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https://www.readbyqxmd.com/read/28771963/organic-nanocrystals-with-bright-red-persistent-room-temperature-phosphorescence-for-biological-applications
#1
Seyed Mohammad Ali Fateminia, Zhu Mao, Zhiyong Yang, Shidang Xu, Zhenguo Chi, Bin Liu
Persistent room-temperature phosphorescence (RTP) in pure organic materials has attracted great attention due to their unique optical properties. The design of organic materials with bright and red persistent RTP remains challenging. Herein, we report a new design strategy for realizing high brightness and long lifetime of red-emissive RTP molecules, which is based on introducing an alkoxy spacer between the hybrid units in the molecule. The spacer offers easy Br-H bond formation during crystallization, which also facilitates intermolecular electron coupling to favor persistent RTP...
August 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28770309/mri-detection-of-soleus-muscle-injuries-in-professional-football-players
#2
G Pezzotta, G Querques, A Pecorelli, R Nani, S Sironi
OBJECTIVES: To describe magnetic resonance imaging (MRI) characteristics of soleus muscle injuries in symptomatic professional football players stratified according to both the Munich consensus statement and the British Athletics Muscle Injury Classification (BAMIC), and to investigate the association between specific MRI features and the "return to play" (RTP). MATERIALS AND METHODS: Professional football players with an episode of acute posterior calf pain and impaired function, subsequent to sports activity, underwent ultrasound followed by MRI examination reviewed by two different radiologists with more than 10 years of experience in the musculoskeletal system...
August 2, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28769016/favipiravir-t-705-a-broad-spectrum-inhibitor-of-viral-rna-polymerase
#3
Yousuke Furuta, Takashi Komeno, Takaaki Nakamura
Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Favipiravir was discovered through screening chemical library for anti-viral activity against the influenza virus by Toyama Chemical Co., Ltd. Favipiravir undergoes an intracellular phosphoribosylation to be an active form, favipiravir-RTP (favipiravir ribofuranosyl-5'-triphosphate), which is recognized as a substrate by RdRp, and inhibits the RNA polymerase activity...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28727937/preoperative-short-form-health-survey-score-is-predictive-of-return-to-play-and-minimal-clinically-important-difference-at-a-minimum-2-year-follow-up-after-anterior-cruciate-ligament-reconstruction
#4
Benedict U Nwachukwu, Brenda Chang, Pramod B Voleti, Patricia Berkanish, Matthew R Cohn, David W Altchek, Answorth A Allen, Riley J Williams
BACKGROUND: There is increased interest in understanding the preoperative determinants of postoperative outcomes. Return to play (RTP) and the patient-reported minimal clinically important difference (MCID) are useful measures of postoperative outcomes after anterior cruciate ligament reconstruction (ACLR). PURPOSE: To define the MCID after ACLR and to investigate the role of preoperative outcome scores for predicting the MCID and RTP after ACLR. STUDY DESIGN: Case-control study; Level of evidence, 3...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28685822/thalamic-connections-of-the-core-auditory-cortex-and-rostral-supratemporal-plane-in-the-macaque-monkey
#5
Brian H Scott, Kadharbatcha S Saleem, Yukiko Kikuchi, Makoto Fukushima, Mortimer Mishkin, Richard C Saunders
In the primate auditory cortex, information flows serially in the mediolateral dimension from core, to belt, to parabelt. In the caudorostral dimension, stepwise serial projections convey information through the primary, rostral, and rostrotemporal (AI, R, and RT) core areas on the supratemporal plane, continuing to the rostrotemporal polar area (RTp) and adjacent auditory-related areas of the rostral superior temporal gyrus (STGr) and temporal pole. In addition to this cascade of corticocortical connections, the auditory cortex receives parallel thalamocortical projections from the medial geniculate nucleus (MGN)...
July 7, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28658080/blood-pressure-response-during-resistance-training-of-different-work-to-rest-ratio
#6
Anderson Caetano Paulo, Valmor Tricoli, Andréia C C Queiroz, Gilberto Laurentino, Cláudia L M Forjaz
Changes in the work to rest ratio (W:R) of resistance training protocols (RTP) (i.e. decreasing work and/or increasing rest) reduce the marked elevation in blood pressure (BP) that occurs during RTP execution. However, whether changes in RTP protocol structure without changing W:R can change BP responses to RTP is unknown. To investigate the effect of different structures of rest intervals and number of repetitions per set on BP response among RTP equated and nonequated for W:R, 20 normotensive participants (25±4 years) performed four different RTP of the leg extension exercise with the same work but different W:R structures...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28657778/successful-return-to-sport-after-arthroscopic-shoulder-stabilization-versus-nonoperative-management-in-contact-athletes-with-anterior-shoulder-instability-a-prospective-multicenter-study
#7
Jonathan F Dickens, John-Paul Rue, Kenneth L Cameron, John M Tokish, Karen Y Peck, C Dain Allred, Steven J Svoboda, Robert Sullivan, Kelly G Kilcoyne, Brett D Owens
BACKGROUND: The debate continues regarding the optimal treatment of intercollegiate contact athletes with in-season anterior shoulder instability. PURPOSE: To examine return to sport and recurrent instability in the season after the index in-season anterior instability event. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: Forty-five contact intercollegiate athletes treated nonoperatively or with arthroscopic stabilization were prospectively followed in a multicenter observational study to evaluate return to play (RTP) and recurrent instability in the season after an initial in-season anterior glenohumeral instability event...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28644678/professional-athletes-return-to-play-and-performance-after-operative-repair-of-an-achilles-tendon-rupture
#8
David P Trofa, J Chance Miller, Eugene S Jang, Denzel R Woode, Justin K Greisberg, J Turner Vosseller
BACKGROUND: Most Achilles tendon ruptures are sports related. However, few studies have examined and compared the effect of surgical repair for complete ruptures on return to play (RTP), play time, and performance across multiple sports. PURPOSE: To examine RTP and performance among professional athletes after Achilles tendon repair and compare pre- versus postoperative functional outcomes of professional athletes from different major leagues in the United States...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28636566/detection-of-muscle-gap-by-l-bia-in-muscle-injuries-clinical-prognosis
#9
L Nescolarde, J Yanguas, J Terricabras, H Lukaski, X Alomar, J Rosell-Ferrer, G Rodas
Sport-related muscle injury classifications are based basically on imaging criteria such as ultrasound (US) and magnetic resonance imaging (MRI) without consensus because of a lack of clinical prognostics for return-to-play (RTP), which is conditioned upon the severity of the injury, and this in turn with the muscle gap (muscular fibers retraction). Recently, Futbol Club Barcelona's medical department proposed a new muscle injury classification in which muscle gap plays an important role, with the drawback that it is not always possible to identify by MRI...
June 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28586385/receptor-transporting-protein-rtp-family-members-play-divergent-roles-in-the-functional-expression-of-odorant-receptors
#10
Teng Yu, Xubo Su, Yi Pan, Hanyi Zhuang
Receptor transporting protein (RTP) family members, RTP1S and RTP2, are accessory proteins to mammalian odorant receptors (ORs). They are expressed in the olfactory sensory neurons and facilitate OR trafficking to the cell-surface membrane and ligand-induced responses in heterologous cells. We previously identified different domains in RTP1S that are important for different stages of OR trafficking, odorant-mediated responses, and interaction with ORs. However, the exact roles of RTP2 and the significance of the requirement of the seemingly redundant co-expression of the two RTP proteins in vivo have received less attention in the past...
2017: PloS One
https://www.readbyqxmd.com/read/28574869/cancer-incidence-estimation-method-an-apulian-experience
#11
Anna M Nannavecchia, Ivan Rashid, Francesco Cuccaro, Antonio Chieti, Danila Bruno, Maria G Burgio Lo Monaco, Cinzia Tanzarella, Lucia Bisceglia
The Cancer Registry of Puglia (RTP) was instituted in 2008 as a regional population-based cancer registry. It consists of six sections (Foggia, Barletta-Andria-Tran, Bari, Brindisi, Lecce, and Taranto) and covers more than 4 000 000 inhabitants. At present, four of six sections have received accreditation by AIRTUM (53% of regional population). To point out possible regional geographic variability in cancer incidence and also to support health services planning, we developed an original estimation method to ensure a complete territorial coverage...
June 1, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28557527/return-to-play-after-shoulder-instability-surgery-in-national-collegiate-athletic-association-division-i-intercollegiate-football-athletes
#12
R Judd Robins, Jimmy H Daruwalla, Seth C Gamradt, Eric C McCarty, Jason L Dragoo, Robert E Hancock, Jeffrey A Guy, George A Cotsonis, John W Xerogeanes, Jeffrey M Tuman, James E Tibone, Matthew A Javernick, Eric M Yochem, Stephanie A Boden, Alexis Pilato, Jennifer H Miley, Patrick E Greis
BACKGROUND: Recent attention has focused on the optimal surgical treatment for recurrent shoulder instability in young athletes. Collision athletes are at a higher risk for recurrent instability after surgery. PURPOSE: To evaluate variables affecting return-to-play (RTP) rates in Division I intercollegiate football athletes after shoulder instability surgery. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Invitations to participate were made to select sports medicine programs that care for athletes in Division I football conferences (Pac-12 Conference, Southeastern Conference [SEC], Atlantic Coast Conference [ACC])...
August 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28554607/cardiorespiratory-fitness-and-body-composition-of-stimulant-users-a-baseline-analysis-of-the-stride-cohort
#13
Mark Stoutenberg, Chad D Rethorst, Denise C Vidot, Tracy L Greer, Madhukar H Trivedi
INTRODUCTION: Relatively little has been reported about the physical characteristics, such as cardiorespiratory fitness (CRF) and body composition, of stimulant users. Identifying risk factors associated with the physical health of stimulant users is an important public health issue as new treatments should better address the entire range of health concerns experienced by this population. METHODS: We examined cross-sectional data gathered at baseline from the STimulant Reduction Intervention using Dosed Exercise (STRIDE) study, a multisite randomized clinical trial that examined exercise as an adjunct to treatment as usual for individuals in residential treatment programs (RTPs)...
July 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28553481/white-light-emission-from-a-single-heavy-atom-free-molecule-with-room-temperature-phosphorescence-mechanochromism-and-thermochromism
#14
Bingjia Xu, Haozhong Wu, Junru Chen, Zhan Yang, Zhiyong Yang, Yuan-Chun Wu, Yi Zhang, Chongjun Jin, Po-Yen Lu, Zhenguo Chi, Siwei Liu, Jiarui Xu, Matthew Aldred
Two heavy atom-free luminophores (SHB2t and SDB2t) with simple molecular structures have been synthesized via Suzuki coupling reactions in which both display white-light emission with prompt fluorescence and room temperature phosphorescence (RTP) in the solid state. The impressive RTP of the luminophores is produced by a synergistic effect of the strong intermolecular hydrogen bonding in addition to the spin-orbit coupling of the sulfonyl oxygen atoms and the moderate singlet-triplet energy gaps (ΔEST). These factors facilitate the intersystem crossing (ISC) process to generate triplet excitons in which the molecular conformations become immobilized to effectively suppress radiationless decay...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28541079/child-gender-influences-paternal-behavior-language-and-brain-function
#15
Jennifer S Mascaro, Kelly E Rentscher, Patrick D Hackett, Matthias R Mehl, James K Rilling
Multiple lines of research indicate that fathers often treat boys and girls differently in ways that impact child outcomes. The complex picture that has emerged, however, is obscured by methodological challenges inherent to the study of parental caregiving, and no studies to date have examined the possibility that gender differences in observed real-world paternal behavior are related to differential paternal brain responses to male and female children. Here we compare fathers of daughters and fathers of sons in terms of naturalistically observed everyday caregiving behavior and neural responses to child picture stimuli...
June 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28528553/protonation-induced-room-temperature-phosphorescence-in-fluorescent-polyurethane
#16
Wei Sun, Zhaowu Wang, Tao Wang, Li Yang, Jun Jiang, Xingyuan Zhang, Yi Luo, Guoqing Zhang
Room-temperature phosphorescence (RTP) from purely organic systems is of practical importance in biological imaging, oxygen sensing and displaying technologies. The key step to obtaining RTP from organic molecules is efficient intersystem crossing (ISC), which is usually low compared to inorganic materials. Here we show that protonation of a dye molecule, a thioflavin derivative, in strongly polar polyurethane can be used to effectively harness RTP. Prior to protonation, the predominant transition is π-π* for the polymer, which has nearly undetectable RTP due to the large singlet-triplet energy splitting (0...
May 26, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28521519/improving-primary-care-provider-practices-in-youth-concussion-management
#17
Kristy B Arbogast, Allison E Curry, Kristina B Metzger, Ronni S Kessler, Jeneita M Bell, Juliet Haarbauer-Krupa, Mark R Zonfrillo, Matthew J Breiding, Christina L Master
Primary care providers are increasingly providing youth concussion care but report insufficient time and training, limiting adoption of best practices. We implemented a primary care-based intervention including an electronic health record-based clinical decision support tool ("SmartSet") and in-person training. We evaluated consequent improvement in 2 key concussion management practices: (1) performance of a vestibular oculomotor examination and (2) discussion of return-to-learn/return-to-play (RTL/RTP) guidelines...
August 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28510477/performance-based-outcomes-after-anterior-cruciate-ligament-reconstruction-in-professional-athletes-differ-between-sports
#18
Harry T Mai, Danielle S Chun, Andrew D Schneider, Brandon J Erickson, Ryan D Freshman, Benjamin Kester, Nikhil N Verma, Wellington K Hsu
BACKGROUND: Excellent outcomes have been reported for anterior cruciate ligament (ACL) reconstruction (ACLR) in professional athletes in a number of different sports. However, no study has directly compared these outcomes between sports. PURPOSE: To determine if differences in performance-based outcomes exist after ACLR between professional athletes of each sport. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: National Football League (NFL), National Basketball Association (NBA), National Hockey League (NHL), and Major League Baseball (MLB) athletes undergoing primary ACLR for an acute rupture were identified through an established protocol of injury reports and public archives...
August 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28476526/restrictive-transfusion-in-radical-cystectomy-is-safe
#19
Sumeet Syan-Bhanvadia, Siri Drangsholt, Swar Shah, Jie Cai, Gus Miranda, Hooman Djaladat, Siamak Daneshmand
INTRODUCTION AND OBJECTIVE: Perioperative blood transfusion (PBT) is commonplace in radical cystectomy (RC) and has been linked to poorer oncologic outcomes. Limiting PBT in this largely elderly and comorbid population has not been studied. Herein, we first investigate the safety of a restrictive transfusion protocol (RTP) in patients undergoing RC for urothelial carcinoma and then compare oncologic outcomes between patients who did and did not receive PBT. METHODS: Outcomes for 173 consecutive patients meeting inclusion criteria undergoing RC for urothelial carcinoma from April 2010 to June 2014 by a single surgeon employing RTP were analyzed from an institutional review board-approved, prospectively collected database...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28451681/ordered-assembly-of-hybrid-room-temperature-phosphorescence-thin-films-showing-polarized-emission-and-the-sensing-of-vocs
#20
Rui Gao, Dongpeng Yan
Benefitting from the self-organization of organic phosphors into 2D galleries of clay nanosheets, we have developed a method for the ordered assembly of long-lived room-temperature phosphorescence (RTP) thin films through a layer-by-layer (LBL) process. The clay-based thin films present polarized RTP and serve as sensors for VOCs.
May 11, 2017: Chemical Communications: Chem Comm
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