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https://www.readbyqxmd.com/read/29338118/impact-of-quality-of-research-on-patient-outcomes-in-the-institute-of-medicine-2013-report-on-dietary-sodium
#1
Aaron Lucko, Chelsea Ta Doktorchik, Norm Rc Campbell
The 2013 Institute of Medicine report entitled "Sodium Intake in Populations: Assessment of Evidence" found inconsistent evidence of health benefit with dietary sodium intake <2300 mg/d. Different studies reported benefit and harm of population dietary intake <2300 mg/d. The Institute of Medicine committee, however, did not assess whether the methodology used in each of the studies was appropriate to examine dietary sodium and health outcomes. This review investigates the association of methodological rigor and outcomes of studies in the Institute of Medicine report...
January 16, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29335780/a-comparison-of-semi-automated-volumetric-vs-linear-measurement-of-small-vestibular-schwannomas
#2
Samuel MacKeith, Tilak Das, Martin Graves, Andrew Patterson, Neil Donnelly, Richard Mannion, Patrick Axon, James Tysome
OBJECTIVE: Accurate and precise measurement of vestibular schwannoma (VS) size is key to clinical management decisions. Linear measurements are used in routine clinical practice but are prone to measurement error. This study aims to compare a semi-automated volume segmentation tool against standard linear method for measuring small VS. This study also examines whether oblique tumour orientation can contribute to linear measurement error. STUDY DESIGN: Experimental comparison of observer agreement using two measurement techniques...
January 15, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29333463/characteristics-of-smoothing-filters-to-achieve-the-guideline-recommended-positron-emission-tomography-image-without-harmonization
#3
Yuji Tsutsui, Shinichi Awamoto, Kazuhiko Himuro, Yoshiyuki Umezu, Shingo Baba, Masayuki Sasaki
Objectives: The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was filled with 18F solution with a background activity of 2.65 kBq/mL and a sphere-to-background ratio of 4...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29332448/helical-therapy-is-safe-for-lung-stereotactic-body-radiation-therapy-despite-limitations-in-achieving-sharp-dose-gradients
#4
Neha P Amin, Adrian Nalichowski, Shauna Campbell, Jal Hyder, Robyn Spink, Andre A Konski, Michael Dominello
PURPOSE: We observed that many of our helical therapy lung stereotactic body radiation therapy plans did not meet the Radiation Therapy Oncology Group (RTOG) recommended R50% (volume of 50% of the prescription dose/planning target volume), which characterizes the steepness of dose fall off. We hypothesized that despite not meeting R50%, helical therapy lung stereotactic body radiation therapy plans would confer similar local control and minimal side effects as previously reported using nonhelical treatment platforms...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331324/rectal-culture-directed-antibiotic-prophylaxis-before-transrectal-prostate-biopsy-reduced-infectious-complications-and-healthcare-costs
#5
J V Baldissera-Aradas, L Rodríguez-Villamil, R Blanco-Fernández, C Pérez-García, G Viejo de la Guerra, I González-Rodríguez, J Mosquera-Madera
BACKGROUND: Transrectal ultrasound-guided prostate biopsy (TUPB) is associated with infectious complications (ICs), which are related to a greater prevalence of ciprofloxacin-resistant bacteria (CRB) in rectal flora. We examined the ICs that occurred in 2 groups: A guided antibiotic prophylaxis (GP) group and an empiric prophylaxis (EP) group. We assessed the financial impact of GP. MATERIAL AND METHODS: The GP group was studied prospectively (June 2013 to July 2014)...
January 10, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29329894/neoadjuvant-dose-dense-mvac-versus-gc-in-patients-with-ct3-4an0m0-bladder-cancer-treated-with-radical-cystectomy
#6
Homayoun Zargar, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Trinity J Bivalacqua, Philippe E Spiess, Peter C Black, Wassim Kassouf
BACKGROUND: Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC. METHODS: We retrospectively reviewed records of patients with urothelial cancer who received NAC and underwent cystectomy at 20 contributing institutions from 2000-2015...
January 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29328282/recommended-conceptual-optical-system-design-for-china-s-large-optical-infrared-telescope-lot
#7
Donglin Ma
Recently, China is planning to construct a new large optical-infrared telescope (LOT), in which the aperture of the primary mirror is as large as 12m. China's LOT is a general-purpose telescope, which is aimed to work with multiple scientific instruments such as spectrographs. Based on the requirements of LOT telescope, we have compared the performance of Ritchey-Chrétien (RC) design and Aplanatic-Gregorian (AG) design from the perspective of scientific performance and construction cost. By taking the primary focal ratio, Nasmyth focal ratio, and telescope's site condition into consideration, we finally recommend a RC f/1...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29327729/h5n1-influenza-virus-specific-mirna-like-small-rna-increases-cytokine-production-and-mouse-mortality-via-targeting-poly-rc-binding-protein-2
#8
Xihan Li, Zheng Fu, Hongwei Liang, Yanbo Wang, Xian Qi, Meng Ding, Xinlei Sun, Zhen Zhou, Ying Huang, Hongwei Gu, Limin Li, Xi Chen, Donghai Li, Quan Zhao, Fenyong Liu, Hua Wang, Jin Wang, Ke Zen, Chen-Yu Zhang
Infection of H5N1 influenza virus causes the highest mortality among all influenza viruses. The mechanisms underlying such high viral pathogenicity are incompletely understood. Here, we report that the H5N1 influenza virus encodes a microRNA-like small RNA, miR-HA-3p, which is processed from a stem loop-containing viral RNA precursor by Argonaute 2, and plays a role in enhancing cytokine production during H5N1 infection. Mechanistic study shows that miR-HA-3p targets poly(rC)-binding protein 2 (PCBP2) and suppresses its expression...
January 12, 2018: Cell Research
https://www.readbyqxmd.com/read/29327492/a-five-gene-signature-may-predict-sunitinib-sensitivity-and-serve-as-prognostic-biomarkers-for-renal-cell-carcinoma
#9
Yuan-Lei Chen, Guang-Ju Ge, Chao Qi, Huan Wang, Huai-Lan Wang, Li-Yang Li, Gong-Hui Li, Li-Qun Xia
Sunitinib resistance is, nowadays, the major challenge for advanced renal cell carcinoma patients. Illuminating the potential mechanisms and exploring effective strategies to overcome sunitinib resistance are highly desired. We constructed a reliable gene signature which may function as biomarkers for prediction of sunitinib sensitivity and clinical prognosis. The gene expression profiles were obtained from The Cancer Genome Atlas database. By performing GEO2R analysis, numerous differentially expressed genes (DEGs) were found to be associated with sunitinib resistance...
January 12, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29327177/influence-of-sampling-frequency-and-load-calculation-methods-on-quantification-of-annual-river-nutrient-and-suspended-solids-loads
#10
Ahmed Elwan, Ranvir Singh, Maree Patterson, Jon Roygard, Dave Horne, Brent Clothier, Geoffrey Jones
Better management of water quality in streams, rivers and lakes requires precise and accurate estimates of different contaminant loads. We assessed four sampling frequencies (2 days, weekly, fortnightly and monthly) and five load calculation methods (global mean (GM), rating curve (RC), ratio estimator (RE), flow-stratified (FS) and flow-weighted (FW)) to quantify loads of nitrate-nitrogen (NO3--N), soluble inorganic nitrogen (SIN), total nitrogen (TN), dissolved reactive phosphorus (DRP), total phosphorus (TP) and total suspended solids (TSS), in the Manawatu River, New Zealand...
January 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29327126/antipyretic-effect-of-herba-ephedrae-ramulus-cinnamomi-herb-pair-on-yeast-induced-pyrexia-rats-a-metabolomics-study
#11
Xiao-Ming Wang, Wen-Jie Xu, Liang-Kui Xu, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the antipyretic mechanism of Herba Ephedrae (Eph)-Ramulus Cinnamomi (RC) herb pair on yeast-induced pyrexia in rats. METHODS: Totally 30 qualifified male SD rats were randomly assigned to the normal control (NC) group, the pyrexia model (model) group, the Eph, RC and Eph-RC treatment groups by a random digital table, 6 rats in each group. Each rat received a 20% aqueous suspension of yeast (10 mL/kg) except the NC group. The 3 treatment groups were administered 8...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29324789/an-l213a-variant-of-%C3%AE-glycosidase-from-sulfolobus-solfataricus-with-increased-%C3%AE-l-arabinofuranosidase-activity-converts-ginsenoside-rc-to-compound-k
#12
Ji-Hyeon Choi, Kyung-Chul Shin, Deok-Kun Oh
Compound K (C-K) is a crucial pharmaceutical and cosmetic component because of disease prevention and skin anti-aging effects. For industrial application of this active compound, the protopanaxadiol (PPD)-type ginsenosides should be transformed to C-K. β-Glycosidase from Sulfolobus solfataricus has been reported as an efficient C-K-producing enzyme, using glycosylated PPD-type ginsenosides as substrates. β-Glycosidase from S. solfataricus can hydrolyze β-d-glucopyranoside in ginsenosides Rc, C-Mc1, and C-Mc, but not α-l-arabinofuranoside in these ginsenosides...
2018: PloS One
https://www.readbyqxmd.com/read/29320726/pullulanase-treatments-to-increase-resistant-starch-content-of-black-chickpea-cicer-arietinum-l-starch-and-the-effects-on-starch-properties
#13
Hilal Demirkesen-Bicak, Zeynep Tacer-Caba, Dilara Nilufer-Erdil
This study aimed to increase resistant starch (RS) content of black chickpeas (Cicer arietinum L.) by using pullulanase enzyme. Physicochemical and functional properties of enzyme treated starch (NE) was compared with that of enzyme-treated and gelatinized starch (GE) and the retrograded control starch (RC). RS contents for native black chickpea starch (NS) and black chickpea flour (NF) were measured as 15.2% and 5.0%, respectively. While for NE and GE, were found as 16.4% and 12.3%, respectively. Treatments made on the NS, increased the amount of RDS and reduced the amount of SDS significantly (p < ...
January 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29317236/effect-of-ultrasound-pretreatment-on-enzymolysis-and-physicochemical-properties-of-corn-starch
#14
Mei Li, Junxun Li, Chuanhe Zhu
In the paper, the effects of ultrasound on the enzymolysis properties of corn starch were investigated. The results showed that the rate of enzymolysis changed with the change of ultrasonic conditions. Ultrasound pretreatment starches reduced the time in liquefaction process, and resulted in significantly higher DE value in saccharification process. DE value was negatively correlated to PV, BV, SV, To, Tp, ΔHg, DO, DD, N-O'KI, RC, Mw and DP, respectively, and positively correlated to Mw/Mn. X-ray diffraction analysis showed that the relative crystallinity was reduced, and the starch exhibited an A-pattern...
January 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29314475/suppression-of-targeting-of-dbf4-dependent-kinase-to-pre-replicative-complex-in-g0-nuclei
#15
Takuya Okada, Gaku Okabe, Yon-Soo Tak, Satoru Mimura, Haruhiko Takisawa, Yumiko Kubota
Intact G0 nuclei isolated from quiescent cells are not capable of DNA replication in interphase Xenopus egg extracts, which allow efficient replication of permeabilized G0 nuclei. Previous studies have shown multiple control mechanisms for maintaining the quiescent state, but DNA replication inhibition of intact G0 nuclei in the extracts remains poorly understood. Here, we showed that pre-RC is assembled on chromatin, but its activation is inhibited after incubating G0 nuclei isolated from quiescent NIH3T3 cells in the extracts...
January 4, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29314290/oncogene-rna-helicase-ddx6-promotes-the-process-of-c-myc-expression-in-gastric-cancer-cells
#16
Kohei Taniguchi, Ayako Iwatsuki, Nobuhiko Sugito, Haruka Shinohara, Yuki Kuranaga, Yuki Oshikawa, Toshihiro Tajirika, Manabu Futamura, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
Human DEAD-box RNA helicase gene DDX6 was cloned from B-cell lymphoma cell line RC-K8. Previously, we reported that DDX6 acts as oncogene in several cancers such as colorectal cancer and hepatocellular carcinoma. However, the detailed mechanism of DDX6 action in carcinogenesis is largely unknown. In this study, we examined the functions of DDX6 in clinical gastric cancer (GC) samples and GC cells. DDX6 protein expression levels of cancer samples were higher than those of the adjacent normal tissues in 25 clinical GC samples (median value: 1...
January 4, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29313324/improved-spectrometer-microscope-for-quantitative-fluorescence-resonance-energy-transfer-measurement-based-on-simultaneous-spectral-unmixing-of-excitation-and-emission-spectra
#17
Fangrui Lin, Mengyan Du, Fangfang Yang, Lichun Wei, Tongsheng Chen
Based on our recently developed quantitative fluorescence resonance energy transfer (FRET) measurement method using simultaneous spectral unmixing of excitation and emission spectra (ExEm-spFRET), we here set up an improved spectrometer-microscope (SM) for implementing modified ExEm-spFRET (mExEm-spFRET), in which a system correction factor (fsc) is introduced. Our SM system is very stable for at least six months. Implementation of mExEm-spFRET with four or two excitation wavelengths on SM for single living cells expressing different FRET constructs obtained consistent FRET efficiency (E) and acceptor-donor concentration ratio (Rc) values...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29312867/quantitative-assessment-of-nonsolid-pulmonary-nodule-volume-with-computed-tomography-in-a-phantom-study
#18
Marios A Gavrielides, Benjamin P Berman, Mark Supanich, Kurt Schultz, Qin Li, Nicholas Petrick, Rongping Zeng, Jenifer Siegelman
Background: To assess the volumetric measurement of small (≤1 cm) nonsolid nodules with computed tomography (CT), focusing on the interaction of state of the art iterative reconstruction (IR) methods and dose with nodule densities, sizes, and shapes. Methods: Twelve synthetic nodules [5 and 10 mm in diameter, densities of -800, -630 and -10 Hounsfield units (HU), spherical and spiculated shapes] were scanned within an anthropomorphic phantom. Dose [computed tomography scan dose index (CTDIvol)] ranged from standard (4...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29312542/the-management-of-active-surveillance-in-prostate-cancer-validation-of-the-canary-prostate-active-surveillance-study-risk-calculator-with-the-spanish-urological-association-registry
#19
Ángel Borque-Fernando, José Rubio-Briones, Luis Mariano Esteban, Argimiro Collado-Serra, Yoni Pallás-Costa, Pedro Ángel López-González, Jorge Huguet-Pérez, José Ignacio Sanz-Vélez, Jesús Manuel Gil-Fabra, Enrique Gómez-Gómez, Cristina Quicios-Dorado, Lluis Fumadó, Sara Martínez-Breijo, Juan Soto-Villalba
The follow up of patients on active surveillance requires to repeat prostate biopsies. Predictive models that identify patients at low risk of progression or reclassification are essential to reduce the number of unnecessary biopsies. The aim of this study is to validate the Prostate Active Surveillance Study risk calculator (PASS-RC) in the multicentric Spanish Urological Association Registry of patients on active surveillance (AS), from common clinical practice. Results: We find significant differences in age, PSA and clinical stage between our validation cohort and the PASS-RC generation cohort (p < ...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29306188/ginsenosides-and-ginsenosidases-in-the-pathobiology-of-ginseng-cylindrocarpon-destructans-zinss-scholten
#20
Jiao Wang, Honglei Chen, Juan Gao, Jixun Guo, Xuesong Zhao, Yifa Zhou
To investigate the role that ginsenosides (and some of their metabolites) play in interactions between plants and phytopathogenic fungi (e.g. Cylindrocarpon destructans (Zinss) Scholten), we systematically determined the anti-fungal activities of six major ginsenosides (Rb1, Rb2, Rc, Rd, Re and Rg1), along with the metabolites of ginsenoside Rb1 (Gypenoside XVII (G-XVII) and F2), against the ginseng root pathogen C. destructans (Zinss) Scholten and non-ginseng pathogens Fusarium graminearum Schw., Exserohilum turcicum (Pass...
December 29, 2017: Plant Physiology and Biochemistry: PPB
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