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https://www.readbyqxmd.com/read/28817329/assessing-years-of-life-lost-versus-number-of-deaths-in-the-united-states-1995-2015
#1
Glen B Taksler, Michael B Rothberg
OBJECTIVES: To assess years of life lost to each cause of death in the United States between 1995 and 2015, and compare it with the number of deaths. METHODS: We used Vital Statistics mortality data and defined "life-years lost" as remaining life expectancy for each decedent's age, sex, and race. We calculated the share of life-years lost to each cause of death in each year, and examined reasons for changes. RESULTS: In 2015, heart disease caused the most deaths, but cancer caused 23% more life-years lost...
August 17, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28780843/-initial-study-of-transthoracic-echocardiography-guided-three-dimensional-printing-on-the-application-of-assessment-of-structural-heart-disease
#2
Y B Zhu, J S Liu, L Q Wang, X Guan, Y J Luo, J Geng, Q G Geng, Y J Lin, L X Zhang, X X Li, Y P Lu
Objective: To investigate the feasibility and diagnostic value of preoperative transthoracic echocardiography guided three dimensional printing model (TTE Guided 3DPM) on the assessment of structural heart disease (SHD). Methods: From February 2016 to October 2016, 44 patients underwent cardiac surgery in Tianjin Chest Hospital, forty-four patients were assessed preoperatively using TTE Guided 3DPM, including 25 males and 19 females, aged 3-75 years, with an average of (44±22) years. compared to conventional three dimensional transthoracic echocardiography (3D-TTE), and took direct intraoperative findings as "Golden Standard" simultaneously...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28775383/high-resolution-3-dimensional-imaging-of-the-human-cardiac-conduction-system-from-microanatomy-to-mathematical-modeling
#3
Robert S Stephenson, Andrew Atkinson, Petros Kottas, Filip Perde, Fatemeh Jafarzadeh, Mike Bateman, Paul A Iaizzo, Jichao Zhao, Henggui Zhang, Robert H Anderson, Jonathan C Jarvis, Halina Dobrzynski
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system. Here, using contrast enhanced micro-computed tomography, we present, in attitudinally appropriate fashion, the first 3-dimensional representations of the cardiac conduction system within the intact human heart. We show that cardiomyocyte orientation can be extracted from these datasets at spatial resolutions approaching the single cell...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774381/first-in-human-closed-chest-transcatheter-superior-cavopulmonary-anastomosis
#4
Kanishka Ratnayaka, John W Moore, Rodrigo Rios, Robert J Lederman, Sanjeet R Hegde, Howaida G El-Said
BACKGROUND: In the care of patients with congenital heart disease, percutaneous interventional treatments have supplanted many surgical approaches for simple lesions, such as atrial septal defect. By contrast, complex congenital heart defects continue to require open-heart surgery. In single-ventricle patients, a staged approach is employed, which requires multiple open-heart surgeries and significant attendant morbidity and mortality. A nonsurgical transcatheter alternative would be attractive...
August 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28772053/heart-failure-awareness-survey-in-germany-general-knowledge-on-heart-failure-remains-poor
#5
Christine Zelenak, Sara Radenovic, Lindy Musial-Bright, Elvis Tahirovic, Mesud Sacirovic, Chong-Bin Lee, Diana Jahandar-Lashki, Simone Inkrot, Tobias Daniel Trippel, Andreas Busjahn, Djawid Hashemi, Rolf Wachter, Sabine Pankuweit, Stefan Störk, Burkert Pieske, Frank Edelmann, Hans-Dirk Düngen
AIMS: Previous studies demonstrated poor public awareness of heart failure (HF) compared with myocardial infarction and stroke. With respect to several activities to improve HF awareness in recent years, we present data on the development of HF awareness and information sources in Germany over 8 years. METHODS AND RESULTS: In 2007, 2012, and 2015, respectively, 2531, 359, and 171 respondents answered questions about causes, presentation, prognosis, and treatment of HF from a survey developed by the German Competence Network HF...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28736923/applications-of-additive-manufacturing-in-dentistry-a-review
#6
REVIEW
Aishwarya Bhargav, Vijayavenkatraman Sanjairaj, Vinicius Rosa, Lu Wen Feng, Jerry Fuh Yh
Additive manufacturing (AM) or 3D printing has been hailed as the third industrial revolution as it has caused a paradigm shift in the way objects have been manufactured. Conventionally, converting a raw material to a fully finished and assembled, usable product comprises several steps which can be eliminated by using this process as functional products can be created directly from the raw material at a fraction of the time originally consumed. Thus, AM has found applications in several sectors including automotive, aerospace, printed electronics, and healthcare...
July 24, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28726575/bioprinting-pattern-dependent-electrical-mechanical-behavior-of-cardiac-alginate-implants-characterization-and-ex-vivo-phase-contrast-microtomography-assessment
#7
Mohammad Izadifar, Paul Babyn, Michael E Kelly, Dean Chapman, Xiongbiao Chen
Three-dimensional (3D)-bioprinting techniques may be used to modulate electrical/mechanical properties and porosity of hydrogel constructs for fabrication of suitable cardiac implants. Notably, characterization of these properties after implantation remains a challenge, raising the need for the development of novel quantitative imaging techniques for monitoring hydrogel implant behavior in-situ. This study aims to (i) assess the influence of hydrogel bioprinting patterns on electrical/mechanical behavior of cardiac implants based on a 3D-printing technique and (ii) investigate the potential of synchrotron X-ray phase contrast computed tomography (PCI-CT) for estimating elastic modulus/impedance/porosity and microstructural features of 3D-printed cardiac implants in-situ via an ex-vivo study...
July 20, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28721726/3d-printed-earable-smart-devices-for-real-time-detection-of-core-body-temperature
#8
Hiroki Ota, Minghan Chao, Yuji Gao, Eric Wu, Li-Chia Tai, Kevin Chen, Yasutomo Matsuoka, Kosuke Iwai, Hossain M Fahad, Wei Gao, Hnin Yin Yin Nyein, Liwei Lin, Ali Javey
Real-time detection of basic physiological parameters such as blood pressure and heart rate is an important target in wearable smart devices for healthcare. Among these, the core body temperature is one of the most important basic medical indicators of fever, insomnia, fatigue, metabolic functionality, and depression. However, traditional wearable temperature sensors are based upon the measurement of skin temperature, which can vary dramatically from the true core body temperature. Here, we demonstrate a three-dimensional (3D) printed wearable "earable" smart device that is designed to be worn on the ear to track core body temperature from the tympanic membrane (i...
July 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721493/modelling-of-lesions-associated-with-functional-mitral-regurgitation-in-an-ex-vivo-platform
#9
Michal Jaworek, Federico Lucherini, Claudia Romagnoni, Guido Gelpi, Monica Contino, Paolo Romitelli, Carlo Antona, Gianfranco B Fiore, Riccardo Vismara
Functional mitral regurgitation (FMR) is a complex pathology involving valvular and subvalvular structures reconfiguration, and its treatment is considered challenging. There is a lack of experimental models allowing for reliable preclinical FMR treatments' evaluation in a realistic setting. A novel approach to simulate FMR was developed and incorporated into an ex vivo passive beating heart platform. FMR was obtained by dilating the mitral annulus (MA) mainly in the antero-posterior direction and displacing the papillary muscles (PMs) apically and laterally by ad hoc designed and 3D printed dilation and displacing devices...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28717801/mimicking-arterial-thrombosis-in-a-3d-printed-microfluidic-in-vitro-vascular-model-based-on-computed-tomography-angiography-data
#10
Pedro F Costa, Hugo J Albers, John E A Linssen, Heleen H T Middelkamp, Linda van der Hout, Robert Passier, Albert van den Berg, Jos Malda, Andries D van der Meer
Arterial thrombosis is the main instigating factor of heart attacks and strokes, which result in over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors from the blood and the vessel wall, and it also relies strongly on 3D vessel geometry and local blood flow patterns. Microfluidic chip-based vascular models allow controlled in vitro studies of the interaction between vessel wall and blood in thrombosis, but until now, they could not fully recapitulate the 3D geometry and blood flow patterns of real-life healthy or diseased arteries...
August 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28715970/scaffold-in-scaffold-potential-to-induce-growth-and-differentiation-of-cardiac-progenitor-cells
#11
Matteo Ciocci, Federico Mochi, Felicia Carotenuto, Emilia Di Giovanni, Paolo Prosposito, Roberto Francini, Fabio De Matteis, Igor Reshetov, Mauro Casalboni, Sonia Melino, Paolo Di Nardo
The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical signals concurring to modulate cell function to ultimately drive cell fate. In the present study, a combination of optimal mechanical and biochemical properties has been considered to design a one-component 3D multitextured hydrogel scaffold in order to favor cell-scaffold interactions...
July 17, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28691283/a-soft-total-artificial-heart-first-concept-evaluation-on-a-hybrid-mock-circulation
#12
Nicholas H Cohrs, Anastasios Petrou, Michael Loepfe, Maria Yliruka, Christoph M Schumacher, A Xavier Kohll, Christoph T Starck, Marianne Schmid Daners, Mirko Meboldt, Volkmar Falk, Wendelin J Stark
The technology of 3D-printing has allowed the production of entirely soft pumps with complex chamber geometries. We used this technique to develop a completely soft pneumatically driven total artificial heart from silicone elastomers and evaluated its performance on a hybrid mock circulation. The goal of this study is to present an innovative concept of a soft total artificial heart (sTAH). Using the form of a human heart, we designed a sTAH, which consists of only two ventricles and produced it using a 3D-printing, lost-wax casting technique...
July 10, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28677508/multimodality-imaging-for-interventional-cardiology
#13
Simona Celi, Nicola Martini, Luigi Emilio Pastormerlo, Vincenzo Positano, Sergio Berti
BACKGROUND: In the last decades, interventional cardiology has received fast and wide implementation as an effective alternative treatment to surgery for several congenital and acquired diseases. In this scenario, imaging provides solutions for most clinical needs, from diagnosis to prognosis and risk stratification, as well as anatomical and functional assessment. METHODS: In this review article, we present recent innovations in medical imaging for structural heart disease and coronary artery disease, emphasizing the progress achieved in the field of multimodality imaging and the solutions proposed to some as-yet unresolved technical problems for safe and effective procedural performance...
July 4, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28664892/potential-of-propagation-based-synchrotron-x-ray-phase-contrast-computed-tomography-for-cardiac-tissue-engineering
#14
Mohammad Izadifar, Paul Babyn, Dean Chapman, Michael E Kelly, Xiongbiao Chen
Hydrogel-based cardiac tissue engineering offers great promise for myocardial infarction repair. The ability to visualize engineered systems in vivo in animal models is desired to monitor the performance of cardiac constructs. However, due to the low density and weak X-ray attenuation of hydrogels, conventional radiography and micro-computed tomography are unable to visualize the hydrogel cardiac constructs upon their implantation, thus limiting their use in animal systems. This paper presents a study on the optimization of synchrotron X-ray propagation-based phase-contrast imaging computed tomography (PCI-CT) for three-dimensional (3D) visualization and assessment of the hydrogel cardiac patches...
July 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28634957/bioprinting-of-3d-tissue-models-using-decellularized-extracellular-matrix-bioink
#15
Falguni Pati, Dong-Woo Cho
Bioprinting provides an exciting opportunity to print and pattern all the components that make up a tissue-cells and extracellular matrix (ECM) material-in three dimensions (3D) to generate tissue analogues. A large number of materials have been used for making bioinks; however, majority of them cannot represent the complexity of natural ECM and thus are unable to reconstitute the intrinsic cellular morphologies and functions. We present here a method for making of bioink from decellularized extracellular matrices (dECMs) and a protocol for bioprinting of cell-laden constructs with this novel bioink...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28624249/the-role-of-3-d-heart-models-in-planning-and-executing-interventional-procedures
#16
REVIEW
Elena K Grant, Laura J Olivieri
Percutaneous interventions aimed at addressing congenital and structural heart disease are simultaneously becoming more common and more complex as time progresses. An increasing number of heart defects that had previously required open heart surgery can now be successfully addressed in the cardiac catheterization laboratory. Adequate preprocedural preparation for these novel, complex procedures is critical to ensure their success. Diagnostic data can be collected before the intervention and displayed in multiple formats during the procedure...
February 24, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28612929/flexible-organic-inorganic-hybrid-near-infrared-photoplethysmogram-sensor-for-cardiovascular-monitoring
#17
Huihua Xu, Jing Liu, Jie Zhang, Guodong Zhou, Ningqi Luo, Ni Zhao
Wearable photoplethysmogram (PPG) sensors offer convenient and informative measurements for evaluating daily physiological states of individuals. In this work, epidermal and flexible near-infrared (NIR) PPG sensors integrating a low-power, high-sensitivity organic phototransistor (OPT) with a high-efficiency inorganic light-emitting diode are developed. By exploiting an organic bulk heterojunction active layer and a bilayer gate dielectric design, a low voltage (<3 V) operated OPT with NIR responsivity as high as 3...
June 14, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28574314/a-microcontroller-based-simulation-of-dural-venous-sinus-injury-for-neurosurgical-training
#18
Daniel R Cleary, Dominic A Siler, Nathaniel Whitney, Nathan R Selden
OBJECTIVE Surgical simulation has the potential to supplement and enhance traditional resident training. However, the high cost of equipment and limited number of available scenarios have inhibited wider integration of simulation in neurosurgical education. In this study the authors provide initial validation of a novel, low-cost simulation platform that recreates the stress of surgery using a combination of hands-on, model-based, and computer elements. Trainee skill was quantified using multiple time and performance measures...
June 2, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28566818/three-dimensional-printed-cardiac-prototypes-aid-surgical-decision-making-and-preoperative-planning-in-selected-cases-of-complex-congenital-heart-diseases-early-experience-and-proof-of-concept-in-a-resource-limited-environment
#19
Mahesh Kappanayil, Nageshwara Rao Koneti, Rajesh R Kannan, Brijesh P Kottayil, Krishna Kumar
INTRODUCTION: Three-dimensional. (3D) printing is an innovative manufacturing process that allows computer-assisted conversion of 3D imaging data into physical "printouts" Healthcare applications are currently in evolution. OBJECTIVE: The objective of this study was to explore the feasibility and impact of using patient-specific 3D-printed cardiac prototypes derived from high-resolution medical imaging data (cardiac magnetic resonance imaging/computed tomography [MRI/CT]) on surgical decision-making and preoperative planning in selected cases of complex congenital heart diseases (CHDs)...
May 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28545122/spot-a-novel-and-streamlined-microarray-platform-for-observing-cellular-trna-levels
#20
Simon Grelet, Ariel McShane, Eveline Hok, Jensen Tomberlin, Philip H Howe, Renaud Geslain
Recent studies have placed transfer RNA (tRNA), a housekeeping molecule, in the heart of fundamental cellular processes such as embryonic development and tumor progression. Such discoveries were contingent on the concomitant development of methods able to deliver high-quality tRNA profiles. The present study describes the proof of concept obtained in Escherichia coli (E. coli) for an original tRNA analysis platform named SPOt (Streamlined Platform for Observing tRNA). This approach comprises three steps. First, E...
2017: PloS One
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