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https://www.readbyqxmd.com/read/28814070/hpv-genotype-specific-persistence-and-potential-risk-factors-among-korean-women-results-from-a-2-year-follow-up-study
#1
Cecile Ingabire, Min Kyung Lim, Young-Joo Won, Jin-Kyoung Oh
Purpose: High-risk human papilloma virus (HPV) infection progression should be considered a critical factor for preventing cervical cancer, although most infections are transient and rarely persist. This study aimed to examine the specific types of HPV infections, their change patterns, and the potential risk factors among Korean women. Materials and Methods: We included 4,588 women who visited hospitals in Busan and Suwon for cervical cancer screening, and 1,224 of these women attended a 2-year follow-up...
August 17, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28812825/evaluating-global-health-partnerships-a-case-study-of-a-gavi-hpv-vaccine-application-process-in-uganda
#2
Carol Kamya, Jessica Shearer, Gilbert Asiimwe, Emily Carnahan, Nicole Salisbury, Peter Waiswa, Jennifer Brinkerhoff, Dai Hozumi
BACKGROUND: Global health partnerships have grown rapidly in number and scope, yet there has been less emphasis on their evaluation. Gavi, the Vaccine Alliance, is one such public-private partnership; in Gavi-eligible countries partnerships are dynamic networks of immunization actors who work together to support all stages and aspects of Gavi support. This paper describes a conceptual framework - the partnership framework - and analytic approach for evaluating the perceptions of partnerships' added value as well as the results from an application to one case in Uganda...
October 26, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28797293/health-care-providers-perceptions-of-use-and-influence-of-clinical-decision-support-reminders-qualitative-study-following-a-randomized-trial-to-improve-hpv-vaccination-rates
#3
Brian E Dixon, Monica L Kasting, Shannon Wilson, Amit Kulkarni, Gregory D Zimet, Stephen M Downs
BACKGROUND: Human Papillomavirus (HPV) leads to serious health issues and remains the most common sexually transmitted infection. Despite availability of effective vaccines, HPV vaccination rates are suboptimal. Furthermore, providers recommend the HPV vaccine less than half the time for eligible patients. Prior informatics research has demonstrated the effectiveness of computer-based clinical decision support (CDS) in changing provider behavior, especially in the area of preventative services...
August 10, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28796684/maternal-and-infant-outcomes-after-human-papillomavirus-vaccination-in-the-periconceptional-period-or-during-pregnancy
#4
Heather S Lipkind, Gabriela Vazquez-Benitez, James D Nordin, Paul A Romitti, Allison L Naleway, Nicola P Klein, Rulin C Hechter, Michael L Jackson, Simon J Hambidge, Grace M Lee, Lakshmi Sukumaran, Elyse O Kharbanda
OBJECTIVE: To evaluate whether quadrivalent human papillomavirus (HPV) vaccine administered during the periconceptional period or during pregnancy was associated with increased risks for adverse obstetric events, adverse birth outcomes, or selected major structural birth defects. METHODS: We conducted a retrospective, observational cohort study using administrative and health care data from the Vaccine Safety Datalink. Insured women 13-27 years old with singleton pregnancies and a live birth from January 1, 2007, through September 1, 2013, who received quadrivalent HPV vaccine during the periconceptional period (2 weeks before to 2 weeks after their last menstrual period), during pregnancy, or during both periods combined were compared with women who had a live birth during the same time period and received quadrivalent HPV vaccine 4-18 months before their last menstrual period...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28780192/a-novel-hpv-prophylactic-peptide-vaccine-designed-by-immunoinformatics-and-structural-vaccinology-approaches
#5
Manica Negahdaripour, Mahboobeh Eslami, Navid Nezafat, Nasim Hajighahramani, Mohammad Bagher Ghoshoon, Eskandar Shoolian, Ali Dehshahri, Nasrollah Erfani, Mohammad Hossein Morowvat, Younes Ghasemi
Human papillomavirus (HPV)-caused cervical cancer is the fourth common female cancer globally. Despite availability of three effective vaccines in market, development of HPV prophylactic vaccines is still pursued due to affordability issues and type-restricted protection of the marketed vaccines. Investigational second generation prophylactic HPV vaccines are mostly exploiting epitopes from the virus minor capsid protein (L2), which despite many advantages suffer from low immunogenicity, a common problem of epitope vaccines...
August 2, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28766319/acceptability-of-school-based-health-centers-for-human-papillomavirus-vaccination-visits-a-mixed-methods-study
#6
Caitlin E Hansen, Edirin Okoloko, Adedotun Ogunbajo, Anna North, Linda M Niccolai
BACKGROUND: Countries with high human papillomavirus (HPV) vaccination rates have achieved this success largely through school-based vaccination. Using school-based health centers (SBHCs) in the United States, where HPV vaccine remains underutilized, could improve uptake. In this mixed-methods study, we examined acceptability, facilitators, and barriers of HPV vaccination visits at SBHCs from the perspectives of adolescents and parents. METHODS: We conducted qualitative interviews and structured surveys with adolescents and parents recruited from an urban, hospital-based clinic...
September 2017: Journal of School Health
https://www.readbyqxmd.com/read/28750068/using-actor-partner-interdependence-modeling-to-understand-hpv-vaccine-acceptance
#7
Laura E VanderDrift, Peter A Vanable, Katherine E Bonafide, Jennifer L Brown, Rebecca A Bostwick, Michael P Carey
A wealth of scientific literature has been devoted to understanding what factors influence parents and their adolescent children to obtain the HPV vaccine. This literature is relatively uniform in its methodological approach of sampling individuals (i.e., either parents or adolescents) and examining the predictors of uptake for that individual. To improve understanding of HPV vaccination uptake, we sampled low-income, African American parent-child dyads with either a female (n = 93) or a male (n = 116) adolescent who had not been vaccinated...
2017: PloS One
https://www.readbyqxmd.com/read/28742991/sexual-inactivity-and-occurrence-of-stis-in-relation-to-weight-status-in-women-two-large-population-based-studies
#8
Vibeke B Gunge, Kirsten E Juul, Adriaan Jc van den Brule, Thomas Iftner, Susanne K Kjær
The aim of this study was to examine sexual inactivity and occurrence of selected sexually transmitted infections in relation to body mass index. We used data from two large Danish population-based cross-sectional studies conducted in 1991-1995 (HPV-study: 6869 women, aged 22-32 years) and in 2004-2005 (Liva-study: 19,484 women, aged 18-45 years). Data were collected using a structured interview and measured weight, height, high-risk human papillomavirus DNA, Chlamydia DNA for the HPV-study and a structured questionnaire for the Liva-study...
July 25, 2017: Women & Health
https://www.readbyqxmd.com/read/28736202/primary-care-team-and-clinic-level-factors-affecting-hpv-vaccine-uptake
#9
Emmeline Chuang, Claudia Cabrera, Selene Mak, Beth Glenn, Michael Hochman, Roshan Bastani
OBJECTIVE: This study examined patient-, care team- and clinic-level factors associated with human papillomavirus (HPV) vaccine initiation and completion. METHODS: HPV vaccine initiation and completion rates among adolescents aged 9-18years were assessed using administrative data (n=38,277) from a large federally qualified health center serving predominantly Latino patients. Four clinics with particularly high and low adolescent HPV vaccine uptake were selected for in-depth case study analyses...
July 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28733985/lalf32-51-e7-a-hpv-16-therapeutic-vaccine-candidate-forms-protein-body-like-structures-when-expressed-in-nicotiana-benthamiana-leaves
#10
Romana J R Yanez, Renate Lamprecht, Milaid Granadillo, Isis Torrens, Elsa Arcalís, Eva Stöger, Edward P Rybicki, Inga I Hitzeroth
High-risk Human papillomaviruses (HPVs) cause cervical cancer, and while there are good prophylactic vaccines on the market, these are ineffective against established infections, creating a clear need for therapeutic vaccines. The HPV E7 protein is one of the essential oncoproteins for the onset and maintenance of malignancy, and is therefore an ideal therapeutic vaccine target. We fused the HPV-16 E7 protein to the Limulus polyphemus anti-lipopolysaccharide factor (LALF32-51 ), a small hydrophobic peptide that can penetrate cell membranes and that has immunomodulatory properties...
July 22, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28716790/human-papillomavirus-prevalence-and-genotype-distribution-among-young-women-and-men-in-maputo-city-mozambique
#11
Viegas Edna Omar, Augusto Orvalho, Ismael Nália, Kaliff Malin, Lillsunde-Larsson Gabriella, Ramqvist Torbjörn, Nilsson Charlotta, Falk Kerstin, Osman Nafissa, Jani Ilesh Vindorai, Andersson Sören
OBJECTIVES: Human papillomavirus (HPV) is a well-known cause of cervical cancer, the second most frequent cancer in female African populations. This study aimed at determining the prevalence of HPV infections and the genotype distribution in young adults aged 18-24, in Maputo city, Mozambique, and to assess the suitability of commercially available HPV vaccines. METHODS: This cross-sectional study was conducted between 2009 and 2011 at a youth clinic in Maputo Central Hospital...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28691664/impact-of-naturally-occurring-variation-in-the-human-papillomavirus-hpv-33-capsid-proteins-on-recognition-by-vaccine-induced-cross-neutralizing-antibodies
#12
Anna Godi, Sara L Bissett, Elizabeth Miller, Simon Beddows
We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus (HPV) genotype 33. Pseudoviruses (PsV) representing HPV33 lineages A1, A2, A3, B and C exhibited comparable particle-to-infectivity ratios and morphology but demonstrated a decreased sensitivity (A2, A3, B and C) to cross-neutralization by HPV vaccine antibodies compared to the A1 sublineage. Chimeric PsVs demonstrated that these differences in sensitivity were due to polymorphisms in the L1 protein, with little or no influence from variation within the L2 protein...
July 8, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28690376/linear-epitope-prediction-in-hpv-type-16-e7-antigen-and-their-docked-interaction-with-human-tmem-50a-structural-model
#13
Upasna Srivastava, Satendra Singh, Budhyash Gautam, Pramod Yadav, Madhu Yadav, George Thomas, Gurmit Singh
Human Papilloma Virus (HPV) HPV type 16 E7 antigen is a known target in cervical cancer. We report the predicted potential epitopes in the E7 antigen. We further describe the subsequent interaction of these linear epitope peptides with the human TMEM 50 A structural model using molecular docking. This data finds application in the development of components towards HPV associated disease prevention.
2017: Bioinformation
https://www.readbyqxmd.com/read/28652087/determinants-of-human-papillomavirus-vaccination-uptake-among-adolescent-girls-a-theory-based-longitudinal-study-among-hong-kong-chinese-parents
#14
Linda Dong-Ling Wang, Wendy Wing Tak Lam, Richard Fielding
Human papillomavirus (HPV) vaccination uptake among Chinese adolescent girls remains extremely low. This two-year longitudinal study examined theoretical predictors of adolescent girls' HPV vaccination uptake using an extended Theory of Planned Behaviour (TPB). Between February and November 2014, a random sample of 1996 (response rate 60%) Hong Kong Chinese parents of 12- to 17-year-old HPV unvaccinated girls completed baseline telephone interviews assessing attitudes and intention towards HPV vaccination. Six and 12months later 1255 and 979 parents reported their daughters' HPV vaccination status, respectively...
September 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28602548/impact-of-quadrivalent-human-papillomavirus-vaccine-on-genital-warts-in-an-opportunistic-vaccination-structure
#15
Samuel Lurie, Yossi Mizrachi, Gabi Chodick, Rachel Katz, Eduardo Schejter
OBJECTIVE: Genital warts are the most common sexually transmitted disease and have a detrimental impact on quality of life. Genital warts could be prevented by prophylactic HPV vaccination. The objective was to study real-life benefit of opportunistic HPV vaccination on age and gender specific incidence of genital warts. METHODS: We performed a register-based population cohort study from publicly funded health-care provider in Israel. The incidence of genital warts was assessed during three time frame intervals: 2006-2008 (pre-vaccination effect period) 2009-2012 (early post-vaccination effect period) and 2013-2015 (late post-vaccination effect period), with an average annual number of members of 1,765,481, 1,906,774 and 2,042,678 in the years 2006-2008, 2009-2012 and 2013-2015, respectively...
August 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28559012/establishment-and-characterization-of-an-oral-tongue-squamous-cell-carcinoma-cell-line-from-a-never-smoking-patient
#16
Steven J Wang, Saurabh Asthana, Annemieke van Zante, Chase M Heaton, Janyaporn Phuchareon, Leighton Stein, Saito Higuchi, Tomoya Kishimoto, Charles Y Chiu, Adam B Olshen, Frank McCormick, Osamu Tetsu
OBJECTIVE: The rising incidence of oral tongue squamous cell carcinoma (OTSCC) in patients who have never smoked and the paucity of knowledge of its biological behavior prompted us to develop a new cell line originating from a never-smoker. MATERIALS AND METHODS: Fresh tumor tissue of keratinizing OTSCC was collected from a 44-year-old woman who had never smoked. Serum-free media with a low calcium concentration were used in cell culture, and a multifaceted approach was taken to verify and characterize the cell line, designated UCSF-OT-1109...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28553758/hpv-vaccine-acceptance-among-african-american-mothers-and-their-daughters-an-inquiry-grounded-in-culture
#17
Kayoll V Galbraith-Gyan, Julia Lechuga, Coretta M Jenerette, Mary H Palmer, Angelo D Moore, Jill B Hamilton
BACKGROUND: Much of the research on African-Americans' HPV vaccine acceptance has largely focused on racial/ethnic differences related to cognitive, socio-economical, and structural factors that contribute to differences in HPV vaccine acceptance and completion. A growing body of literature suggest that cultural factors, such as mistrust of healthcare providers (HCPs) and the healthcare system, religion, and social norms related to appropriate sexual behaviors, also plays a prominent role in their HPV vaccine acceptance...
May 29, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28531277/genome-wide-discovery-of-viral-micrornas-based-on-phylogenetic-analysis-and-structural-evolution-of-various-human-papillomavirus-subtypes
#18
Shun-Long Weng, Kai-Yao Huang, Julia Tzu-Ya Weng, Fang-Yu Hung, Tzu-Hao Chang, Tzong-Yi Lee
In mammals, microRNAs (miRNAs) play key roles in controlling posttranscriptional regulation through binding to the mRNAs of target genes. Recently, it was discovered that viral miRNAs may be involved in human cancers and diseases. It is likely that viral miRNAs help viruses enter the latent phase of their life cycle and become undetected by the host's immune system, while increasing the host's risk for cancer development. Cervical cancer is typically related to the infection of human papillomavirus (HPV) through sexual transmission...
May 20, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28485691/adoption-of-the-hpv-vaccine-a-case-study-of-three-emerging-countries
#19
Araceli Caro Martínez, Jaime Espín Balbino, Alexandre Lemgruber, Eva Martín Ruiz, Antonio Olry de Labry Lima, Leticia García-Mochón, Fernanda Lessa
BACKGROUND: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample of central, eastern and southern Europe and Latin America and the Caribbean, all of them emerging in the use of HTA. MATERIALS & METHODS: A multi-country case study was designed...
May 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28485178/adoption-of-the-hpv-vaccine-a-case-study-of-three-emerging-countries
#20
Araceli Caro Martínez, Jaime Espín Balbino, Alexandre Lemgruber, Eva Martín Ruiz, Antonio Olry de Labry Lima, Leticia García Mochón, Fernanda Lessa
BACKGROUND: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample of central, eastern and southern Europe and Latin America and the Caribbean, all of them emerging in the use of HTA. MATERIALS & METHODS: A multi-country case study was designed...
May 9, 2017: Journal of Comparative Effectiveness Research
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