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JOURNAL ARTICLE
Anders W Bjerring, Knut Hb Smeland, Thomas Stokke, Kristina H Haugaa, Espen Holte, Assami Rösner, Cecilie E Kiserud, Thor Edvardsen, Sebastian Imre Sarvari
BACKGROUND: Hodgkin's lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the cardiac health of HL survivors (HLS). METHODS: HLS (n = 246) treated between 1997 and 2007 with anthracycline-based chemotherapy in three centers in Norway were included...
April 4, 2024: Cardio-Oncology
#2
JOURNAL ARTICLE
Ida Gregersen, Morgan Elizabeth Scarth, Rang Abdullah, Per Medbøe Thorsby, Lisa E Hauger, Kristina H Haugaa, Ellen Lund Sagen, Annika E Michelsen, Thor Ueland, Thor Edvardsen, Pål Aukrust, Vibeke Marie Almaas, Astrid Kristine Bjørnebekk, Bente Halvorsen
AIM: In the current paper, we aim to explore the effect of both current and former long-term anabolic-androgenic steroid (AAS) use on regulation of systemic inflammatory markers and mediators of extracellular matrix (ECM) remodeling and their association with hormones and echocardiographic myocardial pathology in weightlifters. METHODS: In a cross-sectional study, 93 weightlifting AAS-users, of which 62 were current and 31 were past users, with at least one-year cumulative AAS-use (mean 11±7 accumulated years of AAS-use), were compared to 54 non-using weightlifting controls (WLC) using clinical interview, blood pressure measurements, and echocardiography...
April 4, 2024: European Journal of Preventive Cardiology
#3
EDITORIAL
Kristina H Haugaa, Eivind W Aabel
No abstract text is available yet for this article.
March 28, 2024: European Heart Journal Cardiovascular Imaging
#4
JOURNAL ARTICLE
Lars G Klaeboe, Øyvind H Lie, Pål H Brekke, Gerhard Bosse, Einar Hopp, Kristina H Haugaa, Thor Edvardsen
Clinical differentiation between athletes' hearts and those with hypertrophic cardiomyopathy (HCM) can be challenging. We aimed to explore the role of speckle tracking echocardiography (STE) and cardiac magnetic resonance imaging (CMR) in the differentiation between athletes' hearts and those with mild HCM. We compared 30 competitive endurance elite athletes (7% female, age 41 ± 9 years) and 20 mild phenotypic mutation-positive HCM carriers (15% female, age 51 ± 12 years) with left ventricular wall thickness 13 ± 1 mm...
February 12, 2024: Biomedicines
#5
JOURNAL ARTICLE
Espen Holte, Tomaž Podlesnikar, Fontes Carvalho, Ahmet Demirkiran, Robert Manka, Gabriela Guzmán Martínez, Błażej Michalski J, Agnès Pasquet Separovic, Hatem Soliman-Aboumarie, Joshi Shruti S, Kristina H Haugaa, Marc R Dweck
AIMS: To evaluate the diagnosis and imaging of patients with mitral regurgitation and the management in routine clinical practice across Europe, the EACVI Scientific Initiatives Committee performed a survey across European centres. In particular, the routine use of echocardiography, advanced imaging modalities, heart valve clinics and heart valve teams was explored. METHODS AND RESULTS: A total of 61 responders, mainly tertiary centres or university hospitals, from 26 different countries responded to the survey, which consisted of 22 questions...
February 22, 2024: European Heart Journal Cardiovascular Imaging
#6
JOURNAL ARTICLE
Stine Marie Havig, Riikka Mari Berg-Pedersen, Hege-Merete Krabseth, Lill Dannevig Müller, Kristina Haugaa, Hasse Khiabani Zare, Knut Gjesdal, Peter Krajci, Mimi Stokke Opdal
Methadone (R,S-methadone) can prolong the QT interval. R-methadone inhibits cardiac potassium channel function less than S-methadone. We tested if switching from methadone to R-methadone would reduce corrected QT (QTc) intervals in methadone maintenance treatment (MMT) patients. Nine patients, with automatically read QTc intervals ≥450 ms, were required to detect a 20 ms (clinically relevant) reduction in QTc intervals with 15 ms standard deviation (SD) and 90% power. Nine stabilized MMT patients, using median (range) 70 (40-120) mg methadone, were included...
February 3, 2024: Basic & Clinical Pharmacology & Toxicology
#7
JOURNAL ARTICLE
Hans Christian Bordado Henriksen, Ingrid Amalia Havnes, Marie Lindvik Jørstad, Rang Abdullah, Per Medbøe Thorsby, Lisa Evju Hauger, Thor Edvardsen, Kristina H Haugaa, Vibeke Marie Almaas, Astrid Bjørnebekk
AIMS: To determine associations between anabolic-androgenic steroid (AAS) use-related morbidity including cardiovascular disease (CVD) and engagement to health services. METHODS: In this cross-sectional study, 90 males with at least 12 months cumulative current or former use of AAS were included. The participants were divided into a treatment-seeking group (TSG) and a non-treatment seeking group (non-TSG) based on their responses to a self-report web questionnaire...
January 2024: Scandinavian Journal of Medicine & Science in Sports
#8
JOURNAL ARTICLE
Ana G Almeida, Julia Grapsa, Alessia Gemelli, Chiara Bucciarelli-Ducci, Bernhard Gerber, Nina Ajmone-Marsan, Anne Bernard, Erwan Donal, Marc R Dweck, Kristina H Haugaa, Krassimira Hristova, Alicia Maceira, Giulia Elena Mandoli, Sharon Mulvagh, Doralisa Morrone, Edyta Plonska-Gosciniak, Leyla Elif Sade, Bharati Schivalkar, Jeanette Schulz-Menger, Leslee Shaw, Marta Sitges, Berlinde von Kemp, Fausto J Pinto, Thor Edvardsen, Steffen E Petersen, Bernard Cosyns
Cardiovascular diseases (CVD) represent an important cause of mortality and morbidity in women. It is now recognized that there are sex differences regarding the prevalence and the clinical significance of the traditional cardiovascular (CV) risk factors as well as the pathology underlying a range of CVDs. Unfortunately, women have been underrepresented in most CVD imaging studies and trials regarding diagnosis, prognosis and therapeutics. There is therefore a clear need for further investigation of how CVD affects women along their life span...
January 10, 2024: European Heart Journal Cardiovascular Imaging
#9
JOURNAL ARTICLE
Richard T Carrick, Corrado De Marco, Alessio Gasperetti, Laurens P Bosman, Jean-Baptiste Gourraud, Alessandro Trancuccio, Andrea Mazzanti, Brittney Murray, Catherine Pendleton, Crystal Tichnell, Harikrishna Tandri, Katja Zeppenfeld, Arthur A M Wilde, Brianna Davies, Colette Seifer, Jason D Roberts, Jeff S Healey, Ciorsti MacIntyre, Wael Alqarawi, Rafik Tadros, Michael J Cutler, Mattia Targetti, Leonardo Calò, Francesco Vitali, Matteo Bertini, Paolo Compagnucci, Michela Casella, Antonio Dello Russo, Chiara Cappelletto, Antonio De Luca, Davide Stolfo, Firat Duru, Henrik K Jensen, Anneli Svensson, Pia Dahlberg, Nina E Hasselberg, Andrea Di Marco, Paloma Jordà, Elena Arbelo, Zoraida Moreno Weidmann, Karolina Borowiec, Antoine Delinière, Elżbieta K Biernacka, J Peter van Tintelen, Pyotr G Platonov, Iacopo Olivotto, Ardan M Saguner, Kristina H Haugaa, Moniek Cox, Claudio Tondo, Marco Merlo, Andrew D Krahn, Anneline S J M Te Riele, Katherine C Wu, Hugh Calkins, Cynthia A James, Julia Cadrin-Tourigny
BACKGROUND AND AIMS: Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences in utilization of primary prevention ICDs and survival free from sustained ventricular arrhythmia (VA) in ARVC. METHODS: This was a retrospective analysis of ARVC patients without prior VA enrolled in clinical registries from 11 countries throughout Europe and North America...
January 9, 2024: European Heart Journal
#10
EDITORIAL
Bernard Cosyns, Kristina H Haugaa
No abstract text is available yet for this article.
November 15, 2023: JACC. Cardiovascular Imaging
#11
JOURNAL ARTICLE
Rang Abdullah, Astrid Bjørnebekk, Lisa E Hauger, Ingunn R Hullstein, Thor Edvardsen, Kristina H Haugaa, Vibeke M Almaas
AIMS: Explore the cardiovascular effects of long-term anabolic-androgenic steroid (AAS)-use in both current and former weightlifting AAS-users, and estimate the occurrence of severe reduced myocardial function and the impact of duration and amount of AAS. METHODS: In this cross-sectional study 101 weightlifting AAS-users with at least one year cumulative AAS-use (mean 11 ± 7 accumulated years of AAS-use) were compared to 71 non-using weightlifting controls (WLC) using clinical data and echocardiography...
November 22, 2023: European Journal of Preventive Cardiology
#12
JOURNAL ARTICLE
Marianne I Forså, Marit K Smedsrud, Kristina H Haugaa, Anders W Bjerring, Andreas Früh, Sebastian I Sarvari, Hege W Landgraff, Jostein Hallén, Thor Edvardsen
AIMS: Echocardiographic characteristics to distinguish physiological left ventricular (LV) hypertrophy from pathology is warranted in early adolescent athletes. This study aimed to explore the phenotype, progression and potential grey zone of LV hypertrophy during adolescence in athletes and hypertrophic cardiomyopathy (HCM) genotype positive patients. METHODS: In this longitudinal observation study, we compared 76 12-year-old athletes to 55 age- and sex-matched HCM genotype positive patients...
November 22, 2023: European Journal of Preventive Cardiology
#13
JOURNAL ARTICLE
Elena Arbelo, Alexandros Protonotarios, Juan R Gimeno, Eloisa Arbustini, Roberto Barriales-Villa, Cristina Basso, Connie R Bezzina, Elena Biagini, Nico A Blom, Rudolf A de Boer, Tim De Winter, Perry M Elliott, Marcus Flather, Pablo Garcia-Pavia, Kristina H Haugaa, Jodie Ingles, Ruxandra Oana Jurcut, Sabine Klaassen, Giuseppe Limongelli, Bart Loeys, Jens Mogensen, Iacopo Olivotto, Antonis Pantazis, Sanjay Sharma, J Peter Van Tintelen, James S Ware, Juan Pablo Kaski
No abstract text is available yet for this article.
November 2023: Giornale Italiano di Cardiologia
#14
JOURNAL ARTICLE
Thuy Mi Nguyen, Daniela Melichova, Eivind W Aabel, Øyvind H Lie, Lars Gunnar Klæboe, Bjørnar Grenne, Benthe Sjøli, Harald Brunvand, Kristina Haugaa, Thor Edvardsen
Our objective was to compare long-term outcomes in patients with non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) between two time periods in Southern Norway. There are limited contemporary data comparing long-term follow-up after revascularization in the last decades. This prospective follow-up study consecutively included both NSTEMI and STEMI patients during two time periods, 2014-2015 and 2004-2009. Patients were followed up for a period of 5 years. The primary outcome was all-cause mortality after 1 and 5 years...
October 18, 2023: Journal of Clinical Medicine
#15
JOURNAL ARTICLE
Christian K Five, Nina E Hasselberg, Linda T Aaserud, Anna Isotta Castrini, Katarina Vlaisavljevic, Øyvind Lie, Christine Rootwelt-Norberg, Eivind W Aabel, Kristina H Haugaa
BACKGROUND AND AIMS: Patients with mitral valve prolapse (MVP) have high risk of life-threatening ventricular arrhythmias (VA). Data on the impact of exercise on arrhythmic risk in these patients is lacking. We explored whether lifetime exercise dose was associated with severe VA and with established risk factors in patients with MVP. Furthermore, we explored the circumstances at the VA event. METHODS: In this retrospective cohort study, we included patients with MVP and assessed lifetime exercise dose as metabolic equivalents of task (MET)hours/week...
October 18, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#16
JOURNAL ARTICLE
Elena Arbelo, Alexandros Protonotarios, Juan R Gimeno, Eloisa Arbustini, Roberto Barriales-Villa, Cristina Basso, Connie R Bezzina, Elena Biagini, Nico A Blom, Rudolf A de Boer, Tim De Winter, Perry M Elliott, Marcus Flather, Pablo Garcia-Pavia, Kristina H Haugaa, Jodie Ingles, Ruxandra Oana Jurcut, Sabine Klaassen, Giuseppe Limongelli, Bart Loeys, Jens Mogensen, Iacopo Olivotto, Antonis Pantazis, Sanjay Sharma, J Peter Van Tintelen, James S Ware, Juan Pablo Kaski
No abstract text is available yet for this article.
October 1, 2023: European Heart Journal
#17
JOURNAL ARTICLE
Feddo P Kirkels, Nick van Osta, Christine Rootwelt-Norberg, Monica Chivulescu, Tim van Loon, Eivind W Aabel, Anna I Castrini, Øyvind H Lie, Folkert W Asselbergs, Tammo Delhaas, Maarten J Cramer, Arco J Teske, Kristina H Haugaa, Joost Lumens
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by fibrofatty replacement of primarily the right ventricular myocardium, a substrate for life-threatening ventricular arrhythmias (VAs). Repeated cardiac imaging of at-risk relatives is important for early disease detection. However, it is not known whether screening should be age-tailored. OBJECTIVES: The goal of this study was to assess the need for age-tailoring of follow-up protocols in early ARVC by evaluating myocardial disease progression in different age groups...
August 29, 2023: Journal of the American College of Cardiology
#18
JOURNAL ARTICLE
Feddo P Kirkels, Christine Rootwelt-Norberg, Laurens P Bosman, Eivind W Aabel, Steven Muller, Anna I Castrini, Karim Taha, Nick van Osta, Øyvind H Lie, Folkert W Asselbergs, Joost Lumens, Anneline S J M Te Riele, Nina E Hasselberg, Maarten J Cramer, Kristina Haugaa, Arco J Teske
BACKGROUND & AIMS: A risk calculator for individualized prediction of first-time sustained ventricular arrhythmia (VA) in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients has recently been developed and validated (www.ARVCrisk.com). This study aimed to investigate whether regional functional abnormalities, measured by echocardiographic deformation imaging, can provide additional prognostic value. METHODS & RESULTS: From two referral centres, 150 consecutive patients with a definite ARVC diagnosis, no prior sustained VA and an echocardiogram suitable for deformation analysis were included (aged 41±17 years, 50% female)...
July 20, 2023: European Heart Journal Cardiovascular Imaging
#19
EDITORIAL
Kristina H Haugaa, Anna I Castrini
No abstract text is available yet for this article.
June 21, 2023: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#20
JOURNAL ARTICLE
Luigi Pannone, Anaïs Gauthey, Giulio Conte, Randy Osei, Daniela Campanale, Enrico Baldi, Paola Berne, Alessandro Vicentini, Pasquale Vergara, Antonio Sorgente, Christine Rootwelt-Norberg, Domenico Giovanni Della Rocca, Cinzia Monaco, Antonio Bisignani, Vincenzo Miraglia, Marcello Spolverini, Gaetano Paparella, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Ströker, Thomy de Ravel, Argelia Medeiros-Domingo, Juan Sieira, Kristina H Haugaa, Pedro Brugada, Mark La Meir, Angelo Auricchio, Gian-Battista Chierchia, Sonia Van Dooren, Carlo de Asmundis
BACKGROUND: Different genes have been associated with idiopathic ventricular fibrillation (IVF); however, there are no studies correlating genotype with phenotype. OBJECTIVES: The aim of this study was to define the genetic background of probands with IVF using large gene panel analysis and to correlate genetics with long-term clinical outcomes. METHODS: All consecutive probands with a diagnosis of IVF were included in a multicenter retrospective study...
May 5, 2023: JACC. Clinical Electrophysiology
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