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https://www.readbyqxmd.com/read/29771569/prestige-in-a-large-scale-social-group-predicts-longitudinal-changes-in-testosterone
#1
Joey T Cheng, Olga Kornienko, Douglas A Granger
In many social species, organisms adaptively fine-tune their competitive behavior in response to previous experiences of social status: Individuals who have prevailed in the past preferentially compete in the future, whereas those who have suffered defeat tend to defer and submit. A growing body of evidence suggests that testosterone functions as a "competition hormone" that coordinates this behavioral plasticity through its characteristic rise and fall following victory and defeat. Although well demonstrated in competitions underpinned by dominance (fear-based status derived from force and intimidation), this pattern has not been examined in status contests that depend solely on prestige-respect-based status derived from success, skills, and knowledge in locally valued domains, devoid of fear or antagonism...
June 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29768187/activation-of-kappa-opioid-receptors-in-the-dorsal-raphe-have-sex-dependent-effects-on-social-behavior-in-california-mice
#2
Emily C Wright, Tiffany V Parks, Jonathon O Alexander, Rajesh Supra, Brian C Trainor
Kappa opioid receptor activation has been linked to stress and anxiety behavior, thus leading to kappa antagonists being popularized in research as potential anxiolytics. However, while these findings may hold true in standard models, the neuromodulatory effects of social defeat may change the behavioral outcome of kappa opioid receptor activation. Previous research has shown that social defeat can lead to hyperactivity of serotonergic neurons in the dorsal raphe nucleus, and that inhibition of this increase blocks the social deficits caused by defeat...
May 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29757081/-the-great-fiasco-of-the-1948-presidential-election-polls-status-recognition-and-norms-conflict-in-social-science
#3
Dominic Lusinchi
All three 'scientific' pollsters (Crossley, Gallup and Roper) wrongly predicted incumbent President Harry Truman's defeat in the 1948 presidential election, and thus faced a potentially serious legitimacy crisis. This 'fiasco' occurred at a most inopportune time. Social science was embroiled in a policy debate taking place in the halls of Congress. It was fighting a losing battle to be included, along with the natural sciences, in the National Science Foundation, for which legislation was being drafted. Faced with the failure of the polls, the Social Science Research Council (SSRC) intervened quickly to prevent social science's adversaries from using this event to degrade further its status...
May 14, 2018: Annals of Science
https://www.readbyqxmd.com/read/29740291/varying-social-experiences-in-adulthood-do-not-differentially-affect-anxiety-like-behavior-but-stress-hormone-levels
#4
Niklas Kästner, S Helene Richter, Carina Bodden, Rupert Palme, Sylvia Kaiser, Norbert Sachser
Social experiences can have profound effects on an individual's level of anxiety. While various studies have addressed consequences of experiences of a specific type, e.g., social defeat, a recent study in mice investigated the impact of combinations of adverse and beneficial social experiences. Quite surprisingly, mice exposed to benefits during early life phases followed by escapable adversity in adulthood displayed lowest levels of anxiety, even compared to individuals having experienced throughout beneficial conditions...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29717159/neural-and-behavioural-correlates-of-repeated-social-defeat
#5
Julie M Butler, Sarah M Whitlow, David A Roberts, Karen P Maruska
Dominance hierarchies are common across the animal kingdom and have important consequences for reproduction and survival. Animals of lower social status cope with repeated social defeat using proactive and reactive behaviours. However, there remains a paucity of information on how an individual's coping behaviours changes over time or what neural mechanisms are involved. We used a resident-intruder paradigm in the African cichlid fish Astatotilapia burtoni to investigate the neural correlates of these two opposing behaviour groups...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29696309/persistent-escalation-of-alcohol-consumption-by-mice-exposed-to-brief-episodes-of-social-defeat-stress-suppression-by-crf-r1-antagonism
#6
Emily L Newman, Lucas Albrechet-Souza, Peter M Andrew, John G Auld, Kelly C Burk, Lara S Hwa, Eric Y Zhang, Joseph F DeBold, Klaus A Miczek
RATIONALE: Episodic bouts of social stress can precede the initiation, escalation, or relapse to disordered alcohol intake. Social stress may engender neuroadaptations in the hypothalamic-pituitary-adrenal (HPA) axis and in extrahypothalamic stress circuitry to promote the escalation of alcohol intake. OBJECTIVES: We aimed to (1) confirm a pattern of escalated drinking in socially defeated mice and to (2) test drugs that target distinct aspects of the HPA axis and extrahypothalamic neural substrates for their effectiveness in reducing murine, stress-escalated drinking...
June 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29694918/psychosocial-stress-delays-recovery-of-postoperative-pain-following-incisional-surgery-in-the-rat
#7
Vipin Arora, Thomas J Martin, Carol A Aschenbrenner, Kenichiro Hayashida, Susy A Kim, Renee A Parker, James C Eisenach, Christopher M Peters
Psychosocial factors such as anxiety, depression and catastrophizing, commonly associated with established chronic pain, also may be associated with an increased risk of chronic postsurgical pain (CPSP) when present preoperatively. We used a repeat social defeat (RSD) paradigm to induce psychosocial stress in rodents prior to incisional surgery of the paw. Mixed effects growth curve models were utilized to examine resolution of mechanical hypersensitivity in rats for four weeks following surgery. Eight days following surgery, immunohistochemistry was conducted to examine glial activation as well as evoked neuronal activation in the spinal cord...
April 22, 2018: Neuroscience
https://www.readbyqxmd.com/read/29681795/delta-opioid-receptor-signaling-promotes-resilience-to-stress-under-the-repeated-social-defeat-paradigm-in-mice
#8
Mathilde S Henry, Kanchan Bisht, Nathalie Vernoux, Louis Gendron, Angélica Torres-Berrio, Guy Drolet, Marie-Ève Tremblay
The adaptation to chronic stress is highly variable across individuals. Resilience to stress is a complex process recruiting various brain regions and neurotransmitter systems. The aim of this study was to investigate the involvement of endogenous opioid enkephalin (ENK) signaling in the development of stress resilience in mice. The translational model of repeated social defeat (RSD) stress was selected to mimic the unpredictable disruptions of daily life and induce resilience or vulnerability to stress. As in humans, adult C57BL/6J mice demonstrated a great variability in their response to stress under this paradigm...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29679052/differential-contribution-of-cis-and-trans-gene-transcription-regulatory-mechanisms-in-amygdala-and-prefrontal-cortex-and-modulation-by-social-stress
#9
Eli Reuveni, Dmitry Getselter, Oded Oron, Evan Elliott
While both individual transcription factors and cis-acting sites have been studied in relation to psychiatric disorders, there is little knowledge of the relative contribution of trans-acting and cis-acting factors to gene transcription in the brain. Using an RNA-seq approach in mice bred from two evolutionary-distinct mice strains, we determined the contribution of cis and trans factors to gene expression in the prefrontal cortex and amygdala, two regions of the brain relevant to the stress response, and the contribution of cis and trans factors in the prefrontal cortex after Chronic Social Defeat (CSD) in mice...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674218/single-aggressive-and-non-aggressive-social-interactions-elicit-distinct-behavioral-patterns-to-the-context-in-mice
#10
Ariela M Crestani, Ana C Cipriano, Ricardo L Nunes-de-Souza
Aggressive interactions between conspecific animals have been used as a social stressor with ethological characteristics to study how social interactions can modulate animal's behavior. Here, a new protocol based on aggressive and non-aggressive interactions was developed to study how different social interactions can alter the behavioral profile of animals re-exposed to the context in which the interaction occurred. We used factor analysis to trace the behavioral profile of socially defeated and non-defeated mice when they were re-exposed to the apparatus [three interconnected chambers: home chamber, tunnel and surface area]; we also compared the behavior presented before (habituation) and 24 hours after (re-exposure) the non-aggressive or aggressive interactions...
April 16, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29673593/augmented-neutrophil-extracellular-traps-formation-promotes-atherosclerosis-development-in-socially-defeated-apoe-mice
#11
Keita Yamamoto, Hiroyuki Yamada, Noriyuki Wakana, Masakazu Kikai, Kensuke Terada, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Kami, Takehiro Ogata, Masakazu Ibi, Chihiro Yabe-Nishimura, Satoaki Matoba
Depression is an independent risk factor of cardiovascular disease (CVD); however, the causal association remains undefined. We exposed mice to repeated social defeat (RSD) to precipitate depressive-like behaviors, and investigated the effects on atherosclerosis. Eight-week-old male apoE-/- mice were exposed to RSD by housing with a larger CD-1 mouse in a shared home cage. They were subjected to vigorous physical contact daily for 10 consecutive days and fed a high-cholesterol diet (HCD) for 6 weeks. The social interaction ratio and immobility time showed dramatic social avoidance before and after HCD feeding...
June 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29662948/reduced-orexin-system-function-contributes-to-resilience-to-repeated-social-stress
#12
Laura A Grafe, Darrell Eacret, Jane Dobkin, Seema Bhatnagar
Exposure to stress increases the risk of developing affective disorders such as depression and post-traumatic stress disorder (PTSD). However, these disorders occur in only a subset of individuals, those that are more vulnerable to the effects of stress, whereas others remain resilient. The coping style adopted to deal with the stressor, either passive or active coping, is related to vulnerability or resilience, respectively. Important neural substrates that mediate responses to a stressor are the orexins. These neuropeptides are altered in the cerebrospinal fluid of patients with stress-related illnesses such as depression and PTSD...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29660975/synergistic-effects-of-psychosocial-stress-and-mild-peripheral-infection-on-inducing-microglial-activation-in-the-hippocampal-dentate-gyrus-and-long-lasting-deficits-in-hippocampus-related-memory
#13
Wen-Yu Tzeng, Chien-Chou Su, Li-Han Sun, Chianfang G. Cherng, Lung Yu
Lipopolysaccharide (LPS) treatment and stress may cause immune activation in the brain, an event which has been thought to play a role in mediating stress-induced cognitive dysfunction. However, the enduring impact of psychosocial stress on brain immune activation or cognitive deficits has not been well investigated. Likewise, it remains unexplored whether there exist synergistic effects of psychosocial stress and a weak systemic LPS treatment on brain immune activation and/or cognitive function. In this work, a 10-day social defeat regimen was used to model psychosocial stress and the number and density of ionized calcium-binding adaptor molecule 1 (Iba1)-stained microglia was used to reveal brain immune activation in male Balb/C mice...
April 17, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29623033/aggression-social-stress-and-the-immune-system-in-humans-and-animal-models
#14
REVIEW
Aki Takahashi, Meghan E Flanigan, Bruce S McEwen, Scott J Russo
Social stress can lead to the development of psychological problems ranging from exaggerated anxiety and depression to antisocial and violence-related behaviors. Increasing evidence suggests that the immune system is involved in responses to social stress in adulthood. For example, human studies show that individuals with high aggression traits display heightened inflammatory cytokine levels and dysregulated immune responses such as slower wound healing. Similar findings have been observed in patients with depression, and comorbidity of depression and aggression was correlated with stronger immune dysregulation...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29618006/dysfunction-of-serotoninergic-and-dopaminergic-neuronal-systems-in-the-antidepressant-resistant-impairment-of-social-behaviors-induced-by-social-defeat-stress-exposure-as-juveniles
#15
Sho Hasegawa, Yuriko Miyake, Akira Yoshimi, Akihiro Mouri, Hirotake Hida, Kiyofumi Yamada, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda
Background: Extensive studies have been performed on the role of monoaminergic neuronal systems in rodents exposed to social defeat stress as adults. In the present study, we investigated the role of monoaminergic neuronal systems in the impairment of social behaviors induced by social defeat stress exposure as juveniles. Methods: Juvenile, male C57BL/6J mice were exposed to social defeat stress for 10 consecutive days. From 1 day after the last stress exposure, desipramine, sertraline, and aripiprazole, were administered for 15 days...
March 29, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29615190/ventral-ca3-activation-mediates-prophylactic-ketamine-efficacy-against-stress-induced-depressive-like-behavior
#16
Alessia Mastrodonato, Randy Martinez, Ina P Pavlova, Christina T LaGamma, Rebecca A Brachman, Alfred J Robison, Christine A Denny
BACKGROUND: We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown. METHODS: Here, we tested whether prophylactic ketamine administration altered neural activity in the prefrontal cortex and/or hippocampus. Mice were injected with saline or ketamine (30 mg/kg) 1 week before social defeat...
February 23, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29595517/parental-perception-of-terminology-of-disorders-of-sex-development-in-western-turkey-running-head-parental-perception-of-dsd-terminology
#17
Sibel Tiryaki, Ali Tekin, Ismail Yagmur, Samim Özen, Burcu Özbaran, Damla Gökşen, Şükran Darcan, İbrahim Ulman, Ali Avanoğlu
OBJECTIVE: "Disorders of sex development (DSD)" is a nomenclature proposed to defeat the discomfort of families and patients and has found worldwide usage. The aim of this study is addressing the perception and usage of terminology among the parents of DSD patients in a tertiary center in western Turkey. METHODS: The records of the DSD council between years 2008-2015 were reviewed retrospectively and data including details of the management process, patient characteristics and follow-up details were noted...
March 29, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29593501/chronic-stress-reduces-nectin-1-mrna-levels-and-disrupts-dendritic-spine-plasticity-in-the-adult-mouse-perirhinal-cortex
#18
Qian Gong, Yun-Ai Su, Chen Wu, Tian-Mei Si, Jan M Deussing, Mathias V Schmidt, Xiao-Dong Wang
In adulthood, chronic exposure to stressful experiences disrupts synaptic plasticity and cognitive function. Previous studies have shown that perirhinal cortex-dependent object recognition memory is impaired by chronic stress. However, the stress effects on molecular expression and structural plasticity in the perirhinal cortex remain unclear. In this study, we applied the chronic social defeat stress (CSDS) paradigm and measured the mRNA levels of nectin-1, nectin-3 and neurexin-1, three synaptic cell adhesion molecules (CAMs) implicated in the adverse stress effects, in the perirhinal cortex of wild-type (WT) and conditional forebrain corticotropin-releasing hormone receptor 1 conditional knockout (CRHR1-CKO) mice...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29580891/repeated-social-stress-leads-to-contrasting-patterns-of-structural-plasticity-in-the-amygdala-and-hippocampus
#19
D Patel, S Anilkumar, S Chattarji, B Buwalda
Previous studies have demonstrated that repeated immobilization and restraint stress cause contrasting patterns of dendritic reorganization as well as alterations in spine density in amygdalar and hippocampal neurons. Whether social and ethologically relevant stressors can induce similar patterns of morphological plasticity remains largely unexplored. Hence, we assessed the effects of repeated social defeat stress on neuronal morphology in basolateral amygdala (BLA), hippocampal CA1 and infralimbic medial prefrontal cortex (mPFC)...
March 23, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29577194/cytokine-production-by-splenic-cells-in-c57bl-6j-mice-with-depression-like-behavior-depends-on-the-duration-of-social-stress
#20
G V Idova, E V Markova, M M Gevorgyan, E L Al'perina, S Ya Zhanaeva
We studied the influence of depression-like behavior developed in C57BL/6J mice under conditions of social stress of different duration on cytokine production by splenic cells. Imbalance of the pro- and anti-inflammatory cytokines was detected at the early stage of depression-like behavior (10-day experience of defeats): increased production of proinflammatory IL-2 and IL-6 cytokines along with a decrease in anti-inflammatory IL-10 level; the levels of IL-1β, TNFα, IFNγ, and IL-4 remained unaffected. At later terms (20 days of confrontations), we revealed more pronounced changes in spontaneous production of proinflammatory cytokines that were not detected after shorter social stress...
March 26, 2018: Bulletin of Experimental Biology and Medicine
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