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https://www.readbyqxmd.com/read/28722180/a-generic-tg-186-shielded-applicator-for-commissioning-model-based-dose-calculation-algorithms-for-high-dose-rate-192-ir-brachytherapy
#1
Yunzhi Ma, Javier Vijande, Facundo Ballester, Åsa Carlsson Tedgren, Domingo Granero, Annette Haworth, Firas Mourtada, Gabriel Paiva Fonseca, Kyveli Zourari, Panagiotis Papagiannis, Mark J Rivard, Frank André Siebert, Ron S Sloboda, Ryan Smith, Marc J P Chamberland, Rowan M Thomson, Frank Verhaegen, Luc Beaulieu
PURPOSE: A joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform model-based dose calculation algorithms (MBDCA) dose calculations and comparisons. Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No...
July 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28717703/global-access-to-radiotherapy-services-have-we-made-progress-during-the-past-decade
#2
Mei Ling Yap, Eduardo Zubizarreta, Freddie Bray, Jacques Ferlay, Michael Barton
PURPOSE: The global incidence of cancer is rising, particularly in low- and middle-income countries. Radiotherapy is an important cancer treatment in the curative and palliative setting. We aimed to estimate the global demand for and supply of radiotherapy megavoltage machines (MVMs) and assess the changes in supply and demand during the past decade. MATERIALS AND METHODS: Cancer incidences for 27 cancer types in 184 countries were extracted from the International Agency for Research on Cancer GLOBOCAN database...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28714454/a-back-projection-algorithm-in-the-presence-of-an-extra-attenuating-medium-towards-epid-dosimetry-for-the-mr-linac
#3
I Torres-Xirau, I Olaciregui-Ruiz, R A Rozendaal, P González, B J Mijnheer, J-J Sonke, U A van der Heide, A Mans
In external beam radiotherapy, electronic portal imaging devices (EPIDs) are frequently used for pre-treatment and for in vivo dose verification. Currently, various MR-guided radiotherapy systems are being developed and clinically implemented. Independent dosimetric verification is highly desirable. For this purpose we adapted our EPID-based dose verification system for use with the MR-Linac combination developed by Elekta in cooperation with UMC Utrecht and Philips. In this study we extended our back-projection method to cope with the presence of an extra attenuating medium between the patient and the EPID...
July 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28711183/fast-protocol-for-radiochromic-film-dosimetry-using-a-cloud-computing-web-application
#4
Juan-Francisco Calvo-Ortega, Miquel Pozo, Sandra Moragues, Joan Casals
PURPOSE: To investigate the feasibility of a fast protocol for radiochromic film dosimetry to verify intensity-modulated radiotherapy (IMRT) plans. METHOD AND MATERIALS: EBT3 film dosimetry was conducted in this study using the triple-channel method implemented in the cloud computing application (Radiochromic.com). We described a fast protocol for radiochromic film dosimetry to obtain measurement results within 1h. Ten IMRT plans were delivered to evaluate the feasibility of the fast protocol...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28708234/physicists-views-on-hadrontherapy-a-survey-of-members-of-the-italian-association-of-medical-physics-aifm
#5
Tommaso Giandini, Chiara Tenconi, Mauro Carrara, Mario Ciocca, Stefania Russo, Costanza M V Panaino, Federica Cattani, Delia Ciardo, Sara Morlino, Barbara Avuzzi, Nice Bedini, Sergio Villa, Giulia Marvaso, Paola Romanelli, Azusa Hasegawa, Barbara Vischioni, Francesca Valvo, Barbara A Jereczek-Fossa, Roberto Orecchia, Riccardo Valdagni, Emanuele Pignoli
BACKGROUND: This study was based on a survey to investigate perceptions of hadrontherapy of the members of the Italian Association of Medical Physics (AIFM). The survey was digitally submitted to the 991 members between the end of January and the beginning of April 2016. METHODS: A 19-item questionnaire was designed focusing on advantages and disadvantages of hadrontherapy, current status and possible future improvements, and need and opportunities for future investments in Italy and abroad...
July 8, 2017: Tumori
https://www.readbyqxmd.com/read/28702826/head-and-neck-diffuse-large-b-cell-lymphomas-hn-dlbcl-in-human-immunodeficiency-virus-hiv-positive-patients-long-term-results-in-the-highly-active-antiretroviral-therapy-haart-era
#6
Francesca De Felice, Andrea Di Mino, Lavinia Grapulin, Maria Lusia Mistrulli, Daniela Musio, Vincenzo Tombolini
To report long-term outcomes and toxicity rates after chemotherapy (CHT) followed by radiotherapy (RT) in the highly active antiretroviral therapy (HAART) era in human immunodeficiency virus (HIV) positive patients with head and neck diffuse large B cell lymphomas (HN-DLBCL). Clinical data concerning consecutive HIV patients treated for DLBCL located in head and neck region with CHT and RT were retrospectively reviewed. Systemic treatment consisted of combination CHT agents given with concomitant HAART and regimen was left to oncologists' discretion...
July 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28693792/cholangiocarcinoma
#7
REVIEW
Michela Squadroni, Luca Tondulli, Gemma Gatta, Stefania Mosconi, Giordano Beretta, Roberto Labianca
Biliary tract cancer accounts for <1% of all cancers and affects chiefly an elderly population, with predominance in men. We distinguish cholangiocarcinoma (intrahepatic, hilar and distal) and gallbladder cancer, with different pathogenesis and prognosis. The treatment is based on surgery (whenever possible), radiotherapy in selected cases, and chemotherapy. The standard cytotoxic treatment for advanced/metastatic disease is represented by the combination of gemcitabine and cisplatin, whereas fluoropyrimidines are generally administered in second line setting...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28688694/nutritional-changes-in-patients-with-locally-advanced-head-and-neck-cancer-during-treatment
#8
L Arribas, L Hurtós, M Taberna, I Peiró, E Vilajosana, A Lozano, S Vazquez, R Mesia, N Virgili
OBJECTIVE: The purpose of the study is to evaluate changes in body composition and nutritional status that occur throughout the oncological treatment in head and neck cancer patients. METHODS: A prospective cohort observational study in patients diagnosed with head and neck squamous cell carcinoma (HNSCC) that underwent treatment with induction chemotherapy (iCT) followed by chemoradiotherapy or bioradiotherapy were invited to participate. All patients had dietetic counseling from the diagnosis and a close monitoring throughout the treatment implementing nutritional support as needed...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28686531/microenvironment-and-dose-delivery-dependent-response-after-exposure-to-ionizing-radiation-in-human-colorectal-cancer-cell-lines
#9
Vaidotas Stankevicius, Gintautas Vasauskas, Ryte Rynkeviciene, Jonas Venius, Vita Pasukoniene, Eduardas Aleknaviciusa, Kestutis Suziedelisa
A significant body of knowledge about radiobiology is based on studies of single dose cellular irradiation, despite the fact that conventional clinical applications using dose fractionation. In addition, cellular radiation response strongly depends on cell-cell and cell-extracellular matrix (ECM) interactions, which are poorly established in cancer cells grown under standard 2D cell culture conditions. In this study, we investigated the response of human colorectal carcinoma (CRC) DLD1 and HT29 cell lines, bearing distinct p53 mutations, to a single 2 or 10 Gy dose or fractionated 5 × 2 Gy doses of radiation using global transcriptomics analysis...
July 7, 2017: Radiation Research
https://www.readbyqxmd.com/read/28663738/cerebral-microstructural-alterations-after-radiation-therapy-in-high-grade-glioma-a-diffusion-tensor-imaging-based-study
#10
Rebecca Kassubek, Martin Gorges, Mike-Andrew Westhoff, Albert C Ludolph, Jan Kassubek, Hans-Peter Müller
OBJECTIVE: To investigate radiation therapy-induced microstructural damage of white matter in patients with high-grade glioma by diffusion tensor imaging (DTI). METHODS: DTI was performed in 18 patients with high-grade glioma (WHO grades III and IV) and 13 healthy controls. DTI images were cross-sectionally aligned for the calculation of baseline fractional anisotropy (FA). Interhemispheric FA values in patients with high-grade glioma before or without brain radiation therapy were compared with the interhemispheric FA values in patients after radiation therapy and in healthy controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28662680/systematic-review-of-patient-reported-quality-of-life-following-stereotactic-ablative-radiotherapy-for-primary-and-metastatic-liver-cancer
#11
REVIEW
Adam Mutsaers, Jeffrey Greenspoon, Cindy Walker-Dilks, Anand Swaminath
BACKGROUND: Stereotactic ablative radiotherapy (SABR) is a safe and effective modality in patients with liver cancer who are ineligible for other local therapies. However SABR is not current standard of practice and requires further validation. Patient reported quality of life (QOL) is key to this validation, yet no systematic reviews to date have been performed to analyse QOL following liver SABR. QOL is a critical part of therapy evaluation, particularly in disease states with short life expectancy...
June 29, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28660822/comparison-of-prognostic-scoring-systems-in-follicular-thyroid-cancer
#12
K W Teo, N K Yuan, W B Tan, R Parameswaran
INTRODUCTION Many studies have addressed the accuracy of prognostic scoring systems in the treatment of differentiated thyroid cancers as a whole but few have addressed this issue in patients with follicular thyroid cancer (FTC) alone. The aim of this study was to establish the accuracy of the various scoring systems in determining the overall and disease free survival of FTC patients in Singapore. METHODS Retrospective review was undertaken of 82 patients with FTC treated at a single tertiary institution between January 2000 and December 2014...
July 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28626489/conference-report-on-the-indo-global-summit-on-head-and-neck-oncology-igshno-2017-bmcon-iv-24-26-february-2017-jaipur-india
#13
Tej Prakash Soni, Anil K Gupta, Lalit M Sharma, Pawan Singhal, Dinesh Yadav, Umesh Bansal
'The multidisciplinary approach: expanding treatment horizons for head and neck cancer' was the major theme of the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV). The meeting, held in Jaipur (Rajasthan, India) from 24 to 26 February 2017, assembled 600 participants from India and worldwide. It was organised by the Bhagwan Mahaveer Cancer Hospital and Research Centre (BMCHRC), Jaipur. BMCHRC Jaipur is one of the largest superspeciality oncology research and treatment centres in north India...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28623402/the-impact-of-breast-cancer-treatments-on-sleep-quality-1%C3%A2-year-after-cancer-diagnosis
#14
Filipa Fontes, Susana Pereira, Ana Rute Costa, Marta Gonçalves, Nuno Lunet
PURPOSE: The increasing number of women living longer with potential side effects of breast cancer treatment highlights the need of a comprehensive assessment of its burden. Therefore, we aimed to quantify the relation between different breast cancer treatments and sleep quality 1 year after diagnosis. METHODS: A cohort of 502 newly diagnosed breast cancer patients was prospectively followed. Sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI), at baseline and at the 1-year follow-up...
June 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28622338/multi-phase-simultaneous-segmentation-of-tumor-in-lung-4d-ct-data-with-context-information
#15
Zhengwen Shen, Huafeng Wang, Weiwen Xi, Xiaogang Deng, Jin Chen, Yu Zhang
Lung 4D computed tomography (4D-CT) plays an important role in high-precision radiotherapy because it characterizes respiratory motion, which is crucial for accurate target definition. However, the manual segmentation of a lung tumor is a heavy workload for doctors because of the large number of lung 4D-CT data slices. Meanwhile, tumor segmentation is still a notoriously challenging problem in computer-aided diagnosis. In this paper, we propose a new method based on an improved graph cut algorithm with context information constraint to find a convenient and robust approach of lung 4D-CT tumor segmentation...
2017: PloS One
https://www.readbyqxmd.com/read/28616720/quality-of-life-after-whole-brain-radiotherapy-compared-with-radiosurgery-of-the-tumor-bed-results-from-a-randomized-trial
#16
L Kepka, D Tyc-Szczepaniak, K Osowiecka, A Sprawka, B Trąbska-Kluch, B Czeremszynska
BACKGROUND: A recent randomized trial (NCT01535209) demonstrated no difference in neurocognitive function between stereotactic radiotherapy of the tumor bed (SRT-TB) and whole brain radiotherapy (WBRT) in patients with resected single brain metastasis. Patients treated with SRT-TB had lower overall survival compared with the WBRT arm. Here, we compared the health-related quality of life (HRQOL) in patients who received WBRT vs. SRT-TB. METHODS: A self-reported questionnaire was used to assess HRQOL (EORTC QLQ-C30 with the QLQ-BN20 module) before RT, 2 months after RT, and every 3 months thereafter...
June 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28587740/evaluation-of-traditional-and-novel-echocardiographic-methods-of-cardiac-diastolic-dysfunction-post-radiotherapy-in-breast-cancer
#17
Hari P Sritharan, Geoffrey P Delaney, Queenie Lo, Vikneswary Batumalai, Wei Xuan, Liza Thomas
BACKGROUND: To investigate alterations in left ventricular (LV) diastolic function using traditional and novel echocardiographic parameters, following radiation therapy (RT) in breast cancer patients in the acute setting. METHODS: 40 chemotherapy-naïve women with left-sided breast cancer undergoing RT were prospectively recruited. A comprehensive transthoracic echocardiogram (TTE) was performed at baseline, during RT and 6weeks post-RT. Traditional echocardiographic diastolic parameters and diastolic strain rate were measured and analysed...
May 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28583726/results-of-short-term-radiotherapy-followed-by-radical-surgery-for-rectal-cancer-a-long-term-unicenter-observational-study
#18
Yolanda Saralegui, José M Enríquez-Navascués, Juan Pablo Ciria, Mikel Osorio, Adelaida Lacasta, Garazi Elorza, Maddi Garmendia, Carlos Placer
INTRODUCTION: Short-term radiotherapy (STR) for rectal cancer (RC) has rarely been used in Spain. The aim of the present study is to describe oncological results after RTC and surgery for RC. METHODS: This is a retrospective analysis of a consecutive series of patients treated with STR and surgery for RC (1999-2012). Epidemiological data, staging, complications of STR, STR-surgery interval, surgical approach, rate of anastomotic/perineal wound dehiscence, and pathological data (regression degree and staging) were collected...
May 2017: Cirugía Española
https://www.readbyqxmd.com/read/28571842/-evaluation-of-multidisciplinary-team-meeting-the-example-of-gynecological-mammary-cancers-in-a-tertiary-referral-center-in-morocco
#19
Wahid Chaouki, Mohsine Mimouni, Saber Boutayeb, Hafid Hachi, Hassan Errihani, Noureddine Benjaafar
The multidisciplinary team meeting has become a standard medical practice in oncology. However, no evaluation of this activity was carried out in Morocco. The aim of this study was to evaluate the multidisciplinary team meeting of gynecological mammary cancers in a National Tertiary Referral Center. The study was carried out by retrospective analysis of 207 cases of patients randomly selected among the 1190 cases recruited during the year 2015. Completeness and quality criteria were evaluated. The global completeness rate of passage in multidisciplinary team meeting is 38%...
May 29, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28570730/efficacy-of-stereotactic-conformal-radiotherapy-vs-conventional-radiotherapy-on-benign-and-low-grade-brain-tumors-a-randomized-clinical-trial
#20
Rakesh Jalali, Tejpal Gupta, Jayant S Goda, Savita Goswami, Nalini Shah, Debnarayan Dutta, Uday Krishna, Jayita Deodhar, Padmavati Menon, Sadhna Kannan, Rajiv Sarin
Importance: Evidence for application of stereotactic and other conformal radiotherapy techniques in treating brain tumors is largely based on data derived from dosimetric, retrospective, or small prospective studies. Therefore, we conducted a randomized clinical trial of stereotactic conformal radiotherapy (SCRT) compared with conventional radiotherapy (ConvRT) evaluating clinically meaningful end points. Objective: To compare neurocognitive and endocrine functional outcomes and survival at 5 years in young patients with residual and/or progressive benign or low-grade brain tumors treated with SCRT and ConvRT techniques...
June 1, 2017: JAMA Oncology
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