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HPV structure

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https://www.readbyqxmd.com/read/28388355/in-silico-analysis-of-l1-l2-sequences-of-human-papillomaviruses-implication-for-universal-vaccine-design
#1
Nazila Ghorban Hosseini, Majid Tebianian, Ayoub Farhadi, Ali Hossein Khani, Arian Rahimi, Mojtaba Mortazavi, Seyed Younes Hosseini, Morteza Taghizadeh, Mahsa Rezaei, Mehdi Mahdavi
The aim of this study was to design a multiepitope universal vaccine for major human papillomavirus (HPV) structural proteins, L1/L2, by bioinformatics models. For this purpose, we predicted the most probable immunogenic epitopes of L1 and L2 from common high-risk HPV 16, 18, 31, and 45 beside high prevalent type 6 and 11 based on BCPREDS defaulted model, while solvent accessibility of structure was extrapolated. The three-dimensional molecular model of L1 protein was constructed by Swiss Model server, whereas sequence alignment provided model for prediction of L2 protein epitopes...
April 2017: Viral Immunology
https://www.readbyqxmd.com/read/28341458/not-just-a-woman-s-business-understanding-men-and-women-s-knowledge-of-hpv-the-hpv-vaccine-and-hpv-associated-cancers
#2
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Kahee A Mohammed, Betelihem B Tobo, Christian J Geneus, Mario Schootman
Few studies have included men when assessing differences in knowledge about HPV, and HPV-associated cancers. We examined gender differences in knowledge about HPV, HPV vaccine, and HPV-associated cancers. Multivariable logistic regression models were used to analyze data of 3,677 survey respondents aged 18 years and older from the 2014 Health Information National Trends Survey. Covariates included age, race/ethnicity, marital status, education, income level, regular provider, general health, internet use, and family structure aged 9 to 27 years...
March 22, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28291647/health-professional-feedback-on-hpv-vaccination-roll-out-in-a-developing-country
#3
Collette Venturas, Kanayo Umeh
BACKGROUND: Worldwide, Zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). The human papilloma virus (HPV) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-Saharan countries, such as Zambia. Past research suggests health professionals' experiences with HPV vaccination rollout can have practical implications for effective delivery. OBJECTIVE: To explore health professionals' perspectives on the HPV vaccination programme in Zambia...
March 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28288596/needles-jabs-and-jags-a-qualitative-exploration-of-barriers-and-facilitators-to-child-and-adult-immunisation-uptake-among-gypsies-travellers-and-roma
#4
Cath Jackson, Helen Bedford, Francine M Cheater, Louise Condon, Carol Emslie, Lana Ireland, Philippa Kemsley, Susan Kerr, Helen J Lewis, Julie Mytton, Karen Overend, Sarah Redsell, Zoe Richardson, Christine Shepherd, Lesley Smith, Lisa Dyson
BACKGROUND: Gypsies, Travellers and Roma (referred to as Travellers) are less likely to access health services including immunisation. To improve immunisation rates, it is necessary to understand what helps and hinders individuals in these communities in taking up immunisations. This study had two aims. 1. Investigate the views of Travellers in the UK on the barriers and facilitators to acceptability and uptake of immunisations and explore their ideas for improving immunisation uptake; 2...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28270859/genetic-variability-in-e6-e7-and-l1-genes-of-human-papillomavirus-62-and-its-prevalence-in-mexico
#5
Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy
BACKGROUND: Human papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV genotypes is associated with premalignant lesions and cervical cancer development. HPVs considered as low risk or not yet classified, are often found in coinfection with different HPV genotypes. Indeed, HPV62 is one of the most prevalent HPV detected in some countries, but there is limited information about its prevalence in other regions and there are no HPV62 variants currently described...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28267627/stop-codon-mutagenesis-for-homogenous-expression-of-human-papillomavirus-l1-protein-in-escherichia-coli
#6
Daning Wang, Fei Fan, Zhihai Li, Xinlin Liu, Shuo Song, Shuangping Wei, Maozhou He, Yahua Lin, Zhongyi Li, Minxi Wei, Hai Yu, Ying Gu, Shaowei Li, Ningshao Xia
Human papillomavirus (HPV) is widely accepted to be the major causative pathogen of cervical cancer, warts, and other epithelial tumors. Virus infection and subsequent disease development can be prevented by vaccination with HPV vaccines derived from eukaryotic expression systems. Here, we report the soluble expression of the major capsid protein L1 of HPV31, a dominant carcinogenic HPV genotype, in Escherichia coli. HPV31 L1 protein and its elongated form (L1+) were observed in SDS-PAGE and CE-SDS analysis, generated by the native HPV31 L1 gene with a TAA stop codon...
March 4, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28225785/betel-nut-chewing-oral-premalignant-lesions-and-the-oral-microbiome
#7
Brenda Y Hernandez, Xuemei Zhu, Marc T Goodman, Robert Gatewood, Paul Mendiola, Katrina Quinata, Yvette C Paulino
Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Study participants were recruited from a dental clinic in Guam. Structured interviews and oral examinations were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28209524/foxa1-in-hpv-associated-carcinomas-its-expression-in-carcinomas-of-the-head-and-neck-and-of-the-uterine-cervix
#8
Georgia Karpathiou, Vanessa Da Cruz, Francois Casteillo, Mousa Mobarki, Jean Marc Dumollard, Celine Chauleur, Fabien Forest, Jean Michel Prades, Michel Peoc'h
BACKGROUND: FOXA1 is a major transcription factor involved in the action of human papilloma virus (HPV). However, it has been never studied in HPV-associated tumors. AIM OF THE STUDY: To investigate its expression in cervical and head and neck tumors. MATERIAL AND METHODS: 63 cervical carcinomas/dysplasias and 152 head and neck squamous cell carcinomas (HNSCC) were immunohistochemically studied for the expression of FOXA1. RESULTS: 63...
February 14, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28187495/differential-hpv16-variant-distribution-in-squamous-cell-carcinoma-adenocarcinoma-and-adenosquamous-cell-carcinoma
#9
S Nicolás-Párraga, L Alemany, S de Sanjosé, F X Bosch, I G Bravo
Human Papillomavirus 16 (HPV16) causes 70% of invasive cervical cancers (ICC) worldwide. Interaction between HPV16 genetic diversity, host genetics and target tissue largely determine the chances to trigger carcinogenesis. We have analyzed the differential prevalence of viral variants in 233 HPV16-monoinfected squamous (SCC), glandular (ADC) and mixed (ADSC) ICCs from four continents, assessing the contribution of geographical origin and cancer histology. We have further quantified the contribution of viral variants and cancer histology to differences in age at tumor diagnosis...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28178455/seeing-hpv-in-the-new-light-offers-a-glimpse-of-heparin
#10
Peter C Angeletti
In this issue of Structure, Guan et al. (2017) describe cryo-EM mapping of human papillomavirus 16 (HPV16) capsids that propose locations for L2 and heparin binding sites. The high resolution of the modern cryo-EM methods (in this case down to 4.3 Å) opens great opportunities to probe conformational changes that take place during virus-receptor binding.
February 7, 2017: Structure
https://www.readbyqxmd.com/read/28176847/marine-streptomyces-sp-derived-antimycin-analogues-suppress-hela-cells-via-depletion-hpv-e6-e7-mediated-by-ros-dependent-ubiquitin-proteasome-system
#11
Weiyi Zhang, Qian Che, Hongsheng Tan, Xin Qi, Jing Li, Dehai Li, Qianqun Gu, Tianjiao Zhu, Ming Liu
Four new antimycin alkaloids (1-4) and six related known analogs (5-10) were isolated from the culture of a marine derived Streptomyces sp. THS-55, and their structures were elucidated by extensive spectroscopic analysis. All of the compounds exhibited potent cytotoxicity in vitro against HPV-transformed HeLa cell line. Among them, compounds 6-7 were derived as natural products for the first time, and compound 5 (NADA) showed the highest potency. NADA inhibited the proliferation, arrested cell cycle distribution, and triggered apoptosis in HeLa cancer cells...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28141822/e6-and-e7-gene-polymorphisms-in-human-papillomavirus-types-58-and-33-identified-in-southwest-china
#12
Zuyi Chen, Yaling Jing, Qiang Wen, Xianping Ding, Tao Wang, Xuemei Mu, Yuwei Chenzhang, Man Cao
Cancer of the cervix is associated with infection by certain types of human papillomavirus (HPV). The gene variants differ in immune responses and oncogenic potential. The E6 and E7 proteins encoded by high-risk HPV play a key role in cellular transformation. HPV-33 and HPV-58 types are highly prevalent among Chinese women. To study the gene intratypic variations, polymorphisms and positive selections of HPV-33 and HPV-58 E6/E7 in southwest China, HPV-33 (E6, E7: n = 216) and HPV-58 (E6, E7: n = 405) E6 and E7 genes were sequenced and compared to others submitted to GenBank...
2017: PloS One
https://www.readbyqxmd.com/read/28120845/association-of-hpv-infection-and-clearance-with-cervicovaginal-immunology-and-the-vaginal-microbiota
#13
B Shannon, T J Yi, S Perusini, P Gajer, B Ma, M S Humphrys, J Thomas-Pavanel, L Chieza, P Janakiram, M Saunders, W Tharao, S Huibner, K Shahabi, J Ravel, A Rebbapragada, R Kaul
Cervical human papillomavirus (HPV) infection may increase HIV risk. Since other genital infections enhance HIV susceptibility by inducing inflammation, we assessed the impact of HPV infection and clearance on genital immunology and the cervico-vaginal microbiome. Genital samples were collected from 65 women for HPV testing, immune studies and microbiota assessment; repeat HPV testing was performed after 6 months. All participants were HIV-uninfected and free of bacterial STIs. Cytobrush-derived T cell and dendritic cell subsets were assessed by multiparameter flow cytometry...
January 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28114406/identification-of-hpv-types-and-mycobacterium-tuberculosis-complex-in-historical-long-term-preserved-formalin-fixed-tissues-in-different-human-organs
#14
Maja Hühns, Andreas Erbersdobler, Annette Obliers, Paula Röpenack
University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis...
2017: PloS One
https://www.readbyqxmd.com/read/28112728/integrated-genomic-and-molecular-characterization-of-cervical-cancer
#15
(no author information available yet)
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib...
March 16, 2017: Nature
https://www.readbyqxmd.com/read/28100386/-effect-of-extracellular-signal-regulated-kinas-1-2-expression-and-hpv16-infection-and-their-interaction-in-progression-of-cervical-cancerization
#16
S L Fan, L Ding, Z Y Ren, X Chen, X S Sun, C C Li, C L Liu, W L Jia, Q L Li, J T Wang
Objective: To investigate the effect of ERK1/2 protein expression and HPV16 infection, as well as their interaction in the cervical carcinogenesis. Methods: A total of 176 patients, including 34 cases with normal cervix (NC), 26 cases with cervical intraepithelial neoplasm Ⅰ (CIN Ⅰ), 57 cases with cervical intraepithelial neoplasm Ⅱ/Ⅲ (CIN Ⅱ/Ⅲ) and 59 cases with cervical squamous cell carcinoma (SCC), were enrolled from Shanxi Tumor Hospital, Shanxi Maternal and Child Health Center, Jincheng Coal General Hospital from September 2013 to March 2014...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28098865/endophytic-fungi-from-mangrove-inhibit-lung-cancer-cell-growth-and-angiogenesis-in-vitro
#17
Xin Liu, Xin Wu, Yuefan Ma, Wenzhang Zhang, Liang Hu, Xiaowei Feng, Xiangyong Li, Xudong Tang
The secondary metabolites of mangrove-derived endophytic fungi contain multiple substances with novel structures and biological activities. In the present study, three types of mangrove plants, namely Kandelia candel, Rhizophora stylosa and Rhizophoraceae from Zhanjiang region including the leaves, roots and stems were collected, and endophytic fungi were isolated, purified and identified from these mangrove plants. MTT assay was used to observe the effects of the isolated endophytic fungi on the growth of A549 and NCI-H460 lung cancer cells...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28086983/mailed-hpv-self-sampling-for-cervical-cancer-screening-among-underserved-minority-women-study-protocol-for-a-randomized-controlled-trial
#18
Erin Kobetz, Julia Seay, Anthony Amofah, Larry Pierre, Jordan Baeker Bispo, Dinah Trevil, Martha Gonzalez, Martine Poitevien, Tulay Koru-Sengul, Olveen Carrasquillo
BACKGROUND: Underserved ethnic minority women experience significant disparities in cervical cancer incidence and mortality, mainly due to lack of cervical cancer screening. Barriers to Pap smear screening include lack of knowledge, lack of health insurance and access, and cultural beliefs regarding disease prevention. In our previous SUCCESS trial, we demonstrated that HPV self-sampling delivered by a community health worker (CHW) is efficacious in circumventing these barriers. This approach increased screening uptake relative to navigation to Pap smear screening...
January 13, 2017: Trials
https://www.readbyqxmd.com/read/28065506/cryoelectron-microscopy-maps-of-human-papillomavirus-16-reveal-l2-densities-and-heparin-binding-site
#19
Jian Guan, Stephanie M Bywaters, Sarah A Brendle, Robert E Ashley, Alexander M Makhov, James F Conway, Neil D Christensen, Susan Hafenstein
Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. The current commercial vaccines are genotype specific and provide little therapeutic benefit to patients with existing HPV infections. Host entry mechanisms represent an excellent target for alternative therapeutics, but HPV receptor use, the details of cell attachment, and host entry are inadequately understood. Here we present near-atomic resolution structures of the HPV16 capsid and HPV16 in complex with heparin, both determined from cryoelectron micrographs collected with direct electron detection technology...
February 7, 2017: Structure
https://www.readbyqxmd.com/read/28061478/mitotic-control-of-human-papillomavirus-genome-containing-cells-is-regulated-by-the-function-of-the-pdz-binding-motif-of-the-e6-oncoprotein
#20
Elizabeth K Marsh, Craig P Delury, Nicholas J Davies, Christopher J Weston, Mohammed A L Miah, Lawrence Banks, Joanna L Parish, Martin R Higgs, Sally Roberts
The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types contributes to the development of HPV-associated malignancies. Here, using a primary human keratinocyte-based model of the high-risk HPV18 life cycle, we identify a novel link between the E6 PBM and mitotic stability. In cultures containing a mutant genome in which the E6 PBM was deleted there was an increase in the frequency of abnormal mitoses, including multinucleation, compared to cells harboring the wild type HPV18 genome...
March 21, 2017: Oncotarget
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