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Kristina H Haugaa

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https://www.readbyqxmd.com/read/28326674/whole-exome-sequencing-with-genomic-triangulation-implicates-cdh2-encoded-n-cadherin-as-a-novel-pathogenic-substrate-for-arrhythmogenic-cardiomyopathy
#1
Kari L Turkowski, David J Tester, J Martijn Bos, Kristina H Haugaa, Michael J Ackerman
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a heritable disease characterized by fibrofatty replacement of cardiomyocytes, has a prevalence of approximately 1 in 5000 individuals, and accounts for approximately 20% of sudden cardiac death in the young (≤35 years). ACM is most often inherited as an autosomal dominant trait with incomplete penetrance and variable expression. While mutations in several genes that encode key desmosomal proteins underlie about half of all ACM, the remainder is elusive genetically...
March 21, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28274572/comparison-of-electrocardiography-markers-and-speckle-tracking-echocardiography-for-assessment-of-left-ventricular-myocardial-scar-burden-in-patients-with-previous-myocardial-infarction
#2
Eirik Nestaas, Jhih-Yuan Shih, Marit K Smedsrud, Ola Gjesdal, Einar Hopp, Kristina H Haugaa, Thor Edvardsen
Myocardial scar burden is an important prognostic factor after myocardial infarction. This cohort study compared assessment of left ventricle scar burden between pathological Q waves on electrocardiography (ECG), Selvester multiparametric ECG scoring system for scar burden, and global longitudinal strain (GLS) by speckle-tracking echocardiography 6 months after myocardial infarction. The scar burden was defined by late gadolinium enhancement cardiac magnetic resonance as fraction of total left ventricle tissue...
February 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28188451/patients-with-cheyne-stokes-respiration-and-heart-failure-patient-tolerance-after-three-month-discontinuation-of-treatment-with-adaptive-servo-ventilation
#3
Arild Hetland, Tøri Vigeland Lerum, Kristina H Haugaa, Thor Edvardsen
The recent SERVE HF study concluded that patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) have increased mortality when treated with adaptive servo-ventilation (ASV). We, therefore, wanted to explore if these patients tolerated discontinuation of ASV treatment. The study was a prospective post-ASV treatment observational design with a 3-month follow-up period. 14 patients from our outpatient clinic, all male, were originally diagnosed with CHF and Cheyne-Stokes respiration, which is a clinical form of central sleep apnea...
February 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28130373/catheter-ablation-for-atrial-flutter-a-survey-by-the-european-heart-rhythm-association-and-canadian-heart-rhythm-society
#4
Benedict M Glover, Jian Chen, Kathryn L Hong, Serge Boveda, Adrian Baranchuk, Kristina H Haugaa, Paul Dorian, Tatjana S Potpara, Eugene Crystal, Brent Mitchell, Roland Tilz, Peter Leong-Sit, Nikolaos Dagres
The purpose of this EP wire survey was to examine current practice in the management of both cavotricuspid isthmus (CTI)-dependent and non-CTI-dependent atrial flutter (AFL) ablation amongst electrophysiologists in European and Canadian centres and to understand how current opinions vary from guidelines. The results of the survey were collected from a detailed questionnaire that was created by the European Heart Rhythm Association Research Network and the Canadian Heart Rhythm Society. Responses were received from 89 centres in 12 countries...
December 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28069601/comprehensive-multi-modality-imaging-approach-in-arrhythmogenic-cardiomyopathy-an-expert-consensus-document-of-the-european-association-of-cardiovascular-imaging
#5
Kristina H Haugaa, Cristina Basso, Luigi P Badano, Chiara Bucciarelli-Ducci, Nuno Cardim, Oliver Gaemperli, Maurizio Galderisi, Gilbert Habib, Juhani Knuuti, Patrizio Lancellotti, William McKenna, Danilo Neglia, Bogdan A Popescu, Thor Edvardsen
Arrhythmogenic cardiomyopathy (AC) is a progressive disease with high risk of life-threatening ventricular arrhythmias. A genetic mutation is found in up to 50-60% of probands, mostly affecting desmosomal genes. Diagnosis of AC is made by a combination of data from different modalities including imaging, electrocardiogram, Holter monitoring, family history, genetic testing, and tissue properties. Being a progressive cardiomyopathy, repeated cardiac imaging is needed in AC patients. Repeated imaging is important also for risk assessment of ventricular arrhythmias...
January 9, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28067540/soluble-st2-is-associated-with-disease-severity-in-arrhythmogenic-right-ventricular-cardiomyopathy
#6
Kaspar Broch, Ida S Leren, Jørg Saberniak, Thor Ueland, Thor Edvardsen, Lars Gullestad, Kristina H Haugaa
PURPOSE: Diagnostic and prognostic evaluation remains challenging in arrhythmogenic right ventricular cardiomyopathy (ARVC). We measured plasma concentration of soluble ST2 (sST2) and assessed its association with right ventricular (RV) function and ventricular arrhythmias in patients with ARVC. METHODS: We included patients with ARVC and genotype positive relatives. Soluble ST2 was determined by ELISA. We assessed myocardial function by echocardiography including strain by speckle tracking technique...
January 24, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28057775/catheter-ablation-for-atrial-flutter-a-survey-by-the-european-heart-rhythm-association-and-canadian-heart-rhythm-society
#7
Benedict M Glover, Jian Chen, Kathryn L Hong, Serge Boveda, Adrian Baranchuk, Kristina H Haugaa, Paul Dorian, Tatjana S Potpara, Eugene Crystal, Brent Mitchell, Roland Tilz, Peter Leong-Sit, Nikolaos Dagres
The purpose of this EP wire survey was to examine current practice in the management of both cavotricuspid isthmus : CTI)-dependent and non-CTI-dependent atrial flutter (AFL) ablation amongst electrophysiologists in European and Canadian centres and to understand how current opinions vary from guidelines. The results of the survey were collected from a detailed questionnaire that was created by the European Heart Rhythm Association Research Network and the Canadian Heart Rhythm Society. Responses were received from 89 centres in 12 countries...
January 5, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28017348/late-gadolinium-enhancement-and-the%C3%A2-risk-for-ventricular-arrhythmias-or-sudden%C3%A2-death-in-dilated-cardiomyopathy-systematic-review-and-meta-analysis
#8
Andrea Di Marco, Ignasi Anguera, Matthias Schmitt, Igor Klem, Thomas Neilan, James A White, Marek Sramko, Pier Giorgio Masci, Andrea Barison, Peter Mckenna, Ify Mordi, Kristina H Haugaa, Francisco Leyva, Jorge Rodriguez Capitán, Hiroshi Satoh, Takeru Nabeta, Paolo Domenico Dallaglio, Niall G Campbell, Xavier Sabaté, Ángel Cequier
OBJECTIVES: The aim of this study was to evaluate the association between late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging and ventricular arrhythmias or sudden cardiac death (SCD) in patients with dilated cardiomyopathy (DCM). BACKGROUND: Risk stratification for SCD in DCM needs to be improved. METHODS: A systematic review and meta-analysis were conducted. A systematic search of PubMed and Ovid was performed, and observational studies that analyzed the arrhythmic endpoint (sustained ventricular arrhythmia, appropriate implantable cardioverter-defibrillator [ICD] therapy, or SCD) in patients with DCM, stratified by the presence or absence of LGE, were included...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/28003223/ventricular-arrhythmias-and-reduced-echocardiographic-inferior-wall-strain-is-regional-function-an-important-risk-marker
#9
EDITORIAL
John Gorcsan, Kristina H Haugaa
No abstract text is available yet for this article.
January 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27894062/echocardiographic-comparison-between-left-ventricular-non-compaction-and-hypertrophic-cardiomyopathy
#10
Trine F Haland, Jørg Saberniak, Ida S Leren, Thor Edvardsen, Kristina H Haugaa
BACKGROUND: Modern imaging technology has improved detection of left ventricular non-compaction cardiomyopathy (LVNC). Hypertrophic cardiomyopathy (HCM) shares morphological features with LVNC, but prognosis and treatment strategies differ between LVNC and HCM. METHODS AND RESULTS: We aimed to compare global and regional LV myocardial function in LVNC and HCM. We hypothesized that apical function is reduced in LVNC due to the embryonic reduced compaction of the apex...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27854123/a-retrospective-analysis-of-cardiovascular-outcomes-in-patients-treated-with-asv
#11
Arild Hetland, Kristina H Haugaa, Maria Vistnes, Kristian Hovde Liland, Margareth Olseng, Morten B Jacobsen, Thor Edvardsen
OBJECTIVES: The effect of long-term adaptive servo-ventilation (ASV) on cardiovascular mortality and admission rates in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) has not been much studied. The aim of this study was primarily to investigate whether ASV therapy significantly reduced these parameters. DESIGN: We included 75 CHF patients on optimal medication and CSR ≥25% of sleeping time, in New York Heart Association (NYHA) classes II-IV and left ventricular ejection fraction (LVEF) ≤ 45%...
December 7, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27813299/global-longitudinal-strain-the-best-biomarker-for-predicting-prognosis-in-heart-failure
#12
EDITORIAL
Kristina H Haugaa, Thor Edvardsen
No abstract text is available yet for this article.
November 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27771401/combination-of-ecg-and-echocardiography-for-identification-of-arrhythmic-events-in-early-arvc
#13
Ida S Leren, Jørg Saberniak, Trine F Haland, Thor Edvardsen, Kristina H Haugaa
OBJECTIVES: The aim of this study was to investigate early markers of arrhythmic events (AEs) and improve risk stratification in early arrhythmogenic right ventricular cardiomyopathy (ARVC). BACKGROUND: AEs are frequent in patients with ARVC, but risk stratification in subjects with early ARVC is challenging. METHODS: Early ARVC disease was defined as possible or borderline ARVC diagnosis according to the ARVC Task Force Criteria 2010. We performed resting and signal averaged electrocardiogram (ECG)...
October 14, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27650726/strain-imaging-from-scandinavian-research-to-global-deployment
#14
Thor Edvardsen, Sebastian I Sarvari, Kristina H Haugaa
Knowledge about myocardial function is important for diagnosis, treatment and prediction of the majority of all cardiac diseases. Ejection fraction (EF) by echocardiography has been the preferred diagnostic tool for these purposes, but do have some important limitations. Strain imaging has emerged as a relatively new and important echocardiographic method that will give cardiologists incremental and additional information to EF in several important diseases affecting the myocardium. This paper will give the readers a brief overview on how and when the clinicians can use strain imaging by echocardiography in their daily practice...
October 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27491437/criteria-for-recommendation-and-expert-consensus-papers-from-the-european-association-of-cardiovascular-imaging-scientific-documents-committee
#15
Thor Edvardsen, Nuno Cardim, Bernard Cosyns, Victoria Delgado, Erwan Donal, Raluca Dulgheru, Maurizio Galderisi, Kristina H Haugaa, Philipp A Kaufmann, Patrizio Lancellotti, Massimo Lombardi, Denisa Muraru, Sven Plein, Gerald Maurer, Bogdan A Popescu, Gilbert Habib
The recommendations given in this document are intended as a guide for the writing committees with the aim to harmonize the style and content of EACVI expert consensus and recommendation documents.
October 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27451284/the-jervell-and-lange-nielsen-syndrome-atrial-pacing-combined-with-%C3%A3-blocker-therapy-a-favorable-approach-in-young-high-risk-patients-with-long-qt-syndrome
#16
Andreas Früh, Geir Siem, Henrik Holmström, Gaute Døhlen, Kristina H Haugaa
BACKGROUND: Patients with Jervell and Lange-Nielsen syndrome (JLNS) exhibit severe phenotypes that are characterized by congenital deafness, very long QT intervals, and high risk of life-threatening arrhythmias. Current treatment strategies include high doses of beta-blocker medication, left cardiac sympathetic denervation, and ICD placement, which is challenging in young children. OBJECTIVE: The purpose of this study was to evaluate the safety and effect of pacing in addition to beta-blocker treatment in children with JLNS...
November 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27297231/replacement-of-implantable-cardioverter-defibrillators-and-cardiac-resynchronization-therapy-devices-results-of-the-european-heart-rhythm-association-survey
#17
Roland Tilz, Serge Boveda, Jean-Claude Deharo, Dan Dobreanu, Kristina H Haugaa, Nikolaos Dagres
The aim of this EP Wire was to assess the management, indications, and techniques for implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) device replacement in Europe. A total of 24 centres in 14 European countries completed the questionnaire. All centres were members of the European Heart Rhythm Association Electrophysiology Research Network. Replacement procedures were performed by electrophysiologists in 52% of the centres, by cardiologists in 33%, and both in the remaining centres...
June 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26903598/comparison-of-patients-with-early-phase-arrhythmogenic-right-ventricular-cardiomyopathy-and-right-ventricular-outflow-tract-ventricular-tachycardia
#18
Jørg Saberniak, Ida S Leren, Trine F Haland, Jan Otto Beitnes, Einar Hopp, Rasmus Borgquist, Thor Edvardsen, Kristina H Haugaa
AIMS: Differentiation between early-phase arrhythmogenic right ventricular cardiomyopathy (ARVC) and right ventricular outflow tract (RVOT)-ventricular tachycardia (VT) can be challenging, and correct diagnosis is important. We compared electrocardiogram (ECG) parameters and morphological right ventricular (RV) abnormalities and investigated if ECG and cardiac imaging can help to discriminate early-phase ARVC from RVOT-VT patients. METHODS AND RESULTS: We included 44 consecutive RVOT-VT (47 ± 14 years) and 121 ARVC patients (42 ± 17 years)...
January 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/26873460/strain-echocardiography-is-related-to-fibrosis-and-ventricular-arrhythmias-in-hypertrophic-cardiomyopathy
#19
Trine F Haland, Vibeke M Almaas, Nina E Hasselberg, Jørg Saberniak, Ida S Leren, Einar Hopp, Thor Edvardsen, Kristina H Haugaa
AIMS: Hypertrophic cardiomyopathy (HCM) patients are at risk of ventricular arrhythmias (VAs). We aimed to explore whether systolic function by strain echocardiography is related to VAs and to the extent of fibrosis by cardiac magnetic resonance imaging (CMR). METHODS AND RESULTS: We included 150 HCM patients and 50 healthy individuals. VAs were defined as non-sustained and sustained ventricular tachycardia and aborted cardiac arrest. Left ventricular function was assessed by ejection fraction (EF) and by global longitudinal strain (GLS) assessed by speckle tracking echocardiography...
June 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/26864186/eacvi-ehra-expert-consensus-document-on-the-role-of-multi-modality-imaging-for-the-evaluation-of-patients-with-atrial-fibrillation
#20
Erwan Donal, Gregory Y H Lip, Maurizio Galderisi, Andreas Goette, Dipen Shah, Mohamed Marwan, Mathieu Lederlin, Sergio Mondillo, Thor Edvardsen, Marta Sitges, Julia Grapsa, Madalina Garbi, Roxy Senior, Alessia Gimelli, Tatjana S Potpara, Isabelle C Van Gelder, Bulent Gorenek, Philippe Mabo, Patrizio Lancellotti, Karl-Heinz Kuck, Bogdan A Popescu, Gerhard Hindricks, Gilbert Habib, Nuno M Cardim, Bernard Cosyns, Victoria Delgado, Kristina H Haugaa, Denisa Muraru, Koen Nieman, Giuseppe Boriani, Ariel Cohen
Atrial fibrillation (AF) is the commonest cardiac rhythm disorder. Evaluation of patients with AF requires an electrocardiogram, but imaging techniques should be considered for defining management and driving treatment. The present document is an expert consensus from the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association. The clinical value of echocardiography, cardiac magnetic resonance (CMR), computed tomography (CT), and nuclear imaging in AF patients are challenged...
April 2016: European Heart Journal Cardiovascular Imaging
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