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https://www.readbyqxmd.com/read/29349891/research-on-the-preparation-uniformity-and-stability-of-mixed-standard-substance-for-rapid-detection-of-goat-milk-composition
#1
Yuying Zhu, Jianmin Wang, Cunfang Wang
Taking fresh goat milk as raw material after filtering, centrifuging, hollow fiber ultrafiltration, allocating formula, value detection and preparation processing, a set of 10 goat milk mixed standard substances was prepared on the basis of one-factor-at-a-time using a uniform design method, and its accuracy, uniformity and stability were evaluated by paired t-test and F-test of one-way analysis of variance. The results showed that three milk composition contents of these standard products were independent of each other, and the preparation using the quasi-level design method, and without emulsifier was the best program...
January 19, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29347948/prenatal-exposure-to-persistent-organic-pollutants-and-child-overweight-obesity-at-5-year-follow-up-a-prospective-cohort-study
#2
Hilde B Lauritzen, Tricia L Larose, Torbjørn Øien, Torkjel M Sandanger, Jon Ø Odland, Margot van de Bor, Geir W Jacobsen
BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. METHODS: Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted...
January 18, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29345984/development-of-a-polymerase-chain-reaction-ligase-detection-reaction-assay-for-detection-of-cyp2c19-polymorphisms
#3
Jing Zhang, Hui Zhang, Kun Li, Ming Shi
AIMS: Cytochrome P450 2C19 (CYP2C19) genotypes are associated with differential drug metabolism. The aim of this study was to establish a reliable assay for CYP2C19 genotyping based on a polymerase chain reaction/ligase detection reaction (PCR-LDR). MATERIALS AND METHODS: Specific primers and probes were designed to detect CYP2C19*1, *2, *3, and *17. A control for each allele was prepared and used for performance evaluation. A total of 200 clinical samples were analyzed using the PCR-LDR assay and Sanger sequencing...
January 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29345934/zein-nanoparticles-as-eco-friendly-carrier-systems-for-botanical-repellents-aiming-sustainable-agriculture
#4
Jhones Luiz Oliveira, Estefania Vangelie Ramos Campos, Anderson do Espirito Santo Pereira, Tatiane Pasquoto, Renata Lima, Renato Grillo, Daniel Junior de Andrade, Fabiano Aparecido Dos Santos, Leonardo F Fraceto
Botanical repellents represent one of the main ways of reducing the use of synthetic pesticides and the contamination of soil and hydric resources. However, the poor stability and rapid degradation of these compounds in the environment hinders their effective application in the field. Zein nanoparticles can be used as eco-friendly carrier systems to protect these substances against premature degradation, provide desirable release characteristics, and reduce toxicity in the environment and to humans. In this study, we describe the preparation and characterization of zein nanoparticles loaded with the main constituents of the essential oil of citronella (geraniol and R-citronellal)...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29339313/the-human-body-odor-compound-androstadienone-increases-neural-interference-coupled-to-higher-behavioral-costs-during-an-emotional-stroop-task
#5
Jonas Hornung, Lydia Kogler, Michael Erb, Jessica Freiherr, Birgit Derntl
The androgen derivative androstadienone (AND) is a substance found in human sweat and thus may act as human chemosignal. With the current experiment, we aimed to explore in which way AND affects interference processing during an emotional Stroop task which used human faces as target and emotional words as distractor stimuli. This was complemented by functional magnetic resonance imaging (fMRI) to unravel the neural mechanism of AND-action. Based on previous accounts we expected AND to increase neural activation in areas commonly implicated in evaluation of emotional face processing and to change neural activation in brain regions linked to interference processing...
January 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29338751/evaluation-of-the-effects-of-a-designated-program-on-illegal-drug-cessation-among-adolescents-who-experiment-with-drugs
#6
Chiu-Ching Chang, Jung-Yu Liao, Chiu-Mieh Huang, Hsiao-Pei Hsu, Chih-Che Chen, Jong-Long Guo
BACKGROUND: Studies indicate that adolescent-onset drug users experience a greater likelihood of dependence that continues into adulthood. The importance of early intervention was evident in treating adolescents before their substance use progressed. We examined the effectiveness of an intervention program that prevents students who experiment with drugs from reusing them. METHODS: The study was based on 10 out of 18 invited schools that were randomly assigned to either the intervention group (5 schools, n = 43) or the comparison group (5 schools, n = 41)...
January 16, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29338581/perceived-discrimination-as-a-risk-factor-for-use-of-emerging-tobacco-products-more-similarities-than-differences-across-demographic-groups-and-attributions-for-discrimination
#7
Jennifer B Unger
BACKGROUND: Perceived discrimination has been associated with cigarette smoking and other substance use among members of disadvantaged minority groups. However, most studies have focused on a single minority group, have not considered the individual's attribution for the discrimination, and have not considered emerging tobacco products. OBJECTIVE: This study examined the associations between perceived discrimination and use of six tobacco products (cigarettes, e-cigarettes, cigars, pipe tobacco, hookah, and smokeless tobacco) in a diverse sample of 1,068 adults in the United States...
January 17, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29338429/study-of-aflatoxicosis-reduction-effect-of-alchornea-cordifolia-on-biomarkers-in-an-aflatoxin-b1-exposed-rats
#8
Jean-Baptiste Aholia Adépo, Pierre Manda, Jean Verdier Ngbé, Aïssata Diakité, Béatrice Tigori Sangaré, Sébastien Djédjé Dano
The toxicity of aflatoxins results in cancer and liver disease. Several natural substances such as plants exhibited their ability to inhibit the initiation of aflatoxin carcinogenesis. The aim of this study was to evaluate the effect of Alchornea cordifolia on biomarkers in an aflatoxin B1 (AFB1) exposed rats. The contents of polyphenols, flavonoids and the antioxidant activity of A. cordifolia ethanolic leaf extract (EELac) were assessed. Groups of rats were treated orally with a daily dose of a mixture of AFB1 at a dose of 150 μg/kg body weight and EELac (50, 100 and 300 mg/kg body weight) for 21 days...
January 17, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29337238/advantages-of-the-alpha-lipoic-acid-association-with-chlorpromazine-in-a-model-of-schizophrenia-induced-by-ketamine-in-rats-behavioral-and-oxidative-stress-evidences
#9
Luis Rafael Leite Sampaio, Francisco Maurício Sales Cysne Filho, Jamily Cunha de Almeida, Danilo Dos Santos Diniz, Cláudio Felipe Vasconcelos Patrocínio, Caren Nádia Soares de Sousa, Manoel Cláudio Azevedo Patrocínio, Danielle S Macêdo, Silvânia Maria Mendes Vasconcelos
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats...
January 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29336191/teratogenic-potential-of-nanoencapsulated-vitamin-a-evaluated-on-an-alternative-model-organism-the-tunicate-ciona-intestinalis
#10
Roberta Pennati, Raoul Manenti, Antonella Stillitano, Gentile Francesco Ficetola, Giorgio Scarì, Silvia Mercurio, Elena Menegola
Nano-encapsulation is a technology used to pack substances in order to enhance their stability and bioavailability, but this packing may interact with living systems, causing unexpected toxicity. Vitamin A (vit A) is a substance that has received attention, because in developed countries, the increasing availability of supplements is leading to its excessive intake. This study aims to compare teratogenic effects caused by exposure to the traditional formulation of vit A versus nano-encapsulated vit A. We used ascidian embryos as an alternative model...
January 16, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29335765/wastewater-based-tracing-of-doping-use-by-the-general-population-and-amateur-athletes
#11
Ana Causanilles, Vera Nordmann, Dennis Vughs, Erik Emke, Olivier de Hon, Félix Hernández, Pim de Voogt
The present study investigates the applicability of the chemical analysis of wastewater to assess the use of doping substances by the general population and amateur athletes. To this end, an analytical methodology that can identify and quantify a list of 15 substances from the groups of anabolic steroids, weight loss products, and masking agents in wastewater has been developed. The method uses solid phase extraction to increase the detection sensitivity of the target analytes, expected to be present at very low concentrations (ng L-1 range), and decrease possible matrix interferences...
January 15, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29334656/activated-protein-c-suppresses-osteoclast-differentiation-via-endothelial-protein-c-receptor-protease-activated-receptor-1-sphingosine-1-phosphate-receptor-and-apolipoprotein-e-receptor-2
#12
Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
INTRODUCTION: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that anticoagulant activated protein C (APC) promotes osteoblast proliferation, but the role of the blood coagulation system in bone remodeling remains unclear. In this study, to further elucidate the relationship between bone remodeling and blood coagulation, we investigated the effect of APC on osteoclast differentiation...
January 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29334653/depletion-study-withdrawal-period-calculation-and-bioaccumulation-of-sulfamethazine-in-tilapia-oreochromis-niloticus-treated-with-medicated-feed
#13
Kátia S D Nunes, José H Vallim, Márcia R Assalin, Sonia C N Queiroz, Lourival C Paraíba, Claudio M Jonsson, Felix G R Reyes
The residue depletion of sulfamethazine (SMZ) was evaluated in tilapia (Oreochromis niloticus) after 11 days of administration of medicated feed containing SMZ, at the dose of 422 mg/kg body weight (bw). The determination of SMZ in feed and tilapia fillet was carried out using the QuEChERS approach for sample preparation, and high performance liquid chromatography with diode array detector (HPLC-DAD) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-MS) for quantitation, respectively...
January 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29334004/examining-residence-status-as-a-risk-factor-for-health-risk-behaviors-among-college-students
#14
Angelo M DiBello, Madeline B Benz, Mary Beth Miller, Jennifer E Merrill, Kate B Carey
OBJECTIVE: The current study aimed to evaluate college student residence as a unique risk factor for a range of negative health behaviors. PARTICIPANTS: We examined data from 63,555 students (66% female) from 157 campuses who completed the National College Health Assessment Survey in Spring 2011. METHODS: Participants answered questions about the frequency of recent use of alcohol, tobacco, marijuana, and illicit drugs as well as sexual risk behavior in the last 30 days...
January 15, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29333692/measuring-spatial-and-temporal-trends-of-nicotine-and-alcohol-consumption-in-australia-using-wastewater-based-epidemiology
#15
Foon Yin Lai, Coral Gartner, Wayne Hall, Steve Carter, Jake O'Brien, Benjamin J Tscharke, Frederic Been, Cobus Gerber, Jason White, Phong Thai, Raimondo Bruno, Jeremy Prichard, K Paul Kirkbride, Jochen F Mueller
BACKGROUND AND AIMS: Tobacco and alcohol consumption remain priority public health issues worldwide. As participation in population-based surveys has fallen, it is increasingly challenging to estimate accurately the prevalence of alcohol and tobacco use. Wastewater-based epidemiology (WBE) is an alternative approach for estimating substance use at the population level that does not rely on survey participation. This study examined spatio-temporal patterns in nicotine (a proxy for tobacco) and alcohol consumption in the Australian population via WBE...
January 14, 2018: Addiction
https://www.readbyqxmd.com/read/29333572/possible-protective-effect-of-the-algae-spirulina-against-nephrotoxicity-induced-by-cyclosporine-a-and-or-gamma-radiation-in-rats
#16
Maha M Aziz, Nihad I Eid, Ahmed S Nada, Nour El-Din Amin, Afaf A Ain-Shoka
The present study was conducted to evaluate the possible protective role of the algae spirulina (Sp) against nephrotoxicity and oxidative stress which are the main secondary effects induced by the immunosuppressant drug CSA and/or ionizing radiation. In this study, male rats were given Sp (1 g/kg) either for 15 days before irradiation (6.5 Gy) or 5 days before and 10 days concomitant with CSA (25 mg/kg). Markers used to assess renal injury included serum creatinine, urea, glucose, albumin, protein, and lipid profile as well as kidney content of reduced glutathione (GSH); lipid peroxidation (thiobarbituric acid reactive substances (TBARS)); nitrite and superoxide dismutase (SOD) activity...
January 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29333144/did-creatinine-standardization-give-benefits-to-the-evaluation-of-glomerular-filtration-rate
#17
Laurence Piéroni, Anne-Sophie Bargnoux, Jean-Paul Cristol, Etienne Cavalier, Pierre Delanaye
During the last decade, a lot of efforts has been made to improve the evaluation of renal functions. Measured Glomerular Filtration Rate (GFR) remains the only valuable test to confirm or confute the status of chronic kidney disease (CKD) and is recommended by Kidney Disease Global Outcomes guidelines when estimation of GFR is not reliable. However, in routine clinical practice, serum creatinine remains the one of the most prescribed biological parameters and is an undeniable factor, alone or in association with other parameters, of the estimation of GFR...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333037/curcumin-and-natural-derivatives-inhibit-ebola-viral-proteins-an-in-silico-approach
#18
Shruti Baikerikar
Background: Ebola viral disease is a severe and mostly fatal disease in humans caused by Ebola virus. This virus belongs to family Filoviridae and is a single-stranded negative-sense virus. There is no single treatment for this disease which puts forth the need to identify new therapy to control and treat this fatal condition. Curcumin, one of the bioactives of turmeric, has proven antiviral property. Objective: The current study evaluates the inhibitory activity of curcumin, bisdemethoxycurcumin, demethoxycurcumin, and tetrahydrocurcumin against Zaire Ebola viral proteins (VPs)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332494/an-evaluation-of-adolescent-and-young-adult-re-victimization-experiences-problematic-substance-use-and-negative-consequences
#19
D J Angelone, Tiffany Marcantonio, Jessica Melillo
We investigated substance use and negative consequences in women who experienced an initial sexual assault (SA) in high school and subsequently in college. More than 650 participants completed questionnaires assessing substance use/consequences, SA history, and posttraumatic stress disorder (PTSD) symptomology. Revictimized women reported differential substance use/consequences relative to controls underscoring the need to conceptualize adolescence as a key developmental period with a unique pathway to a subsequent SA, especially in association with substance use...
June 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29331733/aronia-melanocarpa-fruit-juice-ameliorates-the-symptoms-of-inflammatory-bowel-disease-in-tnbs-induced-colitis-in-rats
#20
Stefka Valcheva-Kuzmanova, Atanas Kuzmanov, Vasilena Kuzmanova, Maria Tzaneva
Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been proposed as mechanisms underlying the pathophysiology of IBD. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in polyphenolic substances, mainly proanthocyanidins, flavonoids and phenolic acids. The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine...
January 10, 2018: Food and Chemical Toxicology
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