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International radiation oncology

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https://www.readbyqxmd.com/read/27884041/follow-up-strategies-for-patients-treated-for-non-metastatic-colorectal-cancer
#1
REVIEW
Mark Jeffery, Brigid E Hickey, Phil N Hider, Adrienne M See
BACKGROUND: It is common clinical practice to follow patients with colorectal cancer (CRC) for several years following their curative surgery or adjuvant therapy, or both. Despite this widespread practice, there is considerable controversy about how often patients should be seen, what tests should be performed, and whether these varying strategies have any significant impact on patient outcomes. This is the second update of a Cochrane Review first published in 2002 and first updated in 2007...
November 24, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27867823/the-burden-of-metastatic-disease-of-the-femur-on-the-medicare-system
#2
Kirollos Gendi, David Hennessy, John Heiner
BACKGROUND: In the United States, over 1,650,000 new cases of cancer are being diagnosed yearly with almost 50 % of them being the top five bone-seeking cancers. Since cancer risk increases with age, this suggests that orthopedic oncology services may be a strain on the Medicare system. The femur is the most common site of long bone metastases. Prophylactic fixation techniques prevent pathologic fractures, reduce morbidities, and enhance the quality of life of patients with femoral metastases...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27856381/what-questionnaires-to-use-when-measuring-quality-of-life-in-sacral-tumor-patients-the-updated-sacral-tumor-survey
#3
Olivier D R van Wulfften Palthe, Stein J Janssen, Jay S Wunder, Peter C Ferguson, Guo Wei, Peter S Rose, Micheal J Yaszemski, Franklin H Sim, Patrick J Boland, John H Healey, Francis J Hornicek, Joseph H Schwab
BACKGROUND CONTEXT: Patient reported outcomes are becoming increasingly important when investigating results of patient and disease management. In sacral tumor patients symptoms can vary substantially, therefore no single questionnaire can adequately account for the full spectrum of symptoms and disability. PURPOSE: The purpose of this study is to analyze redundancy within the current sacral tumor survey and make a recommendation for an updated version based on the results and patient and expert opinions...
November 14, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27847135/medical-physics-challenges-for-the-implementation-of-quality-assurance-programmes-in-radiation-oncology
#4
A Meghzifene
The importance of quality assurance in radiation therapy, as well as its positive consequences on patient treatment outcome, is well known to radiation therapy professionals. In low- and middle-income countries, the implementation of quality assurance in radiation therapy is especially challenging, due to a lack of staff training, a lack of national guidelines, a lack of quality assurance equipment and high patient daily throughput. According to the International Atomic Energy Agency (IAEA) Directory of Radiotherapy Centres, the proportion of linear accelerators compared with Co-60 machines has increased significantly in recent years in low- and middle-income countries...
November 12, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27842711/-radiation-related-heart-toxicity-update-in-women
#5
S Marlière, E Vautrin, C Saunier, A Chaikh, I Gabelle-Flandin
Breast cancer is a common diagnosis in women and thus women are at risk of radiation-induced heart disease, in particular during radiotherapy for left breast cancer and when the internal mammary chain is included. Rates of major cardiac events increase with younger age at the time of irradiation, diagnosis before 1990s, higher radiation doses, coexisting cardiovascular risk factors and adjuvant cardiotoxic chemotherapy. Radiation-induced heart disease comprises a spectrum of cardiac pathologies, including pericardial disease, cardiomyopathy, coronary artery disease and valvular disease...
November 11, 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27816540/frequency-of-whole-breast-radiation-therapy-after-intraoperative-radiation-therapy-due-to-criteria-identified-by-lumpectomy
#6
Eric A Mellon, Amber Orman, Luis E Joya, Michael E Montejo, Christine Laronga, Susan J Hoover, M Catherine Lee, Nazanin Khakpour, Pamela F Kubal, Roberto Diaz
PURPOSE: For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor identification rates triggering WBRT recommendation, we analyzed adverse prognostic features based on multiple international criteria for suitability for accelerated partial breast irradiation...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27816539/feasibility-study-of-toxicity-outcomes-using-gec-estro-contouring-guidelines-on-ct-based-instead-of-mri-based-planning-in-locally-advanced-cervical-cancer-patients
#7
Vicky Koh, Bok Ai Choo, Khai Mun Lee, Teng Hwee Tan, Jen Hui Jeffrey Low, Soon Yau Joseph Ng, Arunachalam Ilancheran, Liang Shen, Johann Tang
PURPOSE: To report late rectal and bladder toxicity outcomes of a CT-based image-guided brachytherapy (IGBT) technique for treatment of cervical cancer. METHODS AND MATERIALS: Between 2008 and 2014, 95 women with International Federation of Gynecology and Obstetrics stage IB to IVA cervical carcinoma treated with definitive concurrent cisplatin-based chemotherapy and external beam radiation therapy 50.4 Gy in 28 fractions followed by planned prescription dose of 7 Gy × 4 fractions of high-dose-rate IGBT was retrospectively reviewed...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27790408/the-mri-linear-accelerator-consortium-evidence-based-clinical-introduction-of-an-innovation-in-radiation-oncology-connecting-researchers-methodology-data-collection-quality-assurance-and-technical-development
#8
Linda G W Kerkmeijer, Clifton D Fuller, Helena M Verkooijen, Marcel Verheij, Ananya Choudhury, Kevin J Harrington, Chris Schultz, Arjun Sahgal, Steven J Frank, Joel Goldwein, Kevin J Brown, Bruce D Minsky, Marco van Vulpen
An international research consortium has been formed to facilitate evidence-based introduction of MR-guided radiotherapy (MR-linac) and to address how the MR-linac could be used to achieve an optimized radiation treatment approach to improve patients' survival, local, and regional tumor control and quality of life. The present paper describes the organizational structure of the clinical part of the MR-linac consortium. Furthermore, it elucidates why collaboration on this large project is necessary, and how a central data registry program will be implemented...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27788947/learning-from-trials-on-radiation-dose-in-non-small-cell-lung-cancer
#9
REVIEW
Jeffrey Bradley, Chen Hu
In this issue of the International Journal of Radiation Oncology • Biology • Physics, Taylor et al present a meta-analysis of published data supporting 2 findings: (1) radiation dose escalation seems to benefit patients who receive radiation alone for non-small cell lung cancer; and (2) radiation dose escalation has a detrimental effect on overall survival in the setting of concurrent chemotherapy. The latter finding is supported by data but has perplexed the oncology community. Perhaps these findings are not perplexing at all...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27786406/childhood-hodgkin-international-prognostic-score-chips-predicts-event-free-survival-in-hodgkin-lymphoma-a-report-from-the-children-s-oncology-group
#10
Cindy L Schwartz, Lu Chen, Kathleen McCarten, Suzanne Wolden, Louis S Constine, Robert E Hutchison, Pedro A de Alarcon, Frank G Keller, Kara M Kelly, Tanya A Trippet, Stephan D Voss, Debra L Friedman
BACKGROUND: Early response to initial chemotherapy in Hodgkin lymphoma (HL) measured by computed tomography (CT) and/or positron emission tomography (PET) after two to three cycles of chemotherapy may inform therapeutic decisions. Risk stratification at diagnosis could, however, allow earlier and potentially more efficacious treatment modifications. PATIENTS AND METHODS: We developed a predictive model for event-free survival (EFS) in pediatric/adolescent HL using clinical data known at diagnosis from 1103 intermediate-risk HL patients treated on Children's Oncology Group protocol AHOD0031 with doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide (ABVE-PC) chemotherapy and radiation...
October 27, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27775259/major-clinical-research-advances-in-gynecologic-cancer-in-2015
#11
REVIEW
Dong Hoon Suh, Miseon Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27721877/radiation-pneumonitis-in-association-with-internal-mammary-node-irradiation-in-breast-cancer-patients-an-ancillary-result-from-the-krog-08-06-study
#12
Jinhyun Choi, Yong Bae Kim, Kyung Hwan Shin, Sung-Ja Ahn, Hyung-Sik Lee, Won Park, Su Ssan Kim, Jin Hee Kim, Kyu Chan Lee, Dong Won Kim, Hyun Suk Suh, Kyung Ran Park, Hyun Soo Shin, Chang-Ok Suh
PURPOSE: The aim of this study is to present the incidence of radiation pneumonitis (RP) reported within 6 months after treatment for breast cancer with or without internal mammary node irradiation (IMNI). METHODS: In the Korean Radiation Oncology Group (KROG) 08-06 phase III randomized trial, patients who were node-positive after surgery were randomly assigned to receive radiotherapy either with or without IMNI. A total of 747 patients were enrolled, and three-dimensional treatment planning with computed tomography simulation was performed for all patients...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27674985/practice-patterns-of-palliative-radiation-therapy-in-pediatric-oncology-patients-amongst-an-international-pediatric-research-consortium
#13
A D Rao, R P Ermoian, S R Alcorn, M L S Figueiredo, M J Chen, K Dieckmann, S MacDonald, M Ladra, D Kobyzeva, A Nechesnyuk, K Nilsson, B Winey, R C Villar, S A Terezakis
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674621/development-of-a-quality-and-safety-competency-curriculum-for-radiation-oncology-residency-an-international-delphi-study
#14
J Adleman, C Gillan, A L Caissie, C A Davis, B E Liszewski, A L McNiven, M E Giuliani
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27667293/-close-follow-up-of-oncologic-patients-with-imaging-advantage-or-disadvantage
#15
Dániel Deme, András Telekes
The International Commission on Radiological Protection estimates, that 100 mSv exposure of radiation increases cancer risk by 0.5%. The central hypothesis of the Linear No Threshold model is that low dose ionizing radiation can induce carcinogenesis through the so called "one hit action", that is one or more deoxyribonucleic acid strands can be broken by the hit of only one electron particule. Regardless of the radiation dose, radiation exposure increases cancer risk. In the United States of America, one-third of computed tomographic scans are carried with no clear clinical indication, i...
September 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27663761/contemporary-trends-in-radiation-oncology-resident-research
#16
Vivek Verma, Lindsay Burt, Phyllis A Gimotty, Eric Ojerholm
PURPOSE: To test the hypothesis that recent resident research productivity might be different than a decade ago, and to provide contemporary information about resident scholarly activity. METHODS AND MATERIALS: We compiled a list of radiation oncology residents from the 2 most recent graduating classes (June 2014 and 2015) using the Association of Residents in Radiation Oncology annual directories. We queried the PubMed database for each resident's first-authored publications from postgraduate years (PGY) 2 through 5, plus a 3-month period after residency completion...
August 11, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27663387/an-independently-validated-nomogram-for-individualized-estimation-of-survival-among-patients-with-newly-diagnosed-glioblastoma-nrg-oncology-rtog-0525-and-0825
#17
Haley Gittleman, Daniel Lim, Michael W Kattan, Arnab Chakravarti, Mark R Gilbert, Andrew B Lassman, Simon S Lo, Mitchell Machtay, Andrew E Sloan, Erik P Sulman, Devin Tian, Michael A Vogelbaum, Tony J C Wang, Marta Penas-Prado, Emad Youssef, Deborah T Blumenthal, Peixin Zhang, Minesh P Mehta, Jill S Barnholtz-Sloan
BACKGROUND: Glioblastoma (GBM) is the most common primary malignant brain tumor. Nomograms are often used for individualized estimation of prognosis. This study aimed to build and independently validate a nomogram to estimate individualized survival probabilities for patients with newly diagnosed GBM, using data from 2 independent NRG Oncology Radiation Therapy Oncology Group (RTOG) clinical trials. METHODS: This analysis included information on 799 (RTOG 0525) and 555 (RTOG 0825) eligible and randomized patients with newly diagnosed GBM and contained the following variables: age at diagnosis, race, gender, Karnofsky performance status (KPS), extent of resection, O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status, and survival (in months)...
September 23, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27659727/postmastectomy-radiotherapy-an-american-society-of-clinical-oncology-american-society-for-radiation-oncology-and-society-of-surgical-oncology-focused-guideline-update
#18
Abram Recht, Elizabeth A Comen, Richard E Fine, Gini F Fleming, Patricia H Hardenbergh, Alice Y Ho, Clifford A Hudis, E Shelley Hwang, Jeffrey J Kirshner, Monica Morrow, Kilian E Salerno, George W Sledge, Lawrence J Solin, Patricia A Spears, Timothy J Whelan, Mark R Somerfield, Stephen B Edge
: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastectomy radiotherapy (PMRT). METHODS: A recent systematic literature review by Cancer Care Ontario provided the primary evidentiary basis. The joint panel also reviewed targeted literature searches to identify new, potentially practice-changing data...
November 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27646947/postmastectomy-radiotherapy-an-american-society-of-clinical-oncology-american-society-for-radiation-oncology-and-society-of-surgical-oncology-focused-guideline-update
#19
Abram Recht, Elizabeth A Comen, Richard E Fine, Gini F Fleming, Patricia H Hardenbergh, Alice Y Ho, Clifford A Hudis, E Shelley Hwang, Jeffrey J Kirshner, Monica Morrow, Kilian E Salerno, George W Sledge, Lawrence J Solin, Patricia A Spears, Timothy J Whelan, Mark R Somerfield, Stephen B Edge
PURPOSE: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastectomy radiotherapy (PMRT). METHODS: A recent systematic literature review by Cancer Care Ontario provided the primary evidentiary basis. The joint panel also reviewed targeted literature searches to identify new, potentially practice-changing data...
September 19, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27646018/postmastectomy-radiotherapy-an-american-society-of-clinical-oncology-american-society-for-radiation-oncology-and-society-of-surgical-oncology-focused-guideline-update
#20
Abram Recht, Elizabeth A Comen, Richard E Fine, Gini F Fleming, Patricia H Hardenbergh, Alice Y Ho, Clifford A Hudis, E Shelley Hwang, Jeffrey J Kirshner, Monica Morrow, Kilian E Salerno, George W Sledge, Lawrence J Solin, Patricia A Spears, Timothy J Whelan, Mark R Somerfield, Stephen B Edge
PURPOSE: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastectomy radiotherapy (PMRT). METHODS: A recent systematic literature review by Cancer Care Ontario provided the primary evidentiary basis. The joint panel also reviewed targeted literature searches to identify new, potentially practice-changing data...
September 19, 2016: Annals of Surgical Oncology
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