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https://www.readbyqxmd.com/read/28528261/perfluoroalkylated-acids-in-the-eggs-of-great-tits-parus-major-near-a-fluorochemical-plant-in-flanders-belgium
#1
Thimo Groffen, Ana Lopez-Antia, Wendy D'Hollander, Els Prinsen, Marcel Eens, Lieven Bervoets
Perfluoroalkyl acids (PFAAs) are highly persistent substances which have been detected in wildlife around the world, including birds. Although bird eggs have often been used to determine and monitor PFAAs levels in the marine environment, this has rarely been done in the terrestrial environment. In the present study we examined the concentrations and composition profile of 12 PFAAs (4 perfluoroalkyl sulfonic acids (PFSAs) and 8 perfluoroalkyl carboxylic acids (PFCAs) in the eggs of great tits (Parus major) collected at a fluorochemical plant and in three other areas, representing a gradient in distance from the pollution source (from 1 to 70 km), in Antwerp, Belgium...
May 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28519244/neonatal-abstinence-syndrome-update-on-diagnostic-and-therapeutic-strategies
#2
Genny Raffaeli, Giacomo Cavallaro, K Karel Allegaert, Enno Diederik Wildschut, Monica Fumagalli, Massimo Agosti, Dick Tibboel, Fabio Mosca
Substance use among pregnant women is a major public health issue. Both prescription opioid use and illicit opioid abuse have increased dramatically in recent years. Prolonged in utero drug exposure may result in neonatal abstinence syndrome (NAS), an acute multisystemic clinical entity that occurs in the first days of life. This syndrome is caused by abrupt discontinuation of fetal exposure to licit or illicit drugs chronically consumed by the mother during pregnancy and transmitted to the fetus through the placenta...
May 18, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28517032/novel-psychoactive-substance-consumption-is-more-represented-in-bipolar-disorder-than-in-psychotic-disorders-a-multicenter-observational-study
#3
Tiziano Acciavatti, Matteo Lupi, Rita Santacroce, Andrea Aguglia, Luigi Attademo, Laura Bandini, Paola Ciambrone, Giulia Lisi, Giovanni Migliarese, Federica Pinna, Diego Quattrone, Michele Ribolsi, Maria Salvina Signorelli, Salvatore Calò, Fabrizio Schifano, Massimo di Giannantonio, Giovanni Martinotti
OBJECTIVE: Comorbidities between psychiatric diseases and use of traditional substances of abuse are common. Nevertheless, there are few data regarding the use of novel psychoactive substances (NPS) among psychiatric patients. Aim of this multicentre survey is to investigate the consumption of a number of psychoactive substances in a young psychiatric sample. METHODS: Between December 2013 and September 2015, a questionnaire was administered in 10 Italian psychiatric care facilities to a sample of 671 patients, aged 18-26 (mean age 22...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28512369/-nanopesticides-light-or-dark-side-of-the-force
#4
REVIEW
Magdalena Matysiak, Marcin Kruszewski, Lucyna Kapka-Skrzypczak
Nanotechnology has been used in many branches of industry, including agriculture, where nanomaterials are used as carriers of chemical plant protection compounds, as well as active ingredients. Meanwhile, the effects of nanopesticides exposure on the human body are unknown. Due to their occupation, farmers should be particularly monitored. This paper summarizes the use of nanoparticles in agriculture, the route of potential exposure for agricultural workers and the current state of knowledge of nanopesticides toxicity to mammalian cells...
May 16, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28509940/medico-legal-assessment-of-methamphetamine-and-amphetamine-serum-concentrations-what-can-we-learn-from-survived-intoxications
#5
Marco Weber, Rüdiger Lessig, Carolin Richter, Axel P Ritter, Ilona Weiß
Medico-legal experts are increasingly enlisted to assess the methamphetamine and amphetamine serum concentrations after a criminal offense. However, since criminal users rarely provide useful information to medico-legal experts regarding the substances abused, when the substance(s) was/were used, dose of ingestion tools are needed to interpret the analytical data, which can be used as objective evidence in such cases. A comparative series of methamphetamine and amphetamine serum concentrations were used to analyze the frequency of concentrations, to determine methamphetamine/amphetamine concentration ratios, and prove them as a tool to distinguish pure methamphetamine from mixed amphetamine/methamphetamine ingestion...
May 16, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28500604/a-primer-to-angiotensin-peptide-isolation-stability-and-analysis-by-nano-liquid-chromatography-with-mass-detection
#6
Mariola Olkowicz, Stefan Chlopicki, Ryszard T Smolenski
The renin-angiotensin system (RAS) is an important element of cardiovascular and renal physiology and targeting the RAS by renin inhibitors, angiotensin (Ang) converting enzyme (ACE) inhibitors and Ang II type 1 receptor antagonists is effective in the treatment of hypertension, heart failure, and atherosclerosis. Quantification of Ang peptides is critical to establish the status of the RAS, but it is challenging due to low Ang peptides concentrations (fmol/mL or fmol/g), abundance of interfering substances, post sampling conversions, and difficulties with the specificity of the assay...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28493314/use-of-lc-hrms-in-full-scan-xic-mode-for-multi-analyte-urine-drug-testing-a-step-towards-a-black-box-solution
#7
Niclas Nikolai Stephanson, Patrick Signell, Anders Helander, Olof Beck
The influx of new psychoactive substances (NPS) has created a need for improved methods for drug testing in toxicology laboratories. The aim of this work was to design, validate and apply a multi-analyte liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for screening of 148 target analytes belonging to the NPS class, plant alkaloids and new psychoactive therapeutic drugs. The analytical method used a five-fold dilution of urine with 9 deuterated internal standards and injection of 2 μL...
May 10, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28490022/concurrent-treatment-with-prolonged-exposure-for-co-occurring-full-or-subthreshold-posttraumatic-stress-disorder-and-substance-use-disorders-a-randomized-clinical-trial
#8
Lesia M Ruglass, Teresa Lopez-Castro, Santiago Papini, Therese Killeen, Sudie E Back, Denise A Hien
BACKGROUND: To test whether an integrated prolonged exposure (PE) approach could address posttraumatic stress disorder (PTSD) symptoms effectively in individuals with co-occurring substance use disorders (SUD), we compared concurrent treatment of PTSD and SUD using PE (COPE) to relapse prevention therapy (RPT) for SUD and an active monitoring control group (AMCG). METHODS: We conducted a randomized 12-week trial with participants (n = 110; 64% males; 59% African Americans) who met Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision criteria for full or subthreshold PTSD and SUD...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28482460/exploring-the-presence-of-pollutants-at-sea-monitoring-heavy-metals-and-pesticides-in-loggerhead-turtles-caretta-caretta-from-the-western-mediterranean
#9
O Novillo, J F Pertusa, J Tomás
Marine turtles are considered good sentinel species for environmental assessment because of their long lifespan, feeding ecology, habitat use and migratory nature. In the present study, we assessed presence of cadmium, lead and mercury, together with organic pollutants, both in fat and muscle tissue of 25 stranded loggerhead turtles (Caretta caretta) stranded along the Valencian Community coast (East Spain) (43.7±13.5cm). Mean concentrations of Cd, Pb and Hg were 0.04μg/g w.w., 0.09μg/g w.w. and 0.03μg/g w...
May 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28480492/prioritization-of-substances-for-national-ambient-monitoring-of-sediment-in-switzerland
#10
Maria Del Carmen Casado-Martinez, Michel Wildi, Benoit J D Ferrari, Inge Werner
In Switzerland, surface waters are protected by the Swiss Water Protection Ordinance (OEaux; OFEV 1998), which stipulates that the water quality shall be such that the water, suspended matter, and sediments contain no persistent synthetic substances to ensure the protection of aquatic life. Local agencies are in charge of water quality monitoring, using a set of validated methods. Several lists of priority substances have been developed for aquatic microcontaminants for surface water monitoring but not for sediments...
May 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28480483/lifetime-eating-disorder-comorbidity-associated-with-delayed-depressive-recovery-in-bipolar-disorder
#11
Danielle R Balzafiore, Natalie L Rasgon, Laura D Yuen, Saloni Shah, Hyun Kim, Kathryn C Goffin, Shefali Miller, Po W Wang, Terence A Ketter
BACKGROUND: Although eating disorders (EDs) are common in bipolar disorder (BD), little is known regarding their longitudinal consequences. We assessed prevalence, clinical correlates, and longitudinal depressive severity in BD patients with vs. without EDs. METHODS: Outpatients referred to Stanford University BD Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) affective disorders evaluation, and while receiving naturalistic treatment for up to 2 years, were monitored with the STEP-BD clinical monitoring form...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28476319/simultaneous-determination-of-components-with-wide-polarity-and-content-ranges-in-cistanche-tubulosa-using-serially-coupled-reverse-phase-hydrophilic-interaction-chromatography-tandem-mass-spectrometry
#12
Yu Yan, Qingqing Song, Xiaojia Chen, Jun Li, Peng Li, Yitao Wang, Tongxiang Liu, Yuelin Song, Pengfei Tu
To meet the demands from plant physiologists and pharmacognosists, sustainable efforts are being devoted by the analytical chemists from all over the world to search an approach being capable of simultaneously monitoring primary along with secondary metabolites. The key technical bottlenecks currently lie at affording satisfactory chromatographic and spectrometric performances for both hydrophilic and hydrophobic substances that span a great content range. Herein, reverse phase liquid chromatography was directly coupled with hydrophilic interaction chromatography, namely RPLC-HILIC, to integrate their merits, whereas dilution pumps were employed to tackle the mismatching for the mobile phase between them...
June 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28472407/traumatic-brain-injury-and-attempted-suicide-among-veterans-of-the-wars-in-iraq-and-afghanistan
#13
Jennifer R Fonda, Lisa Fredman, Susan B Brogly, Regina E McGlinchey, William P Milberg, Jaimie L Gradus
Studies of the association between traumatic brain injury (TBI) and suicide attempt have yielded conflicting results. Furthermore, no studies have examined the possible mediating role of common comorbid psychiatric conditions in this association. This study used Veterans Affairs registry data to evaluate the associations between deployment-related TBI, psychiatric diagnoses, and attempted suicide among 273,591 veterans deployed in support of Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn, and who received care from the Department of Veterans Affairs during 2007-2012...
May 3, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28468125/pesticide-mixtures-in-the-swedish-streams-environmental-risks-contributions-of-individual-compounds-and-consequences-of-single-substance-oriented-risk-mitigation
#14
Mikael Gustavsson, Jenny Kreuger, Mirco Bundschuh, Thomas Backhaus
This paper presents the ecotoxicological assessment and environmental risk evaluation of complex pesticide mixtures occurring in freshwater ecosystems in southern Sweden. The evaluation is based on exposure data collected between 2002 and 2013 by the Swedish pesticide monitoring program and includes 1308 individual samples, detecting mixtures of up to 53 pesticides (modal=8). Pesticide mixture risks were evaluated using three different scenarios for non-detects (best-case, worst-case and using the Kaplan-Meier method)...
April 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28464353/neurokinin-1-receptor-blocker-cp-99%C3%A2-994-improved-emesis-induced-by-cisplatin-via-regulating-the-activity-of-gastric-distention-responsive-neurons-in-the-dorsal-motor-nucleus-of-vagus-and-enhancing-gastric-motility-in-rats
#15
X Sun, L Xu, F Guo, W Luo, S Gao, X Luan
BACKGROUND: Nowadays, chemotherapy induced nausea and vomiting (CINV) is still common in patients with cancer. It was reported that substance P mediated CINV via neurokinin-1 (NK1 ) receptor and antagonists of NK1 receptor has been proved useful for treating CINV but the mechanism are not fully understood. This study aimed to examine the role of NK1 receptor blocker, CP-99 994, when administrated into dorsal motor nucleus of vagus (DMNV), on the cisplatin-induced emesis in rats and the possible mechanism...
May 2, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28463891/neuro-magnetic-resonance-imaging-in-hand-foot-and-mouth-disease-finding-in-412-patients-and-prognostic-features
#16
Zhou-Yang Lian, He-Hong Li, Bin Zhang, Yu-Hao Dong, Wu-Xu Deng, Jing Liu, Xiao-Ning Luo, Biao Huang, Chang-Hong Liang, Shui-Xing Zhang
PURPOSE: The aims of this study were to describe the neuroimaging findings in hand, foot, and mouth disease and determine those who may provide prognosis. MATERIAL AND METHODS: Magnetic resonance imaging scans in 412 severe hand, foot, and mouth disease between 2009 and 2014 were retrospectively evaluated. The patients who had the neurological signs were followed for 6 months to 1 year. According to the good or poor prognosis, 2 groups were categorized. The incidence of lesions in different sites between the 2 groups was compared, and multivariate analysis was used to look for risk factors...
April 21, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28463852/substance-use-among-nurses-and-nursing-students-a-joint-position-statement-of-the-emergency-nurses-association-and-the-international-nurses-society-on-addictions
#17
Stephen Strobbe, Melanie Crowley
Alcohol and other substance use by nurses potentially places patients, the public, and nurses themselves at risk for serious injury or death. Nursing students are also at risk for problems related to substance use. When viewed and treated as a chronic medical illness, treatment outcomes for substance use disorders are comparable with those of other diseases and can result in lasting benefits. Professional monitoring programs that employ an alternative-to-discipline approach have been shown to be effective in the treatment of health professionals with substance use disorders and are considered a standard for recovery, with high rates of completion and return to practice...
May 2, 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/28463061/exercise-protects-against-insulin-dependent-diabetes-induced-osteoarthritis-in-rats-a-scanning-electron-microscopy-study
#18
Fahaid Al-Hashem, Abbas O El Karib, Ismaeel Bin-Jaliah, Mohammad Dallak, Hussein F Sakr, Refaat A Eid, Mohamed Samir A Zaki, Mariam Al-Shamsi, Mohamed A Haidara, Bahjat Al-Ani
We tested the hypothesis that swim exercise can protect the articular cartilage from damages induced secondary to insulin-dependent diabetes mellitus in rats using the scanning electron microscopy and to monitor the blood levels of oxidative and antioxidative stress biomarkers that are known to be modulated in osteoarthritis (OA). A profound damage to the cartilage was observed in the diabetic rats. Our findings also show that swim exercise protects the knee joints from damage induced by diabetes as well as significantly inhibiting OA-induced upregulation of thiobarbituric acid reactive substances (TBARS) and tumor necrosis factor alpha (TNF-α) and augmented superoxide dismutase (SOD) inhibition by OA...
May 2, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28459969/reports-of-adverse-events-associated-with-use-of-novel-psychoactive-substances-2013-2016-a-review
#19
Barry K Logan, Amanda L A Mohr, Melissa Friscia, Alex J Krotulski, Donna M Papsun, Sherri L Kacinko, Jeri D Ropero-Miller, Marilyn A Huestis
Novel psychoactive substances (NPS) represent significant analytical and interpretive challenges to forensic and clinical toxicologists. Timely access to case reports and reports of adverse incidents of impairment or toxicity is imperative to clinical diagnosis and treatment, as well as to interpretation of forensic results. Delays in identifying the presence of a novel intoxicating agent have significant consequences for public health and public safety. Adverse effects of intoxications with novel cannabinoids, stimulants, hallucinogens, benzodiazepines and opioids spanning January 2013 through December 2016 as reported in emergency departments, death investigations, impaired driving cases and other forensic contexts are the subject of this review...
April 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28456060/sample-treatment-procedures-for-environmental-sensing-and-biosensing
#20
REVIEW
Josep Sanchís, Marta Llorca, Damià Barceló, Marinella Farré
During the last years, a lot of efforts have been put into developing novel sensors and biosensors systems for monitoring the occurrence of emerging pollutants in the environment. These analyses are often challenging because of the variety of physico-chemical properties of these substances, the extremely diluted concentrations at which they can be found, and the intrinsic complexity of environmental matrices. In order to improve the (bio)sensors' performance, preconcentration/pretreatment techniques may be implemented...
April 26, 2017: Current Opinion in Biotechnology
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