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https://www.readbyqxmd.com/read/27887796/vaccine-strategies-optimising-outcomes
#1
Karin Hardt, Paolo Bonanni, Susan King, Jose Ignacio Santos, Mostafa El-Hodhod, Gregory D Zimet, Scott Preiss
Successful immunisation programmes generally result from high vaccine effectiveness and adequate uptake of vaccines. In the development of new vaccination strategies, the structure and strength of the local healthcare system is a key consideration. In high income countries, existing infrastructures are usually used, while in less developed countries, the capacity for introducing new vaccines may need to be strengthened, particularly for vaccines administered beyond early childhood, such as the measles or human papillomavirus (HPV) vaccine...
November 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27836727/modulation-of-the-dna-damage-response-during-the-life-cycle-of-human-papillomaviruses
#2
REVIEW
Daniel C Anacker, Cary A Moody
Human papillomavirus (HPV) is the most common sexually transmitted viral infection. Infection with certain types of HPV pose a major public health risk as these types are associated with multiple human cancers, including cervical cancer, other anogenital malignancies and an increasing number of head and neck cancers. The HPV life cycle is closely tied to host cell differentiation with late viral events such as structural gene expression and viral genome amplification taking place in the upper layers of the stratified epithelium...
November 8, 2016: Virus Research
https://www.readbyqxmd.com/read/27816418/papillomavirus-infections-in-the-oral-and-genital-mucosa-of-asymptomatic-women
#3
Ledy Horto Santos Oliveira, Larissa Silva Santos, Carolina Oliveira Silva, Everton Faccini Augusto, Felipe Piedade Gonçalves Neves
Human papillomavirus (HPV) has been found in several regions of the body, including the oral cavity. Recently, this virus has been associated with oropharyngeal cancer, but little is known about HPV transmission to the oral cavity. We carried out a study to investigate concurrent oral and cervical infections in 76 asymptomatic women attending a healthcare program. Demographic and behavior data were obtained through a structured questionnaire. Oral and cervical mucosa scrapings were collected and stored for DNA extraction...
November 2, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27802830/the-vaginal-microbiota-human-papillomavirus-infection-and-cervical-intraepithelial-neoplasia-what-do-we-know-and-where-are-we-going-next
#4
REVIEW
Anita Mitra, David A MacIntyre, Julian R Marchesi, Yun S Lee, Phillip R Bennett, Maria Kyrgiou
The vaginal microbiota plays a significant role in health and disease of the female reproductive tract. Next-generation sequencing techniques based upon the analysis of bacterial 16S rRNA genes permit in-depth study of vaginal microbial community structure to a level of detail not possible with standard culture-based microbiological techniques. The human papillomavirus (HPV) causes both cervical intraepithelial neoplasia (CIN) and cervical cancer. Although the virus is highly prevalent, only a small number of women have a persistent HPV infection and subsequently develop clinically significant disease...
November 1, 2016: Microbiome
https://www.readbyqxmd.com/read/27799747/reaching-women-in-the-peruvian-andes-through-cervical-cancer-screening-campaigns-assessing-attitudes-of-stakeholders-and-patients
#5
John S Luque, Jonathan N Maupin, Daron G Ferris, Wendy S Guevara Condorhuaman
BACKGROUND: Peru is characterized by high cervical cancer incidence and mortality rates. The country also experiences significant gaps in quality cervical cancer screening coverage for the population. OBJECTIVE: This descriptive mixed methods study conducted in Cusco, Peru, aimed to assess the attitudes and perceptions of medical staff, health care workers, and patients toward a cervical cancer screening program that included both clinic-based and community outreach services conducted by a nongovernmental organization clinic (CerviCusco)...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27788480/oral-human-papillomavirus-infection-sexual-behaviors-and-risk-of-oral-squamous-cell-carcinoma-in-southeast-of-china-a-case-control-study
#6
Fa Chen, Lingjun Yan, Fengqiong Liu, Jiangfeng Huang, Fangping Liu, Junfeng Wu, Yu Qiu, Xiaoyan Zheng, Lin Cai, Lisong Lin, Baochang He
BACKGROUND: The causal association between human papillomavirus (HPV) and oral squamous cell carcinoma (OSCC) remains controversial. Most of previous studies did not consider the potential modification effect of sexual behaviors when evaluating the role of HPV infection in OSCC risk. OBJECTIVES: To explore the independent and joint effects of oral HPV infection and sexual behaviors on OSCC in Chinese population. STUDY DESIGN: A case-control study was conducted from September 2012 to September 2015 in Fujian, China...
October 22, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27764154/a-low-cost-hpv-immunochromatographic-assay-to-detect-high-grade-cervical-intraepithelial-neoplasia
#7
Vânia Sammartino Mariano, Adriana Tarlá Lorenzi, Cristovam Scapulatempo-Neto, Maíra Degiovani Stein, Julio Cesar Possati Resende, Márcio Antoniazzi, Luisa Lina Villa, José Eduardo Levi, Adhemar Longatto-Filho, José Humberto Tavares Guerreiro Fregnani
OBJECTIVE: To evaluate the reproducibility and accuracy of the HPV16/18-E6 test. METHODS: The study population was comprised of 448 women with a previously abnormal Pap who were referred to the Barretos Cancer Hospital (Brazil) for diagnosis and treatment. Two cervical samples were collected immediately before colposcopy, one for the hr-HPV-DNA test and cytology and the other for the HPV16/18-E6 test using high-affinity monoclonal antibodies (mAb). Women with a histologic diagnosis of cervical intraepithelial neoplasia grade 2 or 3 were considered to be positive cases...
2016: PloS One
https://www.readbyqxmd.com/read/27718061/society-of-behavioral-medicine-supports-increasing-hpv-vaccination-uptake-an-urgent-opportunity-for-cancer-prevention
#8
Caryn E Peterson, J Andrew Dykens, Noel T Brewer, Joanna Buscemi, Karriem Watson, DeLawnia Comer-Hagans, Zo Ramamonjiarivelo, Marian Fitzgibbon
Human papillomavirus (HPV) vaccine coverage remains low in the USA. The Society for Behavioral Medicine (SBM) supports the goals outlined by Healthy People 2020, the President's Cancer Panel, and the National Vaccine Advisory Committee to increase vaccination coverage among both males and females. SBM makes the following recommendations in support of efforts to reduce structural and other barriers to HPV vaccination services in order to increase rates of series completion. We encourage legislators and other policymakers to improve administration authority, insurance coverage, and reimbursement rates to healthcare providers who make the HPV vaccine available to adolescents; provide instrumental support to fund the development of school curricula on HPV vaccination; and increase public awareness that HPV vaccination can prevent cancer...
December 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27717385/l1-and-l2-gene-polymorphisms-in-hpv-58-and-hpv-33-implications-for-vaccine-design-and-diagnosis
#9
Zuyi Chen, Yaling Jing, Qiang Wen, Xianping Ding, Shun Zhang, Tao Wang, Yiwen Zhang, Jianhui Zhang
BACKGROUND: Cervical cancer is associated with infection by certain subtypes of human papillomavirus (HPV). The L1 protein comprising HPV vaccine formulations elicits high-titre neutralizing antibodies and confers protection against specific HPV subtypes. HPV L2 protein is an attractive candidate for cross-protective vaccines. HPV-33 and HPV-58 are very prevalent among Chinese women. METHODS: To study the gene intratypic variations and polymorphisms of HPV-33 and HPV-58 L1/L2 in Sichuan China, HPV-33 and HPV-58 L1 and L2 genes were sequenced and compared with other genes submitted to GenBank...
October 7, 2016: Virology Journal
https://www.readbyqxmd.com/read/27687213/facilitators-and-barriers-to-the-use-of-standing-orders-for-vaccination-in-obstetrics-and-gynecology-settings
#10
Juliana G Barnard, Amanda F Dempsey, Sarah E Brewer, Jennifer Pyrzanowski, Sara E Mazzoni, Sean T O'Leary
BACKGROUND: Many young and middle-aged women receive their primary health care from their obstetrician-gynecologists. A recent change to vaccination recommendations during pregnancy has forced the integration of new clinical processes at obstetrician-gynecology practices. Evidence-based best practices for vaccination delivery include the establishment of vaccination standing orders. OBJECTIVES: As part of an intervention to increase adoption of evidence-based vaccination strategies for women in safety-net and private obstetrician-gynecology settings, we conducted a qualitative study to identify the facilitators and barriers experienced by obstetrician-gynecology sites when establishing vaccination standing orders...
September 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27683269/identification-of-genetic-variation-in-the-lncrna-hotair-associated-with-hpv16-related-cervical-cancer-pathogenesis
#11
Sweta Sharma Saha, Rahul Roy Chowdhury, Nidhu Ranjan Mondal, Biman Chakravarty, Tanmay Chatterjee, Sudipta Roy, Sharmila Sengupta
PURPOSE: Previously, over-expression of the long noncoding RNA (lncRNA) HOTAIR has been found to be associated with the invasive and metastatic capacities of several epithelial cancers, including cervical cancer (CaCx). Here, we aimed at identifying functionally relevant genetic variants that may be employed to differentiate between clinically distinct CaCx subtypes, i.e., those exhibiting high HOTAIR levels and molecular signatures of metastasis and those lacking such signatures in the presence of low HOTAIR expression levels...
September 28, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27650602/guidance-on-liquid-based-cytology-system-conversion-training-a-secondary-publication
#12
A Wilson
National cervical screening programmes are considering a move to HPV primary screening. HPV testing requires the cervical sample to be placed in liquid based cytology (LBC) media and the triage cytology test will be carried out using LBC preparations. The resources required for conversion training from conventional smears to LBC should not be underestimated as errors can be made without the use of a structured training plan and monitoring of performance. In the UK, many labs have converted between the two main LBC technologies, Thinprep and Surepath...
October 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27647088/the-impact-of-socio-economic-determinants-on-the-vaccination-rates-with-rotavirus-and-human-papiloma-virus-vaccine
#13
Urška Grdadolnik, Maja Sočan
BACKGROUND: Socio-economic inequalities may have an impact on the uptake of selfpaid vaccines. The aim of the study was to identify the effect of some socio economic determinants on vaccination rates with self-paid human papilloma virus (HPV) and rotavirus (RV) vaccines. METHODS: Vaccination coverage data, available in electronic database cepljenje.net (administered by the National Institute of Public Health), were collected at administrative unit level. The socio-economic determinants (the average gross pay in euros, the unemployment rate, the educational and households structure, the population density, the number of inhabitants, the number of children aged from 0 to 4, the number of women aged from 15 to 30) were extracted from Statistical Office of the Republic of Slovenia web page...
March 2016: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/27640203/clinician-and-parent-perspectives-on-educational-needs-for-increasing-adolescent-hpv-vaccination
#14
Christy A Widman, Elisa M Rodriguez, Frances Saad-Harfouche, Annamaria Masucci Twarozek, Deborah O Erwin, Martin C Mahoney
Human papillomavirus (HPV)-related morbidity and mortality remain a significant public health burden despite the availability of HPV vaccines for cancer prevention. We engaged clinicians and parents to identify barriers and opportunities related to adolescent HPV vaccination within a focused geographic region. This mixed-method study design used an interviewer-administered semi-structured interview with clinicians (n = 52) and a written self-administered survey with similar items completed by parents (n = 54)...
September 17, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27636103/common-fragile-sites-cfs-and-extremely-large-cfs-genes-are-targets-for-human-papillomavirus-integrations-and-chromosome-rearrangements-in-oropharyngeal-squamous-cell-carcinoma
#15
Ge Gao, Sarah H Johnson, George Vasmatzis, Christina E Pauley, Nicole M Tombers, Jan L Kasperbauer, David I Smith
Common fragile sites (CFS) are chromosome regions that are prone to form gaps or breaks in response to DNA replication stress. They are often found as hotspots for sister chromatid exchanges, deletions, and amplifications in different cancers. Many of the CFS regions are found to span genes whose genomic sequence is greater than 1 Mb, some of which have been demonstrated to function as important tumor suppressors. CFS regions are also hotspots for human papillomavirus (HPV) integrations in cervical cancer. We used mate-pair sequencing to examine HPV integration events and chromosomal structural variations in 34 oropharyngeal squamous cell carcinoma (OPSCC)...
January 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27612993/quantifying-the-benefits-of-using-read-across-and-in-silico-techniques-to-fulfill-hazard-data-requirements-for-chemical-categories
#16
Kathleen Stanton, Francis H Kruszewski
Substantial benefits are realized through the use of read-across and in silico techniques to fill data gaps for structurally similar substances. Considerable experience in applying these techniques was gained under two voluntary high production volume (HPV) chemical programs - the International Council of Chemical Associations' (ICCA) Cooperative Chemicals Assessment Programme (with the cooperation of the Organization of Economic Cooperation and Development) and the U.S. Environmental Protection Agency's HPV Challenge Program...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27611218/aquatic-toxicity-structure-activity-relationships-for-the-zwitterionic-surfactant-alkyl-dimethyl-amine-oxide-to-several-aquatic-species-and-a-resulting-species-sensitivity-distribution
#17
Scott E Belanger, Jessica L Brill, Jane M Rawlings, Kathleen M McDonough, Ann C Zoller, Kenneth R Wehmeyer
Amine oxide (AO) is a cationically charged surfactant at environmental pH and has previously been assessed in the OECD (Organization for Economic Cooperation and Development) High Production Volume (HPV) chemicals program. Typical of cationic chemicals, AO is highly aquatically toxic. In this study we vastly improve the knowledge of AO toxicity by developing acute Quantitative Structure Activity Relationships (QSARs) for an alga (Desmodesmus subspicatus), an invertebrate (Daphnia magna) and a fish (Danio rerio) using the appropriate array of OECD Test Guidelines...
September 6, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27608036/analysis-of-the-prevalence-of-htlv-1-proviral-dna-in-cervical-smears-and-carcinomas-from-hiv-positive-and-negative-kenyan-women
#18
Xiaotong He, Innocent O Maranga, Anthony W Oliver, Peter Gichangi, Lynne Hampson, Ian N Hampson
The oncogenic retrovirus human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in some countries although its prevalence and relationship with other sexually transmitted infections in Sub-Saharan Africa is largely unknown. A novel endpoint PCR method was used to analyse the prevalence of HTLV-1 proviral DNA in genomic DNA extracted from liquid based cytology (LBC) cervical smears and invasive cervical carcinomas (ICCs) obtained from human immunodeficiency virus-positive (HIV+ve) and HIV-negative (HIV-ve) Kenyan women...
2016: Viruses
https://www.readbyqxmd.com/read/27585033/as-through-a-glass-darkly-the-future-of-sexually-transmissible-infections-among-gay-bisexual-and-other-men-who-have-sex-with-men
#19
Mark Richard Stenger, Stefan Baral, Shauna Stahlman, Dan Wohlfeiler, Jerusha E Barton, Thomas Peterman
The trajectory of sexually transmissible infection (STI) incidence among gay and other men who have sex with men (MSM) suggests that incidence will likely remain high in the near future. STIs were hyperendemic globally among MSM in the decades preceding the HIV epidemic. Significant changes among MSM as a response to the HIV epidemic, caused STI incidence to decline, reaching historical nadirs in the mid-1990s. With the advent of antiretroviral treatment (ART), HIV-related mortality and morbidity declined significantly in that decade...
September 2, 2016: Sexual Health
https://www.readbyqxmd.com/read/27577734/-screening-for-cervical-and-breast-cancer
#20
J Wilm, S Schüler-Toprak, O Ortmann
Screening programs for cervical cancer and breast cancer lead to a clear reduction of mortality. Starting in 2018 screening for cervical cancer will be structured as an organized program as already exists for breast cancer. In future screening for cervical cancer will be primarily performed by human papillomavirus (HPV) testing at intervals of 5 years while cytological examination (Pap smear) will also be available as an additional or alternative procedure. For breast cancer screening in Germany an annual clinical examination with palpation and mammography screening at 2‑year intervals is provided for women aged between 50 and 69 years...
September 2016: Der Pathologe
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