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https://www.readbyqxmd.com/read/28454276/microrna-134-reverses-multidrug-resistance-in-human-lung-adenocarcinoma-cells-by-targeting-foxm1
#1
Jipeng Li, Ying Chen, Mingwei Jin, Jianhua Wang, Shanfeng Li, Zhe Chen, Wanjun Yu
Multidrug resistance (MDR) is the primary barrier to the success of chemotherapy for lung adenocarcinoma. MicroRNA (miR)-134, which is downregulated in lung adenocarcinoma, influences cell proliferation, apoptosis and invasion of lung adenocarcinoma. However, the function of miR-134 in the MDR of lung adenocarcinoma remains unclear. In the present study, it was identified that miR-134 expression is significantly downregulated in A549/cisplatin MDR lung adenocarcinoma cells, as compared with A549 parental cells...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453641/phenotypic-and-genetic-analysis-of-the-leopard-complex-spotting-in-noriker-horses
#2
Thomas Druml, Gertrud Grilz-Seger, Markus Neuditschko, Barbara Neuhauser, Gottfried Brem
Genetic analyses of coat colors are frequently restricted to subjectively categorized phenotype information. The aim of this study was to develop a method to numerically quantify the variability of leopard complex spotting phenotypes introducing tools from image analysis. Generalized Procrustes Analysis eliminates systematic errors due to imaging process. The binarization of normalised images and the application of Principal Component Analysis on the derived pixel matrices, transform pixel information into numerical data space...
April 27, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28449362/duration-and-exclusiveness-of-breastfeeding-and-risk-of-childhood-atopic-diseases
#3
Niels J Elbert, Evelien R van Meel, Herman T den Dekker, Nicolette W de Jong, Tamar E C Nijsten, Vincent W V Jaddoe, Johan C de Jongste, Suzanne G M A Pasmans, Liesbeth Duijts
BACKGROUND: Breastfeeding may have immune modulatory effects that influence the development of childhood allergic sensitization and atopic diseases. We aimed to examine the associations of breastfeeding with childhood allergic sensitization, inhalant or food allergy and eczema, and whether any association was affected by disease-related modification of the exposure or modified by maternal history of maternal history of allergy, eczema or asthma. METHODS: This study among 5,828 children was performed in a population-based prospective cohort from fetal life onwards...
April 27, 2017: Allergy
https://www.readbyqxmd.com/read/28449355/father-child-interactions-at-3-months-and-24-months-contributions-to-children-s-cognitive-development-at-24-months
#4
Vaheshta Sethna, Emily Perry, Jill Domoney, Jane Iles, Lamprini Psychogiou, Natasha E L Rowbotham, Alan Stein, Lynne Murray, Paul G Ramchandani
The quality of father-child interactions has become a focus of increasing research in the field of child development. We examined the potential contribution of father-child interactions at both 3 months and 24 months to children's cognitive development at 24 months. Observational measures of father-child interactions at 3 and 24 months were used to assess the quality of fathers' parenting (n = 192). At 24 months, the Mental Developmental Index (MDI) of the Bayley Scales of Infant Development, Second Edition (N...
April 27, 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28448820/is-there-a-link-between-biological-parents-insight-into-their-offspring-s-schizophrenia-and-their-cognitive-functioning-expressed-emotion-and-knowledge-about-disorder
#5
Alexandra Macgregor, Joanna Norton, Stéphane Raffard, Delphine Capdevielle
BACKGROUND: Recent studies suggest that parents' awareness of their offspring's schizophrenia could influence their offspring's insight. Low patient insight is linked to impairment of specific cognitive abilities, and biological parents of schizophrenia patients have impaired capacities in these same domains. However, little is known about what specific socio-demographic, affective or cognitive factors may influence biological parents' awareness of their offspring's disease. METHOD: Data were drawn from 41 patient-parent dyads...
April 13, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28448537/mapping-of-quantitative-trait-loci-associated-with-resistance-to-net-form-net-blotch-pyrenophora-teres-f-teres-in-a-doubled-haploid-norwegian-barley-population
#6
Ronja Wonneberger, Andrea Ficke, Morten Lillemo
Barley net blotch caused by the necrotrophic fungus Pyrenophora teres is a major barley disease in Norway. It can cause grain shriveling and yield losses, and resistance in currently grown cultivars is insufficient. In this study, a set of 589 polymorphic SNP markers was used to map resistance loci in a population of 109 doubled haploid lines from a cross between the closely related Norwegian cultivars Arve (moderately susceptible) and Lavrans (moderately resistant). Resistance to three net form net blotch (P...
2017: PloS One
https://www.readbyqxmd.com/read/28448458/does-an-empty-nest-affect-elders-health-empirical-evidence-from-china
#7
Min Gao, Yanyu Li, Shengfa Zhang, Linni Gu, Jinsui Zhang, Zhuojun Li, Weijun Zhang, Donghua Tian
The "empty-nest" elderly family has become increasingly prevalent among old people in China. This study aimed to explore the causality between empty nests and elders' health using effective instrumental variables, including "whether old parents talk with their families when they are upset" and "ownership of housing". The results showed that empty nests had a significantly adverse influence on elders' physical health, cognitive ability and psychological health. Furthermore, urban elders' cognitive ability was more influenced by empty nests than that of rural elders...
April 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28446886/parenting-and-temperament-influence-on-school-success-in-9-13-year-olds
#8
Purificación Checa, Alicia Abundis-Gutierrez
Children spend a lot of time with their parents who are the first agents that educate them. The parenting style implemented in the family influences other contexts outside home such as the school. There is evidence that a positive parenting style has an influence on school success. However, there are other variables related to school success, for example, temperament. The influence of parenting decreases with age as children develop abilities to self-regulate without parents' external control. The aim of the present study was to evaluate the contribution of parenting style and temperament in 9-13 years old children on both academic performance and school adjustment skills...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28446885/the-impact-of-inattention-hyperactivity-impulsivity-symptoms-and-executive-functions-on-learning-behaviors-of-children-with-adhd
#9
Carla Colomer, Carmen Berenguer, Belén Roselló, Inmaculada Baixauli, Ana Miranda
Children diagnosed with attention deficit/hyperactivity disorder (ADHD) are at risk of experiencing lower academic achievement compared to their peers without ADHD. However, we have a limited understanding of the mechanisms underlying this association. Both the symptoms of the disorder and the executive functions can negatively influence learning behaviors, including motivation, attitude toward learning, or persistence, key aspects of the learning process. The first objective of this study was to compare different components of learning behaviors in children diagnosed with ADHD and typically developing (TD) children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28445878/differential-allelic-expression-of-htr1b-in-suicide-victims-genetic-and-epigenetic-effect-of-the-cis-acting-variants
#10
Ali Bani-Fatemi, Aaron Howe, Clement Zai, James L Kennedy, John Vincent, John Strauss, Albert Wong, Vincenzo De Luca
OBJECTIVES: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. METHODS: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain collection. Second, we tested common variants in the HTR1B promoter for linkage disequilibrium (LD) with the C861G variant in an unrelated sample of suicide attempters (SA; n = 38) and non-SA (NSA; n = 42)...
April 27, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28444813/optimism-and-positive-and-negative-feelings-in-parents-of-young-children-with-developmental-delay
#11
E Kurtz-Nelson, L L McIntyre
BACKGROUND: Parents' positive and negative feelings about their young children influence both parenting behaviour and child problem behaviour. Research has not previously examined factors that contribute to positive and negative feelings in parents of young children with developmental delay (DD). METHOD: The present study sought to examine whether optimism, a known protective factor for parents of children with DD, was predictive of positive and negative feelings for these parents...
April 26, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28444733/hybridization-increases-mitochondrial-production-of-reactive-oxygen-species-in-sunfish
#12
Sherry N N Du, Fariborz Khajali, Neal J Dawson, Graham R Scott
Mitochondrial dysfunction and oxidative stress have been suggested to be possible mechanisms underlying hybrid breakdown, as a result of mito-nuclear incompatibilities in respiratory complexes of the electron transport system. However, it remains unclear whether hybridization increases the production of reactive oxygen species (ROS) by mitochondria. We used high-resolution respirometry and fluorometry on isolated liver mitochondria to examine mitochondrial physiology and ROS emission in naturally occurring hybrids of pumpkinseed (Lepomis gibbosus) and bluegill (L...
April 26, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28444518/video-based-approach-to-engaging-parents-into-a-preventive-parenting-intervention-for-divorcing-families-results-of-a-randomized-controlled-trial
#13
Emily B Winslow, Sanford Braver, Robert Cialdini, Irwin Sandler, Jennifer Betkowski, Jenn-Yun Tein, Liza Hita, Mona Bapat, Lorey Wheeler, Monique Lopez
The public health impact of evidence-based, preventive parenting interventions has been severely constrained by low rates of participation when interventions are delivered under natural conditions. It is critical that prevention scientists develop effective and feasible parent engagement methods. This study tested video-based methods for engaging parents into an evidence-based program for divorcing parents. Three alternative versions of a video were created to test the incremental effectiveness of different theory-based engagement strategies based on social influence and health behavior models...
April 25, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28443686/combined-clinician-parent-delivery-of-rapid-syllable-transition-rest-treatment-for-childhood-apraxia-of-speech
#14
Donna C Thomas, Patricia McCabe, Kirrie J Ballard
PURPOSE: Although speech-language pathologists use parent-delivered home-practice, little is known about the quality of this practice and its relation to treatment efficacy. This study reports both treatment outcomes and fidelity following combined clinician-parent delivery of Rapid Syllable Transition (ReST) treatment. METHOD: Five children aged 5:1-11:7 with childhood apraxia of speech received 12 treatment sessions; six clinic-based and six at home, using multiple baselines across participants design...
April 26, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28443367/preventing-risky-behaviours-among-young-adolescents-in-eastern-democratic-republic-of-congo-a-qualitative-study
#15
Anjalee Kohli, Mitima Mpanano Remy, Arsene Kajabika Binkurhorhwa, Clovis Murhula Mitima, Alfred Bacikenge Mirindi, Nadine Bufole Mwinja, Jean Heri Banyewesize, Gisele Mushengezi Ntakwinja, Nancy A Perrin, Nancy Glass
This qualitative study explores and describes adolescent risk behaviours, specifically consumption of alcohol and use of violence; the perceived consequences of these behaviours on future well-being and relationships; and collaboratively identifies the essential components of a prevention intervention for risk behaviours (alcohol use, violence) among young adolescents while strengthening the protective individual and relationship factors in post-conflict Democratic Republic of Congo. One-on-one in-depth interviews were conducted with 28 male and female youth, 20 parents/guardians and 20 stakeholders in three rural villages of South Kivu Province...
April 26, 2017: Global Public Health
https://www.readbyqxmd.com/read/28443159/genetic-markers-for-adolescent-idiopathic-scoliosis-on-chromosome-19p13-3-among-saudi-arabian-girls
#16
Abdallah Ahmad Al-Othman, Mir Sadat-Ali, Ahmed Sh Amer, Dakheel A Al-Dakheel
STUDY DESIGN: Prospective case-controlled study. PURPOSE: This study aimed to assess genetic influence in Saudi Arabian children with adolescent idiopathic scoliosis (AIS). OVERVIEW OF LITERATURE: The genetic locus linked to chromosome 19p for idiopathic scoliosis has been described. A pilot study conducted at King Fahd Hospital of the University, Al-Khobar showed that three microsatellite markers (D19S216, D19S894, and DS1034) of chromosome 19p13...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28443056/concerns-mental-health-and-quality-of-life-in-living-kidney-donation-parent-donor-candidates-worry-less-about-themselves
#17
M Ángeles Pérez-San-Gregorio, Agustín Martín-Rodríguez, Asunción Luque-Budia, Rupert Conrad
Even though the majority of living kidney donor candidates appear in good mental health and show few concerns little is known concerning the influence of the type of donor-recipient relationship on donor candidates' specific concerns with regard to kidney donation. 136 donor candidates at Virgen del Rocío University Hospital of Seville filled in the Scale of Concerns Regarding Living Kidney Donation of whom 105 donor candidates and their corresponding recipients (105 patients with End-Stage Renal Disease) were further evaluated with regard to mental health (Hospital Anxiety and Depression Scale, Beck Depression Inventory-II) and quality of life (SF-36 Health Survey)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28442229/changing-attitudes-to-childhood-immunisation-in-english-parents
#18
Helen Campbell, Angela Edwards, Louise Letley, Helen Bedford, Mary Ramsay, Joanne Yarwood
OBJECTIVES: We undertook a national survey of parental attitudes to childhood vaccinations and compared results with those in earlier comparable surveys covering a 10year period. METHODS: We randomly selected 275 nationally representative sampling locations in England. Interviewers identified eligible primary care givers (referred to as parents) of children aged from 2months to <5years and conducted home-based interviews between January and April 2015. We aimed to recruit 1000 parents of children aged 0-2years and 1000 of children aged 3-4years...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28441103/perceptions-of-abusive-parenting-behaviors-a-preliminary-exploration-into-the-underrecognition-of-mother-daughter-sexual-abuse
#19
Christine J Hatchard, Jamie L Goodwin, Eryn Siddall, Lauren Muniz
The current study examined the influence of the sex of the parent and the sex of the child on perceptions of sexually abusive behaviors. Vignettes illustrating different forms of sexual abuse were rated by 124 participants, with the different parent-child pairs (mother-daughter, mother-son, father-daughter, father-son) substituted into the vignettes being the only difference between groups. Two-way between subjects ANOVAs revealed that sexually abusive behaviors by mothers were perceived as less damaging to child victims (F (1, 120 = 7...
April 25, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28440745/primaquine-in-plasma-and-methemoglobinemia-in-patients-with-malaria-due-to-plasmodium-vivax-in-the-brazilian-amazon-basin
#20
José Luiz Vieira, Michelle E S Ferreira, Michelle V D Ferreira, Margarete M Gomes
Primaquine is the only licensed drug available for the elimination of Plasmodium vivax hypnozoites. Methemoglobinemia is currently reported in the course of treatment. There is evidence that metabolites of primaquine formed by the cytochrome pathway are responsible for methemoglobin formation; a genetic polymorphism of cytochrome isoforms; and a potential influence of gender in the activities of these enzymes requiring the establishment of dose × response curves profiles in different population groups. Concentrations of primaquine in plasma and methemoglobin levels were investigated in 54 patients with malaria due to P...
April 3, 2017: American Journal of Tropical Medicine and Hygiene
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