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https://www.readbyqxmd.com/read/28102933/what-if-a-tumor-is-significantly-enlarged-just-before-stereotactic-body-radiation-therapy-a-case-report-and-review-of-the-literature
#1
Hung-Jen Chen, Ji-An Liang, Chih-Yi Chen, Yang-Hao Yu, Chun-Ru Chien
Stereotactic body radiation therapy (SBRT) plays an important role in early stage non-small cell lung cancer. Tumor growth before radiotherapy planning (RTP) or during SBRT has been reported in lung cancer patients; however, little is known of growth during the period in-between (i.e. after RTP but before SBRT). An 83-year-old man referred to our hospital and diagnosed with medically inoperable non-small cell lung cancer was noted to have significant tumor progression on day 1 of cone beam computed tomography just before the planned SBRT delivery...
November 18, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/28091573/iron-oxide-films-prepared-by-rapid-thermal-processing-for-solar-energy-conversion
#2
B Wickman, A Bastos Fanta, A Burrows, A Hellman, J B Wagner, B Iandolo
Hematite is a promising and extensively investigated material for various photoelectrochemical (PEC) processes for energy conversion and storage, in particular for oxidation reactions. Thermal treatments during synthesis of hematite are found to affect the performance of hematite electrodes considerably. Herein, we present hematite thin films fabricated via one-step oxidation of Fe by rapid thermal processing (RTP). In particular, we investigate the effect of oxidation temperature on the PEC properties of hematite...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088748/a-dna-probe-based-on-phosphorescent-resonance-energy-transfer-for-detection-of-transgenic-35s-promoter-dna
#3
Jinzhi Lv, Yanming Miao, Jiajia Yang, Jin Qin, Dongxia Li, Guiqin Yan
A QDs-DNA nano-probe was made by combining Mn-doped ZnS room-temperature phosphorescence (RTP) quantum dots (QDs) and DNA. Then an RTP sensor for quantitative detection of genetically-modified mark sequence cauliflower mosaic virus 35S promoter (Ca MV 35S) DNA was built on basis of phosphorescent resonance energy transfer (PRET). The underlying principles were that a QDs-DNA water-soluble nano-probe was built by connecting single-strand DNA to the surfaces of QDs via a ligand exchange method. This probe had good RTP performance and could well identify Ca MV 35S...
January 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28088381/long-term-neurobehavioral-symptoms-and-return-to-productivity-in-operation-enduring-freedom-operation-iraqi-freedom-veterans-with-and-without-traumatic-brain-injury
#4
Marianne H Mortera, Stacy A Kinirons, Jessie Simantov, Heidi Klingbeil
OBJECTIVES: To describe Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans who underwent the Comprehensive Traumatic Brain Injury Evaluation (CTBIE), differences between the traumatic brain injury (TBI) and non- traumatic brain injury (non-TBI) subgroups, and factors associated with return to productivity (RTP). DESIGN: Retrospective medical record review. SETTING: Veterans Affairs Medical Center, Polytrauma/TBI Network Site...
January 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28065992/challenges-surrounding-return-to-play-rtp-for-the-sports-clinician-a-case-highlighting-the-need-for-a-thorough-three-step-rtp-model
#5
Roger Menta, Kevin D'Angelo
Return-to-play (RTP) is a multifactorial process of retuning an injured athlete back to competition when risk for re-injury is minimized. Traditionally, these decisions are made by medical practitioners based on experience or anecdotal evidence. RTP decisions continue to be a challenging task for the medical practitioner. In the interest of advancing sports medicine for the betterment of athletes, improving the RTP decision-making process with a new paradigm has been suggested.1 It stands to clarify the intricacies used by clinicians when making RTP decisions by providing insight into the multiple factors that must be considered; not only by the athlete and medical practitioner, but all relevant parties (i...
December 2016: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28062722/acute-plasma-tau-relates-to-prolonged-return-to-play-after-concussion
#6
Jessica Gill, Kian Merchant-Borna, Andreas Jeromin, Whitney Livingston, Jeffrey Bazarian
OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28048910/su-g-jep2-10-on-the-need-for-a-dynamic-model-for-patient-specific-distortion-corrections-for-mr-only-pelvis-treatment-planning
#7
C Glide-Hurst, W Zheng, C Stehning, S Weiss, S Renisch
PURPOSE: Patient-specific distortions, particularly near tissue/air interfaces, require assessment and possible corrections for MRI-only radiation treatment planning (RTP). However, patients are dynamic due to changes in physiological status and motion during imaging sessions. This work investigated the need for dynamic patient-specific distortion corrections to support pelvis MR-only RTP. METHODS: The pelvises of healthy volunteers were imaged at 1.0T, 1.5T, and 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048796/mo-fg-campus-jep2-04-comparison-study-for-ct-and-mr-only-prostate-imrt-treatment-planning-a-framework-for-the-estimation-of-relative-contribution-of-body-contour-discrepancies-tissue-stratification-and-hu-red-conversion-to-the-overall-dose-difference
#8
M Maspero, P R Seevinck, G Schubert, M Hoesl, G J Meijer, M A Viergever, Jjw Lagendijk, Cat van den Berg
PURPOSE: To compare dose of prostate IMRT plans on CT vs MR-based pseudo-CT (pCT). A framework is demonstrated to isolate various confounding factors causing dose differences. This approach will be valuable for medical physicists interested in commissioning strategy of MR-only dose planning. METHODS: A retrospective study was conducted on fourteen prostate patients that underwent CT and MRI scans. MR was equipped with an in-house-developed flat table-top and coil support...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048437/su-f-t-580-new-tumor-modeling-using-3d-gel-dosimeter-for-brain-stereoctactic-radiotherpy-srt
#9
K Chang, M Kim, J Kwak, S Kim, Y Ji, B Cho, S Yoon, S Lee
PURPOSE: The purpose of this study is to develop new tumor model using 3D printing with 3D dosimeter for brain stereoctactic radiotherpy (SRT). METHODS: BANG(3) polymer gel was prepared and the gel-filled glass vials were irradiated with a 6 MV photon beam to acquire the calibration curve that present the change of R2 (1/T2 ) value with dose. Graded doses from 0 to 12 Gy with an interval of 2 Gy were delivered. A kit for calibration of gel dosimeter and an 2 tumor model phantoms with a spherical shape were produced using a 3D printer with a polylactic acid after its 3D images were created using Autodesk software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047065/we-de-201-09-performance-of-hdr-ring-surface-applicator-printed-by-3d-printer
#10
Z Xu, J Baker, A Hsia, S Ryu
PURPOSE: The commercially available Leipzig-style Cone for High Dose Rate (HDR) Brachytherapy has a steep depth dose curve and a non-uniform dose distribution. This work shows the performance of a Ring Surface Applicator created using a 3D printer that can generate a better dose distribution. Calculated doses were verified with film measurement. METHODS: The water equivalent red-ABS plastic was used to print the Ring Surface Applicator which hosts three catheters: a center piece with a straight catheter and two concentric rings with diameters of 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046932/su-g-jep2-02-a-unifying-multi-atlas-approach-to-electron-density-mapping-using-multi-parametric-mri-for-radiation-treatment-planning
#11
S Ren, W Hara, Q Le, L Wang, L Xing, R Li
PURPOSE: MRI has a number of advantages over CT as a primary modality for radiation treatment planning (RTP). However, one key bottleneck problem still remains, which is the lack of electron density information in MRI. In the work, a reliable method to map electron density is developed by leveraging the differential contrast of multi-parametric MRI. METHODS: We propose a probabilistic Bayesian approach for electron density mapping based on T1 and T2-weighted MRI, using multiple patients as atlases...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046543/su-f-t-513-dosimetric-validation-of-spatially-fractionated-radiotherapy-using-gel-dosimetry
#12
P Papanikolaou, L Watts, E Pappas, G Kalaitzakis, T Maris, N Kirby, K Rasmussen, A Gutierrez, S Stathakis, E Pappas
PURPOSE: Spatially fractionated radiation therapy, also known as GRID therapy, is used to treat large solid tumors by irradiating the target to a single dose of 10-20Gy through spatially distributed beamlets. We have investigated the use of a 3D gel for dosimetric characterization of GRID therapy. METHODS: GRID therapy is an external beam analog of volumetric brachytherapy, whereby we produce a distribution of hot and cold dose columns inside the tumor volume. Such distribution can be produced with a block or by using a checker-like pattern with MLC...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042606/oxygen-sensing-difluoroboron-%C3%AE-diketonate-polylactide-materials-with-tunable-dynamic-ranges-for-wound-imaging
#13
Christopher A DeRosa, Scott A Seaman, Alexander S Mathew, Catherine M Gorick, Ziyi Fan, James N Demas, Shayn M Peirce, Cassandra L Fraser
Difluoroboron β-diketonate poly(lactic acid) materials exhibit both fluorescence (F) and oxygen sensitive room-temperature phosphorescence (RTP). Introduction of halide heavy atoms (Br and I) is an effective strategy to control the oxygen sensitivity in these materials. A series of naphthyl-phenyl (nbm) dye derivatives with hydrogen, bromide and iodide substituents were prepared for comparison. As nanoparticles, the hydrogen derivative was hypersensitive to oxygen (0-0.3%), while the bromide analogue was suited for hypoxia detection (0-3% O2)...
November 23, 2016: ACS Sensors
https://www.readbyqxmd.com/read/28035586/criteria-for-progressing-rehabilitation-and-determining-return-to-play-clearance-following-hamstring-strain-injury-a-systematic-review
#14
REVIEW
Jack T Hickey, Ryan G Timmins, Nirav Maniar, Morgan D Williams, David A Opar
BACKGROUND: Rehabilitation progression and return-to-play (RTP) decision making following hamstring strain injury (HSI) can be challenging for clinicians, owing to the competing demands of reducing both convalescence and the risk of re-injury. Despite an increased focus on the RTP process following HSI, little attention has been paid to rehabilitation progression and RTP criteria, and subsequent time taken to RTP and re-injury rates. OBJECTIVE: The aim of this systematic review is to identify rehabilitation progression and RTP criteria implemented following HSI and examine the subsequent time taken to RTP and rates of re-injury...
December 29, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27956135/effects-of-ribavirin-sofosbuvir-treatment-and-itpa-phenotype-on-endogenous-purines
#15
Leah C Jimmerson, Carolyn W Clayton, Samantha MaWhinney, Eric G Meissner, Zayani Sims, Shyamasundaran Kottilil, Jennifer J Kiser
Ribavirin (RBV), a purine analog, causes hemolytic anemia in some patients. In vitro, anemia appears to result from depletion of endogenous purines, but there are limited data in vivo. Single nucleotide polymorphisms in the gene encoding the inosine triphosphatase (ITPA) enzyme have been associated with protection against RBV-induced anemia and may mediate the effect of RBV treatment on endogenous purines. The purpose of this work was to determine the effect of RBV treatment on endogenous purine concentrations in individuals being treated for chronic hepatitis C virus (HCV) infection...
February 2017: Antiviral Research
https://www.readbyqxmd.com/read/27951527/gene-specific-correlation-of-rna-and-protein-levels-in-human-cells-and-tissues
#16
Fredrik Edfors, Frida Danielsson, Björn M Hallström, Lukas Käll, Emma Lundberg, Fredrik Pontén, Björn Forsström, Mathias Uhlén
An important issue for molecular biology is to establish whether transcript levels of a given gene can be used as proxies for the corresponding protein levels. Here, we have developed a targeted proteomics approach for a set of human non-secreted proteins based on parallel reaction monitoring to measure, at steady-state conditions, absolute protein copy numbers across human tissues and cell lines and compared these levels with the corresponding mRNA levels using transcriptomics. The study shows that the transcript and protein levels do not correlate well unless a gene-specific RNA-to-protein (RTP) conversion factor independent of the tissue type is introduced, thus significantly enhancing the predictability of protein copy numbers from RNA levels...
October 20, 2016: Molecular Systems Biology
https://www.readbyqxmd.com/read/27904796/functional-hop-tests-and-tuck-jump-assessment-scores-between-female-division-i-collegiate-athletes-participating-in-high-versus-low-acl-injury-prone-sports-a-cross-sectional-analysis
#17
Philipp Hoog, Meghan Warren, Craig A Smith, Nicole J Chimera
BACKGROUND: Although functional tests including the single leg hop (SLH), triple hop (TH), cross over hop (COH) for distance, and the tuck jump assessment (TJA) are used for return to play (RTP) criteria for post anterior cruciate ligament (ACL) injury, sport-specific baseline measurements are limited. PURPOSE: The purpose of this study was to examine differences in SLH, TH, and COH distance and limb symmetry index (LSI), as well as total scores, number of jumps, and individual flaws of the TJA in 97 injury-free Division I (DI) collegiate female student athletes participating in ACL injury prone vs...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27886843/expediting-professional-athletes-return-to-competition
#18
REVIEW
Jeff M Coppage, Michelle G Carlson
Return-to-play (RTP) decisions often represent a challenge to physicians caring for athletes. The multifaceted and unique nature of each RTP decision makes standardization of the decision-making process impossible and demands of the physician thoughtful consideration of all competing interests and variables. Such difficult medical decisions are further complicated by unique ethical and legal considerations. Although no concrete RTP recommendations are available, the consensus of experienced team physicians and knowledge of the rules and regulations that apply to RTP are helpful guides to treating the various upper extremity injuries that occur in elite athletes...
February 2017: Hand Clinics
https://www.readbyqxmd.com/read/27862811/induction-of-strong-long-lived-room-temperature-phosphorescence-of-n-phenyl-2-naphthylamine-molecules-by-confinement-in-a-crystalline-dibromobiphenyl-matrix
#19
Jinbei Wei, Baoyan Liang, Ruihong Duan, Zong Cheng, Chenglong Li, Tianlei Zhou, Yuanping Yi, Yue Wang
The design and preparation of metal-free organic materials that exhibit room-temperature phosphorescence (RTP) is a very attractive topic owing to potential applications in organic optoelectronic devices. Herein, we present a facile approach to efficient and long-lived organic RTP involving the doping of N-phenylnaphthalen-2-amine (PNA) or its derivatives into a crystalline 4,4'-dibromobiphenyl (DBBP) matrix. The resulting materials showed strong and persistent RTP emission with a quantum efficiency of approximately 20 % and a lifetime of a few to more than 100 milliseconds...
December 12, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27853664/return-to-play-after-cervical-spine-injuries-a-consensus-of-opinion
#20
John C France, Michael Karsy, James S Harrop, Andrew T Dailey
Study Design Survey. Objective Sports-related spinal cord injury (SCI) represents a growing proportion of total SCIs but lacks evidence or guidelines to guide clinical decision-making on return to play (RTP). Our objective is to offer the treating physician a consensus analysis of expert opinion regarding RTP that can be incorporated with the unique factors of a case for clinical decision-making. Methods Ten common clinical scenarios involving neurapraxia and stenosis, atlantoaxial injury, subaxial injury, and general cervical spine injury were presented to 25 spine surgeons from level 1 trauma centers for whom spine trauma is a significant component of their practice...
December 2016: Global Spine Journal
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