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https://www.readbyqxmd.com/read/29470257/dynamic-patient-specific-three-dimensional-simulation-of-mitral-repair-can-we-practice-mitral-repair-preoperatively
#1
Olivia K Ginty, John M Moore, Yuanwei Xu, Wenyao Xia, Satoru Fujii, Daniel Bainbridge, Terry M Peters, Bob B Kiaii, Michael W A Chu
OBJECTIVE: Planned mitral repair strategies are generally established from preoperative echocardiography; however, specific details of the repair are often determined intraoperatively. We propose that three-dimensional printed, patient-specific, dynamic mitral valve models may help surgeons plan and trial all the details of a specific patient's mitral repair preoperatively. METHODS: Using preoperative echocardiography, segmentation, modeling software, and three-dimensional printing, we created dynamic, high-fidelity, patient-specific mitral valve models including the subvalvular apparatus...
February 22, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29453808/three-dimensional-printing-in-congenital-heart-disease-a-systematic-review
#2
REVIEW
Ivan Lau, Zhonghua Sun
Three-dimensional (3D) printing has shown great promise in medicine with increasing reports in congenital heart disease (CHD). This systematic review aims to analyse the main clinical applications and accuracy of 3D printing in CHD, as well as to provide an overview of the software tools, time and costs associated with the generation of 3D printed heart models. A search of different databases was conducted to identify studies investigating the application of 3D printing in CHD. Studies based on patient's medical imaging datasets were included for analysis, while reports on in vitro phantom or review articles were excluded from the analysis...
February 17, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#3
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29440763/rhythm-an-open-source-imaging-toolkit-for-cardiac-panoramic-optical-mapping
#4
Christopher Gloschat, Kedar Aras, Shubham Gupta, N Rokhaya Faye, Hanyu Zhang, Roman A Syunyaev, Roman A Pryamonosov, Jack Rogers, Matthew W Kay, Igor R Efimov
Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29422747/yoga-in-print-media-missing-the-heart-of-the-practice
#5
Heather Freeman, Nadezhda Vladagina, Elika Razmjou, Christiane Brems
Background: Popular media typically portray yoga as an exercise or posture practice despite the reality that yoga comprised eight practices (called limbs) including ethical behavior, conscious lifestyle choices, postures, breathing, introspection, concentration, meditation, and wholeness. Aim: This study assessed the comprehensiveness of yoga practice as represented in articles in the popular yoga magazine, Yoga Journal. It explored the degree to which articles referenced each of the eight limbs of yoga and other contents (e...
September 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/29412085/compliant-buckled-foam-actuators-and-application-in-patient-specific-direct-cardiac-compression
#6
Benjamin C Mac Murray, Chaim C Futran, Jeanne Lee, Kevin W O'Brien, Amir A Amiri Moghadam, Bobak Mosadegh, Meredith N Silberstein, James K Min, Robert F Shepherd
We introduce the use of buckled foam for soft pneumatic actuators. A moderate amount of residual compressive strain within elastomer foam increases the applied force ∼1.4 × or stroke ∼2 × compared with actuators without residual strain. The origin of these improved characteristics is explained analytically. These actuators are applied in a direct cardiac compression (DCC) device design, a type of implanted mechanical circulatory support that avoids direct blood contact, mitigating risks of clot formation and stroke...
February 2018: Soft Robotics
https://www.readbyqxmd.com/read/29409167/three-dimensional-printing-enhances-preparation-for-repair-of-double-outlet-right-ventricular-surgery
#7
Liyun Zhao, Sijie Zhou, Taibing Fan, Bin Li, Weijie Liang, Haoju Dong
OBJECTIVE: To assess the clinical value of three-dimensional (3D) printing technology for treatment strategies for complex double outlet right ventricle (DORV). METHODS: Twenty-five patients with complex double outlet right ventricle were enrolled in this study. The patients were divided into two groups: 3D printing group (eight patients) and a non-3-D printing control group (17 patients). The cardiac images of patients in the 3D printing group were transformed to Digital Imaging and Communications and were segmented and reconstructed to create a heart model...
January 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29399969/role-of-virtual-reality-in-congenital-heart-disease
#8
Chin Siang Ong, Aravind Krishnan, Chen Yu Huang, Philip Spevak, Luca Vricella, Narutoshi Hibino, Juan R Garcia, Lasya Gaur
OBJECTIVE: New platforms for patient imaging present opportunities for improved surgical planning in complex congenital heart disease (CHD). Virtual reality (VR) allows for interactive manipulation of high-resolution representations of patient-specific imaging data, as a supplement to traditional 2D visualizations and 3D printed heart models. DESIGN: We present the novel use of VR for the presurgical planning of cardiac surgery in two infants with complex CHD to demonstrate interactive real-time views of complex intra and extracardiac anatomy...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29376102/quantification-of-uncertainty-in-the-assessment-of-coronary-plaque-in-ccta-through-a-dynamic-cardiac-phantom-and-3d-printed-plaque-model
#9
Taylor Richards, Gregory M Sturgeon, Juan Carlos Ramirez-Giraldo, Geoffrey D Rubin, Lynne Hurwitz Koweek, William Paul Segars, Ehsan Samei
The purpose of this study was to develop a dynamic physical cardiac phantom with a realistic coronary plaque to investigate stenosis measurement accuracy under clinically relevant heart-rates. The coronary plaque model (5 mm diameter, 50% stenosis, and 32 mm long) was designed and 3D-printed with tissue equivalent materials (calcified plaque with iodine-enhanced lumen). Realistic cardiac motion was modeled by converting computational cardiac motion vectors into compression and rotation profiles executed by a commercial base cardiac phantom...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29368113/3d-printed-starmix-drug-loaded-dosage-forms-for-paediatric-applications
#10
Nicolaos Scoutaris, Steven A Ross, Dennis Douroumis
PURPOSE: Three- dimensional (3D) printing has received significant attention as a manufacturing process for pharmaceutical dosage forms. In this study, we used Fusion Deposition Modelling (FDM) in order to print "candy - like" formulations by imitating Starmix® sweets to prepare paediatric medicines with enhanced palatability. METHODS: Hot melt extrusion processing (HME) was coupled with FDM to prepare extruded filaments of indomethacin (IND), hypromellose acetate succinate (HPMCAS) and polyethylene glycol (PEG) formulations and subsequently feed them in the 3D printer...
January 16, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29339932/computerized-versus-hand-scored-health-literacy-tools-a-comparison-of-simple-measure-of-gobbledygook-smog-and-flesch-kincaid-in-printed-patient-education-materials
#11
Kelsey Leonard Grabeel, Jennifer Russomanno, Sandy Oelschlegel, Emily Tester, Robert Eric Heidel
Objective: The research compared and contrasted hand-scoring and computerized methods of evaluating the grade level of patient education materials that are distributed at an academic medical center in east Tennessee and sought to determine if these materials adhered to the American Medical Association's (AMA's) recommended reading level of sixth grade. Methods: Librarians at an academic medical center located in the heart of Appalachian Tennessee initiated the assessment of 150 of the most used printed patient education materials...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29337695/automated-fabrication-of-photopatterned-gelatin-hydrogels-for-organ-on-chips-applications
#12
Janna C Nawroth, Lisa L Scudder, Ryan T Halvorson, Jason Tresback, John P Ferrier, Sean P Sheehy, Alex Cho, Suraj Kannan, Ilona Sunyovszki, Josue A Goss, Patrick H Campbell, Kevin Kit Parker
Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micropatterned substrates, which limits turnover and flexibility of prototyping. We present a rapid and automated method for large scale on-demand micropatterning of gelatin hydrogels for organ-on-chip applications using a novel biocompatible laser-etching approach...
January 16, 2018: Biofabrication
https://www.readbyqxmd.com/read/29310227/quantitative-analysis-of-drug-distribution-by-ambient-mass-spectrometry-imaging-method-with-signal-extinction-normalization-strategy-and-inkjet-printing-technology
#13
Zhigang Luo, Jingjing He, Jiuming He, Lan Huang, Xiaowei Song, Xin Li, Zeper Abliz
Quantitative mass spectrometry imaging (MSI) is a robust approach that provides both quantitative and spatial information for drug candidates' research. However, because of complicated signal suppression and interference, acquiring accurate quantitative information from MSI data remains a challenge, especially for whole-body tissue sample. Ambient MSI techniques using spray-based ionization appear to be ideal for pharmaceutical quantitative MSI analysis. However, it is more challenging, as it involves almost no sample preparation and is more susceptible to ion suppression/enhancement...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29310212/an-electrochemical-immunosensor-for-brain-natriuretic-peptide-prepared-with-screen-printed-carbon-electrodes-nanostructured-with-gold-nanoparticles-grafted-through-aryl-diazonium-salt-chemistry
#14
V Serafín, R M Torrente-Rodríguez, A González-Cortés, P García de Frutos, M Sabaté, S Campuzano, P Yáñez-Sedeño, J M Pingarrón
A sensitive amperometric immunosensor has been prepared by immobilization of capture antibodies onto gold nanoparticles (AuNPs) grafted on a screen-printed carbon electrode (SPCE) through aryl diazonium salt chemistry using 4-aminothiophenol (AuNPs-S-Phe-SPCE). The immunosensor was designed for the accurate determination of clinically relevant levels of B-type natriuretic peptide (BNP) in human serum samples. The nanostructured electrochemical platform resulted in an ordered layer of AuNPs onto SPCEs which combined the advantages of high conductivity and improved stability of immobilized biomolecules...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29305642/feasibility-and-validity-of-printing-3d-heart-models-from-rotational-angiography
#15
Manoj Parimi, John Buelter, Vignan Thangundla, Sri Condoor, Nadeem Parkar, Saar Danon, Wilson King
Rotational angiography (RA) has proven to be an excellent method for evaluating congenital disease (CHD) in the cardiac cath lab, permitting acquisition of 3D datasets with superior spatial resolution. This technique has not been routinely implemented for 3D printing in CHD. We describe our case series of models printed from RA and validate our technique. All patients with models printed from RA were selected. RA acquisitions from a Toshiba Infinix-I system were postprocessed and printed with a Stratasys Eden 260...
January 5, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29277300/innovations-in-preoperative-planning-insights-into-another-dimension-using-3d-printing-for-cardiac-disease
#16
REVIEW
Kanwal M Farooqi, Feroze Mahmood
Two-dimensional visualization of complex congenital heart disease has limitations in that there is variation in the interpretation by different individuals. Three-dimensional printing technology has been in use for decades but is currently becoming more commonly used in the medical field. Congenital heart disease serves as an ideal pathology to employ this technology because of the variation of anatomy between patients. In this review, the authors aim to discuss basics of applicability of three-dimensional printing, the process involved in creating a model, as well as challenges with establishing utility and quality...
November 23, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29239855/experimental-verification-of-stopping-power-prediction-from-single-and-dual-energy-computed-tomography-in-biological-tissues
#17
Christian Möhler, Tom Russ, Patrick Wohlfahrt, Alina Elter, Armin Runz, Christian Richter, Steffen Greilich
An experimental setup for consecutive measurement of ion and x-ray absorption in tissue or other materials is introduced. With this setup using a 3D-printed sample container, the reference stopping-power ratio (SPR) of materials can be measured with an uncertainty of below 0.1%. A total of 65 porcine and bovine tissue samples were prepared for measurement, comprising five samples each of 13 tissue types representing about 80% of the total body mass (three different muscle and fatty tissues, liver, kidney, brain, heart, blood, lung and bone)...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29232300/three-dimensional-printing-of-life-like-models-for-simulation-and-training-of-minimally-invasive-cardiac-surgery
#18
Toshiyuki Yamada, Motohiko Osako, Tomoya Uchimuro, Ryogen Yoon, Toshiaki Morikawa, Maki Sugimoto, Hisao Suda, Hideyuki Shimizu
OBJECTIVE: As the use of minimally invasive surgery in cardiothoracic surgery increases, so does the need for simulation and training. We developed a heart model for simulation and training of minimally invasive cardiac surgery, particularly minimally invasive mitral valve repair using our new three-dimensional printing system. METHODS: Digital imaging and communication in medicine data from patient computed tomography, three-dimensional computer-aided design, and three-dimensional printing helped create replicas of the heart and thoracic cavity...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29231093/the-utility-of-simulation-in-the-management-of-patients-with-congenital-heart-disease-past-present-and-future
#19
Ali Subat, Andrew Goldberg, Samuel Demaria, Daniel Katz
Significant advancements have been made in the diagnosis and management of congenital heart disease (CHD). As a result, a higher percentage of these patients are surviving to adulthood. Despite this improvement in management, these patients remain at higher risk of morbidity and mortality, particularly in the perioperative setting. One new area of interest in these patients is the implementation of simulation-based medical education. Simulation has demonstrated various benefits across high-acuity scenarios encountered in the hospital...
December 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29223704/decellularized-heart-ecm-hydrogel-using-supercritical-carbon-dioxide-for-improved-angiogenesis
#20
Yoojin Seo, Youngmee Jung, Soo Hyun Kim
Initial angiogenesis within the first 3 days is critical for healing ischemic diseases such as myocardial infarction. Recently, decellularized extracellular matrix (dECM) has been reported to provide tissue-derived ECM components and can be used as a scaffold for cell delivery for angiogenesis in tissue engineering. Decellularization by various detergents such as sodium dodecyl sulfate (SDS) and triton X-100 can remove the cell nuclei in tissue organs. However, this leads to ECM structure denaturation, decreased presence of various ECM proteins and cytokines, and loss of mechanical properties...
December 6, 2017: Acta Biomaterialia
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