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https://www.readbyqxmd.com/read/29789277/applicability-of-a-web-based-individualized-exercise-intervention-in-patients-with-liver-disease-cystic-fibrosis-esophageal-cancer-and-psychiatric-disorders-process-evaluation-of-4-ongoing-clinical-trials
#1
Daniel Pfirrmann, Nils Haller, Yvonne Huber, Patrick Jung, Klaus Lieb, Ines Gockel, Krystyna Poplawska, Jörn Markus Schattenberg, Perikles Simon
BACKGROUND: In the primary and secondary prevention of civilization diseases, regular physical activity is recommended in international guidelines to improve disease-related symptoms, delay the progression of the disease, or to enhance postoperative outcomes. In the preoperative context, there has been a paradigm shift in favor of using preconditioning concepts before surgery. Web-based interventions seem an innovative and effective tool for delivering general information, individualized exercise recommendations, and peer support...
May 22, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29789100/healthcare-resource-utilisation-by-patients-with-coronary-heart-disease-receiving-a-lifestyle-focused-text-message-support-program-an-analysis-from-the-text-me-study
#2
Jay Thakkar, Julie Redfern, Ehsan Khan, Emily Atkins, Jeffrey Ha, Kha Vo, Aravinda Thiagalingam, Clara K Chow
The 'Tobacco, Exercise and Diet Messages' (TEXT ME) study was a 6-month, single-centre randomised clinical trial (RCT) that found a text message support program improved levels of cardiovascular risk factors in patients with coronary heart disease (CHD). The current analyses examined whether receipt of text messages influenced participants' engagement with conventional healthcare resources. The TEXT ME study database (N=710) was linked with routinely collected health department databases. Number of doctor consultations, investigations and cardiac medication prescriptions in the two study groups were compared...
May 23, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29784798/stabilized-single-injection-inactivated-polio-vaccine-elicits-a-strong-neutralizing-immune-response
#3
Stephany Y Tzeng, Kevin J McHugh, Adam M Behrens, Sviatlana Rose, James L Sugarman, Shiran Ferber, Robert Langer, Ana Jaklenec
Vaccination in the developing world is hampered by limited patient access, which prevents individuals from receiving the multiple injections necessary for protective immunity. Here, we developed an injectable microparticle formulation of the inactivated polio vaccine (IPV) that releases multiple pulses of stable antigen over time. To accomplish this, we established an IPV stabilization strategy using cationic polymers for pH modulation to enhance traditional small-molecule-based stabilization methods. We investigated the mechanism of this strategy and showed that it was broadly applicable to all three antigens in IPV...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29777289/tobacco-smoking-may-delay-habituation-of-reinforcer-effectiveness-in-humans
#4
Joshua L Karelitz, Kenneth A Perkins
BACKGROUND: The effectiveness of nonconsummatory reinforcers habituate, as their ability to maintain reinforced responding declines over repeated presentations. Preclinical research has shown that nicotine can delay habituation of reinforcer effectiveness, but this effect has not been directly demonstrated in humans. OBJECTIVE: In preliminary translational research, we assessed effects of nicotine from tobacco smoking (vs. a no smoking control) on within-session patterns of responding for a brief visual reinforcer...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29776898/implementing-internet-based-self-care-programs-in-primary-care-qualitative-analysis-of-determinants-of-practice-for-patients-and-providers
#5
Eric Hermes, Laura Burrone, Elliottnell Perez, Steve Martino, Michael Rowe
BACKGROUND: Access to evidence-based interventions for common mental health conditions is limited due to geographic distance, scheduling, stigma, and provider availability. Internet-based self-care programs may mitigate these barriers. However, little is known about internet-based self-care program implementation in US health care systems. OBJECTIVE: The objective of this study was to identify determinants of practice for internet-based self-care program use in primary care by eliciting provider and administrator perspectives on internet-based self-care program implementation...
May 18, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29764639/web-based-versus-face-to-face-interprofessional-team-encounters-with-standardized-patients
#6
Kelly A Lempicki, Christine S Holland
BACKGROUND: Challenges exist in developing interprofessional education (IPE) activities including coordinating schedules and obtaining appropriate space for teams to work. Virtual worlds have been explored as a means to overcome some of these challenges. We sought to develop a web-based interprofessional team interaction with a standardized patient (SP), as compared to a face-to-face SP interaction, focusing on the competency area of interprofessional communication. INTERPROFESSIONAL EDUCATION ACTIVITY: Interprofessional teams of students were randomized to complete a web-based or face-to-face SP encounter...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29762792/medical-student-interest-in-flexible-residency-training-options
#7
Madison Piotrowski, Debra Stulberg, Mari Egan
BACKGROUND AND OBJECTIVES: Medical residents continue to experience high rates of burnout during residency training even after implementation of the 2003 Accreditation Council for Graduate Medical Education duty-hour restrictions. The purpose of this study is to determine medical student interest in flexible residency training options. METHODS: Researchers developed an 11-question survey for second through fourth-year medical students. The populations surveyed included medical students who were: (1) attending the 2015 American Academy of Family Physicians National Conference, the 2015 Family Medicine Midwest Conference, and (2) enrolled at University of Chicago Pritzker School of Medicine, University of Illinois College of Medicine at Chicago, Drexel University College of Medicine, and Case Western Reserve University School of Medicine...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29762723/pyabc-distributed-likelihood-free-inference
#8
Emmanuel Klinger, Dennis Rickert, Jan Hasenauer
Summary: Likelihood-free methods are often required for inference in systems biology. While Approximate Bayesian Computation (ABC) provides a theoretical solution, its practical application has often been challenging due to its high computational demands. To scale likelihood-free inference to computationally demanding stochastic models we developed pyABC: a distributed and scalable ABC-Sequential Monte Carlo (ABC-SMC) framework. It implements a scalable, runtime-minimizing parallelization strategy for multi-core and distributed environments scaling to thousands of cores...
May 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29762506/optimal-resource-allocation-for-noma-tdma-scheme-with-%C3%AE-fairness-in-industrial-internet-of-things
#9
Yanjing Sun, Yiyu Guo, Song Li, Dapeng Wu, Bin Wang
In this paper, a joint non-orthogonal multiple access and time division multiple access (NOMA-TDMA) scheme is proposed in Industrial Internet of Things (IIoT), which allowed multiple sensors to transmit in the same time-frequency resource block using NOMA. The user scheduling, time slot allocation, and power control are jointly optimized in order to maximize the system α -fair utility under transmit power constraint and minimum rate constraint. The optimization problem is nonconvex because of the fractional objective function and the nonconvex constraints...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29754452/part-1-current-prescribing-trends-of-antibiotics-by-dentists-in-australia-from-2013-to-2016
#10
L Teoh, K Stewart, R J Marino, M J McCullough
BACKGROUND: Literature has shown dentists tend to overprescribe antibiotics and do not always prescribe in accordance with recommended guidelines. Unnecessary prescribing is one major factor that contributes to the development of antibiotic resistance. The aim of the present study was to assess the antibacterial prescribing patterns of dentists in Australia from 2013 to 2016. METHODS: Data on dental antibacterial prescriptions dispensed under the Pharmaceutical Benefits Scheme (PBS) from 2013 to 2016 was accessed and prescribing trends analysed...
May 13, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29751690/cellular-v2x-communications-for-platooning-design-and-evaluation
#11
Giovanni Nardini, Antonio Virdis, Claudia Campolo, Antonella Molinaro, Giovanni Stea
Platooning is a cooperative driving application where autonomous/semi-autonomous vehicles move on the same lane in a train-like manner, keeping a small constant inter-vehicle distance, in order to reduce fuel consumption and gas emissions and to achieve safe and efficient transport. To this aim, they may exploit multiple on-board sensors (e.g., radars, LiDARs, positioning systems) and direct vehicle-to-vehicle communications to synchronize their manoeuvres. The main objective of this paper is to discuss the design choices and factors that determine the performance of a platooning application, when exploiting the emerging cellular vehicle-to-everything (C-V2X) communication technology and considering the scheduled mode, specified by 3GPP for communications over the sidelink assisted by the eNodeB...
May 11, 2018: Sensors
https://www.readbyqxmd.com/read/29747862/the-effect-of-insurance-type-on-access-to-inguinal-hernia-repair-under-the-affordable-care-act
#12
Walter Hsiang, Catherine McGeoch, Sarah Lee, William Cheung, Robert Becher, Kimberly A Davis, Kevin M Schuster
BACKGROUND: The expansion of Medicaid under the Affordable Care Act extended coverage to any individual with an income up to 138% of the federal poverty level. Our study of surgeon practice management investigated the impact of the type of insurance on access to elective inguinal hernia repair and the disparities in access between Medicaid expansion and nonexpansion states. METHODS: Practices of 240 hernia repair surgeons across 8 states were randomly selected from the American College of Surgeons Find a Surgeon Database...
May 7, 2018: Surgery
https://www.readbyqxmd.com/read/29741643/pannzer2-a-rapid-functional-annotation-web-server
#13
Petri Törönen, Alan Medlar, Liisa Holm
The unprecedented growth of high-throughput sequencing has led to an ever-widening annotation gap in protein databases. While computational prediction methods are available to make up the shortfall, a majority of public web servers are hindered by practical limitations and poor performance. Here, we introduce PANNZER2 (Protein ANNotation with Z-scoRE), a fast functional annotation web server that provides both Gene Ontology (GO) annotations and free text description predictions. PANNZER2 uses SANSparallel to perform high-performance homology searches, making bulk annotation based on sequence similarity practical...
May 8, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29738795/animal-models-of-binge-drinking-current-challenges-to-improve-face-validity
#14
REVIEW
Jérôme Jeanblanc, Benjamin Rolland, Fabien Gierski, Margaret P Martinetti, Mickael Naassila
Binge drinking (BD), i.e., consuming a large amount of alcohol in a short period of time, is an increasing public health issue. Though no clear definition has been adopted worldwide the speed of drinking seems to be a keystone of this behavior. Developing relevant animal models of BD is a priority for gaining a better characterization of the neurobiological and psychobiological mechanisms underlying this dangerous and harmful behavior. Until recently, preclinical research on BD has been conducted mostly using forced administration of alcohol, but more recent studies used scheduled access to alcohol, to model more voluntary excessive intakes, and to achieve signs of intoxications that mimic the human behavior...
May 5, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29732483/feasibility-and-accessibility-of-electronic-patient-reported-outcome-measures-using-a-smartphone-during-routine-chemotherapy-a-pilot-study
#15
Woo Kyun Bae, Jihyun Kwon, Hyun Woo Lee, Sang-Cheol Lee, Eun-Kee Song, Hyeok Shim, Keun Ho Ryu, Jemin Song, Sungbo Seo, Yaewon Yang, Jong-Hyock Park, Ki Hyeong Lee, Hye Sook Han
PURPOSE: There is growing interest in integrating electronic patient-reported outcome (PRO) measures into routine oncology practice for symptom monitoring. Here, we evaluated the feasibility and accessibility of electronic PRO measures using a smartphone (PRO-SMART) for cancer patients receiving routine chemotherapy. METHODS: The proposed PRO-SMART application obtains daily personal health record (PHR) data from cancer patients via a smartphone. An analysis report of cumulative PHR data is provided to the clinician in a format suitable for upload to electronic medical records (EMRs)...
May 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29730798/effects-of-an-infratrochlear-nerve-block-on-reducing-the-oculocardiac-reflex-during-strabismus-surgery-a-randomized-controlled-trial
#16
Seung-Hyun Kim, Hyun Jin Shin
PURPOSE: To determine whether an infratrochlear nerve block (ITB) can reduce the oculocardiac reflex (OCR) during strabismus surgery on the medial rectus muscle (MR). METHODS: This prospective, randomized single-masked study included 60 patients with intermittent exotropia scheduled for unilateral MR resection/lateral rectus recession under general anesthesia. Patients were randomly allocated to receive a regional nerve block of the infratrochlear nerve (ITB group) prior to surgery or standard treatment without a nerve block (control group)...
May 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29720302/assessing-pneumococcal-vaccination-availability-in-under-vaccinated-rural-counties-a-pharmacy-perspective
#17
Karen Colorafi, Shannon Panther, Kimberly McKeirnan, Daryl Potyk, John McCarthy, Sarah Temple
OBJECTIVE: Vaccines are a low-cost, high-impact interventions that effectively and efficiently reduce the burden of infectious diseases. Many rural populations have vaccination rates well below nationally recommended levels. Community pharmacies may offer a solution to this problem. Under a collaborative drug therapy agreement (CDTA), pharmacists can prescribe and administer immunizations. The purpose of this study was to examine pneumococcal vaccine access in rural pharmacies in Eastern Washington state...
March 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29720138/a-formative-study-to-understand-perspectives-of-families-eligible-for-a-pediatric-obesity-program-a-qualitative-study
#18
Rachel G Tabak, Nishita Dsouza, Cynthia D Schwarz, Karyn Quinn, Patricia Kristen, Debra Haire-Joshu
BACKGROUND: Raising Well® (RW) was initiated in 2015 by Envolve PeopleCare™ at the request of health plans seeking a solution to work with families on Medicaid that have a child with overweight or obesity. RW uses expert clinical coaches via phone contact to deliver an educational intervention promoting lifestyle change to families with at least one overweight or obese child in an eligible Medicaid health plan. This gives RW significant potential for reach and population impact. This project aimed to understand how to maximize this impact by exploring perspectives of RW, using a conceptual framework informed by the Conceptual Model of Implementation Research, including assessment of the feasibility, acceptability, and appropriateness of RW; determining satisfaction among those experiencing coaching; identifying reasons individuals do not participate; and developing recommendations to enhance interest and participation...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29717677/facilitating-earlier-diagnosis-of-cardiovascular-disease-through-point-of-care-biosensors-a-review
#19
Mackenzie M Honikel, Chi-En Lin, David Probst, Jeffrey T La Belle
Cardiovascular disease (CVD) accounts for 30% of all global deaths and is predicted to dominate in the coming years, despite vast improvements in medical technology. Current clinical methods of assessing an individual's cardiovascular health include blood tests to monitor relevant biomarker levels as well as varying imaging modalities such as electrocardiograms, computed tomography, and angiograms to assess vasculature. As informative as these tools are, they each require lengthy scheduling, preparation, and highly trained personnel to interpret the results before any information is accessible to patients, often leading to delayed treatment, which can be fatal...
2018: Critical Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/29716586/access-to-health-care-for-uninsured-latina-immigrants-in-south-carolina
#20
John S Luque, Grace Soulen, Caroline B Davila, Kathleen Cartmell
BACKGROUND: South Carolina is considered a "new destination" state for Latino immigrants. Language barriers, transportation difficulties, low socioeconomic status, inflexible work schedules, different cultural norms, and anxiety and fear related to the current anti-immigrant political climate all negatively impact Latino immigrants' frequency of contact with the health care system, and consequently they suffer poor health outcomes. The study objective was to explore uninsured Latina immigrant women's access to health care and alternative treatment strategies in coastal South Carolina...
May 2, 2018: BMC Health Services Research
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