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https://www.readbyqxmd.com/read/27909529/emergency-department-readmission-in-elderly-patients-after-acute-rhythm-or-rate-control-treatment-for-atrial-fibrillation
#1
Bonora Antonio, Turcato Gianni, Franchi Elena, Dilda Alice, Taioli Gabriele, Serafini Valentina, Sivero Valentina, Zannoni Massimo, Ricci Giorgio, Olivieri Oliviero
Atrial fibrillation (AF) is an age-related increasing disease, characterized by a high number of relapses frequently leading the patients to Emergency Department (ED). Despite AF relapses may be clinically heterogeneous, a proper management requires either a fast and effective restore of the sinus rhythm or a satisfactory control of the ventricular rate. Whether the strategy adopted in the ED could affect the course of disease is still debated. Therefore, the aim of our study was to evaluate the number of ED readmission for AF related symptoms and the event-free period in patients older than 70 years previously treated in ED for an AF recurrence, in order to assess a possible relationship with the acute strategy...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27907852/the-relevance-of-primary-tumour-location-in-patients-with-metastatic-colorectal-cancer-a-meta-analysis-of-first-line-clinical-trials
#2
Julian Walter Holch, Ingrid Ricard, Sebastian Stintzing, Dominik Paul Modest, Volker Heinemann
BACKGROUND: Retrospective subgroup analyses suggest that primary tumour location (PTL) has a prognostic importance and relates to response to targeted therapy. METHODS: We conducted a meta-analysis of first-line clinical trials available up to October 2016, which assessed the relevance of PTL in patients with metastatic colorectal cancer (mCRC). Right- and left-sided colorectal cancers were differentiated (RC and LC). RESULTS: In 13 first-line randomised controlled trials and one prospective pharmacogenetic study, RC was associated with a significantly worse prognosis compared with LC (hazard ratio [HR] for overall survival: 1...
November 28, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27904725/rotator-cuff-repair-in-patients-over-75-years-of-age-clinical-outcome-and-repair-integrity
#3
Jung Gwan Park, Nam Su Cho, Jong Hoon Song, Jong Hun Baek, Ho Yeon Jeong, Yong Girl Rhee
BACKGROUND: Some studies have shown significant functional improvement after rotator cuff (RC) repair in elderly patients. However, few studies have reported the healing potential of RC tears in elderly patients. METHODS: Twenty-five patients aged ≥ 75 years who underwent RC repair were enrolled. The mean age at the time of surgery was 78.3 years (range, 75 to 88 years) while the mean follow-up was 36.3 months (range, 18 to 114 months). We evaluated clinical and structural outcomes after RC repair in the retear and healed groups...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27904235/management-of-acute-work-related-shoulder-injuries-by-an-early-shoulder-assessment-program-efficiency-of-imaging-investigations
#4
Helen Razmjou, Sandra Lincoln, Christopher Geddes, Dragana Boljanovic, Iona Macritchie, Caterina Virdo-Cristello, Danielle Medeiros, Robin R Richards
Purpose: There has been a significant increase in the number of costly investigations of the shoulder joint over the past decade. The purposes of this study were to (1) describe the diagnostic imaging investigations ordered for injured workers seen at an Early Shoulder Physician Assessment (ESPA) program, (2) evaluate the impact of these investigations on final diagnosis and management, and (3) examine how efficient the program was by determining the appropriateness of referrals and whether costly imaging was justified...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27900197/research-priorities-of-international-sporting-federations-and-the-ioc-research-centres
#5
Caroline F Finch, Scott Talpey, Ashley Bradshaw, Torbjorn Soligard, Lars Engebretsen
BACKGROUND/AIM: To be fully effective, the prevention of injury in sport and promotion of athlete's health needs to be both targeted and underpinned by scientific evidence. This study aimed to identify the research priorities of International Sporting Federation (ISFs) compared to the current research focus of the International Olympic Committee Research Centres (IOC-RCs). METHODS: Online survey of ISF Medical Chairpersons (n=22, 69% response) and IOC-RC Directors (n=7, 78% response)...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900012/ubenimex-enhances-the-radiosensitivity-of-renal-cell-carcinoma-cells-by-inducing-autophagic-cell-death
#6
Shuai Liu, Xiaoqing Wang, Jiaju Lu, Liping Han, Yongfei Zhang, Zheng Liu, Sentai Ding, Zhao Liu, Dongbin Bi, Zhihong Niu
Renal cell carcinoma (RCC) is resistant to standard radiotherapy. Ubenimex, an aminopeptidase N inhibitor, is widely used as an adjunct therapy after surgery to enhance the function of immunocompetent cells and confer antitumor effects. Our previous study demonstrated that ubenimex induces autophagic cell death in RCC cells. Recently, the molecular mechanism of autophagy induction has been associated with radiosensitivity in RCC cells. In the present study, the ability of ubenimex to enhance RCC cell sensitivity to radiation via the induction of autophagic cell death was determined, and the mechanism of action of this effect was investigated...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898840/one-hour-portable-chamber-methane-measurements-are-repeatable-and-provide-useful-information-on-feed-intake-and-efficiency
#7
D L Robinson, M Cameron, A J Donaldson, S Dominik, V H Oddy
Feed intake (FI), live weight (LW), and ADG were recorded over 31 d in ninety-six 12-month-old ewes (progeny of 4 sires) given ad libitum access to chaffed lucerne/cereal hay. Methane (CH) and CO emissions of each ewe were measured for 40 to 60 min in portable accumulation chambers (PAC) and in respiration chambers (RC) over 22 h. Testing in RC increased the variability of FI on the test day and depressed the amount eaten from an average of 1,384 to 1,062 g/d; FI depression increased by 0.63 ± 0.24 percentage points for every kilogram of additional LW...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896578/is-there-evidence-for-a-close-connection-between-side-of-intravesical-tumor-location-and-ipsilateral-lymphatic-spread-in-lymph-node-positive-bladder-cancer-patients-at-radical-cystectomy-results-of-the-prometrics-2011-database
#8
M May, C Protzel, M W Vetterlein, M Gierth, J Noldus, A Karl, T Grimm, B Wullich, M O Grimm, P Nuhn, P J Bastian, J Roigas, B Hadaschik, C Gilfrich, M Burger, M Fisch, S Brookman-May, A Aziz, O W Hakenberg
PURPOSE: To evaluate the possible association between bladder tumor location and the laterality of positive lymph nodes (LN) in a prospectively collected multi-institutional radical cystectomy (RC) series. METHODS: The study population included 148 node-positive bladder cancer (BC) patients undergoing RC and pelvic lymph node dissection in 2011 without neoadjuvant chemotherapy and without distant metastasis. Tumor location was classified as right, left or bilateral and compared to the laterality of positive pelvic LN...
November 28, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27895110/nucleosome-occupancy-as-a-novel-chromatin-parameter-for-replication-origin-functions
#9
Jairo Rodriguez, Laura Lee, Bryony Lynch, Toshio Tsukiyama
Eukaryotic DNA replication initiates from multiple discrete sites in the genome termed origins of replication (origins). Prior to S phase, multiple origins are poised to initiate replication by recruitment of the pre-replicative complex (pre-RC). For proper replication to occur, origin activation must be tightly regulated. At the population level, each origin has a distinct firing time and frequency of activation within S phase. Many studies have showed that chromatin can strongly influence initiation of DNA replication...
November 28, 2016: Genome Research
https://www.readbyqxmd.com/read/27890803/neural-signatures-of-phonological-deficits-in-chinese-developmental-dyslexia
#10
Fan Cao, Xin Yan, Zhao Wang, Yanni Liu, Jin Wang, Gregory J Spray, Yuan Deng
There has been debate on whether phonological deficits explain reading difficulty in Chinese, since Chinese is a logographic language which does not employ grapheme-phoneme-correspondence rules and remote memorization seems to be the main method to acquire reading. In the current study, we present neuroimaging evidence that the phonological deficit is also a signature of Chinese dyslexia. Specifically, we found that Chinese children with dyslexia (DD) showed reduced brain activation in the left dorsal inferior frontal gyrus (dIFG) when compared to both age-matched controls (AC) and reading-matched controls (RC) during an auditory rhyming judgment task...
November 23, 2016: NeuroImage
https://www.readbyqxmd.com/read/27887694/reprint-of-assessing-the-impact-of-a-joint-human-porcine-intervention-package-for-taenia-solium-control-results-of-a-pilot-study-from-northern-lao-pdr
#11
Anna L Okello, Lian Thomas, Phouth Inthavong, Amanda Ash, Boualam Khamlome, Chattouphone Keokamphet, Kim Newberry, Charles G Gauci, Sarah Gabriël, Pierre Dorny, Rc Andrew Thompson, Marshall W Lightowlers, John Allen
Following confirmation that a remote village of approximately 300 inhabitants in northern Lao PDR was hyperendemic for the Neglected Tropical Disease Taenia solium, a pilot human-porcine therapeutic control intervention was implemented between October 2013 and November 2014. Mass drug administration with a three day albendazole 400mg protocol was offered to all eligible humans in October 2013 and March 2014. At these times, and again in October 2014, eligible village pigs received the anti-cysticercosis TSOL18 vaccination and an oral dose of oxfendazole anthelmintic at 30mg/kg, both repeated one month later...
November 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27885325/current-role-of-minimally-invasive-radical-cholecystectomy-for-gallbladder-cancer
#12
REVIEW
Giuseppe Zimmitti, Alberto Manzoni, Francesca Guerini, Marco Ramera, Paola Bertocchi, Francesca Aroldi, Alberto Zaniboni, Edoardo Rosso
Background. For Tis and T1a gallbladder cancer (GbC), laparoscopic cholecystectomy can provide similar survival outcomes compared to open cholecystectomy. However, for patients affected by resectable T1b or more advanced GbC, open approach radical cholecystectomy (RC), consisting in gallbladder liver bed resection or segment 4b-5 bisegmentectomy, with locoregional lymphadenectomy, is considered the gold standard while minimally invasive RC (MiRC) is skeptically considered. Aim. To analyze current literature on perioperative and oncologic outcomes of MiRC for patients affected by GbC...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27884497/effect-of-rotator-cuff-strengthening-as-an-adjunct-to-standard-care-in-subjects-with-adhesive-capsulitis-a-randomized-controlled-trial
#13
Pallavi Rawat, Charu Eapen, Kulathuran Pillai Seema
STUDY DESIGN: Randomized controlled trial. PURPOSE OF THE STUDY: To study the effect of adding rotator cuff (RC) muscles strengthening to joint mobilization and transcutaneous electrical nerve stimulation (TENS) in patients with adhesive capsulitis. METHODS: A prospective, parallel-group, randomised clinical trial was conducted on 42 patients. One group received TENS and joint mobilization and in the other group RC muscles strengthening was added...
November 21, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27873153/preoperative-determinant-of-early-postoperative-renal-function-following-radical-cystectomy-and-intestinal-urinary-diversion
#14
Tatsuo Gondo, Yoshio Ohno, Jun Nakashima, Takeshi Hashimoto, Yoshihiro Nakagami, Masaaki Tachibana
PURPOSE: To identify preoperative factors correlated with postoperative early renal function in patients who had undergone radical cystectomy (RC) and intestinal urinary diversion. METHODS: We retrospectively identified 201 consecutive bladder cancer patients without distant metastasis who had undergone RC at our institution between 2003 and 2012. The estimated glomerular filtration rate (eGFR) was calculated using the modified Chronic Kidney Disease Epidemiology equation before RC and 3 months following RC...
November 21, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27872664/general-and-domain-specific-contributions-to-creative-ideation-and-creative-performance
#15
Donggun An, Mark A Runco
The general objective of this study was to reexamine two views of creativity, one positing that there is a general creative capacity or talent and the other that creativity is domain-specific. These two views were compared by (a) testing correlations among measures of domain-general and domain-specific creativity and (b) examining how the general and the specific measures was each related to indices of knowledge, motivation, and personality. Participants were 147 college students enrolled in a foreign language course...
November 2016: Europe's journal of psychology
https://www.readbyqxmd.com/read/27871914/neonatal-levels-of-adiponectin-interleukin-10-and-interleukin-12-are-associated-with-the-risk-of-developing-type-1-diabetes-in-childhood-and-adolescence-a-nationwide-danish-case-control-study
#16
Steffen U Thorsen, Christian B Pipper, Stefanie Eising, Kristin Skogstrand, David M Hougaard, Jannet Svensson, Flemming Pociot
BACKGROUND/AIM: An in-depth understanding of the early phase of type 1 diabetes (T1D) pathogenesis is important for targeting primary prevention. We examined if 14 preselected mediators of immune responses differed in neonates that later developed T1D compared to control neonates. METHODS: The study is a case-control study with a 1:2 matching. The individuals were born between 1981 through 2002. Cases were validated using the National Patient Register and the Danish Childhood Diabetes Register...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27871890/respiratory-dynamics-in-phonation-and-breathing-a-real-time-mri-study
#17
Louisa Traser, Ali Caglar Özen, Fabian Burk, Michael Burdumy, Michael Bock, Bernhard Richter, Matthias Echternach
The respiratory system is a central part of voice production, but for phonation neither the underlying functional relations between diaphragm (DPH) and rib cage (RC), nor differences to normal breathing are yet understood. This study aims to compare respiratory dynamics in phonation and breathing via dynamic MRI of the lung. Images of the breathing apparatus of 6 professional singers were captured in a 1.5T MRI system in supine position during vital capacity breathing and maximal long sustained phonation at 3 different pitches and loudness conditions...
November 18, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27866245/the-impact-of-socioeconomic-status-on-perioperative-complications-and-oncologic-outcomes-in-patients-undergoing-radical-cystectomy
#18
David M Golombos, Padraic O'Malley, Patrick Lewicki, Daniel P Nguyen, Benjamin V Stone, Bashir Al Hussein Al Awamlh, Douglas S Scherr
PURPOSE: To examine if patients of lower socioeconomic status (SES) are at higher risk of perioperative complications and experience different oncologic outcomes after radical cystectomy (RC). METHODS: Retrospective review was performed on 383 consecutive non-metastatic patients who underwent definitive RC at a tertiary referral center. Along with clinical and pathologic parameters traditionally utilized for risk stratification, potential social determinants of health were estimated using US Census data...
November 19, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27865750/outcomes-following-radical-cystectomy-for-plasmacytoid-urothelial-carcinoma-defining-the-need-for-improved-local-cancer-control
#19
Patrick A Cockerill, John C Cheville, Stephen A Boorjian, Andrew Blackburne, Prabin Thapa, Robert F Tarrell, Igor Frank
OBJECTIVE: To evaluate oncologic outcomes after radical cystectomy (RC) in patients with plasmacytoid urothelial carcinoma (UC), and compared survival to that in patients with pure UC of the bladder. METHODS: We identified 46 patients with plasmacytoid UC and 972 with pure UC who were treated with RC between 1980 and 2009. All pathologic specimens were re-reviewed by a single GU pathologist. Patients were matched 1:2 by age, gender, ECOG performance status, pathological tumor stage and nodal status to patients with pure UC...
November 16, 2016: Urology
https://www.readbyqxmd.com/read/27862828/introduction-of-robotically-assisted-radical-cystectomy-within-an-established-enhanced-recovery-programme
#20
Catherine Miller, Nicholas J Campain, Rachel Dbeis, Mark Daugherty, Nicholas Batchelor, Elizabeth Waine, John S McGrath
OBJECTIVES: In recent years, there has been rapid adoption of robotically-assisted surgery (RAS) for the treatment of pelvic urological cancers. This is particularly true for radical prostatectomy (RP) where robotically-assisted laparoscopic prostatectomy (RALP) has become the predominant surgical approach across England. Despite this, less than 15% of patients undergoing radical cystectomy (RC) in England in 2014 underwent a robotically-assisted radical cystectomy (RARC). However, as expertise in RAS spreads, an increasing number of cancer centres are now adopting this approach for patients undergoing RC...
November 15, 2016: BJU International
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