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https://www.readbyqxmd.com/read/28207250/dna-product-formation-in-female-sprague-dawley-rats-following-polyhalogenated-aromatic-hydrocarbon-phah-exposure
#1
Lina Gao, Esra Mutlu, Leonard B Collins, Nigel J Walker, Hadley J Hartwell, James R Olson, Wei Sun, Avram Gold, Louise M Ball, James A Swenberg
DNA oxidation damage has been regarded as one of the possible mechanisms for the hepatic carcinogenesis of dioxin-like compounds (DLCs). In this study, we evaluated the toxic equivalency factor (TEF) from the standpoint of induced DNA oxidation products and their relationship to toxicity and carcinogenicity. Nine DNA oxidation products were analyzed in the liver of female Sprague-Dawley rats exposed to 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) alone or the tertiary mixture of TCDD, 3,3',4,4',5-pentachlorobiphenyl (PCB 126), and 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) by gavage for 14, 31, and 53 weeks (5 days/week) by LC-MS/MS: 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo); 1,N(6)-etheno-2'-deoxyadenosine (1,N(6)-εdAdo); N(2),3-ethenoguanine (N(2),3-εG); 7-(2-oxoethly)guanine (7-OEG); 1,N(2)-etheno-2'-deoxyguanosine (1,N(2)-εdGuo); malondialdehyde (M1dGuo); acrolein (AcrdGuo); crotonaldehyde (CrdGuo); and 4-hydroxynonenal (HNEdGuo) derived 2'-deoxyguanosine adducts...
February 16, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28202779/fasting-mimicking-diet-and-markers-risk-factors-for-aging-diabetes-cancer-and-cardiovascular-disease
#2
Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D Longo
Calorie restriction or changes in dietary composition can enhance healthy aging, but the inability of most subjects to adhere to chronic and extreme diets, as well as potentially adverse effects, limits their application. We randomized 100 generally healthy participants from the United States into two study arms and tested the effects of a fasting-mimicking diet (FMD)-low in calories, sugars, and protein but high in unsaturated fats-on markers/risk factors associated with aging and age-related diseases. We compared subjects who followed 3 months of an unrestricted diet to subjects who consumed the FMD for 5 consecutive days per month for 3 months...
February 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28198784/choroidal-thickness-in-patients-with-stargardt-disease
#3
Esra Vural, Ugur Acar, Mehmet K Sevinc, Mesut Erdurmus, Bekir Kucuk, Seckin Aykas, Gungor Sobaci
PURPOSE: To investigate the relationship between choroidal thicknesses (CT), central foveal thicknesses, multifocal electroretinography (mf-ERG) responses, and best-corrected visual acuity levels in patients with Stargardt disease (STGD). METHODS: A total of 30 eyes of 30 patients with STGD, and 30 age- and sex-matched healthy controls were included in the study. All participants underwent detailed ophthalmic examination including best-corrected visual acuity and spectral domain optical coherence tomography measurements, and also patients with STGD were performed mf-ERG...
February 14, 2017: Retina
https://www.readbyqxmd.com/read/28194364/comparison-of-two-different-methods-of-detecting-residual-caries
#4
Uzay Koç Vural, Zeynep Bilge Kütük, Esra Ergin, Filiz Yalçın Çakır, Sevil Gürgan
OBJECTIVES: The aim of this study was to investigate the ability of the fluorescence-aided caries excavation (FACE) device to detect residual caries by comparing conventional methods in vivo. MATERIALS AND METHODS: A total of 301 females and 202 males with carious teeth participated in this study. The cavity preparations were done by grade 4 (Group 1, 154 teeth), grade 5 (Group 2, 176 teeth), and postgraduate (Group 3, 173 teeth) students. After caries excavation using a handpiece and hand instruments, the presence of residual caries was evaluated by 2 investigators who were previously calibrated for visual-tactile assessment with and without magnifying glasses and trained in the use of a FACE device...
February 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28188350/amperometric-l-lysine-enzyme-electrodes-based-on-carbon-nanotube-redox-polymer-and-graphene-carbon-nanotube-redox-polymer-composites
#5
Ceren Kaçar, Pınar Esra Erden, Esma Kılıç
Highly sensitive L-lysine enzyme electrodes were constructed by using poly(vinylferrocene)-multiwalled carbon nanotubes-gelatine (PVF/MWCNTs-GEL) and poly(vinylferrocene)-multiwalled carbon nanotubes-gelatine-graphene (PVF/MWCNTs-GEL/GR) composites as sensing interfaces and their performances were evaluated. Lysine oxidase (LO) was immobilized onto the composite modified glassy carbon electrodes (GCE) by crosslinking using glutaraldehyde and bovine serum albumin. Effects of pH value, enzyme loading, applied potential, electrode composition, and interfering substances on the amperometric response of the enzyme electrodes were discussed...
February 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28185932/isolation-and-identification-of-chitin-from-heavy-mineralized-skeleton-of-suberea-clavata-verongida-demospongiae-porifera-marine-demosponge
#6
Hermann Ehrlich, Vasilii V Bazhenov, Cecile Debitus, Nicole de Voogd, Roberta Galli, Mikhail Tsurkan, Marcin Wysokowski, Heike Meissner, Esra Bulut, Murat Kaya, Teofil Jesionowski
Since the discovery of chitin in skeletal structures of sponges (Porifera) in 2007, studies on search of novel species which possess this structural aminopolysaccharide continue up today. The most potential source of chitin is suggested to be localized in the four families of sponges related to the order Verongida (Demospongiae) which nevertheless require further clarification. Here, we report for the first time the isolation and identification of α-chitin from the Suberea clavata demosponge (Aplysinidae: Verongida)...
February 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28183686/non-leukemic-granulocytic-sarcoma-presenting-with-multiple-lymphadenopathy
#7
Ayfer Gedük, Esra T Demirsoy, Süheyla U Bozkurt, Zafer Gülbaş, Serkan İşgören
No abstract text is available yet for this article.
February 9, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28174431/the-effect-of-walking-sticks-on-balance-in-geriatric-subjects
#8
Esra Dogru, Harun Kizilci, Nilay Comuk Balci, Nilufer Cetisli Korkmaz, Ozden Canbay, Nihan Katayifci
[Purpose] Guidelines and clarity regarding the information for deciding the need for walking sticks and the suitability of these sticks is insufficient. This study aimed to evaluate the suitability of walking stick and its effects on the balance in the elderly. [Subjects and Methods] A total of 39 elderly subjects aged between 65-95 years (mean age, 76.15 ± 8.35 years) and living in the Residential Aged Care and Rehabilitation Center were included. Sociodemographic data of the individuals, the material of the walking stick, who made the decision of usage and length of walking sticks were questioned...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28172794/factors-impacting-complication-rates-for-catheter-ablation-of-atrial-fibrillation-from-2003-to-2015
#9
Eunice Yang, Esra Gucuk Ipek, Muhammad Balouch, Yuliya Mints, Jonathan Chrispin, Joseph E Marine, Ronald D Berger, Hiroshi Ashikaga, Jack Rickard, Hugh Calkins, Saman Nazarian, David D Spragg
No abstract text is available yet for this article.
February 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28169460/alterations-of-the-hematologic-cells-in-synthetic-cannabinoid-users
#10
Derya Guzel, Ahmet Bulent Yazici, Esra Yazici, Atila Erol
BACKGROUND: Functions, morphology, distributions, and index of the circulating cells are the most useful parameters that indicate various inflammatory and toxic conditions. The aim of this study was to investigate the clinical significance of these parameters in patients diagnosed with (synthetic) cannabis use disorder. METHODS: This study included a total of 40 patients in the study group (SG) with synthetic cannabis use; and 40 healthy individuals as the control group (CG)...
February 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28162963/assessment-of-the-atrial-electromechanical-properties-of-patients-with-human-immunodeficiency-virus
#11
Ahmet G Ertem, Çağrı Yayla, Burak Açar, Sefa Ünal, Mehmet A Erdol, Meliha Ç Sonmezer, Esra Kaya Kiliç, Çiğdem Ataman Hatipoglu, Serkan Gokaslan, Habibe Kafes, Mehmet K Akboga, Pelin Aladag, Koray Demirtas, Sinan Aydogdu
The relationship between atrial fibrillation and human immunodeficiency virus (HIV) infection was evaluated. Electro-echocardiographic methods can be used to predict the development of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electromechanical delay (AEMD) parameters of HIV (+) patients. Forty-two HIV (+) patients and 40 HIV (-) healthy volunteers were prospectively enrolled in this study. The electromechanical properties of the subjects' atria were evaluated with tissue Doppler imaging...
February 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28154868/impact-of-liposomal-encapsulation-on-degradation-of-anthocyanins-of-black-carrot-extract-by-adding-ascorbic-acid
#12
Burcu Guldiken, Monika Gibis, Dilek Boyacioglu, Esra Capanoglu, Jochen Weiss
Black carrot anthocyanins are known to be relatively stable because they contain acylated anthocyanins. The degradation of vitamin C (l-ascorbic acid) on anthocyanins is a known fact in beverage systems. In this study, the effects of various liposomal systems, including black carrot extract (0.1%, 0.2%, 0.4% w/w) and lecithin (1%, 2%, 4% w/w), on the color and degradation of anthocyanin in different ascorbic acid (0.01%, 0.025%, 0.05%, 0.1% w/w) concentrations were examined via UV/VIS spectroscopy and visual control of the color...
February 3, 2017: Food & Function
https://www.readbyqxmd.com/read/28154145/estimating-the-population-level-impact-of-vaccines-using-synthetic-controls
#13
Christian A W Bruhn, Stephen Hetterich, Cynthia Schuck-Paim, Esra Kürüm, Robert J Taylor, Roger Lustig, Eugene D Shapiro, Joshua L Warren, Lone Simonsen, Daniel M Weinberger
When a new vaccine is introduced, it is critical to monitor trends in disease rates to ensure that the vaccine is effective and to quantify its impact. However, estimates from observational studies can be confounded by unrelated changes in healthcare utilization, changes in the underlying health of the population, or changes in reporting. Other diseases are often used to detect and adjust for these changes, but choosing an appropriate control disease a priori is a major challenge. The "synthetic controls" (causal impact) method, which was originally developed for website analytics and social sciences, provides an appealing solution...
February 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28153595/phenolic-compounds-the-inhibition-effect-on-polyol-pathway-enzymes
#14
Hatice Esra Aslan, Şükrü Beydemir
The polyol pathway called as sorbitol way is a small part of glycose metabolism. The pathway is regarded as an important element in the pathogenesis of various diabetic complications in individuals with diabetes mellitus. The pathway plays a crucial role in hyperglycemia. The polyol pathway contains two enzymes as aldose reductase (AR) and sorbitol dehydrogenase (SDH). In the present study, AR and SDH were purified from sheep liver by using simple chromatographic methods. AR was purified with a yield of 2.11% and approximately 162 fold and SDH was purified with a yield of 0...
January 30, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28152240/spatiotemporal-alignment-of-in-utero-bold-mri-series
#15
Esra Abaci Turk, Jie Luo, Borjan Gagoski, Javier Pascau, Carolina Bibbo, Julian N Robinson, P Ellen Grant, Elfar Adalsteinsson, Polina Golland, Norberto Malpica
PURPOSE: To present a method for spatiotemporal alignment of in-utero magnetic resonance imaging (MRI) time series acquired during maternal hyperoxia for enabling improved quantitative tracking of blood oxygen level-dependent (BOLD) signal changes that characterize oxygen transport through the placenta to fetal organs. MATERIALS AND METHODS: The proposed pipeline for spatiotemporal alignment of images acquired with a single-shot gradient echo echo-planar imaging includes 1) signal nonuniformity correction, 2) intravolume motion correction based on nonrigid registration, 3) correction of motion and nonrigid deformations across volumes, and 4) detection of the outlier volumes to be discarded from subsequent analysis...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28145780/cilioretinal-artery-vasculogenesis-might-be-promoted-by-plasminogen-activator-inhibitor-1-5g-allele
#16
Sarenur Yilmaz, Aylin Ardagil, Ibrahim Akalin, Meltem Guzin Altinel, Yasar Dag, Esra Kurum, Efe Koyun, Sevil Ari Yaylali, Huseyin Bayramlar
BACKGROUND: Cilioretinal arteries (CAs) represent enlargements of microscopic and early established collaterals formed via vasculogenesis between choroidal and retinal circulations. We aimed to investigate whether genetic tendency to thrombosis due to well-known gene polymorphisms may induce CA vasculogenesis in embryonic life. METHODS: We assessed plasminogen activator inhibitor-1 (PAI-1) 4G/5G, methylenetetrahydrofolatereductase (MTHFR), FACTOR V LEIDEN and PROTHROMBIN gene polymorphisms on 130 patients [82/48 females/males; Median age: 57 (18-84) with visible CAs and 100 (64/36: female/male; Median age: 55 (19-90)] without visible CAs...
February 1, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28139054/ustekinumab-for-the-treatment-of-acrodermatitis-continua-of-hallopeau-refractory-to-anti-tnf-agents
#17
Esra Adışen, İlkay Özer, Berkay Temel, Mehmet Ali Gürer
Acrodermatitis continua of Hallopeau (ACH) is a variant of pustular psoriasis that is often very difficult to treat. Almost all anti-psoriatic agents have been used in the treatment of ACH. Ustekinumab, a fully human monoclonal antibody of the IgG1 class, is directed to the shared p40 subunit of cytokines IL-12 and IL-23. Herein, we present our experience of ustekinumab use in a 50-year-old man who was resistant to anti-tumor necrosis factor-α agents. Though initial therapy with ustekinumab achieved a sustained response in our patient, after a seven months of interruption, retreatment resulted in a slower and poorer response than the initial regimen...
January 30, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28138865/effect-of-sensory-training-of-the-posterior-thigh-on-trunk-control-and-upper-extremity-functions-in-stroke-patients
#18
Esra Dogru Huzmeli, Sibel Aksu Yildirim, Muhammed Kilinc
Some studies show that sensorial rehabilitation is effective on functionality. The aim of this study is to investigate the effect of sensory training of the posterior thigh on the functionality of upper extremity and trunk control in stroke patients. Thirteen subjects (53.23 ± 6.82 years) were included in the intervention group and 13 subjects (58.69 ± 5.94 years) in the control group. The control and intervention groups were treated for ten sessions. The control group was treated only with neurodevelopmental treatment, and the intervention group was treated with sensorial training on the posterior thigh in addition to the neurodevelopmental treatment...
January 30, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28130294/transcellular-pathways-in-lymphatic-endothelial-cells-regulate-changes-in-solute-transport-by-fluid-stress
#19
Valentina Triacca, Esra Guc, Witold W Kilarski, Marco Pisano, Melody A Swartz
RATIONALE: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across lymphatic endothelial cells (LECs) is commonly considered to occur paracellularly, or between cell-cell junctions, and driven by local pressure and concentration gradients. However, emerging evidence suggests that LECs also play active roles in regulating interstitial solute balance and can scavenge and store antigens, raising the possibility that vesicular or transcellular pathways may be important in lymphatic solute transport...
January 27, 2017: Circulation Research
https://www.readbyqxmd.com/read/28124966/-a-case-of-bronchiolitis-obliterans-secondary-to-human-metapneumovirus-bronchiolitis
#20
Osman Yeşilbaş, Esra Şevketoğlu, Hasan Serdar Kıhtır, Mey Talip Petmezci, Elif Bato, Seda Balkaya, Nevin Hatipoğlu, Mert Ahmet Kuşkucu, Figen Palabıyık, Erkan Çakır
Human metapneumovirus (hMPV), formerly classified in Paramyxoviridae family is now moved into Pneumoviridae, which was described as a novel family. It causes upper and lower respiratory tract infections (LRTIs) usually in children younger than five years old. The recent epidemiological studies indicated that hMPV is the second most frequently detected virus in LRTIs of young children, following the respiratory syncytial virus (RSV). Bronchiolitis obliterans (BO) is a chronic obstructive lung disease characterized by fibrosis of the distal respiratory airways...
October 2016: Mikrobiyoloji Bülteni
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