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https://www.readbyqxmd.com/read/28324720/highly-sensitive-electrochemical-detection-of-palmatine-using-a-biocompatible-multiwalled-carbon-nanotube-poly-l-lysine-composite
#1
Balamurugan Thirumalraj, Subbiramaniyan Kubendhiran, Shen-Ming Chen, Kuan-Yu Lin
To date, the natural alkaloids are mostly used in the field of pharmacological applications and the active substance of palmatine was extensively used in cancer therapy and other biomedical applications. Hence, in this study we report a simple preparation of poly-l-lysine (PLL) electro-polymerized on the surface of functionalized multiwalled carbon nanotubes (f-MWCNT) for electrochemical detection of palmatine content in human serum and urine samples. The active amino group of PLL plays a vital role towards the oxidation palmatine and exhibits superior electrocatalytic activity...
March 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28319888/heterogeneous-reaction-of-peroxyacetyl-nitrate-pan-on-soot
#2
Ximeng Zhao, Tianyu Gao, Jianbo Zhang
The interaction between photochemical oxidants and aerosol particles has been examined in previous atmospheric pollution studies. The heterogeneous reaction can affect the concentration of gases and free radicals, as well as the morphology and properties of particles. In this report, the interaction between the photochemical oxidant peroxyacetyl nitrate (PAN) and soot particles was investigated using a flow tube system. We used real-time online monitoring equipment to track changes in PAN concentrations. Substances on the soot surface were detected using ion chromatography (IC), x-ray photoelectron spectroscopy (XPS), and other surface analysis methods...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28318787/municipal-wastewater-treatment-plant-effluent-induced-effects-on-freshwater-mussel-populations-and-the-role-of-mussel-refugia-in-recolonizing-an-extirpated-reach
#3
Patricia L Gillis, Rodney McInnis, Joseph Salerno, Shane R de Solla, Mark R Servos, Erin M Leonard
Global human population and urbanization continually increase the volume of wastewater entering aquatic environments. Despite efforts to treat these effluents, they contribute a diverse suite of substances that enter watersheds at concentrations that have the potential to elicit adverse effects on aquatic organisms. The relationship between wastewater treatment plant (WWTP) effluent exposure and biological responses within aquatic ecosystems remains poorly understood, especially at the population level. To examine the effect of WWTP effluents on sentinel invertebrates, freshwater mussels were assessed in the Grand River, Ontario, in populations associated with the outfall of a major WWTP...
March 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28314523/detection-of-anabolic-and-androgenic-steroids-and-or-their-esters-in-horse-hair-using-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#4
Karen Y Kwok, Timmy L S Choi, Wai Him Kwok, Jenny K Y Wong, Terence S M Wan
Anabolic and androgenic steroids (AASs) are a class of prohibited substances banned in horseracing at all times. The common approach for controlling the misuse of AASs in equine sports is by detecting the presence of AASs and/or their metabolites in urine and blood samples using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). This approach, however, often falls short as the duration of effect for many AASs are longer than their detection time in both urine and blood...
March 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28314152/monitoring-a-large-number-of-pesticides-and-transformation-products-in-water-samples-from-spain-and-italy
#5
Nikolaos I Rousis, Richard Bade, Lubertus Bijlsma, Ettore Zuccato, Juan V Sancho, Felix Hernandez, Sara Castiglioni
Assessing the presence of pesticides in environmental waters is particularly challenging because of the huge number of substances used which may end up in the environment. Furthermore, the occurrence of pesticide transformation products (TPs) and/or metabolites makes this task even harder. Most studies dealing with the determination of pesticides in water include only a small number of analytes and in many cases no TPs. The present study applied a screening method for the determination of a large number of pesticides and TPs in wastewater (WW) and surface water (SW) from Spain and Italy...
March 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28299694/electrochemical-quartz-crystal-nanobalance-eqcn-based-biosensor-for-sensitive-detection-of-antibiotic-residues-in-milk
#6
Sunil Bhand, Geetesh K Mishra
An electrochemical quartz crystal nanobalance (EQCN), which provides real-time analysis of dynamic surface events, is a valuable tool for analyzing biomolecular interactions. EQCN biosensors are based on mass-sensitive measurements that can detect small mass changes caused by chemical binding to small piezoelectric crystals. Among the various biosensors, the piezoelectric biosensor is considered one of the most sensitive analytical techniques, capable of detecting antigens at picogram levels. EQCN is an effective monitoring technique for regulation of the antibiotics below the maximum residual limit (MRL)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28293767/gambling-in-a-national-u-s-veteran-population-prevalence-socio-demographics-and-psychiatric-comorbidities
#7
Elina A Stefanovics, Marc N Potenza, Robert H Pietrzak
This study aimed to examine associations between gambling level and clinically relevant measures, including psychiatric disorders and suicidality, in a nationally representative sample of U.S. veterans. Data on 3157 U.S. veterans were analyzed from the National Health and Resilience in Veterans Study. Chi square tests and analyses of variance were used to assess associations between gambling level, and demographic, military, and personality characteristics. Multinomial logistic regressions using stepwise selection were used to identify independent correlates of recreational gambling and at-risk/problem gambling (ARPG)...
March 14, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28288606/monitoring-heavy-metals-residual-agricultural-chemicals-and-sulfites-in-traditional-herbal-decoctions
#8
In-Sil Yu, Jeong-Sook Lee, Sung-Dan Kim, Yun-Hee Kim, Hae-Won Park, Hoe-Jin Ryu, Jib-Ho Lee, Jeong-Mi Lee, Kweon Jung, Cheol Na, Jin-Yong Joung, Chang-Gue Son
BACKGROUND: Asian traditional herbal preparations are frequently considered for the contamination with undeclared toxic or hazardous substances. The aim of this study was to determine the toxic heavy metals, pesticides and sulfur dioxide in decoctions that is a common form of final utilization in Korea. METHODS: A total of 155 decoctions composed of multi-ingredient traditional herbs were randomly sampled from Seoul in Korea between 2013 and 2014. For each decoction, the concentrations of four heavy metals (arsenic, cadmium, lead and mercury), 33 pesticides and sulfur dioxide were analyzed using inductively coupled plasma mass spectrometry (ICP-MS), mercury analyzer, gas chromatography/nitrogen phosphorous detector (GC/NPD), gas chromatography/micro electron capture detector (GC/μECD), and Monier-Williams method respectively...
March 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28285550/the-inhibition-of-udp-glucuronosyltransferases-ugts-by-tetraiodothyronine-t4-and-triiodothyronine-t3
#9
Da-Wei Chen, Zuo Du, Chun-Ze Zhang, Wei-Hua Zhang, Yun-Feng Cao, Hong-Zhi Sun, Zhi-Tu Zhu, Kun Yang, Yong-Zhe Liu, Ze-Wei Zhao, Zhi-Wei Fu, Wen-Qing Gu, Yang Yu, Zhong-Ze Fang
1. UDP-glucuronosyltransferases (UGTs) are important drug-metabolizing enzymes (DMEs) catalyzing the glucuronidation elimination of various xenobiotics and endogenous substances. Endogenous substances are important regulators for the activity of various UGT isoforms. Triiodothyronine (T3) and thyroxine (T4) are important thyroid hormones essential for normal cellular differentiation and growth. The present study aims to elucidate the inhibition behavior of T3 and T4 on the activity of UGT isoforms. 2. In vitro recombinant UGTs-catalyzed glucuronidation of 4-methylumbelliferone (4-MU) was used to screen the inhibition potential of triiodothyronine (T3) and thyroxine (T4) on the activity of various UGT isoforms...
March 13, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28285325/mglu1-receptor-as-a-drug-target-for-treatment-of-substance-use-disorders-time-to-gather-stones-together
#10
REVIEW
Olga A Dravolina, Edwin Zvartau, Wojciech Danysz, Anton Y Bespalov
Modulation of the mGlu1 receptor was repeatedly shown to inhibit various phenomena associated with exposure to abused drugs. Efficacy in preclinical models was observed with both positive and negative allosteric modulators (PAMs and NAMs, respectively) using essentially non-overlapping sets of experimental methods. Taken together, these data indicate that the mGlu1 receptor certainly plays a significant role in the plasticity triggered by the exposure to abused drugs and is involved in the maintenance of drug-seeking and drug-taking behaviors...
March 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28281256/label-free-biosensors-based-on-bimodal-waveguide-bimw-interferometers
#11
Sonia Herranz, Adrián Fernández Gavela, Laura M Lechuga
The bimodal waveguide (BiMW) sensor is a novel common path interferometric transducer based on the evanescent field detection principle, which in combination with a bio-recognition element allows the direct detection of biomolecular interactions in a label-free scheme. Due to its inherent high sensitivity it has great potential to become a powerful analytical tool for monitoring substances of interest in areas such as environmental control, medical diagnostics and food safety, among others. The BiMW sensor is fabricated using standard silicon-based technology allowing cost-effective production, and meeting the requirements of portability and disposability necessary for implementation in a point-of-care (POC) setting...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28281248/two-dimensional-surface-plasmon-resonance-imaging-system-for-cellular-analysis
#12
Tanveer Ahmad Mir, Hiroaki Shinohara
Optical biosensors based on surface plasmon resonance (SPR) phenomenon have received a great deal of attention in cellular analysis applications. Sensitive and high-resolution SPR imaging (SPRi) platforms are very useful for real-time monitoring and measurement of individual cell responses to various exogenous substances. In cellular analysis, mainstream SPR-based sensors have potential for investigations of cell responses under ambient conditions. Evaluations that account only for the average response of cell monolayers mask the understanding of precise cell-molecular interactions or intracellular reactions at the level of individual cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28279880/electrobioremediation-of-oil-spills
#13
REVIEW
Matteo Daghio, Federico Aulenta, Eleni Vaiopoulou, Andrea Franzetti, Jan B A Arends, Angela Sherry, Ana Suárez-Suárez, Ian M Head, Giuseppina Bestetti, Korneel Rabaey
Annually, thousands of oil spills occur across the globe. As a result, petroleum substances and petrochemical compounds are widespread contaminants causing concern due to their toxicity and recalcitrance. Many remediation strategies have been developed using both physicochemical and biological approaches. Biological strategies are most benign, aiming to enhance microbial metabolic activities by supplying limiting inorganic nutrients, electron acceptors or donors, thus stimulating oxidation or reduction of contaminants...
February 20, 2017: Water Research
https://www.readbyqxmd.com/read/28279835/organic-wastes-as-soil-amendments-effects-assessment-towards-soil-invertebrates
#14
Mathieu Renaud, Sónia Chelinho, Paula Alvarenga, Clarisse Mourinha, Patrícia Palma, José Paulo Sousa, Tiago Natal-da-Luz
Using organic wastes, as soil amendments, is an important alternative to landfilling with benefits to soil structure, water retention, soil nutrient and organic matter concentrations. However, this practice should be monitored for its environmental risk due to the frequent presence, of noxious substances to soil organisms. To evaluate the potential of eight organic wastes with different origins, as soil amendments, reproduction tests with four soil invertebrate species (Folsomia candida, Enchytraeus crypticus, Hypoaspis aculeifer, Eisenia fetida) were performed using gradients of soil-waste mixtures...
February 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28279159/changes-in-prevalence-of-psychotropic-drug-use-and-alcohol-consumption-among-the-elderly-in-germany-results-of-two-national-health-interview-and-examination-surveys-1997-99-and-2008-11
#15
Ingrid-Katharina Wolf, Yong Du, Hildtraud Knopf
BACKGROUND: Psychotropic drug use and alcohol consumption among older adults need to be monitored over time as their use or combined use bears risks of harms. Representative data on changes in prevalence, patterns and co-relates of substance use are lacking in Germany. METHODS: Participants were older adults (60-79 years) from two German National Health Surveys: 1997-99 (GNHIES98, N = 1,606) and 2008-11 (DEGS1, N = 2,501). Included were drugs acting on the nervous system used during the last 7 days...
March 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28278127/veterinary-drugs-residues-a-review-of-the-latest-analytical-research-on-sample-preparation-and-lc-ms-based-methods
#16
Lucia Mainero Rocca, Alessandra Gentili, Virginia Pérez-Fernández, Pierpaolo Tomai
The world population is increasing day by day and as a result there is a growing demand for food. Inevitably livestock and crops become intensive and require an increasing use of adjuvants. Even the logic of the extreme profit acts as an engine and often leads to fraudulent use of drugs, pesticides etc. Particularly, veterinary drugs can pose a real risk to human health if their residues are allowed to enter the food chain. Parent drugs and their metabolites can occur in foodstuffs individually or as multicomponent mixtures with enhanced adverse effects...
February 22, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28272837/the-effect-of-buckwheat-hull-extract-on-lipid-oxidation-in-frozen-stored-meat-products
#17
Marzanna Hęś, Artur Szwengiel, Krzysztof Dziedzic, Joanna Le Thanh-Blicharz, Dominik Kmiecik, Danuta Górecka
This study investigated the effect of antioxidants on lipid stability of frozen-stored meat products. Buckwheat hull extract was used to enrich fried meatballs made from ground pork. During 180-d storage of meat products, lipid oxidation (peroxide and 2-thiobarbituric acid reactive substances [TBARS] value) was periodically monitored. The results were compared with butylated hydroxytoluene (BHT). The addition of antioxidants decreased lipid oxidation in stored meatballs. The highest ability to control peroxide and TBARS values was demonstrated for buckwheat hull extract...
March 8, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28268373/automated-transepithelial-electrical-resistance-measurements-of-the-epiderm-reconstructed-human-epidermis-model
#18
Frank A Alexander, Joachim Wiest
Understanding the effect of exogenous substances on human skin is critical for toxicology assessment. To address this, numerous artificial models of the topmost layer of human skin, so-called reconstructed human epidermis (RhE), have been created in an attempt to produce a clear analogue for testing. Unfortunately, current testing modalities still rely on endpoint assays and are not capable of monitoring time-resolved changes in barrier function without using numerous redundant samples. In this work, a novel, time-resolved approach is realized by monitoring the transepithelial electrical resistance (TEER) of MatTek EpiDerm® reconstructed human epidermis model, utilizing an automated protocol with the Intelligent Mobile Lab for in vitro diagnostics (IMOLA-IVD)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267790/cigarette-smoking-is-associated-with-high-hiv-viral-load-among-adults-presenting-for-antiretroviral-therapy-in-vietnam
#19
Todd M Pollack, Hao T Duong, Thuy T Pham, Cuong D Do, Donn Colby
High HIV viral load (VL >100,000 cp/ml) is associated with increased HIV transmission risk, faster progression to AIDS, and reduced response to some antiretroviral regimens. To better understand factors associated with high VL, we examined characteristics of patients presenting for treatment in Hanoi, Vietnam. We examined baseline data from the Viral Load Monitoring in Vietnam Study, a randomized controlled trial of routine VL monitoring in a population starting antiretroviral therapy (ART) at a clinic in Hanoi...
2017: PloS One
https://www.readbyqxmd.com/read/28267693/predictors-of-in-hospital-postoperative-opioid-overdose-after-major-elective-operations-a-nationally-representative-cohort-study
#20
Christy E Cauley, Geoffrey Anderson, Alex B Haynes, Mariano Menendez, Brian T Bateman, Karim Ladha
OBJECTIVE: The aim of this study was to describe national trends and outcomes of in-hospital postoperative opioid overdose (OD) and identify predictors of postoperative OD. SUMMARY OF BACKGROUND DATA: In 2000, the Joint Commission recommended making pain the 5th vital sign, increasing the focus on postoperative pain control. However, the benefits of pain management must be weighed against the potentially lethal risk of opioid OD. METHODS: This is a retrospective multi-institutional cohort study of patients undergoing 1 of 6 major elective inpatient operation from 2002 to 2011 using the Nationwide Inpatient Sample, an approximately 20% representative sample of all United States hospital admissions...
April 2017: Annals of Surgery
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