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Sheng Zhou, Eleonora Cella, Wang Zhou, Wen-Hua Kong, Man-Qing Liu, Pu-Lin Liu, Massimo Ciccozzi, Marco Salemi, Xin-Guang Chen
The extensive genetic heterogeneity of hepatitis C virus (HCV) requires in-depth understanding of the population dynamics of different viral subtypes for more effective control of epidemic outbreaks. We analyzed HCV sequences data from 125 participants in Wuhan, China. These participants were newly infected by subtype 1b (n=13), 3a (n=15), 3b (n=50), and 6a (n=39) while on methadone maintenance treatment (MMT). Bayesian phylogenies and demographic histories were inferred for these subtypes. Participants infected with HCV-1b and 3a were clustered in well-supported monophyletic clades, indicating local sub-epidemics...
January 16, 2017: Journal of Viral Hepatitis
Zalina Zahari, Muslih Abdulkarim Inrahim, Soo Choon Tan, Nasir Mohamad, Rusli Ismail
BACKGROUND/AIM: Sleep disturbances may contribute to poor treatment outcomes in opioid-dependent patients. The extent to which the sleep profiles of opioid-dependent patients differ from those of the general Malaysian population is not documented. This study compared opioid-naive subjects and opioid-dependent patients on methadone maintenance therapy (MMT) in terms of their sleep quality. MATERIALS AND METHODS: Participants comprised Malay male opioid-naive subjects (n = 159) and opioid-dependent patients (n = 160) from MMT clinics in Kelantan, Malaysia, between March and October 2013...
December 20, 2016: Turkish Journal of Medical Sciences
Thu Vuong, Nhu Nguyen, Giang Le, Marian Shanahan, Robert Ali, Alison Ritter
BACKGROUND: In Vietnam, like many countries in Southeast Asia, the commonly used approach of center-based compulsory drug treatment (CCT) has been criticized on human rights ground. Meanwhile, community-based voluntary methadone maintenance treatment (MMT) has been implemented for nearly a decade with promising results. Reform-minded leaders have been seeking empirical evidence of the costs and effectiveness associated with these two main treatment modalities. Conducting evaluations of these treatments, especially where randomization is not ethical, presents challenges...
January 11, 2017: Harm Reduction Journal
Meng-Chang Tsai, Tiao-Lai Huang
Brain-derived neurotrophic factor (BDNF) and oxidative stress may play a role in patients with heroin dependence. The aim of this study was to investigate the serum levels and activities of BDNF and oxidative stress markers, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC), and 8-hydroxy 2'-deoxyguanosine (8-OHdG), in heroin-dependent patients undergoing methadone maintenance treatment (MMT). 60 heroin-dependent male MMT patients and 30 healthy males were recruited for this study...
December 27, 2016: Psychiatry Research
Jennifer N Felder, Barbara Laraia, Kimberly Coleman-Phox, Nicole Bush, Madhuvanthi Suresh, Melanie Thomas, Nancy Adler, Elissa Epel, Aric A Prather
OBJECTIVE/BACKGROUND: Poor sleep quality is common in pregnancy and associated with increased psychological distress, which has adverse consequences for families. Emerging theory suggests that mindfulness-based interventions may help reduce cognitive and emotional reactivity to stressful events. The current study examines the effects of a mindfulness-based intervention on the relationship between poor sleep quality and increased depression symptom severity and perceived stress during pregnancy...
January 6, 2017: Behavioral Sleep Medicine
Hung Van Nguyen, Huong Lan Thi Nguyen, Hue Thi Mai, Hai Quan Le, Bach Xuan Tran, Canh Dinh Hoang, Huong Thi Le, Cuong Tat Nguyen, Tho Dinh Tran, Carl A Latkin, Thuc Minh Thi Vu
BACKGROUND: Stigma and discrimination may adversely affect the benefits of methadone maintenance treatment (MMT) for drug users, especially in disadvantaged settings. This study assessed stigma and discrimination against MMT patients in the mountainous and rural areas in Vietnam and explored their associated factors to inform implementation strategies. METHODS: We interviewed 241 MMT patients in two clinics: one in Tuyen Quang Province's inner city and the other in Son Duong District, to assess stigma and discrimination that patients perceived and experienced...
January 6, 2017: Harm Reduction Journal
Christoph Neuwirth, Paul E Barkhaus, Christian Burkhardt, José Castro, David Czell, Mamede de Carvalho, Sanjeev Nandedkar, Erik Stålberg, Markus Weber
OBJECTIVE: Motor Unit Number Index (MUNIX) is a quantitative neurophysiological measure that provides an index of the number of lower motor neurons supplying a muscle. It reflects the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS). However, it is unclear whether MUNIX also detects motor unit loss in strong, non-wasted muscles. METHODS: Three centres measured MUNIX in 49 ALS patients every three months in six different muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis, abductor hallucis) on the less affected side...
December 18, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Kui Yu, Tonghe Zhu, Yu Wu, Xiangxiang Zhou, Xingxing Yang, Juan Wang, Jun Fang, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo
A dual drug-loaded system is a promising alternative for the sustained drug release system and skin tissue engineering. In this study, a natural sodium montmorillonite (Na-MMT) modified by cetyl trimethyl ammonium bromide (CTAB) was prepared as a carrier to load a model drug - amoxicillin (AMX), the modified organic montmorillonite (CTAB-OMMT) loaded with AMX was marked as AMX@CTAB-OMMT and was subsequently incorporated into poly(ester-urethane) urea (PEUU) and gelatin hybrid nanofibers via electrospinning, resulting in a new drug-loaded nanofibrous scaffold (AMX@CTAB-OMMT-PU75)...
December 23, 2016: Colloids and Surfaces. B, Biointerfaces
Jia Ling Tan, Nicole Maree Thomas, Leanne Marie Johnston
AIMS: Examine the inter-rater reliability of the Daniels and Worthingham (D&W) manual muscle test (MMT) protocol for children with spina bifida between experienced and novice physiotherapists. METHODS: Thirteen children with spina bifida (two males) aged 6 to 18 years were recruited from a spina bifida service in a state-wide tertiary children's hospital. Each child had the muscle strength of 19, and lower limb muscles were measured bilaterally by one experienced and one novice physiotherapist using the D&W MMT protocol...
December 27, 2016: Physical & Occupational Therapy in Pediatrics
Qing Qing, Qi Guo, Linlin Zhou, Yilun Wan, Youqing Xu, Huilong Ji, Xiaohang Gao, Yue Zhang
Catalytic conversion of corncob pretreatment hydrolysate and raw corncob into furfural in a modified biphasic system by SO4(2-)/SnO2(-) MMT solid catalyst has been developed. The influence of the organic solvent type, organic to water phase ratio, sodium chloride concentration, reaction temperature and time on the furfural production were comparatively evaluated. The results showed that furfural yields of 81.7% and 66.1% were achieved at 190°C for 15mins and 190°C for 20mins, respectively, for corncob pretreatment hydrolysate and raw corncob by this solid catalyst...
December 2, 2016: Bioresource Technology
Jhon A Fiscal-Ladino, Mónica Obando-Ceballos, Milton Rosero-Moreano, Diego F Montaño, Wilson Cardona, Luis F Giraldo, Pablo Richter
Montmorillonite (MMT) clays were modified by the intercalation into their galleries of ionic liquids (IL) based on imidazolium quaternary ammonium salts. This new eco-materials exhibited good features for use as a sorptive phase in the extraction of low-polarity analytes from aqueous samples. Spectroscopic analyses of the modified clays were conducted and revealed an increase in the basal spacing and a shifting of the reflection plane towards lower values as a consequence of the effective intercalation of organic cations into the MMT structure...
February 8, 2017: Analytica Chimica Acta
Hussain Fida, Gaoke Zhang, Sheng Guo, Abdul Naeem
The La-Fe montmorillonite (La-Fe MMT) composite was synthesized by a simple precipitation method and was used for the degradation of dyes in both batch and fixed bed experiments. X-ray diffraction (XRD) and high-resolution transmission electron microscope analysis (HRTEM) confirmed the existence of Fe2O3 and La2O3 in the composite. The presence of La enhanced the degradation efficiency of dyes by the composite at neutral pH and results in little iron leaching consequently increasing the lifetime. More than 97% and 96% removal of the MB and RhB (100mg/L each) by the La-Fe MMT Fenton system could be achieved in less than 1h...
March 15, 2017: Journal of Colloid and Interface Science
Yixuan Song, David A Hagen, Shuang Qin, Kevin M Holder, Kyle Falke, Jaime C Grunlan
Layer-by-layer (LbL) assembled polymer-clay multilayer thin films are known to provide transparent and flexible gas barrier. In an effort to further lower the oxygen transmission rate (OTR) of these nanobrick wall thin films, sodium chloride was introduced into montmorillonite (MMT) suspension as an "indifferent electrolyte". At pH 6.5 the amphoteric edge sites of MMT have a neutral net charge, and a moderate concentration of NaCl effectively shields the charge from neighboring platelets, allowing van der Waals forces to attract the edges to one another...
December 21, 2016: ACS Applied Materials & Interfaces
Joan Trujols, Francisco González-Saiz, María José Manresa, Saul Alcaraz, Francesca Batlle, Santiago Duran-Sindreu, José Pérez de Los Cobos
OBJECTIVE: In clinical practice, methadone maintenance treatment (MMT) entails tailoring the methadone dose to the patient's specific needs, thereby individualizing treatment. The aim of this study was to identify the independent factors that may significantly explain methadone dose adequacy from the patient's perspective. METHOD: Secondary analysis of data collected in a treatment satisfaction survey carried out among a representative sample of MMT patients (n=122) from the region of La Rioja (Spain)...
December 12, 2016: Patient Education and Counseling
Yan Zhao, Mingjie Zhang, Cynthia X Shi, Jie Huang, Fujie Zhang, Keming Rou, Zunyou Wu
OBJECTIVE: HIV-infected people who inject drugs (PWID) have a disproportionally low rate of access to antiretroviral therapy (ART). We aimed to assess the impact of ART on 12-month mortality and virological failure of HIV-infected PWID in China, stratified by methadone maintenance treatment (MMT) and active drug use status. METHODS: HIV-infected PWID who initiated ART at 29 clinics in 2011 were enrolled and followed in this prospective cohort study. Kaplan-Meier curves and log-rank tests were used to compare the survival probability...
January 1, 2017: Drug and Alcohol Dependence
Joel Hellrup, Michael Holmboe, Karol P Nartowski, Yaroslav Z Khimyak, Denny Mahlin
This study aims at investigating the molecular level organization and molecular mobility in montmorillonite nanocomposites with the uncharged organic low-molecular-weight compound lactose commonly used in pharmaceutical drug delivery, food technology, and flavoring. Nanocomposites were prepared under slow and fast drying conditions, attained by drying at ambient conditions and by spray-drying, respectively. A detailed structural investigation was performed with modulated differential scanning calorimetry, powder X-ray diffraction, solid-state nuclear magnetic resonance spectroscopy, scanning electron microscopy, microcalorimetry, and molecular dynamics simulations...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Guofeng Li, Kecheng Quan, Yuping Liang, Tianyi Li, Qipeng Yuan, Lei Tao, Qian Xie, Xing Wang
Montmorillonite (MMT) is considered to be the most effective hemostat among natural phyllosilicates. However, there is a barrier against using MMT for the commercial hemostatics because the invaded MMT powders might cause thrombosis in vessel. Until now, it is still a challenge to manage the release of MMT and eliminate its side effect. Herein, we present a graphene-MMT composite sponge (GMCS), synthesized under a hydrothermal reaction, fixing MMT powders into the cross-linked graphene sheets. We demonstrate that only a few embedded MMT can evoke remarkable platelet stimulation at the sponge interface, while maintaining fast plasma absorbency of the innate sponge...
December 28, 2016: ACS Applied Materials & Interfaces
Minfeng Zeng, Yudong Wang, Qi Liu, Xia Yuan, Shufeng Zuo, Ruokun Feng, Jing Yang, Baoyi Wang, Chenze Qi, Yao Lin
Metal nanoparticles, once supported by a suitable scaffolding material, can be used as highly efficient heterogeneous catalysts for numerous organic reactions. The challenge, though, is to mitigate the continuous loss of metals from the supporting materials as reactions proceed, so that the catalysts can be recycled multiple times. Herein, we combine the excellent chelating property of chitosan (CS) and remarkable stability of montmorillonite (MMT) into a composite material to support metal catalysts such as palladium (Pd)...
December 7, 2016: ACS Applied Materials & Interfaces
Hiroaki Nakashima, Shiro Imagama, Hideki Yagi, Fumihiko Kato, Tokumi Kanemura, Koji Sato, Noriaki Kawakami, Mitsuhiro Kamiya, Hisatake Yoshihara, Kenyu Ito, Yukihiro Matsuyama, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: Retrospective multicenter case-controlled study OBJECTIVE.: The aim of this study was to investigate the clinical and radiographical differences between thoracic idiopathic spinal cord herniation (ISCH) and spinal arachnoid cyst (SAC). SUMMARY AND BACKGROUND DATA: ISCH and SAC are relatively rare diseases. Preoperative misdiagnose was frequently reported in both, however these clinical and radiographical differences remain unclear. METHODS: Out of 30,469 patients who underwent spinal surgery, 18 (0...
December 6, 2016: Spine
S Lupinacci, G Toteda, D Vizza, A Perri, C Benincasa, A Mollica, A La Russa, P Gigliotti, F Leone, D Lofaro, M Bonofiglio, E Perri, R Bonofiglio
During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive thickening and angiogenesis of the peritoneal membrane associated with PD. In this study we tested, in vitro and in vivo, the ability of active compounds extracted from extra virgin olive oil (AC-EVOO) to counteract the mesothelial-to-mesenchymal transition process (MMT) observed in mesothelial cells chronically exposed to the conventional peritoneal dialysate (DL)...
December 2, 2016: Journal of Nephrology
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