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International radiation oncology

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https://www.readbyqxmd.com/read/29126815/analysis-of-suicide-risk-in-patients-with-penile-cancer-and-review-of-the-literature
#1
REVIEW
William G Simpson, Zachary Klaassen, Rita P Jen, William M Hughes, Durwood E Neal, Martha K Terris
The treatment for penile cancer has been shown to cause harmful psychiatric symptoms as well as have detrimental effects on well-being. In the past several years, alternatives to total or partial penectomy have emerged, such as chemotherapy, radiation, penile sparing, and laser ablation therapies. A more specific breakdown for penile cancer is in order as the therapy has the potential for life changing surgery. We examined the Surveillance, Epidemiology, and End Results (SEER) database (1973-2013), comprising 28% of the United States population...
October 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29105051/tumour-bed-boost-radiotherapy-for-women-after-breast-conserving-surgery
#2
REVIEW
Isabelle Kindts, Annouschka Laenen, Tom Depuydt, Caroline Weltens
BACKGROUND: Breast-conserving therapy, involving breast-conserving surgery followed by whole-breast irradiation and optionally a boost to the tumour bed, is a standard therapeutic option for women with early-stage breast cancer. A boost to the tumour bed means that an extra dose of radiation is applied that covers the initial tumour site. The rationale for a boost of radiotherapy to the tumour bed is that (i) local recurrence occurs mostly at the site of the primary tumour because remaining microscopic tumour cells are most likely situated there; and (ii) radiation can eliminate these causative microscopic tumour cells...
November 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29069831/stereotactic-ablative-body-radiotherapy-for-spinal-metastasis-from-hepatocellular-carcinoma-its-oncologic-outcomes-and-risk-of-vertebral-compression-fracture
#3
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu, Do Hoon Lim, Won Kyung Cho, Eonju Lee, Sang Hoon Jung, Youngyih Han, Eun-Sang Kim, Sun-Ho Lee, Whan Eoh, Se-Jun Park, Sung-Soo Chung, Chong-Suh Lee, Joon Hyuk Lee
Spinal metastases from hepatocellular carcinoma (HCC) require high-dose irradiation for durable pain and tumor control. Stereotactic ablative body radiotherapy (SABR) enables the delivery of high-dose radiation. However, but vertebral compression fracture (VCF) can be problematic. The aim of his study is to evaluate the outcome and risk of VCF after SABR for spinal metastasis from HCC. We retrospectively reviewed 33 lesions in 42 spinal segments from 29 patients who received SABR with 1 fraction (16-20 Gy), or 3 fractions (18-45 Gy) from September 2009 to January 2015...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045519/reply-to-the-st-gallen-international-expert-consensus-on-the-primary-therapy-of-early-breast-cancer-2017-the-point-of-view-of-an-international-panel-of-experts-in-radiation-oncology-by-kirova-et-al
#4
G Curigliano, H J Burstein, E P Winer, M Gnant, P Dubsky, S Loibl, M Colleoni, M M Regan, M Piccart-Gebhart, H-J Senn, B Thürlimann, F André, J Baselga, J Bergh, H Bonnefoi, S Y Brucker, F Cardoso, L Carey, E Ciruelos, J Cuzick, C Denkert, A Di Leo, B Ejlertsen, P Francis, V Galimberti, J Garber, B Gulluoglu, P Goodwin, N Harbeck, D F Hayes, C-S Huang, J Huober, H Khaled, J Jassem, Z Jiang, Per Karlsson, M Morrow, R Orecchia, K C Osborne, O Pagani, A H Partridge, K Pritchard, J Ro, E J T Rutgers, F Sedlmayer, V Semiglazov, Z Shao, I Smith, M Toi, A Tutt, G Viale, T Watanabe, T J Whelan, B Xu
No abstract text is available yet for this article.
September 25, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045510/the-st-gallen-international-expert-consensus-on-the-primary-therapy-of-early-breast-cancer-2017-the-point-of-view-of-an-international-panel-of-experts-in-radiation-oncology
#5
Y M Kirova, S Carroll, A Fourquet, B Offersen, C Aristei, J-Y Chen
No abstract text is available yet for this article.
September 22, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28974597/selective-internal-radiation-therapy-for-liver-tumours
#6
Francis X Sundram, John R Buscombe
Primary and secondary liver malignancies are common and associated with a poor prognosis. Surgical resection is the treatment of choice; however, many patients have unresectable disease. In these cases, several liver directed therapies are available, including selective internal radiation therapy (SIRT). SIRT is a multidisciplinary treatment involving nuclear medicine, interventional radiology and oncology. High doses of localised internal radiation are selectively delivered to liver tumour tissues, with relative sparing of adjacent normal liver parenchyma...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28967564/multidisciplinary-international-survey-of-post-operative-radiation-therapy-practices-after-nipple-sparing-or-skin-sparing-mastectomy
#7
Gustavo Nader Marta, Philip Poortmans, Alfredo C de Barros, José Roberto Filassi, Ruffo Freitas Junior, Riccardo A Audisio, Max Senna Mano, Sarkis Meterissian, Sarah M DeSnyder, Thomas A Buchholz, Tarek Hijal
PURPOSE/OBJECTIVE(S): Skin sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) have entered routine surgical practice for breast cancer, though their oncologic safety has not been established in randomized controlled trials. The aim of this study was to evaluate and compare radiation oncologists' and breast surgeons' opinions concerning the indications of post-operative radiation therapy (PORT) after SSM and NSM. MATERIALS/METHODS: Radiation oncologists and breast surgeons from North America, South America and Europe were invited to contribute in this study...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28959507/a-regional-multicenter-retrospective-analysis-of-patients-with-primary-central-nervous-system-lymphoma-diagnosed-from-2000-2012-treatment-patterns-and-clinical-outcomes
#8
Eric C Burton, Beatrice Ugiliweneza, Murali K Kolikonda, Tanuj Saaraswat, Shiao Woo, Maxwell Boakye, Lennea Coombs, Renato LaRocca, Aaron Spalding
Introduction Primary central nervous system lymphoma (PCNSL) is a rare tumor without a well-defined standard of care. For immunocompetent patients, therapeutic regimens have largely evolved from treatment with whole-brain radiation therapy (WBRT) to treating initially with systemic chemotherapy regimens that include high-dose (HD) methotrexate (MTX) with or without WBRT. Looking at population-based treatment trends may help define which therapies are most effective. This study was conducted to determine treatment patterns and outcomes for patients with PCNSL in the Louisville, KY metropolitan area during the period 2000 to 2012...
July 25, 2017: Curēus
https://www.readbyqxmd.com/read/28927756/recent-time-trends-and-predictors-of-heart-dose-from-breast-radiation-therapy-in-a-large-quality-consortium-of-radiation-oncology-practices
#9
Lori J Pierce, Mary Feng, Kent A Griffith, Reshma Jagsi, Thomas Boike, Daniel Dryden, Gregory S Gustafson, Lisa Benedetti, Martha M Matuszak, Teamour S Nurushev, Joe Haywood, Jeffrey D Radawski, Corey Speers, Eleanor M Walker, James A Hayman, Jean M Moran
PURPOSE: Limited data exist regarding the range of heart doses received in routine practice with radiation therapy (RT) for breast cancer in the United States today and the potential effect of the continual assessment of the cardiac dose on practice patterns. METHODS AND MATERIALS: From 2012 to 2015, 4688 patients with breast cancer treated with whole breast RT at 20 sites participating in a state-wide consortium were enrolled into a registry. The importance of limiting the cardiac dose has been emphasized in the consortium since 2012, and the mean heart dose (MHD) has been reported by each institution since 2014...
July 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28913177/big-data-in-designing-clinical-trials-opportunities-and-challenges
#10
Charles S Mayo, Martha M Matuszak, Matthew J Schipper, Shruti Jolly, James A Hayman, Randall K Ten Haken
Emergence of big data analytics resource systems (BDARSs) as a part of routine practice in Radiation Oncology is on the horizon. Gradually, individual researchers, vendors, and professional societies are leading initiatives to create and demonstrate use of automated systems. What are the implications for design of clinical trials, as these systems emerge? Gold standard, randomized controlled trials (RCTs) have high internal validity for the patients and settings fitting constraints of the trial, but also have limitations including: reproducibility, generalizability to routine practice, infrequent external validation, selection bias, characterization of confounding factors, ethics, and use for rare events...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28911068/early-stage-mantle-cell-lymphoma-a-retrospective-analysis-from-the-international-lymphoma-radiation-oncology-group-ilrog
#11
B S Dabaja, A D Zelenetz, A K Ng, R W Tsang, S Qi, P K Allen, D Hodgson, U Ricardi, R T Hoppe, R Advani, P M Mauch, L S Constine, L Specht, Y Li, S A Terezakis, A Wirth, G Reinartz, H T Eich, B M P Aleman, P Barr, J Yahalom
Background: Mantle cell lymphoma (MCL) rarely presents as early-stage disease, but clinical observations suggest that patients who present with early-stage disease may have better outcomes than those with advanced-stage disease. Patients and methods: In this 13-institution study, we examined outcomes among 179 patients with early-stage (stage I or II) MCL in an attempt to identify prognostic factors that influence treatment selection and outcome. Variables examined included clinical characteristics, treatment modality, response to therapy, sites of failure, and survival...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28865683/evaluation-of-near-miss-and-adverse-events-in-radiation-oncology-using-a-comprehensive-causal-factor-taxonomy
#12
Matthew B Spraker, Robert Fain, Olga Gopan, Jing Zeng, Matthew Nyflot, Loucille Jordan, Gabrielle Kane, Eric Ford
PURPOSE: Incident learning systems (ILSs) are a popular strategy for improving safety in radiation oncology (RO) clinics, but few reports focus on the causes of errors in RO. The goal of this study was to test a causal factor taxonomy developed in 2012 by the American Association of Physicists in Medicine and adopted for use in the RO: Incident Learning System (RO-ILS). METHODS AND MATERIALS: Three hundred event reports were randomly selected from an institutional ILS database and Safety in Radiation Oncology (SAFRON), an international ILS...
September 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28864405/ischemic-cardiac-events-following-treatment-of-the-internal-mammary-nodal-region-using-contemporary-radiation-planning-techniques
#13
Robert T Dess, Adam L Liss, Kent A Griffith, Robin B Marsh, Jean M Moran, Charles Mayo, Todd M Koelling, Reshma Jagsi, James A Hayman, Lori J Pierce
PURPOSE: Regional nodal irradiation, including radiation therapy (RT) to the internal mammary node (IMN) region, improves oncologic outcomes in patients with node-positive breast cancer. Concern remains, however, given the proximity of the IMNs to the heart and the association between cardiac RT exposure and toxicity. The objective of the study was to evaluate rates of ischemic cardiac events (ICEs) and associated risk with treatment of the IMN region. METHODS AND MATERIALS: The cardiac outcomes of 2126 patients treated with adjuvant breast RT or breast and nodal RT from 1984 to 2007 at a single institution were reviewed...
June 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28862111/how-can-we-improve-education-of-breast-surgeons-across-europe
#14
Agnieszka Kolacinska
The proposed global curriculum developed by the American Society of Surgical Oncology (SSO) and the European Society of Surgical Oncology (ESSO) and the textbook: provides a state-of- the- art of breast cancer surgery, complements the syllabus and curriculum of the Union Europeenne des Medecins Specialistes (UEMS) examination in breast surgery/ European Board of Surgery Qualification in Breast Surgery (EBSQinBS) administered by ESSO (1) Knowledge and understanding of the principles of breast cancer incidence, aetiology, risk factors, genetics, premalignant and high-risk lesions, pathology, prognostic and predictive factors, risk prediction models, screening, diagnosis and imaging, breast cancer, oncoplastic, reconstructive breast surgery, axillary surgery and future perspective for this, radiation therapy, neoadjuvant and adjuvant systemic treatment- endocrine-, immuno- and chemotherapy, side effects and toxicities of treatment, locoregional recurrence, follow-up, locally advanced breast cancer, metastatic breast cancer, breast cancer in young and elderly patients, survivor issues, lymphedema, palliative care, chroni pain, body image and sexuality, fertility issues, cognitive functions, etc...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28845050/preservation-of-fertility-or-ovarian-function-in-patients-with-breast-cancer-or-gynecologic-and-internal-malignancies
#15
Angrit Stachs, Steffi Hartmann, Bernd Gerber
Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28843380/the-impact-of-intensity-modulated-radiation-therapy-plan-normalization-in-the-postprostatectomy-setting-does-it-matter
#16
Mary Anne Stritch, Elizabeth Forde, Michelle Leech
The International Commission on Radiation Units & Measurements -83 recommends prescribing intensity-modulated radiation therapy (IMRT) in a dose-volume manner. Despite this, clinical variation still exists in how prostate IMRT plans are prescribed. This study aims to investigate the impact of different plan normalization methods for postprostatectomy IMRT. IMRT treatment plans were created retrospectively for 20 postprostatectomy patients. These were normalized such that the dose received by 98% (D98) of the planning target volume (PTV) was equal to 100% of the prescribed dose...
August 23, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28831281/improving-radiation-oncology-through-clinical-audits-introducing-the-iroca-project
#17
Maria Glòria Torras, Magdalena Fundowicz, Luisa Aliste, Esther Asensio, Anna Maria Boladeras, Josep Maria Borràs, Luísa Carvalho, Carla Castro, Letizia Deantonio, Ewelina Konstanty, Marco Krengli, Marta Kruszyna, Joana Lencart, Miquel Macià, Susanna Marín, Carles Muñoz-Montplet, Carla Pisani, Diana Pinto, Montserrat Puigdemont, Ferran Guedea, Artur Aguiar, Piotr Milecki, Julian Malicki
As radiotherapy practice and processes become more complex, the need to assure quality control becomes ever greater. At present, no international consensus exists with regards to the optimal quality control indicators for radiotherapy; moreover, few clinical audits have been conducted in the field of radiotherapy. The present article describes the aims and current status of the international IROCA "Improving Radiation Oncology Through Clinical Audits" project. The project has several important aims, including the selection of key quality indicators, the design and implementation of an international audit, and the harmonization of key aspects of radiotherapy processes among participating institutions...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28821268/hypo-fractionated-sbrt-for-localized-prostate-cancer-a-german-bi-center-single-treatment-group-feasibility-trial
#18
Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S Merseburger, Alan Katz, Andreas Ziegler, Oliver Blanck, Jürgen Dunst
BACKGROUND: For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionation over 8 weeks or with moderate hypo-fractionation over about 5 weeks. Recent advances in radiotherapy technology have made extreme hypo-fractionated stereotactic body radiation therapy (SBRT) of prostate cancer feasible, which has not yet been introduced as a standard treatment method in Germany...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28807698/-cross-cultural-adaptation-and-psychometric-evaluation-of-the-turkish-version-of-the-cancer-behavior-inventory-brief-version
#19
Emine Iyigun, Sevinc Tastan, Elif Gezginci, Serap Korkmaz, Selcuk Demiral, Murat Beyzadeoglu
CONTEXT: Cancer Behavior Inventory-Brief Version is a simple and non-burdensome tool used to evaluate the self-efficacy of the cancer patients. OBJECTIVES: The aim of this study was to examine the psychometric properties of the Turkish version of the Cancer Behavior Inventory-Brief Version. METHODS: This methodological study was conducted on 143 cancer patients who received radiotherapy at the Department of Radiation Oncology at a Training and Research Hospital in Turkey...
August 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28777690/development-and-validation-of-nomograms-predictive-of-overall-and-progression-free-survival-in-patients-with-oropharyngeal-cancer
#20
Carole Fakhry, Qiang Zhang, Phuc Felix Nguyen-Tân, David I Rosenthal, Randal S Weber, Louise Lambert, Andy M Trotti, William L Barrett, Wade L Thorstad, Christopher U Jones, Sue S Yom, Stuart J Wong, John A Ridge, Shyam S D Rao, James A Bonner, Eric Vigneault, David Raben, Mahesh R Kudrimoti, Jonathan Harris, Quynh-Thu Le, Maura L Gillison
Purpose Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification of therapeutic intensity, which requires patient-specific estimates of overall survival (OS) and progression-free survival (PFS). Methods To develop and validate nomograms for OS and PFS, we used a derivation cohort of 493 patients with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation Therapy Oncology Group [RTOG] 0129 and 0522)...
August 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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