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Parenting coordination

Sarah Theiner, Márkó Grabarics, Luis Galvez, Hristo P Varbanov, Nadine S Sommerfeld, Markus Galanski, Bernhard K Keppler, Gunda Koellensperger
The potential advantage of platinum(iv) complexes as alternatives to classical platinum(ii)-based drugs relies on their kinetic stability in the body before reaching the tumor site and on their activation by reduction inside cancer cells. In this study, an analytical workflow has been developed to investigate the reductive biotransformation and kinetic inertness of platinum(iv) prodrugs comprising different ligand coordination spheres (respectively, lipophilicity and redox behavior) in whole human blood. The distribution of platinum(iv) complexes in blood pellets and plasma was determined by inductively coupled plasma-mass spectrometry (ICP-MS) after microwave digestion...
March 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Dominique Silva Silveira, Luis Filipe Gomes Barbosa Ferreira Lemos, Rafael Miranda Tassitano, Maria Teresa Cattuzzo, Anderson Henry Pereira Feitoza, Luisa Maria Seara Moreira Carneiro Aires, Jorge Augusto Pinto Silva Mota, Clarice Maria de Lucena Martins
This study evaluated the effect of a multi-component intervention on motor performance (MP) and metabolic risk markers (MRM) in overweight/obese youth. A secondary aim was to examine whether changes in MP are associated to changes in MRM. A 3-month multi-component intervention was performed, consisting of physical exercise sessions (twice/week;1h), nutritional education sessions (once/month), and parental support (twice/week). The sample included 35 volunteers (7-13 y.o), allocated to intervention (INT, n = 17) and control (CONT, n = 18) group...
March 20, 2018: Journal of Sports Sciences
Melanie R Keats, Kelsey Shea, Louise Parker, Samuel A Stewart, Annette Flanders, Mark Bernstein
Despite support for the provision of a survivorship care plan (SCP) to every cancer survivor, there is a lack of understanding of the needs and preferences of key stakeholders. We examined perspectives of a novel personalized SCP for childhood cancer survivors (CCS), their family, and family physicians (FP). We conducted semi-structured telephone interviews with a purposefully selected sample of CCS, parents/guardians, and FPs. Data included responses to stakeholder cancer care information needs, concerns with or gaps in communication, the perceived role of the FP in the long-term management of CCS care, utility of the SCP, preferred format, and suggestions for improvement...
March 19, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Lisa G Sorensen, Katie Neighbors, Regina M Hardison, Kathleen M Loomes, James W Varni, Vicky L Ng, Robert H Squires, Estella M Alonso
OBJECTIVE: To determine health-related quality of life (HRQoL) and neurocognitive impairment in survivors of pediatric acute liver failure (PALF). STUDY DESIGN: A longitudinal prospective study was conducted. At 6 and 12 months after PALF presentation, surveys of HRQoL were completed for 2- to 19-year-olds and executive functioning for ages 2-16 years. At 12 months, patients 3-16 years of age completed neurocognitive testing. HRQoL scores were compared with a healthy, matched sample...
March 16, 2018: Journal of Pediatrics
Linji Zhang, Yang Ren, Xiuru Liu, Fei Han, Kenneth Evans-Lutterodt, Hongyan Wang, Yali He, Junlong Wang, Yong Zhao, Wenge Yang
Amorphous sulfur was prepared by rapid compression of liquid sulfur at temperatures above the λ-transition for to preserve the high-temperature liquid structure. We conducted synchrotron high-energy X-ray diffraction and Raman spectroscopy to diagnose the structural evolution of amorphous sulfur from room temperature to post-λ-transition temperature. Discontinuous changes of the first and second peaks in atomic pair-distribution-function, g(r), were observed during the transition from amorphous to liquid sulfur...
March 14, 2018: Scientific Reports
Takako Osaki, Cynthia Zaman, Hideo Yonezawa, Yingsong Lin, Masumi Okuda, Eriko Nozaki, Fuhito Hojo, Satoshi Kurata, Tomoko Hanawa, Shogo Kikuchi, Shigeru Kamiya
Helicobacter pylori is a causative pathogen of chronic gastritis, gastric ulcer disease, and gastric cancer. Humans are known to be a natural host for H. pylori and tend to acquire the pathogen before the age of 5 years. The infection may then persist lifelong if eradication therapy is not applied. One of the modes of transmission of H. pylori is between family members, and therefore, the presence of infected family members is an important risk factor in children. However, other environmental factors have not been fully analyzed...
2018: Frontiers in Immunology
Byeongyoon Kim, Aram Oh, Mrinal Kanti Kabiraz, Youngmin Hong, Jinwhan Joo, Hionsuck Baik, Sang-Il Choi, Kwangyeol Lee
A layered β-NiOOH crystal with under-coordinated facets is an active and economically viable non-noble catalyst for the oxygen evolution reaction (OER) in alkaline electrolytes. However, it is extremely difficult to enclose the β-NiOOH crystal with under-coordinated facets due to its inevitable crystal transformation to γ-NiOOH, resulting in the exfoliation of the catalytic surfaces. Herein, we demonstrate {111}-faceted Ni octahedra as the parent substrates which surfaces are easily transformed to catalytically active β-NiOOH during the alkaline OER...
March 7, 2018: ACS Applied Materials & Interfaces
Venla Lehti, David Gyllenberg, Auli Suominen, Andre Sourander
AIM: We examined the association between having at least one parent born abroad and being diagnosed with a developmental disorder related to speech and language, academic skills or coordination. METHODS: This nested case-control study was based on Finnish population records for 1996-2007. Cases from the Finnish Hospital Discharge Register were diagnosed with developmental disorders of speech and language, academic skills and coordination by the end of 2012. We identified 28,192 cases and 106,616 matched controls...
March 5, 2018: Acta Paediatrica
Carolyn Allshouse, Meg Comeau, Rylin Rodgers, Nora Wells
This article, written by a group of experienced parents of children with medical complexity (CMC), provides an overview of the demands of managing care from their unique perspective. The article articulates why attention to understanding the challenges that families of CMC face with a fragmented health care system, inadequate health insurance coverage, deficits in the delivery of medical care, and problems accessing other critical services (as well as lack of support for children and adolescents in developing and exercising self-management skills) are vital to efforts to improve the current system and positively impact the life course of vulnerable populations...
March 2018: Pediatrics
Renyu Zhang, Gen Xu, Jiansheng Li, Jianbing Yan, Huihui Li, Xiaohong Yang
Genetic relationships among Chinese maize germplasms reveal historical trends in heterotic patterns from Chinese breeding programs and identify line Dan340 as a potential genome donor for elite inbred line Zheng58. The characterization of the genetic relationships, heterotic patterns and breeding history of lines in maize breeding programs allows breeders to efficiently use maize germplasm for line improvement over time. In this study, 269 temperate inbred lines, most of which have been widely used in Chinese maize breeding programs since the 1970s, were genotyped using the Illumina MaizeSNP50 BeadChip, which contains 56,110 single-nucleotide polymorphisms...
February 28, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Dhong Hyun Lee, Homayon Ghiasi
We found previously that altering macrophage polarization toward M2 responses by injection of colony stimulating factor-1 (CSF-1) was more effective in reducing both primary and latent infection in HSV-1 ocularly infected mice than M1 polarization by IFN-γ injection. Cytokines can coordinately regulate macrophage and TH responses, with IL-4 inducing TH 2 as well as M2 responses and IFN-γ inducing TH 1 as well as M1 responses. We have now differentiated the contributions of these immune compartments on protection against latency/reactivation and corneal scarring by comparing the effects of infection with recombinant HSV-1 in which the latency associated transcript (LAT) gene was replaced with either the IL-4 (HSV-IL-4) or IFN-γ (HSV-IFN-γ) genes using infection with the parental (LAT-negative) virus as a control...
February 28, 2018: Journal of Virology
Jan Wilhelm, Ximena Calvo, Carola Escobar, Gabriela Moreno, Liliana Véliz, Rodolfo Villena, Marcela Potin
Although vaccines have had a tremendous impact in public health they are questioned by certain groups that consider them unnecessary or unsafe and argue in favor of the right to decide to be vaccinated or not. However vaccines must have special considerations because unlike other medical decisions, not vaccinating has consequences not only for the individual but also for other members of the community. Immunizing a high proportion of the population limits the circulation of an infectious agent attaining what is called herd immunity that protects the susceptible members of the group...
December 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Britt Frisk Pados, Suzanne M Thoyre, Jinhee Park
AIM: To determine reference values for the Child Oral and Motor Proficiency Scale (ChOMPS) based on healthy, typically-developing and typically-eating children between 6 months and 7 years old. METHODS: Parents of children 6 months to 7 years old (n=1057) completed the 63-item ChOMPS. Median, range, 5th and 10th percentiles were calculated for scores on the four subscales of the ChOMPS as well as the total score in each of 11 age groups. RESULTS: Age-based norm-reference values are reported...
February 27, 2018: Acta Paediatrica
Shefali Vaidya, Pragya Shukla, Shalini Tripathi, Eric Rivière, Talal Mallah, Gopalan Rajaraman, Maheswaran Shanmugam
A series of mononuclear tetrahedral cobalt(II) complexes with the general molecular formula [Co(L1 )2 X2 ] [where L1 = tetramethylthiourea ([(CH3 )2 N]2 C═S) and X = Cl (1), Br (2), and I (3)] were isolated, and their structures were characterized by single-crystal X-ray diffraction. The experimental direct-current magnetic data are excellently reproduced by fitting both χM T(T) and M(H) simultaneously using the spin Hamiltonian (SH) parameters D1 = -18.1 cm-1 and g1,iso = 2.26, D2 = -16.4 cm-1 and g2,iso = 2...
February 27, 2018: Inorganic Chemistry
M Mirza, A Krischer, M Stolley, S Magaña, M Martin
BACKGROUND: A large number of U.S. children are identified as having special health care needs (CSHCN). Despite parents' central role in managing their child's needs, many parents report difficulties in navigating service systems, finding information about their child's condition, and accessing health care and community resources. Therefore, there is a need for interventions that "activate" parents of children with special health care needs to increase their knowledge, skills, and confidence in managing, coordinating, and advocating for their child's needs...
February 27, 2018: Child: Care, Health and Development
Daniel Flynn, Mary Kells, Mary Joyce, Catalina Suarez, Conall Gillespie
BACKGROUND: In the Republic of Ireland, borderline personality disorder (BPD) is a feature of approximately 11-20% of clinical presentations to outpatient clinics within mental health services. These estimates are similar to other countries including the UK and USA. Dialectical behaviour therapy (DBT) is an intervention with a growing body of evidence that demonstrates its efficacy in treating individuals diagnosed with BPD. While a number of randomised controlled trials (RCTs) have demonstrated the efficacy of DBT, there is limited research which evaluates the effectiveness of this model when applied to real world settings...
February 26, 2018: BMC Psychiatry
Priscila Caçola, Michael Killian
BACKGROUND AND AIMS: One of the major concerns for Developmental Coordination Disorder (DCD) are the mental and physical consequences of the condition, especially as they relate to quality of life factors. Here, we examined health-related quality of life (HRQOL) in children with DCD, determined the association between two standardized parent reports, and compared HRQOL of our sample with DCD with the normative sample of each assessment for typically developing (TD) children and a sample of children with chronic health conditions...
February 23, 2018: Research in Developmental Disabilities
Marja Cantell, Suzanne Houwen, Marina Schoemaker
BACKGROUND: Early recognition of children at risk of Developmental Coordination Disorder (DCD) is important, but variability in motor development in preschool children affects the validity of instruments to reliably detect children at risk of DCD. AIMS: To investigate the age-related validity and reliability of the Dutch version of the Little Developmental Coordination Disorder Questionnaire (LDCDQ-NL). METHODS AND PROCEDURES: Two hundred and sixty 3- to 5-year old children were recruited in the Netherlands...
February 21, 2018: Research in Developmental Disabilities
Laura J Chavez, Connor Grannis, Millie Dolce, Deena J Chisolm
BACKGROUND: Caring for teens with special health care needs places physical and mental health burdens on parents, which can be exacerbated by the stresses of transitions to independence. Medical homes can improve teen transitions to greater self-management and reduce health care-related time and financial burdens for families. This analysis examines the association between parent-reported teen medical home status and caregiver health-related quality of life (HRQOL). METHODS: The study sample included parents/caregivers of teens with special health care needs, ages 15-18, recruited from a pediatric Medicaid accountable care organization who participated in a survey (response rate=40...
February 22, 2018: Academic Pediatrics
Elizabeth Radcliff, Elizabeth Crouch, Melissa Strompolis
INTRODUCTION: Adverse childhood experiences (ACEs) are traumatic events that occur in a child's life between birth and 18 years. Exposure to one or more ACE has been linked to participation in risky health behaviors and the experience of chronic health conditions in adulthood. The risk for poor outcomes increases as the number of ACEs experienced increases. This research investigates rural-urban differences in exposure to ACEs using a sample from a representative southern US state, South Carolina...
February 2018: Rural and Remote Health
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