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https://www.readbyqxmd.com/read/27913859/complex-genetics-architecture-contributes-to-salmonella-resistance-in-acb60-mice
#1
Sean Beatty, Leïla Rached-D'Astous, Danielle Malo
Human infection with Salmonella is of global public health concern. In low- and middle-income countries, Salmonella infection is a major source of disease in terms of both mortality and morbidity, while in high-income nations, the pathogen is an ongoing threat to food security. The outcome of infection with Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) in mouse models is dependent upon a coordinated and complex immune response. A panel of recombinant congenic strains (RCS) derived from the reciprocal double backcross of A/J and C57BL/6J mice has been screened for their susceptibility to Salmonella infection, and the RCS AcB60 was identified to be the most resistant strain to Salmonella infection, more resistant than the parental strain A/J...
December 2, 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/27911938/motion-plan-changes-predictably-in-dyadic-reaching
#2
Atsushi Takagi, Niek Beckers, Etienne Burdet
Parents can effortlessly assist their child to walk, but the mechanism behind such physical coordination is still unknown. Studies have suggested that physical coordination is achieved by interacting humans who update their movement or motion plan in response to the partner's behaviour. Here, we tested rigidly coupled pairs in a joint reaching task to observe such changes in the partners' motion plans. However, the joint reaching movements were surprisingly consistent across different trials. A computational model that we developed demonstrated that the two partners had a distinct motion plan, which did not change with time...
2016: PloS One
https://www.readbyqxmd.com/read/27911081/shared-decision-making-in-youth-mental-health-care-using-the-evidence-to-plan-treatments-collaboratively
#3
David A Langer, Amanda Jensen-Doss
The shared decision-making (SDM) model is one in which providers and consumers of health care come together as collaborators in determining the course of care. The model is especially relevant to youth mental health care, when planning a treatment frequently entails coordinating both youth and parent perspectives, preferences, and goals. The present article first provides the historical context of the SDM model and the rationale for increasing our field's use of SDM when planning psychosocial treatments for youth and families...
December 2, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27906716/infants-with-technology-dependence-facilitating-the-road-to-home
#4
Jennifer D Bowles, Amy J Jnah, Desi M Newberry, Carol A Hubbard, Tracey Roberston
BACKGROUND: The incidence of premature infants with complex medical needs, dependent upon medical technology at discharge, is on the rise in the United States. PURPOSE: Preparing the family for the hospital-to-home transition can be challenging due to the complex medical and emotional needs of the vulnerable infant and the volume of subspecialty services and equipment required. METHODS/SEARCH STRATEGY: Relevant articles from PubMed, Google Scholar, CINAHLFINDINGS/RESULTS:: There is an increasing incidence of technology dependent infants discharged from neonatal intensive care units in the United States...
December 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27901627/effects-of-pediatric-asthma-care-coordination-in-underserved-communities-on-parent-perceptions-of-care-and-asthma-management-confidence
#5
Mary R Janevic, Alan P Baptist, Tyra Bryant-Stephens, Marielena Lara, Victoria Persky, Gilberto Ramos-Valencia, Kimberly Uyeda, Rebecca Hazan, Ashley Garrity, Floyd J Malveaux
OBJECTIVE: Disparities by race and socioeconomic status persist in pediatric asthma morbidity, mortality, and treatment. Improving parent/provider communication and parents' asthma-management confidence may result in better asthma control in vulnerable populations. The Merck Childhood Asthma Network, Inc. funded an initiative to implement medical-social care coordination to improve asthma outcomes at sites in four low-income, urban communities (Los Angeles, CA; Philadelphia, PA; Chicago, IL; and San Juan, PR...
November 30, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27896838/children-with-medical-complexity-a-scoping-review-of-interventions-to-support-caregiver-stress
#6
REVIEW
H Edelstein, J Schippke, S Sheffe, S Kingsnorth
BACKGROUND: Caring for children with chronic and complex medical needs places extraordinary stress on parents and other family members. A scoping review was undertaken to identify and describe the full range of current interventions for reducing caregiver stress. METHODS: Applying a broad definition of caregiver stress, a systematic search of three scientific databases (CINAHL, Embase and Ovid Medline), a general internet search and hand searching of key peer-reviewed articles were conducted...
November 29, 2016: Child: Care, Health and Development
https://www.readbyqxmd.com/read/27895258/x-ray-crystallographic-insights-into-post-synthetic-metalation-products-in-a-metal-organic-framework
#7
Michael T Huxley, Campbell J Coghlan, Witold M Bloch, Alexandre Burgun, Christian J Doonan, Christopher J Sumby
Post-synthetic modification of metal-organic frameworks (MOFs) facilitates a strategic transformation of potentially inert frameworks into functionalized materials, tailoring them for specific applications. In particular, the post-synthetic incorporation of transition-metal complexes within MOFs, a process known as 'metalation', is a particularly promising avenue towards functionalizing MOFs. Herein, we describe the post-synthetic metalation of a microporous MOF with various transition-metal nitrates. The parent framework, 1: , contains free-nitrogen donor chelation sites, which readily coordinate metal complexes in a single-crystal to single-crystal transformation which, remarkably, can be readily monitored by X-ray crystallography...
January 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27883125/surface-induced-vibrational-modes-in-the-fluorescence-spectra-of-ptcda-adsorbed-on-the-kcl-100-and-nacl-100-surfaces
#8
A Paulheim, C Marquardt, M Sokolowski, M Hochheim, T Bredow, H Aldahhak, E Rauls, W G Schmidt
We report a combined experiment-theory study on low energy vibrational modes in fluorescence spectra of perylene-3,4,9,10-tetracarboxylic acid dianhydride (PTCDA) molecules. Using very low coverages, isolated molecules were adsorbed on terrace sites or at sites located at residual steps on (100) oriented alkali halide films (KCl and NaCl). The low energy modes couple to the optical transition only because the PTCDA molecule is geometrically distorted (C2v) upon adsorption on the surface; they would be absent for the parent planar (D2h) PTCDA molecule...
November 24, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27878068/genome-methylation-patterns-across-castes-and-generations-in-a-parasitoid-wasp
#9
Roei Shaham, Rachel Ben-Shlomo, Uzi Motro, Tamar Keasar
Environmental influences shape phenotypes within and across generations, often through DNA methylations that modify gene expression. Methylations were proposed to mediate caste and task allocation in some eusocial insects, but how an insect's environment affects DNA methylation in its offspring is yet unknown. We characterized parental effects on methylation profiles in the polyembryonic parasitoid wasp Copidosoma koehleri, as well as methylation patterns associated with its simple caste system. We used methylation-sensitive amplified fragment length polymorphism (MS-AFLP) to compare methylation patterns, among (1) reproductive and soldier larvae; and (2) offspring (larvae, pupae, and adults) of wasps that were reared at either high or low larval density and mated in the four possible combinations...
November 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27876052/implementing-the-united-kingdom-s-ten-year-teenage-pregnancy-strategy-for-england-1999-2010-how-was-this-done-and-what-did-it-achieve
#10
Alison Hadley, Roger Ingham, Venkatraman Chandra-Mouli
BACKGROUND: In 1999, the UK Labour Government launched a 10-year Teenage Pregnancy Strategy for England to address the country's historically high rates and reduce social exclusion. The goal was to halve the under-18 conception rate. This study explores how the strategy was designed and implemented, and the features that contributed to its success. METHODS: This study was informed by examination of the detailed documentation of the strategy, published throughout its 10-year implementation...
November 22, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27875781/long-term-pediatrician-outcomes-of-a-parent-led-curriculum-in-developmental-disabilities
#11
Bruce L Keisling, Elizabeth A Bishop, David A Kube, Jenness M Roth, Frederick B Palmer
: Previous research has demonstrated high satisfaction and perceived relevance of Project DOCC (Delivery of Chronic Care), a parent led curriculum in developmental disabilities, across a sample of medical residents. AIMS: The influence of such a training program on the clinical practices and professional activities of these residents once they are established in their careers as physicians, however, has not been studied; this was the aim of the present study. METHODS: An anonymous follow-up survey was designed and disseminated to physicians who participated in Project DOCC during their one-month developmental disabilities rotation as part of their pediatrics or medicine/pediatric residency between 2002 and 2010...
November 19, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27874270/neurodevelopmental-disorders-are-highly-over-represented-in-children-with-obesity-a-cross-sectional-study
#12
Elisabet Wentz, Anna Björk, Jovanna Dahlgren
OBJECTIVE: To investigate prevalence of neurodevelopmental disorders in children with obesity and to compare body mass index (BMI) and metabolic profile in the children. METHODS: Seventy-six children (37 girls, 39 boys) were consecutively recruited from a university outpatient clinic specialized in severe obesity. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD) were assessed using interviews and questionnaires...
November 22, 2016: Obesity
https://www.readbyqxmd.com/read/27872093/a-novel-platinum-ii-based-bifunctional-adc-linker-benchmarked-using-89zr-desferal-and-auristatin-f-conjugated-trastuzumab
#13
Niels J Sijbrandi, Eugen Merkul, Joey A Muns, Dennis Cj Waalboer, Kevin Adamzek, Marije Bolijn, Veronica Montserrat, Govert W Somsen, Rob Haselberg, Paul Jgm Steverink, Hendrik-Jan Houthoff, Guus A M S van Dongen
Greater control is desirable in the stochastic conjugation technology used to synthesize antibody-drug conjugates (ADCs). We have shown recently that a fluorescent dye can be stably conjugated to a monoclonal antibody (mAb) using a bifunctional platinum(II) linker. Here we describe the general applicability of this novel linker technology for the preparation of stable and efficacious ADCs. The ethylenediamineplatinum(II) moiety, herein called Lx®, was coordinated to Desferal® (DFO) or auristatin F (AF) to provide storable "semi-final" products, which were directly conjugated to unmodified mAbs...
November 21, 2016: Cancer Research
https://www.readbyqxmd.com/read/27871772/identifying-play-characteristics-of-pre-school-children-with-developmental-coordination-disorder-via-parental-questionnaires
#14
Sara Rosenblum, Pola Waissman, Gary W Diamond
: Motor coordination deficits that characterize children with Developmental Coordination Disorder (DCD) affect their quality of participation. The aim of the current study was to identify play characteristics of young children with DCD, compared to those of children with typical development in three dimensions: activity and participation, environmental factors and children's impairments. METHOD: Sixty-four children, aged four to six years, participated. Thirty were diagnosed as having DCD; the remaining 34 children were age, gender and socioeconomic level matched controls with typical development...
November 18, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27861963/cation-and-anion-substituted-potassium-manganese-phosphate-kmnp3-o9-luminescence-and-photocatalytic-studies
#15
C H Sudhakar Reddy, G Ravi, K Sreenu, Ravinder Guje, M Malathi, Muga Vithal
Phosphates as multi-functional materials were of vital importance in the environmental and energy fields. In the present work, a new cyclophosphate, potassium-manganese-phosphate (KMnP3 O9 ) (hereafter KMPO), was prepared by solid state method. Cations (Ag(+) and Cu(2+) ) and anion (N(3-) ) were substituted into KMPO lattice via ion-exchange and solid state methods respectively. The as-prepared materials were characterized by powder X-ray diffraction, SEM-EDS and UV-visible diffuse reflectance spectra. Rietveld refinement was carried out for parent material...
November 18, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27848005/neurocognitive-and-psychosocial-function-in-children-with-benign-external-hydrocephalus-beh-a-long-term-follow-up-study
#16
Rebecka Mikkelsen, Linn Nilsen Rødevand, Ulrikke Straume Wiig, Sverre Morten Zahl, Torhild Berntsen, Anne-Britt Skarbø, Arild Egge, Eirik Helseth, Stein Andersson, Knut Wester
INTRODUCTION: Long-term impact of benign external hydrocephalus (BEH) on cognition is largely unknown, and indication for neurosurgical CSF diversion procedure is debated. This study reports neuropsychological and psychosocial function in operated and non-operated BEH children. METHODS: Eighty-six children (76 males) between 8 and 18 years (mean 13.9) diagnosed with BEH before 12 months were included, of whom 30.2 % were operated. Participants completed neuropsychological tests and questionnaires covering quality of life (PedsQL) and executive function (BRIEF)...
November 15, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27833576/prenatal-intuitive-coparenting-behaviors
#17
Joëlle Darwiche, Elisabeth Fivaz-Depeursinge, Antoinette Corboz-Warnery
Micro-analytic research on intuitive parenting behaviors has shed light on the temporal dynamics of parent and child interactions. Observations have shown that parents possess remarkable implicit communicative abilities allowing them to adapt to the clues infants give and therefore stimulate the development of many of the infants' abilities, such as communication skills. This work focused on observing intuitive parenting behaviors that were synchronized and coordinated between the parents. We call them "prenatal intuitive coparenting behaviors" and used an observation task - the Prenatal Lausanne Trilogue Play procedure - to observe them...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27832925/ecological-validity-of-the-german-bruininks-oseretsky-test-of-motor-proficiency-2nd-edition
#18
Sabine Vinçon, Dido Green, Rainer Blank, Ekkehart Jenetzky
The diagnosis of Developmental Coordination Disorder (DCD) is based on poor motor coordination in the absence of other neurological disorders. In order to identify the presence of movement difficulties, a standardised motor assessment is recommended to determine the extent of movement problems which may contribute to deficits in daily task performance. A German version of the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (German BOT-2) was recently published. This study aimed to determine the ecological validity of the German BOT-2 by considering the relationship between assessment of fundamental motor skills with the BOT-2 and performance of everyday motor activities as evaluated by parents...
November 7, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27827497/hybrid-materials-based-on-novel-2d-lanthanide-coordination-polymers-covalently-bonded-to-amine-modified-sba-15-and-mcm-41-assembly-characterization-structural-features-thermal-and-luminescence-properties
#19
Jun Wang, Wei Dou, Alexander M Kirillov, Weisheng Liu, Cailing Xu, Ran Fang, Lizi Yang
Three novel 2D coordination polymers [Tb2(μ4-L)2(μ-HL)(μ-HCOO)(DEF)]n (Tb-L), [Eu(μ4-L)(L)(H2O)2]n (Eu-L), and [Nd(μ4-L)(L)(H2O)2]n (Nd-L) were assembled from the corresponding lanthanide(iii) nitrates and 5 methoxy-(4-benzaldehyde)-1,3-benzenedicarboxylic acid (H2L) as a main multifunctional building block bearing carboxylate and aldehyde functional groups, using H2O/DEF {DEF = N,N-diethylformamide} as a reaction medium. The obtained coordination polymers were isolated as stable microcrystalline solids and fully characterized by elemental analysis, FT-IR spectroscopy, TGA, BET, PXRD, and single-crystal X-ray diffraction methods...
November 9, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27814890/synthesis-characterization-and-binding-affinity-of-hydrosulfide-complexes-of-synthetic-iron-ii-porphyrinates
#20
Daniel J Meininger, Hadi D Arman, Zachary J Tonzetich
The binding and reactivity of the hydrosulfide ion (HS(-)) to iron(II) porphyrinates has been examined for several synthetic meso-tetraphenylporphine (TPP) derivatives. In all cases, HS(-) coordinates to the iron centers in a 1:1 stoichiometry with formation constants (Kf) that reflect the electronic characteristics of the porphyrinate ligands. In the case of the F8TPP ligand (F8TPP=dianion of 5,10,15,20-tetrakis(2,6-difluorophenyl)porphine), an intermediate complex proposed as the hydrosulfide bridged dimer, (Bu4N)[Fe2(μ-SH)(F8TPP)2], was identified by NMR spectroscopy en route to formation of (Bu4N)[Fe(SH)(F8TPP)]...
August 27, 2016: Journal of Inorganic Biochemistry
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