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https://www.readbyqxmd.com/read/29216694/-evidence-level-and-grade-of-recommendation-of-the-ponseti-method-for-arthrogryposis-related-syndromic-talipes-equinovarus-and-moebius-syndrome-a-systematic-review
#1
J J Guerra-Jasso, J A Valcarce-León, H M Quíntela-Núñez-Del Prado
BACKGROUND: Adduct congenital talipes equinovarus (CTE) or clubfoot is a common musculoskeletal malformation affecting between 1 and 4.5 out of every 1000 live births. It is usually associated with arthrogryposis and Moebius syndrome with the latter two being more difficult to treat as they require aggressive surgery to achieve a plantigrade foot. We therefore ask what is the evidence level and grade of recommendation of the Ponseti method to treat syndromic talipes equinovarus resulting from arthrogryposis and Moebius syndrome...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29213517/soccer-football-association-and-chronic-traumatic-encephalopathy-a-short-review-and-recommendation
#2
REVIEW
Ricardo Nitrini
Chronic traumatic encephalopathy (CTE) was initially described in boxers, but in recent years it has been reported in other settings, particularly in contact sports and military personnel. Soccer (football association) had previously been (and still is) considered relatively safe when compared to other sports, such as American football. However, a few cases of professional soccer players with CTE have been reported in the last few years. It is still unknown how frequent this condition is in soccer players, and the role played by heading the ball remains elusive...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29212708/the-crystal-structure-of-pseudokinase-peak1-sugen-kinase-269-reveals-an-unusual-catalytic-cleft-and-a-novel-mode-of-kinase-fold-dimerization
#3
Byung Hak Ha, Titus J Boggon
The pseudokinase group encompasses some 10% of protein kinases, but pseudokinases diverge from canonical kinases in key motifs. The two members of the small new kinase family 3 (NKF3) group are considered pseudokinases. These proteins, pseudopodium-enriched atypical kinase 1 (PEAK1, Sugen Kinase 269, or SgK269) and pragmin (Sugen Kinase 223 or SgK223) act as scaffolds in growth factor signaling pathways, and both contain a kinase fold with degraded kinase motifs at their C termini. These kinases may harbor regions that mediate oligomerization or control other aspects of signal transduction, but a lack of structural information has precluded detailed investigations into their functional roles...
December 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29188242/highly-transparent-and-rollable-pva-co-pe-nanofibers-synergistically-reinforced-with-epoxy-film-for-flexible-electronic-devices
#4
Bing Xiong, Weibing Zhong, Qing Zhu, Ke Liu, Mufang Li, Gang Sun, Dong Wang
The development of electronics towards a more functions-integrated, flexible and stretchable direction requires mechanically flexible substrates with high thermal and dimensional stability and optical transparency. Herein, rolls of an optically transparent PVA-co-PE nanofibrous membrane/epoxy composite with synergistically enhanced thermal stability, very low CTE, and outstanding mechanical properties are reported. The nanoscale size, the unique inter-stack structure, and the strong interfacial interactions between the PVA-co-PE nanofibers and the epoxy contribute to the synergistic effects...
November 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/29168373/kocuria-kristinae-caused-sepsis-in-an-infant-with-congenital-tufting-enteropathy
#5
Malik Aydin, Rainer Ganschow, Martin Jankofsky
Aydin M, Ganschow R, Jankofsky M. Kocuria kristinae-caused sepsis in an infant with congenital tufting enteropathy. Turk J Pediatr 2017; 59: 93-96. Congenital tufting enteropathy (CTE) is characterized by the early-onset of chronic diarrhea and the inability to develop. It is a rare congenital disease with a low prevalence of 1:50,000 - 100,000 live births p.a. The histopathology is characterized by villous atrophy and the characteristic epithelial tufts. Recent identification of causative mutations in EpCAM has enhanced our understanding of this disease...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29167734/treatment-of-chronic-telogen-effluvium-with-oral-minoxidil-a-retrospective-study
#6
Eshini Perera, Rodney Sinclair
Background: Chronic telogen effluvium (CTE) may be primary or secondary to various causes, including drug reaction, nutritional deficiency and female pattern hair loss (FPHL).  Oral minoxidil stimulates hair growth, and topical minoxidil is used in the treatment of FPHL and male androgenetic alopecia. minoxidil has not been used to treat CTE. This study aimed to assess the treatment of CTE with once daily oral minoxidil. Methods: Women with a diagnosis of CTE based on >6 month history of increased telogen hair shedding, no visible mid frontal scalp hair loss (Sinclair stage 1) and no hair follicle miniaturization on scalp biopsy were treated with once daily oral minoxidil...
2017: F1000Research
https://www.readbyqxmd.com/read/29145658/characterization-of-detergent-insoluble-proteome-in-chronic-traumatic-encephalopathy
#7
Jonathan D Cherry, Ahmad Zeineddin, Eric B Dammer, James A Webster, Duc Duong, Nicholas T Seyfried, Allan I Levey, Victor E Alvarez, Bertrand R Huber, Thor D Stein, Patrick T Kiernan, Ann C McKee, James J Lah, Chadwick M Hales
Quantitative proteomics of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer disease (AD) and frontotemporal dementia. Similar studies in chronic traumatic encephalopathy (CTE) are limited, therefore we hypothesized that proteomic sequencing of CTE frontal cortex brain homogenates from varying CTE pathologic stages may provide important new insights into this disorder. Quantitative proteomics of control, CTE and AD brains was performed to characterize differentially expressed proteins, and we identified over 4000 proteins in CTE brains, including significant enrichment of the microtubule associated protein tau...
November 14, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29139059/evolution-of-rubisco-activase-gene-in-plants
#8
Ragupathi Nagarajan, Kulvinder S Gill
Rubisco activase of plants evolved in a stepwise manner without losing its function to adapt to the major evolutionary events including endosymbiosis and land colonization. Rubisco activase is an essential enzyme for photosynthesis, which removes inhibitory sugar phosphates from the active sites of Rubisco, a process necessary for Rubisco activation and carbon fixation. The gene probably evolved in cyanobacteria as different species differ for its presence. However, the gene is present in all other plant species...
November 14, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29136240/postmortem-autopsy-confirmation-of-antemortem-f-18-fddnp-pet-scans-in-a-football-player-with-chronic-traumatic-encephalopathy
#9
Bennet Omalu, Gary W Small, Julian Bailes, Linda M Ercoli, David A Merrill, Koon-Pong Wong, Sung-Cheng Huang, Nagichettiar Satyamurthy, Jennifer L Hammers, John Lee, Robert P Fitzsimmons, Jorge R Barrio
Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest...
November 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29108873/the-comparison-of-the-effectiveness-of-conventional-therapeutic-exercises-and-pilates-on-pain-and-function-in-patients-with-knee-osteoarthritis
#10
Vahid Mazloum, Pouya Rabiei, Nader Rahnama, Elnaz Sabzehparvar
The aim of this study was to investigate the effectiveness of two different interventions on pain and disability in patients with knee osteoarthritis (KOA). Forty-one individuals (Mean ± SD: Age 52.1 ± 8.9 years, Height 172.8 ± 6.6 cm, Weight 80.2 ± 6.9 kg) with KOA were randomly allocated into Pilates (N = 14), conventional therapeutic exercise (CTE) (N = 14), and control (N = 13) groups. Joint position sense (JPS), functional performance, pain, and disability were examined using Biodex system, aggregate time of four daily activities, and Lequesne Index...
October 22, 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29106420/a-small-graphene-oxide-sheet-polyvinylidene-fluoride-bilayer-actuator-with-large-and-rapid-responses-to-multiple-stimuli
#11
Guochuang Xu, Miao Zhang, Qinqin Zhou, Hongwu Chen, Tiantian Gao, Chun Li, Gaoquan Shi
A high-performance actuator should be able to deliver large-shape deformations, fast actuations and sensitive responses to multiple stimuli. Here, we report such an actuator constructed from one layer of polyvinylidene fluoride (PVDF) with a high coefficient of thermal expansion (CTE), and another layer of small sheets of graphene oxide (SGO) with a negative CTE. The opposite deformations of both actuation layers make the SGO/PVDF bilayer actuator highly sensitive to the temperature stimulus with a large bending sensitivity of 1...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29103039/the-need-to-separate-chronic-traumatic-encephalopathy-neuropathology-from-clinical-features
#12
Grant L Iverson, C Dirk Keene, George Perry, Rudolph J Castellani
There is tremendous recent interest in chronic traumatic encephalopathy (CTE) in former collision sport athletes, civilians, and military veterans. This critical review places important recent research results into a historical context. In 2015, preliminary consensus criteria were developed for defining the neuropathology of CTE, which substantially narrowed the pathology previously reported to be characteristic. There are no agreed upon clinical criteria for diagnosis, although sets of criteria have been proposed for research purposes...
October 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29089823/ct-enterography-for-surveillance-of-anastomotic-recurrence-within-12-months-of-bowel-resection-in-patients-with-crohn-s-disease-an-observational-study-using-an-8-year-registry
#13
In Young Choi, Sang Hyoung Park, Seong Ho Park, Chang Sik Yu, Yong Sik Yoon, Jong Lyul Lee, Byong Duk Ye, Ah Young Kim, Suk-Kyun Yang
OBJECTIVE: To investigate the diagnostic yield and accuracy of CT enterography (CTE) for early (< 12 postoperative months) surveillance of anastomotic recurrence after bowel resection for Crohn's disease (CD). MATERIALS AND METHODS: We analyzed 88 adults (60 males and 28 females; mean age, 31.4 ± 9.6 years) who underwent bowel surgery for CD that created ileocolic anastomosis without enteric stoma, and underwent CTE for surveillance of CD recurrence/aggravation within 12 post-operative months...
November 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29089538/determination-on-the-coefficient-of-thermal-expansion-in-high-power-ingan-based-light-emitting-diodes-by-optical-coherence-tomography
#14
Ya-Ju Lee, Chun-Yang Chou, Chun-Ying Huang, Yung-Chi Yao, Yi-Kai Haung, Meng-Tsan Tsai
The coefficient of thermal expansion (CTE) is a physical quantity that indicates the thermal expansion value of a material upon heating. For advanced thermal management, the accurate and immediate determination of the CTE of packaging materials is gaining importance because the demand for high-power lighting-emitting diodes (LEDs) is currently increasing. In this study, we used optical coherence tomography (OCT) to measure the CTE of an InGaN-based (λ = 450 nm) high-power LED encapsulated in polystyrene resin...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29081651/comparison-of-patients-tolerance-between-computed-tomography-enterography-and-double-balloon-enteroscopy
#15
Maochen Zhang, Tianyu Zhang, Liwen Hong, Qiangqiang Wu, Yun Lin, Mengfan Xie, Rong Fan, Zhengting Wang, Jie Zhou, Jie Zhong
BACKGROUND: Computed tomography enterography (CTE) and double-balloon enteroscopy (DBE) are widely used in diagnosis of small bowel diseases. Both of these examinations bring discomfort to patients. The aim of this study was to compare patients' tolerance and preference between CTE and DBE. METHODS: From August 1, 2014 to December 31, 2016, patients with suspected or known small bowel diseases who underwent both CTE and DBE were prospectively enrolled in our study...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29077582/neuroimaging-in-the-diagnosis-of-chronic-traumatic-encephalopathy-a-systematic-review
#16
Philip Sparks, Tim Lawrence, Stephan Hinze
OBJECTIVE: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repeated subconcussive and concussive head injury. Clinical features include cognitive, behavioral, mood, and motor impairments. Definitive diagnosis is only possible at postmortem. Here, the utility of neuroimaging in the diagnosis of CTE is evaluated by systematically reviewing recent evidence for changes in neuroimaging biomarkers in suspected cases of CTE compared with controls. DATA SOURCES: Providing an update on a previous systematic review of articles published until December 2014, we searched for articles published between December 2014 and July 2016...
October 25, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29059545/the-effect-of-without-using-anisodamine-during-ct-enterography-on-image-quality-diagnostic-performance-and-latent-side-effects
#17
Didi Wen, Jian Xu, Ying Liu, Rui An, Jian Li, Hongliang Zhao, Minwen Zheng
OBJECTIVE: To examine whether no anisodamine injection before CTE was feasible without impairing image quality and diagnostic performance. MATERIALS: The change of mural thickness and luminal diameter were compared between using and no using anisodamine. The diagnostic performance of small-bowel disease was analyzed and compared. RESULTS: No motion artifact was detected in two groups. There was no significant difference regarding the change of luminal diameter and mural thickness (all P>0...
October 17, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29051643/synthesis-characteristics-and-evaluation-of-antioxidant-activity-of-1-tannin-ether-ethyl-stearate
#18
Kang Zhang, Xiaohua Zhang, Yan Li, Xinxin Wang, Qing Cao, Li'e Jin
The [1-(tannin-ether)-ethyl]stearate (TEES) was synthesized by two-stage process successfully. 1-Chloroethyl tannin ether (CTE), as an intermediate, was initially prepared with tannic acid (TA) and paraldehyde. Then, the TEES was synthesized by sodium stearate and CTE in the presence of FeCl3-PEG-400 as phase-transfer catalyst. Synthetic conditions were optimized. The structural characteristics of TEES were analyzed by FTIR, (1)H NMR and UV-vis techniques. And the thermal stability of TEES was investigated...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29042562/cis-p-tau-is-induced-in-clinical-and-preclinical-brain-injury-and-contributes-to-post-injury-sequelae
#19
Onder Albayram, Asami Kondo, Rebekah Mannix, Colin Smith, Cheng-Yu Tsai, Chenyu Li, Megan K Herbert, Jianhua Qiu, Michael Monuteaux, Jane Driver, Sandra Yan, William Gormley, Ava M Puccio, David O Okonkwo, Brandon Lucke-Wold, Julian Bailes, William Meehan, Mark Zeidel, Kun Ping Lu, Xiao Zhen Zhou
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease. We previously showed that cis phosphorylated tau (cis P-tau), but not the trans form, contributes to tau pathology and functional impairment in an animal model of severe TBI. Here we found that in human samples obtained post TBI due to a variety of causes, cis P-tau is induced in cortical axons and cerebrospinal fluid and positively correlates with axonal injury and clinical outcome...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29038856/comparison-of-diagnostic-performance-between-1-millisievert-ct-enterography-and-half-standard-dose-ct-enterography-for-evaluating-active-inflammation-in-patients-with-crohn-s-disease
#20
Jung Hee Son, Seung Ho Kim, Een Young Cho, Kyeong Hwa Ryu
PURPOSE: To compare the diagnostic performance of CT enterography (CTE) images obtained at 1 millisievert (mSv) and reconstructed with filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASIR) with those of half-dose CTE images for the evaluation of active inflammation in patients with Crohn's disease. METHODS: Forty-six consecutive patients (mean age 29 years; range 15-59 years) with Crohn's disease underwent CTE which comprised a standard-dose scan at the enteric phase (45 s), a half-dose scan with ASIR at the portal venous phase (70 s), and 1 mSv scans with FBP and ASIR at the delayed phase (90 s) under a fixed 120 kVp and variable mAs...
October 16, 2017: Abdominal Radiology
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