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https://www.readbyqxmd.com/read/27903668/malignant-pleural-mesothelioma-an-update-on-investigation-diagnosis-and-treatment
#1
Anna C Bibby, Selina Tsim, Nikolaos Kanellakis, Hannah Ball, Denis C Talbot, Kevin G Blyth, Nick A Maskell, Ioannis Psallidas
Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to peak in the next few years.This article summarises the epidemiology and pathogenesis of malignant pleural mesothelioma, before describing some key factors in the patient experience and outlining common symptoms. Diagnostic approaches are reviewed, including imaging techniques and the role of various biomarkers...
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27873127/radiotherapy-induced-global-and-regional-differences-in-early-stage-left-sided-versus-right-sided-breast-cancer-patients-speckle-tracking-echocardiography-study
#2
Suvi Sirkku Tuohinen, Tanja Skyttä, Tuija Poutanen, Heini Huhtala, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen
Radiotherapy (RT) to the thoracic region increases late cardiovascular morbidity and mortality. The impact of breast cancer laterality on cardiac function is largely unknown. The aim of this prospective study was to compare RT-induced changes in left-sided and right-sided breast cancer patients using speckle tracking echocardiography (STE). Sixty eligible patients with left-sided breast cancer and 20 with right-sided breast cancer without chemotherapy were evaluated prospectively before and early after RT. A comprehensive echocardiographic examination included three dimensional measurements and STE of the left ventricle (LV)...
November 21, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27870878/3d-vmat-verification-based-on-monte-carlo-log-file-simulation-with-experimental-feedback-from-film-dosimetry
#3
A R Barbeiro, A Ureba, J A Baeza, R Linares, M Perucha, E Jiménez-Ortega, S Velázquez, J C Mateos, A Leal
A model based on a specific phantom, called QuAArC, has been designed for the evaluation of planning and verification systems of complex radiotherapy treatments, such as volumetric modulated arc therapy (VMAT). This model uses the high accuracy provided by the Monte Carlo (MC) simulation of log files and allows the experimental feedback from the high spatial resolution of films hosted in QuAArC. This cylindrical phantom was specifically designed to host films rolled at different radial distances able to take into account the entrance fluence and the 3D dose distribution...
2016: PloS One
https://www.readbyqxmd.com/read/27868328/long-term-outcome-of-the-adjustable-transobturator-male-system-atoms-results-of-a-european-multicentre-study
#4
Alexander Friedl, Sandra Mühlstädt, Roman Zachoval, Alessandro Giammò, Danijel Kivaranovic, Maximilian Rom, Paolo Fornara, Clemens Brössner
OBJECTIVE: To evaluate the long-term effectiveness and safety of the adjustable transobturator male system (ATOMS(®) , Agency for Medical Innovations A.M.I., Feldkirch, Austria) in a European-wide multicentre setting. PATIENTS AND METHODS: In all, 287 men with stress urinary incontinence (SUI) were treated with the ATOMS device between June 2009 and March 2016. Continence parameters (daily pad test/pad use), urodynamics (maximum urinary flow rate, voiding volume, residual urine), and pain/quality of life (QoL) ratings (visual analogue scale/Leeds Assessment of Neuropathic Symptoms and Signs, International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]/Patient Global Impression of Improvement [PGI-I]) were compared preoperatively and after intermediate (12 months) as well as after individual maximum follow-up...
November 21, 2016: BJU International
https://www.readbyqxmd.com/read/27853722/measurement-of-thyroid-dose-by-tld-arising-from-radiotherapy-of-breast-cancer-patients-from-supraclavicular-field
#5
B Farhood, M T Bahreyni Toossi, H Vosoughi, S Khademi, C Knaup
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading global cause of cancer death among women worldwide. Radiotherapy plays a significant role in treatment of breast cancer and reduces locoregional recurrence and eventually improves survival. The treatment fields applied for breast cancer treatment include: tangential, axillary, supraclavicular and internal mammary fields. OBJECTIVE: In the present study, due to the presence of sensitive organ such as thyroid inside the supraclavicular field, thyroid dose and its effective factors were investigated...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27805817/the-role-of-tgf-beta-and-ppar-alpha-signalling-pathways-in-radiation-response-of-locally-exposed-heart-integrated-global-transcriptomics-and-proteomics-analysis
#6
Vikram Subramanian, Ingar Seemann, Juliane Merl-Pham, Stefanie M Hauck, Fiona Anne Stewart, Michael J Atkinson, Soile Tapio, Omid Azimzadeh
Epidemiological data from patients undergoing radiotherapy for thoracic tumours clearly show the damaging effect of ionising radiation on cardiovascular system. The long-term impairment of heart function and structure after local high-dose irradiation is associated with systemic inflammatory response, contraction impairment, microvascular damage and cardiac fibrosis. The goal of the present study was to investigate molecular mechanisms involved in this process. C57BL/6J mice received a single X-ray dose of 16 Gy given locally to the heart at the age of 8 weeks...
November 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27798905/non-small-cell-lung-cancer-nsclc-in-octogenarians-in-clinical-practice
#7
Hirsh Koyi, Gunnar Hillerdal, Karl-Gustav Kölbeck, Daniel Brodin, Per Liv, Eva Brandén
BACKGROUND/AIM: Globally, an increasing proportion of cancer patients are aged >65 years and many are aged >70 years. Treatment of the elderly with lung cancer has, therefore, become an important issue. We performed a retrospective study of our patients to demonstrate how octogenarians with non-small cell lung cancer (NSCLC) are treated in real-life clinical practice. PATIENTS AND METHODS: This was a retrospective observational study of all elderly (≥80 years) patients with NSCLC referred to the Department of Respiratory Medicine and Allergy, Karolinska Hospital, Sweden, 2003-2010, and followed until June, 2016...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27796823/comprehensive-treatment-with-chinese-medicine-in-patients-with-advanced-non-small-cell-lung-cancer-a-multicenter-prospective-cohort-study
#8
Jie Liu, Hong-Sheng Lin, Wei Hou, Bao-Jin Hua, Pei-Tong Zhang, Jie Li, Shen-Yu Wang, Ying Xie, Yue Zhang, Guang-Ru Xie, Mei-Ying Zhang, Wen-Guang Shi, Nian-Bo Guan, Tian-Yu Guan, Cong-Huang Li, Li-Yuan Lu, Ying Zhang, Dao-Rui Li, Hao Liu
OBJECTIVE: To determine whether additional Chinese medicine (CM) could prolong survival and improve the quality of life (QOL) in patients with advanced non-small cell lung cancer (NSCLC) compared with Western medicine (WM) alone. METHODS: This was a multicenter, prospective cohort study. A total of 474 hospitalized patients with stage III-IV NSCLC were recruited and divided into 2 groups. Patients in the WM group received radiotherapy, chemotherapy, and optimal supportive therapy according to the National Comprehensive Cancer Network (NCCN) guidelines...
October 28, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27796820/whole-body-diffusion-weighted-magnetic-resonance-imaging-wb-dw-mri-vs-choline-positron-emission-tomography-computed-tomography-choline-pet-ct-for-selecting-treatments-in-recurrent-prostate-cancer
#9
A J Conde-Moreno, G Herrando-Parreño, R Muelas-Soria, J Ferrer-Rebolleda, R Broseta-Torres, M P Cozar-Santiago, F García-Piñón, C Ferrer-Albiach
OBJECTIVE: To determine the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) in detecting metastases by comparing the results with those from choline-positron emission tomography-computed tomography (choline-PET/CT) in patients with biochemical relapse after primary treatment, and no metastases in bone scintigraphy, CT and/or pelvic MRI, or metastatic/oligometastatic prostate cancer (PCa). Patients with this disease profile who could benefit from treatment with stereotactic body radiation therapy (SBRT) were selected and their responses to these techniques were rated...
October 31, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27733117/quality-of-life-of-early-stage-colorectal-cancer-patients-in-morocco
#10
Hind Mrabti, Mounia Amziren, Ibrahim ElGhissassi, Youssef Bensouda, Narjiss Berrada, Halima Abahssain, Saber Boutayeb, Samira El Fakir, Chakib Nejjari, Abdellatif Benider, Nawfel Mellas, Omar El Mesbahi, Maria Bennani, Rachid Bekkali, Ahmed Zidouh, Hassan Errihani
BACKGROUND: A multicentre cohort study was held in Morocco, designed to evaluate the quality of life of cancer patients. The aim of this paper is to report the assessment of the quality of life of early colorectal cancer patients, before and after cancer treatment, to identify other factors which are related to this quality of life. METHODS: We used the third version of the QLQ-C30 questionnaire of the European organization for Research and treatment of Cancer (EORTC) after a transcultural validation...
October 12, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27726226/symptoms-of-patients-with-head-and-neck-cancers-undergoing-radiotherapy
#11
K Kırca, S Kutlutürkan
Radiotherapy is a reliable and effective treatment method for the treatment of head and neck cancers. This study was conducted as a descriptive work with the purpose of determining the symptoms experienced by patients with head and neck cancer who are undergoing radiotherapy. The study was carried out on 47 patients receiving treatment in oncology clinics. Data were obtained at mid-radiotherapy (RT), at the end of radiotherapy and 1 month after the end of radiotherapy using the Memorial Symptom Assessment Scale (MSAS) and Personal Information Forms...
October 10, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27724890/quality-of-life-after-cancer-how-the-extent-of-impairment-is-influenced-by-patient-characteristics
#12
Elisabeth Peters, Laura Mendoza Schulz, Monika Reuss-Borst
BACKGROUND: Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quality of life and thus to identify those patients who need and can benefit most from specific intervention treatment. METHODS: 1879 cancer patients were given the EORTC QLQ C-30 questionnaire at the beginning and end of their inpatient rehabilitation...
October 10, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27698591/spiderplan-a-tool-to-support-decision-making-in-radiation-therapy-treatment-plan-assessment
#13
Tiago Ventura, Maria do Carmo Lopes, Brigida Costa Ferreira, Leila Khouri
AIM: In this work, a graphical method for radiotherapy treatment plan assessment and comparison, named SPIDERplan, is proposed. It aims to support plan approval allowing independent and consistent comparisons of different treatment techniques, algorithms or treatment planning systems. BACKGROUND: Optimized plans from modern radiotherapy are not easy to evaluate and compare because of their inherent multicriterial nature. The clinical decision on the best treatment plan is mostly based on subjective options...
November 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27687661/-super-resolution-reconstruction-for-4-dimensional-computed-tomography-of-the-lung-using-graph-cuts
#14
Jin Chen, Zheng-Wen Shen, Wei-Wen Xi, Yu Zhang
Four-dimensional computer tomography (4D-CT) has a great value in lung cancer radiotherapy for its capability in providing lung information with respiratory motion. We employed a global graph cuts super-resolution (SR) reconstruction method to reconstruct high-resolution lung 4D-CT images. First, the high-resolution images reconstruction energy function was built based on a Maximum a posteriori Markov Random Field (MAP-MRF) formulation. The energy function was then transformed to a graph formulation, which was solved using graph cut algorithm...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27686943/health-related-quality-of-life-in-patients-with-high-risk-low-grade-glioma-eortc-22033-26033-a-randomised-open-label-phase-3-intergroup-study
#15
Jaap C Reijneveld, Martin J B Taphoorn, Corneel Coens, Jacoline E C Bromberg, Warren P Mason, Khê Hoang-Xuan, Gail Ryan, Mohamed Ben Hassel, Roelien H Enting, Alba A Brandes, Antje Wick, Olivier Chinot, Michele Reni, Guy Kantor, Brian Thiessen, Martin Klein, Eugenie Verger, Christian Borchers, Peter Hau, Michael Back, Anja Smits, Vassilis Golfinopoulos, Thierry Gorlia, Andrew Bottomley, Roger Stupp, Brigitta G Baumert
BACKGROUND: Temozolomide chemotherapy versus radiotherapy in patients with a high-risk low-grade glioma has been shown to have no significant effect on progression-free survival. If these treatments have a different effect on health-related quality of life (HRQOL), it might affect the choice of therapy. We postulated that temozolomide compromises HRQOL and global cognitive functioning to a lesser extent than does radiotherapy. METHODS: We did a prospective, phase 3, randomised controlled trial at 78 medical centres and large hospitals in 19 countries...
September 26, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27670618/an-update-on-focal-therapy-for-prostate-cancer
#16
REVIEW
Marlon Perera, Nishanth Krishnananthan, Uri Lindner, Nathan Lawrentschuk
Globally, the increased uptake of serum PSA level screening led to an increase in the number of diagnoses of low-risk and intermediate-risk prostate cancer. Traditionally, these patients have been considered for either active surveillance programmes or radical whole-gland therapies, such as prostatectomy or radiotherapy. Focal therapy is an emerging treatment option that involves the focal ablation of prostate cancer with preservation of surrounding healthy tissue. This approach might result in reduced morbidity when compared with whole-gland therapies...
November 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27665737/expression-profiling-of-cutaneous-squamous-cell-carcinoma-with-perineural-invasion-implicates-the-p53-pathway-in-the-process
#17
Timothy A Warren, Natasa Broit, Jacinta L Simmons, Carly J Pierce, Sharad Chawla, Duncan L J Lambie, Gary Quagliotto, Ian S Brown, Peter G Parsons, Benedict J Panizza, Glen M Boyle
Squamous cell carcinoma (SCC) is the second most common cancer worldwide and accounts for approximately 30% of all keratinocyte cancers. The vast majority of cutaneous SCCs of the head and neck (cSCCHN) are readily curable with surgery and/or radiotherapy unless high-risk features are present. Perineural invasion (PNI) is recognized as one of these high-risk features. The molecular changes during clinical PNI in cSCCHN have not been previously investigated. In this study, we assessed the global gene expression differences between cSCCHN with or without incidental or clinical PNI...
September 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659692/a-new-questionnaire-qrfpc25-regarding-the-religiosity-and-spirituality-in-people-with-life-threatening-disease-reliability-and-validity-in-a-population-of-cancer-patients-undergoing-radiotherapy
#18
Vassilis Kouloulias, John Kokakis, Nikolaos Kelekis, John Kouvaris
The development of a questionnaire (QRFPC25) assessing the religiosity of cancer patients. The method used for the questionnaire comprises seven multi-item and three single-item scales formed from a 25-question module. The questionnaire was completed on-site and a week after antineoplastic therapy. The final sample included 156 patients. The main topics of the QRFPC25 are the following: worship, relationship with the divine, spiritual discussion, hope, participation in holly communion, faith, life after death, love, bioethics and global quality of life (QoL)...
September 22, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27642498/the-janus-faced-role-of-antioxidants-in-cancer-cachexia-new-insights-on-the-established-concepts
#19
REVIEW
Mohamad Assi, Amélie Rébillard
Chronic inflammation and excessive loss of skeletal muscle usually occur during cancer cachexia, leading to functional impairment and delaying the cure of cancer. The release of cytokines by tumor promotes the formation of reactive oxygen species (ROS), which in turn regulate catabolic pathways involved in muscle atrophy. ROS also exert a dual role within tumor itself, as they can either promote proliferation and vascularization or induce senescence and apoptosis. Accordingly, previous studies that used antioxidants to modulate these ROS-dependent mechanisms, in cancer and cancer cachexia, have obtained contradictory results, hence the need to gather the main findings of these studies and draw global conclusions in order to stimulate more oriented research in this field...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27631875/extreme-hypofractionation-for-early-prostate-cancer-biology-meets-technology
#20
Berardino De Bari, Stefano Arcangeli, Delia Ciardo, Rosario Mazzola, Filippo Alongi, Elvio G Russi, Riccardo Santoni, Stefano M Magrini, Barbara A Jereczek-Fossa
The aim of this review is to present the available radiobiological, technical and clinical data about extreme hypofractionation in primary prostate cancer radiotherapy. The interest in this technique is based on the favourable radiobiological characteristics of prostate cancer and supported by advantageous logistic aspects deriving from short overall treatment time. The clinical validity of short-term treatment schedule is proven by a body of non-randomised studies, using both isocentric (LINAC-based) or non-isocentric (CyberKnife(®)-based) stereotactic body irradiation techniques...
August 29, 2016: Cancer Treatment Reviews
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