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https://www.readbyqxmd.com/read/27918046/a-ruthenium-tellurocarbonyl-cte-complex-with-a-cyclopentadienyl-ligand-systematic-studies-of-a-series-of-chalcogenocarbonyl-complexes-cprucl-ce-h2imes-e-o-s-se-te
#1
Ayumi Suzuki, Takahiro Arai, Kota Ikenaga, Yuichiro Mutoh, Noriko Tsuchida, Shinichi Saito, Youichi Ishii
The first tellurocarbonyl complex with a half-sandwich structure [CpRuCl(CTe)(H2IMes)] was synthesized by a ligand substitution reaction. The practically complete series of the CpCE complexes [CpRuCl(CE)(H2IMes)] (E = O, S, Se, Te) were systematically explored. The tellurium atom in the CTe complex could be smoothly replaced with lighter chalcogen atoms.
December 5, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27916951/silica-based-and-borate-based-titania-containing-bioactive-coatings-characterization-critical-strain-energy-release-rate-residual-stresses-hardness-and-thermal-expansion
#2
Omar Rodriguez, Ali Matinmanesh, Sunjeev Phull, Emil H Schemitsch, Paul Zalzal, Owen M Clarkin, Marcello Papini, Mark R Towler
Silica-based and borate-based glass series, with increasing amounts of TiO₂ incorporated, are characterized in terms of their mechanical properties relevant to their use as metallic coating materials. It is observed that borate-based glasses exhibit CTE (Coefficient of Thermal Expansion) closer to the substrate's (Ti6Al4V) CTE, translating into higher mode I critical strain energy release rates of glasses and compressive residual stresses and strains at the coating/substrate interface, outperforming the silica-based glasses counterparts...
December 1, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27911827/tau-prions-from-alzheimer-s-disease-and-chronic-traumatic-encephalopathy-patients-propagate-in-cultured-cells
#3
Amanda L Woerman, Atsushi Aoyagi, Smita Patel, Sabeen A Kazmi, Iryna Lobach, Lea T Grinberg, Ann C McKee, William W Seeley, Steven H Olson, Stanley B Prusiner
Tau prions are thought to aggregate in the central nervous system, resulting in neurodegeneration. Among the tauopathies, Alzheimer's disease (AD) is the most common, whereas argyrophilic grain disease (AGD), corticobasal degeneration (CBD), chronic traumatic encephalopathy (CTE), Pick's disease (PiD), and progressive supranuclear palsy (PSP) are less prevalent. Brain extracts from deceased individuals with PiD, a neurodegenerative disorder characterized by three-repeat (3R) tau prions, were used to infect HEK293T cells expressing 3R tau fused to yellow fluorescent protein (YFP)...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27895873/value-of-computerized-tomography-enterography-in-predicting-crohn-s-disease-activity-correlation-with-crohn-s-disease-activity-index-and-c-reactive-protein
#4
Eun Kyung Park, Na Yeon Han, Beom Jin Park, Deuk Jae Sung, Sung Beom Cho, Yoon Tae Jeen, Bora Keum, Min Ju Kim
BACKGROUND: The accurate evaluation of Crohn's disease activity is important for the treatment of the disease and for monitoring the response. Computerized tomography (CT) enterography is a useful imaging modality that reflects enteric inflammation, as well as extramural complications. OBJECTIVES: The aim of this study was to evaluate the correlation between CT enterographic (CTE) findings of active Crohn's disease and the Crohn's disease activity index (CDAI) and C-reactive protein (CRP)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895429/potential-model-for-differential-diagnosis-between-crohn-s-disease-and-primary-intestinal-lymphoma
#5
Tian-Yu Zhang, Yun Lin, Rong Fan, Shu-Rong Hu, Meng-Meng Cheng, Mao-Chen Zhang, Li-Wen Hong, Xiao-Lin Zhou, Zheng-Ting Wang, Jie Zhong
AIM: To evaluate the usefulness of different parameters to differentiate Crohn's disease (CD) from primary intestinal lymphoma (PIL). METHODS: The medical records of 85 patients with CD and 56 patients with PIL were reviewed retrospectively. Demographic, clinical, laboratory, endoscopic, and computed tomographic enterography (CTE) parameters were collected. The univariate value of each parameter was analyzed. A differentiation model was established by pooling all the valuable parameters...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27885799/the-c-terminal-extension-of-mycobacterium-tuberculosis-hsp16-3-regulates-its-oligomerization-subunit-exchange-dynamics-and-chaperone-function
#6
Alok Kumar Panda, Ayon Chakraborty, Sandip Kumar Nandi, Abhishek Kaushik, Ashis Biswas
Mycobacterium tuberculosis is a human pathogen that secretes a major immunodominant antigen namely Hsp16.3 throughout the course of infection. It belongs to small heat shock protein family and exhibits molecular chaperone function which is important for the growth and survival of M. tuberculosis in host cell macrophages. The importance of the N-terminal region on the structure and chaperone function of Hsp16.3 is well understood. However, the effect of the C-terminal region on these properties is far from clear...
November 25, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27885490/localized-cortical-chronic-traumatic-encephalopathy-pathology-after-single-severe-axonal-injury-in-human-brain
#7
Sharon B Shively, Sarah L Edgerton, Diego Iacono, Dushyant P Purohit, Bao-Xi Qu, Vahram Haroutunian, Kenneth L Davis, Ramon Diaz-Arrastia, Daniel P Perl
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild impact traumatic brain injury from contact sports. Recently, a consensus panel defined the pathognomonic lesion for CTE as accumulations of abnormally hyperphosphorylated tau (p-tau) in neurons (neurofibrillary tangles), astrocytes and cell processes distributed around small blood vessels at sulcal depths in irregular patterns within the cortex. The pathophysiological mechanism for this lesion is unknown. Moreover, a subset of CTE cases harbors cortical β-amyloid plaques...
November 24, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27882099/correlations-of-smoking-with-cumulative-total-dust-exposure-and-cumulative-abnormal-rate-of-pulmonary-function-in-coal-mine-workers
#8
Qing-Zeng Qian, Xiang-Ke Cao, Fu-Hai Shen, Qian Wang
The present study aimed to investigate the correlation of smoking with cumulative total dust exposure (CTE) and cumulative abnormal rate of pulmonary function in coal-mine workers. A total of 376 coal-mine workers were recruited as the observational group, while 179 healthy workers in other industries were selected as the control group. All the workers underwent pulmonary function testing to determine their forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and FEV1/FVC, in order to compare the abnormal pulmonary function between the two groups...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881655/porcine-reproductive-and-respiratory-syndrome-virus-nsp1%C3%AE-inhibits-nf-%C3%AE%C2%BAb-activation-by-targeting-linear-ubiquitin-chain-assembly-complex-lubac
#9
Huiyuan Jing, Liurong Fang, Zhen Ding, Dang Wang, Wenqi Hao, Li Gao, Wenting Ke, Huanchun Chen, Shaobo Xiao
: Linear ubiquitination, a newly discovered posttranslational modification, is catalyzed by the linear ubiquitin chain assembly complex (LUBAC), which is composed of three subunits: one catalytic subunit HOIP and two accessory molecules, HOIL-1L and SHARPIN. Accumulating evidence suggests that linear ubiquitination plays a crucial role in innate immune signaling and especially in the activation of the NF-κB pathway by conjugating linear polyubiquitin chains to NF-κB essential modulator (NEMO, also called IKKγ), the regulatory subunit of the IKK complex...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27875355/novel-mutations-in-epcam-cause-congenital-tufting-enteropathy
#10
Wenjuan Tang, Taosheng Huang, Zhongyao Xu, Ying Huang
BACKGROUND AND AIMS: Congenital tufting enteropathy (CTE) is a rare autosomal recessive form of intractable diarrhea of infancy. Patients develop chronic diarrhea within days after birth, leading to severe malabsorption and significant mortality. CTE is characterized by subtotal villous atrophy with crypt hyperplasia. Typical features include abnormal villi in the intestinal epithelium and disorganization of surface enterocytes with focal crowding, resembling tufts. The pathogenesis of CTE remains poorly understood...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27859557/estimation-of-conditional-and-marginal-odds-ratios-using-the-prognostic-score
#11
David Hajage, Yann De Rycke, Guillaume Chauvet, Florence Tubach
Introduced by Hansen in 2008, the prognostic score (PGS) has been presented as 'the prognostic analogue of the propensity score' (PPS). PPS-based methods are intended to estimate marginal effects. Most previous studies evaluated the performance of existing PGS-based methods (adjustment, stratification and matching using the PGS) in situations in which the theoretical conditional and marginal effects are equal (i.e., collapsible situations). To support the use of PGS framework as an alternative to the PPS framework, applied researchers must have reliable information about the type of treatment effect estimated by each method...
November 17, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27853132/traumatic-brain-injuries
#12
Kaj Blennow, David L Brody, Patrick M Kochanek, Harvey Levin, Ann McKee, Gerard M Ribbers, Kristine Yaffe, Henrik Zetterberg
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury - the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available...
November 17, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27834536/progression-of-tau-pathology-within-cholinergic-nucleus-basalis-neurons-in-chronic-traumatic-encephalopathy-a-chronic-effects-of-neurotrauma-consortium-study
#13
Elliott J Mufson, Sylvia E Perez, Muhammad Nadeem, Laura Mahady, Nicholas M Kanaan, Eric E Abrahamson, Milos D Ikonomovic, Fiona Crawford, Victor Alvarez, Thor Stein, Ann C McKee
OBJECTIVE: To test the hypothesis that the nucleus basalis of Meynert (nbM), a cholinergic basal forebrain (CBF) cortical projection system, develops neurofibrillary tangles (NFTs) during the progressive pathological stages of chronic traumatic encephalopathy (CTE) in the brain of athletes. METHOD: To characterize NFT pathology, tau-antibodies marking early, intermediate and late stages of NFT development in CBF tissue obtained at autopsy from eighteen former athletes and veterans with a history of repetitive mild traumatic brain injury (TBI) were used...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27829969/chronic-traumatic-encephalopathy-in-athletes-involved-with-high-impact-sports
#14
Cyrus Safinia, Eric M Bershad, H Brent Clark, Karen SantaCruz, Naila Alakbarova, Jose I Suarez, Afshin A Divani
BACKGROUND AND PURPOSE: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease occurring most commonly in athletes and is caused by repeated concussive or subconcussive blows to the head. The main purpose of this review is to evaluate the published literature on chronic traumatic encephalopathy (CTE) in athletes participating in high-impact sports. In particular, we highlight the significance of concussive and subconcussive impacts in multiple sports, elucidate the differences between clinical/pathological features of CTE and related neurodegenerative diseases, and provide an explanation for the variation in clinical presentation between athletes of different sports...
October 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/27829172/disordered-app-metabolism-and-neurovasculature-in-trauma-and-aging-combined-risks-for-chronic-neurodegenerative-disorders
#15
REVIEW
Milos D Ikonomovic, Zhiping Mi, Eric E Abrahamson
Traumatic brain injury (TBI), advanced age, and cerebral vascular disease are factors conferring increased risk for late onset Alzheimer's disease (AD). These conditions are also related pathologically through multiple interacting mechanisms. The hallmark pathology of AD consists of pathological aggregates of amyloid-β (Aβ) peptides and tau proteins. These molecules are also involved in neuropathology of several other chronic neurodegenerative diseases, and are under intense investigation in the aftermath of TBI as potential contributors to the risk for developing AD and chronic traumatic encephalopathy (CTE)...
November 6, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27828128/analytical-solution-of-the-correlation-transport-equation-with-static-background-beyond-diffuse-correlation-spectroscopy
#16
Tiziano Binzoni, André Liemert, Alwin Kienle, Fabrizio Martelli
The correlation transport equation (CTE) is the natural generalization of the theory for diffusion correlation spectroscopy and represents a more precise model when dealing with measurements of particle movement in fluids or red blood cell flow in biological tissues. Unfortunately, the CTE is not methodically used due to the complexity of finding solutions. It is shown that actually a very simple modification of the theory/software for the solution of the radiative transport equation allows one to obtain exact solutions of the CTE...
October 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27815395/chronic-traumatic-encephalopathy-like-abnormalities-in-a-routine-neuropathology-service
#17
Shawna Noy, Sherry Krawitz, Marc R Del Bigio
Chronic traumatic encephalopathy (CTE) has been described mainly in professional athletes and military personnel and is characterized by deposition of hyperphosphorylated tau at the depths of cortical sulci and around blood vessels. To assess CTE-like changes in a routine neuropathology service, we prospectively examined 111 brains (age 18-60 years). The presence of tau-immunoreactive deposits was staged using guidelines described by others and was correlated with the medical history. 72/111 cases were negative for CTE-like changes; 34/111 were CTE stage <1; 3/111 were CTE stage 1; and 2/111 were CTE stage 2...
November 4, 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27802733/dilatometer-setup-for-low-coefficient-of-thermal-expansion-materials-measurements-in-the-140-k-250-k-temperature-range
#18
Ruven Spannagel, Ines Hamann, Josep Sanjuan, Thilo Schuldt, Martin Gohlke, Ulrich Johann, Dennis Weise, Claus Braxmaier
Space applications demand light weight materials with excellent dimensional stability for telescopes, optical benches, optical resonators, etc. Glass-ceramics and composite materials can be tuned to reach very low coefficient of thermal expansion (CTE) at different temperatures. In order to determine such CTEs, very accurate setups are needed. Here we present a dilatometer that is able to measure the CTE of a large variety of materials in the temperature range of 140 K to 250 K. The dilatometer is based on a heterodyne interferometer with nanometer noise levels to measure the expansion of a sample when applying small amplitude controlled temperature signals...
October 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27802274/topology-cross-frequency-and-same-frequency-band-interactions-shape-the-generation-of-phase-amplitude-coupling-in-a-neural-mass-model-of-a-cortical-column
#19
Roberto C Sotero
Phase-amplitude coupling (PAC), a type of cross-frequency coupling (CFC) where the phase of a low-frequency rhythm modulates the amplitude of a higher frequency, is becoming an important indicator of information transmission in the brain. However, the neurobiological mechanisms underlying its generation remain undetermined. A realistic, yet tractable computational model of the phenomenon is thus needed. Here we analyze a neural mass model of a cortical column, comprising fourteen neuronal populations distributed across four layers (L2/3, L4, L5 and L6)...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27793189/microglial-neuroinflammation-contributes-to-tau-accumulation-in-chronic-traumatic-encephalopathy
#20
Jonathan D Cherry, Yorghos Tripodis, Victor E Alvarez, Bertrand Huber, Patrick T Kiernan, Daniel H Daneshvar, Jesse Mez, Philip H Montenigro, Todd M Solomon, Michael L Alosco, Robert A Stern, Ann C McKee, Thor D Stein
The chronic effects of repetitive head impacts (RHI) on the development of neuroinflammation and its relationship to chronic traumatic encephalopathy (CTE) are unknown. Here we set out to determine the relationship between RHI exposure, neuroinflammation, and the development of hyperphosphorylated tau (ptau) pathology and dementia risk in CTE. We studied a cohort of 66 deceased American football athletes from the Boston University-Veteran's Affairs-Concussion Legacy Foundation Brain Bank as well as 16 non-athlete controls...
October 28, 2016: Acta Neuropathologica Communications
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