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David D B Bates, Dorathy Tamayo-Murillo, Steven Kussman, Adam Luce, Christina A LeBedis, Jorge A Soto, Stephan W Anderson
PURPOSE: To determine whether the diameter of intrahepatic and extrahepatic bile ducts and pancreatic ducts in patients on methadone maintenance therapy is increased when compared with control subjects. METHODS: Between January 1, 2000 and March 15, 2013, a total of 97 patients (mean age 49.9, range 22-79, 65 male, 32 female) were identified who were receiving chronic methadone maintenance therapy (MMT) when they underwent imaging with abdominal MRI or a contrast-enhanced abdominopelvic CT...
October 21, 2016: Abdominal Radiology
Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci, Fusun Yildiz
BACKGROUND: The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation Syndrome (OHS) patients. METHODS: Ten healthy normal and obese controls, 10 OHS and 10 OSAS patients were included in the study. Short form-36, Beck Depression Scale and State-Trade Anxiety Inventory (STAI 1-2) were performed. Wisconsin Card Sorting Test (WCST), Montreal Cognitive Assessment Scale (MOCA), Enhanced Cued Recall (ECR) and Mini Mental Test (MMT) were used for neurocognitive evaluation...
2016: Multidisciplinary Respiratory Medicine
Joni Bing Fei Teoh, Anne Yee, Mahmoud Danaee, Chong Guan Ng, Ahmad Hatim Bin Sulaiman
OBJECTIVES: Erectile dysfunction (ED) is a problem commonly encountered by patients on methadone maintenance therapy (MMT). This study aimed to assess the prevalence of ED among this group of patients along with its risk factors and association with quality of life (QOL). METHODS: Male patients on MMT in a tertiary hospital in Malaysia were included in the study. A total of 134 patients with sexual partners were assessed for ED using the International Index of Erectile Function...
October 6, 2016: Journal of Addiction Medicine
Orly Sarid, Richard Isralowitz, Mor Yehudai, Alexander Reznik
BACKGROUND: There is a dearth of information about mothers in methadone maintenance treatment (MMT), their parental stress, and suicidal ideation. AIM: To evaluate parenting stress and suicidal ideation among heroin-dependent mothers in MMT. METHOD: The study was conducted at an MMT center. Inclusion criteria were mothers with at least one child between 6-12 years of age. Mothers (n = 41) were interviewed about their background characteristics, drug use, parenting stress, and suicide ideation...
October 12, 2016: Crisis
Benliang Liang, Hewei Zhao, Qi Zhang, Yuzun Fan, Yonghai Yue, Penggang Yin, Lin Guo
Inspired by nacre, this is the first time that using the cross-linking of alginate with Ca ions to fabricate organic-inorganic nacre-inspired films we have successfully prepared a new class of Ca(2+) ion enhanced montmorillonite (MMT)-alginate (ALG) composites, realizing an optimum combination of high strength (∼280 MPa) and high toughness (∼7.2 MJ m(-3)) compared with other MMT based artificial nacre. Furthermore, high temperature performance of the composites (with a maximum strength of ∼170 MPa at 100 °C) along with excellent transmittance, fire retardancy, and unique shape memory response to alcohols could greatly expand the application of the mutilfunctional composites, which are believed to show competitive advantages in transportion, construction, and insulations, protection of a flammable biological material, etc...
October 11, 2016: ACS Applied Materials & Interfaces
Aydin Hassani, Alireza Khataee, Semra Karaca, Canan Karaca, Peyman Gholami
TiO2/Montmorillonite (TiO2/MMT) nanocomposite as sonocatalyst was produced by immobilizing synthesized TiO2 on the surface of montmorillonite. The characteristics of produced nanocomposite were investigated using XRD, XRF, FTIR, TEM, SEM, EDX, UV-vis DRS and nitrogen adsorption-desorption analyses. The synthesized TiO2 and TiO2/MMT samples were applied as catalysts for sonocatalytic degradation of ciprofloxacin (CIP). The performance of the TiO2/MMT was greater than pure TiO2 sample in treatment of CIP solution...
October 1, 2016: Ultrasonics Sonochemistry
Michelle Alvares Sarcinelli, Marta de Souza Albernaz, Marzena Szwed, Alexandre Iscaife, Kátia Ramos Moreira Leite, Mara de Souza Junqueira, Emerson Soares Bernardes, Emerson Oliveira da Silva, Maria Ines Bruno Tavares, Ralph Santos-Oliveira
Monoclonal antibodies as polymeric nanoparticles are quite interesting and endow this new drug category with many advantages, especially by reducing the number of adverse reactions and, in the case of radiopharmaceuticals, also reducing the amount of radiation (dose) administered to the patient. In this study, a nanoradiopharmaceutical was developed using polylactic acid (PLA)/polyvinyl alcohol (PVA)/montmorillonite (MMT)/trastuzumab nanoparticles labeled with technetium-99m (99mTc) for breast cancer imaging...
2016: OncoTargets and Therapy
Li Li, W Scott Comulada, Chunqing Lin, Chiao-Wen Lan, Xiaobin Cao, Zunyou Wu
Provider-client interaction is an integral of clinical practice and central to the delivery of high-quality medical care. This article examines factors related to the provider-client interaction in the context of methadone maintenance treatment (MMT). Data were collected from 68 MMT clinics in China. In total, 418 service providers participated in the survey. Linear mixed effects regression models were performed to identify factors associated with provider-client interaction. It was observed that negative attitude toward drug users was associated with lower level of provider-client interaction and less time spent with each client...
October 6, 2016: Health Communication
Andrew Raines, Mei-Shu Shih, Lorraine Chua, Chen-Wei Su, Scheffer Cg Tseng, Julie O'Connell
Osteoarthritis (OA) is a progressive degenerative joint disease and to date, no disease modifying osteoarthritis drug exist. Amniotic membrane and umbilical cord products have been used clinically in several diseases due to their anti-inflammatory and anti-scarring properties. In the present study, we sought to evaluate whether a particulate amniotic membrane and umbilical cord (AM/UC) matrix could aid in attenuating disease progression. Lewis rats underwent medial meniscus transection (MMT) to induce OA. Two weeks after surgery, animals received intra-articular injections (50 μL) of either 50 µg/µL or 100 µg/µL particulate AM/UC or saline control and were subsequently euthanized 1 or 4 weeks later...
October 5, 2016: Tissue Engineering. Part A
M Eugenia Socías, Evan Wood, Will Small, Huiru Dong, Jean Shoveller, Thomas Kerr, Julio Montaner, M-J Milloy
BACKGROUND: Methadone maintenance therapy (MMT) is associated with improved HIV treatment outcomes among people who use drugs (PWUD). The extent to which these benefits are sustained in the context of ongoing cocaine use is unclear. We assessed differential impacts of MMT on HIV viral load (VL) suppression in relation to discrete patterns of cocaine use. METHODS: Data was drawn from ACCESS, a prospective cohort of HIV-positive PWUD in Vancouver, Canada. Generalized linear mixed-effects were used to model the independent effect of MMT on VL suppression across strata of frequency of cocaine injection and crack smoking (≥daily versus <daily), after adjustment for confounders...
September 20, 2016: Drug and Alcohol Dependence
Cameron Edwin Alexander, Stuart Gowland, Jon Cadwallader, Dave Hopkins, John M Reynard, Benjamin W Turney
PURPOSE: To assess the effectiveness of routine prophylactic antibiotics in the prevention of urinary tract infection (UTI) after SWL, and to identify predictors of UTI development, in a multi-centre series of over 10,000 stone cases treated in New Zealand over a 20 year period. MATERIALS AND METHODS: Patients treated with SWL on the Mobile Medical Technology (MMT) vehicle between 19/06/1995 and 01/12/2014 were identified. Data collection was undertaken prospectively for patient, stone, treatment characteristics and retrospectively for treatment outcomes...
October 4, 2016: Journal of Endourology
Weixiu Li, Ziyun Wang, Zhimin Liu
OBJECTIVES: To investigate factors associated with illicit opioid use among methadone maintenance treatment (MMT) population. METHODS: Participants were recruited from Beijing (2 clinics), Shanghai (2 clinics), Guangdong (2 clinics), Chongqing (2 clinics) and Gansu (1 clinic) provinces. Information about heroin use and MMT was obtained from a self-reported questionnaire, illicit opioid use was obtained from monthly medical records. Binary logistic regression was used to investigate factors associated with illicit opioid use...
October 3, 2016: Environmental Health and Preventive Medicine
Verner S Westerberg, Barbara S McCrady, Mandy Owens, Paul Guerin
Because it is not common in the U.S. for jails to allow inmates to continue opioid medications that have been started in the community, we aimed to assess whether inmates maintained on methadone showed different rates of recidivism, lengths of incarceration, and types of offenses than other incarcerated groups. We also analyzed rates of return to home clinics after release. In order to answer these questions this study used extant data from 960 adult inmates in a large metropolitan detention center who were in 1 of 4 groups: general population with no known substance use disorders, alcohol detoxification, methadone maintenance (MMT), and opioid detoxification...
November 2016: Journal of Substance Abuse Treatment
Yafei Wu, Shiyan Yan, Yanping Bao, Zhi Lian, Zhi Qu, Zhimin Liu
BACKGROUND: Methadone maintenance treatment (MMT) is widely recognized as an effective method of combatting narcotic addiction. MMT reduces heroin withdrawal symptoms and, thus, makes it possible to provide the psychological and social support that is essential to the rehabilitation of drug users. AIM: Compare the severity of depressive symptoms in heroin users who are currently receiving MMT to that of heroin users who are not receiving MMT. METHODS: We administered the 13-item version of the Beck Depression Inventory (BDI-13) and a demographic history form to 929 heroin users who had been receiving MMT at nine methadone treatment clinics in three Chinese cities for an average of 9 months and to 238 heroin users who had enrolled in a MMT program at the centers but had not yet begun MMT...
February 25, 2016: Shanghai Archives of Psychiatry
Zhong Chen, Xiaoying Fu, Jian Kuang, Ju Chen, Hongmei Chen, Jianhao Pei, Huazhang Yang
BACKGROUND: Acarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known. This study aimed to examine the effects of single-dose acarbose on the secretion of incretins in patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: In this pilot study, twenty-three patients diagnosed with T2DM were randomly assigned to the oral glucose tolerance test (OGTT) group (n = 11) and the mixed meal test (MMT) group (n = 12)...
September 29, 2016: BMC Endocrine Disorders
Chunqing Lin, Li Li, Xiaobin Cao
BACKGROUND: Using methadone maintenance therapy (MMT) clinics to deliver antiretroviral therapy (ART) has proven to be effective for promoting treatment initiation and adherence in drug users living with HIV. OBJECTIVES: The objective of this study was to investigate the HIV-positive client acceptability of integrated ART services and to identify the reasons for and factors associated with service acceptability. METHODS: A total of 86 HIV-positive MMT clients were recruited from 12 MMT clinics in Sichuan Province, China...
September 28, 2016: Substance Use & Misuse
Vincent Tiffreau, François Kopciuch, André Thevenon, François Rannou, Eric Hachulla, Philippe Thoumie
OBJECTIVE: To evaluate the medium-term functional impact and effect on quality of life of a standardized rehabilitation programme in patients with polymyositis and dermatomyositis. MATERIALS/PATIENTS AND METHODS: Design: a multicentre, randomized, controlled trial. - Setting: four university hospitals in France. - Participants: 20 patients suffering from polymyositis and dermatomyositis. - Interventions: the intervention group participated in a four-week standardized, hospital-based rehabilitation programme and then a personalized, self-managed, home-based rehabilitation programme...
September 2016: Annals of Physical and Rehabilitation Medicine
Matthew Randesi, Wim van den Brink, Orna Levran, Peter Blanken, Eduardo R Butelman, Vadim Yuferov, Joel Correa da Rosa, Jurg Ott, Jan M van Ree, Mary Jeanne Kreek
BACKGROUND: Heroin addiction is a chronic, relapsing brain disease. Genetic factors are involved in the development of drug addiction. The aim of this study was to determine whether specific variants in genes of the opioid system are associated with non-dependent opioid use and heroin dependence. METHODS: Genetic information from four subject groups was collected: non-dependent opioid users (NOD) [n=163]; opioid-dependent (OD) patients in methadone maintenance treatment (MMT) [n=143]; opioid-dependent MMT-resistant patients in heroin-assisted treatment (HAT) [n=138]; and healthy controls with no history of opioid use (HC) [n=153]...
September 5, 2016: Drug and Alcohol Dependence
Thu Vuong, Marian Shanahan, Nhu Nguyen, Giang Le, Robert Ali, Khue Pham, Thu T A Vuong, Thuy Dinh, Alison Ritter
INTRODUCTION: In Vietnam, two dominant approaches for heroin treatment are center-based compulsory rehabilitation (CCT), funded by the Vietnamese government and community-based voluntary methadone maintenance treatment (MMT), funded primarily by international donors. Recent reduction in international funding requires more efficient allocation of government funding for public health programs. A cost-effectiveness analysis comparing two approaches provides a useful source of evidence to inform the government about funding reallocation...
September 13, 2016: Drug and Alcohol Dependence
Kaina Zhou, Hengxin Li, Xiaoli Wei, Xiaomei Li, Guihua Zhuang
OBJECTIVES: To identify medication adherence and its influencing factors among patients of 14 methadone maintenance treatment (MMT) clinics in Xi'an, China. METHODS: Data were obtained from the National AIDS Information System-Community Methadone Maintenance Treatment. All patients registered in the system were not permitted to take methadone at home without professionals' supervision. Medication adherence was assessed using categorical (ie, dropout or retained) and continuous (ie, treatment time, methadone use time, and percentage of methadone use days) variables...
September 19, 2016: Journal of Addiction Medicine
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