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https://www.readbyqxmd.com/read/29245175/development-and-testing-of-a-hybrid-measure-of-muscle-strength-in-juvenile-dermatomyositis-for-use-in-routine-care
#1
Giulia Camilla Varnier, Silvia Rosina, Cristina Ferrari, Angela Pistorio, Alessandro Consolaro, Francesca Bovis, Sara Dalprà, Clarissa Pilkington, Susan Maillard, Adele Civino, Elena Tsitsami, Jaime de Inocencio, Marija Jelusic, Jelena Vojinovic, Graciela Espada, Balahan Makay, Maria Martha Katsicas, Polixeni Pratsidou-Gertsi, Dragana Lazarevic, Anand Prahalad Rao, Denise Pires Marafon, Nicolino Ruperto, Alberto Martini, Angelo Ravelli
OBJECTIVE: To develop and test a hybrid measure of muscle strength for juvenile dermatomyositis (JDM), which is based on the combination of the Manual Muscle Testing 8 (MMT8) and the Childhood Myositis Assessment Scale (CMAS), but is more comprehensive than the former and more feasible than the latter. METHODS: The hybrid MMT/CMAS (hMC) is composed of all 8 items of the MMT8 and 3 items of the CMAS: 1) time of head lift; 2) assessment of abdominal muscles; 3) floor rise...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29240775/ornithine-decarboxylase-as-a-therapeutic-target-for-endometrial-cancer
#2
Hong Im Kim, Chad R Schultz, Andrea L Buras, Elizabeth Friedman, Alyssa Fedorko, Leigh Seamon, Gadisetti V R Chandramouli, G Larry Maxwell, André S Bachmann, John I Risinger
Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and confirmed this in the cancer genome atlas (TCGA) with highest expression in non-endometrioid, high grade, and copy number high cancers, which have the worst clinical outcomes. ODC1 expression was associated with worse overall survival and increased recurrence in three endometrial cancer gene expression datasets...
2017: PloS One
https://www.readbyqxmd.com/read/29239825/palpebral-portion-of-the-orbicularis-oculi-muscle-to-repetitive-nerve-stimulation-testing-a-potential-assessment-indicator-in-patients-with-generalized-myasthenia-gravis
#3
Chong Yan, Jie Song, Song Pang, Fangfang Yi, Jianying Xi, Lei Zhou, Ding Ding, Weifeng Wang, Kai Qiao, Chongbo Zhao
Repetitive nerve stimulation (RNS) is a valuable diagnostic method for myasthenia gravis (MG). However, its association with clinical severity was scarcely studied. We reviewed medical records and retrospectively enrolled 121 generalized MG patients. Sensitivity of different muscles to RNS and clinical scoring systems was evaluated. RNS testing revealed facial muscles have the highest positive rate, followed by proximal muscles and distal muscles, with the palpebral portion of the orbicularis oculi muscle most sensitive...
November 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29234968/a-cross-national-analysis-of-the-association-between-years-of-implementation-of-opioid-substitution-treatments-and-drug-related-deaths-in-europe-from-1995-to-2013
#4
Phillip L Marotta, Charlotte A McCullagh
Data at the individual-level provide evidence that opioid substitution treatment (OST) programs protect against mortality for opioid dependent populations. Prior research has not examined the merits of national implementation of opioid substitution programs for reducing mortality at the country-level. This study elucidates longitudinal associations between country-level implementation of opioid substitution treatment programs on mortality rates of drug related deaths (DRD) from 1995 to 2013 in 30 European nations...
December 12, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29222992/inflammatory-chemokine-eotaxin-1-is-correlated-with-age-in-heroin-dependent-patients-under-methadone-maintenance-therapy
#5
Hsiang-Wei Kuo, Tung-Hsia Liu, Hsiao-Hui Tsou, Ya-Ting Hsu, Sheng-Chang Wang, Chiu-Ping Fang, Chia-Chen Liu, Andrew C H Chen, Yu-Li Liu
BACKGROUND: Degeneration of central neurons and fibers has been observed in postmortem brains of heroin dependent patients. However, there are no biomarkers to predict the severity of neurodegeneration related to heroin dependence. A correlation has been reported between inflammatory C-C motif chemokine ligand 11 (CCL11, or eotaxin-1) and neurodegeneration in Alzheimer's disease. METHODS: Three-hundred-forty-four heroin dependent, Taiwanese patients under methadone maintenance treatment (MMT) were included with clinical assessment and genomics information...
November 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29216554/active-nanocomposite-films-based-on-soy-proteins-montmorillonite-clove-essential-oil-for-the-preservation-of-refrigerated-bluefin-tuna-thunnus-thynnus-fillets
#6
Ignacio Echeverría, María Elvira López-Caballero, María Carmen Gómez-Guillén, Adriana Noemi Mauri, María Pilar Montero
This manuscript evaluates the potential application of active nanocomposite films based on soy protein isolate (SPI)-montmorillonite (MMT)-clove essential oil (CEO) to the preservation of muscle fillets of bluefin tuna (Thunnus thynnus) during refrigerated storage, and furthermore analyzes whether the clay diffuses from the package to food. SPI films with: CEO (SPI-CEO), MMT (SPI-MMT), or both CEO and MMT (SPI-MMT-CEO), were prepared and used to cover tuna fillets during 17days of storage at 2°C. Polyethylene films were also used as control...
October 2, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29214554/geniposide-suppresses-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-chondrocytes-via-the-pi3k-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Tianlong Pan, Xuchao Shi, Huan Chen, Rong Chen, Dengying Wu, Zeng Lin, Jingdong Zhang, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is principally characterized by progressive joint dysfunction and cartilage degradation. Inflammation and apoptosis play critical roles in the progression of OA. Geniposide (GPO), one of the principal components of the fruit of Gardenia jasminoides Ellis, has been reported to have anti-inflammatory and other pharmacological effects. In this study, we performed in vitro experiments on rat chondrocytes to examine the therapeutic effects of GPO on OA and investigated its effects in vivo in a rat model of OA induced by medial meniscal tear (MMT)...
December 6, 2017: Inflammation
https://www.readbyqxmd.com/read/29211754/testing-the-mindfulness-to-meaning-theory-evidence-for-mindful-positive-emotion-regulation-from-a-reanalysis-of-longitudinal-data
#8
Eric L Garland, Adam W Hanley, Phillipe R Goldin, James J Gross
BACKGROUND AND OBJECTIVE: The Mindfulness to Meaning Theory (MMT) provides a detailed process model of mindful positive emotion regulation. DESIGN: We conducted a post-hoc reanalysis of longitudinal data (N = 107) derived from a RCT of mindfulness-based stress reduction (MBSR) versus cognitive-behavioral therapy (CBT) for social anxiety disorder to model the core constructs of the MMT (attentional control, decentering, broadened awareness, reappraisal, and positive affect) in a multivariate path analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29211298/prognostic-relevance-of-early-radiologic-response-to-induction-chemotherapy-in-pediatric-rhabdomyosarcoma-a-report-from-the-international-society-of-pediatric-oncology-malignant-mesenchymal-tumor-95-study
#9
Bas Vaarwerk, Johanna H van der Lee, Willemijn B Breunis, Daniel Orbach, Julia C Chisholm, Nathalie Cozic, Meriel Jenney, Rick R van Rijn, Kieran McHugh, Soledad Gallego, Heidi Glosli, Christine Devalck, Mark N Gaze, Anna Kelsey, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Veronique Minard-Colin, Johannes H M Merks
BACKGROUND: Early response to induction chemotherapy is used in current European guidelines to evaluate the efficacy of chemotherapy and subsequently to adapt treatment in pediatric patients with rhabdomyosarcoma (RMS). However, existing literature on the prognostic value of early radiologic response on survival is contradictory; here the prognostic value is analyzed with data from the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor 95 (MMT-95) study. METHODS: This study examined 432 Intergroup Rhabdomyosarcoma Study Grouping III (macroscopic residue) patients enrolled in the SIOP MMT-95 study with a response assessment after 3 courses of chemotherapy (a 2-dimensional assessment)...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29206063/age-discrimination-in-out-of-hospital-cardiac-arrest-care-a-case-control-study
#10
Eric Wiel, Christophe Di Pompéo, Nicolas Segal, Gérald Luc, Jean-Baptiste Marc, Carine Vanderstraeten, Carlos El Khoury, Joséphine Escutnaire, Karim Tazarourte, Pierre-Yves Gueugniaud, Hervé Hubert
BACKGROUND: Although some studies have questioned whether cardiopulmonary resuscitation (CPR) in older people could be futile, age is not considered an essential out-of-hospital cardiac arrest (OHCA) prognostic factor. However, in the daily clinical practice of mobile medical teams (MMTs), age seems to be an important factor affecting OHCA care. AIMS: The purpose of this study was to compare OHCA care and outcomes between young patients (<65 years old) and older patients...
December 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29201800/effect-of-different-sedation-regimes-on-cognitive-functions-in-colonoscopy
#11
Perihan Ekmekçi, Gulbanu Erkan, Hakan Yilmaz, Baturay K Kazbek, Ulku C Köksoy, Güler Doganay, Doganay Filiz Tüzüner
Aim: To compare the effects of propofol/remifentanil and meperidine/midazolam on postprocedure cognitive function. Materials and methods: A total of 100 American Society of Anesthesiologists (ASA) score I to III patients undergoing elective colonoscopy were taken into the study and divided into two groups. Exclusion criteria were patient refusal, mini mental test (MMT) <26, The Amsterdam Preoperative Anxiety and Information Scale (APAIS) >10, advanced cardiopulmonary or psychiatric disease, chronic alcohol abuse, morbid obesity, and known allergy to study drugs...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29199209/effect-of-hcl-loading-and-ethanol-concentration-over-hcl-activated-clay-catalysts-for-ethanol-dehydration-to-ethylene
#12
Chadaporn Krutpijit, Bunjerd Jongsomjit
Montmorillonite clay (MMT) is one of materials that can be "green material" due to its environmental safety. In this work, acid-activated MMT catalysts were prepared for the dehydration reaction of ethanol. To be the green process, the reaction with bioethanol was also studied. Ethanol concentrations in feed were varied in the range of 10-99.95 wt%. Moreover, the concentrations of hydrochloric acid activated MMT were investigated in range of 0.05-4 M. From the experiment, it reveals that different acid concentrations to activate MMT affect the catalytic activity of catalysts...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29196486/multiple-and-multidimensional-transitions-from-trainee-to-trained-doctor-a-qualitative-longitudinal-study-in-the-uk
#13
Lisi Gordon, Divya Jindal-Snape, Jill Morrison, Janine Muldoon, Gillian Needham, Sabina Siebert, Charlotte Rees
OBJECTIVES: To explore trainee doctors' experiences of the transition to trained doctor, we answer three questions: (1) What multiple and multidimensional transitions (MMTs) are experienced as participants move from trainee to trained doctor? (2) What facilitates and hinders doctors' successful transition experiences? (3) What is the impact of MMTs on trained doctors? DESIGN: A qualitative longitudinal study underpinned by MMT theory. SETTING: Four training areas (health boards) in the UK...
December 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/29191005/construction-of-high-drug-loading-and-enzymatic-degradable-multilayer-films-for-self-defense-drug-release-and-long-term-biofilm-inhibition
#14
Bailiang Wang, Huihua Liu, Lin Sun, Yingying Jin, Xiaoxu Ding, Lingli Li, Jian Ji, Hao Chen
Bacterial infections and biofilm formation on the surface of implants is an important issue which greatly affect biomedical applications and even cause device failure. Construction of high drug loading systems on the surface and control the drug release on-demand is an efficient way to lower the development of resistant bacteria and biofilm formation. In the present study, (montmorillonite/hyaluronic acid-gentamicin)10 ((MMT/HA-GS)10) organic/inorganic hybrid multilayer films were alternately self-assembled on substrates...
November 30, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29190569/the-effect-of-the-relative-permittivity-on-the-tactoid-formation-in-nanoplatelet-systems-a-combined-computer-simulation-saxs-and-osmotic-pressure-study
#15
Maria Jansson, Axel Thuresson, Tomás S Plivelic, Jan Forsman, Marie Skepö
The structural properties, and the intracrystalline swelling of Na+-, and Ca2+-montmorillonite (Na-, and Ca-mmt) have been investigated as an effect of decreasing the relative permittivity of the solvent, i.e. from water to ethanol (EtOH), utilizing the experimental techniques; small angle X-ray scattering (SAXS) and osmotic pressure measurements. The experimental data were compared with the continuum model, utilizing coarse-grained molecular dynamics bulk simulations, Monte Carlo simulations of two infinite parallel surfaces corresponding to two clay platelets, and the strong coupling theory...
November 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29188848/bacterial-self-defense-antibiotics-release-from-organic-inorganic-hybrid-multilayer-films-for-long-term-anti-adhesion-and-biofilm-inhibition-properties
#16
Qingwen Xu, Xi Li, Yingying Jin, Lin Sun, Xiaoxu Ding, Lin Liang, Lei Wang, Kaihui Nan, Jian Ji, Hao Chen, Bailiang Wang
Implant-associated bacterial infections pose serious medical and financial issues due to the colonization and proliferation of pathogens on the surface of the implant. The as-prepared traditional antibacterial surfaces can neither resist bacterial adhesion nor inhibit the development of biofilm over the long term. Herein, novel (montmorillonite/poly-l-lysine-gentamicin sulfate)8 ((MMT/PLL-GS)8) organic-inorganic hybrid multilayer films were developed to combine enzymatic degradation PLL for on-demand self-defense antibiotics release...
November 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/29179519/sleep-in-lonely-heroin-dependent-patients-receiving-methadone-maintenance-treatment-longer-sleep-latency-shorter-sleep-duration-lower-sleep-efficiency-and-poorer-sleep-quality
#17
Hong-Jie Li, Bao-Liang Zhong, Yan-Min Xu, Jun-Hong Zhu, Jin Lu
Given the socially isolated status of Chinese heroin-dependent patients (HDPs) and the significant association between loneliness and sleep problem in the general population, the impact of loneliness on sleep of HDPs is potentially substantial. The study aimed to test whether loneliness is associated with poor sleep in terms of quantity and quality in a consecutive sample of Chinese HDPs receiving methadone maintenance treatment (MMT). The study participants were 603 HDPs of three MMT clinics in Wuhan, China...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29174792/a-randomized-double-blind-placebo-controlled-trial-of-infliximab-in-refractory-polymyositis-and-dermatomyositis
#18
Adam Schiffenbauer, Megha Garg, Christine Castro, Angelina Pokrovnichka, Galen Joe, Joseph Shrader, Imelda Victoria Cabalar, Sara Faghihi-Kashani, Michael O Harris-Love, Paul H Plotz, Frederick W Miller, Mark Gourley
OBJECTIVE: To investigate in a pilot study the safety and efficacy of infliximab in patients with refractory dermatomyositis (DM) and polymyositis (PM). METHODS: A randomized, double-blind, placebo-controlled trial including subjects with active DM or PM. Participants had stable doses of immunosuppressive medication and prednisone (≤0.5mg/kg/day), and exhibited clinical signs of muscle weakness for at least 4 weeks prior to study entry. Participants received infusions of either placebo or infliximab 5mg/kg at 0, 2, 6, and 14 weeks in blinded manner...
October 16, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29169945/enhanced-antibacterial-effect-of-chitosan-film-using-montmorillonite-cuo-nanocomposite
#19
Afsaneh Nouri, Mohammad Tavakkoli Yaraki, Mohammad Ghorbanpour, Shilpi Agarwal, Vinod Kumar Gupta
Montmorillonite -copper oxide (MMT-CuO) nanocomposites were prepared by a facile and eco-friendly method and introduced into chitosan (Cs) matrix to enhance its optical, mechanical and antibacterial properties. The synthesized composites were characterized using diffuse reflectance spectroscopy (DRS), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and energy dispersive X-ray (EDX) spectroscopy. The antimicrobial activity of MMT-CuO nanocomposites showed more than 99% mortality against two Gram-negative bacterium (E...
November 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29168075/pharmacogenetics-of-methadone-response
#20
REVIEW
Francina Fonseca, Marta Torrens
The efficacy of methadone maintenance treatment (MMT) in opioid use disorder is well established but responses vary. The influence of methadone pharmacodynamics and pharmacokinetics on dose requirements and program outcomes remains controversial despite the increasing number of studies evaluating genetic influences on response to methadone treatment. Furthermore, patients require different doses (usually between 60 and 100 mg/day), and there are no clear data on a plasma concentration associated with treatment success...
November 22, 2017: Molecular Diagnosis & Therapy
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