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Canine behavior

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https://www.readbyqxmd.com/read/29128350/biomechanical-behavior-of-adhesive-cement-layer-and-periodontal-tissues-on-the-restored-teeth-with-zirconia-rbfdps-using-three-kinds-of-framework-design-3d-fea-study
#1
Ayana Uraba, Reina Nemoto, Kosuke Nozaki, Tasuku Inagaki, Satoshi Omori, Hiroyuki Miura
PURPOSE: To investigate stress and strain concentrations on resin-bonded fixed dental prostheses (RBFDPs) frameworks of different design using finite element analysis. METHODS: A human dry skull was scanned and models were produced using three-dimensional printer. After abutment preparation, three frameworks, including a three-unit RBFDP, and two-unit cantilevered RBFDPs using #21 and #23 for the abutment tooth, were fabricated. Scanned data were subtracted to define boundary of each structure...
November 8, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29126633/mechanical-behavior-of-endodontically-restored-canine-teeth-effects-of-ferrule-post-material-and-shape
#2
Pietro Ausiello, Stefano Ciaramella, Massimo Martorelli, Antonio Lanzotti, Fernando Zarone, David C Watts, Antonio Gloria
OBJECTIVE: To assess the effect of a ferrule design with specific post material-shape combinations on the mechanical behavior of post-restored canine teeth. METHODS: Micro-CT scan images of an intact canine were used to create a 3-D tessellated CAD model, from which the shapes of dentin, pulp and enamel were obtained and geometric models of post-endodontically restored teeth were created. Two types of 15mm post were evaluated: a quartz fiber post with conical-tapered shape, and a carbon (C) fiber post with conical-cylindrical shape...
November 7, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29124059/evaluation-of-three-hydration-strategies-in-detection-dogs-working-in-a-hot-environment
#3
Cynthia M Otto, Elizabeth Hare, Jess L Nord, Shannon M Palermo, Kathleen M Kelsey, Tracy A Darling, Kasey Schmidt, Destiny Coleman
Physical activity in hot environments can increase the risk of heat stress or heat stroke in dogs. Heat tolerance is influenced by acclimatization to the environment, physical fitness, and hydration state. Three common strategies to promote hydration in working dogs are free access to water (W), oral electrolyte solutions (OESs), and administration of subcutaneous fluids (SQs). None of these methods have been compared for safety or efficacy in a working environment. In a cross-over design, seven vehicle-screening canines were randomly assigned to each of the three hydration strategies during working shifts at the Sarita, TX checkpoint...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29107993/nanoencapsulated-capsaicin-changes-migration-behavior-and-morphology-of-madin-darby-canine-kidney-cell-monolayers
#4
Mathias Kaiser, Luisa Pohl, Steffi Ketelhut, Lena Kastl, Christian Gorzelanny, Martin Götte, Jürgen Schnekenburger, Francisco M Goycoolea, Björn Kemper
We have developed a drug delivery nanosystem based on chitosan and capsaicin. Both substances have a wide range of biological activities. We investigated the nanosystem's influence on migration and morphology of Madin Darby canine kidney (MDCK-C7) epithelial cells in comparison to the capsaicin-free nanoformulation, free capsaicin, and control cells. For minimally-invasive quantification of cell migration, we applied label-free digital holographic microscopy (DHM) and single-cell tracking. Moreover, quantitative DHM phase images were used as novel stain-free assay to quantify the temporal course of global cellular morphology changes in confluent cell layers...
2017: PloS One
https://www.readbyqxmd.com/read/29105787/kinematic-behavior-of-a-novel-pedicle-screw-rod-fixation-system-for-the-canine-lumbosacral-joint
#5
Claudia Zindl, Alan S Litsky, Noel Fitzpatrick, Matthew J Allen
OBJECTIVE: To determine the biomechanical behavior of a novel distraction-stabilization system, consisting of an intervertebral distraction bolt, polyaxial screws, and connecting rods, in the canine lumbosacral spine. STUDY DESIGN: Biomechanical study. SAMPLE POPULATION: Cadaveric canine lumbosacral spines (L4-Cd3) (N = 8). METHODS: Cadaveric lumbosacral spines were harvested, stripped of musculature, mounted on a 4-point bending jig, and tested in extension, flexion, and lateral bending using nondestructive compressive axial loads (0-150 N)...
November 6, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29073243/rna-seq-transcriptome-analysis-of-formalin-fixed-paraffin-embedded-canine-meningioma
#6
Jennifer K Grenier, Polly A Foureman, Erica A Sloma, Andrew D Miller
Meningiomas are the most commonly reported primary intracranial tumor in dogs and humans and between the two species there are similarities in histology and biologic behavior. Due to these similarities, dogs have been proposed as models for meningioma pathobiology. However, little is known about specific pathways and individual genes that are involved in the development and progression of canine meningioma. In addition, studies are lacking that utilize RNAseq to characterize gene expression in clinical cases of canine meningioma...
2017: PloS One
https://www.readbyqxmd.com/read/29068711/defaming-rover-error-based-latent-rhetoric-in-the-medical-literature-on-dog-bites
#7
Arnold Arluke, Donald Cleary, Gary Patronek, Janis Bradley
This article examines the accuracy and rhetoric of reports by human health care professionals concerning dog bite injuries published in the peer-reviewed medical literature, with respect to nonclinical issues, such as dog behavior. A qualitative content analysis examined 156 publications between 1966 and 2015 identified by terms such as "dog bite" or "dangerous dogs." The analysis revealed misinformation about human-canine interactions, the significance of breed and breed characteristics, and the frequency of dog bite-related injuries...
October 25, 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/29063312/canine-invasive-mammary-carcinomas-as-models-of-human-breast-cancer-part-2-immunophenotypes-and-prognostic-significance
#8
Jérôme Abadie, Frédérique Nguyen, Delphine Loussouarn, Laura Peña, Adelina Gama, Natascha Rieder, Anton Belousov, Ingrid Bemelmans, Laëtitia Jaillardon, Catherine Ibisch, Mario Campone
PURPOSE: Relevant animal models of human breast cancer are currently needed, especially for the aggressive triple-negative breast cancer subtype. Recent studies and our results (Part 1) indicate that spontaneous canine invasive mammary carcinomas (CMCs) resemble human breast cancer by clinics and pathology as well as behavior and prognostic indicators. We hypothesized that the current molecular classifications of human breast cancer, used for therapeutic decision, could be relevant to dogs...
October 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29056700/how-behavioral-changes-can-indicate-serious-cerebral-pathology-a-case-report-of-concomitant-olfactory-neuroblastoma-and-distemper-virus-encephalitis-in-a-swiss-shepherd-dog
#9
Dario Candini, Ilaria Biasato, Paulo Ricardo Dell'Armelina Rocha, Elena Grego, Maria Teresa Capucchio, Cristina Vercelli
Behavioral alterations in dogs are not easy to understand and cure. The situation is more difficult when an encephalitis due to Canine Distemper Virus (CDV) and a concomitant olfactory neuroblastoma are present. This case report deals with the story of a 5-year-old Swiss shepherd dog with behavioral changes, seizures, epistaxis and ataxia. Following clinical and laboratory exams, a suspected diagnosis of CDV infection was hypothesized, and a therapy based on Ω-interferon was administered. Every supporting therapy failed and the worsening of the clinical conditions led to the euthanasia of the patient...
August 28, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29043250/canine-food-preference-assessment-of-animal-and-vegetable-ingredient-based-diets-using-single-pan-tests-and-behavioral-observation
#10
Meghan C Callon, Cara Cargo-Froom, Trevor J DeVries, Anna K Shoveller
Knowledge of canine food selection is critical for both the pet food industry and dog owners, since owners want quality foods that are palatable, while fulfilling their pet's nutritional requirements. There are two common methods for assessing canine food preference: the two-pan test and the one-pan test. Neither test fully accounts for the complexity of the canine feeding experience nor do they provide applicable representations of canine feeding behavior in the home. The objectives of this study were to (1) determine whether dogs display a preference for animal ingredient-based diets when compared with vegetable ingredient-based diets and (2) examine whether dogs experience neophobia when presented with a novel diet...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29029635/individual-signatures-and-environmental-factors-shape-skin-microbiota-in-healthy-dogs
#11
Anna Cuscó, Janelle M Belanger, Liza Gershony, Alma Islas-Trejo, Kerinne Levy, Juan F Medrano, Armand Sánchez, Anita M Oberbauer, Olga Francino
BACKGROUND: The individual, together with its environment, has been reported as the main force driving composition and structure of skin microbiota in healthy dogs. Therefore, one of the major concerns when analyzing canine skin microbiota is the likely influence of the environment. Despite the dense fur covering, certain skin diseases exhibit differential prevalence among skin sites, dog breeds, and individuals. RESULTS: We have characterized the normal variability of dog skin microbiota in a well-controlled cohort of a large number of Golden-Labrador Retriever crossed dogs (N = 35) with similar ages, related genetic background, and a shared environment...
October 13, 2017: Microbiome
https://www.readbyqxmd.com/read/29020057/high-dose-teriparatide-rpth1-34-therapy-increases-callus-volume-and-enhances-radiographic-healing-at-8-weeks-in-a-massive-canine-femoral-allograft-model
#12
Kohei Nishitani, Zachary Mietus, Christopher A Beck, Hiromu Ito, Shuichi Matsuda, Hani A Awad, Nicole Ehrhart, Edward M Schwarz
Small animal studies have demonstrated significant high-dose recombinant parathyroid hormone1-34 (rPTH1-34) effects on intercalary allograft healing. Towards a human adjuvant therapy to decrease non-unions, we evaluated rPTH1-34 safety and efficacy in a clinically relevant canine femoral allograft model. Adult female mongrel hounds (n = 20) received a 5cm mid-diaphyseal osteotomy reconstructed with a plated allograft, and were randomized to: 1) Placebo (n = 5; daily saline), 2) Continuous rPTH1-34 (n = 7; 5 μg/kg/day s...
2017: PloS One
https://www.readbyqxmd.com/read/28969915/accuracy-of-digitally-fabricated-trial-dentures
#13
Timea Wimmer, Marlis Eichberger, Nina Lümkemann, Bogna Stawarczyk
STATEMENT OF PROBLEM: Information about the accuracy of digital computer-aided design and computer-aided manufacturing (CAD-CAM) complete dentures is scarce. PURPOSE: The purpose of this in vitro study was to assess the reproducibility of the occlusion of wax dentures fabricated with digital steps and the contraction behavior of wax trial dentures processed with combined conventional-digital steps. These were compared with those fabricated completely conventionally in terms of storage duration...
September 29, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28955181/canine-and-feline-models-of-human-genetic-diseases-and-their-contributions-to-advancing-clinical-therapies%C3%A2
#14
REVIEW
Brittney L Gurda, Allison M Bradbury, Charles H Vite
For many lethal or debilitating genetic disorders in patients there are no satisfactory therapies. Several barriers exist that hinder the developments of effective therapies including the limited availability of clinically relevant animal models that faithfully recapitulate human genetic disease. In 1974, the Referral Center for Animal Models of Human Genetic Disease (RCAM) was established by Dr. Donald F. Patterson and continued by Dr. Mark E. Haskins at the University of Pennsylvania with the mission to discover, understand, treat, and maintain breeding colonies of naturally occurring hereditary disorders in dogs and cats that are orthologous to those found in human patients...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28941247/wear-testing-of-a-canine-hip-resurfacing-implant-that-uses-highly-cross-linked-polyethylene
#15
Kevin J Warburton, John B Everingham, Jillian L Helms, Andrew J Kazanovicz, Katherine A Hollar, Jeff D Brourman, Steven M Fox, Trevor J Lujan
Hip resurfacing offers advantages for young, active patients afflicted with hip osteoarthritis and may also be a beneficial treatment for adult canines. Conventional hip resurfacing uses metal-on-metal bearings to preserve bone stock, but it may be feasible to use metal-on-polyethylene bearings to reduce metal wear debris while still preserving bone. This study characterized the short-term wear behavior of a novel hip resurfacing implant for canines that uses a 1.5 mm thick liner of highly cross-linked polyethylene in the acetabular component...
September 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28939315/revisiting-size-and-scaling-in-the-anthropoid-temporomandibular-joint
#16
Claire E Terhune
Masticatory morphology in primates is likely under strong selective pressure to maximize feeding efficiency while simultaneously minimizing the occurrence of injury or pathology. As a result, masticatory shape, including aspects of temporomandibular joint (TMJ) morphology, varies widely across primates in relation to feeding behavior and body size. This study examines patterns of allometry in the TMJ of anthropoid primates, with the specific goal of evaluating how allometric patterns may reflect variation in loading and/or range of motion at this joint...
August 18, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28912427/dna-methylation-profiling-reveals-common-signatures-of-tumorigenesis-and-defines-epigenetic-prognostic-subtypes-of-canine-diffuse-large-b-cell-lymphoma
#17
Serena Ferraresso, Arianna Aricò, Tiziana Sanavia, Silvia Da Ros, Massimo Milan, Luciano Cascione, Stefano Comazzi, Valeria Martini, Mery Giantin, Barbara Di Camillo, Sandro Mazzariol, Diana Giannuzzi, Laura Marconato, Luca Aresu
Epigenetic deregulation is a hallmark of cancer characterized by frequent acquisition of new DNA methylation in CpG islands. To gain insight into the methylation changes of canine DLBCL, we investigated the DNA methylome in primary DLBCLs in comparison with control lymph nodes by genome-wide CpG microarray. We identified 1,194 target loci showing different methylation levels in tumors compared with controls. The hypermethylated CpG loci included promoter, 5'-UTRs, upstream and exonic regions. Interestingly, targets of polycomb repressive complex in stem cells were mostly affected suggesting that DLBCL shares a stem cell-like epigenetic pattern...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879893/a-novel-swine-model-of-subarachnoid-hemorrhage-induced-cerebral-vasospasm
#18
Zion Zibly, Lory Fein, Mayur Sharma, Yaron Assaf, Anton Wohl, Sagi Harnof
OBJECTIVE: One of the most serious complications following subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI) secondary to symptomatic vasospasm. An animal model mimicking post SAH vasospasm is essential for enabling the translation of newer technologies from the conceptual phase to animal studies, and eventually to clinical trials. Various animal models of DCI following SAH have been reported, with canine models being the most common. Due to the similarity of the swine cardiovascular system and its dimensions to the human's system, the main objective of this study was to establish a consistent and quantitatively representative model of SAH-induced vasospasm in swine...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28834400/cryopreservation-of-canine-cardiosphere-derived-cells-implications-for-clinical-application
#19
Luke C Dutton, Sophie A V Church, Hannah Hodgkiss-Geere, Brian Catchpole, Anthony Huggins, Jayesh Dudhia, David J Connolly
The clinical application of cardiosphere-derived cells (CDCs) to treat cardiac disease has gained increasing interest over the past decade. Recent clinical trials confirm their regenerative capabilities, although much remains to be elucidated about their basic biology. To develop this new treatment modality, in a cost effective and standardized workflow, necessitates the creation of cryopreserved cell lines to facilitate access for cardiac patients requiring urgent therapy. Cryopreservation may however lead to alterations in cell behavior and potency...
August 22, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28822004/in-vitro-validation-of-the-hippo-pathway-as-a-pharmacological-target-for-canine-mammary-gland-tumors
#20
Samantha Guillemette, Charlène Rico, Philippe Godin, Derek Boerboom, Marilène Paquet
Canine mammary tumors (CMTs) are the most common neoplasms in intact female dogs. Some clinical and molecular similarities between certain CMT subtypes and breast cancer make them a potential model for the study of the human disease. As misregulated Hippo signaling is thought to play an important role in breast cancer development and also occurs in CMTs, we sought to determine if Hippo represents a valid pharmacological target for the treatment of CMTs. Six CMT cell lines were assessed for their expression of the Hippo pathway effectors YAP and TAZ and for their sensitivity to verteporfin, an inhibitor of YAP-mediated transcriptional coactivation...
August 18, 2017: Journal of Mammary Gland Biology and Neoplasia
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