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Neurological disorders and exercise

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https://www.readbyqxmd.com/read/29313153/first-symptoms-in-multiple-system-atrophy
#1
Jake H McKay, William P Cheshire
PURPOSE: The initial symptoms of multiple system atrophy (MSA) and, in particular, early autonomic symptoms, have received less attention than motor symptoms. Whereas pathognomonic motor signs are essential to diagnostic specificity, early symptoms important to recognition of a neurodegenerative disorder may be less apparent or diagnostically ambiguous. This observational study sought to identify the very earliest symptoms in the natural history of MSA. METHODS: Detailed clinical histories focusing on early symptoms were obtained from 30 subjects recently diagnosed with MSA...
January 8, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29282342/-motor-symptoms-of-autoimmune-encephalopathies
#2
Yuichi Tashiro, Hiroshi Takashima
Autoimmune encephalopathies are clinically and immunologically heterogeneous disorders. At least 20 types of autoimmune encephalopathies have been discovered, with the most common type being Hashimoto encephalopathy. In clinical situations, we often observe that patients with autoimmune encephalopathy are misdiagnosed because they exhibit signs similar to those observed in functional psychogenic movement, conversion, or somatoform disorders. We clinically examined over 100 patients with autoimmune encephalopathy...
December 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29276132/getting-the-brain-into-shape-exercise-in-neurological-disorders
#3
EDITORIAL
Jane B Allendorfer, Marcas M Bamman
No abstract text is available yet for this article.
December 21, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29251846/neurobiology-of-substance-use-in-adolescents-and-potential-therapeutic-effects-of-exercise-for-prevention-and-treatment-of-substance-use-disorders
#4
REVIEW
Nora L Nock, Sonia Minnes, Jay L Alberts
Substance use (e.g., alcohol, marijuana, opioids, cocaine., etc,) use often initiates during adolescence, a critical period of physiological and social development marked by an increase in risk-taking due, in part, to heightened motivation to obtain arousal from rewards. Substance use during adolescence has been associated with a greater risk of substance use disorders (SUD) in adulthood. Although use rates for most substances have remained relatively stable, the frequency of marijuana use and the perception that regular marijuana use is not harmful has increased in adolescents...
December 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/29228079/effect-of-high-intensity-treadmill-exercise-on-motor-symptoms-in-patients-with-de-novo-parkinson-disease-a-phase-2-randomized-clinical-trial
#5
Margaret Schenkman, Charity G Moore, Wendy M Kohrt, Deborah A Hall, Anthony Delitto, Cynthia L Comella, Deborah A Josbeno, Cory L Christiansen, Brian D Berman, Benzi M Kluger, Edward L Melanson, Samay Jain, Julie A Robichaud, Cynthia Poon, Daniel M Corcos
Importance: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. Objectives: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. Design, Setting, and Participants: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29128525/respiratory-rehabilitation-in-multiple-sclerosis-a-narrative-review-of-rehabilitation-techniques
#6
REVIEW
J Levy, H Prigent, D Bensmail
BACKGROUND: Respiratory disorders in multiple sclerosis (MS) are an important issue. They can occur early during the course of the disease, are associated with the neurological impairment, and can lead to pneumonia and respiratory failure, which are the main causes of death in advanced MS. Prevailing impaired expiratory muscles and cough abilities has been demonstrated in this population and might constitute a specific target for rehabilitation interventions. However, international guidelines lack recommendations regarding respiratory rehabilitation in MS...
November 8, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29057125/the-effect-of-aerobic-exercise-on-brain-derived-neurotrophic-factor-in-people-with-neurological-disorders-a-systematic-review-and-meta-analysis
#7
REVIEW
Christopher P Mackay, Suzanne S Kuys, Sandra G Brauer
OBJECTIVE: To determine the effect of aerobic exercise on brain-derived neurotrophic factor (BDNF) levels in people with neurological disorders. DATA SOURCES: Six electronic databases (CINAHL, PubMed, Cochrane, PsycINFO, SportDiscus, and Web of Science) were searched until the end of December 2016. STUDY SELECTION: Experimental or observational studies of people with neurological disorders who undertook an exercise intervention with BDNF as an outcome measure...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29021780/chronic-5-aminoimidazole-4-carboxamide-1-%C3%AE-d-ribofuranoside-treatment-induces-phenotypic-changes-in-skeletal-muscle-but-does-not-improve-disease-outcomes-in-the-r6-2-mouse-model-of-huntington-s-disease
#8
Marie-France Paré, Bernard J Jasmin
Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercise mimetics (EMs) are a group of drugs and small molecules that target signaling pathways in skeletal muscle known to be activated by endurance exercise. The EM 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) has been shown to induce cognitive benefits in healthy mice...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28961260/biochemical-phenotyping-unravels-novel-metabolic-abnormalities-and-potential-biomarkers-associated-with-treatment-of-glut1-deficiency-with-ketogenic-diet
#9
Gerarda Cappuccio, Michele Pinelli, Marianna Alagia, Taraka Donti, Debra-Lynn Day-Salvatore, Pierangelo Veggiotti, Valentina De Giorgis, Simona Lunghi, Maria Stella Vari, Pasquale Striano, Nicola Brunetti-Pierri, Adam D Kennedy, Sarah H Elsea
Global metabolomic profiling offers novel opportunities for the discovery of biomarkers and for the elucidation of pathogenic mechanisms that might lead to the development of novel therapies. GLUT1 deficiency syndrome (GLUT1-DS) is an inborn error of metabolism due to reduced function of glucose transporter type 1. Clinical presentation of GLUT1-DS is heterogeneous and the disorder mirrors patients with epilepsy, movement disorders, or any paroxysmal events or unexplained neurological manifestation triggered by exercise or fasting...
2017: PloS One
https://www.readbyqxmd.com/read/28951250/combining-aerobic-exercise-and-repetitive-transcranial-magnetic-stimulation-to-improve-brain-function-in-health-and-disease
#10
REVIEW
Joshua Hendrikse, Aaron Kandola, James Coxon, Nigel Rogasch, Murat Yücel
The aetiology of various psychiatric and neurological disorders may be partially attributable to impairments in neuroplasticity. Developing novel methods of stimulating neuroplasticity is a promising treatment approach to counterbalance these maladaptive influences and alleviate symptomologies. Two non-pharmacological approaches with significant and direct impacts on neuroplasticity are aerobic exercise and repetitive transcranial magnetic stimulation. Aerobic exercise is associated with the promotion of numerous neurotrophic mechanisms at a molecular and cellular level, which have a broad influence on neuroplasticity...
September 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28948069/reproducibility-of-quantitative-structural-and-physiological-mri%C3%A2-measurements
#11
Stephen A McGuire, S Andrea Wijtenburg, Paul M Sherman, Laura M Rowland, Meghann Ryan, John H Sladky, Peter V Kochunov
INTRODUCTION: Quantitative longitudinal magnetic resonance imaging and spectroscopy (MRI/S) is used to assess progress of brain disorders and treatment effects. Understanding the significance of MRI/S changes requires knowledge of the inherent technical and physiological consistency of these measurements. This longitudinal study examined the variance and reproducibility of commonly used quantitative MRI/S measurements in healthy subjects while controlling physiological and technical parameters...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28931439/effects-of-whole-body-vibration-exercise-on-neuromuscular-function-for-individuals-with-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#12
Zhangqi Lai, Xueqiang Wang, Seullee Lee, Xihe Hou, Lin Wang
BACKGROUND: Knee osteoarthritis (KOA) is a leading cause of public disability. Neuromuscular function contributes to the development and/or progression of KOA. Whole body vibration (WBV) exercise improve the neuromuscular function of patients with neurological disorders and even that of older patients with limited exercise options. Therefore, WBV exercise may offer an efficient and alternative treatment for individuals with KOA. However, the effects of WBV training on the neuromuscular function of individuals with KOA remain unclear...
September 20, 2017: Trials
https://www.readbyqxmd.com/read/28898133/differential-impact-of-treadmill-training-on-stroke-induced-neurological-disorders
#13
Rasoul Rezaei, Maryam Nourshahi, Fariba Khodagholi, Abbas Haghparast, Sanaz Nasoohi, Mohammadreza Bigdeli, Ghorbangol Ashabi
OBJECTIVE: Physical exercise contributes to improving stability against nerve injury caused by ischaemic stroke. Here we aimed to preliminarily investigate the effects of continuous endurance training (CET) and high-intensity interval training (HIT) on stroke-associated anxiety, locomotion, neurological assessments and P70S6 Kinase (P70S6K) activation as well. To do this, rats were trained according to HIT and CET protocols for 2 months prior to being subject to middle cerebral artery occlusion surgery...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28872110/a-protocol-for-the-administration-of-real-time-fmri-neurofeedback-training
#14
Matthew S Sherwood, Emily E Diller, Elizabeth Ey, Subhashini Ganapathy, Jeremy T Nelson, Jason G Parker
Neurologic disorders are characterized by abnormal cellular-, molecular-, and circuit-level functions in the brain. New methods to induce and control neuroplastic processes and correct abnormal function, or even shift functions from damaged tissue to physiologically healthy brain regions, hold the potential to dramatically improve overall health. Of the current neuroplastic interventions in development, neurofeedback training (NFT) from functional Magnetic Resonance Imaging (fMRI) has the advantages of being completely non-invasive, non-pharmacologic, and spatially localized to target brain regions, as well as having no known side effects...
August 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28860773/can-melatonin-prevent-or-improve-metabolic-side-effects-during-antipsychotic-treatments
#15
Maria-Cristina Porfirio, Juliana Paula Gomes de Almeida, Maddalena Stornelli, Silvia Giovinazzo, Diane Purper-Ouakil, Gabriele Masi
In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28855792/addressing-neurodynamic-irritability-in-a-patient-with-adhesive-capsulitis-a-case-report
#16
Kevin Farrell, Katherine Lampe
BACKGROUND: Patients with adhesive capsulitis are commonly seen by physical therapists. Pain and limited shoulder motion from adhesive capsulitis have at times been linked to neural irritation. The purpose of this case is to describe the examination and intervention of a patient with adhesive capsulitis who appeared to have a coexisting, underlying neural irritation. This paper emphasizes how the neurological component must initially be identified and addressed for a successful outcome...
February 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28795210/-arthrodesis-of-the-trapeziometacarpal-joint
#17
REVIEW
T Pillukat, M Mühldorfer-Fodor, R Fuhrmann, J Windolf, J van Schoonhoven
OBJECTIVE: Bony fusion of the trapeziometacarpal joint. INDICATIONS: High demands concerning stability and strength of the thumb in primary or secondary osteoarthritis (e.g., posttraumatic osteoarthritis following injuries to the carpometacarpal joint of the thumb); instability in the absence of osteoarthritis due to malformations, ligamentous laxicity, and joint hypermobility; malformations; improvement of hand function in neurological disorders; salvage procedure after carpometacarpal arthroplasty provided bone stock is sufficient...
August 9, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28777176/circadian-rhythm-sleep-wake-disorders
#18
Milena Pavlova
PURPOSE OF REVIEW: The endogenous circadian rhythms are one of the cardinal processes that control sleep. They are self-sustaining biological rhythms with a periodicity of approximately 24 hours that may be entrained by external zeitgebers (German for time givers), such as light, exercise, and meal times. This article discusses the physiology of the circadian rhythms, their relationship to neurologic disease, and the presentation and treatment of circadian rhythm sleep-wake disorders...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28712264/treadmill-exercise-ameliorates-the-regulation-of-energy-metabolism-in-skeletal-muscle-of-nse-ps2mtransgenic-mice-with-alzheimer-s-disease
#19
Jang-Soo Yook, Joon-Yong Cho
PURPOSE: Alzheimer's disease (AD) is classified as a progressive neurological disorder, which not only causes cognitive impairment but also abnormal weight loss, with a reduction of muscle mass related to the accumulation of amyloid-β (Aβ) in skeletal muscle. Thus, we investigated the effect of treadmill exercise on Aβ deposition, and p-AMPK, p-ACC, BDNF, and GLUT4 protein levels the regulation of muscle energy metabolism using an AD mouse. METHODS: At 13 months of age, NSE/PS2m mice (Tg) and control mice (non-Tg) were assigned to non-exercise control (Con) and exercise groups (Exe)...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28673417/neurologic-injuries-in-noncontact-sports
#20
REVIEW
Robert J Marquardt, Andrew Blake Buletko, Andrew Neil Russman
Noncontact sports are associated with a variety of neurologic injuries. Concussion, vascular injury (arterial dissection), and spinal cord trauma may be less common in noncontact sports, but require special attention from the sports neurologist. Complex regional pain disorders, muscle injury from repetitive use, dystonia, heat exposure, and vascular disorders (patent foramen ovale), occur with similar frequency in noncontact and contact sports. Management of athletes with these conditions requires an understanding of the neurologic consequences of these disorders, the risk of injury with return to play, and consideration for the benefits of exercise in health restoration and disease prevention...
August 2017: Neurologic Clinics
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