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https://www.readbyqxmd.com/read/29156859/relationship-of-paratracheal-lymph-nodes-with-the-progression-of-chronic-autoimmune-thyroiditis-5-year-follow-up-results
#1
Gülhan Akbaba, Dilek Berker, Serhat Işık, Narin Nasıroğlu İmga, Ferit Kerim Küçükler, Yasemin Tütüncü, Serdar Güler
Background/aim: To examine changes in paratracheal lymph nodes (PLNs) and the relationship with the course of the disease in patients with chronic autoimmune thyroiditis (CAT) 5 years after diagnosis. Materials and methods: A total of 169 patients with newly diagnosed CAT and 53 healthy subjects were included in the study. All patients underwent ultrasonographic (US) examinations of the thyroid, paratracheal regions, and examined thyroid function tests. Eighty-four patients who were euthyroid at baseline and who were contacted 5 years after the diagnosis were reevaluated by US and thyroid function tests...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156583/new-paradigms-for-the-study-of-ocular-alphaherpesvirus-infections-insights-into-the-use-of-non-traditional-host-model-systems
#2
REVIEW
Matthew R Pennington, Eric C Ledbetter, Gerlinde R Van de Walle
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HSV-1 ocular infections in humans, suggesting that infection of dogs and cats with CHV-1 and FHV-1, respectively, can be used as a comparative natural host model of herpesvirus-induced ocular disease. In this review, we discuss both strengths and limitations of the various available model systems to study ocular herpesvirus infection, with a focus on the use of these non-traditional virus-natural host models...
November 18, 2017: Viruses
https://www.readbyqxmd.com/read/29156435/more-than-a-to-b-understanding-and-managing-visitor-spatial-behaviour-in-urban-forests-using-public-participation-gis
#3
Silviya Korpilo, Tarmo Virtanen, Tiina Saukkonen, Susanna Lehvävirta
Planning and management needs up-to-date, easily-obtainable and accurate information on the spatial and social aspects of visitor behaviour in order to balance human use and impacts, and protection of natural resources in public parks. We used a web-based public participation GIS (PPGIS) approach to gather citizen data on visitor behaviour in Helsinki's Central Park in order to aid collaborative spatial decision-making. The study combined smartphone GPS tracking, route drawing and a questionnaire to examine differences between user groups in their use of formal trails, off-trail behaviour and the motivations that affect it...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156343/native-and-exotic-oysters-in-brazil-comparative-tolerance-to-hypercapnia
#4
Anthony Moreira, Etelvina Figueira, Iracy L Pecora, Amadeu M V M Soares, Rosa Freitas
Environmental hypercapnia in shallow coastal marine ecosystems can be exacerbated by increasing levels of atmospheric CO2. In these ecosystems organisms are expected to become increasingly subjected to pCO2 levels several times higher than those inhabiting ocean waters (e.g.: 10,000µatm), but still our current understanding on different species capacity to respond to such levels of hypercapnia is limited. Oysters are among the most important foundation species inhabiting these coastal ecosystems, although natural oyster banks are increasingly threatened worldwide...
November 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29156336/magnesium-lithospermate-b-loaded-pegylated-solid-lipid-nanoparticles-for-improved-oral-bioavailability
#5
Xuqi Kang, Hui Chen, Shujuan Li, Liyong Jie, Jingbo Hu, Xiaojuan Wang, Jing Qi, Xiaoying Ying, Yongzhong Du
Magnesium lithospermate B (MLB) is an active polyphenol acid with multiple pharmacological activities and poor oral bioavailability. The present research aimed to construct MLB loaded solid lipid nanoparticles (MLB-SLNs) for oral delivery to enhance its bioavailability. MLB-SLNs were prepared by solvent diffusion method and subsequently modified with polyethylene glycol monostearate (PEG-SA) superficially. The particle sizes of MLB-SLNs varied from 82.57 to 53.50nm with an improved drug loading capacity (up to 16...
November 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29156308/modulatory-effects-of-green-tea-extract-against-the-hepatotoxic-effects-of-4-nonylphenol-in-catfish-clarias-gariepinus
#6
A H Sayed, Hamdy A M Soliman
The antioxidant role of the green tea (Camellia sinensis) extract (GTE) was examined to remedy the toxic effects of (0.2mgl(-1)) 4-nonylphenol(4-NP). Biochemical parameters, antioxidant enzymes, liver lipid peroxidation (LPO), DNA fragmentation, and apoptosis as well as histopathology of liver of African catfish Clarias gariepinus were considered. Catfishes were divided into four groups: first group (control), second group (0.2mgl(-1) of 4-NP), third group (0.2mgl(-1)of 4-NP +100mg GTE l(-1)water), and fourth group (0...
November 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29156079/the-gard-platform-for-potency-assessment-of-skin-sensitizing-chemicals
#7
Kathrin S Zeller, Andy Forreryd, Tim Lindberg, Robin Gradin, Aakash Chawade, Malin Lindstedt
Contact allergy induced by certain chemicals is a common health concern, and several alternative methods have been developed to fulfill the requirements of European legislation with regard to hazard assessment of potential skin sensitizers. However, validated methods, which provide information about the potency of skin sensitizers, are still lacking. The cell-based assay Genomic Allergen Rapid Detection (GARD), targeting key event 3, dendritic cell activation, of the skin sensitization AOP, uses gene expression profiling and a machine learning approach for the prediction of chemicals as sensitizers or non-sensitizers...
2017: ALTEX
https://www.readbyqxmd.com/read/29156063/traumatic-ruptured-globe-from-a-22-cartridge-casing-in-a-2-year-old-girl
#8
Jacob S Martin, Devasis N Reddy, Heather A D Potter, Cat N Burkat
The authors report the case of a 2-year-old girl who presented with an acute ruptured globe secondary to penetration by the casing of a .22 caliber cartridge that was ignited by a car cigarette lighter. Although penetrating injuries are a common mechanism of ocular trauma, open globe induced by cartridge casing represents an unusual and preventable cause. [J Pediatr Ophthalmol Strabismus. 2017;54:e88-e90.].
November 17, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29155975/induced-cortical-responses-require-developmental-sensory-experience
#9
Prasandhya Astagiri Yusuf, Peter Hubka, Jochen Tillein, Andrej Kral
Sensory areas of the cerebral cortex integrate the sensory inputs with the ongoing activity. We studied how complete absence of auditory experience affects this process in a higher mammal model of complete sensory deprivation, the congenitally deaf cat. Cortical responses were elicited by intracochlear electric stimulation using cochlear implants in adult hearing controls and deaf cats. Additionally, in hearing controls, acoustic stimuli were used to assess the effect of stimulus mode (electric versus acoustic) on the cortical responses...
November 16, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29155877/immune-response-profiles-of-calves-following-vaccination-with-live-bcg-and-inactivated-mycobacterium-bovis-vaccine-candidates
#10
E M D L van der Heijden, J Chileshe, J C M Vernooij, C Gortazar, R A Juste, I Sevilla, J E Crafford, V P M G Rutten, A L Michel
Conventional control and eradication strategies for bovine tuberculosis (BTB) face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations...
2017: PloS One
https://www.readbyqxmd.com/read/29155872/sulfur-dioxide-alleviates-programmed-cell-death-in-barley-aleurone-by-acting-as-an-antioxidant
#11
Sha-Sha Wang, Ying-Xin Zhang, Feng Yang, Zhong-Qin Huang, Jun Tang, Kang-Di Hu, Hua Zhang
Sulfur dioxide (SO2), a gaseous signaling molecule in animal cells, has recently been found to play a physiological role in plants. Here we studied the role of SO2 in gibberellic acid (GA3)-induced programmed cell death (PCD) in barley (Hordeum vulgare L.) aleurone layers. The application of the SO2 donor (NaHSO3/Na2SO3, 1:3 M/M) effectively alleviated PCD in barley aleurone layers in a dose-dependent manner with an optimal concentration of 50 μM. Further investigations showed that SO2 reduced the accumulation of hydrogen peroxide (H2O2), superoxide anion (⋅O2-) and malondialdehyde (MDA) in aleurone layers...
2017: PloS One
https://www.readbyqxmd.com/read/29155863/molecular-detection-of-tick-borne-pathogens-in-cattle-from-southwestern-ethiopia
#12
Zerihun Hailemariam, Jürgen Krücken, Maximilian Baumann, Jabbar S Ahmed, Peter-Henning Clausen, Ard M Nijhof
Tick-borne diseases (TBDs) cause significant losses among livestock and impact the livelihoods of resource-poor farming communities worldwide. In Ethiopia, detailed studies on the epidemiology of tick-borne pathogens (TBPs) in cattle using sensitive molecular detection methods are scarce. The objective of this study was to determine the prevalence and species composition of bovine TBPs of veterinary significance in local cattle populations. A comprehensive cross-sectional epidemiological study was conducted in cattle populations of Illubabor zone in Southwestern Ethiopia from June to August 2013...
2017: PloS One
https://www.readbyqxmd.com/read/29155829/environmental-and-socio-demographic-individual-family-and-neighborhood-factors-associated-with-children-intestinal-parasitoses-at-iguaz%C3%A3%C2%BA-in-the-subtropical-northern-border-of-argentina
#13
Maria Romina Rivero, Carlos De Angelo, Pablo Nuñez, Martín Salas, Carlos E Motta, Alicia Chiaretta, Oscar D Salomón, Song Liang
BACKGROUND: Intestinal parasitoses are a major concern for public health, especially in children from middle and low-income populations of tropical and subtropical areas. We examined the presence and co-infection of parasites in humans as well as parasitic environmental contamination in Puerto Iguazú, Argentina. We explored the environmental and socio-demographic characteristics of the persistence of parasites in children and their environment. METHODOLOGY/PRINCIPAL FINDINGS: This cross-section survey was conducted among children population comprised into the area of the public health care centers of Iguazú during June 2013 to May 2016...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155788/use-of-synaptic-zinc-histochemistry-to-reveal-different-regions-and-laminae-in-the-developing-and-adult-brain
#14
Reem Khalil, Jonathan B Levitt
Characterization of anatomical and functional brain organization and development requires accurate identification of distinct neural circuits and regions in the immature and adult brain. Here we describe a zinc histochemical staining procedure that reveals differences in staining patterns among different layers and brain regions. Others have utilized this procedure not only to reveal the distribution of zinc-containing neurons and circuits in the brain, but also to successfully delineate areal and laminar boundaries in the developing and adult brain in several species...
October 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155568/discovery-of-a-novel-series-of-tankyrase-inhibitors-by-a-hybridization-approach
#15
Upendra Rao Anumala, Jo Waaler, Yves Nkizinkiko, Alexander Ignatev, Katina Lazarow, Peter Lindemann, Petter Angell Olsen, Sudarshan Murthy, Ezeogo Obaji, Alexander G Majouga, Sergey V Leonov, Jens Peter von Kries, Lari Lehtiö, Stefan Krauss, Marc Nazaré
A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on tankyrase 1 and 2 with a biochemical and cellular IC50 values of 29 nM, 6.3 nM and 19 nM, respectively, and high selectivity towards other Poly(ADP-ribose) polymerase enzymes. The identified inhibitor shows a favorable in-vitro ADME profile as well as good oral bioavailability in mice, rats and dogs. Critical for the approach was the utilization of an appropriate linker between 1,2,4-triazole and benzimidazolone moieties, whereby a cyclobutyl linker displayed superior affinity compared to a cyclohexane and phenyl linker...
November 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29155282/seizure-liability-assessments-using-the-hippocampal-tissue-slice-comparison-of-non-clinical-species
#16
Michael V Accardi, Hai Huang, Simon Authier
INTRODUCTION: Traditionally, rat hippocampal tissue slice models are used as an in vitro electrophysiology assay to assess seizurogenic potential in early drug development despite non-clinical species-specific differences noted during in vivo seizure studies. METHODS: Hippocampal tissue slices were acutely isolated from rats, minipigs, dogs and nonhuman primates (NHP). Population spikes (PS) were evoked through stimulation of the CA3 Schaffer collateral pathway and recorded using in vitro electrophysiological techniques via an extracellular electrode placed within the CA1 stratum pyramidale cell body layer...
November 16, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29155261/the-phosphodiesterase-4-inhibitor-fcpr16-attenuates-ischemia-reperfusion-injury-in-rats-subjected-to-middle-cerebral-artery-occlusion-and-reperfusion
#17
Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Yufang Cheng, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng, Jiangping Xu
Current phosphodiesterase-4 (PDE4) inhibitors exert beneficial effects in central nervous system diseases via anti-inflammatory and anti-apoptotic properties, but many of them are plagued by side effects like nausea and emesis. FCPR16, a novel PDE4 inhibitor synthesized in our lab, has potential anti-inflammatory property. In the present study, we aimed to investigate the effects of FCPR16 in a rat model of ischemic stroke and evaluate its emetogenic potential. Our results showed that FCPR16 treatment improved neurological function, reduced cerebral infarct volume, and attenuated brain histological changes in rats subjected to middle cerebral artery occlusion and reperfusion (MCAO/R)...
November 16, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29155017/p-glycoprotein-mdr1-abcb1-and-breast-cancer-resistance-protein-bcrp-abcg2-affect-brain-accumulation-and-intestinal-disposition-of-encorafenib-in-mice
#18
Jing Wang, Changpei Gan, Rolf W Sparidans, Els Wagenaar, Stéphanie van Hoppe, Jos H Beijnen, Alfred H Schinkel
Encorafenib (LGX818) is a promising BRAF(V600E) inhibitor that has efficacy against metastatic melanoma. To better understand its pharmacokinetics, we studied its interactions with the multidrug efflux transporters ABCB1 and ABCG2 and the multidrug metabolizing enzyme CYP3A. In polarized MDCK-II cells, encorafenib was efficiently transported by canine and human ABCB1 and ABCG2 and by mouse Abcg2. Upon oral administration to wild-type, Abcb1a/1b(-/-), Abcg2(-/-), and Abcb1a/1b;Abcg2(-/-) mice, encorafenib was absorbed very quickly and to very high plasma levels, but without clear changes in oral availability between the strains...
November 14, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29154928/sequence-analysis-of-the-thrombospondin-related-adhesive-protein-gene-and-heat-shock-protein-70-of-babesia-gibsoni-isolated-from-dogs-in-nanjing-china
#19
Huan-Ran Lin, Xiao-Ting Mei, Yu-Fang Hong, Yan-Bing Zhao, Xiao-Nan Guo, De-Ji Yang, Da-Wei Yao
In this study, the thrombospondin-related adhesive protein (TRAP) gene and the heat shock protein 70 (Hsp70) gene of Babesia gibsoni isolated from the naturally infected dog in the Nanjing area were cloned and sequenced. Twenty blood samples were collected from the suspected cases of babesiosis at the animal hospital of Nanjing Agriculture University. Genomic DNA was extracted from the blood samples, and the 18S rDNAs were amplified by PCR to confirm Babesia infection. As a result, 10 cases of Babesia 18S rDNA gene amplification were positive in the 20 blood samples, confirming that the 10 cases were infected with canine Babesia...
November 14, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29154712/prognosis-for-dogs-with-stage-iii-osteosarcoma-following-treatment-with-amputation-and-chemotherapy-with-and-without-metastasectomy
#20
Hailey Turner, Bernard Séguin, Deanna R Worley, Nicole P Ehrhart, Mary H Lafferty, Stephen J Withrow, Laura E Selmic
OBJECTIVE To determine survival times of selected dogs with metastatic (stage III) osteosarcoma, whether disease-free interval (DFI) was associated with survival time after diagnosis of stage III disease (ie, stage III survival time), and whether a survival benefit of metastasectomy existed. DESIGN Retrospective case series with nested cohort study. ANIMALS 194 client-owned dogs treated for histologically confirmed appendicular osteosarcoma from 1997 through 2009. PROCEDURES Dogs were included if they had stage I or II osteosarcoma at the time of initial evaluation, had amputation of the affected appendage and ≥ 1 dose of chemotherapy afterward, and developed metastasis within the follow-up period or prior to death...
December 1, 2017: Journal of the American Veterinary Medical Association
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