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https://www.readbyqxmd.com/read/28063755/-congenital-heart-disease-recent-technical-advances-in-three-dimensional-echocardiography
#1
Clement Karsenty, Khaled Hadeed, Philippe Acar
The recent technical advances allow the use in practice of three-dimensional echocardiography in children especially through the new high frequency matrix probe. It is difficult or even impossible to hold breathing during children' acquisition so to avoid motion full volume artifact, one beat and live 3D modes are suitable. 3D echocardiography is more accurate than 2D to assess the size, location, and relationship with surrounding structures of atrial and ventricular septal defects and thus helps in the therapeutic decision...
January 4, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28047923/tu-h-brc-08-use-and-validation-of-flexible-3d-printed-tissue-compensators-for-post-mastectomy-radiation-therapy
#2
D Craft, W Woodward, J Kanke, S Kry, M Salehpour, R Howell
PURPOSE: Patient-specific tissue equivalent compensators can be used for post-mastectomy radiation therapy (PMRT) to achieve homogenous dose distributions with single-field treatments. However, current fabrication methods are time consuming and expensive. 3D-printing technology could overcome these limitations. The purposes of this study were to [1] evaluate materials for 3D-printed compensators [2] design and print a compensator to achieve a uniform thickness to a clinical target volume (CTV), and [3] demonstrate that a single-field electron compensator plan is a clinically feasible treatment option for PMRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038838/-interventional-cardiac-catheterization-in-congenital-heart-disease
#3
François Godart, Ali Houeijeh
Interventional cardiac catheterization has a major place in the management of congenital heart disease. Since the Rashkind atrioseptostomy in mid-1960s, many techniques have been developed. For some, it is necessary to close a cardiac or extracardiac shunt using occluder (double disc system, plug, coil…): closure of atrial septal defect, ventricular septal defect or patent arterial duct. For others, it is necessary to treat a valvular or vascular stenosis using a balloon catheter: dilatation of the pulmonary or the aortic valve, dilatation of aortic coarctation...
December 27, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27990542/3d-templated-fully-automated-microfluidic-input-output-multiplexer-for-endocrine-tissue-culture-and-secretion-sampling
#4
Xiangpeng Li, Jessica C Brooks, Juan Hu, Katarena I Ford, Christopher J Easley
A fully automated, 16-channel microfluidic input/output multiplexer (μMUX) has been developed for interfacing to primary cells and to improve understanding of the dynamics of endocrine tissue function. The device utilizes pressure driven push-up valves for precise manipulation of nutrient input and hormone output dynamics, allowing time resolved interrogation of the cells. The ability to alternate any of the 16 channels from input to output, and vice versa, provides for high experimental flexibility without the need to alter microchannel designs...
December 19, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27972294/preliminary-cost-effectiveness-assessment-of-3d-printed-anatomic-models-for-congenital-heart-diseases
#5
P Tack, L Annemans
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27938900/preclinical-study-of-patient-specific-cell-free-nanofiber-tissue-engineered-vascular-grafts-using-3-dimensional-printing-in-a-sheep-model
#6
Takuma Fukunishi, Cameron A Best, Tadahisa Sugiura, Justin Opfermann, Chin Siang Ong, Toshiharu Shinoka, Christopher K Breuer, Axel Krieger, Jed Johnson, Narutoshi Hibino
BACKGROUND: Tissue-engineered vascular grafts (TEVGs) offer potential to overcome limitations of current approaches for reconstruction in congenital heart disease by providing biodegradable scaffolds on which autologous cells proliferate and provide physiologic functionality. However, current TEVGs do not address the diverse anatomic requirements of individual patients. This study explores the feasibility of creating patient-specific TEVGs by combining 3-dimensional (3D) printing and electrospinning technology...
November 14, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27881911/systematic-review-and-meta-analysis-of-randomized-controlled-trials-on-wenxin-keli
#7
REVIEW
Xiaoyi Wang, Ying Wang, Xiaoyuan Feng, Ying Lu, Yu Zhang, Wenwen Wang, Wentao Zhu
OBJECTIVE: The aim of the study was to evaluate the effectiveness, safety, and cost associated with Wenxin keli in the treatment of cardiovascular diseases based on meta-analysis. METHODS: The terms "Wenxin keli" and "Wenxin" were used as the search terms in the PubMed, ProQuest, Springer, the Cochrane Library, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), and Wan fang electronic databases (from January 2000 to October 2015)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27875647/what-pacemakers-can-teach-us-about-the-ethics-of-maintaining-artificial-organs
#8
Katrina Hutchison, Robert Sparrow
One day soon it may be possible to replace a failing heart, liver, or kidney with a long-lasting mechanical replacement or perhaps even with a 3-D printed version based on the patient's own tissue. Such artificial organs could make transplant waiting lists and immunosuppression a thing of the past. Supposing that this happens, what will the ongoing care of people with these implants involve? In particular, how will the need to maintain the functioning of artificial organs over an extended period affect patients and their doctors and the responsibilities of those who manufacture such devices? Drawing on lessons from the history of the cardiac pacemaker, this article offers an initial survey of the ethical issues posed by the need to maintain and service artificial organs...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27865959/ultrasensitive-cardiac-troponin-i-antibody-based-nanohybrid-sensor-for-rapid-detection-of-human-heart-attack
#9
Deepika Bhatnagar, Inderpreet Kaur, Ashok Kumar
An ultrasensitive cardiac troponin I antibody conjugated with graphene quantum dots (GQD) and polyamidoamine (PAMAM) nanohybrid modified gold electrode based sensor was developed for the rapid detection of heart attack (myocardial infarction) in human. Screen printed gold (Au) electrode was decorated with 4-aminothiophenol for amine functionalization of the Au surface. These amino groups were further coupled with carboxyl functionalities of GQD with EDC-NHS reaction. In order to enhance the sensitivity of the sensor, PAMAM dendrimer was successively embedded on GQD through carbodiimide coupling to provide ultra-high surface area for antibody immobilization...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27851785/implementation-of-patient-centered-education-for-chronic-disease-management-in-uganda-an-effectiveness-study
#10
Trishul Siddharthan, Tracy Rabin, Maureen E Canavan, Faith Nassali, Phillip Kirchhoff, Robert Kalyesubula, Steven Coca, Asghar Rastegar, Felix Knauf
BACKGROUND: The majority of non-communicable disease related deaths occur in low- and middle-income countries. Patient-centered care is an essential component of chronic disease management in high income settings. OBJECTIVE: To examine feasibility of implementation of a validated patient-centered education tool among patients with heart failure in Uganda. DESIGN: Mixed-methods, prospective cohort. SETTINGS: A private and public cardiology clinic in Mulago National Referral and Teaching Hospital, Kampala, Uganda...
2016: PloS One
https://www.readbyqxmd.com/read/27833903/virtual-3d-modeling-of-airways-in-congenital-heart-defects
#11
Simone Speggiorin, Saravanan Durairaj, Branko Mimic, Antonio F Corno
The involvement of the airway is not uncommon in the presence of complex cardiovascular malformations. In these cases, a careful inspection of the relationship between the airway and the vasculature is paramount to plan the surgical procedure. Three-dimensional printing enhanced the visualization of the cardiovascular structure. Unfortunately, IT does not allow to remove selected anatomy to improve the visualization of the surrounding ones. Computerized modeling has the potential to fill this gap by allowing a dynamic handling of different anatomies, increasing the exposure of vessels or bronchi to show their relationship...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27818043/ultrasensitive-nanostructure-sensor-arrays-on-flexible-substrates-for-multiplexed-and-simultaneous-electrochemical-detection-of-a-panel-of-cardiac-biomarkers
#12
Nandhinee Radha Shanmugam, Sriram Muthukumar, Shajee Chaudhry, Jonathan Anguiano, Shalini Prasad
Multiplexed detection of protein biomarkers offers new opportunities for early diagnosis and efficient treatment of complex diseases. Cardiovascular diseases (CVDs) has the highest mortality risk in USA and Europe with 15-20 million cases being reported annually. Cardiac Troponins (T and I) are well established protein biomarkers associated with heart muscle damage and point-of-care monitoring of both these two biomarkers has significant benefits on patient care. A flexible disposable electrochemical biosensor device comprising of vertically oriented zinc oxide (ZnO) nanostructures was developed for rapid and simultaneous screening of cardiac Troponin-I (cTnI) and cardiac-Troponin-T (cTnT) in a point-of-care sensor format...
March 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27786234/applications-of-3d-printing-in-cardiovascular-diseases
#13
REVIEW
Andreas A Giannopoulos, Dimitris Mitsouras, Shi-Joon Yoo, Peter P Liu, Yiannis S Chatzizisis, Frank J Rybicki
3D-printed models fabricated from CT, MRI, or echocardiography data provide the advantage of haptic feedback, direct manipulation, and enhanced understanding of cardiovascular anatomy and underlying pathologies. Reported applications of cardiovascular 3D printing span from diagnostic assistance and optimization of management algorithms in complex cardiovascular diseases, to planning and simulating surgical and interventional procedures. The technology has been used in practically the entire range of structural, valvular, and congenital heart diseases, and the added-value of 3D printing is established...
December 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27784001/clinical-application-of-3d-printed-step-bolus-in-post-total-mastectomy-electron-conformal-therapy
#14
Kwangwoo Park, Sungjin Park, Mi-Jin Jeon, Jinhyun Choi, Jun Won Kim, Yoon Jin Cho, Won-Seok Jang, Yo Sup Keum, Ik Jae Lee
The 3D-printed boluses were used during the radiation therapy of the chest wall in six patients with breast cancer after modified radical mastectomy (MRM). We measured the in-vivo skin doses while both conventional and 3D-printed boluses were placed on the chest wall and compared the mean doses delivered to the ipsilateral lung and the heart. The homogeneity and conformity of the dose distribution in the chest wall for both types of boluses were also evaluated. The uniformity index on the chest skin was improved when the 3D-printed boluses were used, with the overall average skin dose being closer to the prescribed one in the former case (-0...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27778297/intrinsic-cell-stress-is-independent-of-organization-in-engineered-cell-sheets
#15
Inge A E W van Loosdregt, Sylvia Dekker, Patrick W Alford, Cees W J Oomens, Sandra Loerakker, Carlijn V C Bouten
Understanding cell contractility is of fundamental importance for cardiovascular tissue engineering, due to its major impact on the tissue's mechanical properties as well as the development of permanent dimensional changes, e.g., by contraction or dilatation of the tissue. Previous attempts to quantify contractile cellular stresses mostly used strongly aligned monolayers of cells, which might not represent the actual organization in engineered cardiovascular tissues such as heart valves. In the present study, therefore, we investigated whether differences in organization affect the magnitude of intrinsic stress generated by individual myofibroblasts, a frequently used cell source for in vitro engineered heart valves...
October 24, 2016: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/27774881/introductory-considerations-athanasios-koukopoulos-the-man-the-psychiatrist-the-original-thinker
#16
Hagop S Akiskal
What I uttered in Athens moved with apparent emotion [that seem to have not escaped Jules Angst's concern] was spontaneous, except for what is printed in the program book, which has somehow vanished from my office, unlike him with his larger than life figure whose memory will live for as long as he lives in the minds and hearts of all those who were privileged to be his family, colleagues, patients, friends, and… countless others, plus those whose email addresses I cannot locate right now sitting in the sunshine of La Jolla-far away from my loved ones-and wondering what ethnic, genetic and environmental factors-perhaps even several Greek gods combined-to produce the original mind and heart of our Athenian friend who, nonetheless, lived in Rome-and now resting not in the 'atheist' cemetery [it took me 5 minutes to spell this word]-but in our hearts for as long as they will beat-perhaps eventually in another realm, 'from whose bourn'-according to Hamlet-no one has ever returned-that's the promise of the Eternal City-where Athanasios is lying...
October 21, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27770630/3d-printed-complex-tissue-construct-using-stem-cell-laden-decellularized-extracellular-matrix-bioinks-for-cardiac-repair
#17
Jinah Jang, Hun-Jun Park, Seok-Won Kim, Heejin Kim, Ju Young Park, Soo Jin Na, Hyeon Ji Kim, Moon Nyeo Park, Seung Hyun Choi, Sun Hwa Park, Sung Won Kim, Sang-Mo Kwon, Pum-Joon Kim, Dong-Woo Cho
Stem cell therapy is a promising therapeutic method for the treatment of ischemic heart diseases; however, some challenges prohibit the efficacy after cell delivery due to hostile microenvironment of the injured myocardium. 3D printed pre-vascularized stem cell patch can enhance the therapeutic efficacy for cardiac repair through promotion of rapid vascularization after patch transplantation. In this study, stem cell-laden decellularized extracellular matrix bioinks are used in 3D printing of pre-vascularized and functional multi-material structures...
October 14, 2016: Biomaterials
https://www.readbyqxmd.com/read/27736207/neighborhood-disadvantage-poor-social-conditions-and-cardiovascular-disease-incidence-among-african-american-adults-in-the-jackson-heart-study
#18
Sharrelle Barber, DeMarc A Hickson, Xu Wang, Mario Sims, Cheryl Nelson, Ana V Diez-Roux
OBJECTIVES: To examine the impact of neighborhood conditions resulting from racial residential segregation on cardiovascular disease (CVD) risk in a socioeconomically diverse African American sample. METHODS: The study included 4096 African American women (n = 2652) and men (n = 1444) aged 21 to 93 years from the Jackson Heart Study (Jackson, Mississippi; 2000-2011). We assessed neighborhood disadvantage with a composite measure of 8 indicators from the 2000 US Census...
December 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27677879/preoperative-planning-with-three-dimensional-reconstruction-of-patient-s-anatomy-rapid-prototyping-and-simulation-for-endoscopic-mitral-valve-repair
#19
Peyman Sardari Nia, Samuel Heuts, Jean Daemen, Peter Luyten, Jindrich Vainer, Jan Hoorntje, Emile Cheriex, Jos Maessen
OBJECTIVES: Mitral valve repair performed by an experienced surgeon is superior to mitral valve replacement for degenerative mitral valve disease; however, many surgeons are still deterred from adapting this procedure because of a steep learning curve. Simulation-based training and planning could improve the surgical performance and reduce the learning curve. The aim of this study was to develop a patient-specific simulation for mitral valve repair and provide a proof of concept of personalized medicine in a patient prospectively planned for mitral valve surgery...
September 27, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27677762/three-dimensional-printed-models-in-congenital-heart-disease
#20
Massimiliano Cantinotti, Israel Valverde, Shelby Kutty
The purpose of this article is to discuss technical considerations and current applications of three-dimensional (3D) printing in congenital heart disease (CHD). CHD represent an attractive field for the application of 3D printed models, with consistent progress made in the past decade. Current 3D models are able to reproduce complex cardiac and extra-cardiac anatomy including small details with very limited range of errors (<1 mm), so this tool could be of value in the planning of surgical or percutaneous treatments for selected cases of CHD...
September 27, 2016: International Journal of Cardiovascular Imaging
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