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https://www.readbyqxmd.com/read/28107715/metabolical-shifts-towards-alternative-btex-biodegradation-intermediates-induced-by-perfluorinated-compounds-in-firefighting-foams
#1
Renato Nallin Montagnolli, Paulo Renato Matos Lopes, Jaqueline Matos Cruz, Marina Turini Claro, Gabriela Mercuri Quiterio, Ederio Dino Bidoia
The type and concentration of perfluorinated compounds (PFCs) can induce different types of enzymes and promote alternate patterns of BTEX transformation. However, it is not known how the presence of active fluorocarbon-degrading microbial populations affects the transformation of BTEX. In addition to chemical analysis at the molecular level, our research approached the aqueous film forming fire-fighting foams (AFFF) and BTEX co-contamination at a large-scale with respirometers to quantify the total microbial metabolism of soil via CO2 output levels...
December 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/28104414/dissolution-failure-of-solid-oral-drug-products-in-field-alert-reports
#2
Dajun Sun, Meng Hu, Mark Browning, Rick L Friedman, Wenlei Jiang, Liang Zhao, Hong Wen
From 2005 to 2014, 370 data entries of dissolution failures of solid oral drug products were assessed with respect to the solubility of drug substances, dosage forms (immediate release (IR) vs. modified release (MR)), and manufacturers (brand-name vs. generic). The study results show that the solubility of drug substances does not play a significant role in dissolution failures; however, MR drug products fail dissolution tests more frequently than IR drug products. When multiple variables were analyzed simultaneously, poorly water-soluble IR drug products failed the most dissolution tests, followed by poorly soluble MR drug products and very soluble MR drug products...
January 16, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28103698/histamine-applied-topically-to-the-nasal-mucosa-increases-the-transmucosal-nitrous-oxide-exchange-for-the-middle-ear
#3
Miriam S Teixeira, Cuneyt M Alper, Brian S Martin, Selma Cetin, Jenna A El-Wagaa, William J Doyle
OBJECTIVE: Determine if the middle ear transmucosal nitrous oxide (N2O) exchange rate is affected by nasal inflammation caused by topical application of histamine. METHODS: In a randomized, double-blind, crossover study, 20 adults were challenged intranasally with histamine (5 mg) and placebo on separate occasions. At each session, the subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and 100% O2 for 10 minutes...
January 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28101955/prescription-drug-monitoring-programs-produce-a-limited-impact-on-painkiller-prescribing-in-medicare-part-d
#4
Courtney R Yarbrough
OBJECTIVE: To measure the impact of prescription drug monitoring programs (PDMPs) on prescribing of opioid and nonopioid painkillers. DATA SOURCE: 2010-2013 physician-level Medicare Part D prescribing data released by the Centers for Medicare and Medicaid Services and Propublica. STUDY DESIGN: Using difference-in-differences models with physician-level fixed effects, the study compares prescribing in states with and without PDMPs for opioid and nonopioid analgesics, oxycodone, hydrocodone, and opioids by controlled substances Schedules II-IV...
January 18, 2017: Health Services Research
https://www.readbyqxmd.com/read/28101189/inhibition-of-cytoskeletal-protein-carbonylation-may-protect-against-oxidative-damage-in-traumatic-brain-injury
#5
Qiusheng Zhang, Meng Zhang, Xianjian Huang, Xiaojia Liu, Weiping Li
Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates protracted neuronal dysfunction and remodeling. Cytoskeletal proteins are known to be carbonylated under oxidative stress; however, the complex molecular and cellular mechanisms of cytoskeletal protein carbonylation remain poorly understood. In the present study, the expression levels of glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) were investigated in PC12 cells treated with H2O2. Western blot analysis was used to monitor the carbonylation levels of β-actin and β-tubulin...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28093274/a-direct-quantitative-pcr-based-measurement-of-herpes-simplex-virus-susceptibility-to-antiviral-drugs-and-neutralizing-antibodies
#6
Dezső P Virók, Ildikó Eszik, Tímea Mosolygó, Kamil Önder, Valéria Endrész, Katalin Burián
Herpes simplex viruses (HSV) are common human pathogens that can cause painful but benign manifestations and recurrent complaints, but can also cause significant morbidity and mortality on infection of the eye or brain and with disseminated infection of an immunosuppressed patient or a neonate. HSV growth inhibition measurement by plaque or yield reduction is a key task in the development of novel antiviral compounds but the manual methods are very labour intensive. The sensitive and specific PCR technology could be an effective method for quantitation of HSV DNA related to virus replication; however the currently described PCR approaches have a major limitation, namely the requirement of purification of DNA from the infected cells...
January 13, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28092435/microbial-biotransformation-of-five-pyrrolidinophenone-type-psychoactive-substances-in-wastewater-and-a-wastewater-isolated-pseudomonas-putida-strain
#7
Marie Mardal, Markus Bischoff, María Ibáñez, Ulla Ruffing, Félix Hernández, Markus R Meyer
Wastewater-based epidemiology (WBE) employs the analysis of wastewater to detect and quantify drug use and discharge within a community. In this work, transformation products (TP) by microbes in the environment were identified after incubations in wastewater and an isolated microbial strain. The microbial strain was isolated from an enrichment culture of wastewater supplemented with 3,4-methylenedioxy-pyrovalerone, and identified by matrix assisted laser desorption - time of flight mass spectrometry as Pseudomonas putida (P...
January 16, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28091530/the-autofluorescence-characteristics-of-bacterial-intracellular-and-extracellular-substances-during-the-operation-of-anammox-reactor
#8
Xiaolin Hou, Sitong Liu, Ying Feng
Anammox is a cost-effective process to treat nitrogenous wastewater. In this work, excitation-emission matrix (EEM) fluorescence spectroscopy was used to characterize the intracellular and extracellular substances of anammox sludge during reactor operation of 276 days. Four main fluorophores were identified from the intracellular substances. Two main protein-like fluorophores were identified from the extracellular substances. Correlation analysis revealed that intracellular 420 peak and humic-like peak had strong correlation with nitrogen removal rate...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090277/anti-quorum-sensing-activity-of-substances-isolated-from-wild-berry-associated-bacteria
#9
Suha M Abudoleh, Adel M Mahasneh
BACKGROUND: Quorum Sensing (QS) is a mechanism used by bacteria to determine their physiological activities and coordinate gene expression based on cell to cell signaling. Many bacterial physiological functions are under the regulation of quorum sensing such as virulence, luminescence, motility, sporulation and biofilm formation. The aim of the present study was to isolate and characterize Quorum Sensing Inhibitory (QSI) substances from epiphytic bacteria residing on wild berries surfaces...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28080082/parenting-and-later-substance-use-among-mexican-origin-youth-moderation-by-preference-for-a-common-language
#10
Thomas J Schofield, Rosa I Toro, Ross D Parke, Jeffrey T Cookston, William V Fabricius, Scott Coltrane
The primary goal of the current study was to test whether parent and adolescent preference for a common language moderates the association between parenting and rank-order change over time in offspring substance use. A sample of Mexican-origin 7th-grade adolescents (Mage = 12.5 years, N = 194, 52% female) was measured longitudinally on use of tobacco, alcohol, and marijuana. Mothers, fathers, and adolescents all reported on consistent discipline and monitoring of adolescents. Both consistent discipline and monitoring predicted relative decreases in substance use into early adulthood but only among parent-offspring dyads who expressed preference for the same language (either English or Spanish)...
January 12, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28074561/substance-use-outcomes-of-patients-served-by-a-large-us-implementation-of-screening-brief-intervention-and-referral-to-treatment-sbirt
#11
Arnie Aldridge, Robyn Linford, Jeremy Bray
AIMS: To estimate changes in the substance use behaviors of patients who received services as part of the US Substance Abuse and Mental Health Services Administration's (SAMHSA) Screening, Brief Intervention and Referral to Treatment (SBIRT) grant program. METHODS: We use a pre-post design and performance monitoring data collected by SBIRT organizations. For a sample of 17 575 patients, we compare pre-SBIRT substance use with substance use 6 months after receipt of SBIRT services...
February 2017: Addiction
https://www.readbyqxmd.com/read/28072812/is-kratom-the-new-legal-high-on-the-block-the-case-of-an-emerging-opioid-receptor-agonist-with-substance-abuse-potential
#12
George C Chang-Chien, Charles A Odonkor, Prin Amorapanth
Kratom is an unscheduled opioid receptor agonist that comes in the form of dietary supplements currently being abused by chronic pain patients on prescription opioids. Active alkaloids isolated from kratom such as mitragynine and 7-hydroxymitragynine are thought to act on mu- and delta-opioid receptors as well as alpha-2 adrenergic and 5-HT2A receptors. Animal studies suggest that kratom may be more potent than morphine. Consequently, kratom consumption produces analgesic and euphoric feelings among users. In particular, some chronic pain patients on opioids take kratom to counteract the effects of opioid withdrawal...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072644/use-of-an-analog-scale-in-the-treatment-of-patients-with-bipolar-disorder-to-optimize-assessment-and-clinical-outcome
#13
Sheldon H Preskorn
This column explains how a clinician can use an analog scale for patients with bipolar disorder: (1) to elucidate the course of the illness in a specific patient and (2) to assess response to treatment. This scale complements other standardized rating scales, such as the Young Mania Rating Scale, because its anchors are tailored to each specific patient in terms of the worst depressive or hypomanic/manic episode (ie, a -10 or +10, respectively) the person has ever experienced. The scale also allows clinicians to track how the individual patient's episodes have responded to treatment in the past, including whether the patient ever has achieved a full remission (ie, score of 0) following the initial onset of the disorder...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28070217/health-systems-context-s-for-integrating-mental-health-into-primary-health-care-in-six-emerald-countries-a-situation-analysis
#14
REVIEW
James Mugisha, Jibril Abdulmalik, Charlotte Hanlon, Inge Petersen, Crick Lund, Nawaraj Upadhaya, Shalini Ahuja, Rahul Shidhaye, Ntokozo Mntambo, Atalay Alem, Oye Gureje, Fred Kigozi
BACKGROUND: Mental, neurological and substance use disorders contribute to a significant proportion of the world's disease burden, including in low and middle income countries (LMICs). In this study, we focused on the health systems required to support integration of mental health into primary health care (PHC) in Ethiopia, India, Nepal, Nigeria, South Africa and Uganda. METHODS: A checklist guided by the World Health Organization Assessment Instrument for Mental Health Systems (WHO-AIMS) was developed and was used for data collection in each of the six countries participating in the Emerging mental health systems in low and middle-income countries (Emerald) research consortium...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28069452/the-novel-technique-of-vapor-pressure-analysis-to-monitor-the-enzymatic-degradation-of-phb-by-hplc-chromatography
#15
Péter Polyák, Piroska Rácz, Péter Rózsa, Gergely N Nagy, Beáta G Vértessy, Béla Pukánszky
A novel method was introduced for the quantitative determination of substances in aqueous solutions by using the evaporative light scattering (ELS) detector of a high performance liquid chromatograph (HPLC). The principle of the measurement is the different equilibrium vapor pressure of the solvent and the analyte resulting in decreasing evaporation rate, larger droplets and stronger signal with increasing concentration. The new technique based on vapor pressure analysis was validated with traditional UV-Vis detection carried out with a diode array detector (DAD)...
January 6, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28068536/application-of-uv-absorbance-and-fluorescence-indicators-to-assess-the-formation-of-biodegradable-dissolved-organic-carbon-and-bromate-during-ozonation
#16
Wen-Tao Li, Meng-Jie Cao, Tessora Young, Barbara Ruffino, Michael Dodd, Ai-Min Li, Gregory Korshin
This study examined the significance of changes of UV absorbance and fluorescence of dissolved organic matter (DOM) as surrogate indicators for assessing the formation of bromate and biodegradable dissolved organic carbon (BDOC) during the ozonation of surface water and wastewater effluent. Spectroscopic monitoring was carried out using benchtop UV/Vis and fluorescence spectrophotometers and a newly developed miniature LED UV/fluorescence sensor capable of rapidly measuring UVA280 and protein-like and humic-like fluorescence...
January 3, 2017: Water Research
https://www.readbyqxmd.com/read/28067776/sensitivity-of-quantitative-signal-detection-in-regards-to-pharmacological-neuroenhancement
#17
Maximilian Gahr, Bernhard J Connemann, Carlos Schönfeldt-Lecuona, René Zeiss
Pharmacological neuroenhancement (PNE) is a form of abuse and has not yet been addressed by methods of pharmacovigilance. In the present study, we tested if quantitative signal detection may be sensitive in regards to PNE. We evaluated the risk of drug abuse and dependence (DAAD) related to substances that are known to be used for PNE and divided this group into agents with (methylphenidate) and without a known abuse potential outside the field of PNE (atomoxetine, modafinil, acetylcholine esterase inhibitors, and memantine)...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28067757/family-medicine-physicians-with-substance-use-disorder-a-5-year-outcome-study
#18
John S Rose, Michael D Campbell, Peter Yellowlees, Gregory E Skipper, Robert L DuPont
OBJECTIVES: There is little published evidence on how well family medicine physicians (FMPs) with substance use disorder (SUD) perform in Physician Health Programs (PHPs). We examined outcomes for FMP compared with non-FMP physicians. METHODS: This study utilized data from a 5-year, longitudinal, cohort study involving 904 physicians with diagnoses of SUD consecutively admitted to one of 16 state PHPs between 1995 and 2001. We compared 175 FMPs to 687 other physicians...
January 6, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28063035/monitoring-skin-dendritic-cells-in-steady-state-and-inflammation-by-immunofluorescence-microscopy-and-flow-cytometry
#19
Julia L Ober-Blöbaum, Daniela Ortner, Bernhard Haid, Anna Brand, Christoph Tripp, Björn E Clausen, Patrizia Stoitzner
Skin dendritic cells (DC) are strategically positioned at the body's second largest epithelial border to the environment. Hence they are the first antigen presenting cells that encounter invading pathogens and environmental antigens, including contact sensitizers and carcinogens penetrating the skin. Moreover, DC have the unique ability to induce immunity or tolerance and thus take center stage in regulating innate and adaptive immune responses. Skin DC can be divided into several phenotypically and functionally distinct subtypes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28062104/assessment-of-a-novel-device-for-onsite-integrative-large-volume-solid-phase-extraction-of-water-samples-to-enable-a-comprehensive-chemical-and-effect-based-analysis
#20
Tobias Schulze, Marijan Ahel, Jörg Ahlheim, Selim Aït-Aïssa, François Brion, Carolina Di Paolo, Jean Froment, Anita O Hidasi, Juliane Hollender, Henner Hollert, Meng Hu, Anett Kloß, Sanja Koprivica, Martin Krauss, Melis Muz, Peter Oswald, Margit Petre, Jennifer E Schollée, Thomas-Benjamin Seiler, Ying Shao, Jaroslav Slobodnik, Manoj Sonavane, Marc J-F Suter, Knut Erik Tollefsen, Zuzana Tousova, Karl-Heinz Walz, Werner Brack
The implementation of targeted and nontargeted chemical screening analysis in combination with in vitro and organism-level bioassays is a prerequisite for a more holistic monitoring of water quality in the future. For chemical analysis, little or no sample enrichment is often sufficient, while bioanalysis often requires larger sample volumes at a certain enrichment factor for conducting comprehensive bioassays on different endpoints or further effect-directed analysis (EDA). To avoid logistic and technical issues related to the storage and transport of large volumes of water, sampling would benefit greatly from onsite extraction...
January 3, 2017: Science of the Total Environment
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