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Social defeat

Julie E Finnell, Brandon L Muniz, Akhila R Padi, Calliandra M Lombard, Casey M Moffitt, Christopher S Wood, L Britt Wilson, Lawrence P Reagan, Marlene A Wilson, Susan K Wood
BACKGROUND: Women are at greater risk than men of developing depression and comorbid disorders such as cardiovascular disease. This enhanced risk begins at puberty and ends following menopause, suggesting a role for ovarian hormones in this sensitivity. Here we used a model of psychosocial witness stress in female rats to determine the stress-induced neurobiological adaptations that underlie stress susceptibility in an ovarian hormone-dependent manner. METHODS: Intact or ovariectomized (OVX) female rats were exposed to five daily 15-minute witness-stress exposures...
January 31, 2018: Biological Psychiatry
Zhi-Fang Deng, Hui-Ling Zheng, Jian-Guo Chen, Yi Luo, Jun-Feng Xu, Gang Zhao, Jia-Jing Lu, Hou-Hong Li, Shuang-Qi Gao, Deng-Zheng Zhang, Ling-Qiang Zhu, Yong-Hui Zhang, Fang Wang
β-Catenin has been implicated in major depressive disorder (MDD), which is associated with synaptic plasticity and dendritic arborization. MicroRNAs (miRNA) are small noncoding RNAs containing about 22 nucleotides and involved in a variety of physiological and pathophysiological process, but their roles in MDD remain largely unknown. Here, we investigated the expression and function of miRNAs in the mouse model of chronic social defeat stress (CSDS). The regulation of β-catenin by selected miRNA was validated by silico prediction, target gene luciferase reporter assay, and transfection experiment in neurons...
March 7, 2018: Cerebral Cortex
Jorge Tovar-Díaz, Matthew B Pomrenze, Russell Kan, Bahram Pahlavan, Hitoshi Morikawa
Stressful events rapidly trigger activity-dependent synaptic plasticity, driving the formation of aversive memories. However, it remains unclear how stressful experience affects plasticity mechanisms to regulate appetitive learning, such as intake of addictive drugs. Using rats, we show that corticotropin-releasing factor (CRF) and α1 adrenergic receptor (α1AR) signaling enhance the plasticity of NMDA-receptor-mediated glutamatergic transmission in ventral tegmental area (VTA) dopamine (DA) neurons through distinct effects on inositol 1,4,5-triphosphate (IP3 )-dependent Ca2+ signaling...
March 6, 2018: Cell Reports
Kai Zhang, Yuko Fujita, Kenji Hashimoto
Since the metabolism of (R,S)-ketamine to (2R,6R)-hydroxynorketamine (HNK) is reported to be essential for ketamine's antidepressant effects, there is an increasing debate about antidepressant effects of (2R,6R)-HNK. Using pharmacokinetic and behavioral techniques, we investigated whether intracerebroventricular (i.c.v.) infusion of (R)-ketamine or (2R,6R)-HNK show antidepressant effects in a chronic social defeat stress (CSDS) model of depression. Low levels of (2R,6R)-HNK in the brain after i.c.v. infusion of (R)-ketamine were detected, although brain levels of (2R,6R)-HNK were markedly lower than those after i...
March 5, 2018: Scientific Reports
Rainbo Hultman, Kyle Ulrich, Benjamin D Sachs, Cameron Blount, David E Carlson, Nkemdilim Ndubuizu, Rosemary C Bagot, Eric M Parise, Mai-Anh T Vu, Neil M Gallagher, Joyce Wang, Alcino J Silva, Karl Deisseroth, Stephen D Mague, Marc G Caron, Eric J Nestler, Lawrence Carin, Kafui Dzirasa
Brain-wide fluctuations in local field potential oscillations reflect emergent network-level signals that mediate behavior. Cracking the code whereby these oscillations coordinate in time and space (spatiotemporal dynamics) to represent complex behaviors would provide fundamental insights into how the brain signals emotional pathology. Using machine learning, we discover a spatiotemporal dynamic network that predicts the emergence of major depressive disorder (MDD)-related behavioral dysfunction in mice subjected to chronic social defeat stress...
March 1, 2018: Cell
Sara S Fernandes, André P Koth, Gustavo M Parfitt, Marcos F Cordeiro, Carolina S Peixoto, Andréa Soubhia, Fernanda P Moreira, Carolina D Wiener, Jean P Oses, Erikson Kaszubowski, Daniela M Barros
Major depressive disorder has a heterogeneous etiology, since it arises from the interaction of multiple factors and different pathophysiological mechanisms are involved in the symptomatology. This study aimed to investigate the role of the cholinergic system in the susceptibility to stress and, consequently, in the depression-like behavior. C57BL/6 mice were treated with Physostigmine (PHYS), an acetylcholinesterase (AChE) inhibitor, and were submitted to the social defeat stress. For the behavioral evaluation of the locomotor activity, anxiety-like and depression-like behaviors the open field, elevated plus maze, sucrose preference, social interaction and forced swim were used...
March 1, 2018: Behavioural Brain Research
S Ya Zhanaeva, A A Rogozhnikova, E L Alperina, M M Gevorgyan, G V Idov
We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations...
March 3, 2018: Bulletin of Experimental Biology and Medicine
Jennifer Blaze, Jun Wang, Lap Ho, Natalia Mendelev, Fatemeh Haghighi, Giulio Maria Pasinetti
SCOPE: Stress is a known contributor to various forms of disease in humans and animals, although mechanisms are still unknown. In animals, psychosocial stress-induced depression/anxiety phenotypes are coincidental with increased inflammation in both brain and blood. We recently showed that a novel treatment with a select bioactive polyphenol preparation promotes resilience to stress-mediated depression/anxiety phenotypes mice. Moreover, we identified selective bioactive phenolic compounds within the polyphenol preparation that were effective in mitigating the behavioral effects of bone marrow transplantation from stressed mice...
February 22, 2018: Molecular Nutrition & Food Research
Rody C Kingston, Michael Smith, Tiara Lacey, Malcolm Edwards, Janae N Best, Chris M Markham
Exposure to social stressors can cause profound changes in an individual's well-being and can be an underlying factor in the etiology of a variety of psychopathologies, such as post-traumatic stress disorder (PTSD). In Syrian hamsters, a single social defeat experience results in behavioral changes collectively known as conditioned defeat (CD), and includes an abolishment of territorial aggression and the emergence of high levels of defensive behaviors. In contrast, voluntary exercise has been shown to promote stress resilience and can also have anxiolytic-like effects...
February 5, 2018: Physiology & Behavior
Guy Griebel, Jeanne Stemmelin, Mati Lopez-Grancha, Valérie Fauchey, Franck Slowinski, Philippe Pichat, Gihad Dargazanli, Ahmed Abouabdellah, Caroline Cohen, Olivier E Bergis
Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the eCB anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). This study describes a potent reversible FAAH inhibitor, SSR411298. The drug acts as a selective inhibitor of FAAH, which potently increases hippocampal levels of AEA, OEA and PEA in mice. Despite elevating eCB levels, SSR411298 did not mimic the interoceptive state or produce the behavioral side-effects (memory deficit and motor impairment) evoked by direct-acting cannabinoids...
February 5, 2018: Scientific Reports
Lisa Janet Cohen, Bernard Gorman, Jessica Briggs, Min Eun Jeon, Tal Ginsburg, Igor Galynker
In this study, we introduce the construct of the suicidal narrative, a hypothetical personal narrative linked to imminent suicide, and explore its relationship to near-term suicidal risk and the suicide crisis syndrome (SCS). Psychiatric outpatients (N = 289) were administered the Columbia Suicide-Severity Rating Scale (C-SSRS), Suicide Crisis Inventory (SCI), and Suicide Narrative Inventory (SNI), a novel instrument combining the documented risk factors of Thwarted Belongingness, Perceived Burdensomeness, Humiliation, Social Defeat, Goal Disengagement, and Goal Reengagement...
February 4, 2018: Suicide & Life-threatening Behavior
Carmen Ferrer-Pérez, Marina D Reguilón, Carmen Manzanedo, M Asunción Aguilar, José Miñarro, Marta Rodríguez-Arias
Numerous studies have shown that social defeat stress induces an increase in the rewarding effects of cocaine. In this study we have investigated the role played by the main hypothalamic stress hormone, corticotropin-releasing factor (CRF), in the effects that repeated social defeat (RSD) induces in the conditioned rewarding effects and locomotor sensitization induced by cocaine. A total of 220 OF1 mice were divided into experimental groups according to the treatment received before each social defeat: saline, 5 or 10mg/kg of the nonpeptidic corticotropin-releasing factor CRF1 receptor antagonist CP-154,526, or 15 or 30µg/kg of the peptidic corticotropin-releasing factor CRF2 receptor antagonist Astressin2-B...
January 29, 2018: European Journal of Pharmacology
Anzela Niraula, Yufen Wang, Jonathan P Godbout, John F Sheridan
Repeated social defeat (RSD) stress promotes the release of bone marrow-derived monocytes into circulation that are recruited to the brain, where they augment neuroinflammation and cause prolonged anxiety-like behavior. Physiological stress activates the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal gland (HPA) axis, and both of these systems play a role in the physiological, immunological, and behavioral responses to stress. The purpose of this study was to delineate the role of HPA activation and corticosterone production in the immunological responses to stress in male C57/BL6 mice...
January 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Vikram Patel, Jonathan K Burns, Monisha Dhingra, Leslie Tarver, Brandon A Kohrt, Crick Lund
Most countries have witnessed a dramatic increase of income inequality in the past three decades. This paper addresses the question of whether income inequality is associated with the population prevalence of depression and, if so, the potential mechanisms and pathways which may explain this association. Our systematic review included 26 studies, mostly from high-income countries. Nearly two-thirds of all studies and five out of six longitudinal studies reported a statistically significant positive relationship between income inequality and risk of depression; only one study reported a statistically significant negative relationship...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Benjamin D Sachs, Ha L Tran, Emily Folse, Marc G Caron
The association between stress and mental illness has been well documented, but the molecular consequences of repeated exposure to stress have not been completely identified. The present study sought to elucidate the combinatorial effects of early life maternal separation stress and adult social defeat stress on alterations in signal transduction and gene expression that have been previously implicated in susceptibility to psychosocial stress. Molecular analyses were performed in the prelimbic/infralimbic cortex, amygdala, and nucleus accumbens, three brain regions that have been suggested to play critical roles in determining stress responses...
January 13, 2018: Neuroscience
Mitra Heshmati, Hossein Aleyasin, Caroline Menard, Daniel J Christoffel, Meghan E Flanigan, Madeline L Pfau, Georgia E Hodes, Ashley E Lepack, Lucy K Bicks, Aki Takahashi, Ramesh Chandra, Gustavo Turecki, Mary Kay Lobo, Ian Maze, Sam A Golden, Scott J Russo
Behavioral coping strategies are critical for active resilience to stress and depression; here we describe a role for neuroligin-2 (NLGN-2) in the nucleus accumbens (NAc). Neuroligins (NLGN) are a family of neuronal postsynaptic cell adhesion proteins that are constituents of the excitatory and inhibitory synapse. Importantly, NLGN-3 and NLGN-4 mutations are strongly implicated as candidates underlying the development of neuropsychiatric disorders with social disturbances such as autism, but the role of NLGN-2 in neuropsychiatric disease states is unclear...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
Akihiro Mouri, Mayu Ukai, Mizuki Uchida, Sho Hasegawa, Masayuki Taniguchi, Takahiro Ito, Hirotake Hida, Akira Yoshimi, Kiyofumi Yamada, Shohko Kunimoto, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda
Adverse juvenile experiences, including physical abuse, often have negative health consequences later in life. We investigated the influence of social defeat stress exposure as juveniles on neuropsychological behaviors, and the causal role of glucocorticoids in abnormal behaviors and impairment of neurogenesis in mice exposed to the stress. The juvenile (24-day-old) and adult (70-day-old) male C57BL/6J mice were exposed to social defeat stress induced by an aggressive ICR mouse. Social defeat stress exposure as juveniles, even for 1 day, induced persistent social avoidance to the unfamiliar ICR mouse in the social interaction test, but that was not observed in mice exposed to the stress as adults...
January 11, 2018: Neuropharmacology
Anna Tompa, Péter Balázs
Toxicology is a science of poisonings by xenobiotics and endogenous physiological changes. Its empiric roots may be traced back to the emerging of the human race because the most important pledge of our predecessors' survival was the differentiation between eatable and poisonous plants and animals. In the course of social evolution, there were three main fields of using poisons: 1) hunting and warfare, 2) to settle social tensions by avoiding military conflicts through hiding strategy of eliminating enemies by toxic substances, 3) medicines applied first as anti-poisons and later by introducing strong substances to defeat diseases, but paradoxically active euthanasia is also a part of the whole story...
January 2018: Orvosi Hetilap
Meltem Weger, Yannick Sevelinges, Jocelyn Grosse, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Carmen Sandi
Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social rank remain scarce. Stress was previously shown to affect the establishment and maintenance of social hierarchies in rats. Likewise, increasing systemic corticosterone levels post-encounter in the emerging subordinate rat facilitates the long-term establishment of social subordination...
January 10, 2018: Physiology & Behavior
Alex L Deal, Joanne K Konstantopoulos, Jeff L Weiner, Evgeny A Budygin
The current study aimed to explore how presynaptic dopamine (DA) function is altered following brief stress episodes and chronic ethanol self-administration and whether these neuroadaptations modify the acute effects of ethanol on DA dynamics. We used fast-scan cyclic voltammetry to evaluate changes in DA release and uptake parameters in rat nucleus accumbens brain slices by analyzing DA transients evoked through single pulse electrical stimulation. Adult male rats were divided into four groups: ethanol-naïve or ethanol drinking (six week intermittent two-bottle choice) and stressed (mild social defeat) or nonstressed...
January 10, 2018: Scientific Reports
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