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Global radiotherapy

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https://www.readbyqxmd.com/read/28334435/withdrawn-radioisotopes-for-metastatic-bone-pain
#1
REVIEW
Marta Roqué I Figuls, Maria José Martinez-Zapata, Martin Scott-Brown, Pablo Alonso-Coello
BACKGROUND: This is an update of the review published in Issue 4, 2003. Bone metastasis cause severe pain as well as pathological fractures, hypercalcaemia and spinal cord compression. Treatment strategies currently available to relieve pain from bone metastases include analgesia, radiotherapy, surgery, chemotherapy, hormone therapy, radioisotopes and bisphosphonates. OBJECTIVES: To determine efficacy and safety of radioisotopes in patients with bone metastases to improve metastatic pain, decrease number of complications due to bone metastases and improve patient survival...
March 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28332763/prevalence-of-obstructive-sleep-apnea-syndrome-following-oropharyngeal-cancer-treatment-a-prospective-cohort-study
#2
Anthony Loth, Justin Michel, Roch Giorgi, Laure Santini, Marc Rey, Jean-Marc Elbaum, Nicolas Roux, Antoine Giovanni, Patrick Dessi, Nicolas Fakhry
OBJECTIVES: To evaluate the prevalence of obstructive sleep apnea syndrome (OSAS) in a population of patients treated for an advanced cancer of the oropharynx (AJCC Stage III or IV), depending on treatment strategy and to evaluate its impact on quality of life. DESIGN: Prospective cohort study. SETTING: University Teaching Hospital of La Conception, Marseille, France. PARTICIPANTS: ifty-one disease free patients were included...
March 23, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28331888/new-concept-on-an-integrated-interior-magnetic-resonance-imaging-and-medical-linear-accelerator-system-for-radiation-therapy
#3
Xun Jia, Zhen Tian, Yan Xi, Steve B Jiang, Ge Wang
Image guidance plays a critical role in radiotherapy. Currently, cone-beam computed tomography (CBCT) is routinely used in clinics for this purpose. While this modality can provide an attenuation image for therapeutic planning, low soft-tissue contrast affects the delineation of anatomical and pathological features. Efforts have recently been devoted to several MRI linear accelerator (LINAC) projects that lead to the successful combination of a full diagnostic MRI scanner with a radiotherapy machine. We present a new concept for the development of the MRI-LINAC system...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28325246/challenges-and-prospects-for-providing-radiation-oncology-services-in-africa
#4
REVIEW
Onyinye Balogun, Danielle Rodin, Wilfred Ngwa, Surbhi Grover, John Longo
There are considerable challenges to meeting the demands of the impending cancer crisis in Africa. These include a rising incidence of cancer and cancer-related deaths, equipment and maintenance costs, and deficits in human resources and training. Addressing these issues would be crucial to tackling the increasing burden of cancer on the continent. Innovations in technology and collaborative efforts within the global oncology community have created promising solutions for establishing quality cancer care in Africa and eradicating the massive disparities that currently exist...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28325237/global-health-in-radiation-oncology-the-emergence-of-a-new-career-pathway
#5
REVIEW
Danielle Rodin, Mei Ling Yap, Surbhi Grover, John M Longo, Onyinye Balogun, Sandra Turner, Jesper G Eriksen, C Norman Coleman, Meredith Giuliani
The massive global shortfall in radiotherapy equipment and human resources in developing countries is an enormous challenge for international efforts in cancer control. This lack of access to treatment has been long-standing, but there is now a growing consensus about the urgent need to prioritize solutions to this problem and that a global strategy is required for them to be successful. An essential element of making radiotherapy universally accessible is a coordinated approach to clinical training and practice...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28318101/individual-volume-based-3d-gamma-indices-for-pretreatment-vmat-qa
#6
Jinling Yi, Ce Han, Xiaomin Zheng, Yongqiang Zhou, Zhenxiang Deng, Congying Xie, Xiance Jin, Fu Jin
Although gamma analysis is still a widely accepted quantitative tool to analyze and report patient-specific QA for intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT), the correlation between the 2D percentage gamma passing rate (%GP), and the clinical dosimetric difference for IMRT and VMAT has been questioned. The purpose of this study was to investigate the feasibility of individual volume-based 3D gamma indices for pretreatment VMAT QA. Percentage dosimetric errors (%DE) of dose-volume histogram metrics (includes target volumes and organ at risks) between the treatment planning system and QA-reconstructed dose distribution, %GPs for individual volume and global gamma indices, as well their correlations and sensitivities were investigated for one- and two-arc VMAT plans...
March 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28314270/global-microrna-expression-profiling-identifies-unique-microrna-pattern-of-radioresistant-glioblastoma-cells
#7
Jakub Ondracek, Pavel Fadrus, Jiri Sana, Andrej Besse, Tomas Loja, Marek Vecera, Lenka Radova, Martin Smrcka, Pavel Slampa, Ondrej Slaby
Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques and chemotherapy, the median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure is considered the presence of tumor cells resistant to conventional therapy, mainly radiotherapy. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and have been repeatedly proven to play important roles in pathogenesis and biological features of many cancers, including GBM and its radioresistant phenotype...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28299284/integral-dose-based-inverse-optimization-may-reduce-side-effects-in-radiotherapy-of-prostate-carcinoma
#8
Ivaylo B Mihaylov
PURPOSE: The purpose of this work is to apply a novel inverse optimization approach, based on utilization of quantitative imaging information in the optimization function, to prostate carcinoma. MATERIALS AND METHODS: This new inverse optimization algorithm relies upon quantitative information derived from computed tomography (CT) imaging studies. The Hounsfield numbers of the CT voxels are converted to physical density, which in turn is used to calculate voxel mass and the corresponding integral dose, by summation over the product of dose and mass in each dose voxel...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28294159/to-find-a-better-dosimetric-parameter-in-the-predicting-of-radiation-induced-lung-toxicity-individually-ventilation-perfusion-or-ct-based
#9
Lin-Lin Xiao, Guoren Yang, Jinhu Chen, Xiaohui Wang, Qingwei Wu, Zongwei Huo, Qingxi Yu, Jinming Yu, Shuanghu Yuan
This study aimed to find a better dosimetric parameter in predicting of radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) individually: ventilation(V), perfusion (Q) or computerized tomography (CT) based. V/Q single-photon emission computerized tomography (SPECT) was performed within 1 week prior to radiotherapy (RT). All V/Q imaging data was integrated into RT planning system, generating functional parameters based on V/Q SPECT. Fifty-seven NSCLC patients were enrolled in this prospective study...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28291401/pelvic-insufficiency-fracture-pif-incidence-in-patients-treated-with-intensity-modulated-radiation-therapy-imrt-for-gynaecological-or-anal-cancer-single-institution-experience-and-review-of-the-literature
#10
Louis Bazire, Haoping Xu, Jean-Philippe Foy, Malika Amessis, Caroline Malhaire, Kim Cao, Anne De La Rochefordiere, Youlia M Kirova
OBJECTIVE: To summarize the results of pelvic insufficiency fracture (PIF) incidence in patients with anal or gynaecological cancer treated by pelvic intensity-modulated radiation therapy (IMRT). METHODS: The clinical and morphological (CT and/or pelvic MRI) characteristics of patients treated by IMRT at our institution between 2007 and 2014 were analyzed. The global incidence of PIF after external beam radiotherapy and the impact of tumour site (gynaecological or anal cancer) were determined...
March 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28291159/67cu-radiolabeling-of-a-multimeric-rgd-peptide-for-%C3%AE-v%C3%AE-3-integrin-targeted-radionuclide-therapy-stability-therapeutic-efficacy-and-safety-studies-in-mice
#11
Zhao-Hui Jin, Takako Furukawa, Tomoyuki Ohya, Mélissa Degardin, Aya Sugyo, Atsushi B Tsuji, Yasuhisa Fujibayashi, Ming-Rong Zhang, Tatsuya Higashi, Didier Boturyn, Pascal Dumy, Tsuneo Saga
OBJECTIVE: Copper-67 (Cu) is one of the most promising radionuclides for internal radiation therapy. Globally, several projects have recently been initiated for developing innovative approaches for the large-scale production of Cu. Encouraged by these, we performed Cu-radiolabeling of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide conjugate, cyclam-RAFT-c(-RGDfK-)4, which selectively targets αVβ3 integrin (αVβ3), the transmembrane receptor involved in tumor invasion, angiogenesis, and metastasis...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28273341/still-equivalent-for-dose-calculation-in-the-monte-carlo-era-a-comparison-of-free-breathing-and-average-intensity-projection-ct-datasets-for-lung-sbrt-using-three-generations-of-dose-calculation-algorithms
#12
Kristina Zvolanek, Rongtao Ma, Christina Zhou, Xiaoying Liang, Shuo Wang, Vivek Verma, Xiaofeng Zhu, Qinghui Zhang, Joseph Driewer, Chi Lin, Weining Zhen, Andrew Wahl, Su-Min Zhou, Dandan Zheng
PURPOSE: Inhomogeneity dose modeling and respiratory motion description are two critical technical challenges for lung stereotactic body radiotherapy, an important treatment modality for small size primary and secondary lung tumors. Recent studies revealed lung density-dependent target dose differences between Monte Carlo (Type-C) algorithm and earlier algorithms. Therefore, this study aimed to investigate the equivalence of the two most popular CT datasets for treatment planning, free breathing (FB) and average intensity projection (AIP) CTs, using Type-C algorithms, and comparing with two older generation algorithms (Type-A and Type-B)...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28271639/first-australian-experience-of-treating-localised-prostate-cancer-patients-with-cyberknife-stereotactic-radiotherapy-early-psa-response-acute-toxicity-and-quality-of-life
#13
Ashutosh Dixit, Colin Tang, Sean Bydder, Mary-Anne Kedda, Eva Vosikova, Chrianna Bharat, Suki Gill
INTRODUCTION: This study is to evaluate biochemical response, acute toxicity and health-related quality-of-life (QOL) outcomes among prostate cancer patients following stereotactic body radiation therapy (SBRT) in the first Australian CyberKnife facility. METHODS: Forty-five consecutive patients with clinically localised prostate cancer were treated with SBRT using CyberKnife technology and enrolled in this study. Protocol treatment consisted of 36.25 Gy in five fractions...
March 8, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28262584/accelerated-partial-breast-irradiation-using-intensity-modulated-radiotherapy-versus-whole-breast-irradiation-health-related-quality-of-life-final-analysis-from-the-florence-phase-3-trial
#14
Icro Meattini, Calogero Saieva, Guido Miccinesi, Isacco Desideri, Giulio Francolini, Vieri Scotti, Livia Marrazzo, Stefania Pallotta, Fiammetta Meacci, Cristina Muntoni, Benedetta Bendinelli, Luis Jose Sanchez, Marco Bernini, Lorenzo Orzalesi, Jacopo Nori, Simonetta Bianchi, Lorenzo Livi
BACKGROUND: Accelerated partial breast irradiation (APBI) represents a valid option for selected early breast cancer (BC). We recently published the 5-year results of the APBI-IMRT-Florence phase 3 randomised trial (NCT02104895), showing a very low rate of disease failure, with acute and early-late toxicity in favour of APBI. We present the early and 2-year follow-up health-related quality of life (HRQoL) results. METHODS: Eligible patients were women aged more than 40 years with early BC suitable for breast-conserving surgery...
March 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28239989/advance-male-urethral-sling-medium-term-results-in-an-australian-cohort
#15
Alexander Papachristos, Sarah Mann, Kay Talbot, Daniel Moon
BACKGROUND: Since 2008, the AdVance male urethral sling has emerged as a minimally invasive option for stress urinary incontinence. We aimed to evaluate the success of the AdVance sling using validated continence outcome measures. METHODS: A total of 72 patients treated with the AdVance sling completed validated questionnaires reporting on quality of life and functional outcomes. Incontinence was assessed according to pad weight, pad usage per day (PPD), International Consultation on Incontinence Questionnaire scores and Patient Global Impression of Improvement scores...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28217733/impact-of-radiotherapy-on-psychological-financial-and-sexual-aspects-in-postmastectomy-carcinoma-breast-patients-a-prospective-study-and-management
#16
Neelam Sharma, Abhishek Purkayastha
OBJECTIVE: The aim of this study was to assess the impact of radiotherapy (RT) on psychological, financial, and sexual aspects in postmastectomy carcinoma breast patients affecting their quality of life (QOL) before, during, and after RT with a strong emphasis on their management and rehabilitation aspects. METHODS: A cross-sectional study carried out in a specialized institution, comprising sixty women. Two standardized questionnaires European Organization for Research and Treatment of Cancer (EORTC) 30-item Quality of Life Questionnaire and Quality of Life Questionnaire breast cancer-23 (QLQ-BR23) for health-related quality, translated and validated for the Hindi language were used...
January 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28196208/effect-of-radiotherapy-on-painful-bone-metastases-a-secondary-analysis-of-the-ncic-clinical-trials-group-symptom-control-trial-sc-23
#17
Rachel McDonald, Keyue Ding, Michael Brundage, Ralph M Meyer, Abdenour Nabid, Pierre Chabot, Genevieve Coulombe, Shahida Ahmed, Joda Kuk, A Rashid Dar, Aamer Mahmud, Alysa Fairchild, Carolyn F Wilson, Jackson S Y Wu, Kristopher Dennis, Carlo DeAngelis, Rebecca K S Wong, Liting Zhu, Stephanie Chan, Edward Chow
Importance: Many studies that found improved quality of life (QOL) after radiotherapy of bone metastases have small sample sizes and do not use specific questionnaires. How soon after radiotherapy one can expect an improvement in QOL is unknown. Objective: To investigate QOL at days 10 and 42 after radiotherapy with a bone metastases-specific QOL tool. Design, Setting, and Participants: In this secondary analysis of the NCIC Clinical Trials Group Symptom Control Trial SC...
February 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28152511/concurrent-chemoradiotherapy-degrades-the-quality-of-life-of-patients-with-stage-ii-nasopharyngeal-carcinoma-as-compared-to-radiotherapy
#18
Xin-Bin Pan, Shi-Ting Huang, Kai-Hua Chen, Yan-Ming Jiang, Jia-Lin Ma, Song Qu, Ling Li, Long Chen, Xiao-Dong Zhu
The purpose of this study was to compare the quality of life (QoL) of stage II nasopharyngeal carcinoma (NPC) patients treated with radiotherapy (RT) versus concurrent chemoradiotherapy (CCRT). In a cross-sectional study, these patients were treated with RT (n = 55) or CCRT (n = 51) between June 2008 and June 2013. For all subjects, disease-free survival was more than 3 years. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questions and the Head and Neck 35 (EORTC QLQ-H&N35) questions...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28138304/radiation-therapy-and-cancer-control-in-developing-countries-can-we-save-more-lives
#19
REVIEW
Rajamanickam Baskar, Koji Itahana
Globally, morbidity and mortality due to cancer are predicted to increase in both men and women in the coming decades. Furthermore, it is estimated that two thirds of these cancer-related deaths will occur in low-and middle-income countries (LMIC). In addition to morbidity and mortality, cancer also causes an enormous economic burden, especially in developing countries. There are several treatment and management options for cancer including chemotherapy, radiation therapy, surgery, and palliative care. Radiotherapy or radiation therapy (RT) can be an effective treatment, especially for localized or solid cancers; about half of cancer patients receive radiation as a curative or palliative treatment...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28134979/a-multiresolution-prostate-representation-for-automatic-segmentation-in-magnetic-resonance-images
#20
Charlens Alvarez, Fabio Martínez, Eduardo Romero
PURPOSE: Accurate prostate delineation is necessary in radiotherapy processes for concentrating the dose onto the prostate and reducing side effects in neighboring organs. Currently, manual delineation is performed over Magnetic Resonance Imaging (MRI) taking advantage of its high soft tissue contrast property. Nevertheless, since human intervention is a consuming task with high intra and inter-observer variability rates, (semi)-automatic organ delineation tools have emerged to cope with these challenges, reducing the time spent for these tasks...
January 30, 2017: Medical Physics
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