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https://www.readbyqxmd.com/read/28535183/time-caloric-restriction-inhibits-the-neoplastic-transformation-of-cirrhotic-liver-in-rats-treated-with-diethylnitrosamine
#1
Christian Molina-Aguilar, María de Jesús Guerrero-Carrillo, Jesús Javier Espinosa-Aguirre, Sitlali Olguin-Reyes, Thania Castro-Belio, Olivia Vázquez-Martínez, Julieta Berenice Rivera-Zavala, Mauricio Díaz-Muñoz
Hepatocellular cancer is the most common type of primary liver cancer. Cirrhosis is the main risk factor that generates this malady. It has been proven that caloric restriction protocols and restricted feeding schedules are protective in experimental carcinogenic models. We tested the influence of a time-caloric restriction protocol (2 h of food access during the daytime for 18 weeks) in an experimental model of cirrhosis-hepatocarcinoma produced by weekly administration of diethylnitrosamine. Our results indicate that time-caloric restriction reduced hepatomegaly and prevented the increase in blood leukocytes promoted by diethylnitrosamine...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28532838/lactational-oestrus-and-reproductive-performance-following-a-delayed-limited-nursing-schedule-in-primiparous-sows
#2
REVIEW
T Y Chen, D L Turpin, A L Knight, E G Bouwman, N M Soede, R N Kirkwood, P Langendijk
With conventional lactation management, sows only conceive after weaning. However, intermittent suckling (IS) enables follicle growth and ovulation during lactation by reducing the suckling-induced inhibition of gonadotrophins. The current study evaluated IS regimes initiated at Day 21 or Day 28 post farrowing compared to conventional weaning on Day 28, in primiparous sows. Sows (Large White and Large White x Landrace) were randomly allocated to Control (C28; n = 44), IS21 (n = 29) and IS28 (n = 34) treatments at Day 20...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28525886/relationship-between-arterial-access-and-outcomes-in-st-elevation-myocardial-infarction-with-a-pharmacoinvasive-versus-primary-percutaneous-coronary-intervention-strategy-insights-from-the-strategic-reperfusion-early-after-myocardial-infarction-stream-study
#3
Jay Shavadia, Robert Welsh, Anthony Gershlick, Yinggan Zheng, Kurt Huber, Sigrun Halvorsen, Phillipe G Steg, Frans Van de Werf, Paul W Armstrong
BACKGROUND: The effectiveness of radial access (RA) in ST-elevation myocardial infarction (STEMI) has been predominantly established in primary percutaneous coronary intervention (pPCI) with limited exploration of this issue in the early postfibrinolytic patient. The purpose of this study was to compare the effectiveness and safety of RA versus femoral (FA) access in STEMI undergoing either a pharmacoinvasive (PI) strategy or pPCI. METHODS AND RESULTS: Within STrategic Reperfusion Early After Myocardial Infarction (STREAM), we evaluated the relationship between arterial access site and primary outcome (30-day composite of death, shock, congestive heart failure, or reinfarction) and major bleeding according to the treatment strategy received...
June 13, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28514964/help-problems-in-executing-a-pragmatic-randomized-stepped-wedge-trial-on-the-hospital-elder-life-program-to-prevent-delirium-in-older-patients
#4
Noor Heim, Henk F van Stel, Roelof G Ettema, Roos C van der Mast, Sharon K Inouye, Marieke J Schuurmans
BACKGROUND: A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on the experiences and lessons learned from the conduct of a cluster randomized, stepped wedge trial evaluating the effect of the Hospital Elder Life Program (HELP) in a Dutch hospital setting to prevent older patients from developing delirium. METHODS: We evaluated our trial which was conducted in eight departments in two hospitals in hospitalized patients aged 70 years or older who were at risk for delirium by reflecting on the assumptions that we had and on what we intended to accomplish when we started, as compared to what we actually realized in the different phases of our study...
May 17, 2017: Trials
https://www.readbyqxmd.com/read/28509811/implementation-of-a-new-method-to-track-propofol-in-an-endoscopy-unit
#5
Catherine Horvath
AIM: Propofol is a widely used anesthesia induction agent and is easily accessible in most healthcare facilities. Unlike regulated or schedule drugs, propofol is inconsistently tracked, leading to inaccurate inventories, incorrect billing, and unrecognized diversion. The goal of this project was to implement a new method of tracking propofol in a single setting, with the aim of accounting for 100% of the drug. METHODS: For two, 2-week observation periods, data were extracted from an automated medication management system or pharmacy inventory system, anesthesia records, and pharmacy billing sheets for cases in a Gastrointestinal (GI) Endoscopy Unit, and compared pre-implementation and post-implementation of a new tracking and accounting protocol...
April 29, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28508786/implementation-of-nationwide-electronic-health-record-in-albania-a-case-study
#6
Olegas Niaksu, Paulin Kodra, Mariola Pina, Johannes Grabenweger
BACKGROUND: This paper presents a case study of the nationwide implementation of an Electronic Health Record system based on industry standards. OBJECTIVES: To critically review the finalized nationwide EHR implementation in Albania, pointing out the achievements and the shortcomings, gained knowledge and sharing lessons learned. METHODS: This paper reports on our analysis of the project's documentation, first-hand experience working with healthcare professionals during and after project implementation...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28498615/understanding-the-impact-of-haemodialysis-on-uk-nhs-patients-wellbeing-a-qualitative-investigation
#7
Daniel J W Jones, Kate Harvey, John P Harris, Laurie T Butler, Emma C Vaux
AIMS AND OBJECTIVES: While haemodialysis (HD) is an effective treatment for end-stage renal disease (ESRD), the requirements and restrictions it imposes on patients can be onerous. The aim of the current study was to obtain UK National Health Service (NHS) patients' perspectives on the challenges arising from HD with the intention of identifying potential improvements. BACKGROUND: Depression rates are particularly high in those with ESRD, however, there is limited insight into the range of stressors associated with HD treatment within the NHS contributing to such high rates, particularly those of a cognitive or psychological nature...
May 12, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28495349/factors-that-impact-patient-web-portal-readiness-pwpr-among-the-underserved
#8
Priya Nambisan
OBJECTIVE: Healthcare organizations in the US are increasingly using Patient Portals as a means to provide patients with partial access to their health records and thereby comply with the 'meaningful use' of Health Information Technology policy issued by the US federal government. Patient portals are used to not only provide access to parts of the health records such as lab results but also offer services such as customized educational materials and appointment scheduling. While prior studies examining the adoption rates of these patient portals have not offered consistent findings, many of the studies have reported limited adoption and use [1] of patient portals, especially among the underserved population...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28493924/cognitive-function-in-multiple-sclerosis-improves-with-telerehabilitation-results-from-a-randomized-controlled-trial
#9
Leigh E Charvet, Jie Yang, Michael T Shaw, Kathleen Sherman, Lamia Haider, Jianjin Xu, Lauren B Krupp
Cognitive impairment affects more than half of all individuals living with multiple sclerosis (MS). We hypothesized that training at home with an adaptive online cognitive training program would have greater cognitive benefit than ordinary computer games in cognitively-impaired adults with MS. This was a double-blind, randomized, active-placebo-controlled trial. Participants with MS were recruited through Stony Brook Medicine and randomly assigned to either the adaptive cognitive remediation (ACR) program or active control of ordinary computer games for 60 hours over 12 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28492985/catheter-ablation-of-paroxysmal-atrial-fibrillation-circumferential-pulmonary-vein-ablation-success-rates-with-and-without-exclusion-of-areas-adjacent-to-the-esophagus
#10
Klaus Kettering, Dag-Hau Yim, Alexander Benz, Felix Gramley
BACKGROUND: Catheter ablation has become the first line of therapy in patients with symptomatic, recurrent, drug-refractory paroxysmal atrial fibrillation. Circumferential pulmonary vein ablation is still the standard approach in these patients. The occurrence of an atrioesophageal fistula is a rare but life-threatening complication after such ablation procedures. This is due to the fact that the esophagus does frequently have a very close anatomical relationship to the left or right pulmonary vein ostia...
May 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28489735/impact-of-a-preoperative-conversational-hypnotic-session-on-propofol-consumption-using-closed-loop-anesthetic-induction-guided-by-the-bispectral-index-a-randomized-controlled-trial
#11
Aurélien Bataille, Sébastien Besset, Barbara Szekely, Mireille Michel-Cherqui, Virginie Dumans, Ngai Liu, Thierry Chazot, Marc Fischler, Morgan Le Guen
OBJECTIVE: The automated administration of propofol in a closed loop could be used to objectively evaluate the nonpharmacological anesthetic action of hypnotherapy. The objective of this study was to evaluate the impact of a conversational hypnosis session on the consumption of propofol for anesthetic induction. DESIGN: A randomized, usual care-controlled, single-center, patient-blind trial. SETTING: Tertiary care center in France from November 2012 to December 2013...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489192/a-new-approach-to-feed-frequency-studies-and-protein-intake-regulation-in-juvenile-pirarucu
#12
Bruno O DE Mattos, Eduardo C T Nascimento, Aline A Santos, Kayck A Barreto, Francisco J Sánchez-Vázquez, Rodrigo Fortes-Silva
This study aimed to investigate pirarucu's (Arapaima gigas) ability to trigger a self-feeding system to regulate protein intake between two standard diets that contained 39% and 49% of crude protein. The same system allowed the evaluation of daily feeding and locomotor activity rhythms. Eighteen fish (654.44±26.85g) were distributed into six 250 L tanks (3 fish/tank). Fish had free access to both diets (39% vs. 49% protein) by feeders (2 per tank), adapted to be activated by fish themselves. This system was connected to a computer system...
April 27, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28482834/the-redistributive-effects-of-copayment-in-outpatient-prescriptions-evidence-from-lombardy
#13
Paolo Berta, Rosella Levaggi, Gianmaria Martini, Stefano Verzillo
BACKGROUND: In Italy, copayment has changed its nature and it can no longer be simply considered a system to curb inappropriate expenditure. It has become an important form of revenue for public health care provision, but it might also become a source of distortions in income and health benefits redistribution. METHODS: We use a rich administrative dataset gathering information on patients demand (whose records have been matched to income declared for tax purposes) to study the effects of an additional copayment (the so called "superticket" introduced by the Italian government in 2012) in Lombardy, the biggest Italian Region whose socio-economic dimension is comparable to that of many European countries (e...
May 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28481752/preoperative-cognitive-performance-and-postoperative-delirium-are-independently-associated-with-future-dementia-in-older-people-who-have-undergone-cardiac-surgery-a-longitudinal-cohort-study
#14
Helena Claesson Lingehall, Nina S Smulter, Elisabeth Lindahl, Marie Lindkvist, Karl Gunnar Engström, Yngve G Gustafson, Birgitta Olofsson
OBJECTIVE: To investigate if postoperative delirium was associated with the development of dementia within 5 years after cardiac surgery. DESIGN: Longitudinal cohort study. SETTING: Cardiothoracic Division, Umeå University Hospital, Sweden. PATIENTS: Patients aged 70 years old or older (n = 114) scheduled for routine cardiac procedures with cardiopulmonary bypass without documented dementia were enrolled in 2009. INTERVENTION: Structured assessments were performed preoperatively, 1 and 4 days after extubation, and 1, 3, and 5 years postoperatively...
May 5, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28479443/post-operative-pain-management-following-thoracic-outlet-decompression
#15
Mathew Wooster, Dana Reed, Adam Tanious, Karl Illig
BACKGROUND: Thoracic outlet decompression (TOD) is associated with significant post operative pain often leading to hospital length of stay out of proportion to the risk profile of the operation. We seek to describe the improvement in hospital length of stay and patient pain control with an improved multi-agent pain management regimen. METHODS: We retrospectively reviewed the hospital length of stay, medication regimen/usage, operative details, and operative indications for all patients undergoing TOD from January 2012 through June 2015...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28474972/reaching-rural-ohio-with-intellectual-disability-psychiatry
#16
Julie P Gentile, Allison E Cowan, Beth Harper, Ryan Mast, Brian Merrill
Individuals with intellectual disability experience higher rates of mental illness when compared with the general population, and there is a lack of medical and mental health professionals in rural and under-served areas. With the increase in discharge of individuals from institutional settings back to their home communities into the least restrictive environments, there are more patients with complex needs being added to the schedules of physicians in the outpatient delivery care system. Patients with disabilities may not travel well or tolerate changes in routine so may not have access to psychiatry...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28472027/surveillance-of-vaccination-coverage-among-adult-populations-united-states-2015
#17
Walter W Williams, Peng-Jun Lu, Alissa O'Halloran, David K Kim, Lisa A Grohskopf, Tamara Pilishvili, Tami H Skoff, Noele P Nelson, Rafael Harpaz, Lauri E Markowitz, Alfonso Rodriguez-Lainz, Amy Parker Fiebelkorn
PROBLEM/CONDITION: Overall, the prevalence of illness attributable to vaccine-preventable diseases is greater among adults than among children. Adults are recommended to receive vaccinations based on their age, underlying medical conditions, lifestyle, prior vaccinations, and other considerations. Updated vaccination recommendations from CDC are published annually in the U.S. Adult Immunization Schedule. Despite longstanding recommendations for use of many vaccines, vaccination coverage among U...
May 5, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28471436/a-novel-approach-in-pediatric-telegenetic-services-geneticist-pediatrician-and-genetic-counselor-team
#18
Shobana Kubendran, Siddharthan Sivamurthy, Gerald Bradley Schaefer
PurposeOur aim was to improve access to genetic services in an underserved region by developing a collaborative telegenetic service delivery model with a pediatrician, medical geneticist, and genetics counselor (GC).MethodsProtocols for the evaluation of common genetic indications were developed. Patients referred with indications suggestive of a syndromic etiology were scheduled to see the geneticist directly via telegenetics. Other patients were scheduled to see the pediatrician and GC in person before follow-up with the geneticist if indicated...
May 4, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28463931/multiparametric-magnetic-resonance-imaging-of-the-prostate-repeatability-of-volume-and-apparent-diffusion-coefficient-quantification
#19
Andriy Fedorov, Mark G Vangel, Clare M Tempany, Fiona M Fennessy
OBJECTIVES: The aim of this study was to evaluate the repeatability of a region of interest (ROI) volume and mean apparent diffusion coefficient (ADC) in standard-of-care 3 T multiparametric magnetic resonance imaging (mpMRI) of the prostate obtained with the use of endorectal coil. MATERIALS AND METHODS: This prospective study was Health Insurance Portability and Accountability Act compliant, with institutional review board approval and written informed consent...
May 1, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28463442/understanding-perceptions-of-school-administrators-related-to-school-breakfast-in-a-low-school-breakfast-participation-state
#20
Natoshia M Askelson, Elizabeth H Golembiewski, Ann Bobst, Patti J Delger, Carrie A Scheidel
BACKGROUND: The National School Breakfast Program (SBP) is a federally funded program that allows states to offer nutritious breakfast to K-12 students. However, rates of SBP participation are low in some rural states, and the reasons are not well understood. The purpose of the study was to explore administrators' perceptions, attitudes, and beliefs related to the SBP, and factors they identify as barriers or facilitators to increased participation. METHODS: Data were collected from a cross-sectional, online survey of K-12 school administrators (N = 152) in a rural, midsized Midwestern state fielded over an academic year...
June 2017: Journal of School Health
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