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https://www.readbyqxmd.com/read/29786925/computed-tomographic-and-radiographic-bronchial-collapse-may-be-a-normal-characteristic-of-forced-expiration-in-dogs
#1
Hyunryung Kim, Young Joo Kim, Hanbin Lee, Taegeon An, Jin Yu, Hyounglok Yoon, Gayeon An, Jaihyun Jung, Jinhwa Chang, Dongwoo Chang
Tracheobronchomalacia has been diagnosed using radiography or bronchoscopy to confirm bronchial changes in luminal diameter during the respiratory cycle. However, studies in healthy humans suggest that some degree of bronchial collapse may be observed during the normal respiratory cycle. In this analytical study, the luminal diameter of the bronchus to each of the six pulmonary lobes and the mean percentage of expiratory collapse from end inspiratory, end expiratory, and two forced expiratory phases (10 and 15 ml/kg) were determined via computed tomography (CT) and radiography in 22 healthy Beagle dogs...
May 22, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29786637/dog-theft-a-case-for-tougher-sentencing-legislation
#2
REVIEW
Lauren K Harris
Dogs, and other companion animals, are currently classed as "property" in theft sentencing legislation for England and Wales. This means that offenders who steal dogs are given similar sentences to those that steal inanimate objects. This review presents the argument that the penalty for dog theft should be more severe than for the theft of non-living property. Evidence of the unique bond between dogs and humans, and discussion of the implications of labelling a living being as mere "property" are used to support this argument...
May 22, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29786524/veterinary-herd-health-management-experience-among-farmers-and-farm-managers-in-swedish-dairy-production
#3
C Svensson, K Alvåsen, A C Eldh, J Frössling, H Lomander
A preventive herd health approach will most likely reduce incidences of clinical and subclinical disease. Swedish veterinary organizations offer specific veterinary herd health management (HHM) programs, but these services are not used to a large extent. The aim of this study was to investigate dairy farmers' experience of HHM and the conditions for collaboration with veterinarians in HHM. Six focus group discussions were conducted in March 2015 in West Sweden. In total, 33 dairy farmers participated. The recordings were transcribed and coded using thematic analysis, and the transcripts were reviewed to identify potential factors indicating barriers for farmers to engage a veterinarian in HHM...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786522/a-survey-of-experiences-of-uk-cattle-and-sheep-farmers-with-anthelmintic-prescribers-are-best-practice-principles-being-deployed-at-farm-level
#4
Easton Stephanie, L Pinchbeck Gina, J Bartley David, E Hodgkinson Jane, B Matthews Jacqueline
Helminths are common pathogens of ruminants. These are controlled by anthelmintics; however, resistance is a major issue. More sustainable practices need to be deployed to protect anthelmintic efficacy. There is no published information on how farmer/prescriber interactions at anthelmintic purchase shape application of best practice on-farm. To determine experiences of UK ruminant farmers as they relate to anthelmintic purchasing/provision of best practice advice at the point-of-sale, an online survey was distributed...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786154/topical-polyhydroxy-acid-treatment-for-autosomal-recessive-congenital-ichthyosis-in-the-golden-retriever-a-prospective-pilot-study
#5
Anna Puigdemont, Nicla Furiani, Michela De Lucia, Isaac Carrasco, Laura Ordeix, Dolors Fondevila, Laura Ramió-Lluch, Pilar Brazis
BACKGROUND: Autosomal recessive congenital ichthyosis (ARCI) in golden retrievers is due to a PNPLA1 gene mutation, which plays a role in epidermal lipid organization and metabolism. Topical therapies are used to reduce scaling; however, there are few published efficacy studies. OBJECTIVES: To examine the efficacy of topical treatment based on gluconolactone, a polyhydroxy acid with known beneficial effects on stratum corneum structure. ANIMALS: Sixteen golden retriever dogs with clinical signs of ARCI and PCR-confirmed PNPLA1 gene mutation...
May 22, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29785931/first-bone-cracking-dog-coprolites-provide-new-insight-into-bone-consumption-in-borophagus-and-their-unique-ecological-niche
#6
Xiaoming Wang, Stuart C White, Mairin Balisi, Jacob Biewer, Julia Sankey, Dennis Garber, Z Jack Tseng
Borophagine canids have long been hypothesized to be North American ecological 'avatars' of living hyenas in Africa and Asia, but direct fossil evidence of hyena-like bone consumption is hitherto unknown. We report rare coprolites (fossilized feces) of Borophagus parvus from the late Miocene of California and, for the first time, describe unambiguous evidence that these predatory canids ingested large amounts of bone. Surface morphology, micro-CT analyses, and contextual information reveal (1) droppings in concentrations signifying scent-marking behavior, similar to latrines used by living social carnivorans; (2) routine consumption of skeletons; (3) undissolved bones inside coprolites indicating gastrointestinal similarity to modern striped and brown hyenas; (4) B...
May 22, 2018: ELife
https://www.readbyqxmd.com/read/29785924/preliminary-evidence-for-the-absence-of-cystic-echinococcosis-in-gabon-a-cross-sectional-pilot-survey-in-humans-and-definitive-hosts
#7
Felix Lötsch, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Mirjam Groger, Luzia Veletzky, Ayôla Akim Adegnika, Bertrand Lell, Selidji Todagbe Agnandji, Marielle Bouyou-Akotet, Markus Obermüller, Marion Wassermann, Renate Schneider, Herbert Auer, Michael Ramharter
Cystic echinococcosis (CE) is a globally endemic zoonosis caused by the larval stage of the Echinococcus granulosus sensu lato (s.l.) complex. Although the disease is known to be highly prevalent in certain parts of North and East Africa, data on CE, both in humans and definitive hosts, are extremely scarce for Central Africa. The present study assessed the epidemiology of CE in humans and dogs in rural Gabon. An ultrasound and serologic survey was conducted in volunteers from rural villages in Gabon. A two-step approach was used for serological testing with an indirect hemagglutination assay as a screening test and Western Blot as a confirmatory test...
May 21, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29785833/species-differences-in-bile-acids-i-plasma-and-urine-bile-acid-composition
#8
Rhishikesh Thakare, Jawaher Abdullah Alamoudi, Nagsen Gautam, A David Rodrigues, Yazen Alnouti
Maintenance of bile acid (BA) homeostasis is essential to achieve their physiologic functions and avoid their toxic effects. The marked differences in BA composition between preclinical safety models and humans may play a major role in the poor prediction of drug-induced liver injury using preclinical models. We compared the composition of plasma and urinary BAs and their metabolites between humans and several animal species. Total BA pools and their composition varied widely among different species. Highest sulfation of BAs was observed in human and chimpanzee...
May 21, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29785754/expression-of-zo-1-and-claudin-1-in-a-3d-epidermal-equivalent-using-canine-progenitor-epidermal-keratinocytes
#9
Keiji Teramoto, Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Sadatoshi Maeda
BACKGROUND: Previous studies indicate that tight junctions are involved in the pathogenesis of canine atopic dermatitis (cAD). An in vitro skin model is needed to elucidate the specific role of tight junctions in cAD. A 3D epidermal equivalent model using canine progenitor epidermal keratinocytes (CPEK) has been established; the expression of tight junctions within this model is uncharacterized. HYPOTHESIS/OBJECTIVES: To investigate the expression of tight junctions in the 3D epidermal equivalent...
May 21, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29785086/the-utilization-of-an-ocular-wound-chamber-on-corneal-epithelial-wounds
#10
Jennifer S McDaniel, Andrew W Holt, Elaine D Por, Elof Eriksson, Anthony J Johnson, Gina L Griffith
Purpose: Currently available ocular moisture chambers are not adequate to manage the treatment of periocular burns, corneal injuries, and infection. The purpose of these studies was to demonstrate that a flexible, semi-transparent ocular wound chamber device adapted from technology currently used on dermal wounds is safe for use on corneal epithelial injuries. Materials and methods: A depilatory cream (Nair™, 30 seconds) was utilized to remove the excess hair surrounding the left eyes of anesthetized Institute Armand Frappier (IAF) hairless, female guinea pigs (Crl:HA-Hrhr)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29784410/part-3-solid-phase-extraction-of-russian-vx-and-its-chemical-attribution-signatures-in-food-matrices-and-their-detection-by-gc-ms-and-lc-ms
#11
Audrey M Williams, Alexander K Vu, Brian P Mayer, Saphon Hok, Carlos A Valdez, Armando Alcaraz
Chemical attribution signatures indicative of O-isobutyl S-(2-diethylaminoethyl) methylphosphonothioate (Russian VX) synthetic routes were investigated in spiked food samples. Attribution signatures were identified using a multifaceted approach: Russian VX was synthesized using six synthetic routes and the chemical attribution signatures identified by GC-MS and LC-MS. Three synthetic routes were then down selected and spiked into complex matrices: bottled water, baby food, milk, liquid eggs, and hot dogs. Sampling and extraction methodologies were developed for these materials and used to isolate the attribution signatures and Russian VX from each matrix...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784408/part-2-forensic-attribution-profiling-of-russian-vx-in-food-using-liquid-chromatography-mass-spectrometry
#12
Daniel Jansson, Susanne Wiklund Lindström, Rikard Norlin, Saphon Hok, Carlos A Valdez, Audrey M Williams, Armando Alcaraz, Calle Nilsson, Crister Åstot
This work is part two of a three-part series in this issue of a Sweden-United States collaborative effort towards the understanding of the chemical attribution signatures of Russian VX (VR) in synthesized samples and complex food matrices. In this study, we describe the sourcing of VR present in food based on chemical analysis of attribution signatures by liquid chromatography-tandem mass spectrometry (LC-MS/MS) combined with multivariate data analysis. Analytical data was acquired from seven different foods spiked with VR batches that were synthesized via six different routes in two separate laboratories...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784391/exploiting-the-synergistic-effect-of-concurrent-data-signals-low-level-fusion-of-liquid-chromatographic-with-dual-detection-data
#13
Carla M Teglia, Silvana M Azcarate, Mirta R Alcaráz, Héctor C Goicoechea, María J Culzoni
A low-level data fusion strategy was developed and implemented for data processing of second-order liquid chromatographic data with dual detection, i.e. absorbance and fluorescence monitoring. The synergistic effect of coupling individual information provided by two different detectors was evaluated by analyzing the results gathered after the application of a series of data preprocessing steps and chemometric resolution. The chemometric modeling involved data analysis by MCR-ALS, PARAFAC and N-PLS. Their ability to handle the new data block was assessed through the estimation of the analytical figures of merits achieved in the prediction of a validation set containing fifteen fluorescent and non-fluorescent veterinary active ingredients that can be found in poultry litter...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784076/analgesic-efficacy-and-hematologic-effects-of-robenacoxib-in-mice
#14
Jennifer A Beninson, Jennifer L Lofgren, Patrick A Lester, Madeline M Hileman, Daniel J Berkowitz, Daniel D Myers
NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics used to treat postoperative pain. We evaluated robenacoxib, a NSAID highly selective for cyclooxygenase 2, in a carrageenan paw edema (CPE) assay and surgical model of venous thrombosis (VT). We generated a mouse-specific dose-response curve by using the CPE assay for robenacoxib doses of 3...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784055/usefulness-of-c-reactive-protein-and-serum-amyloid-a-in-early-detection-of-postoperative-infectious-complications-to-tibial-plateau-leveling-osteotomy-in-dogs
#15
Karin Löfqvist, Mads Kjelgaard-Hansen, Michelle Brønniche Møller Nielsen
BACKGROUND: Cranial cruciate ligament rupture is a prevalent injury in dogs, and tibial plateau leveling osteotomy (TPLO) is one of the preferred surgical techniques. Surgical site infection is a possible complication following TPLO and measurement of serum acute phase proteins is suggested to be a way to early recognize and distinguish postoperative infectious complications from normal postoperative inflammatory conditions. In this study we investigate the changes in concentrations of the systemic inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) following tibial plateau leveling osteotomy (TPLO) in dogs and evaluate if deviations from the changes expectedly induced by the surgical procedure are useful in early detection of post-surgical infections...
May 21, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29784034/comparison-of-three-imaging-modalities-used-to-evaluate-bone-healing-after-tibial-tuberosity-advancement-in-cranial-cruciate-ligament-deficient-dogs-and-comparison-of-the-effect-of-a-gelatinous-matrix-and-a-demineralized-bone-matrix-mix-on-bone-healing-a-pilot
#16
Marije Risselada, Matthew D Winter, Daniel D Lewis, Emily Griffith, Antonio Pozzi
BACKGROUND: Bone healing and assessment of the state of bone bridging is an important part of clinical orthopedics, whether for fracture healing or for follow up of osteotomy procedures. Tibial tuberosity advancement (TTA) is designed to restore stability in cruciate deficient stifle joints by advancing the tuberosity while creating an osteotomy gap. The current study aims to: 1) compare three different imaging modalities to assess bone healing: ultrasound, radiographs and computed tomography (CT) and, to 2) compare the effect of a gelatinous matrix (GM) versus a demineralized bone matrix mix (DBM mix) on bone healing and bridging of this osteotomy gap in 10 otherwise healthy client-owned dogs with cranial cruciate ligament insufficiency...
May 22, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29783993/cirsimaritin-inhibits-influenza-a-virus-replication-by-downregulating-the-nf-%C3%AE%C2%BAb-signal-transduction-pathway
#17
Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li
BACKGROUND: Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains. Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported. Thus, the aim of this study is to investigate the anti-influenza virus efficacy and antiviral mechanism of CST. METHODS: The inhibitory activity of CST against influenza viruses was assessed by using viral titers and performing Western blot, qRT-PCR, and immunofluorescence assays in Madin-Darby canine kidney (MDCK) cells and a human monocytic cell line (THP-1)...
May 21, 2018: Virology Journal
https://www.readbyqxmd.com/read/29783632/effects-of-dietary-arginine-ornithine-and-zeolite-supplementation-on-uremic-toxins-in-cats
#18
Nadine Paßlack, Jürgen Zentek
To test if arginine and ornithine, both components of the Krebs-Henseleit cycle, or zeolite, a potential ammonium absorber, can modulate the excretion of harmful bacterial metabolites, intestinal microbial protein fermentation was stimulated by feeding a high-protein (60.3%) diet as a single daily meal to 10 adult cats. The diet was supplemented without or with arginine (+50, 75, 100% compared to arginine in the basal diet), ornithine (+100, 150, 200% compared to arginine in the basal diet), or zeolite (0.125, 0...
May 18, 2018: Toxins
https://www.readbyqxmd.com/read/29783120/canine-mesenchymal-stem-cells-treated-with-tnf-%C3%AE-and-ifn-%C3%AE-enhance-anti-inflammatory-effects-through-the-cox-2-pge-2-pathway
#19
Hye-Mi Yang, Woo-Jin Song, Qiang Li, Su-Yeon Kim, Hyeon-Jin Kim, Min-Ok Ryu, Jin-Ok Ahn, Hwa-Young Youn
Mesenchymal stem cells (MSCs) have been used in studies on treatment of various diseases, and their application to immune-mediated diseases has garnered interest. Various methods for enhancing the immunomodulation effect of human MSCs have been used; however, similar approaches for canine MSCs are relatively unexplored. Accordingly, we evaluated immunomodulatory effects and mechanisms in canine MSCs treated with TNF-α and IFN-γ. Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were incubated with the conditioned media (CM) from canine MSCs for 48 h...
May 14, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29783107/effect-of-cd-on-growth-physiological-response-cd-subcellular-distribution-and-chemical-forms-of-koelreuteria-paniculata
#20
Lan Peng Yang, Jian Zhu, Ping Wang, Jing Zeng, Rong Tan, Yu Zhong Yang, Zhi Ming Liu
Koelreuteria paniculata were cultivated in nutrient solution with different concentrations of Cd (0, 50, 150, 250 and 500 µM) and sampled after 90 days. The resistance, translocation, accumulation and stress responses in Koelreuteria paniculata were investigated by hydroponic experiments. The results showed that Koelreuteria paniculata is an efficient Cd excluder that can tolerate high concentrations of Cd (up to 150-250 µM of Cd). The concentration of Cd never exceeds 5 ppm in leaves and 10 ppm in roots...
May 18, 2018: Ecotoxicology and Environmental Safety
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