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https://www.readbyqxmd.com/read/28454044/unintended-impacts-of-regulatory-changes-to-british-columbia-methadone-maintenance-program-on-addiction-and-hiv-related-outcomes-an-interrupted-time-series-analysis
#1
M Eugenia Socías, Evan Wood, Ryan McNeil, Thomas Kerr, Huiru Dong, Jean Shoveller, Julio Montaner, M-J Milloy
BACKGROUND: In February 2014, several regulatory reforms were introduced to the methadone maintenance treatment (MMT) program in British Columbia, Canada, including a switch to a ten-times more concentrated methadone formulation and restrictions in pharmacy delivery services. We evaluated possible unintended effects of these changes on illicit drug use patterns and HIV treatment outcomes among HIV-positive opioid users. METHODS: Data was drawn from ACCESS, a prospective community-recruited cohort of HIV-positive people who use illicit drugs in Vancouver, Canada...
April 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28439756/psychological-distress-among-methadone-maintenance-patients-in-vietnamese-mountainous-areas
#2
Long Hoang Nguyen, Bach Xuan Tran, Huong Lan Thi Nguyen, Cuong Tat Nguyen, Canh Dinh Hoang, Hai Quan Le, Hung Van Nguyen, Huong Thi Le, Tho Dinh Tran, Carl A Latkin, Thuc Minh Thi Vu
We conducted a cross-sectional study in Tuyen Quang Province, a mountainous province in northern Vietnam, to examine rates of psychological distress among 241 patients receiving methadone maintenance treatment (MMT). Using the Kessler psychological distress Scale, we found that approximately one-fourth (26.8%) of respondents suffered from mental health pathologies. Physical health problems, current drug use, and alcohol abuse were found to be associated with mental health problems among the participants. Our findings highlight the high prevalence of psychological distress among MMT patients in northern Vietnam, and the need to integrate mental and physical health care services, as well as behavioral health counseling, into currently existing MMT clinics in this region...
April 24, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28437697/catalytic-polymer-clay-composite-for-enhanced-removal-and-degradation-of-diazinon
#3
Itamar A Shabtai, Yael G Mishael
It is well established that organophosphate pesticides, such as diazinon, pose environmental and health risks. Diazinon is prone to rapid acidic hydrolysis, forming the less toxic compound 2-isopropyl-6-methyl-4-pyrimidinol (IMP). In this study, diazinon surface catalyzed hydrolysis was achieved by its adsorption to a composite, based on protonated poly (4-vinyl-pyridine-co-styrene) (HPVPcoS) and montmorillonite (MMT) clay. The adsorption affinity and kinetics of diazinon to HPVPcoS-MMT were significantly higher than those obtained to the deprotonated PVPcoS-MMT, emphasizing the importance of hydrogen bonding...
April 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28427471/quality-of-life-and-healthcare-service-utilization-among-methadone-maintenance-patients-in-a-mountainous-area-of-northern-vietnam
#4
Long Hoang Nguyen, Lan Huong Thi Nguyen, Victoria L Boggiano, Canh Dinh Hoang, Hung Van Nguyen, Huong Thi Le, Hai Quan Le, Tho Dinh Tran, Bach Xuan Tran, Carl A Latkin, Nabil Zary, Minh Thuc Thi Vu
BACKGROUND: The expansion of methadone maintenance treatment in mountainous areas in still limited and little is known about its health impacts on drug users. This study aimed to examine health-related quality of life (HRQOL) and health care access among patients engaging in methadone maintenance treatment (MMT) in Tuyen Quang, a mountainous province in Vietnam. METHODS: We conducted a cross-sectional survey with 241 patients conveniently recruited in two MMT clinics (Son Duong and Tuyen Quang)...
April 20, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28423977/age-associated-differences-in-motor-output-variability-and-coordination-during-the-simultaneous-dorsiflexion-of-both-feet
#5
Amanda Marchini, Rafael Pereira, Wellington Pedroso, Evangelos Christou, Osmar Pinto Neto
Older adults are more variable than young adults on tasks that demand the simultaneous control of more than one effector, and the difference between age groups may be related to their different capacity of coordinating the force output of the involved effectors. The goal of this study was to determine whether age-associated differences in motor output variability during tasks involving the simultaneous dorsiflexion of two feet can be partially explained by differences in coordination and possibly attenuated by physical training...
April 19, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28421342/selective-retina-therapy-with-automatic-real-time-feedback-controlled-dosimetry-for-chronic-central-serous-chorioretinopathy-in-korean-patients
#6
Young Gun Park, Seungbum Kang, Minhee Kim, Nari Yoo, Young Jung Roh
PURPOSE: To evaluate the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) in the treatment of chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective case series study, 50 eyes of 49 patients with chronic CSC demonstrating focal or diffuse foveal leakages on fundus fluorescein angiography (FFA) were included. Following evaluation of test spots at temporal arcades, SRT (wavelength 527 nm, pulse repetition rate 100 Hz, pulse energy ramp with maximal 15 pulses) with retinal spot diameter of 200 μm was applied to the areas of each leakage observed on fluorescein angiography...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28420822/re-entry-and-related-predictors-among-hiv-infected-clients-receiving-methadone-maintenance-treatment-in-guangdong-province-china
#7
Xiaofeng Luo, Xiao Gong, Peizhen Zhao, Xia Zou, Wen Chen, Li Ling
This study examined the re-entry characteristics and related predictors among HIV-infected methadone maintenance treatment (MMT) clients in Guangdong, China. Data on HIV-infected MMT clients was obtained from the clinic MMT registration system in Guangdong. Of the 653 participants, only 9.0% remained in the MMT program until the end of the study. For the drop-outs, 70.0% returned to MMT at least once by the end of the study. Re-entry was independently associated with marital status (ORnever married = 2.24, 95% CI: 1...
April 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28416396/chitosan-composite-three-dimensional-macrospheric-scaffolds-for-bone-tissue-engineering
#8
Veena Vyas, Tejinder Kaur, Arunachalam Thirugnanam
The present work deals with the fabrication of chitosan composite scaffolds with controllable and predictable internal architecture for bone tissue engineering. Chitosan (CS) based composites were developed by varying montmorillonite (MMT) and hydroxyapatite (HA) combinations to fabricate macrospheric three dimensional (3D) scaffolds by direct agglomeration of the sintered macrospheres. The fabricated CS, CS/MMT, CS/HA and CS/MMT/HA 3D scaffolds were characterized for their physicochemical, biological and mechanical properties...
April 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28415414/bionanocomposite-systems-based-on-montmorillonite-and-biopolymers-for-the-controlled-release-of-olanzapine
#9
Artur S Oliveira, Ana C S Alcântara, Sibele B C Pergher
Olanzapine (OLZ) is a drug that is used in the treatment of schizophrenia and other psychoses, and it belongs to the thienobenzodiazepine class. The OLZ molecule has low solubility decreasing bioavailability, but has high permeability in membrane biological being classified as a Class II drug substance according to the Biopharmaceutics Classification System. It was reported many side effects of administering OLZ orally. So, in order to increase the bioavailability of drug and possibly reducing some of side effects, this paper proposes a new material able to controllably release the drug in the body...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415064/physical-demands-of-multimodal-training-competitions-and-their-relationship-to-measures-of-performance
#10
Andrew R Jagim, Owen Rader, Margaret T Jones, Jonathan M Oliver
Jagim, AR, Rader, O, Jones, MT, and Oliver, JM. Physical demands of multimodal training competitions and their relationship to measures of performance. J Strength Cond Res 31(5): 1212-1220, 2017-The purpose of this study was to identify the physical demands of multimodal training (MMT) competitions and to determine the extent of their relationship to select measures of performance. Eighteen (>1.5 years of strength training experience) men (n = 10) and women (n = 8) (mean ± SD; age: 37.8 ± 10.6 years, height: 172...
May 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28402582/mechanical-and-structural-characterization-of-whey-protein-concentrate-montmorilonite-lycopene-films
#11
Rafaela C Pereira, João de Deus S Carneiro, Odílio B G Assis, Soraia V Borges
BACKGROUND: In the present study, the production and characterization of nanocomposites based on whey protein concentrate (WPC) and montmorilonite (MMT) incorporated of lycopene as functional substance is presented and discussed as an alternative biomaterial for potential use in foodstuff applications. A full factorial design with varying levels of MMT (0 and 20 g.Kg(-1) ) and lycopene (0, 60 and 120 g.Kg(-1) ) was used. Mechanical properties (tensile and puncture tests), thermal stability analysis, FT-IR vibrational spectroscopy and film morphology of the resulting materials were evaluated...
April 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28400314/peg-pe-clay-composite-carriers-for-doxorubicin-effect-of-composite-structure-on-release-cell-interaction-and-cytotoxicity
#12
Hagay Kohay, Can Sarisozen, Rupa Sawant, Aditi Jhaveri, Vladimir P Torchilin, Yael G Mishael
A novel drug delivery system for doxorubicin (DOX), based on organic-inorganic composites was developed. DOX was incorporated in micelles (M-DOX) of polyethylene glycol-phosphatidylethanolamine (PEG-PE) which in turn were adsorbed by the clay, montmorillonite (MMT). The nano-structures of the PEG-PE/MMT composites of LOW and HIGH polymer loadings were characterized by XRD, TGA, FTIR, size (DLS) and zeta measurements. These measurements suggest that for the LOW composite a single layer of polymer intercalates in the clay platelets and the polymer only partially covers the external surface, while for the HIGH composite two layers of polymer intercalate and a bilayer may form on the external surface...
April 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28387913/nivolumab-effectively-inhibit-platinum-resistant-ovarian-cancer-cells-via-induction-of-cell-apoptosis-and-inhibition-of-adam17-expression
#13
L-M Sun, Y-C Liu, W Li, S Liu, H-X Liu, L-W Li, R Ma
OBJECTIVE: Nivolumab is an anti-PD-1 (anti-programmed death-1) monoclonal antibody. It has achieved an overall response rate of 17% in Phase 1 clinical trial for patient with platinum-resistant ovarian cancer (PROC). However, its underlying mechanism has not been fully explored yet. The aim of the study is to investigate the efficiency of nivolumab to inhibit PROC cells and its possible mechanism. MATERIALS AND METHODS: Firstly, methylthiazolyl tetrazolium bromide (MTT) assay was performed to determine the IC50 values of cisplatin in cisplatin-sensitive and cisplatin-resistant ovarian cancer cells...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28385251/multifunctional-colloidal-nanofiber-composites-including-dextran-and-folic-acid-as-electro-active-platforms
#14
Zakir M O Rzayev, Ulviye Bunyatova, Murat Şimșek
This work presents the fabrication and characterization of novel colloidal multifunctional polymer nanofiber composites (NFCs) from water dispersion blends of intercalated silicate layered nanocomposites of poly (2-vinyl-N-pyrrolidone)/octadecyl amine-montmorillonite (ODA-MMT) and dextran/ODA-MMT as matrix and partner polymer intercalated nanocomposites in the presence of NaOH and folic acid (FA) as doping agents by green reactive electrospinning. Chemical and physical structures, surface morphology and electrical properties were investigated...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28381321/the-impact-of-total-immunoglobulin-e-levels-on-outcomes-of-maximal-medical-therapy-for-chronic-rhinosinusitis
#15
Ana M Lemos-Rodriguez, Zainab Farzal, Satyan B Sreenath, Brian D Thorp, Brent A Senior, Adam M Zanation, Charles S Ebert
INTRODUCTION: The goal of this project was to evaluate the impact of immunoglobulin E (IgE) levels on outcomes in patients with chronic rhinosinusitis (CRS) who received maximal medical therapy (MMT). STUDY DESIGN: Prospective cohort study. METHODS: Thirty-eight patients who underwent MMT for CRS were assigned to three different cohorts based on their IgE levels: low IgE (<25 IU), moderate (>25 to <149 IU), and high (≥150 IU). The primary outcome evaluated was MMT failure with a surgical recommendation within each IgE cohort...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28376741/neck-circumference-to-inter-incisor-gap-ratio-a-new-predictor-of-difficult-laryngoscopy-in-cervical-spondylosis-patients
#16
Yong-Zheng Han, Yang Tian, Mao Xu, Cheng Ni, Min Li, Jun Wang, Xiang-Yang Guo
BACKGROUND: Preoperative airway assessment help anticipate a difficult airway. We hypothesized that a close association existed between difficult laryngoscopy and the neck circumference/inter-incisor gap ratio (RNIIG). Our aim was to determine its utility in predicting difficult laryngoscopy in cervical spondylosis patients. METHODS: Two hundred thirteen consecutive patients, aged 20-70 years, scheduled to undergo cervical spine surgery under general anesthesia, were recruited...
April 4, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28367308/association-between-cannabis-use-and-methadone-maintenance-treatment-outcomes-an-investigation-into-sex-differences
#17
Laura Zielinski, Meha Bhatt, Nitika Sanger, Carolyn Plater, Andrew Worster, Michael Varenbut, Jeff Daiter, Guillaume Pare, David C Marsh, Dipika Desai, James MacKillop, Meir Steiner, Stephanie McDermid Vaz, Lehana Thabane, Zainab Samaan
BACKGROUND: Cannabis will soon become legalized in Canada, and it is currently unclear how this will impact public health. Methadone maintenance treatment (MMT) is the most common pharmacological treatment for opioid use disorder (OUD), and despite its documented effectiveness, a large number of patients respond poorly and experience relapse to illicit opioids. Some studies implicate cannabis use as a risk factor for poor MMT response. Although it is well established that substance-use behaviors differ by sex, few of these studies have considered sex as a potential moderator...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28363929/tobacco-and-alcohol-use-among-drug-users-receiving-methadone-maintenance-treatment-a-cross-sectional-study-in-a-rural-prefecture-of-yunnan-province-southwest-china
#18
Song Duan, Ziyi Jin, Xing Liu, Yuecheng Yang, Runhua Ye, Renhai Tang, Meiyang Gao, Yingying Ding, Na He
OBJECTIVE: To estimate the prevalence of ever, current and heavy tobacco and alcohol use and their correlates among patients undergoing methadone maintenance treatment (MMT). DESIGN: Cross-sectional study. SETTING: The study was conducted in all of the 5 MMT clinics in Dehong Prefecture, China. PARTICIPANTS: 2121 (81.6%) eligible MMT participants were included in the study population. ANALYSIS: Ordinal logistic regression was used to estimate the ORs and their 95% CIs...
March 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28358908/pharmacogenomics-study-on-cadherin-2-network-with-regard-to-hiv-infection-and-methadone-treatment-outcome
#19
Hsiang-Wei Kuo, Chia-Lung Shih, Jieh-Hen Tsung, Sheng-Wen Liu, Shih-Kai Chu, Hsin-Chou Yang, Hsiao-Hui Tsou, Zih-Hsiang Wang, Andrew C H Chen, Yu-Li Liu
Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may be involved with HIV infection and MMT treatment outcome. Cadherin 2 (CDH2) genetic determinants were identified through the genome-wide pharmacogenomic study...
2017: PloS One
https://www.readbyqxmd.com/read/28347350/the-association-between-age-of-onset-of-opioid-use-and-comorbidity-among-opioid-dependent-patients-receiving-methadone-maintenance-therapy
#20
Leen Naji, Brittany Burns Dennis, Monica Bawor, Michael Varenbut, Jeff Daiter, Carolyn Plater, Guillaume Pare, David C Marsh, Andrew Worster, Dipika Desai, James MacKillop, Lehana Thabane, Zainab Samaan
BACKGROUND: Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this association may inform clinical practice about important prognostic factors of patients on MMT, enabling clinicians to identify high-risk patients. METHODS: This study includes data collected between June 2011 and August 2016 for the Genetics of Opioid Addiction research collaborative between McMaster University and the Canadian Addiction Treatment Centers...
March 28, 2017: Addiction Science & Clinical Practice
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