNA in stored urine samples from patients with EPTB. Diagnosis of EPTB was reached using Microbiological Reference Standards (MRS) on samples from the disease site using WHO Recommended Diagnostics (WRD), [smear microscopy, liquid culture (MGIT-960)] and GX (molecular WRD, mWRD) and Comprehensive reference standards [CRS, clinical presentation, microbiological reference standards, radiology, histopathology]...
October 5, 2023: Current Microbiology
https://read.qxmd.com/read/37787357/rapid-diagnosis-of-tb-using-aptamer-based-assays-for-mycobacterium-tuberculosis-antigens-in-children-and-adolescents
#8
JOURNAL ARTICLE
Rajesh Bethu, Hema Gupta Mittal, Tarun K Sharma, Anuradha Shulania, Neera Sharma, Shmitha Rangarajan, Prerna Jain
BACKGROUND: Despite advances establishing microbiological evidence of tuberculosis (TB) is still a concern in children due to the limitation of availability of sample and predominance of extrapulmonary TB, there is unmet need for diagnostic tests which are low cost, rapid and sensitive and specific. METHODS: This study evaluated the utility of aptamer-based assay for detecting mycobacterium tuberculosis antigens HspX and MPT 64 in rapid diagnosis of TB in children up to 18 years of age in a tertiary medical college...
2023: Lung India: Official Organ of Indian Chest Society
https://read.qxmd.com/read/37753014/drug-resistance-in-osteoarticular-tuberculosis-a-study-from-an-endemic-zone
#9
JOURNAL ARTICLE
Amartya Gain, Anil K Jain, Manpreet Bhalla, Aditya N Aggarwal, Ish K Dhammi, Vinod K Arora
The present study was undertaken to determine the incidence of drug resistance against anti-tubercular drugs among patients from an endemic zone.  Methodology: Forty consecutive clinico-radiologically diagnosed patients of osteoarticular tuberculosis (29: spine, 11: extraspinal) were enrolled. Pus from needle aspiration was taken in 31 cases, tissue following spinal decompression in seven, synovial in one, and sinus edge biopsy in one. The pus/tissue was subjected to acid-fast bacilli (AFB) staining and liquid culture, sensitivity to 13 anti-tubercular drugs (Isoniazid (INH), rifampicin (RIF), kanamycin (KAN), amikacin (AMK,) capreomycin (CAP), ethionamide (ETH), levofloxacin (LEV), moxifloxacin (MOX), linezolid (LNZ), para-amino-salicylic acid (PAS), bedaquiline (BDQ), delamanid (DLM), and clofazimine (CFO)) were checked, and histopathological/cytopathological examination and molecular tests were performed...
August 2023: Curēus
https://read.qxmd.com/read/37400753/field-evaluation-of-a-point-of-care-triage-test-for-active-tuberculosis-triagetb
#10
JOURNAL ARTICLE
Tracy R Richardson, Bronwyn Smith, Stephanus T Malherbe, Jane Alexandra Shaw, Firdows Noor, Candice MacDonald, Gian D van der Spuy, Kim Stanley, Alida Carstens, Tarryn-Lee Fisher, Ilana van Rensburg, Marika Flinn, Candice Snyders, Isaac Johnson, Bernadine Fransman, Hazel Dockrell, Guy Thwaites, Nguyen Thuy Thuong Thuong, Claudia Schacht, Harriet Mayanja-Kizza, Mary Nsereko, Elisa M Tjon Kon Fat, Paul L A M Corstjens, Annemieke Geluk, Morton Ruhwald, Adam Penn-Nicholson, Novel N Chegou, Jayne Sutherland, Gerhard Walzl
BACKGROUND: To improve tuberculosis (TB) diagnosis, the World Health Organisation (WHO) has called for a non-sputum based triage test to focus TB testing on people with a high likelihood of having active pulmonary tuberculosis (TB). Various host or pathogen biomarker-based testing devices are in design stage and require validity assessment. Host biomarkers have shown promise to accurately rule out active TB, but further research is required to determine generalisability. The TriageTB diagnostic test study aims to assess the accuracy of diagnostic test candidates, as well as field-test, finalise the design and biomarker signature, and validate a point-of-care multi-biomarker test (MBT)...
July 3, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37252024/diagnostic-utility-of-bronchoalveolar-lavage-in-immunocompromised-patients-with-lung-infiltrates
#11
JOURNAL ARTICLE
Ahmed Aljishi, Deemah Alalbdulhadi, Ghadeer Alabbadi, Mohammed Hashim Ali, Melissa K Ivey, Zainab Almusa, Rayid Abdulqawi
INTRODUCTION: Lung infections are associated with a high mortality rate in immunocompromised patients. Achieving an accurate and rapid diagnosis is vital to help guide management, and thus improve survival. OBJECTIVE: To establish the diagnostic yield, clinical value, and safety of bronchoscopy with bronchoalveolar lavage (BAL) in immunocompromised adult patients with pulmonary infiltrates. METHODS: This retrospective study included all immunocompromised adult patients who underwent bronchoscopy with BAL for investigation of radiologically confirmed pulmonary infiltrates at a tertiary care hospital between January 01, 2014, and June 30, 2021...
2023: Saudi Journal of Medicine & Medical Sciences
https://read.qxmd.com/read/36969920/time-to-sputum-conversion-in-patients-with-pulmonary-tuberculosis-a-score-to-estimate-the-infectious-period
#12
JOURNAL ARTICLE
Maria Ramirez-Hidalgo, Javier Trujillano-Cabello, Adrià Espluges-Vidal, Mercé Reñé-Reñé, Miguel Santín, Adrián Sánchez-Montalvá, Albert Bernet-Sánchez, Laura Gros-Navés, Miquel Falguera
INTRODUCTION: Patients with pulmonary tuberculosis (PTB) disease and positive sputum cultures are the main source of infection. Culture conversion time is inconsistent and defining the length of respiratory isolation is challenging. The objective of this study is to develop a score to predict the length of isolation period. METHODS: A retrospective study was carried out to evaluated risk factors associated with persistent positive sputum cultures after 4 weeks of treatment in 229 patients with PTB...
May 2023: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://read.qxmd.com/read/36966795/the-natural-history-of-untreated-pulmonary-tuberculosis-in-adults-a-systematic-review-and-meta-analysis
#13
REVIEW
Bianca Sossen, Alexandra S Richards, Torben Heinsohn, Beatrice Frascella, Federica Balzarini, Aurea Oradini-Alacreu, Anna Odone, Ewelina Rogozinska, Brit Häcker, Frank Cobelens, Katharina Kranzer, Rein M G J Houben, Hanif Esmail
Stages of tuberculosis disease can be delineated by radiology, microbiology, and symptoms, but transitions between these stages remain unclear. In a systematic review and meta-analysis of studies of individuals with untreated tuberculosis who underwent follow-up (34 cohorts from 24 studies, with a combined sample of 139 063), we aimed to quantify progression and regression across the tuberculosis disease spectrum by extracting summary estimates to align with disease transitions in a conceptual framework of the natural history of tuberculosis...
April 2023: Lancet Respiratory Medicine
https://read.qxmd.com/read/36874681/long-term-follow-up-results-of-granulomatous-lymphadenitis-diagnosed-by-endobronchial-ultrasound-guided-fine-needle-aspiration-biopsy
#14
JOURNAL ARTICLE
Nevra Gullu Arslan, İlker Yilmam
Introduction Endobronchial ultrasound-guided fine-needle aspiration biopsy (EBUS-FNAB) is a minimally invasive method used to obtain cytological or histological specimens of masses and lymphadenopathies (LAP) adjacent to the trachea and bronchi. Granulomas, which represent a chronic inflammatory response and occur for a variety of reasons, like a 'sarcoid-like reaction', cause LAPs. In this study, it was aimed to evaluate the long-term follow-up results of granulomatous lymphadenitis diagnosed with EBUS-FNAB and to investigate whether granulomatous lymphadenopathies were precursors of malignancies that occurred during the follow-up period...
January 2023: Curēus
https://read.qxmd.com/read/36668920/the-role-of-post-bronchoscopy-sputum-examination-in-screening-for-active-tuberculosis
#15
JOURNAL ARTICLE
Gawahir A Ali, Wael Goravey, Faraj S Howady, Maisa Ali, Awni Alshurafa, Ahmed M Abdalhadi, Muhammed Hajmusa, Joanne Daghfal, Abdullatif Al Khal, Muna Al Maslamani, Hussam Al Soub, Ali S Omrani
Early diagnosis is a fundamental component of global tuberculosis control. The objective of this study was to evaluate the diagnostic yield of post-bronchoscopy sputum (PBS) testing as part of a tuberculosis diagnostic work-up. All new residents in the State of Qatar undergo a tuberculosis (TB) screening program. Those with abnormal chest radiology, negative sputum acid-fast bacilli (AFB) smears, and nucleic acid amplification testing (NAAT) for M. tuberculosis , undergo an additional bronchoscopic evaluation for TB...
December 26, 2022: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/36618196/study-of-diagnostic-utility-of-xpert-mtb-rif-test-on-pleural-fluid-in-the-evaluation-of-patients-presenting-with-pleural-tuberculosis-in-nepal
#16
JOURNAL ARTICLE
Deebya Raj Mishra, Narendra Bhatta, Madhab Lamsal, Narayan Bhattarai, Robin Maskey, Niharika Shah
INTRODUCTION: Existing tests for the diagnosis of pleural tuberculosis (TB) have major limitations in terms of accuracy, time to diagnosis and drug resistance testing. A test which can diagnose pleural TB and detect resistance, like Xpert MTB/Rif, would be optimal for rapid diagnosis and treatment. METHODS: A prospective observational study was done in a tertiary care hospital in Eastern Nepal. Fifty-one patients with clinic-radiologic suspicion of pleural TB were included...
October 2022: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/36530886/sputum-smear-conversion-and-treatment-outcomes-among-drug-resistant-pulmonary-tuberculosis-patients-in-eastern-ethiopia-a-9-years-data-analysis
#17
JOURNAL ARTICLE
Mulugeta Gamachu, Alemayehu Deressa, Abdi Birhanu, Galana Mamo Ayana, Temam Beshir Raru, Belay Negash, Bedasa Taye Merga, Addisu Alemu, Fila Ahmed, Ahmed Mohammed, Ibsa M Abdulahi, Lemma Demissei Regassa
BACKGROUND: Drug-resistant tuberculosis (DR-TB) has become a public health problem throughout the world and about one-third of deaths were attributed to DR-TB from antimicrobial resistance which contributes to 10% of all TB deaths. Sub-Saharan Africa, particularly Ethiopia accounts for a significant number of TB cases. However, the scanty evidence on DR-TB contributing factors could affect the level of this deadly case tackling program. Therefore, this study aimed to assess the factors affecting sputum smear conversion and treatment outcomes among patients with DR-TB in Health facilities in Eastern Ethiopia...
2022: Frontiers in Medicine
https://read.qxmd.com/read/36510924/a-prospective-study-of-the-clinical-profile-of-hemoptysis-and-its-correlation-with-radiological-and-microbiological-findings
#18
JOURNAL ARTICLE
Harveen Kaur, Naveen Pandhi, N C Kajal
BACKGROUND: The etiological pattern of hemoptysis has evolved, with pulmonary tuberculosis (PTB) becoming less prevalent as a cause. There is a paucity of literature regarding the spectrum of diseases that present as hemoptysis and the data related to detailed clinical profile are lacking. Hence, this study is taken up to determine the clinical profile of hemoptysis and its correlation with radiological and microbiological findings. METHODS: This was a 3-year observational prospective study of a total of 50 patients who presented with active hemoptysis...
2022: International Journal of Mycobacteriology
https://read.qxmd.com/read/36465947/tuberculosis-and-covid-19-co-infection-in-serbia-pandemic-challenge-in-a-low-burden-country
#19
JOURNAL ARTICLE
Tatjana Adzic-Vukicevic, Maja Stosic, Gordana Antonijevic, Miroslav Jevtic, Aleksandra Radovanovic-Spurnic, Jelena Velickovic
INTRODUCTION: COVID-19 and tuberculosis (TB) represent global threats to the public health system. The impact of COVID-19 on TB results in a reduction in the number of notified TB cases, delayed diagnosis and treatment, and increased case fatality and mortality rates. The aim of the study was to analyze the TB/COVID-19 co-infected cohort in Serbia as a low-burden country and compare it to the global TB/COVID-19 cohort. METHODS: A retrospective analysis was done on 53 TB and COVID-19 co-infected patients treated in COVID hospital "Batajnica" in Belgrade and Special Hospital for Pulmonary Diseases "Ozren" Sokobanja in the period from 6 March 2020 to 1 April 2022...
2022: Frontiers in Medicine
https://read.qxmd.com/read/36460388/role-of-gene-xpert-in-smear-negative-pulmonary-tuberculosis
#20
JOURNAL ARTICLE
Hena Mustafa, Naveed N Shah, Mir Shahnawaz, Mohammad Yousuf
BACKGROUND: Tuberculosis is a major health problem contributing to significant morbidity and mortality. Early diagnosis and treatment is the key for TB control. Sputum microscopy is a rapid and inexpensive test but due to low and variable sensitivity, many cases can be missed. Culture is considered to be the gold standard but is time consuming. Gene Xpert is a novel and rapid cartridge based nucleic acid amplification test (CBNAAT) that can be used for prompt diagnosis. AIM: To compare the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of Gene Xpert with culture in diagnosing tuberculosis in sputum smear negative patients...
October 2022: Indian Journal of Tuberculosis
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