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https://www.readbyqxmd.com/read/29665430/awareness-of-cervical-cancer-and-willingness-to-be-vaccinated-against-human-papillomavirus-in-mozambican-adolescent-girls
#1
Azucena Bardají, Carolina Mindu, Orvalho J Augusto, Aina Casellas, Olga Cambaco, Egas Simbine, Graça Matsinhe, Eusébio Macete, Clara Menéndez, Esperança Sevene, Khátia Munguambe
Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction of the HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted in Mozambique prior to the first round of the HPV vaccine demonstration programme. It targeted girls aged 10-19 years old identified from schools and households. Face-to-face structured interviews were conducted. A total of 1,147 adolescents were enrolled in three selected districts of the country...
April 14, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29663734/new-biological-research-and-understanding-of-papanicolaou-s-test
#2
REVIEW
Elizabeth R Smith, Sophia H George, Erin Kobetz, Xiang-Xi Xu
The development of the Papanicolaou smear test by Dr. George Nicholas Papanicolaou (1883-1962) is one of the most significant achievements in screening for disease and cancer prevention in history. The Papanicolaou smear has been used for screening of cervical cancer since the 1950s. The test is technically straightforward and practical and based on a simple scientific observation: malignant cells have an aberrant nuclear morphology that can be distinguished from benign cells. Here, we review the scientific understanding that has been achieved and continues to be made on the causes and consequences of abnormal nuclear morphology, the basis of Dr...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29660141/carbonic-anhydrase-is-not-a-relevant-nitrite-reductase-or-nitrous-anhydrase-in-the-lung
#3
Philipp A Pickerodt, Sebastian Kronfeldt, Martin Russ, Adrian Gonzalez-Lopez, Philipp Lother, Elvira Steiner, Katja Vorbrodt, Thilo Busch, Willehad Boemke, Roland C E Francis, Erik R Swenson
The carbonic anhydrase (CA) inhibitors, acetazolamide and its structurally similar analogue, methazolamide prevent or reduce hypoxic pulmonary vasoconstriction (HPV) in dogs and humans in vivo, by a mechanism unrelated to CA inhibition. In rodent blood and isolated blood vessels, Aamand et al. (2009) reported that inhibition of CA led to increased generation of nitric oxide (NO) from nitrite and vascular relaxation in vitro. We tested the physiological relevance of augmented NO generation by CA from nitrite with acetazolamide in anaesthetized pigs during alveolar hypoxia in vivo...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29652958/-hpv-vaccine-implementation-in-chile-an-appraisal-from-the-social-determinants-of-health-model
#4
Loreto Fernández González
Cervical cancer is the fourth most common neoplasm in women worldwide and its incidence is associated with profound social inequities. In Chile, it is the second cause of death in women of reproductive age. The Chilean clinical guideline identifies the vaccine against Human Papillomavirus (HPV) as the main preventive measure. Since 2014, the Ministry of Health has implemented free immunization against HPV for girls and female adolescents. This article critically analyzes this public policy from the viewpoint of health equity, using as framework the Social Determinants of Health Model...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29628765/low-rate-of-human-papillomavirus-vaccination-among-schoolgirls-in-lebanon-barriers-to-vaccination-with-a-focus-on-mothers-knowledge-about-available-vaccines
#5
Maria J Abou El-Ola, Mariam A Rajab, Dania I Abdallah, Ismail A Fawaz, Lyn S Awad, Hani M Tamim, Ahmad O Ibrahim, Anas M Mugharbil, Rima A Moghnieh
Background: Human papillomavirus (HPV) infection is an established predisposing factor of cervical cancer. In this study, we assessed the awareness about genital warts, cervical cancer, and HPV vaccine among mothers having girls who are at the age of primary HPV vaccination attending a group of schools in Lebanon. We also assessed the rate of HPV vaccination among these girls and the barriers to vaccination in this community. Subjects and methods: This is a cross-sectional, school-based survey...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29625768/human-papillomavirus-vaccine-acceptability-and-decision-making-among-adolescent-boys-and-parents-a-meta-ethnography-of-qualitative-studies
#6
REVIEW
Ashley Lacombe-Duncan, Peter A Newman, Philip Baiden
OBJECTIVE: Genital warts and human papillomavirus (HPV)-associated cancers in men can be substantially reduced through HPV vaccination; yet, globally, HPV vaccine uptake among boys remains low. This meta-ethnography synthesizes qualitative studies to understand, in-depth, HPV vaccine acceptability and decision-making among adolescent boys and/or their parents. METHODS: A systematic search identified qualitative studies examining HPV vaccines from the perspectives of boys and/or boys' parents...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29616673/knowledge-of-sexually-transmitted-infections-and-sex-at-risk-among-italian-students-of-health-professions-data-from-a-one-month-survey
#7
Omar Enzo Santangelo, Sandro Provenzano, Alberto Firenze
AIM: The aim of the study was to evaluate the knowledge and behavioral risks associated with sexually transmitted infections (STIs) among the students of health professions at the University of Palermo divided into two age groups (18-22 years and 23-27 years). MATERIALS AND METHODS: A self-administered questionnaire was distributed. The questionnaire is structured in three parts in addition to an introduction to socio-demographic information. The first part investigates the quality of information provided by public institutions on the subject, the second part the knowledge of contraceptive methods used to reduce the risk of contagion and the third part the knowledge of STIs and HPV vaccination...
January 2018: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29616651/knowledge-and-practice-of-togolese-women-concerning-cervical-cancer
#8
S Agbo, H S Bemanana, K M Aziagbenyo, F M Lahaye
OBJECTIVE: To identify the determinants of the knowledge and practice of Togolese women concerning cervical cancer. METHODS: This cross-sectional study with a descriptive and analytical focus took place in Togo during the four-month period from May to August 2016 and surveyed women aged 18 to 60 living in the Lomé municipal area for at least 12 months. Sampling of the intervention zones was based on reasoned choice depending on the availability of health structures in the area...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29599358/numerical-imbalances-of-chromosome-7-in-oral-squamous-cell-carcinoma
#9
Nicholas S Mastronikolis, Evangelos Tsiambas, Panagiotis P Fotiades, Evangelia Baliou, Andreas Karameris, Dimitrios Peschos, Stylianos N Mastronikolis, Asimakis D Asimakopoulos, Xenofon Giannakopoulos, Vasileios Ragos
BACKGROUND: Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many chromosomal and gene alterations have been identified in OSCC, including structural and numerical changes. In this study, we implemented a molecular assay of chromosome 7 (Chr7) in order to investigate the level of its numerical instability in OSCC. MATERIALS AND METHODS: Using tissue microarray technology, 30 primary OSCCs were cored and re-embedded into one recipient block. Chromogenic in situ hybridization assay was performed based on Chr7 centromeric probedetection...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29595120/state-of-the-art-on-viral-micrornas-in-hpv-infection-and-cancer-development
#10
Palmiro Poltronieri, Binlian Sun, Kai-Yao Huang, Tzu-Hao Chang, Tzong-Yi Lee
BACKGROUND: high-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHOD: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, presence of hairpins, and validation by comparison with RNA sequencing datasets...
March 27, 2018: MicroRNA
https://www.readbyqxmd.com/read/29593032/extracellular-conformational-changes-in-the-capsid-of-human-papillomaviruses-contribute-to-asynchronous-uptake-into-host-cells
#11
Miriam Becker, Lilo Greune, M Alexander Schmidt, Mario Schelhaas
The human papillomavirus type 16 (HPV16) is the leading cause of cervical cancer. For initial infection, HPV16 utilizes a novel endocytic pathway for host cell entry. Unique amongst viruses, uptake occurs asynchronously over a protracted period of time with half-times between 9-12 h. To trigger endocytic uptake, the virus particles need to undergo a series of structural modifications after initial binding to heparan sulfate proteoglycans (HSPG). These changes involve proteolytic cleavage of the major capsid protein L1 by kallikrein-8 (KLK8), exposure of the N-terminus of the minor capsid protein L2 by cyclophilins, and cleavage of this N-terminus by furin...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29588103/black-mother-s-intention-to-vaccinate-daughters-against-hpv-a-mixed-methods-approach-to-identify-opportunities-for-targeted-communication
#12
Jennifer Cunningham-Erves, Laura Forbes, Nataliya Ivankova, Tilicia Mayo-Gamble, Kendria Kelly-Taylor, Jason Deakings
OBJECTIVE: The cervical cancer disparity continues to exist and has widened between Black and non-Hispanic White women. Human Papillomavirus (HPV) vaccines could potentially reduce this disparity, yet remain underused among Black female adolescents. We investigated psychosocial and cultural factors associated with Black mothers' intentions to vaccinate their daughters against HPV, and explored views toward a HPV vaccine mandate. METHODS: In this quantitative dominant, mixed methods study, cross sectional surveys (n=237) and follow-up semi-structured interviews (n=9) were conducted with Black mothers of daughters...
March 24, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29579309/vifi-accurate-detection-of-viral-integration-and-mrna-fusion-reveals-indiscriminate-and-unregulated-transcription-in-proximal-genomic-regions-in-cervical-cancer
#13
Nam-Phuong D Nguyen, Viraj Deshpande, Jens Luebeck, Paul S Mischel, Vineet Bafna
The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma. We present ViFi, a computational method that combines phylogenetic methods with reference-based read mapping to detect viral integrations. In contrast with read-based reference mapping approaches, ViFi is faster, and shows high precision and sensitivity on both simulated and biological data, even when the integrated virus is a novel strain or highly mutated...
March 20, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29578171/effect-of-smoking-on-high-grade-cervical-cancer-in-women-on-the-basis-of-human-papillomavirus-infection-studies
#14
Jian-Hong Fang, Xue-Mei Yu, Shu-Hong Zhang, Yan Yang
Purpose: We aimed, in the present study, to measure the risk related to the high-grade cervical intraepithelial neoplasia grade 3 (CIN3) or worse (CIN3+) or worse/high-grade squamous intraepithelial lesions with respect to changes in human papillomavirus (HPV) and smoking status. Materials and Methods: A structured interview underwent for 7129 women. Then, we obtained their cervical cells and subjected to HPV testing. High-risk HPV infected and "no prevalent" cervical disease infected women were followed for cervical lesions up to 12 years (at baseline; n = 1531)...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29568922/phylogeny-and-polymorphism-in-the-long-control-regions-e6-e7-and-l1-of-hpv-type-56-in-women-from-southwest-china
#15
Yaling Jing, Tao Wang, Zuyi Chen, Xianping Ding, Jianju Xu, Xuemei Mu, Man Cao, Honghan Chen
Globally, human papillomavirus (HPV)‑56 accounts for a small proportion of all high‑risk HPV types; however, HPV‑56 is detected at a higher rate in Asia, particularly in southwest China. The present study analyzed polymorphisms, intratypic variants, and genetic variability in the long control regions (LCR), E6, E7, and L1 of HPV‑56 (n=75). The LCRs, E6, E7 and L1 were sequenced using a polymerase chain reaction and the sequences were submitted to GenBank. Maximum‑likelihood trees were constructed using Kimura's two‑parameter model, followed by secondary structure analysis and protein damaging prediction...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29558864/factors-protecting-male-and-female-adolescents-in-mexico-from-human-papillomavirus-infection
#16
Claudia Orozco Gómez, Jane Dimmitt Champion, María Guadalupe Moreno Monsiváis
INTRODUCTION: Adolescents may be infected with human papillomavirus (HPV) during their first sexual relationship. Persistent infections in adulthood may result in associated cancers among both women and men. This study explored condom use action plans, its influence on sexual activity in adolescents, and associated HPV protective behavior. METHODS: A descriptive correlational design was used. A convenience sample including adolescents ( N =313; male n = 171, female n = 142), aged 15 to 17 years, attending one of three public high schools in Mexico was recruited...
January 1, 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29548060/-what-can-health-journalism-achieve-a-criterion-based-evaluation-of-print-media-coverage-of-the-hpv-vaccine-in-germany-2006-to-2009
#17
Ann-Kristin Niewald, Carina Oedingen, Oliver Razum
BACKGROUND: In 2006, the first human papillomavirus (HPV) vaccine was licensed in Europe and in 2007 it was included in the service catalogue of the statutory health insurance. The HPV vaccine led to a controversy in public and print media even before it was licensed. We evaluated the quality of the newspaper coverage of the HPV vaccine during the controversy in Germany. METHODS: The LexisNexis print media database was scanned for health journalism articles on HPV in 4 high-circulation national newspapers and 4 magazines using pre-defined search terms for the period 2006-2009...
March 16, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29544466/knowledge-attitudes-and-practices-toward-cervical-cancer-prevention-among-women-in-kampong-speu-province-cambodia
#18
Sothy Touch, Jin-Kyoung Oh
BACKGROUND: There is little information concerning the preventive behaviors against cervical cancer among women in Cambodia, a country without organized cervical cancer screening programs and national human papillomavirus (HPV) vaccination policies. We aimed to examine the cervical cancer knowledge, attitudes, and practices as well as cervical cancer prevention methods among Cambodian women. METHODS: A community-based cross-sectional survey on cervical cancer prevention was conducted...
March 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29535023/e7-oncoprotein-of-human-papillomavirus-structural-dynamics-and-inhibitor-screening-study
#19
Murali Aarthy, Deepak Kumar, Rajanish Giri, Sanjeev Kumar Singh
Human papillomavirus (HPV) has been the primary causative agent of cervical cancer, the most threatening cancer affecting millions of women worldwide. HPV, a small non enveloped DNA virus of high and low risk types contain intrinsically disordered region and it also plays significant role in the development of cervical cancer. HPV E7 contains an ordered Zinc finger motif that binds to pRB and alters its function. It utilizes both disordered N-terminal and structured C-terminal regions for cellular transformation...
March 10, 2018: Gene
https://www.readbyqxmd.com/read/29521462/hpv-primary-cervical-screening-in-england-women-s-awareness-and-attitudes
#20
Hersha Patel, Esther L Moss, Susan M Sherman
BACKGROUND: Primary HPV cervical screening is due to be implemented in England within the next 2years however, the acceptability of HPV testing as the primary screening test is unclear. This study explores women's awareness and attitudes towards HPV testing/screening. METHODS: Qualitative interviews (semi-structured and focus group) were conducted with forty-six women (aged 25-65years) from community and secondary care settings. Data was analysed using the inductive-framework method...
March 9, 2018: Psycho-oncology
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