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https://www.readbyqxmd.com/read/29166624/impact-of-processing-methods-on-the-dissolution-of-artemether-from-two-non-ordered-mesoporous-silicas
#1
Hira Tahir, Yasser Shahzad, Laura J Waters, Talib Hussain, Abid Mehmood Yousaf, Tariq Mahmood, Rizwan Sheikh
Poor aqueous solubility is often linked with a poor dissolution rate and ultimately, limited bioavailability of pharmaceutical compounds. This study describes the application of mesoporous materials (Syloid 244 and Syloid AL1) in improving the dissolution rate of a drug with poor aqueous solubility, namely artemether, utilising different processing methods including physical mixing, co-grinding and solid dispersions prepared by solvent evaporation and the lyophilisation technique. The prepared formulations were extensively characterised for their solid-state properties and the drug release attributes were studied...
November 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29166563/mechanochemical-synthesis-of-pharmaceutical-cocrystal-suspensions-via-hot-melt-extrusion-enhancing-cocrystal-yield
#2
Shu Li, Tao Yu, Yiwei Tian, Colette Lagan, David S Jones, Gavin P Andrews
Pharmaceutical cocrystals have attracted increasing attention over the past decade as an alternative way to modify the physicochemical properties and hence improve the bioavailability of a drug, without sacrificing thermodynamic stability. Our previous work has demonstrated the viability of in-situ formation of ibuprofen/isonicotinamide cocrystal suspensions within a matrix carrier via a single-step hot-melt extrusion (HME) process. The key aim of the current work is to establish optimised processing conditions to improve cocrystal yield within extruded matrices...
November 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29166319/cardiometabolic-impact-of-changing-sitting-standing-and-stepping-in-the-workplace
#3
Elisabeth Ah Winkler, Sebastien Chastin, Elizabeth G Eakin, Neville Owen, Anthony D LaMontagne, Marj Moodie, Paddy C Dempsey, Bronwyn A Kingwell, David W Dunstan, Genevieve N Healy
BACKGROUND: According to cross-sectional and acute experimental evidence, reducing sitting time should improve cardio-metabolic health risk biomarkers. Furthermore, the improvements obtained may depend on whether sitting is replaced with standing or ambulatory activities. Based on data from the Stand Up Victoria multi-component workplace intervention, we examined this issue using compositional data analysis - a method that can examine and compare all activity changes simultaneously. METHODS: Participants receiving the intervention (n=136 ≥0...
November 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29166189/the-utilization-of-traditional-medicine-to-treat-fever-in-children-in-western-javanese-culture
#4
Tiany Futihat Maulida, Dessie Wanda
Fever regularly affects toddlers and may make their parents uneasy. This study aimed to identify common traditional medicines used by parents to treat their children's fever at home. The study was conducted in Karyasari, Leuwiliang, Bogor District. It was descriptive in design, and the instrument used was a questionnaire developed by the authors. A group of 106 respondents was selected through the cluster sampling method. All respondents were female; the youngest was 20 years old, and the oldest was 53 years old...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166183/the-development-of-an-interactive-health-education-model-based-on-the-djuwita-application-for-adolescent-girls
#5
Sri Djuwitaningsih, Setyowati
Alarming incidents of maternal deaths in Indonesia are due to three major causes: bleeding, sepsis, and hypertension, in addition to other non-obstetric causes and unsafe abortions. Adolescent girls contributed to maternal mortality based on early marriage, unwanted pregnancy, and childbirth. Prevention efforts have been taken through government programs and non-governmental organizations, but in practice those were considered ineffective. Thus, a preventative effort in the form of health education should be made, preferably embedded in a popular mobile application that most teenagers would be apt to use...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166173/cold-plasma-inactivation-of-salmonella-in-prepackaged-mixed-salads-is-influenced-by-cross-contamination-sequence
#6
Sarah M Hertrich, Glenn Boyd, Joseph Sites, Brendan A Niemira
Customer demand for convenient food products has led to an increased production of prepackaged and ready-to-eat food products. Most of these products rely mainly on surface disinfection and other traditional approaches to ensure shelf life and safety. Novel processing techniques, such as cold plasma, are currently being investigated to enhance the safety and shelf life of prepacked foods. The purpose of this study was to determine the effects of cold plasma corona discharge on the inactivation of Salmonella on prepackaged, tomato-and-lettuce mixed salads...
November 22, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29166081/three-sources-of-errors-in-the-ehrenfest-treatment-of-inelastic-scattering-and-possible-ways-of-resolving-them
#7
Alexander Semenov, Dmitri Babikov
In order to identify the origin of possible errors in the mixed quantum/classical approach to inelastic scattering [A. Semenov and D. Babikov, J. Chem. Phys. 140, 044306 (2014) and A. Semenov, M.-L. Dubernet, and D. Babikov, J. Chem. Phys. 141, 114304 (2014)], a simplified model is considered that consists of one intermolecular degree of freedom and two intramolecular states, coupled by a simple potential. For this system, analytic derivations are carried out to determine (i) the exact quantum mechanical solution of the inelastic scattering problem, (ii) a simplified version of it with all oscillatory terms neglected, and (iii) the Ehrenfest solution in which the translational motion is described by the mean-field trajectory while the internal molecular motion is treated by the time-dependent Schrodinger equation...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166064/interaction-component-analysis-of-the-effects-of-urea-and-its-alkylated-derivatives-on-the-structure-of-t4-lysozyme
#8
Yu Yamamori, Nobuyuki Matubayasi
The effects of urea and its alkylated derivatives on the structure of T4-lysozyme were analyzed from the standpoint of energetics. Molecular dynamics simulations were conducted with explicit solvent, and the energy-representation method was employed to compute the free energy of transfer of the protein from pure-water solvent to the mixed solvents of water with urea, methylurea, 1,1-dimethylurea, and isopropylurea. Through the decomposition of the transfer free energy into the cosolvent and water contributions, it was observed that the former is partially cancelled by the latter and governs the total free energy of transfer...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165994/from-graphene-oxide-to-reduced-graphene-oxide-impact-on-physiochemical-and-mechanical-properties-of-graphene%C3%A2-cement-composites
#9
Aliakbar Gholampour, Meisam Valizadeh Kiamahalleh, Diana N H Tran, Togay Ozbakkaloglu, Dusan Losic
Graphene materials have been extensively explored and successfully used to improve performances of cement composites. These formulations were mainly optimized based on different dosages of graphene additives, but with lack of understanding how other parameters such as surface chemistry, size, charge, and defects of graphene structures could impact on physiochemical and mechanical properties of final material. This paper presents the first experimental study to evaluate the influence of oxygen functional groups of graphene and defectiveness of graphene structures on the axial tension and compression properties of graphene-cement mortar composites...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29165920/diabetes-related-complications-which-research-topics-matter-to-diverse-patients-and-caregivers
#10
Maman Joyce Dogba, Mylène Tantchou Dipankui, Selma Chipenda Dansokho, France Légaré, Holly O Witteman
BACKGROUND: Diabetes is a chronic disease with increasing prevalence worldwide. Although research has improved its treatment and management, little is known about which research topics matter to people living with diabetes, particularly among under-represented groups. OBJECTIVES: To explore the importance of research topics among a diverse range of people living with any type of diabetes or caring for someone living with any type of diabetes. METHODS: We used a convergent mixed-method design with quantitative and qualitative aspects...
November 22, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29165779/resilience-to-post-traumatic-stress-among-world-trade-center-survivors-a-mixed-methods-study
#11
Lisa M Gargano, Sindhushree Hosakote, Qi Zhi, Kristine A Qureshi, Robyn R Gershon
The purpose of this study was to identify individual characteristics, behaviors, and psychosocial factors associated with symptoms of post-traumatic stress disorder (PTSD) among World Trade Center (WTC) disaster evacuation survivors. The study utilized a mixed-method design. In-depth interviews were conducted using a prepared script. PTSD was assessed using the PTSD checklist-civilian (PCL-C; a score ≥ 50 indicates probable PTSD). Thematic analysis was conducted to identify factors associated with PTSD. A purposive sample of 29 WTC evacuees was recruited using a multimodal recruitment strategy...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29165479/evaluation-of-the-impact-of-food-matrix-change-on-the-in-vitro-bioaccessibility-of-carotenoids-in-pumpkin-cucurbita-moschata-slices-during-two-drying-processes
#12
Zhongyuan Zhang, Xiaoyan Wang, Yixiang Li, Qiuyu Wei, Chunju Liu, Meimei Nie, Dajing Li, Yadong Xiao, Chunquan Liu, Lang Xu, Min Zhang, Ning Jiang
The food matrix is a limiting factor in determining the bioaccessibility of carotenoids. The impact of food matrix change on the bioaccessibility of carotenoids during drying processes is still unknown. The effect of intermittent microwave vacuum-assisted drying (IMVD) and hot air drying (HAD) on the in vitro liberation and micellization of carotenoids in pumpkin slices was studied. This variable depended on the changes of the matrix driven by the drying process. Different changes in the cell morphology and carotenoid distribution of pumpkin slices during the two processing methods were observed...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29165023/adapting-the-elder-abuse-suspicion-index%C3%A2-for-use-in-long-term-care-a-mixed-methods-approach
#13
Stephanie A Ballard, Mark J Yaffe, Linda August, Deniz Cetin-Sahin, Machelle Wilchesky
Currently available elder abuse screening and identification tools have limitations for use in long-term care (LTC). This mixed-methods study sought to explore the appropriateness of using the Elder Abuse Suspicion Index© (a suspicion tool originally created for use with older adults in the ambulatory setting with Mini-Mental State Examination scores ≥ 24) with similarly cognitively functioning persons residing in LTC. Results were informed by a literature review, Internet-based consultations with elder abuse experts across Canada ( n = 19), and data obtained from two purposively selected focus groups ( n = 7 local elder abuse experts; n = 7 experienced front-line LTC clinicians)...
September 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29165006/effect-of-non-steroidal-anti-inflammatory-drugs-on-postoperative-respiratory-and-heart-rate-in-cats-subjected-to-ovariohysterectomy
#14
Odd V Höglund, Barbara Dyall, Victoria Gräsman, Anna Edner, Ulf Olsson, Katja Höglund
Objectives The use of physiological parameters such as respiratory rate and heart rate to assess pain has long been discussed. The aim of the study was to compare postoperative respiratory rate and heart rate in cats subjected to flank ovariohysterectomy treated with a preoperative non-steroidal anti-inflammatory drug (NSAID) or no NSAID, and determine whether these parameters are suitable for postoperative pain assessment in cats. We hypothesised that cats without an NSAID would experience more postoperative pain, which may increase heart rate and respiratory rate...
November 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29164987/quality-of-life-for-late-life-patients-mixed-methods-evaluation-of-a-whole-person-approach-for-patients-with-chronic-illnesses
#15
Tetyana Shippee, Nathan Shippee, Karl Fernstrom, Patrick Mobley, Monica Frazer, Judy Jou, Heather Britt
Quality of life (QOL) for patients with serious illness in late life is important for patients and policy makers and has implications for improved care delivery. This mixed-methods evaluation examined the effectiveness of a new whole-person approach to late life care-the LifeCourse-which provides patients with ongoing, across-setting assistance from lay health care workers, supported by a clinical team. We investigated whether participation in LifeCourse improves QOL for intervention patients, compared with usual care controls...
October 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164720/mechanistic-insights-into-growth-of-surface-mounted-metal-organic-framework-films-resolved-by-infrared-nano-spectroscopy
#16
Guusje Delen, Zoran Ristanović, Laurens D B Mandemaker, Bert M Weckhuysen
Control over assembly, orientation, and defect-free growth of metal-organic framework (MOF) films is crucial for their future applications. A layer-by-layer approach is considered a suitable method to synthesize highly oriented films of numerous MOF topologies, but the initial stages of the film growth remain poorly understood. Here we use a combination of infrared (IR) reflection absorption spectroscopy and atomic force microscopy (AFM)-IR imaging to investigate the assembly and growth of a surface mounted MOF (SURMOF) film, specifically HKUST-1...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29164637/internal-pilot-design-for-balanced-repeated-measures
#17
Xinrui Zhang, Keith E Muller, Maureen M Goodenow, Yueh-Yun Chi
Repeated measures are common in clinical trials and epidemiological studies. Designing studies with repeated measures requires reasonably accurate specifications of the variances and correlations to select an appropriate sample size. Underspecifying the variances leads to a sample size that is inadequate to detect a meaningful scientific difference, while overspecifying the variances results in an unnecessarily large sample size. Both lead to wasting resources and placing study participants in unwarranted risk...
November 21, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29164224/surface-coatings-of-silver-nanowires-lead-to-effective-high-conductivity-high-strain-ultrathin-sensors
#18
Conor S Boland, Umar Khan, Hanane Benameur, Jonathan N Coleman
Integrated sensors for bodily measurements require a sensing material that is highly conductive, flexible, thin and sensitive. It is important that these materials are non-invasive in application but robust in nature to allow for effective, continuous measurement. Herein, we report a comparative study of two simple, scalable methods to produce silver nanowire (AgNW) polyurethane (PU) composite materials: layer-by-layer (LBL) and mixed filtration. Both types of composites formed were ultrathin (∼50 μm) and highly conductive (10(4) S m(-1)), with the LBL method ultimately found to be superior due to its low percolation threshold...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29164209/tuning-the-cytotoxicity-of-ruthenium-ii-para-cymene-complexes-by-mono-substitution-at-a-triphenylphosphine-phenoxydiphenylphosphine-ligand
#19
Lorenzo Biancalana, Stefano Zacchini, Nicola Ferri, Maria Giovanna Lupo, Guido Pampaloni, Fabio Marchetti
The new complexes [RuCl2(η(6)-p-cymene)(κP-Ph2PR)] [R = 4-C6H4OSiMe2(t)Bu, 1; R = 4-C6H4Br, 2; R = OC([double bond, length as m-dash]O)CHCl2, 3; R = OPh, 4; R = O(2-C6H4SiMe2(t)Bu), 5] and [Ru(C2O4)(η(6)-p-cymene){κP-Ph2PO(2-C6H4(SiMe2(t)Bu))}], 6, were obtained in 83-98% yield from Ru(ii) arene precursors by three different synthetic strategies. The unprecedented phosphine Ph2P(O(2-C6H4SiMe2(t)Bu)) was synthesized in 86% yield from 2-C6H4Br(OSiMe2(t)Bu) and Ph2PCl, via intramolecular oxygen to carbon 1,3 migration of the silyl group (retro-Brook rearrangement)...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29164191/characterising-the-evaporation-kinetics-of-water-and-semi-volatile-organic-compounds-from-viscous-multicomponent-organic-aerosol-particles
#20
Stephen Ingram, Chen Cai, Young-Chul Song, David R Glowacki, David O Topping, Simon O'Meara, Jonathan P Reid
The physicochemical changes experienced by organic aerosol particles undergoing dehydration into the surrounding gas phase can be drastic, forcing rapid vitrification of the particle and suppressing internal diffusion. Until recently, experimental studies have concentrated on quantifying diffusional mixing of either water or non-volatile components, while relatively little attention has been paid to the role of semivolatile organic component (SVOC) diffusion and volatilisation in maintaining the equilibrium between the gas and particle phases...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
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