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https://www.readbyqxmd.com/read/28338341/natural-product-inhibitors-of-carbonic-anhydrase-i-and-ii-isoenzymes-osajin-and-pomiferin
#1
Esra Dilek, Hüseyin Serkan Erol, Ahmet Cakir, Murat Koc, Mesut Bünyami Halici
The aim of this study is to purify carbonic anhydrase I and II isoenzymes from human erythrocyte, isolate two natural products osajin (OSJ) and pomiferin (PMF) from Maclura pomifera fruits, and evaluate the in vitro effect of these natural metabolites on these isoenzymes. These natural products may be used as starting points for drug discovery (like drugs used in several therapeutic applications, including antiglaucoma activity). For the purification procedure, the Sepharose-4B-l-tyrosine-sulphonamide affinity chromatography was used...
March 24, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28336050/mortality-risk-disparities-in-children-receiving-chronic-renal-replacement-therapy-for-the-treatment-of-end-stage-renal-disease-across-europe-an-espn-era-edta-registry-analysis
#2
Nicholas C Chesnaye, Franz Schaefer, Marjolein Bonthuis, Rebecca Holman, Sergey Baiko, Esra Baskın, Anna Bjerre, Sylvie Cloarec, Elisabeth A M Cornelissen, Laura Espinosa, James Heaf, Rosário Stone, Diamant Shtiza, Ilona Zagozdzon, Jérôme Harambat, Kitty J Jager, Jaap W Groothoff, Karlijn J van Stralen
BACKGROUND: We explored the variation in country mortality rates in the paediatric population receiving renal replacement therapy across Europe, and estimated how much of this variation could be explained by patient-level and country-level factors. METHODS: In this registry analysis, we extracted patient data from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-EDTA) Registry for 32 European countries...
March 20, 2017: Lancet
https://www.readbyqxmd.com/read/28331768/external-jugular-vein-thrombosis-as-a-sign-of-metastatic-breast-cancer
#3
Metin Yalaza, Mehmet Tolga Kafadar, Esra Yurduseven Çıvgın, Arife Polat Düzgün
External jugular vein thrombosis is a rare vascular event which may lead fatal complication such as sepsis and pulmonary embolism. Its relation to the visceral solid tumor as an etiologic factor has been established well. Although external jugular vein thrombosis may be seen in malignancy, it is unusual to see as a sign of breast cancer. Most of the external jugular vein thrombosis occurs secondary to compression of the vein. Vascular thrombosis due to hypercoagulability is known as Trousseau syndrome. Herein, we present a case of metastatic breast cancer which presented with external jugular vein thrombosis; Trousseau syndrome...
January 2017: J Breast Health (2013)
https://www.readbyqxmd.com/read/28322505/evaluation-of-the-efficacy-and-color-stability-of-two-different-at-home-bleaching-systems-on-teeth-of-different-shades-a-randomized-controlled-clinical-trial
#4
Betül Aka, Esra Uzer Celik
OBJECTIVE: This randomized controlled clinical trial compared the bleaching efficacy of two different at-home bleaching systems on teeth of different shades and their color stability after a 6-month follow-up. MATERIALS AND METHODS: Ninety-two patients (777 teeth) were randomly divided into three groups: (a) negative control, (b) patients treated with a custom-made tray containing 10% carbamide peroxide (10% CP/PF) (Opalescence PF), and (c) patients treated with a pre-loaded tray containing 6% hydrogen peroxide (6% HP/Go) (Opalescence Go)...
March 21, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28321470/a-novel-selective-deep-eutectic-solvent-extraction-method-for-versatile-determination-of-copper-in-sediment-samples-by-icp-oes
#5
Esra Bağda, Huseyin Altundağ, Mustafa Tüzen, Mustafa Soylak
In the present study, a simple, mono step deep eutectic solvent (DES) extraction was developed for selective extraction of copper from sediment samples. The optimization of all experimental parameters, e.g. DES type, sample/DES ratio, contact time and temperature were performed with using BCR-280 R (lake sediment certified reference material). The limit of detection (LOD) and the limit of quantification (LOQ) were found as 1.2 and 3.97 µg L(-1), respectively. The RSD of the procedure was 7.5%. The proposed extraction method was applied to river and lake sediments sampled from Serpincik, Çeltek, Kızılırmak (Fadl and Tecer region of the river), Sivas-Turkey...
March 20, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28318371/p-selectin-endocan-and-some-adhesion-molecules-in-obese-children-and-adolescents-with-non-alcoholic-fatty-liver-disease
#6
Ala Ustyol, Esra Aycan Ustyol, Figen Gurdol, Funda Kokali, Seldag Bekpınar
There is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan and adhesion molecules such as P-selectin derived from the endothelium and platelets in obese children and adolescents with NAFLD. One hundred obese patients and 40 lean controls were enrolled. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver. Blood samples were assayed for endocan, P-selectin, platelet-derived growth factor (PDGF), intercellular cell adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28317703/detection-of-l-cysteine-in-wheat-flour-by-raman-microspectroscopy-combined-chemometrics-of-hca-and-pca
#7
Nur Cebi, Canan Ekinci Dogan, Ayşen Develioglu, Mediha Esra Altuntop Yayla, Osman Sagdic
l-Cysteine is deliberately added to various flour types since l-Cysteine has enabled favorable baking conditions such as low viscosity, increased elasticity and rise during baking. In Turkey, usage of l-Cysteine as a food additive isn't allowed in wheat flour according to the Turkish Food Codex Regulation on food additives. There is an urgent need for effective methods to detect l-Cysteine in wheat flour. In this study, for the first time, a new, rapid, effective, non-destructive and cost-effective method was developed for detection of l-Cysteine in wheat flour using Raman microscopy...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28315472/complex-postaxial-polydactyly-types-a-and-b-with-camptodactyly-hypoplastic-third-toe-zygodactyly-and-other-digit-anomalies-caused-by-a-novel-gli3-mutation
#8
Sara Mumtaz, Esra Yildiz, Karmoon Lal, Aslıhan Tolun, Sajid Malik
Polydactyly is a phenotypically and genetically highly heterogeneous limb malformation with preaxial and postaxial subtypes and subtypes A and B. Most polydactyly entities are associated with GLI3 mutation. We report on 10 affected individuals from a large Pakistani kindred initially evaluated as a possible new condition. The phenotype is postaxial polydactyly types A and B associated with zygodactyly, postaxial webbing of toes and additional features not previously reported for isolated polydactyly such as camptodactyly, hypoplasia of third toe, and wide space between hallux and second toe...
March 14, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28295203/pla2g6-mutations-associated-with-a-continuous-clinical-spectrum-from-neuroaxonal-dystrophy-to-hereditary-spastic-paraplegia
#9
Burcak Ozes, Nazan Karagoz, Rebecca Schüle, Adriana Rebelo, María-Jesús Sobrido, Florian Harmuth, Matthis Synofzik, Samuel Ignacio Pascual Pascual, Melek Colak, Beyza Ciftci-Kavaklioglu, Batuhan Kara, Andrés Ordóñez-Ugalde, Beatriz Quintáns, Michael A Gonzalez, Aysun Soysal, Stephan Zuchner, Esra Battaloglu
PLA2G6-associated neurodegeneration (PLAN) and hereditary spastic paraplegia (HSP) are two groups of heterogeneous neurodegenerative diseases. In this study, we report PLA2G6 gene mutations in three families from Turkey, Morocco, and Romania. Two affected Turkish siblings presenting HSP adds the disease to PLAN phenotypes. They were homozygous for the PLA2G6 missense c.2239C>T, p.Arg747Trp variant and the ages of onset were 9 and 21. Parkinsonism, dystonia or cognitive decline were not the clinical elements in these patients contrary to the cases that has been previously reported with the same variant, however, iron accumulation was evident in their cranial MRI...
March 13, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28291295/-association-between-parenting-styles-and-symptoms-of-attention-deficit-hyperactivity-disorder
#10
Esra Çöp, S Ebru Çengel Kültür, Gülser Şenses Dinç
OBJECTIVE: We aimed to study characteristics of child and mother reported parenting styles of children with Attention Deficit Hyperacitivity Disorder (ADHD) and association of parenting styles of mothers with demographic and clinical variables like ADHD symptoms, sex, age, ADHD subtype, and comorbidity. METHOD: 58 children with ADHD and 30 healthy children were included in this study. All children were assessed by The Schedule for Affective Disorders and Schizophrenia for School Aged Children- Present and Lifetime Version...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28285972/tp-e-interval-and-tp-e-qt-ratio-in-patients-with-human-immunodeficiency-virus
#11
Sefa Ünal, Çağrı Yayla, Burak Açar, Ahmet G Ertem, Mehmet K Akboğa, Serkan Gökaslan, Mehmet A Erdöl, Meliha Ç Sönmezer, Esra Kaya Kiliç, Çiğdem Ataman Hatipoğlu, Sinan Aydoğdu, Ahmet Temizhan
Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study...
March 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28285328/left-ventricular-mechanics-in-isolated-mild-mitral-stenosis-a-three-dimensional-speckle-tracking-study
#12
Esra Poyraz, Tuğba Kemaloğlu Öz, Gönül Zeren, Tolga Sinan Güvenç, Cevdet Dönmez, Fatma Can, Rengin Çetin Güvenç, Şennur Ünal Dayı
In a fraction of patients with mild mitral stenosis, left ventricular systolic function deteriorates despite the lack of hemodynamic load imposed by the dysfunctioning valve. Neither the predisposing factors nor the earlier changes in left ventricular contractility were understood adequately. In the present study we aimed to evaluate left ventricular mechanics using three-dimensional (3D) speckle tracking echocardiography. A total of 31 patients with mild rheumatic mitral stenosis and 27 healthy controls were enrolled to the study...
March 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28281957/effects-of-remineralization-agents-on-artificial-carious-lesions
#13
Selcuk Savas, Ebru Kucukyilmaz, Esra Uzer Celik
PURPOSE: The purpose of this study was to evaluate the remineralization potentials of different agents on demineralized enamel surfaces. METHODS: Four hundred and sixty extracted human molars with artificial carious lesions were divided into six groups: (1) control; (2) acidulated phosphate fluoride (APF); (3) Curodont Repair (CR); (4) silver diamine fluoride (SDF); (5) ammonium hexafluorosilicate (SiF); and (6) SiF plus cetylpiridinium chloride (SiF+CPC). They were subdivided according to immersion periods (seven out of 30 days)...
November 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28281727/atrial-electromechanical-delay-analyzed-by-tissue-doppler-echocardiography-is-prolonged-in-patients-with-generalized-anxiety-disorders
#14
Fatih Oksuz, Mikail Yarlioglues, Selcuk Ozturk, Fatma Duygu Kaya, Esra Oksuz, Sani Namık Murat, Osman Turak, Ibrahim Etem Celik, Alparslan Kilic, Alparslan Kurtul
BACKGROUND: It has been showed that psychological status is associated with the likelihood of atrial fibrillation (AF). Prolongation of the duration of atrial electromechanical delay (AEMD) is known to be a precursor for AF development. AIM: Therefore, we aimed to evaluate AEMD in patients with anxiety disorder. METHODS: In this prospective study, a total of 82 anxiety disorder and 80 healthy subjects were enrolled. Symptoms of anxiety were evaluated by using the hamilton anxiety rating scale (HAM-A)...
March 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28277389/organizational-silence-among-nurses-the-impact-on-organizational-cynicism-and-intention-to-leave-work
#15
Esra Çaylak, Serap Altuntaş
BACKGROUND: In recent years, organizational silence and organizational cynicism, factors that have been shown to inhibit the improvement of organizations, have been highlighted in the health sector. Nearly every aspect of these two issues has been studied. PURPOSE: This research was conducted to identify the relationship between the organizational silence, organizational cynicism, and intention to leave work of nurses. METHODS: This descriptive and correlational study was carried out in August and September 2013 with 323 nurses at a university hospital in Ankara...
April 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28276708/the-effect-of-carnosine-on-methylglyoxal-induced-oxidative-stress-in-rats
#16
Zülbiye Yılmaz, Esra Betül Kalaz, A Fatih Aydın, Merva Soluk-Tekkeşin, Semra Doğru-Abbasoğlu, Müjdat Uysal, Necla Koçak-Toker
Methylglyoxal (MG) is generated from glycolytic metabolites, lipid peroxidation, glucose autooxidation and protein glycation. It is a prooxidant inducing oxidative stress and formation of advanced glycation end products (AGE). Effect of carnosine (CAR) as an antioxidant on toxicity due to MG has generated interest. In this study, rats were given incrementally increased doses (100-300 mg/kg) of MG in drinking water for ten weeks. CAR (250 mg/kg i.p.) was administered with MG. Plasma thiobarbituric reactive substances (TBARS), protein carbonyl (PC), advanced oxidation protein products (AOPP) and AGE levels were elevated by MG, and CAR decreased PC, AOPP and AGE levels...
March 6, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28276148/direct-aspiration-vs-follicular-flushing-in-poor-responders-undergoing-icsi-a-randomised-controlled-trial
#17
Bulent Haydardedeoglu, Filiz Gjemalaj, Pinar Caglar Aytac, Esra Bulgan Kilicdag
OBJECTIVE: To compare three times follicle flushing with direct follicular aspiration in poor responders. Our hypothesis was that three times follicle flushing in poor responders result in similar oocyte yield compared to direct aspiration in poor responders. DESIGN: A randomised controlled trial performed between January 2015 and June 2015. SETTING: University hospital. POPULATION OR SAMPLE: Eighty eligible poor responders, who were defined as having five or fewer follicles ≥ 13 mm in average diameter with at least two follicles having maximum diameters >17 mm on the day of hCG...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28274232/perilipin-polymorphisms-are-risk-factors-for-the-development-of-obesity-in-adolescents-a-case-control-study
#18
Yavuz Tokgöz, Ishak Abdurrahman Işık, Soheil Akbari, Tuncay Kume, Oya Sayın, Esra Erdal, Nur Arslan
BACKGROUND: The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines. METHODS: A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR...
March 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28272672/primary-clear-cell-renal-cell-carcinoma-with-marked-intraluminal-mucin-secretion
#19
Oğuzhan Okcu, Kemal Behzatoğlu, Yasemin Çakir, Esra Paşaoğlu, Uğur Yücetaş
Clear cell renal cell carcinoma with mucin secretion is an unexpected situation. Primary renal adenocarcinoma and various metastatic carcinomas should be considered in the differential diagnosis. Prognostic significance is not yet fully known due to the limited number of reported cases, and these lesions have been grouped under unclassified renal cell carcinoma. In our study, clear cell renal cell carcinoma with significant luminal mucin secretion is discussed with its histological, histochemical and immunohistochemical features...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272666/cloacogenic-adenocarcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#20
Merih Tepeoğlu, Halit Üner, A Nihan Haberal, Özlem Özen, Esra Kuşçu
Primary adenocarcinoma of the vulva, unrelated to the native glands of perineum is an extremely rare neoplasm. Despite awareness of this lesion for over 40 years, the origin is not beyond speculation. The most reasonable hypothesis is based on the remnants of cloacal differentiation during early days of life. Here we report the case of a 60-year-old patient with a vulvar mass, who underwent partial vulvectomy and bilateral regional lymph node dissection. The tumor was composed of papillary and complex glandular structures and exhibited diffuse positivity for cytokeratin 20 and polyclonal CEA, CDX2, and focal positivity with cytokeratin 7...
February 4, 2017: Türk Patoloji Dergisi
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