keyword
MENU ▼
Read by QxMD icon Read
search

Social defeat

keyword
https://www.readbyqxmd.com/read/29332417/-concise-history-of-toxicology-from-empiric-knowledge-to-science
#1
Anna Tompa, Péter Balázs
Toxicology is a science of poisonings by xenobiotics and endogenous physiological changes. Its empiric roots may be traced back to the emerging of the human race because the most important pledge of our predecessors' survival was the differentiation between eatable and poisonous plants and animals. In the course of social evolution, there were three main fields of using poisons: 1) hunting and warfare, 2) to settle social tensions by avoiding military conflicts through hiding strategy of eliminating enemies by toxic substances, 3) medicines applied first as anti-poisons and later by introducing strong substances to defeat diseases, but paradoxically active euthanasia is also a part of the whole story...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29331615/increased-brain-glucocorticoid-actions-following-social-defeat-in-rats-facilitates-the-long-term-establishment-of-social-subordination
#2
Meltem Weger, Yannick Sevelinges, Jocelyn Grosse, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Carmen Sandi
Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social rank remain scarce. Stress was previously shown to affect the establishment and maintenance of social hierarchies in rats. Likewise, increasing systemic corticosterone levels post-encounter in the emerging subordinate rat facilitates the long-term establishment of social subordination...
January 10, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29321525/exploring-the-consequences-of-social-defeat-stress-and-intermittent-ethanol-drinking-on-dopamine-dynamics-in-the-rat-nucleus-accumbens
#3
Alex L Deal, Joanne K Konstantopoulos, Jeff L Weiner, Evgeny A Budygin
The current study aimed to explore how presynaptic dopamine (DA) function is altered following brief stress episodes and chronic ethanol self-administration and whether these neuroadaptations modify the acute effects of ethanol on DA dynamics. We used fast-scan cyclic voltammetry to evaluate changes in DA release and uptake parameters in rat nucleus accumbens brain slices by analyzing DA transients evoked through single pulse electrical stimulation. Adult male rats were divided into four groups: ethanol-naïve or ethanol drinking (six week intermittent two-bottle choice) and stressed (mild social defeat) or nonstressed...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317595/hippocampal-metabolic-differences-implicate-distinctions-between-physical-and-psychological-stress-in-four-rat-models-of-depression
#4
Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Juncai Pu, Lining Yang, Shuai Yuan, Libo Zhao, Chanjun Zhou, Hanping Zhang, Peng Xie
Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28-30 rats were included in each model of depression (chronic unpredictable mild stress (CUMS); learned helplessness (LH); chronic restraint stress (CRS); or social defeat (SD)). Non-targeted gas chromatography-mass spectrometry was used to profile the metabolic changes in the hippocampus...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29315750/an-examination-of-social-comparison-and-suicide-ideation-through-the-lens-of-the-integrated-motivational-volitional-model-of-suicidal-behavior
#5
Karen Wetherall, Kathryn A Robb, Rory C O'Connor
We aimed to investigate whether negative social comparisons are associated with key components of the integrated motivational-volitional (IMV) model of suicidal behavior. Specifically, we investigated the relationship between negative social comparisons, suicide ideation, defeat, entrapment, socially prescribed perfectionism, and resilience. Adult participants (N = 422) completed an online survey comprised of a range of psychological measures. An initial regression analysis indicated that negative social comparisons were associated with suicide ideation...
January 6, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29309799/circuit-based-frameworks-of-depressive-behaviors-the-role-of-reward-circuitry-and-beyond
#6
REVIEW
Daniel Knowland, Byung Kook Lim
Major depressive disorder (MDD) is a common but serious neuropsychiatric affliction that comprises a diverse set of symptoms such as the inability to feel pleasure, lack of motivation, changes in appetite, and cognitive difficulties. Given the patient to patient symptomatic variability in MDD and differing severities of individual symptoms, it is likely that maladaptive changes in distinct brain areas may mediate discrete symptoms in MDD. The advent and recent surge of studies using viral-genetic approaches have allowed for circuit-specific dissection of networks underlying motivational behavior...
January 5, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29307250/a-novel-adolescent-chronic-social-defeat-model-reverse-resident-intruder-paradigm-rrip-in-male-rats
#7
Kevin M Manz, Wendy A Levine, Joshua C Seckler, Anthony N Iskander, Christian G Reich
Psychosocial stress is linked to the etiology of several neuropsychiatric disorders, including Major Depressive Disorder and Post-Traumatic-Stress-Disorder. Adolescence is a critical neurobehavioral developmental period wherein the maturing nervous system is sensitive to stress-related psychosocial events. The effects of social defeat stress, an animal model of psychosocial stress, on adolescent neurobehavioral phenomena are not well explored. Using the standard Resident-Intruder-Paradigm (RIP), adolescent Long-Evans (LE, residents, n = 100) and Sprague-Dawley (SD, intruders, n = 100) rats interacted for five days to invoke chronic social stress...
January 8, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29289657/effects-of-social-defeat-on-paternal-behavior-and-pair-bonding-behavior-in-male-california-mice-peromyscus-californicus
#8
Alex S Kowalczyk, Randy F Davila, Brian C Trainor
Male parental care is an important social behavior for several mammalian species. Psychosocial stress is usually found to inhibit maternal behavior, but effects on paternal behavior have been less consistent. We tested the effects of social defeat stress on pair bond formation and paternal behavior in the monogamous California mouse (Peromyscus californicus). Social defeat reduced time spent in a chamber with a stranger female during a partner preference test conducted 24h after pairing, but increased latency to the first litter...
December 28, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29288827/antidepressant-like-effects-of-water-extract-of-gastrodia-elata-blume-on-neurotrophic-regulation-in-a-chronic-social-defeat-stress-model
#9
Yu-En Lin, Shao-Ting Chou, Shih-Hang Lin, Kuan-Hung Lu, Suraphan Panyod, Yi-Syuan Lai, Chi-Tang Ho, Lee-Yan Sheen
ETHNOPHARMACOLOGY RELEVANCE: Gastrodia elata Blume (GE) is a traditional Chinese medicine commonly used to treat dizziness, epilepsy, paralysis and some emotional symptoms in east Asia. We previously showed that the water extract of Gastrodia elata Blume (WGE) possesses anti-depression like effects in a forced swimming test and chronic mild stress model. AIM OF THE STUDY: The aim of this study was to investigate the antidepressant-like effects of WGE and potential mechanisms related to brain-derived neurotrophic factor (BDNF) regulation in mice exposed to chronic social defeat stress (CSDS) model...
December 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29278313/interactions-between-psychosocial-stress-and-the-circadian-endogenous-clock
#10
REVIEW
Charlotte Helfrich-Förster
Animals are exposed to regular daily challenges in their environment as well as to unpredictable stressful events, so-called stressors. Both measures require adequate physiological responses that are controlled by the circadian system and the stress system. The two systems are highly linked with each other. The circadian system prepares the animal for the regular daily challenges by upregulating the stress system before the animal's activity phase every day. In addition, unpredicted environmental challenges upregulate the stress system independently of the circadian system...
December 2017: PsyCh Journal
https://www.readbyqxmd.com/read/29276735/circuit-and-synaptic-mechanisms-of-repeated-stress-perspectives-from-differing-contexts-duration-and-development
#11
REVIEW
Kevin G Bath, Scott J Russo, Kristen E Pleil, Eric S Wohleb, Ronald S Duman, Jason J Radley
The current review is meant to synthesize research presented as part of a symposium at the 2016 Neurobiology of Stress workshop in Irvine California. The focus of the symposium was "Stress and the Synapse: New Concepts and Methods" and featured the work of several junior investigators. The presentations focused on the impact of various forms of stress (altered maternal care, binge alcohol drinking, chronic social defeat, and chronic unpredictable stress) on synaptic function, neurodevelopment, and behavioral outcomes...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/29261497/-studying-episodic-memory-dogs-as-a-biological-model
#12
Charlotte Duranton, Sarah Jeannin, Thierry Bedossa, Florence Gaunet
The ability to remember past events in all of their dimensions (what? where? when? i.e. autobiographic/episodic memory) is highly adaptive. Conversely, individuals who do not have such ability are less likely to benefit from recognizing situations similar to previous ones, e.g. to avoid being defeated several times. We will present the different types of memory and their ontogeny, focusing on those that are found in dogs. We will then describe more precisely the episodic memory, i.e. remembering events or actions from others, and their location and the time of the events and will present to which degree such a skill is found in dogs...
December 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29249803/possible-role-of-the-gut-microbiota-brain-axis-in-the-antidepressant-effects-of-r-ketamine-in-a-social-defeat-stress-model
#13
Chun Yang, Youge Qu, Yuko Fujita, Qian Ren, Min Ma, Chao Dong, Kenji Hashimoto
Accumulating evidence suggests that the gut microbiota-brain axis plays a role in the pathogenesis of depression, thereby contributing to the antidepressant actions of certain compounds. (R)-ketamine has a greater potency and longer-lasting antidepressant effects than (S)-ketamine. Here, we investigated whether the gut microbiota plays a role in the antidepressant effects of these two ketamine enantiomers. The role of the gut microbiota in the antidepressant effects of ketamine enantiomers in a chronic social defeat stress (CSDS) model of depression was examined using 16S ribosomal RNA gene sequencing of fecal samples...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29234278/effects-of-social-defeat-stress-on-sleep-in-mice
#14
Fiona Henderson, Vincent Vialou, Salah El Mestikawy, Véronique Fabre
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance states in C57Bl/6J male mice. Social behavior was assessed to identify susceptible mice, i.e., mice that develop long-lasting social avoidance, and unsusceptible mice...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29228014/a-model-for-warfare-in-stratified-small-scale-societies-the-effect-of-within-group-inequality
#15
Sagar Pandit, Gauri Pradhan, Carel van Schaik
In order to predict the features of non-raiding human warfare in small-scale, socially stratified societies, we study a coalitionary model of war that assumes that individuals participate voluntarily because their decisions serve to maximize fitness. Individual males join the coalition if war results in a net economic and thus fitness benefit. Within the model, viable offensive war ensues if the attacking coalition of males can overpower the defending coalition. We assume that the two groups will eventually fuse after a victory, with ranks arranged according to the fighting abilities of all males and that the new group will adopt the winning group's skew in fitness payoffs...
2017: PloS One
https://www.readbyqxmd.com/read/29221793/pannexin-1-channel-dysfunction-in-the-medial-prefrontal-cortex-mediates-depressive-like-behaviors-induced-by-chronic-social-defeat-stress-and-administration-of-mefloquine-in-mice
#16
Ming Ni, Jin-Gang He, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu
Mefloquine (MFQ) is widely used for the treatment of malaria clinically. Apart from antimalarial effect, psychiatric side effects such as depression and anxiety of MFQ have been reported. Interestingly, MFQ is also known as a broad-spectrum pannexin-1 (Panx1) inhibitor. Panx1 is a new gap junction channel expressed in the brain which mediates efflux of adenosine triphosphate (ATP). Although exogenous ATP has been known to produce a potential antidepressant-like effect, little is known about the role of Panx1 in pathophysiology of depression, especially the depression induced by administration of MFQ...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29206007/christian-psychopathology-psychiatry-and-knowledge-for-the-sake-of-salvation-in-the-early-years-of-francoism
#17
Ángel González de Pablo
After World War II came to an end, General Franco's regime attempted to step aside from the defeated fascist states by emphasizing its Catholic character. The change of image culminated in 1947 with the establishment of Spain as a Catholic State by means of the Law of Succession. This process generated the national catholic ideology, which became, during the first decades of the dictatorship, the hegemonic instrument for the transformation of Spanish society in an anti-modernizing way. Scientific activity was not excluded from these changes, and a Catholic science conveying universal values and in harmony with the faith was strongly encouraged...
2017: Dynamis
https://www.readbyqxmd.com/read/29195162/effects-of-adolescent-social-stress-and-antidepressant-treatment-on-cognitive-inflexibility-and-bdnf-epigenetic-modifications-in-the-mpfc-of-adult-mice
#18
Hang Xu, Jiesi Wang, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao, Weiwen Wang
Adolescent social stress (ASS) can increase susceptibility to depression in adulthood. However, the underlying psychological and neural mechanisms remain unclear. Cortically mediated cognitive dysfunctions are increasingly recognized as an independent and important risk factor of depression. Using social defeat stress, a classical animal model of depression, our previous studies found that mice subjected to this form of stress during early adolescence displayed cognitive inflexibility (CI) in adulthood. This change was accompanied by a down-regulation of Bdnf gene expression in the medial prefrontal cortex (mPFC); this gene encodes a key molecule involved in depression and antidepressant action...
November 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29186765/to-group-or-not-to-group-good-practice-for-housing-male-laboratory-mice
#19
REVIEW
(no author information available yet)
It is widely recommended to group-house male laboratory mice because they are 'social animals', but male mice do not naturally share territories and aggression can be a serious welfare problem. Even without aggression, not all animals within a group will be in a state of positive welfare. Rather, many male mice may be negatively affected by the stress of repeated social defeat and subordination, raising concerns about welfare and also research validity. However, individual housing may not be an appropriate solution, given the welfare implications associated with no social contact...
November 24, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29186377/oxytocin-oxytocin-receptor-systems-facilitate-social-defeat-posture-in-male-mice
#20
Naranbat Nasanbuyan, Masahide Yoshida, Yuki Takayanagi, Ayumu Inutsuka, Katsuhiko Nishimori, Akihiro Yamanaka, Tatsushi Onaka
Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics, i.e., social defeat stress, evokes species-specific defeat posture via unknown mechanisms. Oxytocin neurons have been shown to be activated by stressful stimuli and to have pro-social and anxiolytic actions. The roles of oxytocin during social defeat stress remain unclear. Expression of c-Fos, a marker of neuronal activation, in oxytocin neurons and in oxytocin receptor-expressing neurons was investigated in mice...
November 24, 2017: Endocrinology
keyword
keyword
8661
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"