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Lyubomir I Aftanas, Olga M Bazanova, Nataliya V Novozhilova
Background: Recent studies have demonstrated that the assessment of postural performance may be a potentially reliable and objective marker of the psychomotor retardation (PMR) in the major depressive disorder (MDD). One of the important facets of MDD-related PMR is reflected in disrupted central mechanisms of psychomotor control, heavily influenced by compelling maladaptive depressive rumination. In view of this we designed a research paradigm that included sequential execution of simple single-posture task followed by more challenging divided attention posture tasks, involving concurring motor and ideomotor workloads...
2018: Frontiers in Human Neuroscience
Ali Olad, Mahyar Pourkhiyabi, Hamed Gharekhani, Fatemeh Doustdar
Semi-interpenetrating polymer network (semi-IPN) superabsorbent nanocomposite based on montmorillonite (MMT) and sodium alginate (NaAlg)-g-poly(acrylic acid(AA))/polyvinylpyrrolidone (PVP) was synthesized. Chemical structure and surface morphology of the hydrogels were characterized by FTIR, XRD, thermogravimetric analysis (TGA), SEM, and TEM techniques. FTIR results revealed that graft polymerization, PVP interpenetration through hydrogel network, and nanocomposite formation have occurred. The coarse surface of the hydrogels was changed into interlinked porous structures in the presence of MMT...
June 15, 2018: Carbohydrate Polymers
Muhammad Asif Javaid, Rasheed Ahmad Khera, Khalid Mahmood Zia, Kei Saito, Ijaz Ahmad Bhatti, Muhammad Asghar
A series of chitosan (CS) and montmorillonite (MMT) clay based polyurethane bio-nanocomposites were synthesized by step growth polymerization; reacting hydroxyl terminated polybutadiene (HTPB) and toluene diisocyanate (TDI) to improve thermal and antibacterial properties of polyurethane (PU). Five different PU samples were prepared by varying mole ratio of CS and 1,4-butane diol (from 0 to 2 mol). Structural studies of PUs through FTIR and1 H NMR spectroscopy confirmed the incorporation of CS into the polymer matrix...
April 5, 2018: International Journal of Biological Macromolecules
Jun Ma, Zhu Wang, Jianquan Zhao, WuJun Miao, TianWen Ye, Aimin Chen
BACKGROUND LPS-inhibited osteoblastic differentiation plays an important role in the pathogenesis of osteomyelitis. Thus, searching for drugs that affect LPS-mediated osteoblastic differentiation may be crucial in developing therapies for osteomyelitis. The purpose of this study was to investigate the role and mechanisms of resveratrol, a natural polyphenol present in red wine, on LPS-inhibited osteoblastic differentiation. MATERIAL AND METHODS Cell viability was measured by MMT assay. Mitochondrial ATP levels, membrane potential, and superoxide production were measured to evaluate the effects of LPS and resveratrol on mitochondrial functions in osteoblast-like MC3T3-E1 cells...
April 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Tetsuro Ishimatsu, Koichi Kinoshita, Jun Nishio, Jun Tanaka, Satohiro Ishii, Takuaki Yamamoto
BACKGROUND: During the direct anterior approach for total hip arthroplasty, a retractor is placed on the anterior wall of the acetabulum to retract the iliopsoas muscle. This step with the retractor has been reported to put the patient at risk for femoral nerve damage. The present study aimed to clarify the effects of the anterior acetabular retractor on the status of the femoral nerve during the direct anterior approach on the basis of transcranial motor-evoked potential (MEP) analysis...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
Milad Parpouchi, Akm Moniruzzaman, Stefanie N Rezansoff, Angela Russolillo, Julian M Somers
BACKGROUND: Opioid overdose deaths have become a public health crisis in North America, and those who are homeless are particularly vulnerable. Methadone maintenance treatment (MMT) may prevent overdose and death among homeless people with opioid dependence, but suboptimal medication adherence is a common limitation. Previous research found that Housing First (HF) increases antipsychotic medication adherence among formerly homeless people. However, no experimental trials have examined whether HF has a significant impact on MMT adherence...
March 30, 2018: International Journal on Drug Policy
Thomas Nittoli, Marcus P Kelly, Frank Delfino, John Rudge, Arthur Kunz, Thomas Markotan, Jan Spink, Zhaoyuan Chen, Jing Shan, Elizabeth Navarro, Michele Tait, Kathleen Provoncha, Jason Giurleo, Feng Zhao, Xiaobo Jiang, Donna Hylton, Sosina Makonnen, Carlos Hickey, Jessica R Kirshner, Gavin Thurston, Nicholas Papadopoulos
Natural products have been used for many medicinal purposes for centuries. Antibody drug conjugates (ADCs) have utilized this rich source of small molecule therapeutics to produce several clinically useful treatments. ADCs based on the natural product maytansine have been successful clinically. The authors further the utility of the anti-cancer natural product maytansine by developing efficacious payloads and linker-payloads for conjugating to antibodies. The success of our approach was realized in the EGFRvIII targeting ADC EGFRvIII-16...
February 21, 2018: Bioorganic & Medicinal Chemistry
Jan Klimas, Ekaterina Nosova, Eugenia Socías, Seonaid Nolan, Rupinder Brar, Kanna Hayashi, M-J Milloy, Thomas Kerr, Evan Wood
BACKGROUND: We sought to examine the factors associated with discontinuation of MMT among persons on methadone who use alcohol. METHODS: We evaluated the impact of drug-related and other factors on discontinuation of MMT among persons enrolled in MMT and who reported any use of alcohol versus those who were enrolled in two community-recruited prospective cohorts of people who use illicit drugs (PWUD). Extended Cox models with time-dependent variables identified factors independently associated with time to first MMT discontinuation...
March 23, 2018: Drug and Alcohol Dependence
Pierrette Baschung Pfister, Eling D de Bruin, Iris Sterkele, Britta Maurer, Rob A de Bie, Ruud H Knols
Manual muscle testing (MMT) and hand-held dynamometry (HHD) are commonly used in people with inflammatory myopathy (IM), but their clinimetric properties have not yet been sufficiently studied. To evaluate the reliability and validity of MMT and HHD, maximum isometric strength was measured in eight muscle groups across three measurement events. To evaluate reliability of HHD, intra-class correlation coefficients (ICC), the standard error of measurements (SEM) and smallest detectable changes (SDC) were calculated...
2018: PloS One
Patrick T Brennan, Jesus M Villa, Mark D Rossi, Marcos A Sanchez-Gonzalez, Carlos J Lavernia
Objective: To determine whether any strength, range of motion (ROM), or functional improvement exists in the adductor canal block (ACB) group after completion of inpatient rehabilitation and following the removal of the continuous block. Design: Retrospective cohort. Setting: Inpatient rehabilitation at discharge and outpatient orthopedic clinic for follow-up. Participants: Two hundred forty-six consecutive primary total knee arthroplasties (TKAs; N = 221 patients) performed by a single surgeon in a single institution between July 2013 and August 2015 for a diagnosis of osteoarthritis...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
Fatih Tornuk, Osman Sagdic, Mehmet Hancer, Hasan Yetim
In this study, a novel procedure was performed for grafting of nanoclays (montmorillonite (MMT) and halloysite (HNT)) with essential oil constituents (thymol (THY), eugenol (EUG) and carvacrol (CRV)) using Tween 80 as surfactant and then the nanoclay particles were incorporated into LLDPE pellets (5 wt%) to produce active nanocomposite films using a twin screw extruder. The resulting nanocomposite films were analyzed for antimicrobial and antioxidant capacity as well as thickness, mechanical, color, barrier, thermal properties and surface morphology and molecular composition...
May 2018: Food Research International
Hao Chen, Zi Ye, Lin Sun, Xi Li, Shuai Shi, Jiajiang Hu, Yingying Jin, Qingwen Xu, Bailiang Wang
The over- and inefficient release of antibiotics from common delivery systems causes the development of drug-resistant bacteria. In the present work, methoxy poly(ethylene glycol)-poly(ε-caprolactone)-chitosan/montmorillonite (MPC/MMT) hybrid multilayer films were constructed for bacterial infections and pH-dependent release of the hydrophobic drug triclosan (TCA). The thickness of the (MPC-T/MMT)10 multilayer films was 384.4 ± 26.5 nm, and the TCA loading dosage was 2.4 μg/cm2 . Staphylococcus aureus, Escherichia coli and Staphylococcus epidermidis were used in the antibacterial tests...
June 1, 2018: Carbohydrate Polymers
Lianping Ti, María Eugenia Socías, Evan Wood, M-J Milloy, Ekaterina Nosova, Kora DeBeck, Thomas Kerr, Kanna Hayashi
BACKGROUND & AIMS: People who inject drugs (PWID) living with hepatitis C virus (HCV) infection often experience barriers to accessing HCV treatment and care. New, safer and more effective direct-acting antiviral-based therapies offer an opportunity to scale-up HCV-related services. Methadone maintenance therapy (MMT) programs have been shown to be effective in linking PWID to health and support services, largely in the context of HIV. The objective of the study was to examine the relationship between being enrolled in MMT and having access to regular physician care regarding HCV among HCV antibody-positive PWID in Vancouver, Canada...
2018: PloS One
Robert E Pyke, Anita H Clayton
BACKGROUND: Regarding hypoactive sexual desire disorder (HSDD) in women, some reviewers judge the effect size small for medications vs placebo, but substantial for cognitive behavior therapy (CBT) or mindfulness meditation training (MMT) vs wait list. However, we lack comparisons of the effect sizes for the active intervention itself, for the control treatment, and for the differential between the two. AIM: For efficacy trials of HSDD in women, compare effect sizes for medications (testosterone/testosterone transdermal system, flibanserin, and bremelanotide) and placebo vs effect sizes for psychotherapy and wait-list control...
March 22, 2018: Sexual Medicine Reviews
Dian-Jeng Li, Kuan-Shang Chung, Hung-Chi Wu, Chih-Yao Hsu, Cheng-Fang Yen
BACKGROUND: Methadone maintenance treatment (MMT) has been shown to be an effective therapeutic strategy for opioid users. This study aimed to investigate the predictive effect of clinically predominant sleep disturbance (CPSD) on the dose of methadone among opiate users receiving MMT during a follow-up period of 6 years in Taiwan. METHODS: This retrospective study included 1,290 individuals with opioid dependence who visited our MMT clinic for the first time. Generalized estimating equations were used to analyze the effect of CPSD on the daily dose of methadone by controlling for the effects of demographic and MMT characteristics...
March 23, 2018: American Journal on Addictions
Bach Xuan Tran, Victoria L Boggiano, Huong Lan Thi Nguyen, Long Hoang Nguyen, Hung Van Nguyen, Canh Dinh Hoang, Huong Thi Le, Tho Dinh Tran, Hai Quan Le, Carl A Latkin, Thuc Minh Thi Vu, Melvyn Wb Zhang, Roger Cm Ho
OBJECTIVES: With the rise in methadone maintenance therapy (MMT) for drug users in Vietnam, there has been growing interest in understanding if and how often MMT patients engage in concurrent illicit drug use while on methadone therapy in various settings. This study examined factors associated with concurrent opioid use among patients on MMT in a mountainous area in Vietnam. SETTING: One urban and one rural MMT clinics in Tuyen Quang province. PARTICIPANTS: Survey participants consisted of patients who were taking MMT at the selected study sites...
March 22, 2018: BMJ Open
Liane E Tellier, Elda A Treviño, Alexandra L Brimeyer, David S Reece, Nick J Willett, Robert E Guldberg, Johnna S Temenoff
As a potential treatment for osteoarthritis (OA), we have developed injectable and hydrolytically degradable heparin-based biomaterials with tunable sulfation for the intra-articular delivery of tumor necrosis factor-alpha stimulated gene-6 (TSG-6), a protein known to inhibit plasmin which may degrade extracellular matrix within OA joints. We first assessed the effect of heparin sulfation on TSG-6 anti-plasmin activity and found that while fully sulfated (Hep) and heparin desulfated at only the N position (Hep-N) significantly enhanced TSG-6 bioactivity in vitro, fully desulfated heparin (Hep-) had no effect, indicating that heparin sulfation plays a significant role in modulating TSG-6 bioactivity...
March 22, 2018: Biomaterials Science
Guijie Luan, Peng Yin, Lijun Wang, Maigeng Zhou
We aim to explore the Minimum Mortality Temperature (MMT) of different cities and regions, and that provides evidence for developing reasonable heat wave definition in China. The death data of 31 Chinese provincial capital cities from seven geographical regions during 2008-2013 was included in this study. In the first stage, a DLNM (Distributed Lag Non-linear Model) was used to estimate the association between mean temperature and mortality in a single city, then we pooled them with a multivariate meta-analysis to estimate the region-specific effects...
March 21, 2018: International Journal of Environmental Health Research
Hiroyuki Awano, Chieko Itoh, Yasuhiro Takeshima, Tomoko Lee, Masaaki Matsumoto, Akihiro Kida, Toshihiko Kaise, Takeo Suzuki, Masafumi Matsuo
INTRODUCTION: Few long-term cohort studies have addressed changes in the ambulatory capacity of patients with Duchenne muscular dystrophy (DMD), and no reports have evaluated the factors associated with ambulatory capacity in Japanese. METHODS: The longitudinal changes in 10-meter run/walk ability and associated factors were retrospectively investigated using general practice data. The factors associated with loss of this ability before the age of 10 years were explored by logistic regression analysis using parameters of genetic mutations, corticosteroid use, the manual muscle test (MMT), and the joint range of motion (ROM)...
March 15, 2018: Brain & Development
Thai Hoang, Hong Nguyen, Ray W Shiraishi, Mai Nguyen, Trista Bingham, Diep Nguyen, Tam Nguyen, Hao Duong, Sheryl Lyss, Hien Tran
BACKGROUND: Methadone maintenance treatment (MMT) is highly effective for reducing heroin use and HIV transmission among people who inject opioids. We sought to measure and understand factors associated with continued heroin use, a critical factor affecting treatment outcome among MMT patients in Vietnam. METHOD: We collected data from medical charts of a nationally representative sample of patients who were on MMT from May 2008 to December 2013. We selected 10 MMT clinics using probability proportional to size and 50 patients/clinic by systematic random sampling...
March 15, 2018: International Journal on Drug Policy
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