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Canine behavior

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https://www.readbyqxmd.com/read/28724487/effect-of-wearing-a-telemetry-jacket-on-behavioral-and-physiologic-parameters-of-dogs-in-the-open-field-test
#1
Richard E Fish, Melanie L Foster, Margaret E Gruen, Barbara L Sherman, Davidc C Dorman
Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologic measurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and other parameters has not been evaluated. This pilot study assessed the effect of a telemetry vest on behavioral and physiologic responses to an environmental stressor, the sounds of a thunderstorm, in Labrador retrievers. Dogs were assigned to one of 2 experimental groups (Vest and No-Vest, n = 8 dogs per group) by using a matched pairs design, with a previously determined, sound-associated anxiety score as the blocking variable...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28714585/mathematical-model-of-collective-cell-migrations-based-on-cell-polarity
#2
Masakazu Akiyama, Takamichi Sushida, Sumire Ishida, Hisashi Haga
Individual cells migrate toward the direction of the cell polarity generated by interior or exterior factors. Under situations without guides such as chemoattractants, they migrate randomly. On the other hand, it has been observed that cell groups lead to systematic collective cell migrations. For example, Dictyostelium discoideum and Madin-Darby canine kidney (epithelial) cells exhibit typical collective cell migration patterns such as uniformly directional migration and rotational migration. In particular, it has been suggested from experimental investigations that rotational migrations are intimately related to morphogenesis of organs and tissues in several species...
July 17, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28683102/identification-of-prognostic-collagen-signatures-and-potential-therapeutic-stromal-targets-in-canine-mammary-gland-carcinoma
#3
Ashley Case, Becky K Brisson, Amy C Durham, Suzanne Rosen, James Monslow, Elizabeth Buza, Pascale Salah, Julie Gillem, Gordon Ruthel, Sridhar Veluvolu, Veronica Kristiansen, Ellen Puré, Dorothy C Brown, Karin U Sørenmo, Susan W Volk
Increasing evidence indicates that the tumor microenvironment plays a critical role in regulating the biologic behavior of breast cancer. In veterinary oncology, there is a need for improved prognostic markers to accurately identify dogs at risk for local and distant (metastatic) recurrence of mammary gland carcinoma and therefore would benefit from adjuvant therapy. Collagen density and fiber organization have been shown to regulate tumor progression in both mouse and human mammary tumors, with certain collagen signatures predicting poor outcomes in women with breast cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28674014/e-cadherin-and-lgn-align-epithelial-cell-divisions-with-tissue-tension-independently-of-cell-shape
#4
Kevin C Hart, Jiongyi Tan, Kathleen A Siemers, Joo Yong Sim, Beth L Pruitt, W James Nelson, Martijn Gloerich
Tissue morphogenesis requires the coordinated regulation of cellular behavior, which includes the orientation of cell division that defines the position of daughter cells in the tissue. Cell division orientation is instructed by biochemical and mechanical signals from the local tissue environment, but how those signals control mitotic spindle orientation is not fully understood. Here, we tested how mechanical tension across an epithelial monolayer is sensed to orient cell divisions. Tension across Madin-Darby canine kidney cell monolayers was increased by a low level of uniaxial stretch, which oriented cell divisions with the stretch axis irrespective of the orientation of the cell long axis...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28660382/epidemiology-behavior-of-leptospirosis-in-ci%C3%A3-naga-de-oro-c%C3%A3-rdoba-colombia
#5
C Ensuncho-Hoyos, V Rodríguez-Rodríguez, A Pérez-Doria, O Vergara, A Calderón-Rangel
The purpose of this study was to determine the epidemiology of leptospirosis in rural areas of Ciénaga de Oro, Córdoba, Colombia, a convenience sampling was carried out on 13 farms. The sample size was 325 reproductive age cows, 11 canine samples, and 20 humans. The samples were subjected to MAT analysis with 11 serogroups of Leptospira interrogans sensu lato. Once the MAT results were received, urine samples were collected from 78 cows, along with 39 water samples, for bacteriological cultures and PCR for the 16S rRNA gene in L...
June 28, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28631549/comparison-of-histological-and-proliferation-features-of-canine-oral-squamous-cell-carcinoma-based-on-intraoral-location-36-cases
#6
Lisa A Mestrinho, Hugo Pissarra, Sandra Carvalho, Maria C Peleteiro, Jerzy Gawor, Maria M R E Niza
Grade and labeling indices for immunohistochemical tumor proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) were evaluated in 36 cases of canine oral squamous cell carcinoma (OSCC) based upon intraoral location. Grade was significantly associated with location ( P = .035). Grade II tumors were most frequently diagnosed. Grade I tumors were identified in the gingiva and the buccal mucosa, and grade III tumors were seen in the gingiva and the tonsillar region. Animals with tumors arising from the tonsils and of the tongue tended to be older ( P = ...
June 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28580034/the-effect-of-co0-2mn0-8fe2o4-ferrite-nanoparticles-on-the-c2-canine-mastocytoma-cell-line-and-adipose-derived-mesenchymal-stromal-stem-cells-ascs-cultured-under-a-static-magnetic-field-possible-implications-in-the-treatment-of-dog-mastocytoma
#7
K Marycz, M Marędziak, D Lewandowski, E Zachanowicz, A Zięcina, R J Wiglusz, R Pązik
Cobalt manganese ferrite nanoparticles have application potential in the biomedical field, however there is limited information concerning the biological response. The aim of this work was to investigate the cytotoxic potential of cobalt-manganese ferrite nanoparticles in canine mastocytoma tumor cells (C2) and adipose-derived mesenchymal stromal stem cells (ASCs) cultured under a static magnetic field (MF). In this study, we investigated the viability and proliferation rate of ASC and C2 cells cultured with Co0...
2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/28571614/canis-familiaris-as-a-model-for-non-invasive-comparative-neuroscience
#8
REVIEW
Nóra Bunford, Attila Andics, Anna Kis, Ádám Miklósi, Márta Gácsi
There is an ongoing need to improve animal models for investigating human behavior and its biological underpinnings. The domestic dog (Canis familiaris) is a promising model in cognitive neuroscience. However, before it can contribute to advances in this field in a comparative, reliable, and valid manner, several methodological issues warrant attention. We review recent non-invasive canine neuroscience studies, primarily focusing on (i) variability among dogs and between dogs and humans in cranial characteristics, and (ii) generalizability across dog and dog-human studies...
May 29, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28534468/effect-of-wearing-a-telemetry-jacket-on-behavioral-and-physiologic-parameters-of-dogs-in-the-open%C3%A2-field-test
#9
Richard E Fish, Melanie L Foster, Margaret E Gruen, Barbara L Sherman, David C Dorman
Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologicmeasurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and otherparameters has not been evaluated. This pilot study assessed the effect of a telemetry vest on behavioral and physiologic responses to an environmental stressor, the sounds of a thunderstorm, in Labrador retrievers. Dogs were assigned to one of 2 experimental groups (Vest and No-Vest, n = 8 dogs per group) by using a matched pairs design, with a previously determined,sound-associated anxiety score as the blocking variable...
May 22, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28503035/current-trends-in-canine-problem-solving-and-cognition
#10
Ádám Miklósi, Enikő Kubinyi
Dogs have occupied a central place in modern comparative cognition, partly because of their specific past and present relationship with humans. Over the years, we have gained insights about the functioning of the dog's mind, which has helped us to understand how dogs' problem-solving abilities differ from those present in related species such as the wolf. Novel methodologies are also emerging that allow for the study of neural and genetic mechanisms that control mental functions. By providing an overview from an ethological perspective, we call for greater integration of the field and a better understanding of natural dog behavior as a way to generate scientific hypotheses...
October 1, 2016: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/28501556/behavioral-and-physiological-reactions-in-dogs-to-a-veterinary-examination-owner-dog-interactions-improve-canine-well-being
#11
Erika Csoltova, Michaël Martineau, Alain Boissy, Caroline Gilbert
In order to improve well-being of dogs during veterinary visits, we aimed to investigate the effect of human social interactions on behavior and physiology during routine examination. Firstly, we assessed the impact of a standardized veterinary examination on behavioral and physiological indicators of stress in dogs. Secondly, we examined whether the owner's tactile and verbal interactions with the dog influenced behavioral and physiological stress-associated parameters. A randomized within-subjects crossover design was used to examine behavior (n=33), rectal temperature (n=33), heart rate (HR) (n=18), maximal ocular surface temperature (max OST) (n=13) and salivary cortisol concentrations (n=10) in healthy privately owned pet dogs...
August 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28494924/loss-of-cd45-cell-surface-expression-in-canine-t-zone-lymphoma-results-from-reduced-gene-expression
#12
V Martini, M Cozzi, A Aricò, G Dalla Rovere, A Poggi, F Albonico, M Mortarino, E Ciusani, L Aresu, S Comazzi
Canine T-zone lymphoma (TZL) is a peculiar lymphoma subtype characterized by an indolent clinical course and aberrant CD45-negative phenotype, commonly recognized by flow cytometry (FC). Recent studies have described clinical presentation and behavior, but to date the mechanisms behind the loss of CD45 protein expression have never been investigated. The aims of this study were: 1) to confirm the absence of CD45 in canine TZL via the concomitant use of FC and immunohistochemistry with two different sources of antibody; and 2) to investigate the amount of CD45 transcript and the presence of CD45 gene in the neoplastic cells of dogs affected by TZL...
May 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28494700/invasive-front-grading-and-epithelial-mesenchymal-transition-in-canine-oral-and-cutaneous-squamous-cell-carcinomas
#13
E Nagamine, K Hirayama, K Matsuda, M Okamoto, T Ohmachi, K Uchida, T Kadosawa, H Taniyama
Oral and cutaneous tissues are the most frequent origin in canine squamous cell carcinoma (SSC). In SCC, changes in adhesion molecule expression and transition from epithelial to mesenchymal phenotype are thought to be important in development of invasive behavior of neoplastic cells at the leading front of the tumor. We therefore investigated histological invasive front grading and epithelial-mesenchymal transition (EMT) in both oral SCCs and cutaneous SCCs. EMT was assessed by evaluating immunohistochemical expression of E-cadherin, β-catenin, desmoglein, vimentin, and N-cadherin...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28491015/protocols-for-visually-guided-navigation-assessment-of-efficacy-of-retina-directed-cell-or-gene-therapy-in-canines
#14
Puya Aravand, Pavitra S Ramachandran, Ivan Schpylchak, Nicholas T Phelps, Sergei Nikonov, Jean Bennett
There has been marked progress in recent years in developing gene delivery approaches for the treatment of inherited blinding diseases. Many of the proof-of-concept studies have utilized rodent models of retinal degeneration. In those models, tests of visual function include a modified water maze swim test, optokinetic nystagmus, and light-dark activity assays. Test paradigms used in rodents can be difficult to replicate in large animals due to their size and awareness of non-visual aspects of the test system...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28487862/naturally-occurring-canine-invasive-urinary-bladder-cancer-a-complementary-animal-model-to-improve-the-success-rate-in-human-clinical-trials-of-new-cancer-drugs
#15
REVIEW
Christopher M Fulkerson, Deepika Dhawan, Timothy L Ratliff, Noah M Hahn, Deborah W Knapp
Genomic analyses are defining numerous new targets for cancer therapy. Therapies aimed at specific genetic and epigenetic targets in cancer cells as well as expanded development of immunotherapies are placing increased demands on animal models. Traditional experimental models do not possess the collective features (cancer heterogeneity, molecular complexity, invasion, metastasis, and immune cell response) critical to predict success or failure of emerging therapies in humans. There is growing evidence, however, that dogs with specific forms of naturally occurring cancer can serve as highly relevant animal models to complement traditional models...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28475997/invasive-micropapillary-carcinoma-of-the-mammary-gland-in-humans-and-canines-clinicopathological-immunophenotypical-and-survival-approaches
#16
Conrado de Oliveira Gamba, Dirceu Scaratti, Victor Piana de Andrade, Alessandra Estrela-Lima, Enio Ferreira, Geovanni Dantas Cassali
Invasive micropapillary carcinoma (IMPC) is a breast cancer with a proclivity for lymph node metastasis that affects women. In canines, this carcinoma has only recently been reported and appears to have similar histological aspects as its human counterpart. Thus, the aim of the present study was to compare clinicopathological, immunohistochemical and prognostic characteristics of mammary IMPC between humans and canines. In canines, regional metastasis was more frequently observed. Histopathologically, humans and canines predominantly showed a moderate histological grade...
April 20, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28451594/novel-biomarker-for-evaluating-ischemic-stress-using-an-electrogram-derived-phase-space
#17
Wilson W Good, Burak Erem, Jaume Coll-Font, Dana H Brooks, Rob S MacLeod
The underlying pathophysiology of ischemia is poorly understood, resulting in unreliable clinical diagnosis of this disease. This limited knowledge of underlying mechanisms suggested a data driven approach, which seeks to identify patterns in the ECG data that can be linked statistically to underlying behavior and conditions of ischemic tissue. Previous studies have suggested that an approach known as Laplacian eigenmaps (LE) can identify trajectories, or manifolds, that are sensitive to different spatiotemporal consequences of ischemic stress, and thus serve as potential clinically relevant biomarkers...
September 2016: Computing in Cardiology
https://www.readbyqxmd.com/read/28446072/the-influence-of-force-direction-on-the-fracture-pattern-and-fracture-resistance-of-canine-teeth-in-dogs
#18
Stephanie Goldschmidt, Catherine Zimmerman, Caitlyn Collins, Scott Hetzel, Heidi-Lynn Ploeg, Jason W Soukup
Biomechanical studies of the elongated canine tooth of animals are few, and thus our understanding of mechanical and physical properties of animal teeth is limited. The objective of the present study was to evaluate the influence of force direction on fracture resistance and fracture pattern of canine teeth in an ex vivo dog cadaver model. Forty-five extracted canine teeth from laboratory beagle dogs were standardized by hard tissue volume and randomly distributed among 3 force direction groups. The teeth were secured within a universal testing machine and a load was applied at different directions based on testing group...
March 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28443051/social-behavior-of-pet-dogs-is-associated-with-peripheral-oxtr-methylation
#19
Giulia Cimarelli, Zsófia Virányi, Borbála Turcsán, Zsolt Rónai, Mária Sasvári-Székely, Zsófia Bánlaki
Oxytocin is a key modulator of emotional processing and social cognitive function. In line with this, polymorphisms of genes involved in oxytocin signaling, like the oxytocin receptor (OXTR) gene, are known to influence social behavior in various species. However, to date, no study has investigated environmental factors possibly influencing the epigenetic variation of the OXTR gene and its behavioral effects in dogs. Pet dogs form individualized and strong relationships with their owners who are central figures in the social environment of their dogs and therefore might influence the methylation levels of their OXTR gene...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28421298/dog-rivalry-impacts-following-behavior-in-a-decision-making-task-involving-food
#20
Christy L Hoffman, Malini Suchak
Dogs learn a great deal from humans and other dogs. Previous studies of socially influenced learning between dogs have typically used a highly trained demonstrator dog who is unfamiliar to the observer. Because of this, it is unknown how dynamics between familiar dogs may influence their likelihood of learning from each other. In this study, we tested dogs living together in two-dog households on whether individual dogs' rivalry scores were associated with performance on a local enhancement task. Specifically, we wanted to know whether dog rivalry impacted whether an observer dog would approach a plate from which a demonstrator dog had eaten all available food, or whether the observer dog would approach the adjacent plate that still contained food...
July 2017: Animal Cognition
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