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https://www.readbyqxmd.com/read/29759829/acute-and-3-month-performance-of-a-communicating-leadless-antitachycardia-pacemaker-and-subcutaneous-implantable-defibrillator
#1
Fleur V Y Tjong, Tom F Brouwer, Brendan Koop, Brian Soltis, Allan Shuros, Brian Schmidt, Bryan Swackhamer, Anne-Floor E B Quast, Arthur A M Wilde, Martin C Burke, Reinoud E Knops
OBJECTIVES: The primary objective was to assess the acute and 3-month performance of the modular antitachycardia pacing (ATP)-enabled leadless pacemaker (LP) and subcutaneous implantable cardioverter-defibrillator (S-ICD) system, particularly device-device communication and ATP delivery. BACKGROUND: Transvenous pacemakers and implantable cardioverter-defibrillators (ICDs) have considerable rates of lead complications. We examined the next step in multicomponent leadless cardiac rhythm management: feasibility of pacing (including ATP) by a LP, commanded by an implanted S-ICD through wireless, intrabody, device-device communication...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29740040/differences-in-pre-sleep-activity-and-sleep-location-are-associated-with-variability-in-daytime-nighttime-sleep-electrophysiology-in-the-domestic-dog
#2
Nóra Bunford, Vivien Reicher, Anna Kis, Ákos Pogány, Ferenc Gombos, Róbert Bódizs, Márta Gácsi
The domestic dog (Canis familiaris) is a promising animal model. Yet, the canine neuroscience literature is predominantly comprised of studies wherein (semi-)invasive methods and intensive training are used to study awake dog behavior. Given prior findings with humans and/or dogs, our goal was to assess, in 16 family dogs (1.5-7 years old; 10 males; 10 different breeds) the effects of pre-sleep activity and timing and location of sleep on sleep electrophysiology. All three factors had a main and/or interactive effect on sleep macrostructure...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29732386/naturally-occurring-canine-invasive-urothelial-carcinoma-a-model-for-emerging-therapies
#3
REVIEW
Breann C Sommer, Deepika Dhawan, Timothy L Ratliff, Deborah W Knapp
The development of targeted therapies and the resurgence of immunotherapy offer enormous potential to dramatically improve the outlook for patients with invasive urothelial carcinoma (InvUC). Optimization of these therapies, however, is crucial as only a minority of patients achieve dramatic remission, and toxicities are common. With the complexities of the therapies, and the growing list of possible drug combinations to test, highly relevant animal models are needed to assess and select the most promising approaches to carry forward into human trials...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29719660/evaluation-of-matrix-metalloproteinases-mmp-2-and-mmp-9-activity-in-serum-and-biochemical-and-hematological-parameters-in-spontaneous-canine-cutaneous-tumors-before-and-after-surgical-treatment
#4
Vahid Fathipour, Zohreh Khaki, Seyyed Mehdi Nassiri
Recently, matrix metalloproteinases (MMP), in particular the gelatinases MMP-2 and MMP-9, generally considered as tumor markers for clinical applications. A longitudinal 2-years follow-up survey was performed on dogs with cutaneous tumor. Serum samples were obtained from 22 dogs with different cutaneous tumors and 22 health dogs at the time of surgery and one month, three months and one year after surgery. Gelatin zymography, hematological and biochemical assessment were performed for all serum samples. The serum alkaline phosphatase activity in dogs with malignant tumors was significantly higher than that in dogs with benign tumors and control cases...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29718954/behavioural-risks-in-male-dogs-with-minimal-lifetime-exposure-to-gonadal-hormones-may-complicate-population-control-benefits-of-desexing
#5
Paul D McGreevy, Bethany Wilson, Melissa J Starling, James A Serpell
Castration of dogs is a widespread practise with clear justification in population control and knock-on benefits for animal welfare. Deleterious behavioural consequences of castration are believed to be negligible. Gonadectomy is widely recommended as part of a multi-factorial approach to prevent problems including aggression in dogs. However, the consequences of early castration on health are still being debated. The current study focused on the reported behaviour of 6,235 male dogs castrated before 520 weeks of life for reasons other than behavioural management, and calculated their percentage lifetime exposure to gonadal hormones (PLGH) as a proportion of their age at the time of being reported to the online Canine Behavioral Assessment and Research Questionnaire (C-BARQ)...
2018: PloS One
https://www.readbyqxmd.com/read/29705933/mesenchymal-stem-cells-form-3d-clusters-following-intraventricular-transplantation
#6
Nicole Jungwirth, Laura Salinas Tejedor, Wen Jin, Viktoria Gudi, Thomas Skripuletz, Veronika Maria Stein, Andrea Tipold, Andrea Hoffmann, Martin Stangel, Wolfgang Baumgärtner, Florian Hansmann
Mesenchymal stem cells (MSCs) are regarded as an immune privileged cell type with numerous regeneration-promoting effects. The in vivo behavior of MSC and underlying mechanisms leading to their regenerative effects are largely unknown. The aims of this study were to comparatively investigate the in vivo behavior of canine (cMSC), human (hMSC), and murine MSC (mMSC) following intra-cerebroventricular transplantation. At 7 days post transplantation (dpt), clusters of cMSC, hMSC, and mMSC were detected within the ventricular system...
April 28, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29701286/physiological-characterization-of-ocular-melanosis-affected-canine-melanocytes
#7
Ethan M Dawson-Baglien, Erica L Noland, Dodd G Sledge, Matti Kiupel, Simon M Petersen-Jones
OBJECTIVE: Cairn terriers with ocular melanosis (OM) accumulate large, heavily pigmented melanocytes in the anterior uvea. Darkly pigmented plaques develop within the sclera, leading us to hypothesize that OM uveal melanocytes may have an abnormal migratory capacity. ANIMALS STUDIED: Globes from OM-affected Cairn terriers and unaffected control eyes enucleated for reasons unrelated to this study were used for immunohistochemistry and to culture melanocytes for in vitro cell behavior assays...
April 27, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29699519/comprehensive-gene-expression-analysis-of-canine-invasive-urothelial-bladder-carcinoma-by-rna-seq
#8
Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Naoaki Matsuki
BACKGROUND: Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is necessary to improve our understanding of progression, diagnosis, and treatment of iUC. Companion canines are a preferred animal model of iUC due to spontaneous tumor development and similarity to human disease in terms of histopathology, metastatic behavior, and treatment response...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29687083/behavior-of-mandibular-canines-as-abutment-teeth-and-indirect-retainers-in-kennedy-class-ii-removable-partial-denture-prosthesis
#9
Marisol C Camacho, Yolanda R Gallardo, Roberto Ch Stegun, Bruno Costa, Newton Sesma
Purpose: The purpose of this study was to evaluate the behavior of mandibular canines acting as abutment teeth and indirect retainers of a Kennedy class II according to different designs: lingual rest and lingual rest associated with a reciprocal arm. Materials & methods: A resin cast with two simulated canine teeth was made in Ni-Cr alloy, representing a Kennedy class II mandibular arch. With the objective of simulating the resilience of the periodontal ligament, a polyurethane layer was added at the canine tooth's root...
March 2018: Heliyon
https://www.readbyqxmd.com/read/29661121/urothelial-carcinomas-of-the-urinary-bladder-with-plasmacytoid-or-rhabdoid-features-and-tendency-of-epithelial-mesenchymal-transition-in-3-dogs
#10
Susanne Je-Han Lin, Chi-Fei Kao, Fun-In Wang, Chian-Ren Jeng, Jih-Jong Lee, Lei-Ya Wang, Hui-Wen Chang, Yi-Jiun Chen, Chen-Hsuan Liu, Victor Fei Pang
Plasmacytoid and rhabdoid variants of urothelial carcinomas (UCs) of the urinary bladder have been described in humans with plasma cell-like or rhabdoid cellular appearance and aggressive clinical outcome. Canine UC of the bladder is generally classified as papillary/nonpapillary and infiltrating/noninfiltrating with limited information regarding other histological patterns. We report 3 cases of UC of the urinary bladder showing a unique discohesive cellular morphology with malignant behavior resembling the human plasmacytoid and rhabdoid variants of UC, which may raise some difficulties in diagnosis...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29651421/when-the-nose-doesn-t-know-canine-olfactory-function-associated-with-health-management-and-potential-links-to-microbiota
#11
REVIEW
Eileen K Jenkins, Mallory T DeChant, Erin B Perry
The impact of health, management, and microbiota on olfactory function in canines has not been examined in review. The most important characteristic of the detection canine is its sense of smell. Olfactory receptors are primarily located on the ethmoturbinates of the nasal cavity. The vomeronasal organ is an additional site of odor detection that detects chemical signals that stimulate behavioral and/or physiological changes. Recent advances in the genetics of olfaction suggest that genetic changes, along with the unique anatomy and airflow of the canine nose, are responsible for the macrosmia of the species...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29608406/immunohistochemical-expression-of-fxr1-in-canine-normal-tissues-and-melanomas
#12
Laura Nordio, Andreia T Marques, Cristina Lecchi, Alberto M Luciano, Damiano Stefanello, Chiara Giudice
Fragile X mental retardation-related protein 1 (FXR1) is a cytoplasmic RNA-binding protein highly conserved among vertebrates. It has been studied for its role in muscle development, inflammation, and tumorigenesis, being related, for example, to metastasizing behavior in human and canine uveal melanoma. Anti-FXR1 antibodies have never been validated in the canine species. To investigate FXR1 expression in canine melanocytic tumors, the present study tested two commercially available polyclonal anti-human FXR1 antibodies, raised in goat and rabbit, respectively...
April 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29570234/pilot-study-utilizing-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-glycolytic-phenotyping-of-canine-mast-cell-tumors
#13
Lynn R Griffin, Doug H Thamm, Laura E Selmic, E J Ehrhart, Elissa Randall
The goal of this prospective pilot study was to use naturally occurring canine mast cell tumors of various grades and stages as a model for attempting to determine how glucose uptake and markers of biologic behavior are correlated. It was hypothesized that enhanced glucose uptake, as measured by 2-[fluorine-18]fluoro-d-glucose-positron emission tomography/computed tomography (F18 FDG PET-CT), would correlate with histologic grade. Dogs were recruited for this study from a population referred for treatment of cytologically or histologically confirmed mast cell tumors...
March 23, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29554909/pelvic-modelling-and-the-comparison-between-plate-position-for-double-pelvic-osteotomy-using-artificial-cancellous-bone-and-finite-element-analysis
#14
William McCartney, Bryan MacDonald, Ciprian Andrei Ober, Rubén Lostado-Lorza, Fátima Somovilla Gómez
BACKGROUND: Finite element analysis was used to compare fixation methods for double pelvic osteotomy (DPO). Using 3D scanning a stereolithography (stl) image was produced of a canine pelvis and this was subsequently refined in computer aided design (CAD). Using the CAD files, the images were imported in MSC Marc software to produce a working finite element (FE) model with 3 dimensional tetrahedral elements with linear shaped functions. The dimensions of a precontoured pelvic osteotomy plate with eight screws and a twisted seven screw straight plate were used to build the 2 fixations implants for the FE models...
March 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29538681/effect-of-canine-oxytocin-receptor-gene-polymorphism-on-the-successful-training-of-drug-detection-dogs
#15
Akitsugu Konno, Miho Inoue-Murayama, Shinji Yabuta, Akiko Tonoike, Miho Nagasawa, Kazutaka Mogi, Takefumi Kikusui
Drug detection dogs can be trained to locate various prohibited drugs with targeted odors, and they play an important role in the interdiction of drug smuggling in human society. Recent studies provide the interesting hypothesis that the oxytocin system serves as a biological basis for co-evolution between dogs and humans. Here, we offer the new possibility that genetic variation of the canine oxytocin receptor (OXTR) gene may regulate the success of a dog's training to become a drug detection dog. A total of 340 Labrador Retriever dogs that were trained to be drug detection dogs in Japan were analyzed...
March 10, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29536014/aggression-toward-familiar-people-strangers-and-conspecifics-in-gonadectomized-and-intact-dogs
#16
Parvene Farhoody, Indika Mallawaarachchi, Patrick M Tarwater, James A Serpell, Deborah L Duffy, Chris Zink
Gonadectomy is widely used to treat and prevent behavior problems including the aggressive behavior of dogs. The aim of this study was to determine whether aggressive behavior toward familiar people, strangers, or other dogs was significantly different in dogs gonadectomized at various ages vs. intact dogs using the Canine Behavioral Assessment Research Questionnaire (C-BARQ) with multivariate analysis. Of 15,370 initial surveys, those for dogs reported to have been gonadectomized at less than 6 weeks of age or to correct a behavior problem, and those with incomplete answers to questions regarding independent or dependent variables were excluded, leaving 13,795 for the analysis of aggressive behavior toward familiar people: 13,498 for aggressive behavior toward strangers and 13,237 for aggressive behavior toward dogs...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29534457/strengths-and-weaknesses-of-pre-clinical-models-for-human-melanoma-treatment-dawn-of-dogs-revolution-for-immunotherapy
#17
REVIEW
Giuseppina Barutello, Valeria Rolih, Maddalena Arigoni, Lidia Tarone, Laura Conti, Elena Quaglino, Paolo Buracco, Federica Cavallo, Federica Riccardo
Despite several therapeutic advances, malignant melanoma still remains a fatal disease for which novel and long-term curative treatments are needed. The successful development of innovative therapies strongly depends on the availability of appropriate pre-clinical models. For this purpose, several mouse models holding the promise to provide insight into molecular biology and clinical behavior of melanoma have been generated. The most relevant ones and their contribution for the advancement of therapeutic approaches for the treatment of human melanoma patients will be here summarized...
March 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29466403/estimating-the-burden-of-rabies-in-ethiopia-by-tracing-dog-bite-victims
#18
Tariku Jibat Beyene, Monique C M Mourits, Abraham Haile Kidane, Henk Hogeveen
In developing countries where financial resources are limited and numerous interests compete, there is a need for quantitative data on the public health burden and costs of diseases to support intervention prioritization. This study aimed at estimating the health burden and post-exposure treatment (PET) costs of canine rabies in Ethiopia by an investigation of exposed human cases. Data on registered animal bite victims during the period of one year were collected from health centers in three districts, i.e...
2018: PloS One
https://www.readbyqxmd.com/read/29460951/quantifying-linear-enamel-hypoplasia-in-virunga-mountain-gorillas-and-other-great-apes
#19
Kate McGrath, Sireen El-Zaatari, Debbie Guatelli-Steinberg, Margaret A Stanton, Donald J Reid, Tara S Stoinski, Michael R Cranfield, Antoine Mudakikwa, Shannon C McFarlin
OBJECTIVE: Linear enamel hypoplasia (LEH) is a condition marked by localized reductions in enamel thickness, resulting from growth disruptions during dental development. We use quantitative criteria to characterize the depth of LEH defects and "normal" perikymata in great apes. We test the hypothesis that mountain gorillas have shallow defects compared to other taxa, which may have led to their underestimation in previous studies. MATERIALS AND METHODS: Previous attempts to characterize LEH morphology quantitatively have been limited in sample size and scope...
February 20, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29444154/associations-between-owner-personality-and-psychological-status-and-the-prevalence-of-canine-behavior-problems
#20
Nicholas H Dodman, Dorothy C Brown, James A Serpell
Behavioral problems are a major source of poor welfare and premature mortality in companion dogs. Previous studies have demonstrated associations between owners' personality and psychological status and the prevalence and/or severity of their dogs' behavior problems. However, the mechanisms responsible for these associations are currently unknown. Other studies have detected links between the tendency of dogs to display behavior problems and their owners' use of aversive or confrontational training methods...
2018: PloS One
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