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https://www.readbyqxmd.com/read/28727956/increasing-availability-of-benzodiazepines-among-people-who-inject-drugs-in-a-canadian-setting
#1
Geoffrey Walton, Huiru Dong, M J Milloy, Kora DeBeck, Thomas Kerr, Evan Wood, Kanna Hayashi
BACKGROUND: Benzodiazepine misuse is associated with mortality and is common among people who inject drugs (PWID). This study aimed to examine the temporal trends in the availability of benzodiazepines among PWID in a Canadian setting, and to identify factors associated with more immediate access to benzodiazepines. METHODS: Data were derived from three prospective cohorts of PWID in Vancouver, Canada, between June 2012 and May 2015. The primary outcome was the perceived availability of benzodiazepines, measured in three levels: not available, delayed availability (available in ≥10 min), and immediate availability (available in <10 min)...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28727077/excess-of-dietary-montmorillonite-impairs-growth-performance-liver-function-and-antioxidant-capacity-in-starter-pigs
#2
H Y Zhao, X B Mao, B Yu, J He, P Zheng, J Yu, J Q Luo, Q Y Wang, D W Chen
Montmorillonite (MMT) is widely used as a mycotoxin adsorbent in animal feeds, but its safety remains unclear. This study was conducted to investigate the safety of MMT supplementation in diets fed to starter pigs. A total of 120 32-d-old piglets (initial weight, 8.0 ± 0.9 kg) were randomly allotted into dietary treatments with graded MMT levels (0 [FS 0], 0.5% [FS 0.5], 1.0% [FS 1.0], 2.5% [FS 2.5], and 5.0% [FS 5.0]) with 6 replicate pens per treatment and 4 pigs per pen. All diets were fed for 28 d. As the MMT level increased, ADG and G:F changed in a linear and quadratic manner, while ADFI was linearly decreased ( > 0...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28716791/factors-associated-with-nicotine-dependence-during-methadone-maintenance-treatment-findings-from-a-multisite-survey-in-vietnam
#3
Huyen Phuc Do, Long Hoang Nguyen, Nhung Phuong Thi Nguyen, Chau Ngo, Huong Lan Thi Nguyen, Giang Tong Le, Linh Khanh Nguyen, Cuong Tat Nguyen, Bach Xuan Tran, Huong Thi Le, Thuc Minh Thi Vu, Huong Thu Thi Phan, Tho Dinh Tran, Carl A Latkin, Michael P Dunne
OBJECTIVES: Smoking is associated with adverse health outcomes among drug users, including those in treatment. To date, however, there has been little evidence about smoking patterns among people receiving opioid-dependence treatment in developing countries. We examined self-reported nicotine dependence and associated factors in a large sample of opioid-dependent patients receiving methadone maintenance treatment (MMT) in northern Vietnam. SETTING: Five clinics in Hanoi (urban area) and Nam Dinh (rural area)...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28716045/barriers-to-accessing-and-using-health-insurance-cards-among-methadone-maintenance-treatment-patients-in-northern-vietnam
#4
Bach Xuan Tran, Victoria L Boggiano, Cuong Tat Nguyen, Long Hoang Nguyen, Anh Tuan Le Nguyen, Carl A Latkin
BACKGROUND: Methadone maintenance treatment (MMT) patients face unique costs associated with their healthcare expenditures. As such, it is important that these patients have access to health insurance (HI) to help them pay for both routine and unforeseen health services. In this study, we explored factors related to health insurance enrollment and utilization among MMT patients, to move Vietnam closer to universal coverage among this patient population. METHODS: A cross-sectional study was conducted with 1003 patients enrolled in MMT in five clinics in Hanoi and Nam Dinh provinces...
July 17, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28715236/effects-of-different-heel-raise-lower-exercise-interventions-on-the-strength-of-plantarflexion-balance-and-gait-parameters-in-stroke-survivors
#5
Seung-Mi Lee, Heon-Seock Cynn, Tae-Lim Yoon, Ji-Hyun Lee
The objective of this study was to investigate the effects of Heel-Raise-Lower Exercise (HRLE) interventions on the strength of plantarflexion, balance, and gait parameters in people with stroke. Specifically, this study compared the two different HRLEs to identify whether heels raise-lower with forefoot on a block (HRB) is more effective or ineffective to enhance strength and functional capacities than heels raise-lower on a level floor (HRL) exercise in people with stroke. Repetitive heel raise-lower is a common exercise for improving the strength and power of ankle plantarflexors...
July 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28710214/trends-and-factors-in-human-immunodeficiency-virus-and-or-hepatitis-c-virus-testing-and-infection-among-injection-drug-users-newly-entering-methadone-maintenance-treatment-in-guangdong-province-china-2006-2013-a-consecutive-cross-sectional-study
#6
Yin Liu, Yu Liu, Xia Zou, Wen Chen, Li Ling
OBJECTIVES: To assess trends and related factors in HIV and/or hepatitis C virus (HCV) antibody testing and infection among injection drug users (IDUs) newly entering methadone maintenance treatment (MMT) in Guangdong Province, China. METHOD: Consecutive cross sectional surveys were conducted in 14 MMT clinics from July 2006 to December 2013 in Guangdong Province, China. IDUs were excluded if they were re-enrolled or referred from other MMT clinics. Trend tests were used to examine HIV and/or HCV testing and infection, sociodemographic characteristics, drug use related behaviours and the past 3 month sexual behaviours on enrolment...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28707481/protective-effects-of-melatonin-and-memantine-in-human-retinal-pigment-epithelium-arpe-19-cells-against-2-ethylpyridine-induced-oxidative-stress-implications-for-age-related-macular-degeneration
#7
Handan Bardak, Abdülhadi Cihangir Uğuz, Yavuz Bardak
PURPOSE: To investigate the possible protective effects of melatonin and memantine (MMT) against 2-ethylpyridine (2-EP)-induced oxidative stress and mitochondrial dysfunction in human RPE (ARPE-19) cells in vitro. MATERIALS AND METHODS: The ARPE-19 cells were divided into seven groups. Oxidative stress was triggered by incubating the ARPE-19 cells with 30 µM of 2-EP for 24 hours. Then, 200 µM of melatonin was administered over three days and 20 µM of MMT over six hours prior to the experiment...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28704148/-i-was-not-sick-and-i-didn-t-need-to-recover-methadone-maintenance-treatment-mmt-as-a-refuge-from-criminalization
#8
David Frank
BACKGROUND: Methadone Maintenance Treatment (MMT) in the United States (U.S.) has been undergoing a shift towards conceptualizing the program as recovery-based treatment. Although recovery is seen by some as a means to restore MMT to its rightful position as a medically-based treatment for addiction, it may not represent the experiences, or meet the needs of people who use drugs (PWUD), many of whom who use the program as a pragmatic means of reducing harms associated with criminalization...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28704128/commune-health-workers-methadone-maintenance-treatment-mmt-knowledge-and-perceived-difficulties-providing-decentralized-mmt-services-in-vietnam
#9
Chunqing Lin, Nguyen Anh Tuan, Li Li
BACKGROUND: With the initial establishment of countrywide methadone maintenance therapy (MMT) system, Vietnam is in the process of expanding and decentralizing the MMT program to community-based healthcare settings. OBJECTIVE: The study aimed to measure the MMT-related knowledge and perceived difficulties in treating patient who use drugs (PWUD) among community-based healthcare providers, e.g., commune health workers (CHW), and examine its correlated factors. METHODS: A total of 300 CHW from 60 communes in two provinces of Vietnam completed a survey using Audio Computer-Assisted Self-Interview (ACASI) method...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28701208/expanding-co-payment-for-methadone-maintenance-services-in-vietnam-the-importance-of-addressing-health-and-socioeconomic-inequalities
#10
Bach Xuan Tran, Quyen Le Nguyen, Long Hoang Nguyen, Huong Thu Thi Phan, Huong Thi Le, Tho Dinh Tran, Thuc Thi Minh Vu, Carl A Latkin
BACKGROUND: Ensuring high enrollment while mobilizing resources through co-payment services is critical to the success of the methadone maintenance treatment (MMT) program in Vietnam. This study assessed the willingness of patients to pay (WTP) for different MMT services delivery models and determined its associated factors. METHODS: A facility based survey was conducted among 1016 MMT patients (98.7% male, 42% aged 35 or less, and 67% living with spouse) in five MMT clinics in Hanoi and Nam Dinh province in 2013...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28699698/reduced-dosing-and-liability-in-methadone-maintenance-treatment-by-targeting-oestrogen-signal-for-morphine-addiction
#11
Yao-Chang Chiang, Ruey-Yun Wang, Chieh-Liang Huang, Shue-Hwa Chen, Wen-Jing Ho, Hsien-Yuan Lane, Ing-Kang Ho, Hwei-Ting Yang, Wen-Lung Ma
Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen-response element single nucleotide polymorphism (ERE-SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated with high MMT dosing, high enantiomer (R- or S-) of 2-ethylidene-1,5-dimethyl-3,3-dipheny-pyrrolidine (EDDP; methadone metabolite) to methadone ratio and increased drug-seeking behaviour, implicating oestradiol-CYP-EDDP/methadone axis decreasing MMT efficacy...
July 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28685566/thermochromic-artificial-nacre-based-on-montmorillonite
#12
Jingsong Peng, Yiren Cheng, Antoni P Tomsia, Lei Jiang, Qunfeng Cheng
Nacre-inspired nanocomposites have attracted a great deal of attention in recent years because of their special mechanical properties and universality of the underlying principles of materials engineering. The ability to respond to external stimuli will augment the high toughness and high strength of artificial nacre-like composites and open new technological horizons for these materials. Herein, we fabricated robust artificial nacre based on montmorillonite (MMT) that combines robustness with reversible thermochromism...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28677813/anticancer-and-apoptosis%C3%A2-inducing-effects-of-quercetin-in-vitro-and-in-vivo
#13
Mahmoud Hashemzaei, Amin Delarami Far, Arezoo Yari, Reza Entezari Heravi, Kaveh Tabrizian, Seyed Mohammad Taghdisi, Sarvenaz Ekhtiari Sadegh, Konstantinos Tsarouhas, Dimitrios Kouretas, George Tzanakakis, Dragana Nikitovic, Nikita Yurevich Anisimov, Demetrios A Spandidos, Aristides M Tsatsakis, Ramin Rezaee
The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT‑26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor‑positive breast cancer MCF‑7 cells, acute lymphoblastic leukemia MOLT‑4 T‑cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells)...
June 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28676206/manganese-testing-under-a-clean-air-act-test-rule-and-the-application-of-resultant-data-in-risk-assessments
#14
Darcie Smith, George M Woodall, Annie M Jarabek, William K Boyes
In the 1990's, the proposed use of methylcyclopentadienyl manganese tricarbonyl (MMT) as an octane-enhancing gasoline fuel additive led to concerns for potential public health consequences from exposure to manganese (Mn) combustion products in automotive exhaust. After a series of regulatory/legal actions and negotiations, the U.S. Environmental Protection Agency (EPA) issued under Clean Air Act (CAA) section 211(b) an Alternative Tier 2 Test Rule that required development of scientific information intended to help resolve uncertainties in exposure or health risk estimates associated with MMT use...
July 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28675869/flame-retardant-and-hydrophobic-coatings-on-cotton-fabrics-via-sol-gel-and-self-assembly-techniques
#15
Dongqiao Zhang, Brandon L Williams, Saral B Shrestha, Zain Nasir, Elaina M Becher, Benjamin J Lofink, Victor H Santos, Harsh Patel, Xiaohong Peng, Luyi Sun
Nanocoatings consisting of ammonium polyphosphate (APP), sodium montmorillonite (MMT), and vinyltrimethoxysilane (VTMS) were prepared via self-assembly and in situ sol-gel techniques and applied onto cotton fabrics to achieve both flame retardancy and hydrophobicity. The impacts of APP concentration on the hydrophobicity and fire resistance of the coated fabrics were investigated. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) characterization results verified the hydrolysis-condensation reaction of VTMS and the formation of Si-O-Si network structure...
June 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28660107/optimal-timing-of-surgery-for-intramedullary-cavernous-hemangioma-of-the-spinal-cord-in-relation-to-preoperative-motor-paresis-disease-duration-and-tumor-volume-and-location
#16
Shiro Imagama, Zenya Ito, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Yoshimoto Ishikawa, Akiyuki Matsumoto, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Hiroaki Nakashima, Norimitsu Wakao, Yoshihito Sakai, Yukihiro Matsuyama, Naoki Ishiguro
STUDY DESIGN: Prospective study. OBJECTIVE: Investigate factors associated with preoperative motor paresis, recovery, ambulatory status, and intraoperative neurophysiological monitoring (IONM) among patients with no preoperative paresis (N group), complete preoperative motor recovery (CR group), and no complete recovery (NCR group) in patients with intramedullary spinal cavernous hemangioma to determine the optimal timing of surgery. METHODS: The study evaluated 41 surgical cases in our institute...
May 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28652072/evaluation-of-a-hepatitis-c-education-intervention-with-clients-enrolled-in-methadone-maintenance-and-needle-syringe-programs-in-malaysia
#17
Trena I Mukherjee, Veena Pillai, Siti Hafizah Ali, Frederick L Altice, Adeeba Kamarulzaman, Jeffrey A Wickersham
BACKGROUND: Approximately 40%-90% of people who inject drugs (PWID) in Malaysia have hepatitis C (HCV). PWID continue to be disproportionately affected by HCV due to their lack of knowledge, perceived risk and interest in HCV treatment. Education interventions may be an effective strategy for increasing HCV knowledge in PWID, and harm reduction services are uniquely positioned to implement and deploy such interventions. METHODS: We recruited 176 clients from methadone maintenance treatment (MMT: N=110) and needle/syringe programs (NSP: N=66) between November 2015 and August 2016...
June 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28651618/relationships-between-received-and-perceived-social-support-and-health-related-quality-of-life-among-patients-receiving-methadone-maintenance-treatment-in-mainland-china
#18
Kaina Zhou, Hengxin Li, Xiaoli Wei, Juan Yin, Peifeng Liang, Hongmei Zhang, Lingling Kou, Mengmeng Hao, Lijuan You, Xiaomei Li, Guihua Zhuang
BACKGROUND: Social support has been considered one of the most important factors of health-related quality of life (HRQoL) evaluations among different populations; however, few studies have explored the relationships of both received and perceived social support to HRQoL among patients undergoing methadone maintenance treatment (MMT). Thus, the purpose of this cross-sectional study was to clarify these relationships. METHODS: Participants were patients admitted at the two largest privately and publicly funded MMT clinics in Xi'an...
June 26, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28642082/clinical-trial-of-the-effects-of-vitamin-d-supplementation-on-psychological-symptoms-and-metabolic-profiles-in-maintenance-methadone-treatment-patients
#19
Amir Ghaderi, Hamid Reza Banafshe, Maryam Motmaen, Morad Rasouli-Azad, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: Vitamin D deficiency may be associated with some complications including nonspecific musculoskeletal pain and periodontal disease in maintenance methadone treatment (MMT) patients. This study was designed to determine the effect of vitamin D supplementation on psychological symptoms and metabolic profiles in MMT patients. METHODS: This randomized, double-blind, placebo-controlled, clinical trial was carried out among 68 MMT patients. Participants were randomly allocated to receive either 50,000IU vitamin D supplements (n=34) or placebo (n=34) every 2weeks for 12weeks...
June 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28641929/initiation-and-engagement-with-methadone-treatment-among-pregnant-and-postpartum-women
#20
Kristin M Mattocks, Robin Clark, Linda Weinreb
PURPOSE: The purpose of this study was to explore perceptions of experiences and challenges with methadone maintenance treatment (MMT) and obstetrical care among pregnant and postpartum women enrolled in a methadone maintenance program. RESEARCH DESIGN: The study featured a grounded theory approach including two focus groups with pregnant and postpartum methadone users at a methadone maintenance clinic in Worcester, Massachusetts. Two research team members conducted and recorded focus groups, which took approximately 45 minutes to 1 hour...
June 19, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
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