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Kevin McAdam, James Murphy, Alison Eldridge, Christopher Proctor, Clive Meredith
The concept of a risk continuum for tobacco and nicotine products has been proposed, which differentiates products according to their propensity to reduce toxicant exposure and risk. Cigarettes are deemed the most risky and medicinal nicotine the least. We assessed whether a Reduced-Toxicant Prototype (RTP) cigarette could sufficiently reduce exposure to toxicants versus conventional cigarettes to be considered a distinct category in the risk continuum. We present findings from both pre-clinical and clinical studies in order to examine the potential for reduced smoke toxicant emissions to lower health risks associated with cigarette smoking...
March 8, 2018: Regulatory Toxicology and Pharmacology: RTP
Yi Xu, Ho Jung Ju, S DeBlasio, Elizabeth J Carino, R Johnson, M MacCoss, M Cilia Heck, W Allen Miller, S M Gray
Translational readthrough of the stop codon of the capsid protein (CP) open reading frame (ORF) is used by members of the Luteoviridae to produce their minor capsid protein as a readthrough protein (RTP). The elements regulating RTP expression are not well understood, but involve long-distance interactions between RNA domains. Using high-resolution mass spectrometry, glutamine and tyrosine were identified as the primary amino acids inserted at the stop codon of Potato leafroll virus (PLRV) CP ORF. We characterized the contributions of a cytidine-rich domain immediately downstream, and a branched stem-loop structure 600-700 nucleotides downstream of the CP stop codon...
March 7, 2018: Journal of Virology
Jie Yang, Xu Zhen, Bin Wang, Xuming Gao, Zichun Ren, Jiaqiang Wang, Yujun Xie, Jianrong Li, Qian Peng, Kanyi Pu, Zhen Li
Organic luminogens with persistent room temperature phosphorescence (RTP) have attracted great attention for their wide applications in optoelectronic devices and bioimaging. However, these materials are still very scarce, partially due to the unclear mechanism and lack of designing guidelines. Herein we develop seven 10-phenyl-10H-phenothiazine-5,5-dioxide-based derivatives, reveal their different RTP properties and underlying mechanism, and exploit their potential imaging applications. Coupled with the preliminary theoretical calculations, it is found that strong π-π interactions in solid state can promote the persistent RTP...
February 26, 2018: Nature Communications
Shengyang Li, Guangwei She, Cheng Chen, Shaoyang Zhang, Lixuan Mu, Xiangxin Guo, Wensheng Shi
The Ni in the Ni/n-Si photoanode can not only protect Si from corrosion, but also catalyze the water oxidation reaction. However, the high density of interface states at the Ni/n-Si interface could pin the Fermi level of silicon, which will lower the Schottky barrier height of the Ni/n-Si. As a result, a low photovoltage and consequent high onset potential of Ni/n-Si photoanode for water oxidation were generated. In this study, the interfacial states of the Ni/n-Si photoanodes were efficiently diminished through a rapid thermal process (RTP)...
February 26, 2018: ACS Applied Materials & Interfaces
Florian Wiesinger, Mikael Bylund, Jaewon Yang, Sandeep Kaushik, Dattesh Shanbhag, Sangtae Ahn, Joakim H Jonsson, Josef A Lundman, Thomas Hope, Tufve Nyholm, Peder Larson, Cristina Cozzini
PURPOSE: To describe a method for converting Zero TE (ZTE) MR images into X-ray attenuation information in the form of pseudo-CT images and demonstrate its performance for (1) attenuation correction (AC) in PET/MR and (2) dose planning in MR-guided radiation therapy planning (RTP). METHODS: Proton density-weighted ZTE images were acquired as input for MR-based pseudo-CT conversion, providing (1) efficient capture of short-lived bone signals, (2) flat soft-tissue contrast, and (3) fast and robust 3D MR imaging...
February 18, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Rahim Bahariqushchi, Rosario Raciti, Ahmet Emre Kasapoğlu, Emre Gür, Meltem Sezen, Eren Kalay, Salvatore Salvatore Mirabella, Atilla Aydınlı
Germanium nanocrystals (Ge NCs) embedded in single and multilayer silicon oxide and silicon nitride matrices have been synthesized using plasma enhanced chemical vapor deposition (PECVD) followed by conventional furnace annealing (CFA) or rapid thermal processing (RTP) in N2 ambient. Compositions of the films were determined by Rutherford backscattering spectrometry (RBS) and X-ray photoelectron spectroscopy (XPS). Formation of nanocrystals under suitable process conditions were observed with high resolution transmission electron microscope (HRTEM) micrographs and Raman spectroscopy...
February 16, 2018: Nanotechnology
Christopher L McCrum, Justin W Arner, Bryson Lesniak, James P Bradley
Anterior ankle impingement is a frequent cause of pain and disability in athletes with impingement of soft-tissue or osseous structures along the anterior margin of the tibiotalar joint during dorsiflexion. In this study, we hypothesized that arthroscopic decompression of anterior ankle impingement would result in significant, reliable, and durable improvement in pain and range of motion (ROM), and would allow National Football League (NFL) players to return to their preoperative level of play. We reviewed 29 arthroscopic ankle débridements performed by a single surgeon...
January 2018: American Journal of Orthopedics
Chun-Ling Liu, Chang-Jun Hou, Dan-Qun Huo
In this work, a simple room-temperature phosphorescence (RTP) method was first proposed to detect adriamycin, by using a functional material of Mn doped ZnS quantum dots (Mn-ZnS QDs) composited with poly(diallyldimethylammonium chloride) (PDDA). After PDDA was associated to the Mn-ZnS QDs, the RTP intensity was significantly enhanced. As a result, Mn-ZnS QDs/PDDA nanoassemblies greatly improve the adriamycin detection ability of QDs and provide an important method for developing more effective and sensitive adriamycin detection sensor...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Nicole B Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernández-Garrido, Michael E Rogers, Juan C Colado
The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS: This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no medical history of disease that would preclude them from engaging in physical exercise. Participants were randomly divided into the following groups: elastic tubes with handles group (ETG; n = 22), traditional elastic bands group ( n = 21), and control group (CG; n = 20)...
January 1, 2018: Biological Research for Nursing
Mathew C Halter, James A Zahn
Bacterial-bacteriophage interactions are a well-studied and ecologically-important aspect of microbiology. Many commercial fermentation processes are susceptible to bacteriophage infections due to the use of high-density, clonal cell populations. Lytic infections of bacterial cells in these fermentations are especially problematic due to their negative impacts on product quality, asset utilization, and fouling of downstream equipment. Here, we report the isolation and characterization of a novel lytic bacteriophage, referred to as bacteriophage DTL that is capable of rapid lytic infections of an Escherichia coli K12 strain used for commercial production of 1,3-propanediol (PDO)...
February 7, 2018: Journal of Industrial Microbiology & Biotechnology
Russell R Kempker, Nestani Tukvadze, Lisa Sthreshley, Lisa Sharling, Dawn Comeau, Matthew J Magee, Carlos Del Rio, Zaza Avaliani, Henry M Blumberg
In 2004, there existed limited tuberculosis (TB) research capacity in the country of Georgia. In response, a collaborative research training program (RTP) supported by a National Institutes of Health Fogarty International Center Global Infectious Diseases grant was formed between a U.S. academic institution and the National Center for Tuberculosis and Lung Disease (NCTLD) and other institutions in Georgia. We sought to assess outcomes of this RTP. The TB RTP combined didactic and mentored research training for Georgian trainees...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
Meryem Gülce Subaşı, Gülce Alp, William M Johnston, Burak Yilmaz
OBJECTIVE: To compare the effect of material and thickness on the color stability and relative translucency parameters (RTP) for monolithic ceramics subjected to coffee thermocycling. METHODS: Four specimens each at thicknesses of 0.5, 0,7 and 1 mm were sectioned from monolithic ceramics [preshaded monolithic zirconia (MonZr), lithium disilicate (LDS) and zirconia reinforced lithium silicate (ZLS)]. The specimens were glazed and subjected to 5000 coffee thermocycling...
January 31, 2018: Journal of Dentistry
Rebecca M Lopez, Patrick Tanner, Sarah Irani, P Patrick Mularoni
OBJECTIVE:   To present a functional return-to-play (RTP) progression after exertional heat stroke (EHS) in a 17-year-old high school football defensive end (height = 185 cm, mass = 145.5 kg). BACKGROUND:   The patient had no pertinent medical history but moved to a warm climate several days before the EHS occurred. After completing an off-season conditioning test (14- × 110-yd [12.6- × 99.0-m] sprints) on a warm afternoon (temperature = approximately 34°C [93°F], relative humidity = 53%), the patient collapsed...
January 26, 2018: Journal of Athletic Training
Nick van der Horst
No abstract text is available yet for this article.
January 23, 2018: British Journal of Sports Medicine
Pedro Gargallo, Juan C Colado, Alavaro Juesas, Amaya Hernando-Espinilla, Nuria Estañ-Capell, Lidia Monzó-Beltran, Paula García-Pérez, Omar Cauli, Guillermo T Sáez
This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. METHODS: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands...
January 1, 2018: Biological Research for Nursing
Jeff Beckman, Yuanli Song, Yan Gu, Sergey Voronov, Naresh Chennamsetty, Stanley R Krystek, Nesredin A Mussa, Zheng Jian Li
Capillary Gel Electrophoresis using sodium dodecyl sulfate (CE-SDS) is used commercially to provide quantitative purity data for therapeutic protein characterization and release. In CE-SDS, proteins are denatured under reducing or non-reducing conditions in the presence of SDS and electrophoretically separated by molecular weight and hydrodynamic radius through a sieving polymer matrix. Acceptable performance of this method would yield protein peaks that are baseline resolved and symmetrical. Nominal CE-SDS conditions and parameters are not optimal for all therapeutic proteins, specifically for Recombinant Therapeutic Protein-1 (RTP-1), where acceptable resolution and peak symmetry were not achieved...
January 22, 2018: Analytical Chemistry
Songyuan Tao, Siyu Lu, Yijia Geng, Shoujun Zhu, Simon Redfern, Yubin Song, Tanglue Feng, Weiqing Xu, Bai Yang
Polymer carbon dots (PCDs) are proposed as a new class of room temperature phosphorescence (RTP) materials. The abundant energy levels in PCDs increase the probability of intersystem crossing (ISC) and their covalently-crosslinked framework structures greatly suppress the non-radiative transitions. The efficient methods allow the manufacture of PCDs with unique RTP properties in air without the need for additional metal complexing or for the adopting of complicated matrix compositing. They thus provide a route towards the rational design of metal-free RTP materials that may be synthesized easily...
January 22, 2018: Angewandte Chemie
Dengfeng Li, Feifei Lu, Jie Wang, Wende Hu, Xiao-Ming Cao, Xiang Ma, He Tian
Metal-free room-temperature phosphorescence (RTP) materials offer unprecedented potentials for photoelectric and biochemical materials due to their unique advantages of long lifetime and low-toxicity. However, the achievements of phosphorescence at ambient condition so far have been mainly focused on ordered crystal lattice or on embedding into rigid matrices, where the preparation process might bring out poor repeatability and limited application. In this research, a series of amorphous organic small molecular compounds were developed with efficient room-temperature phosphorescence (RTP) emission through conveniently modifying phosphor moieties to β-cyclodextrin (β-CD)...
January 4, 2018: Journal of the American Chemical Society
Hongbing Fu, Lu Xiao, Yishi Wu, Zhenyi Yu, Zhenzhen Xu, Jinbiao Li, Yanping Liu, Jiannian Yao
Organic room-temperature phosphorescence (ORTP), when combined with external stimuli-responsive capability, is very attractive for sensors and bio-imaging devices, but remains a challengeable task. Herein, by doping two β-iminoenamine-BF2 derivatives (S-2CN and S-2I) into 4-iodoaniline (I-ph-NH2) crystalline matrix, the formation of S-2CN···I-ph-NH2 and S-2I···NH2-ph-I halogen bonds leads to bright red RTP emissions from these two host/guest doped crystals (hgDCs) with quantum efficiencies up to 13.43% and 15...
December 27, 2017: Chemistry: a European Journal
Tanglue Feng, Shoujun Zhu, Qingsen Zeng, Siyu Lu, Songyuan Tao, Junjun Liu, Bai Yang
Involvement of clear photoluminescence (PL) mechanism in specific chemical structure is at the forefront of carbon dots (CDs). Supramolecular interaction exists in plenty of materials, offering an inherent way to administrate the optical and photophysical properties, especially in terms of newly developed polymer carbon dots (PCDs). However, supramolecular-interaction-derived PL regulation is always ignored in the shadow of many kinds of PL factors, and we still have a limited understanding on the distinct chemical structure and mechanism of supramolecular effect in PCDs...
December 4, 2017: ACS Applied Materials & Interfaces
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