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https://www.readbyqxmd.com/read/28326890/functional-and-molecular-correlates-following-single-and-repeated-rat-closed-head-concussion-indices-of-vulnerability-following-brain-injury
#1
Andrea Mountney, Angela Boutte, Casandra M Cartagena, William J Flerlage, David Johnson, Chanyang Rho, Xi-Chun M Lu, Angela M Yarnell, Sean R Marcsisin, Jason Sousa, Chau Vuong, Victor E Zottig, Lai Yee Leung, Ying Deng-Bryant, Janice Gilsdorf, Frank C Tortella, Deborah A Shear
Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). Isolated concussions frequently produce acute neurological impairments; however, individuals typically recover spontaneously within a short time frame. In contrast, brain injuries resulting from multiple concussions can result in cumulative damage and elevated risk of developing chronic brain pathologies, including chronic traumatic encephalopathy (CTE). Increased attention has focused on identification of diagnostic markers that can prognostically serve as indices of brain health after injury, revealing the temporal profile of vulnerability to a second insult...
March 22, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28320452/compared-to-the-amniotic-membrane-wharton-s-jelly-may-be-a-more-suitable-source-of-mesenchymal-stem-cells-for-cardiovascular-tissue-engineering-and-clinical-regeneration
#2
Lei Pu, Mingyao Meng, Jian Wu, Jing Zhang, Zongliu Hou, Hui Gao, Hui Xu, Boyu Liu, Weiwei Tang, Lihong Jiang, Yaxiong Li
BACKGROUND: The success of developing cardiovascular tissue engineering (CTE) grafts greatly needs a readily available cell substitute for endothelial and interstitial cells. Perinatal annexes have been proposed as a valuable source of mesenchymal stem cells (MSCs) for tissue engineering and regenerative medicine. The objective of the present study is to evaluate the potential of human Wharton's jelly MSCs (WJ-MSCs) and amniotic membrane MSCs (AM-MSCs) as a seeding cell in CTE and cardiovascular regenerative medicine...
March 21, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28303453/altitudinal-patterns-and-controls-of-trace-metal-distribution-in-soils-of-a-remote-high-mountain-southwest-china
#3
Rui Li, Haijian Bing, Yanhong Wu, Jun Zhou, Zhongxiang Xiang
The aim of this study is to reveal the effects of regional human activity on trace metal accumulation in remote alpine ecosystems under long-distance atmospheric transport. Trace metals (Cd, Pb, and Zn) in soils of the Mt. Luoji, Southwest China, were investigated along a large altitudinal gradient [2200-3850 m above sea level (a.s.l.)] to elaborate the key factors controlling their distribution by Pb isotopic composition and statistical models. The concentrations of Cd, Pb, and Zn in the surface soils (O and A horizons) were relatively low at the altitudes of 3500-3700 m a...
March 16, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28286236/5-hydroxytyrosol-inhibits-hiv-1-replication-in-primary-cells-of-the-lower-and-upper-female-reproductive-tract
#4
Elisa Saba, Paola Panina-Bordignon, Isabel Pagani, Massimo Origoni, Massimo Candiani, Claudio Doglioni, Gianluca Taccagni, Silvia Ghezzi, José Alcami, Elisa Vicenzi, Guido Poli
We investigated the potential anti-HIV-1 activity of the candidate microbicide 5-hydroxytyrosol (5-HT) both in primary human cervical tissue explants (CTE), established from tissues of women undergoing histerectomy, and in endometrium-associated leukocytes (EAL). CTE were exposed to either the laboratory-adapted HIV-1BaL or to primary viral isolates in the presence or absence of 5-HT or 3TC/lamivudine as control and were then monitored for 12 days in terms of HIV-1 p24 Gag antigen production in culture supernatants...
March 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28269777/what-is-the-relationship-of-traumatic-brain-injury-to-dementia
#5
Mario F Mendez
There is a long history linking traumatic brain injury (TBI) with the development of dementia. Despite significant reservations, such as recall bias or concluding causality for TBI, a summary of recent research points to several conclusions on the TBI-dementia relationship. 1) Increasing severity of a single moderate-to-severe TBI increases the risk of subsequent Alzheimer's disease (AD), the most common type of dementia. 2) Repetitive, often subconcussive, mild TBIs increases the risk for chronic traumatic encephalopathy (CTE), a degenerative neuropathology...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28254594/the-current-status-of-research-on-chronic-traumatic-encephalopathy
#6
REVIEW
Kenneth Perrine, Jacqueline Helcer, Apostolos John Tsiouris, David J Pisapia, Philip Stieg
Chronic Traumatic Encephalopathy (CTE) evolved from the term "dementia pugilistica" describing the dementia found in many boxers to its current use in describing the dementia and depression sometimes found in athletes subjected to multiple concussions or sub-concussive blows to the head. Concurrently, the neuropathology evolved to specify a unique type of tauopathy found in perivascular spaces at the depth of sulci and other features not typically seen in neurodegenerative tauopathies. Four stages of CTE have been proposed, with four corresponding clinical syndromes of Traumatic Encephalopathy Syndrome...
February 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28240857/metal-organic-inorganic-nanocomposite-thermal-interface-materials-with-ultralow-thermal-resistances
#7
Cengiz Yegin, Nirup Nagabandi, Xuhui Feng, Charles King, Massimo Catalano, Jun Kyun Oh, Ansam J Talib, Ethan A Scholar, Stanislav V Verkhoturov, Tahir Cagin, Alexei V Sokolov, Moon J Kim, Kaiser Matin, Sreekant Narumanchi, Mustafa Akbulut
As electronic devices get smaller and more powerful, energy density of energy storage devices increases continuously, and moving components of machinery operate at higher speeds, the need for better thermal management strategies is becoming increasingly important. The removal of heat dissipated during the operation of electronic, electrochemical, and mechanical devices is facilitated by high-performance thermal interface materials (TIMs) which are utilized to couple devices to heat sinks. Herein, we report a new class of TIMs involving the chemical integration of boron nitride nanosheets (BNNS), soft organic linkers, and a copper matrix-which are prepared by the chemisorption-coupled electrodeposition approach...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229128/repetitive-head-impact-exposure-and-later-life-plasma-total-tau-in-former-national-football-league-players
#8
Michael L Alosco, Yorghos Tripodis, Johnny Jarnagin, Christine M Baugh, Brett Martin, Christine E Chaisson, Nate Estochen, Linan Song, Robert C Cantu, Andreas Jeromin, Robert A Stern
INTRODUCTION: Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau. METHODS: Ninety-six former NFL players (age 40-69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28224017/the-effect-of-carbamic-acid-1-2-3-thiadiazole-4-ylcarbonyl-hexyl-ester-on-peronophythora-litchii-infection-quality-and-physiology-of-postharvest-litchi-fruits
#9
Hai Liu, Guoxing Jing, Yueming Jiang, Fuying Luo, Zaifeng Li
BACKGROUND: Litchi (Litchi chinensis Sonn.) is a subtropical fruit with attractive characteristic of white to creamy semitranslucent flesh and red color in pericap, but it was easily subjected to the infection of Peronophythora litchii and lost its market values. Experiments were conducted to understand the effect of [Carbamic acid, (1,2,3-thiadiazole-4-ylcarbonyl)-hexyl ester, CTE] on the growth of P. litchi and quality properties in litchi fruits during postharvest storage. RESULTS: In vitro experiments, CTE with minimum inhibitory concentration (MIC, 5 mg/L) and minimum fungicidal concentration (MFC, 10 mg/L) were against the growth of P...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28223359/peptide-recognition-by-hp1-chromoshadow-domains-revisited-plasticity-in-the-pseudosymmetric-histone-binding-site-of-human-hp1
#10
Yanli Liu, Su Qin, Ming Lei, Wolfram Tempel, Yuzhe Zhang, Peter Loppnau, Yanjun Li, Jinrong Min
Heterochromatin protein 1 (HP1), a highly conserved non-histone chromosomal protein in eukaryotes, plays important roles in the regulation of gene transcription. Each of the three human homologs of HP1 includes a chromoshadow domain (CSD). The CSD interacts with various proteins bearing the PxVxL motif, but also with a region of histone H3 that bears the similar PxxVxL motif. The latter interaction has not yet been resolved in atomic detail. Here we demonstrate that the CSDs of all three human HP1 homologs have comparable affinities to the PxxVxL motif of histone H3...
February 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28214960/axonal-disruption-in-white-matter-underlying-cortical-sulcus-tau-pathology-in-chronic-traumatic-encephalopathy
#11
Laurena Holleran, Joong Hee Kim, Mihika Gangolli, Thor Stein, Victor Alvarez, Ann McKee, David L Brody
Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-mortem CTE studies have also reported myelin loss, axonal injury and white matter degeneration. Currently, the diagnosis of CTE is restricted to post-mortem neuropathological analysis. We hypothesized that high spatial resolution advanced diffusion MRI might be useful for detecting white matter microstructural changes directly adjacent to gray matter tau pathology...
March 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28205009/mixed-pathologies-including-chronic-traumatic-encephalopathy-account-for-dementia-in-retired-association-football-soccer-players
#12
Helen Ling, Huw R Morris, James W Neal, Andrew J Lees, John Hardy, Janice L Holton, Tamas Revesz, David D R Williams
In retired professional association football (soccer) players with a past history of repetitive head impacts, chronic traumatic encephalopathy (CTE) is a potential neurodegenerative cause of dementia and motor impairments. From 1980 to 2010, 14 retired footballers with dementia were followed up regularly until death. Their clinical data, playing career, and concussion history were prospectively collected. Next-of-kin provided consent for six to have post-mortem brain examination. Of the 14 male participants, 13 were professional and 1 was a committed amateur...
March 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28188060/mesenteric-findings-of-ct-enterography-are-well-correlated-with-the-endoscopic-severity-of-crohn-s-disease
#13
Takehiro Sakurai, Tatsuro Katsuno, Keiko Saito, Sayuri Yoshihama, Tomoo Nakagawa, Hirotaka Koseki, Takashi Taida, Hideaki Ishigami, Ken-Ichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Makoto Arai, Osamu Yokosuka
BACKGROUND: Maintenance of mucosal healing is a primary goal when treating Crohn's disease (CD). Endoscopy is the most precise method for the assessment of mucosal healing, but is considered overly invasive for patients with CD. In contrast, CT enterography (CTE) is less invasive, but little is known about the correlation between mucosal status and CTE parameters. METHODS: We recruited CD patients who underwent CTE and double balloon endoscopy (DBE) on the same day at our hospital between 2012 and 2014...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28186402/next-generation-electrochemical-energy-materials-for-intermediate-temperature-molten-oxide-fuel-cells-and-ion-transport-molten-oxide-membranes
#14
Valery V Belousov
High temperature electrochemical devices such as solid oxide fuel cells (SOFCs) and oxygen separators based on ceramic materials are used for efficient energy conversion. These devices generally operate in the temperature range of 800-1000 °C. The high operating temperatures lead to accelerated degradation of the SOFC and oxygen separator materials. To solve this problem, the operating temperatures of these electrochemical devices must be lowered. However, lowering the temperature is accompanied by decreasing the ionic conductivity of fuel cell electrolyte and oxygen separator membrane...
February 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28181891/-chronic-traumatic-encephalopathy-an-old-acquaintance-in-athletes
#15
E G B Vijverberg, A C M Pijnenburg, P Scheltens, Y A L Pijnenburg
- Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head injuries like those seen in sports such as boxing, American football and soccer.- The clinical features of CTE are a range of cognitive, psychiatric and motor symptoms, and histopathology involves deposits of hyperphosphorylated tau protein and the presence of TAR DNA-binding protein (TDP-43) with relatively little beta-amyloid.- CTE is difficult to differentiate clinically from Alzheimer's disease, frontotemporal dementia and psychiatric disorders because of the major symptom overlap between these conditions...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28178914/a-survey-of-senior-medical-students-attitudes-and-awareness-toward-teaching-and-participation-in-a-formal-clinical-teaching-elective-a-canadian-perspective
#16
J D Matthew Hughes, Elise Azzi, Gregory Walter Rose, Christopher J Ramnanan, Karima Khamisa
BACKGROUND: To prepare for careers in medicine, medical trainees must develop clinical teaching skills. It is unclear if Canadian medical students need or want to develop such skills. We sought to assess Canadian students' perceptions of clinical teaching, and their desire to pursue clinical teaching skills development via a clinical teaching elective (CTE) in their final year of medical school. METHODS: We designed a descriptive cross-sectional study of Canadian senior medical students, using an online survey to gauge teaching experience, career goals, perceived areas of confidence, and interest in a CTE...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28154186/structural-analysis-reveals-the-deleterious-effects-of-telomerase-mutations-in-telomerase-associated-bone-marrow-failure-syndromes
#17
Hunter Hoffman, Cory Rice, Emmanuel Skordalakes
Naturally occurring mutations in the ribonucleoprotein reverse transcriptase, telomerase, are associated with the bone marrow failure syndromes dyskeratosis congenita (DKC), aplastic anemia (AA), and idiopathic pulmonary fibrosis (IPF). However, the mechanism by which these mutations impact telomerase function remains unknown. Here we present the structure of the human telomerase c-terminal extension (CTE or thumb domain) determined by the method of single-wavelength anomalous diffraction (SAD) to 2.31 A resolution...
February 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28144162/thoracic-epidural-catheter-for-postoperative-pain-control-following-an-ineffective-transversus-abdominis-plane-block-using-liposome-bupivacaine
#18
Brian D Terrien, David Espinoza, Charles C Stehman, Gabriel A Rodriguez, Nicholas C Connolly
A 24-year-old female with a history of ulcerative colitis underwent colectomy. The patient received an ineffective transversus abdominis plane (TAP) block with liposome bupivacaine (Exparel) intraoperatively and was started on a hydromorphone patient-controlled analgesia 5 hours after the TAP block, which did not relieve her pain. A continuous thoracic epidural (CTE) was then placed after blood levels of bupivacaine were drawn, and the patient immediately experienced significant pain relief. The combined use of liposome bupivacaine and bupivacaine CTE infusion in the postoperative management of this patient demonstrated no safety concerns, provided excellent analgesia and plasma concentrations of bupivacaine remained far below toxic levels...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28106517/traditional-invasive-and-synchrotron-based-noninvasive-assessments-of-three-dimensional-printed-hybrid-cartilage-constructs-in-situ
#19
Adeola D Olubamiji, Ning Zhu, Tuanjie Chang, Chijioke K Nwankwo, Zohreh Izadifar, Ali Honaramooz, Xiongbiao Chen, B Frank Eames
Three-dimensional (3D)-printed constructs made of polycaprolactone and chondrocyte-impregnated alginate hydrogel (hybrid cartilage constructs) can mimic the biphasic nature of articular cartilage, thus offering promise for cartilage tissue engineering applications. Notably, the regulatory pathway for medical device development requires validation of such constructs through in vitro bench tests and in vivo preclinical examinations for premarket approval. For this, noninvasive imaging techniques are required for effective evaluation of the progress of these cartilage constructs, especially when implanted in animal models or human subjects...
March 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28096971/carthamus-tinctorius-l-ameliorates-brain-injury-followed-by-cerebral-ischemia-reperfusion-in-rats-by-antioxidative-and-anti-inflammatory-mechanisms
#20
Pin-Kuei Fu, Tai-Long Pan, Chi-Yu Yang, Kee-Ching Jeng, Nou-Ying Tang, Ching-Liang Hsieh
OBJECTIVES: Carthamus tinctorius L. (CT) or safflower is widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia-reperfusion (I/R) brain injury and elucidated the underlying mechanism. MATERIALS AND METHODS: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period...
December 2016: Iranian Journal of Basic Medical Sciences
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