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Neurological disorders and exercise

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https://www.readbyqxmd.com/read/29775977/-rehabilitation-after-traumatic-fracture-of-thoracic-and-lumbar-spine
#1
Hartmut Bork, Stefan Simmel, Eckhardt Böhle, Ulrich Ernst, Klaus Fischer, Bernd Fromm, Jean-Jacques Glaesener, Bernhard Greitemann, P Krause, S Panning, V Pullwitt, J Schmidt, Andreas Veihelmann, Lutz Vogt
On the basis of the S2-k guideline "Rehabilitation after traumatic fractures of the thoracic und lumbar spine without neurologic disorder", this article gives an overview of target-oriented rehabilitation of patients with minor fractures or those with column stability and unstable spinal fractures which are stabilised by surgery. To obtain early social and job related reintegration, outpatient or inpatient rehabilitation has to start immediately after treatment in hospital. Rehabilitation must be orientated towards the biopsychosocial model of ICF and has to be adapted for the patient...
May 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29774194/improper-use-of-thrombolytic-agents-in-acute-hemiparesis-following-misdiagnosis-of-acute-ischemic-stroke
#2
Min Chan Kim, Seok Won Kim
Objective: Acute hemiparesis is often an early presentation of acute ischemic stroke, though it can occur in various disorders. This study aimed to investigate the improper use of thrombolytic agents for patients with acute hemiparesis, following the misdiagnosis of acute ischemic stroke. Methods: We analyzed the clinical and radiological data of nine patients initially misdiagnosed with cerebral stroke in the emergency room from May 2013 to January 2017. All the patients were treated with tissue plasminogen activator (TPA) owing to the presence of acute hemiparesis...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29771692/the-expanding-spectrum-of-paroxysmal-movement-disorders-update-from-clinical-features-to-therapeutics
#3
Eavan M McGovern, Emmanuel Roze, Timothy J Counihan
PURPOSE OF REVIEW: This review will discuss the expanding clinical spectrum of paroxysmal movement disorders and therapeutic options in light of emerging genotypic heterogeneity in these conditions. RECENT FINDINGS: Paroxysmal movement disorders comprise a heterogeneous group of rare neurological conditions characterized by intermittent episodes of abnormal movement associated with various triggers. As the clinical and genotypic spectrum of these disorders evolves, so also has the range of therapeutic options...
May 15, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29731703/metabolic-syndrome-and-neuroprotection
#4
REVIEW
Melisa Etchegoyen, Mariana H Nobile, Francisco Baez, Barbara Posesorski, Julian González, Néstor Lago, José Milei, Matilde Otero-Losada
Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder. Undoubtedly, the massive and still increasing incidence of MetS places this epidemic as an important public health issue. Hereon we revisit another outlook of MetS beyond its classical association with cardiovascular disease (CVD) and Diabetes Mellitus Type 2 (DM2), for MetS also poses a risk factor for the nervous tissue and threatens neuronal function...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29720792/preventing-neurophobia-remodeling-neurology-education-for-21-st-century-medical-students-through-effective-pedagogical-strategies-for-neurophilia
#5
REVIEW
Bhaskara P Shelley, Thomas V Chacko, Balakrishnan R Nair
Neurology has a reputation, particularly as a complex "head-to-toe" discipline for undergraduate medical students. Neurophobia syndrome, a global phenomenon, fundamentally stems from pedagogical deficiencies during the undergraduate curriculum, the lack of vertical integration between basic neurosciences and clinical bedside neurology, the lack of clinical reasoning exercises, cognitive heuristics, and clinical problem-solving, errors in diagnostic competence, and hyposkilia. This ultimately results in poor clinical competence and proficiency in clinical neurology and causes attrition in nurturing a passion for learning the neurology discipline...
January 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29683810/evidence-of-the-homeostatic-regulation-with-the-combination-of-transcranial-direct-current-stimulation-and-physical-activity
#6
Adriana Baltar, Fernanda Nogueira, Déborah Marques, Maíra Carneiro, Kátia Monte-Silva
Transcranial direct current stimulation (tDCS) can optimize beneficial effects induced by motor practice in patients with neurological disorders. However, possibly due to homeostatic regulation, the conditioning effects of tDCS are often imprecise and variable, limiting its therapeutic application. OBJECTIVE: to explore the magnitude and direction of the after-effects induced by physical activity (PA) on tDCS-preconditioned cortical excitability (CE). DESIGN: First, a crossover experiment was performed with 12 subjects to determine whether a single session of low-, moderate- and high-intensity PA on a treadmill modulates the motor cortical excitability measured by transcranial magnetic stimulation...
April 20, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29667473/harnessing-neuroplasticity-modern-approaches-and-clinical-future
#7
Andrew Octavian Sasmita, Joshua Kuruvilla, Anna Pick Kiong Ling
Neurological diseases and injuries to the nervous system may cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would catastrophically accumulate, leading to the development of neurological and neurodegenerative disorders which might affect memory, cognition, and motoric functions. The body has various negative feedback systems which are able to induce beneficial neuroplastic changes in mediating some neuronal damage, however, such efforts are often not enough to ameliorate the derogatory changes...
April 18, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29610328/ectopic-neurogenesis-induced-by-prenatal-antiepileptic-drug-exposure-augments-seizure-susceptibility-in-adult-mice
#8
Atsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, Kinichi Nakashima
Epilepsy is a neurological disorder often associated with seizure that affects ∼0.7% of pregnant women. During pregnancy, most epileptic patients are prescribed antiepileptic drugs (AEDs) such as valproic acid (VPA) to control seizure activity. Here, we show that prenatal exposure to VPA in mice increases seizure susceptibility in adult offspring through mislocalization of newborn neurons in the hippocampus. We confirmed that neurons newly generated from neural stem/progenitor cells (NS/PCs) are integrated into the granular cell layer in the adult hippocampus; however, prenatal VPA treatment altered the expression in NS/PCs of genes associated with cell migration, including CXC motif chemokine receptor 4 ( Cxcr4 ), consequently increasing the ectopic localization of newborn neurons in the hilus...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29522363/mri-to-investigate-iliac-artery-wall-thickness-in-triathletes
#9
Susanne Regus, Veronika Almási-Sperling, Rolf Janka, Ulrich Rother, Michael Lell, Alexander Meyer, Werner Lang
OBJECTIVES: Endofibrosis was first described in endurance athletes. This rare disease is characterized by intimal hyperplasia of iliac arteries. Due to non-specific symptoms diagnosing could be very challenging and delayed. This represents a serious problem not only for affected athletes but also for consulting physicians. The aim of this study was to analyze intimal thickness of iliac arteries using non-contrast magnetic resonance imaging (MRI) in competitive triathletes suffering from exercise induced leg pain consistent with symptoms caused by endofibrosis...
March 9, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29398000/an-instrumental-approach-for-monitoring-physical-exercises-in-a-visual-markerless-scenario-a-proof-of-concept
#10
Marianna Capecci, Maria Gabriella Ceravolo, Francesco Ferracuti, Martina Grugnetti, Sabrina Iarlori, Sauro Longhi, Luca Romeo, Federica Verdini
This work proposes a real-time monitoring tool aimed to support clinicians for remote assessing exercise performances during home-based rehabilitation. The study relies on clinician indications to define kinematic features, that describe five motor tasks (i.e., the lateral tilt of the trunk, lifting of the arms, trunk rotation, pelvis rotation, squatting) usually adopted in the rehabilitation program for axial disorders. These features are extracted by the Kinect v2 skeleton tracking system and elaborated to return disaggregated scores, representing a measure of subjects performance...
March 1, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29385732/biomarkers-for-detecting-mitochondrial-disorders
#11
REVIEW
Josef Finsterer, Sinda Zarrouk-Mahjoub
(1) Objectives: Mitochondrial disorders (MIDs) are a genetically and phenotypically heterogeneous group of slowly or rapidly progressive disorders with onset from birth to senescence. Because of their variegated clinical presentation, MIDs are difficult to diagnose and are frequently missed in their early and late stages. This is why there is a need to provide biomarkers, which can be easily obtained in the case of suspecting a MID to initiate the further diagnostic work-up. (2) Methods: Literature review. (3) Results: Biomarkers for diagnostic purposes are used to confirm a suspected diagnosis and to facilitate and speed up the diagnostic work-up...
January 30, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29377139/late-onset-becker-type-muscular-dystrophy-in-a-border-terrier-dog
#12
A Jeandel, L S Garosi, L Davies, L T Guo, R Salgüero, G D Shelton
A 9-year-old Border terrier was presented to a referral hospital after a 1-year history of progressive stiffness and exercise intolerance. Neurological examination was consistent with a neuromuscular disorder. Serum creatine kinase activity was mildly elevated. A myopathy was suspected based on MRI findings and electrophysiological examination. Muscle histopathology was consistent with a severe non-inflammatory myopathy of a dystrophic type. Immunofluorescence and western blotting confirmed a dystrophinopathy with an 80-kDa truncated dystrophin fragment similar to Becker muscular dystrophy in people...
January 29, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29313153/first-symptoms-in-multiple-system-atrophy
#13
Jake H McKay, William P Cheshire
PURPOSE: The initial symptoms of multiple system atrophy (MSA) and, in particular, early autonomic symptoms, have received less attention than motor symptoms. Whereas pathognomonic motor signs are essential to diagnostic specificity, early symptoms important to recognition of a neurodegenerative disorder may be less apparent or diagnostically ambiguous. This observational study sought to identify the very earliest symptoms in the natural history of MSA. METHODS: Detailed clinical histories focusing on early symptoms were obtained from 30 subjects recently diagnosed with MSA...
April 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29282342/-motor-symptoms-of-autoimmune-encephalopathies
#14
Yuichi Tashiro, Hiroshi Takashima
Autoimmune encephalopathies are clinically and immunologically heterogeneous disorders. At least 20 types of autoimmune encephalopathies have been discovered, with the most common type being Hashimoto encephalopathy. In clinical situations, we often observe that patients with autoimmune encephalopathy are misdiagnosed because they exhibit signs similar to those observed in functional psychogenic movement, conversion, or somatoform disorders. We clinically examined over 100 patients with autoimmune encephalopathy...
December 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29276132/getting-the-brain-into-shape-exercise-in-neurological-disorders
#15
EDITORIAL
Jane B Allendorfer, Marcas M Bamman
No abstract text is available yet for this article.
January 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29251846/neurobiology-of-substance-use-in-adolescents-and-potential-therapeutic-effects-of-exercise-for-prevention-and-treatment-of-substance-use-disorders
#16
REVIEW
Nora L Nock, Sonia Minnes, Jay L Alberts
Substance use (e.g., alcohol, marijuana, opioids, cocaine., etc,) use often initiates during adolescence, a critical period of physiological and social development marked by an increase in risk-taking due, in part, to heightened motivation to obtain arousal from rewards. Substance use during adolescence has been associated with a greater risk of substance use disorders (SUD) in adulthood. Although use rates for most substances have remained relatively stable, the frequency of marijuana use and the perception that regular marijuana use is not harmful has increased in adolescents...
December 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/29228079/effect-of-high-intensity-treadmill-exercise-on-motor-symptoms-in-patients-with-de-novo-parkinson-disease-a-phase-2-randomized-clinical-trial
#17
Margaret Schenkman, Charity G Moore, Wendy M Kohrt, Deborah A Hall, Anthony Delitto, Cynthia L Comella, Deborah A Josbeno, Cory L Christiansen, Brian D Berman, Benzi M Kluger, Edward L Melanson, Samay Jain, Julie A Robichaud, Cynthia Poon, Daniel M Corcos
Importance: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. Objectives: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. Design, Setting, and Participants: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors...
February 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29128525/respiratory-rehabilitation-in-multiple-sclerosis-a-narrative-review-of-rehabilitation-techniques
#18
REVIEW
J Levy, H Prigent, D Bensmail
BACKGROUND: Respiratory disorders in multiple sclerosis (MS) are an important issue. They can occur early during the course of the disease, are associated with the neurological impairment, and can lead to pneumonia and respiratory failure, which are the main causes of death in advanced MS. Prevailing impaired expiratory muscles and cough abilities has been demonstrated in this population and might constitute a specific target for rehabilitation interventions. However, international guidelines lack recommendations regarding respiratory rehabilitation in MS...
January 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29057125/the-effect-of-aerobic-exercise-on-brain-derived-neurotrophic-factor-in-people-with-neurological-disorders-a-systematic-review-and-meta-analysis
#19
REVIEW
Christopher P Mackay, Suzanne S Kuys, Sandra G Brauer
OBJECTIVE: To determine the effect of aerobic exercise on brain-derived neurotrophic factor (BDNF) levels in people with neurological disorders. DATA SOURCES: Six electronic databases (CINAHL, PubMed, Cochrane, PsycINFO, SportDiscus, and Web of Science) were searched until the end of December 2016. STUDY SELECTION: Experimental or observational studies of people with neurological disorders who undertook an exercise intervention with BDNF as an outcome measure...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29021780/chronic-5-aminoimidazole-4-carboxamide-1-%C3%AE-d-ribofuranoside-treatment-induces-phenotypic-changes-in-skeletal-muscle-but-does-not-improve-disease-outcomes-in-the-r6-2-mouse-model-of-huntington-s-disease
#20
Marie-France Paré, Bernard J Jasmin
Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercise mimetics (EMs) are a group of drugs and small molecules that target signaling pathways in skeletal muscle known to be activated by endurance exercise. The EM 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) has been shown to induce cognitive benefits in healthy mice...
2017: Frontiers in Neurology
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