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Concussion and nitrition

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https://www.readbyqxmd.com/read/27091089/electrophysiological-and-pathological-characterization-of-the-period-of-heightened-vulnerability-to-repetitive-injury-in-an-in-vitro-stretch-model
#1
Gwen B Effgen, Barclay Morrison
Clinical studies suggest that repeat exposures to mild traumatic brain injury (mTBI) or concussion, such as sports-related mTBI, result in verbal, memory, and motor deficits that can progressively worsen and take longer for recovery with each additional concussion. Pre-clinical studies suggest that mild mechanical injury of the brain can initiate a period of heightened vulnerability during which the brain is more susceptible to a subsequent mild injury. It is unknown how long this period of heightened vulnerability lasts and, as a result, appropriate return-to-play guidelines for athletes who have sustained sports-related mTBI could be better clarified...
February 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/17806141/temporal-window-of-metabolic-brain-vulnerability-to-concussions-oxidative-and-nitrosative-stresses-part-ii
#2
Barbara Tavazzi, Roberto Vagnozzi, Stefano Signoretti, Angela M Amorini, Antonio Belli, Marco Cimatti, Roberto Delfini, Valentina Di Pietro, Antonino Finocchiaro, Giuseppe Lazzarino
OBJECTIVE: In the present study, we investigated the occurrence of oxidative and nitrosative stresses in rats undergoing repeat mild traumatic brain injury (mTBI) delivered with increasing time intervals. METHODS: Rats were subjected to two diffuse mTBIs (450 g/1 m height), with the second mTBI delivered after 1 (n = 6), 2 (n = 6), 3 (n = 6), 4 (n = 6), or 5 days (n = 6). The rats were sacrificed 48 hours after the last mTBI. Sham-operated animals were used as controls (n = 6)...
August 2007: Neurosurgery
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