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Global radiation oncology

Mallory E Carson, Andrea Molineu, Paige A Taylor, David S Followill, Francesco C Stingo, Stephen F Kry
PURPOSE: To analyze the most recent results of the Imaging and Radiation Oncology Core Houston Quality Assurance Center's (IROC-H) anthropomorphic head and neck (H&N) phantom to determine the nature of failing irradiations and the feasibility of altering credentialing criteria. METHODS: IROC-H's H&N phantom, used for intensity-modulated radiation therapy credentialing for National Cancer Institute-sponsored clinical trials, requires that an institution's treatment plan agrees within ±7% of measured thermoluminescent dosimeter (TLD) doses; it also requires that ≥85% of pixels pass ±4 mm distance to agreement (7%/4 mm gamma analysis for film)...
December 2016: Medical Physics
Elena Leinert, Susanne Singer, Wolfgang Janni, Nadia Harbeck, Tobias Weissenbacher, Brigitte Rack, Doris Augustin, Arthur Wischnik, Marion Kiechle, Johannes Ettl, Visnja Fink, Lukas Schwentner, Martin Eichler
BACKGROUND: Elderly breast cancer patients are affected by poorer quality of life (QoL) compared to younger patients. Because QoL has a relevant impact on guideline-adherent treatment, elderly breast cancer patients are often undertreated, especially with regard to adjuvant chemotherapy, and overall survival is decreased. Thus, understanding the impact of chemotherapy on QoL in elderly patients is crucial. This study compared QoL in patients aged < 65 years and 65 to 70 years receiving adjuvant chemotherapy as a secondary outcome in the prospective randomized multicenter ADEBAR trial...
October 19, 2016: Clinical Breast Cancer
Olivier D R van Wulfften Palthe, Stein J Janssen, Jay S Wunder, Peter C Ferguson, Guo Wei, Peter S Rose, Micheal J Yaszemski, Franklin H Sim, Patrick J Boland, John H Healey, Francis J Hornicek, Joseph H Schwab
BACKGROUND CONTEXT: Patient reported outcomes are becoming increasingly important when investigating results of patient and disease management. In sacral tumor patients symptoms can vary substantially, therefore no single questionnaire can adequately account for the full spectrum of symptoms and disability. PURPOSE: The purpose of this study is to analyze redundancy within the current sacral tumor survey and make a recommendation for an updated version based on the results and patient and expert opinions...
November 14, 2016: Spine Journal: Official Journal of the North American Spine Society
Cengiz Gemici, Gokhan Yaprak, Hasan Fevzi Batirel, Mahmut Ilhan, Alpaslan Mayadagli
BACKGROUND: Locoregional recurrence is a major problem in esophageal cancer patients treated with definitive concomitant chemoradiotherapy. Approximately half of the patients fail locoregionally. We analyzed the impact of enlarged radiation field size and higher radiation dose incorporated to chemoradiotherapy on oncologic outcome. METHODS: Seventy-four consecutive patients with histologically proven nonmetastatic squamous or adenocarcinoma of the esophagus were included in this retrospective analysis...
October 13, 2016: World Journal of Surgical Oncology
Paola Friedrich, Catherine G Lam, Geetinder Kaur, Elena Itriago, Raul C Ribeiro, Ramandeep S Arora
BACKGROUND: Understanding and addressing treatment abandonment (TxA) is crucial for bridging the pediatric cancer survival gap between high-income (HIC) and low-and middle-income countries (LMC). In childhood cancer, TxA is defined as failure to start or complete curative cancer therapy and known to be a complex phenomenon. With rising interest on causes and consequences of TxA in LMC, this study aimed to establish the lay-of-the-land regarding determinants of TxA globally, perform and promote comparative research, and raise awareness on this subject...
2016: PloS One
Byeongsang Oh, Thomas Eade, Andrew Kneebone, Nick Pavlakis, Stephen Clarke, Guy Eslick, Jo River, Michael Back
OBJECTIVE: To explore the factors associated with utilisation of an acupuncture service in a tertiary oncology setting in an Australian public hospital. METHOD: Cancer patients attending oncology clinics at a university teaching hospital were invited to participate in the evaluation of acupuncture services from June 2014 to May 2015. Patients had a prior diagnosis of cancer (albeit at different stages) and were planning to receive, or were already receiving, systemic and/or radiation cancer treatment...
September 22, 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Berardino De Bari, Stefano Arcangeli, Delia Ciardo, Rosario Mazzola, Filippo Alongi, Elvio G Russi, Riccardo Santoni, Stefano M Magrini, Barbara A Jereczek-Fossa
The aim of this review is to present the available radiobiological, technical and clinical data about extreme hypofractionation in primary prostate cancer radiotherapy. The interest in this technique is based on the favourable radiobiological characteristics of prostate cancer and supported by advantageous logistic aspects deriving from short overall treatment time. The clinical validity of short-term treatment schedule is proven by a body of non-randomised studies, using both isocentric (LINAC-based) or non-isocentric (CyberKnife(®)-based) stereotactic body irradiation techniques...
August 29, 2016: Cancer Treatment Reviews
Wendy J Bottinor, Christopher K Migliore, Carrie A Lenneman, Marcus F Stoddard
Patients with cancer can present with difficult management issues, as the medicine can sometimes cause sequelae destructive to healthy tissue. As this population lives longer, cardiotoxic effects are beginning to emerge, but the early recognition of this signal can prove difficult, with too late a recognition leading to lifelong cardiac impairment and dysfunction. Cardio-oncology can bridge this difficulty, and echocardiography and its newer imaging abilities are proving efficacious in this population. This article will address common sequelae of cardiotoxic treatment regimens and offer recommendations for echocardiographic surveillance...
October 2016: Current Cardiology Reports
Vivek Verma, Charles B Simone, Andrew O Wahl, Sushil Beriwal, Minesh P Mehta
BACKGROUND: Proton beam therapy (PBT) is increasingly being used globally to treat a variety of malignancies. This is the first review assessing PBT for gynecologic neoplasms. Dose distribution to organs-at-risk (OARs), particularly bone marrow (BM), is addressed. Clinical outcomes and toxicity data are detailed. MATERIAL AND METHODS: Systematic searches of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology were conducted for publications...
November 2016: Acta Oncologica
Niloy Ranjan Datta, Shaka Khan, Dietmar Marder, Daniel Zwahlen, Stephan Bodis
PURPOSE: The purpose of this study was to evaluate the present status of radiotherapy infrastructure and human resources in Switzerland and compute projections for 2020. MATERIALS AND METHODS: The European Society of Therapeutic Radiation Oncology "Quantification of Radiation Therapy Infrastructure and Staffing" guidelines (ESTRO-QUARTS) and those of the International Atomic Energy Agency (IAEA) were applied to estimate the requirements for teleradiotherapy (TRT) units, radiation oncologists (RO), medical physicists (MP) and radiotherapy technologists (RTT)...
September 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Thomas C Randall, Rahel Ghebre
Virtually all cases of invasive cervical cancer are associated with infection by high-risk strains of human papilloma virus. Effective primary and secondary prevention programs, as well as effective treatment for early-stage invasive cancer have dramatically reduced the burden of cervical cancer in high-income countries; 85% of the mortality from cervical cancer now occurs in low- and middle-income countries. This article provides an overview of challenges to cervical cancer care in sub-Saharan Africa (SSA) and identifies areas for programmatic development to meet the global development goal to reduce cancer-related mortality...
2016: Frontiers in Oncology
Brigid E Hickey, Melissa L James, Margot Lehman, Phil N Hider, Mark Jeffery, Daniel P Francis, Adrienne M See
BACKGROUND: Shortening the duration of radiation therapy would benefit women with early breast cancer treated with breast conserving surgery. It may also improve access to radiation therapy by improving efficiency in radiation oncology departments globally. This can only happen if the shorter treatment is as effective and safe as conventional radiation therapy. This is an update of a Cochrane Review first published in 2008 and updated in 2009. OBJECTIVES: To assess the effect of altered radiation fraction size for women with early breast cancer who have had breast conserving surgery...
2016: Cochrane Database of Systematic Reviews
Linus T Chuang, Thomas C Randall, Lynette Denny, Carolyn M Johnston, Kathleen M Schmeler, Allan L Covens, David Cibula, Michael A Bookman, Sudhir Rawal, Denny DePetrillo, Joo-Hyun Nam, Annekathryn Goodman, Raj Naik, Ranjit Manchanda, David K Gaffney, William Small, Carien Creutzberg, Carole Rattray, Vesna Kesic, René Paraja, Mary Eiken, Kristin Belleson, Robert L Coleman, Richard R Barakat, Edward L Trimble, Michael Quinn
OBJECTIVES: To identify common barriers to teaching and training and to identify strategies that would be useful in developing future training programs in gynecologic oncology in low- and middle- income countries. METHODS: There is a lack of overall strategy to meet the needs of education and training in gynecologic oncology in low- and middle- income countries, the leaderships of sister societies and global health volunteers met at the European Society of Gynecologic Oncology in October 23, 2015...
July 2016: International Journal of Gynecological Cancer
Reinhard R Beichel, Markus Van Tol, Ethan J Ulrich, Christian Bauer, Tangel Chang, Kristin A Plichta, Brian J Smith, John J Sunderland, Michael M Graham, Milan Sonka, John M Buatti
PURPOSE: The purpose of this work was to develop, validate, and compare a highly computer-aided method for the segmentation of hot lesions in head and neck 18F-FDG PET scans. METHODS: A semiautomated segmentation method was developed, which transforms the segmentation problem into a graph-based optimization problem. For this purpose, a graph structure around a user-provided approximate lesion centerpoint is constructed and a suitable cost function is derived based on local image statistics...
June 2016: Medical Physics
Sandrine Censabella, Stefan Claes, Jolien Robijns, Paul Bulens, Jeroen Mebis
PURPOSE: The aim of this study was to assess the effectiveness and acceptability of photobiomodulation using MLS(®) laser therapy (LT) in the management of acute radiation dermatitis (RD). METHODS: We compared two successive groups of breast cancer patients undergoing identical radiotherapy regimens post-lumpectomy. Both groups received our standard skin care but the second group received six additional LT sessions (beam area 19.635 cm(2), 0.168 W/cm(2), 4 J/cm(2)), starting at fraction 20 of radiotherapy (control and LT group, N = 41 and 38, respectively)...
September 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Yuji Ikeda, Akiko Furusawa, Ryo Kitagawa, Aya Tokinaga, Fuminori Ito, Masayo Ukita, Hidetaka Nomura, Wataru Yamagami, Hiroshi Tanabe, Mikio Mikami, Nobuhiro Takeshima, Nobuo Yaegashi
OBJECTIVE: Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of adjuvant therapy for intermediate/high-risk cervical cancer after radical surgery in Japan. METHODS: A questionnaire survey was conducted by the Japanese Gynecologic Oncology Group to 186 authorized institutions active in the treatment of gynecologic cancer...
May 2016: Journal of Gynecologic Oncology
Andre Konski, James B Yu, Gary Freedman, Louis B Harrison, Peter A S Johnstone
PURPOSE: Use of hypofractionation is increasing in radiation oncology because of several factors. The effects of increasing hypofractionation use on departments and staff currently based on fee-for-service models are not well studied. METHODS: We modeled the effects of moving to hypofractionation for prostate, breast, and lung cancer and palliative treatments in a typical-sized hospital-based radiation oncology department. Year 2015 relative value unit (RVU) data were used to determine changes in reimbursement...
May 2016: Journal of Oncology Practice
L Spotten, C Corish, C Lorton, P Ui Dhuibhir, N O'Donoghue, B O'Connor, M Cunningham, N El Beltagi, C Gillham, D Walsh
PURPOSE: Taste and smell changes (TSCs) are common in head and neck (H&N) cancer and during and after chemotherapy (CT) and radiotherapy (RT). It is an area that has been under-investigated, particularly in the treatment-naive, but can negatively impact nutritional status. This study examined the prevalence, severity and characteristics of TSCs in people with non-H&N solid tumours, before CT and RT, and their relationship with co-occurring symptoms. METHODS: A prospective, observational study was conducted...
July 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ramon E Jimenez, Lindsay Hollander, Timothy Boyd
UNLABELLED: Accelerated partial breast irradiation via brachytherapy (APBI-b) is offered as an alternative to whole breast irradiation (WBI) for selected patients with breast cancer. This study evaluates our clinical experience with APBI-b to identify the reasons for decreased clinical utilization in recent years. We performed an analysis of the prospective database of breast cancer patients treated with APBI-b between 2004 and 2013. During that time, 245 patients received APBI-b, most having stage I (77%) or stage 0 (20%) breast cancer...
January 2016: Connecticut Medicine
Wilfred Ngwa, Twalib Ngoma, Anthony Zietman, Nina Mayr, Ahmed Elzawawy, Thomas A Winningham, Onyinye Balogun, Nelly Enwerem-Bromson, Christian Ntizimira, Olufunmilayo I Olopade, Doyin Oluwole, Folakemi Odedina, Makeda Williams, John Flanigan, Lydia Asana, Kenneth Ngwa, Stephen Avery, Julianne M Pollard, Teboh Roland, Neba Funwi-gabga, Victor Mbarika, Patricia Hardenbergh, Karen Winkfield, Yakov Pipman, Christina Stefan, Mamsau Ngoma, Sulma Mohammed, Matthew Katz, Sajo Erno, Janaki Moni, Thomas Fitzgerald, Nathan Tonlaar, Jason Efstathiou, David Gierga, Charles Ayo, Felicia Knaul, Mary Gospodarowicz, G Mike Makrigiorgos, Paul L Nguyen
No abstract text is available yet for this article.
March 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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