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Concussion and nitrition

Gwen B Effgen, Barclay Morrison Iii
Clinical studies suggest that repeat exposure to mild traumatic brain injury (mTBI) or concussion, such as sports-related mTBIs, result in verbal, memory and motor deficits that progressively worsen over time and take longer for recovery. Preclinical studies suggest mild mechanical injury of the brain can initiate a period of heightened vulnerability during which the brain is more susceptible to a subsequent mild injury. It is unknown how long this period of heightened vulnerability lasts and, as a result, appropriate return-to-play guidelines for athletes who have suffered sports-related mTBI could be better clarified...
April 18, 2016: Journal of Neurotrauma
Barbara Tavazzi, Roberto Vagnozzi, Stefano Signoretti, Angela M Amorini, Antonio Belli, Marco Cimatti, Roberto Delfini, Valentina Di Pietro, Antonino Finocchiaro, Giuseppe Lazzarino
OBJECTIVE: In the present study, we investigated the occurrence of oxidative and nitrosative stresses in rats undergoing repeat mild traumatic brain injury (mTBI) delivered with increasing time intervals. METHODS: Rats were subjected to two diffuse mTBIs (450 g/1 m height), with the second mTBI delivered after 1 (n = 6), 2 (n = 6), 3 (n = 6), 4 (n = 6), or 5 days (n = 6). The rats were sacrificed 48 hours after the last mTBI. Sham-operated animals were used as controls (n = 6)...
August 2007: Neurosurgery
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