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Lior Greenbaum, Ramit Ravona-Springer, Abigail Livny, Shahar Shelly, Inbal Sharvit-Ginon, Ithamar Ganmore, Anna Alkelai, Anthony Heymann, Michal Schnaider Beeri
OBJECTIVES: Recent large-scale meta-analysis of genome-wide association studies (GWAS) from multiple cohorts, demonstrated the association of the single nucleotide polymorphism (SNP) rs17518584, with processing speed (measured by the Digit Symbol Substitution Test (DSST) or the Letter Digit Substitution Test (LDST)), at GWAS significance level. This SNP is located within the cell adhesion molecule 2 (CADM2) gene. We aimed to validate this finding in our sample of 944 cognitively normal Jewish elderly individuals with type 2 diabetes (T2D), a population which is at risk for cognitive decline and dementia...
October 5, 2017: World Journal of Biological Psychiatry
C A Ibrahim-Verbaas, J Bressler, S Debette, M Schuur, A V Smith, J C Bis, G Davies, S Trompet, J A Smith, C Wolf, L B Chibnik, Y Liu, V Vitart, M Kirin, K Petrovic, O Polasek, L Zgaga, C Fawns-Ritchie, P Hoffmann, J Karjalainen, J Lahti, D J Llewellyn, C O Schmidt, K A Mather, V Chouraki, Q Sun, S M Resnick, L M Rose, C Oldmeadow, M Stewart, B H Smith, V Gudnason, Q Yang, S S Mirza, J W Jukema, P L deJager, T B Harris, D C Liewald, N Amin, L H Coker, O Stegle, O L Lopez, R Schmidt, A Teumer, I Ford, N Karbalai, J T Becker, M K Jonsdottir, R Au, Rsn Fehrmann, S Herms, M Nalls, W Zhao, S T Turner, K Yaffe, K Lohman, J C van Swieten, Slr Kardia, D S Knopman, W M Meeks, G Heiss, E G Holliday, P W Schofield, T Tanaka, D J Stott, J Wang, P Ridker, A J Gow, A Pattie, J M Starr, L J Hocking, N J Armstrong, S McLachlan, J M Shulman, L C Pilling, G Eiriksdottir, R J Scott, N A Kochan, A Palotie, Y-C Hsieh, J G Eriksson, A Penman, R F Gottesman, B A Oostra, L Yu, A L DeStefano, A Beiser, M Garcia, J I Rotter, M M Nöthen, A Hofman, P E Slagboom, Rgj Westendorp, B M Buckley, P A Wolf, A G Uitterlinden, B M Psaty, H J Grabe, S Bandinelli, D I Chasman, F Grodstein, K Räikkönen, J-C Lambert, D J Porteous, J F Price, P S Sachdev, L Ferrucci, J R Attia, I Rudan, C Hayward, A F Wright, J F Wilson, S Cichon, L Franke, H Schmidt, J Ding, Ajm de Craen, M Fornage, D A Bennett, I J Deary, M A Ikram, L J Launer, A L Fitzpatrick, S Seshadri, C M van Duijn, T H Mosley
To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase...
February 2016: Molecular Psychiatry
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