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https://www.readbyqxmd.com/read/28346363/rapid-and-low-cost-crp-measurement-by-integrating-a-paper-based-microfluidic-immunoassay-with-smartphone-crp-chip
#1
Meili Dong, Jiandong Wu, Zimin Ma, Hagit Peretz-Soroka, Michael Zhang, Paul Komenda, Navdeep Tangri, Yong Liu, Claudio Rigatto, Francis Lin
Traditional diagnostic tests for chronic diseases are expensive and require a specialized laboratory, therefore limiting their use for point-of-care (PoC) testing. To address this gap, we developed a method for rapid and low-cost C-reactive protein (CRP) detection from blood by integrating a paper-based microfluidic immunoassay with a smartphone (CRP-Chip). We chose CRP for this initial development because it is a strong biomarker of prognosis in chronic heart and kidney disease. The microfluidic immunoassay is realized by lateral flow and gold nanoparticle-based colorimetric detection of the target protein...
March 26, 2017: Sensors
https://www.readbyqxmd.com/read/28329105/medical-three-dimensional-printing-opens-up-new-opportunities-in-cardiology-and-cardiac-surgery
#2
Thomas Bartel, Andrew Rivard, Alejandro Jimenez, Carlos A Mestres, Silvana Müller
Advanced percutaneous and surgical procedures in structural and congenital heart disease require precise pre-procedural planning and continuous quality control. Although current imaging modalities and post-processing software assists with peri-procedural guidance, their capabilities for spatial conceptualization remain limited in two- and three-dimensional representations. In contrast, 3D printing offers not only improved visualization for procedural planning, but provides substantial information on the accuracy of surgical reconstruction and device implantations...
February 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28324943/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#3
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28317159/surgical-planning-for-a-complex-double-outlet-right-ventricle-using-3d-printing
#4
Puneet Bhatla, Justin T Tretter, Sathish Chikkabyrappa, Sujata Chakravarti, Ralph S Mosca
Rapid prototyping may be beneficial in properly selected cases of complex congenital heart disease, providing detailed anatomical understanding that helps to guide potential surgical and cardiac catheterization interventions. We present a case of double-outlet right ventricle, where the decision to obtain a three-dimensional printed model helped for better understanding of the anatomy, with the additional advantage of surgical simulation in planning the surgical approach and type of surgical repair.
March 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28302738/impact-of-three-dimensional-printing-on-the-study-and-treatment-of-congenital-heart-disease
#5
Matthew Bramlet, Laura Olivieri, Kanwal Farooqi, Beth Ripley, Meghan Coakley
No abstract text is available yet for this article.
March 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28285203/flexible-heartbeat-sensor-for-wearable-device
#6
Yeon Hwa Kwak, Wonhyo Kim, Kwang Bum Park, Kunnyun Kim, Sungkyu Seo
We demonstrate a flexible strain-gauge sensor and its use in a wearable application for heart rate detection. This polymer-based strain-gauge sensor was fabricated using a double-sided fabrication method with polymer and metal, i.e., polyimide and nickel-chrome. The fabrication process for this strain-gauge sensor is compatible with the conventional flexible printed circuit board (FPCB) processes facilitating its commercialization. The fabricated sensor showed a linear relation for an applied normal force of more than 930 kPa, with a minimum detectable force of 6...
March 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28284205/usage-of-3d-models-of-tetralogy-of-fallot-for-medical-education-impact-on-learning-congenital-heart-disease
#7
RANDOMIZED CONTROLLED TRIAL
Yue-Hin Loke, Ashraf S Harahsheh, Axel Krieger, Laura J Olivieri
BACKGROUND: Congenital heart disease (CHD) is the most common human birth defect, and clinicians need to understand the anatomy to effectively care for patients with CHD. However, standard two-dimensional (2D) display methods do not adequately carry the critical spatial information to reflect CHD anatomy. Three-dimensional (3D) models may be useful in improving the understanding of CHD, without requiring a mastery of cardiac imaging. The study aimed to evaluate the impact of 3D models on how pediatric residents understand and learn about tetralogy of Fallot following a teaching session...
March 11, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28281732/utilisation-of-three-dimensional-printed-heart-models-for-operative-planning-of-complex-congenital-heart-defects
#8
Peter Olejník, Matej Nosal, Tomas Havran, Adriana Furdova, Maros Cizmar, Michal Slabej, Andrej Thurzo, Pavol Vitovic, Martin Klvac, Tibor Acel, Jozef Masura
BACKGROUND: To evaluate the accuracy of the three-dimensional printing of cardiovascular structures.To explore whether utilization of three-dimensional printed heart replicas can improve surgical and catheter interventional planning in patients with complex congenital heart defects. METHODS: Between December 2014 and November 2015, we fabricated n=8 cardiovascular models based on computed tomography data in patients with complex spatial anatomical relationships of cardiovascular structures...
March 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28277924/follow-your-heart-development-of-an-evidence-based-campaign-empowering-older-women-with-hiv-to-participate-in-a-large-scale-cardiovascular-disease-prevention-trial
#9
Markella V Zanni, Kathleen Fitch, Corinne Rivard, Laura Sanchez, Pamela S Douglas, Steven Grinspoon, Laura Smeaton, Judith S Currier, Sara E Looby
BACKGROUND: Women's under-representation in HIV and cardiovascular disease (CVD) research suggests a need for novel strategies to ensure robust representation of women in HIV-associated CVD research. OBJECTIVE: To elicit perspectives on CVD research participation among a community-sample of women with or at risk for HIV, and to apply acquired insights toward the development of an evidence-based campaign empowering older women with HIV to participate in a large-scale CVD prevention trial...
March 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28268011/hands-on-surgical-training-of-congenital-heart-surgery-using-3-dimensional-print-models
#10
Shi-Joon Yoo, Thomas Spray, Erle H Austin, Tae-Jin Yun, Glen S van Arsdell
OBJECTIVE: Patient-based congenital heart surgery (CHS) training is opportunity-based and difficult. Three-dimensional (3D) print models of the heart were used for hands-on surgical training (HOST) at the 2015 AATS and subsequently in 2 local institutions. We aim to introduce the process of 3D printing for surgical simulation and to present the attendee's responses. METHODS: Using CT or MR angiograms, the models of congenital heart disease were created and printed with flexible rubberlike material...
February 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28260327/-research-progress-of-3d-printing-in-the-field-of-valvular-heart-disease
#11
Y Wang, M Y Wang, X S Ren
No abstract text is available yet for this article.
February 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28249831/negotiating-tensions-between-theory-and-design-in-the-development-of-mailings-for-people-recovering-from-acute-coronary-syndrome
#12
Holly O Witteman, Justin Presseau, Emily Nicholas Angl, Iffat Jokhio, J D Schwalm, Jeremy M Grimshaw, Beth Bosiak, Madhu K Natarajan, Noah M Ivers
BACKGROUND: Taking all recommended secondary prevention cardiac medications and fully participating in a formal cardiac rehabilitation program significantly reduces mortality and morbidity in the year following a heart attack. However, many people who have had a heart attack stop taking some or all of their recommended medications prematurely and many do not complete a formal cardiac rehabilitation program. OBJECTIVE: The objective of our study was to develop a user-centered, theory-based, scalable intervention of printed educational materials to encourage and support people who have had a heart attack to use recommended secondary prevention cardiac treatments...
March 1, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28242061/patient-specific-in-vitro-models-for-hemodynamic-analysis-of-congenital-heart-disease-additive-manufacturing-approach
#13
Rafael Medero, Sylvana García-Rodríguez, Christopher J François, Alejandro Roldán-Alzate
Non-invasive hemodynamic assessment of total cavopulmonary connection (TCPC) is challenging due to the complex anatomy. Additive manufacturing (AM) is a suitable alternative for creating patient-specific in vitro models for flow measurements using four-dimensional (4D) Flow MRI. These in vitro systems have the potential to serve as validation for computational fluid dynamics (CFD), simulating different physiological conditions. This study investigated three different AM technologies, stereolithography (SLA), selective laser sintering (SLS) and fused deposition modeling (FDM), to determine differences in hemodynamics when measuring flow using 4D Flow MRI...
February 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28226721/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#14
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Stuart Norris, Brett Cowan, Pau Medrano-Gracia, Kathleen Gilbert, Mark Webster, Alistair Young, Susann Beier, John Cater, John Ormiston
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28214078/the-optimize-heart-failure-care-program-initial-lessons-from-global-implementation
#15
Martin R Cowie, Yuri M Lopatin, Clara Saldarriaga, Cândida Fonseca, David Sim, Jose Antonio Magaña, Denilson Albuquerque, Marcelo Trivi, Gustavo Moncada, Baldomero A González Castillo, Mario Osvaldo Speranza Sánchez, Edward Chung
Hospitalization for heart failure (HF) places a major burden on healthcare services worldwide, and is a strong predictor of increased mortality especially in the first three months after discharge. Though undesirable, hospitalization is an opportunity to optimize HF therapy and advise clinicians and patients about the importance of continued adherence to HF medication and regular monitoring. The Optimize Heart Failure Care Program (www.optimize-hf.com), which has been implemented in 45 countries, is designed to improve outcomes following HF hospitalization through inexpensive initiatives to improve prescription of appropriate drug therapies, patient education and engagement, and post-discharge planning...
February 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28207342/cumulative-lifetime-marijuana-use-and-incident-cardiovascular-disease-in-middle-age-the-coronary-artery-risk-development-in-young-adults-cardia-study
#16
Jared P Reis, Reto Auer, Michael P Bancks, David C Goff, Cora E Lewis, Mark J Pletcher, Jamal S Rana, James M Shikany, Stephen Sidney
OBJECTIVES: To investigate the effects of marijuana in the development of incident cardiovascular and cerebrovascular outcomes. METHODS: Participants were 5113 adults aged 18 to 30 years at baseline (1985-1986) from the Coronary Artery Risk Development in Young Adults study, who were followed for more than 25 years. We estimated cumulative lifetime exposure to marijuana using repeated assessments collected at examinations every 2 to 5 years. The primary outcome was incident cardiovascular disease (CVD) through 2013...
April 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28205200/three-dimensional-printing-technology-supports-surgery-planning-in-patients-with-complex-congenital-heart-defects
#17
Radosław Jaworski, Ireneusz Haponiuk, Maciej Chojnicki, Henryk Olszewski, Paweł Lulewicz
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28183437/cardiac-3d-printing-and-its-future-directions
#18
REVIEW
Marija Vukicevic, Bobak Mosadegh, James K Min, Stephen H Little
Three-dimensional (3D) printing is at the crossroads of printer and materials engineering, noninvasive diagnostic imaging, computer-aided design, and structural heart intervention. Cardiovascular applications of this technology development include the use of patient-specific 3D models for medical teaching, exploration of valve and vessel function, surgical and catheter-based procedural planning, and early work in designing and refining the latest innovations in percutaneous structural devices. In this review, we discuss the methods and materials being used for 3D printing today...
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28162139/clinical-application-of-three-dimensional-printing-to-the-management-of-complex-univentricular-hearts-with-abnormal-systemic-or-pulmonary-venous-drainage
#19
Eimear McGovern, Eoin Kelleher, Aisling Snow, Kevin Walsh, Bassem Gadallah, Shelby Kutty, John M Redmond, Colin J McMahon
In recent years, three-dimensional printing has demonstrated reliable reproducibility of several organs including hearts with complex congenital cardiac anomalies. This represents the next step in advanced image processing and can be used to plan surgical repair. In this study, we describe three children with complex univentricular hearts and abnormal systemic or pulmonary venous drainage, in whom three-dimensional printed models based on CT data assisted with preoperative planning. For two children, after group discussion and examination of the models, a decision was made not to proceed with surgery...
February 6, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28148989/nano-au-cmwcnt-modified-speb-gene-specific-amperometric-sensor-for-rapidly-detecting-streptococcus-pyogenes-causing-rheumatic-heart-disease
#20
Ankur Kaushal, Swati Singh, Ashok Kumar, Dinesh Kumar
A specific 5' NH2 labeled DNA probe of speB gene was immobilized onto the gold nanoparticles/carboxylated multi walled carbon nanotubes (Nano-Au/cMWCNT) screen printed electrode using EDC/NHS cross linking chemistry. This was followed by hybridization with 0.5-50 ng/6 µl of single stranded genomic DNA Streptococcus pyogenes infected patient throat swab samples. Electrochemical amperometric assay was deciphered by using cyclic voltammetry (CV) with methylene blue a redox indicator. The sensor had a sensitivity of 104...
March 2017: Indian Journal of Microbiology
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