keyword
MENU ▼
Read by QxMD icon Read
search

Feedforward

keyword
https://www.readbyqxmd.com/read/29473541/a-kinase-dependent-feedforward-loop-affects-crebb-stability-and-long-term-memory-formation
#1
Pei-Tseng Lee, Guang Lin, Wen-Wen Lin, Fengqiu Diao, Benjamin H White, Hugo J Bellen
In Drosophila , long-term memory (LTM) requires the cAMP-dependent transcription factor CREBB, expressed in the mushroom bodies (MB) and phosphorylated by PKA. To identify other kinases required for memory formation, we integrated Trojan exons encoding T2A-GAL4 into genes encoding putative kinases and selected for genes expressed in MB. These lines were screened for learning/memory deficits using UAS-RNAi knockdown based on an olfactory aversive conditioning assay. We identified a novel, conserved kinase, Meng-Po ( MP , CG11221 , SBK1 in human), the loss of which severely affects 3 hr memory and 24 hr LTM, but not learning...
February 23, 2018: ELife
https://www.readbyqxmd.com/read/29470055/unique-molecular-regulation-of-higher-order-prefrontal-cortical-circuits-insights-into-the-neurobiology-of-schizophrenia
#2
Dibyadeep Datta, Amy F T Arnsten
Schizophrenia is associated with core deficits in cognitive abilities and impaired functioning of the newly evolved prefrontal association cortex (PFC). In particular, neuropathological studies of schizophrenia have found selective atrophy of the pyramidal cell microcircuits in deep layer III of the dorsolateral PFC (dlPFC), and compensatory weakening of related GABAergic interneurons. Studies in monkeys have shown that recurrent excitation in these layer III microcircuits generates the precisely patterned, persistent firing needed for working memory and abstract thought...
February 22, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29458971/continuous-fractional-order-zero-phase-error-tracking-control
#3
Lu Liu, Siyuan Tian, Dingyu Xue, Tao Zhang, YangQuan Chen
A continuous time fractional-order feedforward control algorithm for tracking desired time varying input signals is proposed in this paper. The presented controller cancels the phase shift caused by the zeros and poles of controlled closed-loop fractional-order system, so it is called Fractional-Order Zero Phase Tracking Controller (FZPETC). The controlled systems are divided into two categories i.e. with and without non-cancellable (non-minimum-phase) zeros which stand in unstable region or on stability boundary...
February 16, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29453207/hippocampal-ripple-oscillations-and-inhibition-first-network-models-frequency-dynamics-and-response-to-gaba-modulators
#4
José R Donoso, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
Hippocampal ripples are involved in memory consolidation, but the mechanisms underlying their generation remain unclear. Models relying on interneuron networks in the CA1 region disagree on the predominant source of excitation to interneurons: either 'direct', via the Schaffer collaterals that provide feedforward input from CA3 to CA1, or 'indirect', via the local pyramidal cells in CA1, which are embedded in a recurrent excitatory-inhibitory network. Here, we used physiologically constrained computational models of basket-cell networks to investigate how they respond to different conditions of transient, noisy excitation...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29450239/alcohol-related-mental-imagery-the-effects-of-a-priming-dose-in-at-risk-drinkers
#5
Michael Yates, Sunjeev K Kamboj
Objectives: Drug related mental imagery is proposed to play a central role in addictive behaviour. However, little is known about such cognition or how it is pharmacologically modulated. Here, we test theoretical predictions of the 'elaborated intrusion' theory by comparing neutral with alcohol related mental imagery, and examine the effects of low dose alcohol on phenomenological aspects of this imagery. Methods: Alcohol related and neutral imagery was assessed after at risk drinkers (n = 40) consumed alcohol (0...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29447252/low-back-electromyography-emg-data-driven-load-classification-for-dynamic-lifting-tasks
#6
Deema Totah, Lauro Ojeda, Daniel D Johnson, Deanna Gates, Emily Mower Provost, Kira Barton
OBJECTIVE: Numerous devices have been designed to support the back during lifting tasks. To improve the utility of such devices, this research explores the use of preparatory muscle activity to classify muscle loading and initiate appropriate device activation. The goal of this study was to determine the earliest time window that enabled accurate load classification during a dynamic lifting task. METHODS: Nine subjects performed thirty symmetrical lifts, split evenly across three weight conditions (no-weight, 10-lbs and 24-lbs), while low-back muscle activity data was collected...
2018: PloS One
https://www.readbyqxmd.com/read/29441004/reverse-engineering-tone-deafness-disrupting-pitch-matching-by-creating-temporary-dysfunctions-in-the-auditory-motor-network
#7
Anja Hohmann, Psyche Loui, Charles H Li, Gottfried Schlaug
Perceiving and producing vocal sounds are important functions of the auditory-motor system and are fundamental to communication. Prior studies have identified a network of brain regions involved in pitch production, specifically pitch matching. Here we reverse engineer the function of the auditory perception-production network by targeting specific cortical regions (e.g., right and left posterior superior temporal (pSTG) and posterior inferior frontal gyri (pIFG)) with cathodal transcranial direct current stimulation (tDCS)-commonly found to decrease excitability in the underlying cortical region-allowing us to causally test the role of particular nodes in this network...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29439729/application-of-neural-networks-for-classification-of-patau-edwards-down-turner-and-klinefelter-syndrome-based-on-first-trimester-maternal-serum-screening-data-ultrasonographic-findings-and-patient-demographics
#8
Aida Catic, Lejla Gurbeta, Amina Kurtovic-Kozaric, Senad Mehmedbasic, Almir Badnjevic
BACKGROUND: The usage of Artificial Neural Networks (ANNs) for genome-enabled classifications and establishing genome-phenotype correlations have been investigated more extensively over the past few years. The reason for this is that ANNs are good approximates of complex functions, so classification can be performed without the need for explicitly defined input-output model. This engineering tool can be applied for optimization of existing methods for disease/syndrome classification. Cytogenetic and molecular analyses are the most frequent tests used in prenatal diagnostic for the early detection of Turner, Klinefelter, Patau, Edwards and Down syndrome...
February 13, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29426634/model-based-directional-analysis-of-cardiovascular-variability-identifies-patients-developing-atrial-fibrillation-after-coronary-artery-bypass-grafting
#9
Vlasta Bari, Marco Ranucci, Beatrice De Maria, Beatrice Cairo, Valeria Pistuddi, Alberto Porta
BACKGROUND: Postoperative atrial fibrillation (AF) might be favored by cardiovascular control impairment. We hypothesize that cardiovascular regulation indexes derived from directional model-based analysis of the spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) can identify subjects at risk to develop AF after coronary artery bypass graft (CABG) surgery. METHODS: Beat-to-beat HP and SAP series were derived from electrocardiogram (ECG) and invasive arterial pressure recorded for 5 min just before CABG surgery in conscious condition...
February 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29425490/fast-spiking-interneurons-supply-feedforward-control-of-bursting-calcium-and-plasticity-for-efficient-learning
#10
Scott F Owen, Joshua D Berke, Anatol C Kreitzer
Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrophysiology, imaging, and behavior to describe a unified mechanism by which striatal FSIs control burst firing, calcium influx, and synaptic plasticity in neighboring medium spiny projection neurons (MSNs)...
February 8, 2018: Cell
https://www.readbyqxmd.com/read/29422148/the-role-of-job-satisfaction-work-engagement-self-efficacy-and-agentic-capacities-on-nurses-turnover-intention-and-patient-satisfaction
#11
Silvia De Simone, Anna Planta, Gianfranco Cicotto
BACKGROUND: Nurses' voluntary turnover is a worrying global phenomenon which affects service quality. Retaining nursing staff within a hospital is important to eliminate the negative influence of voluntary turnover on the quality of care and organisation costs. OBJECTIVES: This research helps explain nurses' voluntary turnover by analysing the role of self-efficacy, agentic capacities, job satisfaction, and work engagement on hospital turnover intention, and to study the relationships between these variables and patient satisfaction...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29420933/precisely-timed-nicotinic-activation-drives-sst-inhibition-in-neocortical-circuits
#12
Joanna Urban-Ciecko, Jean-Sebastien Jouhanneau, Stephanie E Myal, James F A Poulet, Alison L Barth
Sleep, waking, locomotion, and attention are associated with cell-type-specific changes in neocortical activity. The effect of brain state on circuit output requires understanding of how neuromodulators influence specific neuronal classes and their synapses, with normal patterns of neuromodulator release from endogenous sources. We investigated the state-dependent modulation of a ubiquitous feedforward inhibitory motif in mouse sensory cortex, local pyramidal (Pyr) inputs onto somatostatin (SST)-expressing interneurons...
February 7, 2018: Neuron
https://www.readbyqxmd.com/read/29402958/cell-fate-in-antiviral-response-arises-in-the-crosstalk-of-irf-nf-%C3%AE%C2%BAb-and-jak-stat-pathways
#13
Maciej Czerkies, Zbigniew Korwek, Wiktor Prus, Marek Kochańczyk, Joanna Jaruszewicz-Błońska, Karolina Tudelska, Sławomir Błoński, Marek Kimmel, Allan R Brasier, Tomasz Lipniacki
The innate immune system processes pathogen-induced signals into cell fate decisions. How information is turned to decision remains unknown. By combining stochastic mathematical modelling and experimentation, we demonstrate that feedback interactions between the IRF3, NF-κB and STAT pathways lead to switch-like responses to a viral analogue, poly(I:C), in contrast to pulse-like responses to bacterial LPS. Poly(I:C) activates both IRF3 and NF-κB, a requirement for induction of IFNβ expression. Autocrine IFNβ initiates a JAK/STAT-mediated positive-feedback stabilising nuclear IRF3 and NF-κB in first responder cells...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29397957/a-novel-dual-closed-loop-control-scheme-based-on-repetitive-control-for-grid-connected-inverters-with-an-lcl-filter
#14
Yun-Guang Gao, Fa-Yang Jiang, Jian-Cheng Song, Li-Jun Zheng, Fei-Yan Tian, Pu-Long Geng
Grid-connected inverters with LCL filters need high steady-state control accuracy, fast dynamic response performance, and strong robustness to guarantee the power quality. However, there are many problems in traditional control strategies that restrict improvements to control system performance, such as poor dynamic performance of traditional single-repetitive control, large ripples, low steady-state accuracy of inverter current feedback based repetitive dual-loop control or grid-current feedback based single-loop proportional-integral control...
February 2, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29390642/effects-of-topologies-on-signal-propagation-in-feedforward-networks
#15
Jia Zhao, Ying-Mei Qin, Yan-Qiu Che
We systematically investigate the effects of topologies on signal propagation in feedforward networks (FFNs) based on the FitzHugh-Nagumo neuron model. FFNs with different topological structures are constructed with same number of both in-degrees and out-degrees in each layer and given the same input signal. The propagation of firing patterns and firing rates are found to be affected by the distribution of neuron connections in the FFNs. Synchronous firing patterns emerge in the later layers of FFNs with identical, uniform, and exponential degree distributions, but the number of synchronous spike trains in the output layers of the three topologies obviously differs from one another...
January 2018: Chaos
https://www.readbyqxmd.com/read/29387993/perceptual-judgments-via-sensory-motor-interaction-assisted-by-cortical-gaba
#16
Osamu Hoshino, Meihong Zheng, Kazuo Watanabe
Recurrent input to sensory cortex, via long-range reciprocal projections between motor and sensory cortices, is essential for accurate perceptual judgments. GABA levels in sensory cortices correlate with perceptual performance. We simulated a neuron-astrocyte network model to investigate how top-down, feedback signaling from a motor network (Nmot) to a sensory network (Nsen) affects perceptual judgments in association with ambient (extracellular) GABA levels. In the Nsen, astrocytic transporters modulated ambient GABA levels around pyramidal cells...
January 31, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29384452/modeling-auditory-visual-evoked-eye-head-gaze-shifts-in-dynamic-multi-steps
#17
Bahadir Kasap, A John Van Opstal
In dynamic visual or auditory gaze double-steps, a brief target flash or sound burst is presented in midflight of an intervening eye-head gaze shift. Behavioral experiments in humans and monkeys have indicated that the subsequent eye- and head movements to the target are goal-directed, regardless stimulus timing, first gaze-shift characteristics, and initial conditions. This remarkable behavior requires that the gaze-control system (i) has continuous access to accurate signals about eye-in-head position, and ongoing eye-head movements, (ii) that it accounts for different internal signal delays, and (iii) that it is able to update the retinal (TE) and head-centric (TH) target coordinates into appropriate eye-centered and head-centered motor commands on millisecond time scales...
January 31, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29382868/error-gated-hebbian-rule-a-local-learning-rule-for-principal-and-independent-component-analysis
#18
Takuya Isomura, Taro Toyoizumi
We developed a biologically plausible unsupervised learning algorithm, error-gated Hebbian rule (EGHR)-β, that performs principal component analysis (PCA) and independent component analysis (ICA) in a single-layer feedforward neural network. If parameter β = 1, it can extract the subspace that major principal components span similarly to Oja's subspace rule for PCA. If β = 0, it can separate independent sources similarly to Bell-Sejnowski's ICA rule but without requiring the same number of input and output neurons...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29381440/dynamic-neural-turing-machine-with-continuous-and-discrete-addressing-schemes
#19
Caglar Gulcehre, Sarath Chandar, Kyunghyun Cho, Yoshua Bengio
We extend the neural Turing machine (NTM) model into a dynamic neural Turing machine (D-NTM) by introducing trainable address vectors. This addressing scheme maintains for each memory cell two separate vectors, content and address vectors. This allows the D-NTM to learn a wide variety of location-based addressing strategies, including both linear and nonlinear ones. We implement the D-NTM with both continuous and discrete read and write mechanisms. We investigate the mechanisms and effects of learning to read and write into a memory through experiments on Facebook bAbI tasks using both a feedforward and GRU controller...
January 30, 2018: Neural Computation
https://www.readbyqxmd.com/read/29379875/state-based-delay-representation-and-its-transfer-from-a-game-of-pong-to-reaching-and-tracking
#20
Guy Avraham, Raz Leib, Assaf Pressman, Lucia S Simo, Amir Karniel, Lior Shmuelof, Ferdinando A Mussa-Ivaldi, Ilana Nisky
To accurately estimate the state of the body, the nervous system needs to account for delays between signals from different sensory modalities. To investigate how such delays may be represented in the sensorimotor system, we asked human participants to play a virtual pong game in which the movement of the virtual paddle was delayed with respect to their hand movement. We tested the representation of this new mapping between the hand and the delayed paddle by examining transfer of adaptation to blind reaching and blind tracking tasks...
November 2017: ENeuro
keyword
keyword
86626
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"