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https://www.readbyqxmd.com/read/28095998/the-feasibility-and-clinical-benefits-of-improving-facial-affect-recognition-impairments-in-schizophrenia-systematic-review-and-meta-analysis
#1
REVIEW
Natalie Bordon, Suzanne O'Rourke, Paul Hutton
BACKGROUND: People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psychotic symptoms and reduced social functioning. It remains unclear whether this impairment is responsive to non-pharmacological intervention, or what the effect of modifying it is. METHODS: We did a systematic review and meta-analysis to examine whether and to what extent facial affect recognition impairments can be improved by psychological intervention and, if so, whether this leads to improvements in psychotic symptoms and social functioning...
January 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28094034/dynamical-representation-of-dominance-relationships-in-the-human-rostromedial-prefrontal-cortex
#2
Romain Ligneul, Ignacio Obeso, Christian C Ruff, Jean-Claude Dreher
Humans and other primates have evolved the ability to represent their status in the group's social hierarchy, which is essential for avoiding harm and accessing resources. Yet it remains unclear how the human brain learns dominance status and adjusts behavior accordingly during dynamic social interactions. Here we address this issue with a combination of fMRI and transcranial direct current stimulation (tDCS). In a first fMRI experiment, participants learned an implicit dominance hierarchy while playing a competitive game against three opponents of different skills...
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/28092086/anxiety-related-behaviours-associated-with-microrna-206-3p-and-bdnf-expression-in-pregnant-female-mice-following-psychological-social-stress
#3
Zhuang Miao, Fengbiao Mao, Jialong Liang, Moshe Szyf, Yan Wang, Zhong Sheng Sun
Stress during pregnancy can induce various psychological disorders in women. However, the association linking psychological stress during pregnancy with abnormal behaviours in females remains largely unknown. We employed a novel psychological stress model by introducing pregnant mice to witness the defeat process of their mated partner (WDPMP) and examined the effects of WDPMP on depression-/anxiety-like behaviours and on the expression of brain-derived neurotrophic factor (BDNF) and miR-206-3p in the hippocampus, medial prefrontal cortex (mPFC) and amygdala...
January 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28076550/suicide-in-university-students-in-bogot%C3%A3-colombia-2004-2014
#4
Saúl Alonso Franco, Martha Lucia Gutiérrez, Julián Sarmiento, Decsy Cuspoca, Javier Tatis, Alejandro Castillejo, Miguel Barrios, Magnolia Del Pilar Ballesteros-Cabrera, Sara Zamora, Carlos Iván Rodríguez
We report the results of a retrospective, descriptive, qualitative study of suicide among university students in Bogotá, Colombia. The objective of this study was to document the magnitude, principal characteristics, and impact of this phenomenon in the selected population. A semi-structured survey was employed to collect information from 66 individuals linked to the universities. A total of 45 cases of suicide were documented in the study period (2004 - 2014). Of these, 69% occurred in males and 31% in females...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28074830/tet1-in-nucleus-accumbens-opposes-depression-and-anxiety-like-behaviors
#5
Jian Feng, Catherine J Pena, Immanuel Purushothaman, Olivia Engmann, Deena Walker, Amber N Brown, Orna Issler, Marie Doyle, Eileen Harrigan, Ezekiell Mouzon, Vincent Vialou, Li Shen, Meelad M Dawlaty, Rudolf Jaenisch, Eric J Nestler
Depression is a leading cause of disease burden, yet current therapies fully treat <50% of affected individuals. Increasing evidence implicates epigenetic mechanisms in depression and antidepressant action. Here, we examined a possible role for the DNA dioxygenase, ten eleven translocation protein 1 (TET1), in depression-related behavioral abnormalities. We applied chronic social defeat stress, an ethologically validated mouse model of depression-like behaviors, and examined Tet1 expression changes in nucleus accumbens (NAc), a key brain reward region...
January 11, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28073366/oral-treatment-with-lactobacillus-rhamnosus-attenuates-behavioural-deficits-and-immune-changes-in-chronic-social-stress
#6
Aadil Bharwani, M Firoz Mian, Michael G Surette, John Bienenstock, Paul Forsythe
BACKGROUND: Stress-related disorders involve systemic alterations, including disruption of the intestinal microbial community. Given the putative connections between the microbiota, immunity, neural function, and behaviour, we investigated the potential for microbe-induced gut-to-brain signalling to modulate the impact of stress on host behaviour and immunoregulation. METHODS: Male C57BL/6 mice treated orally over 28 days with either Lactobacillus rhamnosus (JB-1) ™ or vehicle were subjected to chronic social defeat and assessed for alterations in behaviour and immune cell phenotype...
January 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28071753/de-novo-assembly-annotation-and-characterization-of-the-whole-brain-transcriptome-of-male-and-female-syrian-hamsters
#7
Katharine E McCann, David M Sinkiewicz, Alisa Norvelle, Kim L Huhman
Hamsters are an ideal animal model for a variety of biomedical research areas such as cancer, virology, circadian rhythms, and behavioural neuroscience. The use of hamsters has declined, however, most likely due to the dearth of genetic tools available for these animals. Our laboratory uses hamsters to study acute social stress, and we are beginning to investigate the genetic mechanisms subserving defeat-induced behavioural change. We have been limited, however, by the lack of genetic resources available for hamsters...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068856/effects-of-ethanol-on-social-avoidance-induced-by-chronic-social-defeat-stress-in-mice
#8
Cristiane A Favoretto, Giovana C Macedo, Isabel M H Quadros
In rodents, chronic social defeat stress promotes deficits in social interest and social interaction. We further explored these anti-social effects by comparing the consequences of two different defeat stress protocols (episodic vs. continuous stress) in a social investigation test. We expected that continuous, but not episodic, stress would induce social deficits in this model. Furthermore, we tested whether a potentially anxiolytic dose of ethanol reverses social deficits induced by defeat stress. Male Swiss mice were exposed to a 10-day social defeat protocol, using daily confrontations with an aggressive resident mouse...
January 9, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28067904/prefrontal-cortical-control-of-a-brainstem-social-behavior-circuit
#9
Tamara B Franklin, Bianca A Silva, Zinaida Perova, Livia Marrone, Maria E Masferrer, Yang Zhan, Angie Kaplan, Louise Greetham, Violaine Verrechia, Andreas Halman, Sara Pagella, Alexei L Vyssotski, Anna Illarionova, Valery Grinevich, Tiago Branco, Cornelius T Gross
The prefrontal cortex helps adjust an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas, and selective inhibition of these projections mimicked the behavioral effects of social defeat...
January 9, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28058270/validity-assessment-of-5-day-repeated-forced-swim-stress-to-model-human-depression-in-young-adult-c57bl-6j-and-balb-cj-mice
#10
Joram D Mul, Jia Zheng, Laurie J Goodyear
The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent model is the 5 d repeated forced swim stress (5d-RFSS) paradigm, which progressively increases floating during individual swim sessions. The onset and persistence of this floating behavior has been anthropomorphically characterized as a measure of depression. This interpretation has been under debate because a progressive increase in floating over time may reflect an adaptive learned behavioral response promoting survival, and not depression (Molendijk and de Kloet, 2015)...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28053019/biological-mechanisms-whereby-social-exclusion-may-contribute-to-the-etiology-of-psychosis-a-narrative-review
#11
Jean-Paul Selten, Jan Booij, Bauke Buwalda, Andreas Meyer-Lindenberg
The purpose of this review is to examine whether a contribution of social exclusion to the pathogenesis of psychosis is compatible with the dopamine hypothesis and/or the neurodevelopmental hypothesis. Humans experience social exclusion as defeating. An animal model for defeat is the resident-intruder paradigm. The defeated animal shows evidence of an increased sensitivity to amphetamine, increased dopamine release in the nucleus accumbens and prefrontal cortex, and increased firing of dopaminergic neurons in the ventral tegmental area...
January 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28025089/histone-deacetylase-5-modulates-the-effects-of-social-adversity-in-early-life-on-cocaine-induced-behavior
#12
Alessandro Valzania, Clarissa Catale, Maria Teresa Viscomi, Stefano Puglisi-Allegra, Valeria Carola
Psychostimulants induce stable changes in neural plasticity and behavior in a transcription-dependent manner. Further, stable cellular changes require transcription that is regulated by epigenetic mechanisms that alter chromatin structure, such as histone acetylation. This mechanism is typically catalyzed by enzymes with histone acetyltransferase or histone deacetylase (HDAC) activity. Class IIa HDACs are notable for their high expression in important regions of the brain reward circuitry and their neural activity-dependent shuttling in and out of the cell nucleus...
December 23, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28018190/disruption-of-the-glutamate-glutamine-cycle-involving-astrocytes-in-an-animal-model-of-depression-for-males-and-females
#13
Virginie Rappeneau, Amanda Blaker, Jeff R Petro, Bryan K Yamamoto, Akiko Shimamoto
Background: Women are twice as likely as men to develop major depression. The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-glutamine cycle involving astrocytes using an animal model of depression. Methods: Male and female adult Long-Evans rats were exposed to chronic social defeat stress (CSDS) for 21 days, using a modified resident-intruder paradigm...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28013484/antidepressant-like-effects-of-ginsenoside-rg3-in-mice-via-activation-of-the-hippocampal-bdnf-signaling-cascade
#14
Zhengchen You, Qi Yao, Jianhong Shen, Zhikai Gu, Hui Xu, Zhonghua Wu, Chuanjun Chen, Luozhu Li
Current antidepressants are clinically effective only after several weeks of administration. Ginsenoside Rg3 is one component of ginsenosides, with a similar chemical structure to ginsenoside Rg1. Here, we investigated the antidepressant effects of Rg3 in mouse models of depression. The antidepressant actions of Rg3 were first examined in the forced swim test (FST) and tail suspension test (TST), and then assessed in the chronic social defeat stress (CSDS) model of depression. The changes in the hippocampal brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and Rg3 treatment were investigated...
December 24, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27991542/adjunctive-treatment-of-brexpiprazole-with-fluoxetine-shows-a-rapid-antidepressant-effect-in-social-defeat-stress-model-role-of-bdnf-trkb-signaling
#15
Min Ma, Qian Ren, Chun Yang, Ji-Chun Zhang, Wei Yao, Chao Dong, Yuta Ohgi, Takashi Futamura, Kenji Hashimoto
Addition of low doses of the atypical antipsychotic drug brexpiprazole with selective serotonin reuptake inhibitors (SSRIs) could promote antidepressant effect in patients with major depressive disorder although the precise mechanisms underlying the action of the combination are unknown. Combination of low dose of brexpiprazole (0.1 mg/kg) and SSRI fluoxetine (10 mg/kg) could promote a rapid antidepressant effect in social defeat stress model although brexpiprazole or fluoxetine alone did not show antidepressant effect...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27981196/social-defeat-stress-induces-depression-like-behavior-and-alters-spine-morphology-in-the-hippocampus-of-adolescent-male-c57bl-6-mice
#16
Sergio D Iñiguez, Antonio Aubry, Lace M Riggs, Jason B Alipio, Roseanna M Zanca, Francisco J Flores-Ramirez, Mirella A Hernandez, Steven J Nieto, David Musheyev, Peter A Serrano
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined the behavioral, morphological, and biochemical effects of the social defeat stress model of depression on hippocampal dendritic spines within the CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to defeat episodes for 10 consecutive days...
December 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27981183/sex-differences-in-sleep-anhedonia-and-hpa-axis-activity-in-a-rat-model-of-chronic-social-defeat
#17
Gayle G Page, Mark R Opp, Sharon L Kozachik
Repeated bouts of a major stressor such as social defeat are well known to induce a depression phenotype in male rats. Despite strong evidence and acknowledgement that women have a two-fold lifetime greater risk of developing major depression compared to men, the inclusion of female rats in studies employing social defeat are very rare; their absence is attributed to less aggressive interactions. This study sought to compare in male and female rats the impact of repeated social defeat, three times per week for four weeks, on the development of changes in sleep architecture and continuity, sucrose preference as a measure of anhedonia, changes in body weight, and basal plasma corticosterone levels...
June 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27956741/role-of-the-adipose-ppar%C3%AE-adiponectin-axis-in-susceptibility-to-stress-and-depression-anxiety-related-behaviors
#18
M Guo, C Li, Y Lei, S Xu, D Zhao, X-Y Lu
Adaptive responses to stressful stimuli involving behavioral, emotional and metabolic changes are orchestrated by the nervous and endocrine systems. Adipose tissue has been recognized as a highly active metabolic and endocrine organ, secreting adipokines that operate as hormones to mediate the crosstalk with other organs including the brain. The role of adipose tissue in sensing and responding to emotional stress and in behavioral regulation, however, remains largely unknown. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a key transcriptional factor controlling adipokine gene expression...
December 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27939810/the-acute-social-defeat-stress-and-nest-building-test-paradigm-a-potential-new-method-to-screen-drugs-for-depressive-like-symptoms
#19
Hikari Otabi, Tatsuhiko Goto, Tsuyoshi Okayama, Daisuke Kohari, Atsushi Toyoda
Psychosocial stress can cause mental conditions such as depression in humans. To develop drug therapies for the treatment of depression, it is necessary to use animal models of depression to screen drug candidates that exhibit anti-depressive effects. Unfortunately, the present methods of drug screening for antidepressants, the forced-swim test and tail-suspension test, are limiting factors in drug discovery because they are not based on the constructive validity of objective phenotypes in depression. Previously, we discovered that the onset of nest building is severely delayed in mice exposed to subchronic mild social defeat stress (sCSDS)...
December 7, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27913257/prodynorphin-and-kappa-opioid-receptor-mrna-expression-in-the-brain-relates-to-social-status-and-behavior-in-male-european-starlings
#20
Lauren V Riters, Melissa A Cordes, Sharon A Stevenson
Numerous animal species display behavioral changes in response to changes in social status or territory possession. For example, in male European starlings only males that acquire nesting sites display high rates of sexual and agonistic behavior. Past studies show that mu and delta opioid receptors regulate behaviors associated with social ascension or defeat. Opioids also act at kappa receptors, with dynorphin binding with the highest affinity; however, the role of these opioids in social behavior has not been well studied...
March 1, 2017: Behavioural Brain Research
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