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Ning Zeng, Tang Hongbo, Yi Xu, Min Wu, Yiping Wu
Skin cancer is one of the primary causes of mortality worldwide. With an increasing frequency of skin cancers, there is an urgent requirement for the development of numerous treatment options. The present study investigated the anticancer activity of caffeic acid n‑butyl ester (CAE) against the A431 skin cancer cell line. Antiproliferative effects were investigated using an MMT assay. Apoptosis was examined by DAPI and Annexin V/fluorescein isothiocyanate and propidium iodide staining. Reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and cell cycle analyses were performed via flow cytometry...
February 13, 2018: Molecular Medicine Reports
Marietta L van der Linden, Sadaf Jahed, Nicola Tennant, Martine H G Verheul
OBJECTIVES: RaceRunning enables athletes with limited or no walking ability to propel themselves independently using a three-wheeled running bike that has a saddle and a chest plate for support but no pedals. For RaceRunning to be included as a Para athletics event, an evidence-based classification system is required. Therefore, the aim of this study was to assess the association between a range of impairment measures and RaceRunning performance. METHODS: The following impairment measures were recorded: lower limb muscle strength assessed using Manual Muscle Testing (MMT), selective voluntary motor control assessed using the Selective Control Assessment of the Lower Extremity (SCALE), spasticity recorded using both the Australian Spasticity Assessment Score (ASAS) and Modified Ashworth Scale (MAS), passive range of motion (ROM) of the lower extremities and the maximum static step length achieved on a stationary bike (MSSL)...
February 5, 2018: Gait & Posture
Einat Peles, Shaul Schreiber, Anat Sason, Miriam Adelson
BACKGROUND: Environmental and social trends and patients' characteristics may affect predictors for methadone maintenance treatment (MMT) outcome. METHODS: We have expanded our previous study of predictors for MMT outcome (from 619 to 890 patients) and the study period (from 15 to 24 years). Survival and retention in MMT since admission to the MMT clinic (6/1993-6/2016) and until death or study closure (6/2017) were compiled and analyzed. RESULTS: Of 890 patients ever admitted (10,146...
February 7, 2018: Drug and Alcohol Dependence
Jill-Desiree Brederson, Katharine L Chu, Jun Xu, Arthur L Nikkel, Stella Markosyan, Michael F Jarvis, Rebecca Edelmayer, Robert S Bitner, Steve McGaraughty
Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, however, the cellular mechanisms underlying OA are not fully understood. We characterized the medial meniscal tear (MMT) surgical model and the intra-articular injection of monosodium iodoacetate (MIA) chemical model of OA in rats. Both models produced histological changes in the knee joint and associated bones consistent with OA pathology...
February 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Helene Alexanderson, Malin Regardt, Christina Ottosson, Li Alemo Munters, Maryam Dastmalchi, Lara Dani, Ingrid E Lundberg
OBJECTIVE: To investigate muscle impairment (isometric and dynamic) and disease activity during the first year after diagnosis of polymyositis (PM) and dermatomyositis (DM), and to study the relationship between muscle impairment, patient-reported health, and disease activity. METHODS: Seventy-two patients enrolled in the Swedish Myositis Register, 2003-2010, were followed prospectively. The Manual Muscle test (MMT-8; isometric muscle strength), the Functional Index of myositis test (FI-2; dynamic, repetitive muscle function), and disease activity (6-item core set) were retrieved at the time of diagnosis, and after 6 and 12 months...
February 1, 2018: Journal of Rheumatology
Anat Sason, Miriam Adelson, Sarit Herzman-Harari, Einat Peles
Methadone maintenance treatment (MMT) patients are often under-nourished and overweight. The impact of a nutrition intervention program to improve knowledge about healthy food habits and losing weight was studied. Patients were screened for knowledge about nutrition and body mass index (BMI). Those with a low knowledge score or a BMI ≥26 (n=89) were randomly divided into either intervention (two lectures on healthy nutrition followed by weight monitoring over 6weeks), or controls (weighed at baseline, post-lectures and at study closure)...
March 2018: Journal of Substance Abuse Treatment
Lauren Brinkley-Rubinstein, Michelle McKenzie, Alexandria Macmadu, Sarah Larney, Nickolas Zaller, Emily Dauria, Josiah Rich
Recently, incarcerated individuals are at increased risk of opioid overdose. Methadone maintenance treatment (MMT) is an effective way to address opioid use disorder and prevent overdose; however, few jails and prisons in the United States initiate or continue people who are incarcerated on MMT. In the current study, the 12 month outcomes of a randomized control trial in which individuals were provided MMT while incarcerated at the Rhode Island Department of Corrections (RIDOC) are assessed. An as-treated analysis included a total of 179 participants-128 who were, and 51 who were not, dosed with methadone the day before they were released from the RIDOC...
January 31, 2018: Drug and Alcohol Dependence
Faustyna Manikowska, Brian Po-Jung Chen, Marek Jóźwiak, Maria K Lebiedowska
BACKGROUND: Weakness is a major impairment in many movement disorders, including cerebral palsy (CP), which presents as a decrease in muscle strength. Manual muscle testing (MMT) is very popular in clinical practice, however it has many limitations. OBJECTIVE: (1) Whether maximum voluntary contraction (MVC) measures differ across clinical MMT groups; (2) Whether an association exists between clinical MMT score groups and instrumental MVC measures. METHODS: Twenty-one participants with spastic CP were recruited (11 females and 10 males; age = 13...
2018: NeuroRehabilitation
Noriko Sueoka, Mariko Ishizuka, Katsuhiro Yoshikawa, Yu Tsubota, Daigo Yamamoto, Masanori Kon
We introduced stereotactic mammotome biopsy(ST-MMT)for the purpose of screening and other institutions. There are many benign cases to be diagnosed by pathological findings, so it is thought to be necessary to examine the adaptation of STMMT again. We examined the performance of ST-MMT in a case of a non-palpating calcification lesion. Between August 2013 and December 2016, ST-MMT biopsies were performed for 247 microcalcified lesions revealed by mammography(in both breasts in 9 patients; twice in the ipsilateral breast in 2 patients)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Guido Mannaioni, Cecilia Lanzi, Michela Lotti, Valentina Galli, Arianna Totti, Ilaria Pacileo, Maria Sili, Chiara Pracucci, Arianna Dilaghi, Lara Bertieri, Mariarita Quaranta, Francesco Orsini, Brunella Occupati, Assia Michahelles, Riccardo Ciuti, Elisa Bianchini, Giancarlo Fabbro, Annibale Biggeri, Emanuela Masini, Flavio Moroni
AIMS: We aimed to improve the retention in treatment and therapeutic outcome of methadone maintenance treatment (MMT) patients by adjusting the oral methadone dose in order to reach a "target" plasma R-methadone level (80-250 ng/mL). METHODS: A multicenter randomized controlled trial was organized. RESULTS: The intention-to-treat statistical analysis showed that repeated dose adjustments performed in order to obtain therapeutic plasma R-methadone levels did not improve retention in treatment of heroin-dependent patients...
January 31, 2018: European Addiction Research
H Thagira Banu, P Karthikeyan, Sankaran Meenakshi
In the present work, lanthanum encapsulated chitosan-montmorillonite composite (La-CS-MMT) was prepared as an adsorbent for the effective removal of phosphate ions from aqueous solution. Characterization of the adsorbent using FT-IR, XRD, SEM with EDX, TGA and DTA techniques were carried out. Batch adsorption experiments were carried out to optimize the effects of various operating parameters viz., shaking time, initial concentration of phosphate ions, dosage, competitor co-existing ions, pH and temperature...
January 26, 2018: International Journal of Biological Macromolecules
Nan Feng, Chunqing Lin, Julie Hsieh, Keming Rou, Li Li
BACKGROUND: The use of heroin during Methadone Maintenance Treatment (MMT) is a challenging problem that contributes to poor treatment outcomes. Families may play an important role in addressing concurrent heroin use during MMT, especially in collectivist societies such as China. OBJECTIVES: In this study, we explored the relationship between family-related factors and concurrent heroin use during MMT in China. METHODS: This study was conducted at 68 MMT clinics in five provinces of China...
January 29, 2018: Substance Use & Misuse
Norio Kamemura
Methylcyclopentadienyl manganese tricarbonyl (MMT) is used as a gasoline antiknock additive. However, the toxic effect of MMT is currently not well understood. In this study, we investigated the toxic effect of MMT on rat thymocytes using a flow cytometer and fluorescent probes. MMT at 100-300 µM significantly increased the population of cells exhibiting propidium fluorescence, i.e., the population of dead cells. The intensity of BES-So-AM fluorescence significantly increased when using 100 µM MMT. In addition, the intensity of oxonol fluorescence in rat thymocytes increased with the treatment with MMT in a concentration-dependent manner (10-100 µM)...
January 23, 2018: Drug and Chemical Toxicology
Bach Xuan Tran, Long Hoang Nguyen, Tung Thanh Tran, Carl A Latkin
INTRODUCTION: Methadone maintenance treatment (MMT) services may reduce the risk of HIV transmission if patients completely adhere to the treatment. Identifying adherence patterns and potential related factors is vital for the sustainability of MMT program in Vietnam. This study examined social and structural factors associated with adherence to MMT among patients in different service delivery models. MATERIALS AND METHODS: A total of 510 patients at three MMT clinics in Hanoi were interviewed...
2018: PloS One
Kelly E Moore, Lindsay Oberleitner, Kathryn M Z Smith, Kathleen Maurer, Sherry A McKee
BACKGROUND: Methadone maintenance treatment (MMT) is underutilized in correctional settings, and those receiving MMT in the community often undergo withdrawal upon incarceration. Federal and state regulations present barriers to providing methadone in correctional facilities. For this investigation, a community provider administered methadone to inmates who had been receiving methadone prior to incarceration. We hypothesized that inmates continued on MMT would have improved behavior during incarceration and post-release...
January 16, 2018: Journal of Addiction Medicine
Chia-Chen Liu, Chiu-Ping Fang, Tung-Hsia Liu, Hsiang-Wei Kuo, Shu Chi Liu, Sheng-Chang Wang, Andrew C H Chen, Yu-Li Liu
APBB2, amyloid beta (A4) precursor protein-binding family B member 2, has been reported to be associated with opioid dependence. In this study, we reported the first time that the genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients undergoing methadone maintenance treatment (MMT). 344 heroin-dependent patients undergoing MMT were recruited and assessed for use of amphetamine and opioids by urine toxicology, withdrawal severity, and side effects. DNAs were genome-widely genotyped for all patients...
January 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
A D M Koopman, F Rutters, S P Rauh, G Nijpels, J J Holst, J W Beulens, M Alssema, J M Dekker
We conducted the first prospective observational study in which we examined the association between incretin responses to an oral glucose tolerance test (OGTT) and mixed meal test (MMT) at baseline and changes in fasting glucose levels 7 years later, in individuals who were non-diabetic at baseline. We used data from the Hoorn Meal Study; a population-based cohort study among 121 subjects, aged 61.0±6.7y. GIP and GLP-1 responses were determined at baseline and expressed as total and incremental area under the curve (tAUC and iAUC)...
2018: PloS One
Yanfen Fang, Ao Zhou, Wei Yang, Tirusew Araya, Yingping Huang, Ping Zhao, David Johnson, Jianzhu Wang, Zhiyong Jason Ren
This study investigates the adsorption mechanism differences among four nitrogenous dyes, sulforhodamine G (SRG), uncharged/deprotonated rhodamine B (RhB), orange II (Or II) and methyl blue (MB) by montmorillonite (MMT). MMT adsorption capacity for cationic MB was three times that of uncharged RhB and anionic SRG, while anionic Or II was not absorbed. Colloidal MMT particles have two types of surfaces, basal and edge, that interact with nitrogenous dyes very differently. The surface acidity of MMT was characterized with the pyridine adsorption method using in-situ diffuse reflectance infrared Fourier transform spectroscopy (in-situ DRIFTS)...
January 10, 2018: Scientific Reports
Xia Zou, Yong Xu, Wen Chen, Yinghua Xia, Yin Liu, Cheng Gong, Li Ling
BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections among methadone maintenance treatment (MMT) participants remain high. Optimized HIV and HCV prevention strategies for MMT clinics in resource-limited regions are urgently needed. This study aims to develop an MMT system dynamic model (SDM) to compare and optimize HIV and HCV control strategies in the MMT system. METHODS: We developed an MMT-SDM structure based on literature reviews...
January 10, 2018: Substance Abuse Treatment, Prevention, and Policy
Hyeok Choi
Previously, the concept of reactive activated carbon (RAC), where the porous structure of activated carbon (AC) is impregnated with palladized zerovalent iron, has been proposed to be effective to adsorb and dechlorinate polychlorinated biphenyls (PCBs). To explain the low dechlorination of PCBs bound to actual aquatic sediments under remediation with RAC, this study investigated the role of various solid organic and inorganic sediment components in adsorbing and desorbing PCBs. Detailed fate and transport mechanism of 2-chlorinated biphenyl (2-ClBP) spiked to sediment components, including kaolin, montmorillonite (MMT), coal, graphite, AC, and their mixture, was revealed...
December 17, 2017: Journal of Hazardous Materials
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