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https://www.readbyqxmd.com/read/28637307/sparing-carbapenem-usage
#1
A Peter R Wilson
Background: Carbapenem resistance in Gram-negative bacteria is increasing in many countries and use of carbapenems and antibiotics to which resistance is linked should be reduced to slow its emergence. There are no directly equivalent antibiotics and the alternatives are less well supported by clinical trials. The few new agents are expensive. Objectives: To provide guidance on strategies to reduce carbapenem usage. Methods: A literature review was performed as described in the BSAC/HIS/BIA/IPS Joint Working Party on Multiresistant Gram-negative Infection Report...
June 15, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28520867/activity-of-ceftolozane-tazobactam-against-surveillance-and-problem-enterobacteriaceae-pseudomonas-aeruginosa-and-non-fermenters-from-the-british-isles
#2
David M Livermore, Shazad Mushtaq, Daniele Meunier, Katie L Hopkins, Robert Hill, Rachael Adkin, Aiysha Chaudhry, Rachel Pike, Peter Staves, Neil Woodford
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against 'problem' isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28124956/-investigation-of-the-frequency-and-distribution-of-beta-lactamase-genes-in-the-clinical-isolates-of-acinetobacter-baumannii-collected-from-different-regions-of-turkey-a-multicenter-study
#3
Fatih Şaban Beriş, Emine Esra Budak, Duygu Gülek, Aytül Uzun, Zeynep Çizmeci, Fırat Zafer Mengeloğlu, Şahin Direkel, Yeliz Çetinkol, Yasemin Ay Altıntop, Meryem Iraz, Tuba Dal, Safiye Umut Say Coşkun, Pervin Özlem Balcı, Tuba Kayman, Ahmet Çalışkan, Yelda Yazıcı, İsmail Tosun, Ayşe Ertürk, Ayşegül Çopur Çiçek
The diversity and distribution of TEM, SHV and CTX-M type of extended-spectrum beta-lactamases (ESBLs) are important for the treatment and control of infections. Determination of ESBL genes in clinical isolates by polymerase chain reaction (PCR) and DNA sequencing can obtain useful data for their molecular epidemiology and risk. The aim of this study was to investigate the frequency of beta-lactamase genes in Acinetobacter baumannii strains isolated from different regions of Turkey. A total of 519 A.baumannii strains collected from hospitals located at 12 different provinces of Turkey (Bolu (n= 67), Tokat (n= 47), Trabzon (n= 25), Ordu (n= 27), Diyarbakır (n= 47), Niğde (n=31), Kayseri (n= 36), Ankara (n= 41), Kirikkale (n= 26), Kahramanmaraş (n= 25), Mersin (n= 40), Istanbul (n= 107)] between 2011-2012 period were included in the study...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28073969/characterization-of-carbapenemase-producing-enterobacteriaceae-in-the-west-midlands-region-of-england-2007-14
#4
Jacqueline Findlay, Katie L Hopkins, Adela Alvarez-Buylla, Daniéle Meunier, Nazim Mustafa, Robert Hill, Rachel Pike, Li-Xu McCrae, Peter M Hawkey, Neil Woodford
Objectives: Carbapenemase-producing Enterobacteriaceae (CPE) have been increasingly reported in the UK since 2003. We analysed patient and isolate data for CPE confirmed by the national reference laboratory from laboratories in the West Midlands region from November 2007 to December 2014. Methods: MICs were determined by BSAC agar dilution methodology and isolates exhibiting resistance to one or more carbapenems were screened for carbapenemase genes by PCR. Plasmid analyses were performed after electro-transformation of carbapenemase-encoding plasmids...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28073966/extended-stability-of-antimicrobial-agents-in-administration-devices
#5
Abi Jenkins, Tim Hills, Mark Santillo, Mark Gilchrist
Background: Outpatient parenteral antimicrobial therapy (OPAT) is an established approach to patient care. A lack of data on antimicrobial stability within administration devices is a barrier to service expansion, and poses an antimicrobial stewardship dilemma. Often broad-spectrum, long half-life agents are used instead of narrow-spectrum agents, which need more frequent administration, but could possibly be used if stability data were available. Objectives: To complete a comprehensive literature review of published antimicrobial stability data, and assess these against a nationally recognized minimum dataset for medicines compounded into administration devices...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28006650/rise-of-multidrug-resistant-non-vaccine-serotype-15a-streptococcus-pneumoniae-in-the-united-kingdom-2001-to-2014
#6
Carmen Sheppard, Norman K Fry, Shazad Mushtaq, Neil Woodford, Rosy Reynolds, Regina Janes, Rachel Pike, Robert Hill, Maimuna Kimuli, Peter Staves, Michel Doumith, Timothy Harrison, David M Livermore
Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001-2014; (ii) Public Health England's (PHE) invasive isolate surveillance from 2005-2014 and (iii) referral to PHE for resistance investigation from 2005-2014. Serotype 15A increased in all series, with many representatives showing triple resistance to macrolides, tetracyclines and penicillin...
December 15, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27999053/issues-in-antifungal-stewardship-an-opportunity-that-should-not-be-lost
#7
Chand Wattal, Arunaloke Chakrabarti, Jaswinder Kaur Oberoi, J Peter Donnelly, Rosemary A Barnes, B L Sherwal, Neeraj Goel, Sonal Saxena, George M Varghese, Rajeev Soman, Poonam Loomba, Bansidhar Tarai, Sanjay Singhal, Naimish Mehta, V Ramasubramanian, Dharma Choudhary, Yatin Mehta, Supradip Ghosh, Sumathi Muralidhar, Ravinder Kaur
Many countries have observed an increase in the incidence of invasive fungal infections (IFIs) over the past two decades with emergence of new risk factors and isolation of new fungal pathogens. Early diagnosis and appropriate antifungal treatment remain the cornerstones of successful outcomes. However, due to non-specific clinical presentations and limited availability of rapid diagnostic tests, in more than half of cases antifungal treatment is inappropriate. As a result, the emergence of antifungal resistance both in yeasts and mycelial fungi is becoming increasingly common...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27724873/antimicrobial-susceptibility-testing-of-neisseria-gonorrhoeae-isolates-in-pakistan-by-etest-compared-to-calibrated-dichotomous-sensitivity-and-clinical-laboratory-standards-institute-disc-diffusion-techniques
#8
COMPARATIVE STUDY
Pushpa Bhawan Mal, Kauser Jabeen, Joveria Farooqi, Magnus Unemo, Erum Khan
BACKGROUND: Accurate detection of Neisseria gonorrhoeae antimicrobial resistance is essential for appropriate management and prevention of spread of infection in the community. In this study Calibrated Dichotomous Sensitivity (CDS) and Clinical Laboratory Standards Institute (CLSI) disc diffusion methods were compared with minimum inhibitory concentration (MIC) by Etest in Neisseria gonorrhoeae isolates from Karachi, Pakistan. CDS and CLSI disc diffusion techniques, and Etest for ceftriaxone, penicillin G, spectinomycin and ciprofloxacin against 100 isolates from years 2012-2014 were performed...
October 10, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27530859/multidrug-resistant-staphylococcus-haemolyticus-isolates-from-infected-eyes-and-healthy-conjunctivae-in-india
#9
Sasmita Panda, Sarita Kar, Savitri Sharma, Durg V Singh
This study aimed to determine the presence of antibiotic resistance genes (ARGs), SCCmec elements and genetic relatedness among Staphylococcus haemolyticus isolated from patients with a variety of eye infections (n=11) and from healthy conjunctiva (n=7). Minimum inhibitory concentrations were determined for 14 antimicrobials according to BSAC guidelines. PCR was used to identify the presence of mecA, mecC, SCCmec type and ARGs. Sequencing was used to determine mutations in gyrA, gyrB, topoisomerase IVA and IVB genes...
September 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27530786/-prevalence-of-moraxella-catarrhalis-in-the-nasopharyngeal-specimen-from-1%C3%A2-082-hospitalized-children-with-respiratory-infection-and-the-drug-resistance-of-the-isolates
#10
Ping Tang, Wei Shi, Hai-Ling Zeng, Wei Ding, Cheng Wang, Kai-Hu Yao, De-Nian Wen
OBJECTIVE: To investigate the prevalence of Moraxella catarrhalis in the nasopharyngeal region of children with respiratory infection and the sensitivity of Moraxella catarrhalis isolates to common antimicrobial drugs. METHODS: Nasopharyngeal swabs were collected from 1 082 children with respiratory infection, and Moraxella catarrhalis strains were isolated. The E-test method and disc diffusion test were used to determine the sensitivity of these strains to 11 common antimicrobial drugs...
August 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27494904/amikacin-use-and-therapeutic-drug-monitoring-in-adults-do-dose-regimens-and-drug-exposures-affect-either-outcome-or-adverse-events-a-systematic-review
#11
REVIEW
Abi Jenkins, Alison H Thomson, Nicholas M Brown, Yvonne Semple, Christine Sluman, Alasdair MacGowan, Andrew M Lovering, Phil J Wiffen
OBJECTIVES: The objectives of this study were to identify the amikacin dosage regimens and drug concentrations consistent with good outcomes and to determine the drug exposures related to nephrotoxicity and ototoxicity. METHODS: A literature review was conducted in Medline, EMBASE and the Cochrane Central Register of Controlled Trials. Full journal articles reporting randomized controlled trials, controlled clinical trials, interrupted time series trials, and controlled before and after studies involving amikacin therapeutic drug monitoring (TDM) and dose adjustment were considered for inclusion...
October 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27180331/behind-the-scenes-of-jac-the-british-society-for-antimicrobial-chemotherapy
#12
REVIEW
Tracey Guise, Dilip Nathwani
This brief article describes the relationship between the British Society for Antimicrobial Chemotherapy (BSAC) and JAC, and how JAC has directly and indirectly facilitated delivery of the BSAC's charitable objectives over the past 40 years.
2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27150395/population-structure-of-escherichia-coli-causing-bacteraemia-in-the-uk-and-ireland-between-2001-and-2010
#13
M J Day, M Doumith, J Abernethy, R Hope, R Reynolds, J Wain, D M Livermore, N Woodford
OBJECTIVES: Escherichia coli is the most common agent of bacteraemia, bacterial gastroenteritis and urinary tract infections (UTIs). Lineages causing UTIs and gastrointestinal disease are well defined, but less is known about those causing bacteraemia. We therefore investigated the population structure of E. coli from bacteraemia in the UK and Ireland between 2001 and 2010. METHODS: E. coli isolates (n = 2166) were submitted to the BSAC Bacteraemia Surveillance Programme from 18 UK and Irish centres from 2001 to 2010...
August 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26945714/inactivation-or-inhibition-of-acrab-tolc-increases-resistance-of-carbapenemase-producing-enterobacteriaceae-to-carbapenems
#14
Howard T H Saw, Mark A Webber, Shazad Mushtaq, Neil Woodford, Laura J V Piddock
OBJECTIVES: The objective of this study was to study the contribution of the multidrug resistance AcrAB-TolC efflux system to carbapenem resistance in carbapenemase-producing Enterobacteriaceae and the impact of the efflux inhibitor PABN on this resistance. METHODS: Klebsiella pneumoniae, Escherichia coli, Salmonella enterica serovar Typhimurium and their corresponding AcrAB-TolC mutants, each carrying carbapenemase-carrying plasmids (pKpQIL-UK with blaKPC and pNDM-HK with blaNDM), were tested for their susceptibility to six β-lactam antibiotics according to the BSAC agar dilution method...
June 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26846210/kpc-enzymes-in-the-uk-an-analysis-of-the-first-160-cases-outside-the-north-west-region
#15
Jacqueline Findlay, Katie L Hopkins, Michel Doumith, Danièle Meunier, Camilla Wiuff, Robert Hill, Rachel Pike, Richard Loy, Nazim Mustafa, David M Livermore, Neil Woodford
OBJECTIVES: Klebsiella pneumoniae carbapenemases (KPCs) have been increasingly reported in the UK since 2003. We analysed patient and isolate data for KPC-positive bacteria confirmed by the national reference laboratory from UK laboratories from August 2003 to August 2014, excluding North-West England, where the epidemiology has previously been studied. METHODS: MICs were determined by BSAC agar dilution. Carbapenem-resistant isolates lacking imipenem/EDTA synergy were tested by PCR for blaKPC...
May 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26821389/the-world-as-it-is-british-sub-aqua-club-bsac-diving-incidents-report-2014
#16
Brian Cummings
No abstract text is available yet for this article.
December 2015: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/26816891/non-diphtheritic-corynebacteria-an-emerging-nosocomial-pathogen-in-skin-and-soft-tissue-infection
#17
Shoorashetty Manohar Rudresh, G S Ravi, Ann Mary Alex, K R Mamatha, L Sunitha, K Thangam Ramya
INTRODUCTION: Non-diphtheritic corynebacteria are normal inhabitants of skin and mucous membrane. When isolated from clinical specimens they are often considered as contaminants. Recent reports suggest their role as emerging nosocomial pathogens. AIM: To speciate non-diphtheritic corynebacteria isolated from wound specimens, to correlate their clinical significance and to determine their invitro antimicrobial susceptibilities to 9 antimicrobial agents. MATERIALS AND METHODS: Twenty five non-diphtheritic corynebacteria from skin and soft tissue infections were selected for study...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26377864/antimicrobial-susceptibility-testing-breakpoints-and-methods-from-bsac-to-eucast
#18
REVIEW
Derek F J Brown, Mandy Wootton, Robin A Howe
The BSAC Standing Committee on Antimicrobial Susceptibility Testing is one of several European national breakpoint committees that agreed in 2002 to harmonize clinical MIC breakpoints. The process of harmonization has since been completed for commonly used agents, and breakpoints for new agents have been set by EUCAST in accordance with a procedure defined by the EMA. EUCAST breakpoints have now been adopted by a large majority of laboratories in Europe. BSAC implemented the EUCAST breakpoints in its own disc diffusion susceptibility testing method as harmonized breakpoints were agreed to over the years...
January 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26320614/identification-of-genetic-variation-exclusive-to-specific-lineages-associated-with-staphylococcus-aureus-bacteraemia
#19
D Patel, M J Ellington, R Hope, R Reynolds, C Arnold, M Desai
BACKGROUND: Meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia cases have declined since 2003, and have mostly been due to two epidemic (E) strains, E15 (multi-locus sequence type clonal complex CC22) and E16 (CC30). By contrast, the incidence of meticillin-susceptible S. aureus (MSSA) bacteraemia has remained largely unchanged and our understanding of these isolates has remained poor. AIM: To investigate the distribution and nucleotide sequence of heterogeneous regions between successful lineages using the 2009 British Society for Antimicrobial Chemotherapy (BSAC) Bacteraemia Resistance Surveillance Programme collection of S...
October 2015: Journal of Hospital Infection
https://www.readbyqxmd.com/read/26318188/susceptibility-testing-challenges-with-ceftaroline-mrsa-and-a-1-mg-l-breakpoint
#20
MULTICENTER STUDY
David M Livermore, Shazad Mushtaq, Marina Warner, Dorothy James, Neil Woodford
OBJECTIVES: A 1 mg/L susceptibility breakpoint for ceftaroline and staphylococci is universally agreed; EUCAST counts MIC >1 mg/L as resistant whereas CLSI and FDA count 2 mg/L as intermediate and >2 mg/L as resistant. We investigated whether routine diagnostic tests reliably distinguish MICs of 1 versus 2 mg/L. METHODS: Thirty-five UK laboratories collected Staphylococcus aureus isolates and performed tests with 5 μg (as EUCAST) or 30 μg (as CLSI) discs and either confluent growth on Mueller-Hinton agar (as EUCAST and CLSI) or semi-confluent growth on Iso-Sensitest agar (as BSAC)...
December 2015: Journal of Antimicrobial Chemotherapy
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