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https://www.readbyqxmd.com/read/28202716/pattern-separation-and-goal-directed-behavior-in-the-aged-canine
#1
Shikha Snigdha, Michael A Yassa, Christina deRivera, Norton W Milgram, Carl W Cotman
The pattern separation task has recently emerged as a behavioral model of hippocampus function and has been used in several pharmaceutical trials. The canine is a useful model to evaluate a multitude of hippocampal-dependent cognitive tasks that parallel those in humans. Thus, this study was designed to evaluate the suitability of pattern separation task(s) for detecting age-related changes in canines. We also assessed the dogs' ability to show pattern separation and discrimination reversal, which provides a novel extension of the pattern separation learning literature...
March 2017: Learning & Memory
https://www.readbyqxmd.com/read/28168679/doggone-affordances-canine-perception-of-affordances-for-reaching
#2
Jeffrey B Wagman, Matthew D Langley, Valeri Farmer-Dougan
Performing any behavior requires perceiving affordances-whether and how that behavior can be performed. Perception of affordances exhibits action scaling-choices about when to transition between two different modes of behavior reflect the fit between action capabilities and environmental properties. The boundary between distances that are perceived to be reachable with an arm-only reach and those that are perceived to be reachable with an arm-plus-torso reach occurs at farther distances for long-armed than for short-armed people, but at the same ratio of object-distance-to-arm length for both groups...
February 6, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28160587/use-of-self-organizing-maps-for-analyzing-the-behavior-of-canines-displaced-towards-midline-under-interceptive-treatment
#3
V Gandía-Aguiló, R Cibrián, E Soria, A-J Serrano, L Aguiló, V Paredes, J-L Gandía
BACKGROUND: Displaced maxillary permanent canine is one of the more frequent findings in canine eruption process and it's easy to be outlined and early diagnosed by means of x-ray images. Late diagnosis frequently needs surgery to rescue the impacted permanent canine. In many cases, interceptive treatment to redirect canine eruption is needed. However, some patients treated by interceptive means end up requiring fenestration to orthodontically guide the canine to its normal occlusal position...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28152185/mechanical-properties-of-canine-osteosarcoma-affected-antebrachia
#4
Michele A Steffey, Tanya C Garcia, Leticia Daniel, Allison L Zwingenberger, Susan M Stover
OBJECTIVE: To determine the influence of neoplasia on the biomechanical properties of canine antebrachia. STUDY DESIGN: Ex vivo biomechanical study. SAMPLE POPULATION: Osteosarcoma (OSA)-affected canine antebrachia (n = 12) and unaffected canine antebrachia (n = 9). METHODS: Antebrachia were compressed in axial loading until failure. A load-deformation curve was used to acquire the structural mechanical properties of neoplastic and unaffected specimens...
February 2, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28131911/effect-of-orthodontic-force-on-expression-levels-of-ten-cytokines-in-gingival-crevicular-fluid
#5
Livia Nunes, Luciana Quintanilha, Giuseppe Perinetti, Jonas Capelli
Various types of inflammatory mediators are involved in the cascade of biological events behind tissue remodeling allowing orthodontic tooth movement. This split-mouth longitudinal study aimed to evaluate the gingival crevicular fluid (GCF) levels of ten cytokines, IL-6, IL-8, IL-10, IL-13, IL-17, IFN-γ, GM-CSF, MCP-1, MIP-1β and TNF-α, during initial orthodontic treatment. The sample comprised 15 healthy patients (9 males and 6 females, 13.9±2.5 years). The lower (test) incisors were moved using fixed appliance carrying a 0...
January 21, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28129097/expression-of-phosphorylated-kit-in-canine-mast-cell-tumor
#6
C H C Halsey, D H Thamm, K M Weishaar, J H Burton, J B Charles, D L Gustafson, A C Avery, E J Ehrhart
Canine cutaneous mast cell tumor (MCT) is the most common canine skin tumor and exhibits variable biologic behavior. Signaling through the KIT receptor tyrosine kinase promotes cellular proliferation and survival and has been shown to play a role in MCT progression. Despite investigations into numerous biomarkers and the proposal of several grading schemas, no single marker or grading system can accurately predict outcome in canine MCT. The first aim of this study was to develop an immunohistochemical assay to measure phosphorylated KIT (pKIT) to investigate its association with 2 commonly used grading systems and other established prognostic markers for canine MCT...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28129095/t-lymphocytes-in-histiocytic-sarcomas-of-flat-coated-retriever-dogs
#7
A Marcinowska, F Constantino-Casas, T Williams, T Hoather, B Blacklaws, J Dobson
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such tumors. The objective of this study was to examine the presence and expression of regulatory T cells in HS tumor samples. Forty tumors were included in this study. All tumors were immunolabeled for CD3, CD79a, CD25, CD45RA, and FOXP3. The proportion of positive cells was compared between tumors presenting as a localized primary soft tissue mass (soft tissue origin HS) and disseminated HS affecting viscera, especially the spleen (splenic origin HS)...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28119017/does-size-really-matter-investigating-cognitive-differences-in-spatial-memory-ability-based-on-size-in-domestic-dogs
#8
Megan S Broadway, Mystera M Samuelson, Jennie L Christopher, Stephanie E Jett, Heidi Lyn
The study of canine cognition can be useful in understanding the selective pressures affecting cognitive abilities. Dogs have undergone intensive artificial selection yielding distinctive breeds, which differ both phenotypically and behaviorally and no other species has a wider range in brain size. As brain size has long been hypothesized to relate to cognitive capacity, this species offers a useful model to further explore this relationship. The influence of physical size on canine cognition has not been thoroughly addressed, despite the fact that large dogs are often perceived to be 'smarter' than small dogs...
January 22, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28105715/gigantopithecus-blacki-a-giant-ape-from-the-pleistocene-of-asia-revisited
#9
Yingqi Zhang, Terry Harrison
Gigantopithecus blacki is the largest hominoid that ever lived. The consensus view is that it is a specialized pongine and late-surviving member of the Sivapithecus-Indopithecus lineage. It is known primarily from Early and Middle Pleistocene cave sites in southern China, dating from 2.0 Ma to almost 300 ka. The cause of its extinction in the late Middle Pleistocene is unknown, but ecological change or the arrival of Homo erectus may have been contributing factors. Gigantopithecus is highly specialized in its dentognathic anatomy, with a unique combination of features that distinguish it from all other hominoids...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28090645/neonatal-limb-amputation-an-unusual-form-of-postmortem-canine-predation
#10
Kimberley J Omond, Calle Winskog, Allan Cala, Roger W Byard
Cases of postmortem canine predation often involve elderly recluses and their dogs. The face, head, and genitalia are targeted. Two unusual cases of postmortem canine predation of abandoned newborns are described to demonstrate an unusual alternative pattern of mutilation related to the small size of the decedents, marked decomposition, and canine scavenging behavior. Both bodies were abandoned/concealed soon after birth and were subsequently disturbed by dogs. Both were markedly decomposed with absent arms...
January 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28069005/prognostic-efficacy-of-the-human-b-cell-lymphoma-prognostic-genes-in-predicting-disease-free-survival-dfs-in-the-canine-counterpart
#11
Mohamad Zamani-Ahmadmahmudi, Sina Aghasharif, Keyhan Ilbeigi
BACKGROUND: Canine B-cell lymphoma is deemed an ideal model of human non-Hodgkin's lymphoma where the lymphomas of both species share similar clinical features and biological behaviors. However there are some differences between tumor features in both species. In the current study, we sought to evaluate the prognostic efficacy of human B-cell lymphoma prognostic gene signatures in canine B-cell lymphoma. METHODS: The corresponding probe sets of 36 human B-cell lymphoma prognostic genes were retrieved from 2 canine B-cell lymphoma microarray datasets (GSE43664 and GSE39365) (76 samples), and prognostic probe sets were thereafter detected using the univariate and multivariate Cox proportional-hazard model and the Kaplan-Meier analysis...
January 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28068294/canine-olfaction-as-an-alternative-to-analytical-instruments-for-disease-diagnosis-understanding-dog-personality-to-achieve-reproducible-results
#12
Klaus Hackner, Joachim Pleil
Recent literature has touted the use of canine olfaction as a diagnostic tool for identifying pre-clinical disease status, especially cancer and infection from biological media samples. Studies have shown a wide range of outcomes, ranging from almost perfect discrimination, all the way to essentially random results. This disparity is not likely to be a detection issue; dogs have been shown to have extremely sensitive noses as proven by their use for tracking, bomb detection and search and rescue. However, in contrast to analytical instruments, dogs are subject to boredom, fatigue, hunger and external distractions...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28058543/genomic-profiling-of-canine-mast-cell-tumors-identifies-dna-copy-number-aberrations-associated-with-kit-mutations-and-high-histological-grade
#13
Hiroyuki Mochizuki, Rachael Thomas, Scott Moroff, Matthew Breen
Mast cell tumor (MCT) is the most common skin malignancy of domestic dogs and presents with a widely variable clinical behavior. Although activating KIT mutations are present in approximately 20% of canine MCTs, molecular etiology is largely unknown for the majority of this cancer. Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer...
January 5, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28035661/evidence-of-toothpick-groove-formation-in-neandertal-anterior-and-posterior-teeth
#14
Almudena Estalrrich, José Antonio Alarcón, Antonio Rosas
OBJECTIVES: During the microscopic examination of the Neandertal dentitions from El Sidrón (Spain) and Hortus (France), we found unusual fine parallel microstriations on the mesial and distal sides of all tooth types, near the cervix. As its appearance was similar to toothpick grooves described in other Homo species, it could correspond to early stages on its formation. To test this hypothesis we developed an experimental replication of a groove using grass stalks. MATERIALS AND METHODS: Comparisons between 204 isolated Neandertal teeth and the two experimental dental specimens corroborate that the marks correspond to initial stages of toothpick groove formation, and we propose a five-grade recording scale that summarized the groove formation process...
December 30, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27902609/influence-of-oral-health-behavior-and-sociodemographic-factors-on-remaining-teeth-in-korean-adults-2010-2012-korea-national-health-and-nutrition-examination-survey
#15
In-Seok Song, Kyungdo Han, Yeon-Jo Choi, Jae-Jun Ryu, Jun-Beom Park
In this study, the number and location of remaining teeth were analyzed according to sociodemographic variables, anthropometric measurements, and oral health behavior patterns. The hypothesis was that the number and location of remaining teeth would be affected by oral health behavior and by sociodemographic factors, such as education levels, household income, and urban/rural residency.This nationwide cross-sectional study was performed with a total of 36,026 representative Korean adults aged 19 and older. The data were taken from the 2012-2012 Korea National Health and Nutrition Examination Survey...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901234/air-powder-polishing-on-self-ligating-brackets-after-clinical-use-effects-on-debris-levels
#16
Mônica L S Castro Aragón, Leandro Santiago Lima, David Normando
Introduction: Debris buildup on brackets and arch surfaces is one of the main factors that can influence the intensity of friction between bracket and orthodontic wire. Objective: This study sought to evaluate the effect of air-powder polishing cleaning on debris levels of self-ligating ceramic brackets at the end of orthodontic treatment, compared to the behavior of conventional brackets. Methods: Debris levels were evaluated in metal conventional orthodontic brackets (n = 42) and ceramic self-ligating brackets (n = 42) on canines and premolars, arranged in pairs...
September 2016: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/27900754/ezrin-and-moesin-expression-in-canine-and-feline-osteosarcoma
#17
Juraj Hlavaty, Birgitt Wolfesberger, Marlene Hauck, Barbara Obermayer-Pietsch, Andrea Fuchs-Baumgartinger, Ingrid Miller, Ingrid Walter
Biological features of canine osteosarcomas (OS) differ markedly from those found in feline and resemble more human osteosarcomas, in particular for their high rate of metastasis and poor prognosis. Ezrin, radixin and moesin are members of the ERM protein family and link the actin cytoskeleton with the cell membrane. Ezrin and moesin have been shown to be of prognostic significance in tumor progression due to their role in the metastatic process. The objective of this study was to analyze ezrin and moesin protein expression in a series of dog (n = 16) and cat (n = 8) osteosarcoma samples using immunohistochemistry and western blot techniques...
November 30, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27892865/co-occurrence-of-a-metastatic-mammary-liposarcoma-and-an-ovarian-sex-cord-stromal-tumor-in-a-dog
#18
M Polinas, G P Burrai, V Marras, R Ariu, M T Zedda, S Pau, E Antuofermo
Sarcoma arising in the mammary gland is a rare tumor in dogs, and primary liposarcoma with metastatic behavior has never been previously reported among canine mammary tumors. A 14-year old female poodle had a mammary mass diagnosed as pleomorphic liposarcoma. Two years following surgical removal, the tumor recurred in the mammary gland with lymph node metastases. In addition, a sex-cord stromal tumor was identified in the ovary. Immunohistochemistry was performed on both tumors that were positive for oestrogen and progesterone receptors...
December 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27892708/antitumoral-effects-of-d-fraction-from-grifola-frondosa-maitake-mushroom-in-breast-cancer
#19
Eliana Noelia Alonso, María Julia Ferronato, Norberto Ariel Gandini, María Eugenia Fermento, Diego Javier Obiol, Alejandro López Romero, Julián Arévalo, María Emilia Villegas, María Marta Facchinetti, Alejandro Carlos Curino
D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell death, migration, invasion, and metastasis in MCF7 human breast cancer cells...
January 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27884124/community-based-interventions-to-enhance-knowledge-protective-attitudes-and-behaviors-towards-canine-rabies-results-from-a-health-communication-intervention-study-in-guangxi-china
#20
Hairong Wu, Jiao Chen, Lianbin Zou, Liefeng Zheng, Weichao Zhang, Zhenmu Meng, Ricardo J Soares Magalhaes, Youming Wang, Jingli Kang, Xiangdong Sun
BACKGROUND: In China canine rabies poses a serious public health problem in that human mortality ranks the second highest globally. While rabies health education interventions are advocated by WHO to be critical components of modern rabies control and prevention programs, available studies have not adequately investigated the relative efficacy of their implementation in at-risk populations. This study aims to measure and compare the effect on knowledge and protective behavior towards rabies of health education interventions that include a novel Short Messaging Service via cell phone (SMS) and rabies health information sessions (IS)...
November 24, 2016: BMC Infectious Diseases
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