keyword
MENU ▼
Read by QxMD icon Read
search

renal dose adjustment

keyword
https://www.readbyqxmd.com/read/27924664/assessment-of-ethnic-differences-in-sunitinib-outcome-between-caucasian-and-asian-patients-with-metastatic-renal-cell-carcinoma-a-meta-analysis
#1
Xiaoyan Liu, Marta Fiocco, Jesse J Swen, Henk-Jan Guchelaar
BACKGROUND: An increasing number of studies have reported ethnic differences in sunitinib outcome in metastatic renal cell carcinoma (mRCC) patients. However, a comprehensive analysis is still lacking. Therefore, we systematically collected available published data and performed a meta-analysis to compare sunitinib efficacy and toxicity in Asian and Caucasian mRCC patients. METHODS: Data were extracted from published results from clinical trials, expanded access program and real-world clinical practice...
December 7, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27885697/dynamic-effects-of-cyp3a5-polymorphism-on-dose-requirement-and-trough-concentration-of-tacrolimus-in-renal-transplant-recipients
#2
P Chen, J Li, J Li, R Deng, Q Fu, J Chen, M Huang, X Chen, C Wang
WHAT IS KNOWN AND OBJECTIVE: Tacrolimus is a widely used immunosuppressive drug with marked pharmacokinetic variability partly due to CYP3A5 polymorphism. Our study aimed to investigate the dynamic effects of CYP3A5 genotypes on dose requirement and trough concentration (C0 ) of tacrolimus in renal transplant recipients. METHODS: A total of 194 Chinese renal transplant recipients received oral tacrolimus twice daily. Whole-blood C0 of tacrolimus were measured on the 3rd day, 7th day, 14th day, 1st month, 3rd month and 6th month post-transplantation...
November 25, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27878526/intravenous-vancomycin-dosing-in-the-elderly-a-focus-on-clinical-issues-and-practical-application
#3
Katie E Barber, Allison M Bell, Kayla R Stover, Jamie L Wagner
The elderly population can be divided into three distinct age groups: 65-74 years (young-old), 75-84 years (middle-old), and 85+ years (old-old). Despite evidence of a shift in leading causes for mortality in the elderly from infectious diseases to chronic conditions, infections are still a serious cause of death in this population. These patients are at increased risk due to weakened immune systems, an increased prevalence of underlying comorbidities, and decreased physiologic reserves to fight infection. Additionally, elderly patients, especially adults in institutional settings, are at an increased risk of colonization and subsequent infection with methicillin-resistant Staphylococcus aureus at a rate that is five times higher than in younger individuals, causing an increase in empiric and definitive vancomycin use...
December 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27863186/model-based-characterization-of-the-pharmacokinetics-of-pembrolizumab-a-humanized-anti-pd-1-monoclonal-antibody-in-advanced-solid-tumors
#4
M Ahamadi, T Freshwater, M Prohn, C H Li, D P de Alwis, R de Greef, J Elassaiss-Schaap, A Kondic, J A Stone
Pembrolizumab, a potent antibody against programmed death 1 (PD-1) receptor, has shown robust antitumor activity and manageable safety in patients with advanced solid tumors. Its pharmacokinetic (PK) properties were analyzed with population PK modeling using pooled data from the KEYNOTE-001, -002, and -006 studies of patients with advanced melanoma, non-small cell lung cancer (NSCLC), and other solid tumor types. Pembrolizumab clearance was low and the volume of distribution small, as is typical for therapeutic antibodies...
November 14, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27856262/association-between-renal-function-and-chemotherapy-related-toxicity-in-older-adults-with-cancer
#5
Lindsay L Peterson, Arti Hurria, Tao Feng, Supriya G Mohile, Cynthia Owusu, Heidi D Klepin, Cary P Gross, Stuart M Lichtman, Ajeet Gajra, Ilya Glezerman, Vani Katheria, Laura Zavala, David D Smith, Can-Lan Sun, William P Tew
PURPOSE: To evaluate the association between renal function (RF) and chemotherapy-related toxicity (CRT) in older adults with cancer and to compare the effect of different RF formulas and body weight measurements on this association. METHODS: This is a secondary analysis of data from a prospective multicenter study of patients ≥ age 65 who were starting a new chemotherapy regimen. RF was estimated with 4 formulas (modified Jelliffe [Jelliffe], Cockcroft-Gault [CG], Wright, and Modification of Diet in Renal Disease [MDRD]), using actual, ideal and adjusted body weights for 492 patients...
November 14, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27852512/the-association-of-secondhand-tobacco-smoke-and-ct-angiography-verified-coronary-atherosclerosis
#6
David F Yankelevitz, Matthew D Cham, Harvey Hecht, Rowena Yip, Joseph Shemesh, Jagat Narula, Claudia I Henschke
OBJECTIVES: The aim of this study was to assess the relationship of the extent of atherosclerosis on coronary computed tomographic angiography to the extent of secondhand tobacco smoke (SHTS) exposure in asymptomatic never smokers. BACKGROUND: A dose-related association between SHTS and coronary artery calcium has been reported, but the total extent of atherosclerosis has not been investigated. METHODS: Two hundred sixty-eight never smokers, ages 40 to 80 years, completed a questionnaire assessing risk factors and extent of lifetime SHTS exposure, providing a total SHTS exposure score...
November 5, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27850336/697-influence-of-antibiotic-dose-adjustment-on-mortality-in-continuous-renal-replacement-therapy
#7
John Marshall, Jennifer Stevens, Ethan Smith
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27830927/observational-clinical-study-on-organ-dysfunction-associated-with-dosing-of-antibiotics-in-a-paediatric-intensive-care-unit
#8
Sascha Tafelski, Alexander Gratopp, Florian Richter, Sylvia Kramer, Claudia Spies, Klaus D Wernecke, Irit Nachtigall
BACKGROUND: Medication errors are of concern especially in paediatric patients. This study investigates impact of dosing errors of antibiotics on outcome in critically ill paediatric patients. METHODS: Retrospective study including all consecutive patients admitted to one university paediatric intensive care unit (PICU) in 2010 with length of PICU stay >24hrs, age <18 years and antibiotic therapy. Antibiotic dosages were evaluated for compliance with recommended dosing individually adapted for bodyweight, age and organ function...
November 10, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27823855/red-cell-distribution-width-and-the-risk-of-cerebral-vein-thrombosis-a-case-control-study
#9
Alberto Maino, Maria Abbattista, Paolo Bucciarelli, Andrea Artoni, Serena M Passamonti, Silvia Lanfranconi, Ida Martinelli
BACKGROUND: Red cell distribution width (RDW) is a marker of cardiovascular diseases and venous thromboembolism, but its role in cerebral vein thrombosis (CVT) is unknown. AIMS: To investigate whether high values of RDW are associated with an increased risk of CVT. METHODS: A case-control study of CVT patients (≥18years-old) referred to our center contrasted with healthy individuals. Odds ratios (ORs) were calculated for RDW values >90th percentile by multivariable logistic regression and adjusted for demographic characteristics, hemorheological parameters, renal function, fibrinogen and CRP...
November 4, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27816115/implications-of-serum-chloride-homeostasis-in-acute-heart-failure-from-rose-ahf
#10
Justin L Grodin, Jie-Lena Sun, Kevin J Anstrom, Horng H Chen, Randall C Starling, Jeffrey M Testani, W H Wilson Tang
Lower serum chloride (Cl) levels are strongly associated with increased long-term mortality after admission for acute heart failure (AHF). However, the therapeutic implications of serum Cl levels during AHF are unknown. We sought to determine the short-term clinical response and postdischarge outcomes associated with serum Cl levels in AHF. Serum Cl was measured at randomization (n = 358) and during hospitalization from patients with AHF in the Renal Optimization Strategies Evaluation in Acute Heart Failure trial...
September 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27804962/alcohol-consumption-and-the-risk-for-renal-hyperfiltration-in-the-general-chinese-population
#11
M Lin, Q Su, H Huang, Y Zheng, J Wen, J Yao, J Liang, L Li, W Lin, L Lin, J Lu, Y Bi, W Wang, G Ning, G Chen
BACKGROUND/OBJECTIVES: Glomerular hyperfiltration has been considered an early marker of kidney injury in prediabetes and prehypertension. Heavy alcohol consumption remains highly prevalent and is considered a major public health problem worldwide. The degree of glomerular hyperfiltration associated with alcohol consumption remains unclear. SUBJECTS/METHODS: This study was conducted in three communities in China. A total of 15 390 participants (5396 males and 9994 females) aged 40-65 years were included in the study...
November 2, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27799609/supratherapeutic-inr-resulting-from-the-initiation-of-warfarin-in-a-patient-receiving-axitinib
#12
Brian Primeaux, Bradley Burton, Stephanie Shuey
Axitinib is a vascular endothelial growth factor receptor inhibitor indicated for advanced renal cell cancer after failure of one prior systemic therapy. We report a case where a patient receiving axitinib experienced a supratherapeutic INR soon after initiation of an age-appropriate warfarin dose. We propose two possible mechanisms for this interaction, including competitive protein binding and decreased metabolism. Close INR monitoring and dose adjustments of warfarin may be necessary in patients receiving concomitant axitinib and warfarin in order to decrease the risks associated with this interaction...
October 31, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27799209/dosing-and-pharmacokinetics-of-polymyxin-b-in-renal-insufficiency
#13
Visanu Thamlikitkul, Yanina Dubrovskaya, Pooja Manchandani, Thundon Ngamprasertchai, Adhiratha Boonyasiri, Jessica T Babic, Vincent H Tam
Polymyxin B remains the last-line treatment option for multidrug-resistant Gram-negative bacterial infections. Current FDA-approved prescribing information recommends that polymyxin B dosing should be adjusted according to patient's renal function, despite studies have shown poor correlation between creatinine and polymyxin B clearance. The objective of the study was to determine if steady state polymyxin B exposures in patients with normal renal function were different from those with renal insufficiency. Nineteen adult patients who received intravenous polymyxin B (1...
October 31, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27798513/longitudinal-pharmacokinetics-of-everolimus-when-combined-with-low-level-of-tacrolimus-in-elderly-renal-transplant-recipients
#14
Elias David-Neto, Fabiana Agena, Fernanda Ramos, Ana Heloisa Triboni, Paschoalina Romano, Persio de Almeida Rezende Ebner, Venceslau Coelho, Nelson Zocoler Galante, Francine Carvalinho Lemos
BACKGROUND: Although the proportion of elderly patients among renal transplant recipients has increased, pharmacokinetic (PK) studies of immunosuppressants rarely include older patients. METHODS: We studied 12-hours everolimus (EVL) PK in 16 elderly renal transplant recipients (all caucasians; 10 males; mean age, 64±2 years, (61-71y), in 4 separate time-points (at 7, 30, 60 and 150 days) after EVL introduction, corresponding to a mean post renal-transplantation day: PK1 (43±4days), PK2 (65±7 days), PK3 (106±17 days) and PK4 (206±40 days)...
October 28, 2016: Transplantation
https://www.readbyqxmd.com/read/27797596/pharmacokinetics-and-pharmacodynamics-of-sofosbuvir-and-ledipasvir-for-the-treatment-of-hepatitis-c
#15
Francisca Cuenca-Lopez, Antonio Rivero, Antonio Rivero-Juárez
The sofosbuvir (SOF) plus ledipasvir (LDV) fixed dose combination is the first direct action antiviral (DAA) single-treatment regimen (STR) to be commercialized. It is approved for the treatment of Hepatitis C virus (HCV) genotypes 1,3,4,5 and 6. Following approval in 2014, new pharmacokinetics and pharmacodynamics data were reported, which led to important clinical applications. Areas covered: This article reviews the pharmacokinetic and pharmacodynamic properties of the SOF/LDV fixed dose combination for the treatment of HCV...
January 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27795374/pharmacokinetic-pharmacodynamic-modeling-and-simulation-of-cefiderocol-a-parenteral-siderophore-cephalosporin-for-dose-adjustment-based-on-renal-function
#16
Takayuki Katsube, Toshihiro Wajima, Toru Ishibashi, Juan Camilo Arjona Ferreira, Roger Echols
The novel parenteral siderophore cephalosporin, cefiderocol, exhibits potent efficacy against most Gram-negative bacteria including carbapenem-resistant strains. Since cefiderocol is primarily excreted via the kidneys, this study was conducted to develop a population pharmacokinetic (PK) model to determine dose adjustment based on renal function.Population PK models were developed based on cefiderocol concentration data in plasma, urine and dialysate with a non-linear mixed effects model approach. Monte-Carlo simulations were conducted to calculate the probability of target attainment (PTA) of fraction of time during the dosing interval where the free drug concentration in plasma exceeds the minimum inhibitory concentration (MIC) (Tf>MIC) for a MIC range of 0...
October 17, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27794023/the-effectiveness-and-safety-of-high-dose-colistin-prospective-cohort-study
#17
Yael Dishon Benattar, Muna Omar, Oren Zusman, Dafna Yahav, Yael Zak-Doron, Sergey Altunin, Michal Elbaz, Vered Daitch, Michal Granot, Leonard Leibovici, Mical Paul
BACKGROUND:  Optimizing colistin dosing should translate to improved patient outcomes. METHODS:  We used data from 2 prospective cohort studies performed between 2006 and 2009 and between 2012 and 2015. In the latter period, a new policy of high-dose colistin (9 million international units [MIU] loading dose followed by 9 MIU daily for normal renal function) was introduced in 2 participating hospitals. We included adult inpatients with invasive infections caused by carbapenem-resistant gram-negative bacteria treated with colistin...
October 6, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27783139/lack-of-effect-of-smoking-status-on-axitinib-pharmacokinetics-in-patients-with-non-small-cell-lung-cancer
#18
May Garrett, Timothy Taylor, Diane R Mould, Michael A Amantea, Ying Chen, Antonella Ingrosso, Yazdi K Pithavala
PURPOSE: Axitinib, a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptors 1-3, is approved for second-line treatment of advanced renal cell carcinoma. Axitinib is partially metabolized by cytochrome P450 1A2, which is induced by chronic heavy smoking. The effect of smoking on axitinib pharmacokinetics was evaluated in a non-small-cell lung cancer (NSCLC) patient population with a large number of active and ex-smokers. METHODS: Data were pooled from six clinical studies-serial pharmacokinetics from two healthy volunteer studies (n = 58) and sparse pharmacokinetics from four NSCLC studies (n = 152)-for a nonlinear mixed effects modeling (NONMEM v7...
October 25, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27780884/strength-of-evidence-for-labeled-dosing-recommendations-in-renal-impairment
#19
Joshua J Gagne, Nazleen F Khan, Tara S Raj, Lajja R Patel, Niteesh K Choudhry
BACKGROUND/AIMS: Renally excreted medications often require dose adjustment in patients with kidney impairment. While drug development and approval in the United States are typically based on several Phase I and II studies and one or more larger Phase III randomized trials, the basis for labeled dosing recommendations for patients with renal impairment is less well known. In response, we aimed to quantify the level of evidence used to recommend labeled dosing adjustments for newly approved drugs in patients with renal impairment...
October 24, 2016: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/27778374/prevalence-of-drug-related-problems-associated-with-direct-oral-anticoagulants-in-hospitalized-patients-a-multicenter-cross-sectional-study
#20
M Viprey, R Jeannin, V Piriou, P Chevalier, C Michel, G Aulagner, J Berthiller, X Armoiry
WHAT IS KNOWN AND OBJECTIVE: The complex dose regimens of the direct-acting oral anticoagulants (DOAC) make their appropriate prescribing highly challenging. Inappropriate prescribing of the DOAC remains poorly addressed. We studied the patterns of DOAC prescription and estimated the prevalence of drug-related problems (DRPs) associated with their use. METHODS: A cross-sectional study was conducted using data from medical records system of the Lyon teaching hospitals...
October 24, 2016: Journal of Clinical Pharmacy and Therapeutics
keyword
keyword
86723
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"