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https://www.readbyqxmd.com/read/28934711/alterations-of-larval-photo-dependent-swimming-responses-pdr-new-endpoints-for-rapid-and-diagnostic-screening-of-aquatic-contamination
#1
Luis Colón-Cruz, Lauren Kristofco, Jonathan Crooke-Rosado, Agnes Acevedo, Aranza Torrado, Bryan W Brooks, María A Sosa, Martine Behra
Detection and toxicity assessment of waterborne contaminants are crucial for protecting human health and the environment. Development of easy-to-implement, rapid and cost-effective tools to measure anthropogenic effects on watersheds are critical for responsible management, particularly in times of increasing development and urbanization. Traditionally, environmental toxicology has focused on limited endpoints, such as lethality and fertility, which are directly affecting population levels. However, more sensitive readings are needed to assess sub-lethal effects...
September 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28934710/calcium-availability-but-not-its-content-modulates-metal-toxicity-in-scenedesmus-quadricauda
#2
Jozef Kováčik, Sławomir Dresler
Impact of calcium nutrition (pre-culture on solid medium with standard or elevated Ca dose, i. e. 0.17 and 4.40mM marked as low and high Ca) on acute metal toxicity (Cd, Mn and Pb, 24h of exposure to 10µM) in freshwater green alga Scenedesmus quadricauda was studied. Surprisingly, Ca content differed only slightly between low and high Ca samples and applied metals rather suppressed its amount. Na content was higher in metal-exposed high Ca samples, indicating that Ca/Na ratio may affect accumulation of metals...
September 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28934702/effect-of-methyl-substituents-on-the-electronic-transitions-in-simple-meso-aniline-bodipy-based-dyes-ri-cc2-and-td-cam-b3lyp-computational-investigation
#3
Igor K Petrushenko, Konstantin B Petrushenko
The S0→Si, i=1-5 electronic transitions of four 8-(4-aniline)-BODIPY and four 8-(N,N-dimethyl)-BODIPY dyes, differ by number and position of methyl substituents in the BODIPY frame, were investigated theoretically using ab initio the coupled cluster doubles (CC2) and TD-CAM-B3LYP methods. Methyl substituents in the BODIPY frame and the aniline fragment at the meso position disturb energy of local excitations S0→S1, S0→S3, and S0→S4 weakly in comparison with the fully unsubstituted BODIPY molecule. These transitions in experimental spectra form the most long-wave absorption bands at ca...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28934592/getting-nervous-an-evolutionary-overhaul-for-communication
#4
Frederique Varoqueaux, Dirk Fasshauer
The evolution of a nervous system as a control system of the body's functions is a key innovation of animals. Its fundamental units are neurons, highly specialized cells dedicated to fast cell-cell communication. Neurons pass signals to other neurons, muscle cells, or gland cells at specialized junctions, the synapses, where transmitters are released from vesicles in a Ca(2+)-dependent fashion to activate receptors in the membrane of the target cell. Reconstructing the origins of neuronal communication out of a more simple process remains a central challenge in biology...
September 20, 2017: Annual Review of Genetics
https://www.readbyqxmd.com/read/28934515/utility-of-fluorescence-in-situ-hybridization-panel-for-myelodysplastic-syndrome-in-evaluation-of-cytopenia-in-a-pediatric-hospital-a-5-year-retrospective-review-and-utilization-management
#5
Cynthia T Bunting, Tal Senior, Yehuda Susson, Alethia Rivera, Debra Saxe, Silvia T Bunting
Background: MDS FISH was routinely ordered together with chromosome analysis for patients with cytopenia in our hospital. The utility of MDS FISH in the pediatric population is unknown. Objective: To analyze the utility of fluorescence in situ hybridization panel for myelodysplastic syndrome (MDS FISH) in the management of patients with cytopenia. Methods: We performed a retrospective review over a 5-year period, from 2009 to 2014 to determine whether chromosome analysis (CA) plus MDS FISH added useful information compared to chromosome analysis alone...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934415/first-report-of-urease-activity-in-the-novel-systemic-fungal-pathogen-emergomyces-africanus-a-comparison-with-the-neurotrope-cryptococcus-neoformans
#6
Barbra Lerm, Chris Kenyon, Ilan S Schwartz, Heinrich Kroukamp, Riaan de Witt, Nelesh P Govender, G Sybren de Hoog, Alfred Botha
Cryptococcus neoformans is an opportunistic pathogen responsible for the AIDS-defining illness, cryptococcal meningitis. During the disease process, entry of cryptococcal cells into the brain is facilitated by virulence factors that include urease enzyme activity. A novel species of an Emmonsia-like fungus, recently named Emergomyces africanus, was identified as a cause of disseminated mycosis in HIV-infected persons in South Africa. However, in contrast to C. neoformans, the enzymes produced by this fungus, some of which may be involved in pathogenesis, have not been described...
November 1, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28934332/end-member-modelling-as-a-tool-for-climate-reconstruction-an-eastern-mediterranean-case-study
#7
Sarah Beuscher, Stefan Krüger, Werner Ehrmann, Gerhard Schmiedl, Yvonne Milker, Helge Arz, Hartmut Schulz
The Eastern Mediterranean Sea is a sink for terrigenous sediments from North Africa, Europe and Asia Minor. Its sediments therefore provide valuable information on the climate dynamics in the source areas and the associated transport processes. We present a high-resolution dataset of sediment core M40/4_SL71, which was collected SW of Crete and spans the last ca. 180 kyr. We analysed the clay mineral composition, the grain size distribution within the silt fraction, and the abundance of major and trace elements...
2017: PloS One
https://www.readbyqxmd.com/read/28934295/the-lithic-assemblages-of-donggutuo-nihewan-basin-knapping-skills-of-early-pleistocene-hominins-in-north-china
#8
Shi-Xia Yang, Michael D Petraglia, Ya-Mei Hou, Jian-Ping Yue, Cheng-Long Deng, Ri-Xiang Zhu
Donggutuo (DGT) is one of the richest archaeological localities in the Nihewan Basin of North China, thereby providing key information about the technological behaviours of early hominins in eastern Asia. Although DGT has been subject of multiple excavations and technological studies over the past several decades, few detailed studies on the lithic assemblages have been published. Here we summarize and describe the DGT lithic assemblages, examining stone tool reduction methods and technological skills. DGT dates to ca...
2017: PloS One
https://www.readbyqxmd.com/read/28934276/enhanced-pyruvate-dehydrogenase-activity-improves-cardiac-outcomes-in-a-murine-model-of-cardiac-arrest
#9
Lin Piao, Yong-Hu Fang, Manfred M Kubler, Michael W Donnino, Willard W Sharp
RATIONALE: Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial glucose oxidation, is inhibited by increased expression of PDH kinase (PDK) during ischemia/reperfusion injury. This results in decreased utilization of glucose to generate cellular ATP. Post-cardiac arrest (CA) hypothermia improves outcomes and alters metabolism, but its influence on PDH and PDK activity following CA are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28934190/people-with-the-major-alleles-of-atp2b1-rs17249754-increases-the-risk-of-hypertension-in-high-ratio-of-sodium-and-potassium-and-low-calcium-intakes
#10
J W Daily, B C Kim, M Liu, S Park
It is important to understand what genetic risk factors lead to hypertension and how genotype-specific dietary and lifestyle modification can mitigate the risk of developing hypertension. The ATP2B1 rs17249754 gene, which encodes a calcium pump expressed in vascular smooth muscle was identified as having variants that conferred higher or lower risk of hypertension-with the major allele carriers being increased at risk. However, the effects of dietary intakes on risk of hypertension among carriers of the different alleles have not been fully elucidated...
September 21, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28934144/the-recognition-of-calmodulin-to-the-target-sequence-of-calcineurin-a-novel-binding-mode
#11
Chia-Lin Chyan, Deli Irene, Sin-Mao Lin
Calcineurin (CaN) is a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, which plays essential roles in many cellular and developmental processes. CaN comprises two subunits, a catalytic subunit (CaN-A, 60 kDa) and a regulatory subunit (CaN-B, 19 kDa). CaN-A tightly binds to CaN-B in the presence of minimal levels of Ca(2+), but the enzyme is inactive until activated by CaM. Upon binding to CaM, CaN then undergoes a conformational rearrangement, the auto inhibitory domain is displaced and thus allows for full activity...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28934047/book-review-birks-m-mills-j-2015-grounded-theory-a-practical-guide-2nd-ed-los-angeles-ca-sage
#12
Barbara DiCicco-Bloom
No abstract text is available yet for this article.
October 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28934041/book-review-birks-m-mills-j-2015-grounded-theory-a-practical-guide-2nd-ed-los-angeles-ca-sage
#13
Teresa Hamilton
No abstract text is available yet for this article.
October 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28933978/the-glycosidase-treatment-of-gentianae-scabrae-radix-converts-trifloroside-into-deglucosyltrifloroside-with-an-enhancement-of-antioxidative-effects
#14
Eun-Ju Yang, Ju-Gyeong Lee, Kyung-Sik Song
Herbal medicines were subjected to enzyme reaction by using a commercial glycosidase AMG-300L, and were evaluated for enhancement of their antioxidative activities. The methanolic extract of Gentianae Scabrae Radix (GSR) showed the most dramatic changes after enzyme reaction, as seen in the high-performance liquid chromatography profiles and an increase in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect. Trifloroside (1, TF) was identified as being significantly decreased by enzyme reaction, whereas deglucosyltrifloroside (2, DTF) increased...
September 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28933841/supramolecular-self-assembly-and-dual-switch-vapochromic-vapoluminescent-and-resistive-memory-behaviors-of-amphiphilic-platinum-ii-complexes
#15
Yongguang Li, Ling Chen, Yeye Ai, Eugene Yau-Hin Hong, Alan Kwun-Wa Chan, Vivian Wing-Wah Yam
A series of amphiphilic platinum(II) complexes with tridentate N-donor ligands has been synthesized and characterized. Different supramolecular architectures are constructed using the amphiphilic molecules as the building blocks through the formation of Pt···Pt and π-π stacking interactions in aqueous media. The aggregation-deaggregation-aggregation self-assembly behavior together with obvious spectroscopic changes could be fine-tuned by the addition of THF in aqueous media. More interestingly, one of the complexes is found to show fast response and high selectivity toward alcohol and water vapors with good reversibility, leading to drastic color and luminescence changes, and hence unique dual switching behavior, with the water molecules readily displaced by the alcohol vapor...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933692/a-quantitative-hypermorphic-cngc-allele-confers-ectopic-calcium-flux-and-impairs-cellular-development
#16
David M Chiasson, Kristina Haage, Katharina Sollweck, Andreas Brachmann, Petra Dietrich, Martin Parniske
The coordinated control of Ca(2+) signaling is essential for development in eukaryotes. Cyclic nucleotide-gated channel (CNGC) family members mediate Ca(2+) influx from cellular stores in plants(1-4). Here we report the unusual genetic behavior of a quantitative gain-of-function CNGC mutation (brush) in Lotus japonicus resulting in a leaky tetrameric channel. brush resides in a cluster of redundant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties...
September 21, 2017: ELife
https://www.readbyqxmd.com/read/28933546/rational-design-of-selective-adenine-based-scaffolds-for-inactivation-of-bacterial-histidine-kinases
#17
Manibarsha Goswami, Kaelyn E Wilke, Erin E Carlson
Bacterial histidine kinases (HKs) are quintessential regulatory enzymes found ubiquitously in bacteria. Apart from regulatory roles, they are also involved in the production of virulence factors and conferring resistance to various antibiotics in pathogenic microbes. We have previously reported compounds that inhibit multiple HKs by targeting the conserved catalytic and ATP-binding (CA) domain. Herein, we conduct a detailed structure-activity relationship assessment of adenine-based inhibitors using biochemical and docking methods...
September 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28933148/frequency-selective-photobleaching-as-a-route-to-chromatic-control-in-supramolecular-oled-devices
#18
Yu-Tang Tsai, Hsiang-Fang Liu, Bo-Ji Peng, Kuo-Pi Tseng, Ming-Cheng Kuo, Ken-Tsung Wong, Guillaume Wantz, Lionel Hirsch, Guillaume Raffy, André Del Guerzo, Dario M Bassani
We report a series of molecules that spontaneously self-organize into small electroluminescent domains of sub-micrometer dimensions when dissolved in tetrahydrofuran. The self-assembled spherical aggregates have an average size of 300 nm in diameter and exhibit effient energy transfer from the blue to the green or red component. The aggregates can be chromatically addressed or patterned by selective bleaching the energy acceptor component using a laser source. This allows the fabrication of electroluminescence devices by directly photopatterning the active layer without the need of additional steps...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28932828/acceleration-of-diffusion-in-ethylammonium-nitrate-ionic-liquid-confined-between-parallel-glass-plates
#19
Andrei Filippov, Oleg I Gnezdilov, Nicklas Hjalmarsson, Oleg N Antzutkin, Sergei Glavatskih, István Furó, Mark W Rutland
Diffusion of EAN confined between polar glass plates separated by a few micrometers is higher by a factor of ca. 2 as compared to bulk values. Formation of a new phase, different to the bulk, was suggested.
September 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28932448/a-temperature-dependent-phase-transformation-of-e-2-4-chloro-phen-yl-imino-ace-naphthylen-1-one
#20
Lipiao Bao, Marilyn M Olmstead
The crystal structure determination based on 90 K data of the title imine ligand, C18H10ClNO, revealed non-merohedral twinning with three twin domains. In our experience, this is an indication of an ordering phase transition. Consequently, the structure was redetermined with higher temperature data, and a reversible phase transition was discovered. The higher temperature phase is indeed an ordered structure. At the higher temperature, the 4-chloro-phenyl group has rotated by ca 7° into a crystallographic mirror plane...
July 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
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