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https://www.readbyqxmd.com/read/28990474/telomerase-reverse-transcriptase-gene-from-greasyback-shrimp-metapenaeus-ensis-isolation-genomic-organization-and-expression-pattern-analysis
#1
Cuicui Liang, Yuhao Wang, Yujie Wang, Xuemei Chen, Huarong Guo
Telomerase reverse transcriptase (TERT), a catalytic subunit of telomerase, plays a key role in the activity and biological functions of telomerase. In the present study we isolated and characterized the full-length cDNA and DNA sequences of the TERT gene (MeTERT) from Metapenaeus ensis. MeTERT cDNA was 4239 bp in length, which consisted of a 369 bp 5'UTR, a 3231 bp open reading frame encoding 1076 amino acids, and a 639 bp 3'UTR. The genomic DNA of MeTERT had only two introns, similar to beetle (two introns) and silkworm (intronless)...
October 2017: Zoological Science
https://www.readbyqxmd.com/read/28990457/age-at-first-exposure-to-repetitive-head-impacts-is-associated-with-smaller-thalamic-volumes-in-former-professional-american-football-players
#2
Vivian Schultz, Robert A Stern, Yorghos Tripodis, Julie M Stamm, Pawel Wrobel, Christian Lepage, Isabelle Weir, Jeffrey P Guenette, Alicia Chua, Michael L Alosco, Christine M Baugh, Nathan G Fritts, Brett Martin, Christine Chaisson, Michael J Coleman, Alexander P Lin, Ofer Pasternak, Martha E Shenton, Inga Katharina Koerte
Thalamic atrophy has been associated with exposure to repetitive head impacts (RHI) in professional fighters. The aim of this study is to investigate whether or not age at first exposure (AFE) to RHI is associated with thalamic volume in symptomatic former National Football League (NFL) players at risk for chronic traumatic encephalopathy (CTE). Eighty-six symptomatic former NFL players (mean age=54.9±7.9 years) were included. T1-weighted data were acquired on a 3T MRI and thalamic volumes were derived using FreeSurfer...
October 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28987182/tauopathies
#3
Gabor G Kovacs
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include globular glial tauopathies, primary age-related tauopathy, which includes neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), and aging-related tau astrogliopathy...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28975240/research-gaps-and-controversies-in-chronic-traumatic-encephalopathy-a-review
#4
Breton M Asken, Molly J Sullan, Steven T DeKosky, Michael S Jaffee, Russell M Bauer
Importance: Scientific and lay interest in negative outcomes associated with exposure to repetitive brain trauma (RBT) continues to strengthen. Concerns about the association between RBT and dementia began more than a century ago, but have resurfaced in the last decade with the more recently described chronic traumatic encephalopathy (CTE). Chronic traumatic encephalopathy is a tauopathy associated with RBT that has become inextricably linked to conversations about sport-related concussion and mild traumatic brain injury...
October 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28972790/evaluation-of-bowel-distension-and-bowel-wall-visualization-according-to-patient-positions-during-administration-of-oral-contrast-media-for-ct-enterography
#5
Seul Bi Lee, Seung Ho Kim, Jung Hee Son, Ji Yeon Baik
OBJECTIVE: To compare small bowel distension and bowel wall visualization among three different patients' positions (supine, sitting and right decubitus) during administration of oral contrast media in preparation for CT enterography. METHODS: A total of 150 consecutive patients (104 men and 46 women; mean age 34.6 years, range 15-78 years) who were scheduled to undergo CTE were recruited. Patients were randomly allocated into the three position groups during oral contrast media administration, and there were 50 patients in each group...
October 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28950005/ccl11-is-increased-in-the-cns-in-chronic-traumatic-encephalopathy-but-not-in-alzheimer-s-disease
#6
Jonathan D Cherry, Thor D Stein, Yorghos Tripodis, Victor E Alvarez, Bertrand R Huber, Rhoda Au, Patrick T Kiernan, Daniel H Daneshvar, Jesse Mez, Todd M Solomon, Michael L Alosco, Ann C McKee
CCL11, a protein previously associated with age-associated cognitive decline, is observed to be increased in the brain and cerebrospinal fluid (CSF) in chronic traumatic encephalopathy (CTE) compared to Alzheimer's disease (AD). Using a cohort of 23 deceased American football players with neuropathologically verified CTE, 50 subjects with neuropathologically diagnosed AD, and 18 non-athlete controls, CCL11 was measured with ELISA in the dorsolateral frontal cortex (DLFC) and CSF. CCL11 levels were significantly increased in the DLFC in subjects with CTE (fold change = 1...
2017: PloS One
https://www.readbyqxmd.com/read/28937955/military-blast-injury-and-chronic-neurodegeneration-research-presentations-from-the-2015-international-state-of-the-science-meeting
#7
Denes Agoston, Peethambaran Arun, Patrick Bellgowan, Steven Broglio, Robert Cantu, David Cook, Uade Olaghere da Silva, Dara Dickstein, Gregory Elder, Elizabeth Fudge, Sam Gandy, Jessica Gill, John F Glenn, Raj K Gupta, Sidney Hinds, Stuart Hoffman, Theresa Lattimore, Alexander Lin, Kun Ping Lu, Joseph Maroon, David Okonkwo, Daniel Perl, Meghan Robinson, Charles Rosen, Douglas Smith
Blast-related traumatic brain injury (TBI) is a signature injury of recent military conflicts, leading to increased Department of Defense (DoD) interest in its potential long-term effects, such as chronic traumatic encephalopathy (CTE). The DoD Blast Injury Research Program Coordinating Office convened the 2015 International State-of-the-Science Meeting to discuss the existing evidence regarding a causal relationship between TBI and CTE. Over the course of the meeting, experts across government, academia, and the sports community presented cutting edge research on the unique pathological characteristics of blast-related TBI, blast-related neurodegenerative mechanisms, risk factors for CTE, potential biomarkers for CTE, and treatment strategies for chronic neurodegeneration...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28937953/the-biological-basis-of-chronic-traumatic-encephalopathy-following-blast-injury-a-literature-review
#8
Matt Aldag, Regina C Armstrong, Faris Bandak, Patrick S F Bellgowan, Timothy Bentley, Sean Biggerstaff, Katrina Caravelli, Joan Cmarik, Alicia Crowder, Thomas J DeGraba, Travis A Dittmer, Richard G Ellenbogen, Colin Greene, Raj K Gupta, Ramona Hicks, Stuart Hoffman, Robert C Latta, Michael J Leggieri, Donald Marion, Robert Mazzoli, Michael McCrea, John O'Donnell, Mark Packer, James B Petro, Todd E Rasmussen, Wendy Sammons-Jackson, Richard Shoge, Victoria Tepe, Ladd A Tremaine, James Zheng
The United States Department of Defense Blast Injury Research Program Coordinating Office organized the 2015 International State-of-the-Science meeting to explore links between blast-related head injury and the development of chronic traumatic encephalopathy (CTE). Before the meeting, the planning committee examined articles published between 2005 and October 2015 and prepared this literature review, which summarized broadly CTE research and addressed questions about the pathophysiological basis of CTE and its relationship to blast- and nonblast-related head injury...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28937952/modeling-the-long-term-consequences-of-repeated-blast-induced-mild-traumatic-brain-injuries
#9
Denes V Agoston
Repeated mild traumatic brain injury (rmTBI) caused by playing collision sports or by exposure to blasts during military operations can lead to late onset, chronic diseases such as chronic traumatic encephalopathy (CTE), a progressive neurodegenerative condition that manifests in increasingly severe neuropsychiatric abnormalities years after the last injury. Currently, because of the heterogeneity of the clinical presentation, confirmation of a CTE diagnosis requires post-mortem examination of the brain. The hallmarks of CTE are abnormal accumulation of phosphorylated tau protein, TDP-43 immunoreactive neuronal cytoplasmic inclusions, and astroglial abnormalities, but the pathomechanism leading to these terminal findings remains unknown...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28924733/erratum-to-editorial-do-orthopaedic-surgeons-belong-on-the-sidelines-at-american-football-games
#10
Seth S Leopold, Matthew B Dobbs, Mark C Gebhardt, Terence J Gioe, Clare M Rimnac, Montri D Wongworawat
In the November Editorial, "Editorial: Do Orthopaedic Surgeons Belong on the Sidelines at American Football Games?" a statistic was attributed to a JAMA study (Ref. 10) that should have been attributed to an article from the New York Times (Ref. 16). The sentence in question should read: "We accept that critique, provided that the skeptics acknowledge that the best-case estimate in support of the safety of football would result in a CTE prevalence estimate of 9%, since only another 1200 ex-NFL players have died [16] since this research group [10] began studying football players' brains...
September 18, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28888534/psychiatric-phenotypes-in-chronic-traumatic-encephalopathy
#11
REVIEW
Ian Mahar, Michael L Alosco, Ann C McKee
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder involving cognitive, motor, and psychiatrically-relevant symptoms resulting from repetitive head impacts. Psychiatric phenotypes of CTE, including depression and suicidality, present particular challenges for CTE research, given that the diagnosis requires postmortem neuropathological examination. The pathognomonic lesion of CTE is the perivascular accumulation of hyperphosphorylated tau (ptau) protein at the depths of cortical sulci. These lesions are found in the earliest disease stages, and with advancing pathological severity, ptau deposition occurs in widespread brain regions in a four-stage scheme of severity...
September 6, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28883529/the-formation-of-nanocrystalline-zro2-nuclei-in-a-li2o-al2o3-sio2-glass-a-combined-xanes-and-tem-study
#12
Enrico Kleebusch, Christian Patzig, Michael Krause, Yongfeng Hu, Thomas Höche, Christian Rüssel
The high economic importance of glass ceramics based on Li2O/Al2O3/SiO2 (LAS) is mainly due to their low coefficients of thermal expansion (CTE), which make these materials suitable candidates for a number of applications. The exact mechanism of the crystallization processes in LAS glasses is still not fully understood. The present work focuses on the formation and development of nanocrystalline ZrO2 within an LAS base composition which contains only ZrO2 as nucleating agent. Using a combination of transmission electron microscopy and X-ray absorption spectroscopy techniques, the temporal evolution of the ZrO2 nanocrystal formation is described...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870119/a-history-of-concussions-is-associated-with-symptoms-of-common-mental-disorders-in-former-male-professional-athletes-across-a-range-of-sports
#13
Vincent Gouttebarge, Haruhito Aoki, Michael Lambert, William Stewart, Gino Kerkhoffs
OBJECTIVE: Recent reports suggest that exposure to repetitive concussions in sports is associated with an increased risk of symptoms of distress, anxiety and depression, sleep disturbance or substance abuse/dependence (typically referred as symptoms of common mental disorders[CMD]) and of later development of neurodegenerative disease, in particular chronic traumatic encephalopathy (CTE). The primary aim of this study was to explore the relationship between sports career-related concussions and the subsequent occurrence of symptoms of CMD among former male professional athletes retired from football (soccer), ice hockey and rugby (union)...
September 5, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28867009/sex-differences-in-the-effect-of-diabetes-mellitus-on-platelet-reactivity-and-coronary-thrombosis-from-the-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-adapt-des-study
#14
Gennaro Giustino, Björn Redfors, Roxana Mehran, Ajay J Kirtane, Usman Baber, Philippe Généreux, Bernhard Witzenbichler, Franz-Josef Neumann, Giora Weisz, Akiko Maehara, Michael J Rinaldi, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Bruce R Brodie, Thomas D Stuckey, George D Dangas, Sorin J Brener, M Ozgu Ozan, Gregg W Stone
BACKGROUND: Whether the consequences of diabetes mellitus (DM) are worse for women than for men treated with drug-eluting stents (DES) and antiplatelet therapy remain unclear. METHODS: Patients from the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents study were stratified according to sex and DM status. We investigated the sex-specific effect of DM on high on-clopidogrel platelet reactivity (HPR), defined as a P2Y12 reaction units ≥208, and the adjusted association of DM on the 2-year risk for coronary thrombotic events (CTE), defined as spontaneous myocardial infarction or definite or probable stent thrombosis...
November 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28859995/glymphatic-system-disruption-as-a-mediator-of-brain-trauma-and-chronic-traumatic-encephalopathy
#15
REVIEW
Molly J Sullan, Breton M Asken, Michael S Jaffee, Steven T DeKosky, Russell M Bauer
Traumatic brain injury (TBI) is an increasingly important issue among veterans, athletes and the general public. Difficulties with sleep onset and maintenance are among the most commonly reported symptoms following injury, and sleep debt is associated with increased accumulation of beta amyloid (Aβ) and phosphorylated tau (p-tau) in the interstitial space. Recent research into the glymphatic system, a lymphatic-like metabolic clearance mechanism in the central nervous system (CNS) which relies on cerebrospinal fluid (CSF), interstitial fluid (ISF), and astrocytic processes, shows that clearance is potentiated during sleep...
August 30, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28852526/identification-of-the-distinguishing-features-of-crohn-s-disease-and-ischemic-colitis-using-computed-tomographic-enterography
#16
Min Chen, Erick M Remer, Xiuli Liu, Rocio Lopez, Bo Shen
Background and aims: The differential diagnosis between Crohn's disease (CD) and ischemic colitis (ISC) is important as their clinical management is different. ISC can easily be misdiagnosed as CD, especially in elderly populations. The distinctive radiographic features of the two disease entities have not been investigated. The aim of this study is to assess the utility of computed tomographic enterography (CTE) in the differential diagnosis between CD and ISC. Methods: Patients with confirmed CD and ISC were identified through an electronic medical record search of the Cleveland Clinic Foundation...
August 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28851546/chronic-traumatic-encephalopathy-integration-of-canonical-traumatic-brain-injury-secondary-injury-mechanisms-with-tau-pathology
#17
REVIEW
Jacqueline R Kulbe, Edward D Hall
In recent years, a new neurodegenerative tauopathy labeled Chronic Traumatic Encephalopathy (CTE), has been identified that is believed to be primarily a sequela of repeated mild traumatic brain injury (TBI), often referred to as concussion, that occurs in athletes participating in contact sports (e.g. boxing, American football, Australian football, rugby, soccer, ice hockey) or in military combatants, especially after blast-induced injuries. Since the identification of CTE, and its neuropathological finding of deposits of hyperphosphorylated tau protein, mechanistic attention has been on lumping the disorder together with various other non-traumatic neurodegenerative tauopathies...
August 26, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28835772/faecal-biomarkers-for-screening-small-bowel-inflammation-in-patients-with-crohn-s-disease-a-prospective-study
#18
Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae, Koichi Matsumoto
BACKGROUND: The value of faecal biomarkers for screening small bowel inflammation in patients with Crohn's disease (CD) remains to be elucidated. This prospective study was to evaluate the utility of faecal biomarkers for detecting small intestinal inflammation. METHODS: A total of 122 consecutive patients with a diagnosis of CD in the small intestine were screened for eligibility. Computed tomography enterography (CTE) was undertaken to evaluate small bowel inflammation followed by colonoscopy to confirm no large bowel involvement...
August 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28832034/surface-modified-polymers-for-cardiac-tissue-engineering
#19
REVIEW
Ambigapathi Moorthi, Yu-Chang Tyan, Tze-Wen Chung
Cardiovascular disease (CVD), leading to myocardial infarction and heart failure, is one of the major causes of death worldwide. The physiological system cannot significantly regenerate the capabilities of a damaged heart. The current treatment involves pharmacological and surgical interventions; however, less invasive and more cost-effective approaches are sought. Such new approaches are developed to induce tissue regeneration following injury. Hence, regenerative medicine plays a key role in treating CVD...
September 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28831126/increasing-the-doping-efficiency-by-surface-energy-control-for-ultra-transparent-graphene-conductors
#20
Kai-Wen Chang, Ya-Ping Hsieh, Chu-Chi Ting, Yen-Hsun Su, Mario Hofmann
Graphene's attractiveness in many applications is limited by its high resistance. Extrinsic doping has shown promise to overcome this challenge but graphene's performance remains below industry requirements. This issue is caused by a limited charge transfer efficiency (CTE) between dopant and graphene. Using AuCl3 as a model system, we measure CTE as low as 5% of the expected values due to the geometrical capacitance of small adsorbate clusters. We here demonstrate a strategy for enhancing the CTE by a two-step optimization of graphene's surface energy prior to AuCl3 doping...
August 22, 2017: Scientific Reports
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