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Suely Rozenfeld, Fabiola Giordani, Sonia Coelho
OBJECTIVE: To estimate the frequency of and to characterize the adverse drug events at a terciary care hospital. METHODS: A retrospective review was carried out of 128 medical records from a hospital in Rio de Janeiro in 2007, representing 2,092 patients. The instrument used was a list of triggers, such as antidotes, abnormal laboratory analysis results and sudden suspension of treatment, among others. A simple random sample of patients aged 15 and over was extracted...
December 2013: Revista de Saúde Pública
Antonio Rodríguez, Iván Muñoz, José A Perdigón-Melón, José B Carbajo, María J Martínez, Amadeo R Fernández-Alba, Eloy García-Calvo, Roberto Rosal
Wastewater samples from the secondary clarifier of two treatment plants were spiked in the microgram-to-tens-of-microgram per liter range with diuron (herbicide), ibuprofen and diclofenac (anti-inflammatory drugs), sulfamethoxazole and erythromycin (antibiotics), bezafibrate and gemfibrozil (lipid regulators), atenolol (β-blocker), carbamazepine (anti-epileptic), hydrochlorothiazide (diuretic), caffeine (stimulant) and N-acetyl-4-amino-antipiryne, a metabolite of the antipyretic drug dypirone. They were subsequently ozonated in continuous flow using 1...
October 15, 2012: Science of the Total Environment
M Ibáñez, E Gracia-Lor, J V Sancho, F Hernández
Pharmaceuticals are emerging contaminants of increasing concern because of their presence in the aquatic environment and potential to reach drinking-water sources. After human and/or veterinary consumption, pharmaceuticals can be excreted in unchanged form, as the parent compound, and/or as free or conjugated metabolites. Determination of most pharmaceuticals and metabolites in the environment is commonly made by liquid chromatography (LC) coupled to mass spectrometry (MS). LC coupled to tandem MS is the technique of choice nowadays in this field...
August 2012: Journal of Mass Spectrometry: JMS
Keren Ben-Ari, Ilan Goldberg, Idit Shirazi, Iris Amitay, Ma'ayanit Sigler, Sarah Brenner
BACKGROUND: DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a rare but severe drug reaction. OBSERVATIONS: A 27-year-old male with paranoid schizophrenia was hospitalized with all three diagnostic criteria of DRESS syndrome: cutaneous drug eruption, hematological abnormalities (presence of atypical lymphocytes on blood smear) and systemic involvement (generalized lymphadenopathy and hepatitis). On hospitalization the patient exhibited an unusual fever pattern of high temperatures in the morning hours and lower temperatures towards evening...
October 11, 2008: Journal of Dermatological Case Reports
Luiz Eduardo Imbelloni, Eneida Maria Vieira, Fábio Stuchhi Devito, Eliana Marisa Ganem
BACKGROUND AND OBJECTIVES: The number of bilateral total hip arthroplasties (THA) has been increasing every year. Postoperative analgesia by continuous perineural infusion of local anesthetic has been shown favorable results when compared to systemic analgesia. The use of elastomeric pumps has increased patient satisfaction when compared to electronic models. The objective of this report was to describe a case of continuous bilateral posterior lumbar plexus block with an elastomeric infusion pump in a patient submitted to bilateral hip arthroplasty...
March 2011: Revista Brasileira de Anestesiologia
Ricardo Antônio Guimarães Barbosa, Camerine Domingues da Silva, Mary Yumi Takei Torniziello, Luciana Mendes de Olivera Cerri, Maria José Carvalho Carmona, Luiz Marcelo Sá Malbouisson
BACKGROUND AND OBJECTIVES: Ultrasound-guided transrectal prostate biopsy is a reference in the diagnosis of prostate neoplasias. The higher the number of samples, the greater is the pain and discomfort. The objective of this study was to compare three anesthetic techniques in this group of patients. METHODS: Forty-five patients were included in this study. Patients were divided into three groups: 1 - Propofol; 2 - Propofol + Prostatic Plexus Block; 3 - Propofol + Fentanyl...
September 2010: Revista Brasileira de Anestesiologia
Everton Tenório de Souza, Daysianne Pereira de Lira, Aline Cavalcanti de Queiroz, Diogo José Costa da Silva, Anansa Bezerra de Aquino, Eliane A Campessato Mella, Vitor Prates Lorenzo, George Emmanuel C de Miranda, João Xavier de Araújo-Júnior, Maria Célia de Oliveira Chaves, José Maria Barbosa-Filho, Petrônio Filgueiras de Athayde-Filho, Bárbara Viviana de Oliveira Santos, Magna Suzana Alexandre-Moreira
The antinociceptive and anti-inflammatory activity of caulerpin was investigated. This bisindole alkaloid was isolated from the lipoid extract of Caulerpa racemosa and its structure was identified by spectroscopic methods, including IR and NMR techniques. The pharmacological assays used were the writhing and the hot plate tests, the formalin-induced pain, the capsaicin-induced ear edema and the carrageenan-induced peritonitis. Caulerpin was given orally at a concentration of 100 micromol/kg. In the abdominal constriction test caulerpin showed reduction in the acetic acid-induced nociception at 0...
2009: Marine Drugs
Monica Rossi Rodrigues, Franklin Cêspedes Paes, Leonardo Teixeira Domingues Duarte, Luiz Guilherme Nadal Nunes, Verônica Vieira da Costa, Renato Angelo Saraiva
BACKGROUND AND OBJECTIVES: Correction of congenital clubfoot (CCF) is associated with severe postoperative pain. Caudal epidural block associated with general anesthesia is the anesthetic technique used more often in children, but it is limited by the short duration of the postoperative analgesia. Peripheral nerve blocks are associated with a low incidence of complications and prolonged analgesia. The objective of this study was to compare the duration of analgesia in peripheral nerve blocks and caudal block, as well as morphine consumption in the first 24 hours after correction of CCF in children...
November 2009: Revista Brasileira de Anestesiologia
Ricardo Francisco Simoni, Luiz Marciano Cangiani, Antônio Márcio Sanfim Arantes Pereira, Múcio Paranhos Abreu, Luis Henrique Cangiani, Guilherme Zemi
BACKGROUND AND OBJECTIVES: Due to its pharmacokinetic characteristics, remifentanil does not promote residual analgesia in the immediate postoperative period. The objective of this study was to compare the efficacy of methadone and clonidine in the control of postoperative pain of videolaparoscopic surgeries under total intravenous anesthesia with target-controlled remifentanil infusion. METHODS: One hundred and twenty-six patients, ages 18 to 65 years, ASA I and II, of both genders, scheduled for laparoscopic surgeries, participated in this randomized, double- blind, placebo-controlled study...
July 2009: Revista Brasileira de Anestesiologia
Walter Pinto Neto, Adriana Machado Issy, Rioko Kimiko Sakata
BACKGROUND AND OBJECTIVES: Neurological evaluation can be done during cervical plexus block for endarterectomy, which also maintains postoperative analgesia. The objective of this study was to compare the analgesic effects of clonidine associated with bupivacaine to those of bupivacaine in cervical plexus block. METHODS: A randomized double-blind study was undertaken with 30 patients divided in two groups: G1 received 1.5 of 0.375% bupivacaine associated with 150 (1/4)g of clonidine (2 mL), and G2 received 1...
July 2009: Revista Brasileira de Anestesiologia
Fabiano Souza Araújo, Roberto Cardoso Bessa Júnior, Carlos Henrique Viana de Castro, Marcos Guilherme Cunha Cruvinel, Dalton Santos
BACKGROUND AND OBJECTIVES: Steinert disease is the most common muscular dystrophy of the adult. Due to its multisystem characteristic, the perioperative management of these patients is a challenge to the anesthesiologist. The aim of this report was to present a case of hemorrhoidectomy in a patient with muscular dystrophy and to discuss the several anesthetic implications involved. CASE REPORT: A man patient, 58 years old, with Steinert disease, who underwent hemorrhoidectomy...
December 2006: Revista Brasileira de Anestesiologia
Elizabeth Vaz da Silva, Marco Antonio Cardoso de Resende, Alberto Pantoja, Adriana Barrozo Ribeiro Furuguem Carvalho, Alexandre Barbosa da Silva, Fabrício Azevedo Cardoso
BACKGROUND AND OBJECTIVES: Very often, neurological injuries diagnosed postoperatively are attributed to the anesthesia, but they can also be secondary to the surgery itself. The aim of this report was to present the case of a patient who underwent a pelvic surgery and developed lumbar plexopathy, and to discuss the possible causes. CASE REPORT: A woman patient, 38 years old, 58 kg, 1.63 m, physical status ASA I, was admitted to undergo a total abdominal hysterectomy for treatment of uterine leiomyomatosis...
December 2006: Revista Brasileira de Anestesiologia
Fabiano Timbó Barbosa, Rafael Martins da Cunha, Anita Perpétua Carvalho Rocha, Hélio José Leal Silva Júnior
BACKGROUND AND OBJECTIVES: The loss of resistance to air to identify the epidural space is widely used. However, the accidental perforation of the dura mater is one of the possible complications of this procedure, with an estimated incidence between 1% and 2%. The objective of this report was to describe the case of a patient with intraventricular pneumocephalus after the accidental perforation of the dura mater using the loss of resistance with air technique. CASE REPORT: Female patient, 26 years old, 75 kg, 1...
October 2006: Revista Brasileira de Anestesiologia
João Batista Santos Garcia, Antônio M Alencar Júnior, Carlos Eduardo Claro dos Santos
BACKGROUND AND OBJECTIVES: The analgesic effect of intraperitoneal administration of local anesthetics after laparoscopic cholecystectomy is a controversial issue, and the results described vary from considerable pain relief to little reduction in pain. The objective of this study was to evaluate the efficacy of the intraperitoneal administration of 50% enantiomeric excess bupivacaine (S75-R25) for the postoperative pain relief of laparoscopic cholecystectomy. METHODS: A randomized, double blind, placebo controlled study was conducted with 40 patients undergoing laparoscopic cholecystectomy, who were divided in two groups: GI (n = 20) received 80 mL of intraperitoneal 0,125% S75-R25 bupivacaine at the end of the procedure; and GII (n = 20) received 80 mL of intraperitoneal normal saline...
August 2007: Revista Brasileira de Anestesiologia
Ricardo Francisco Simoni, Antônio Márcio Sanfim Arantes Pereira, Renato dos Santos Borega, Daniel Caldeira Pereira Simões
BACKGROUND AND OBJECTIVES: Continuous infusion (CI) of remifentanil is common in total intravenous anesthesia. On the other hand, CI of sufentanil for short/medium-term surgeries has not been widely used. The objective of this study was to compare two techniques of total intravenous anesthesia, using CI of remifentanil or sufentanil, regarding their intraoperative behavior and characteristics of recovery of patients undergoing videolaparoscopic surgeries. METHODS: Sixty patients, equally divided in 2 groups (RG, and SG), participated in this study...
May 2008: Revista Brasileira de Anestesiologia
William Kondo, Rafael W Noda, Anibal W Branco, Marlon Rangel, Alcides J Branco Filho
BACKGROUND: Tubal sterilization is one of the most widely used options for female contraception. It can be performed by laparotomy, minilaparotomy, colpotomy, laparoscopy, and hysteroscopy. In this paper, we report the use of the transvaginal endoscopic approach to perform tubal ligation. CASE: The access to the abdomen was obtained by a 1.5-cm colpotomy. The flexible endoscope was introduced into the peritoneal cavity, and carbon dioxide was instilled to get the pneumoperitoneum...
February 2009: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Luis E Morillo, Fernando Alarcon, Nayesca Aranaga, Sara Aulet, Evelina Chapman, Lucien Conterno, Edmundo Estevez, Felipe Garcia-Pedroza, Juanita Garrido, Miguel Macias-Islas, Paulo Monzillo, Lilia Nunez, Noel Plascencia, Carlos Rodriguez, Yuri Takeuchi
OBJECTIVE: The objective of this study was to document the clinical characteristics of migraine and patterns of medication use in residents > or =15 years old in 12 Latin American urban communities. BACKGROUND: Few large-scale population studies have established the symptoms and disability associated with migraine with or without aura in Latin American urban communities or the pattern of medication use in these regions. METHODS: In this study, subjects in 12 urban communities, from 6 Latin American countries, were surveyed with a validated face-to-face interview questionnaire based on International Headache Society criteria for migraine...
February 2005: Headache
Carlos Navarro Núñez, Alfredo Aquino Adrián, Clemente Vásquez Jiménez, Rafael García Martínez
We studied 40 patients undergoing minor gynaecological surgery, anaesthetized in random order with sevoflurane-nitrous oxide or thiopental-fentanyl. Operating conditions, pain, recovery and postoperative nausea and vomiting were assessed. For postoperative analgesia, all patients were given dypiron 1 g intravenous at the end of anaesthesia. Patients and gynaecologists were equally satisfied with both anaesthetic techniques. The time of surgery were higher in patients given sevoflurane, (7 versus 5 minutes) this women had recovery faster (17 versus 72 minutes) became orientated, followed orders (11 versus 19 minutes) and were able to walk (17 versus 60 minutes) significantly (p < 0...
June 2003: Ginecología y Obstetricia de México
Sinforiano J Posadas, María J Torres, Cristobalina Mayorga, Carlos Juarez, Miguel Blanca
Drugs can induce IgE mediated or T cell dependent immunological reactions. T cell dependent reactions are poorly understood, although T lymphocytes have been proposed as a protagonist in a number of non-immediate immunological reactions (NIR). The objective was to study in vivo different regulatory and proinflammatory cytokines and cytotoxic markers in patients with NIR to drugs. Twenty patients with NIR after drug intake were classified into two groups: Group A (severe), Stevens-Johnson syndrome and toxic epidermal necrolysis; and Group B (mild), maculopapular exanthema and desquamative exanthema...
September 2002: Blood Cells, Molecules & Diseases
V S Frutuoso, M R Gurjão, R S Cordeiro, M A Martins
An aqueous crude extract and a polar fraction derived from this extract were prepared from leaves of Vernonia condensata Baker and assessed in standard rodent models of algesia and ulcerogenesis. Oral pretreatment with the lyophilized crude extract (200 mg/kg) significantly reduced mouse writhing counts caused by the i.p. injection of increasing concentrations (0.6-1.2%) of acetic acid (0.1 ml/10 g). In doses ranging from 50 to 400 mg/kg, the crude extract inhibited dose-dependently mouse writhing induced by acetic acid (0...
February 1994: Planta Medica
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