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HPV structure

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https://www.readbyqxmd.com/read/29458675/the-contribution-of-sp100-to-cottontail-rabbit-papillomavirus-transcription-and-replication
#1
M Wurdak, M Schneider, T Iftner, F Stubenrauch
SP100 proteins are components of nuclear domain 10 structures and have been implicated as inhibitors of human papillomavirus (HPV) replication. In this study, we have addressed the role of SP100 in tumour formation by the cottontail rabbit (Sylvilagus floridanus) papillomavirus (CRPV or SfPV1) in a rabbit model. Tissue culture studies using rabbit keratinocyte lines indicated that rabbit SP100 is an interferon-beta-inducible gene similar to its human counterpart. Stable knockdown of SP100 by shRNA in a cell line harbouring CRPV genomes resulted in a decrease of viral early transcripts...
January 24, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29449375/-novosphingobium-aromaticivorans-uses-a-nu-class-glutathione-s-transferase-as-a-glutathione-lyase-in-breaking-the-%C3%AE-aryl-ether-bond-of-lignin
#2
Wayne S Kontur, Craig A Bingman, Charles N Olmsted, Douglas R Wassarman, Arne Ulbrich, Daniel L Gall, Robert W Smith, Larissa M Yusko, Brian G Fox, Daniel R Noguera, Joshua J Coon, Timothy J Donohue
As a major component of plant cells walls, lignin is a potential renewable source of valuable chemicals. Several sphingomonad bacteria have been identified that can break the β-aryl ether bond connecting most phenylpropanoid units of the lignin heteropolymer. Here, we tested three sphingomonads predicted to be capable of breaking the β-aryl ether bond of the dimeric aromatic compound guaiacylglycerol-β-guaiacyl ether (GGE) and found that Novosphingobium aromaticivorans metabolizes GGE at one of the fastest rates thus far reported...
February 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29445898/knowledge-attitudes-and-barriers-to-human-papillomavirus-hpv-vaccine-uptake-among-an-immigrant-and-refugee-catch-up-group-in-a-western-canadian-province
#3
Erin McComb, Vivian Ramsden, Olufemi Olatunbosun, Hazel Williams-Roberts
Vaccination is a key strategy to prevent cervical cancer in developed countries. Lower uptake of human papillomavirus (HPV) vaccine among new immigrants and refugees has been documented, although exploration of underlying reasons remains an understudied area. Semi-structured interviews with eleven immigrant women (ages 18-26 years) were conducted to understand their knowledge, attitudes and barriers regarding HPV vaccination in a western Canadian province. Participants had limited knowledge about HPV and the vaccine...
February 14, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29436691/novel-structural-approaches-concerning-hpv-proteins-insight-into-targeted-therapies-for-cervical-cancer-review
#4
Kalliopi I Pappa, Georgia Kontostathi, Vasiliki Lygirou, Jerome Zoidakis, Nicholas P Anagnou
Cervical cancer incidence is tightly linked to HPV infection, and particularly virus types 16 and 18 cause the majority of cases presenting with pre-cancerous stages of cervical intraepithelial neoplasia (CIN). Structural and functional information concerning HPV proteins can offer novel insight into the mechanism(s) of cancer progression in the cervical epithelium. Recently, novel structural determinants of the interactions of viral proteins with their targets in keratinocytes have been elucidated. These exciting findings open the way for the development of targeted anti-oncogenic therapies, and may eventually allow the introduction of novel approaches for a rational cervical cancer treatment...
February 9, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29435841/radiation-therapy-for-the-head-and-neck-patient-advances-challenges-and-perspectives
#5
Sagus Sampath, Nayana Vora, Zachary Zumsteg
Radiation therapy for head and neck malignancies has made remarkable advances in treatment technology, resulting in improved clinical and functional outcomes. It is necessary for the radiation oncologist to have a complex understanding of the patient's tumor and its relationship to the surrounding normal anatomy, in order to safely limit dose to normal tissues. Complications following radiation can be managed with timely intervention, usually on an outpatient basis. This chapter will discuss the technological advances in the field, the impact of human papillomavirus (HPV)-mediated disease on radiation treatment, efforts to limit dose to critical salivary and swallowing structures, and management of certain radiation-related toxicities...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29366708/human-papillomavirus-vaccine-motivators-and-barriers-among-community-college-students-considerations-for-development-of-a-successful-vaccination-program
#6
Jacqueline M Hirth, Denise N Batuuka, Tyra T Gross, Leslie Cofie, Abbey B Berenson
BACKGROUND: Previous interventions in colleges to improve human papillomavirus (HPV) vaccination have not been highly successful. Although barriers have been assessed in traditional colleges, less is known about vaccination barriers in community colleges. METHODS: We approached students aged 18-26 years old enrolled at a community college for an in-person semi-structured qualitative interview on HPV vaccination and health, with questions guided by the Theory of Planned Behavior...
January 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29362118/late-radiation-associated-dysphagia-in-head-and-neck-cancer-patients-evidence-research-and-management
#7
REVIEW
F De Felice, M de Vincentiis, V Luzzi, G Magliulo, M Tombolini, G Ruoppolo, A Polimeni
In head and neck cancer (HNC) scenario, newer radiotherapy (RT) techniques, such as intensity modulated RT (IMRT), aim to reduce acute and late toxicity without impair tumor response and loco-regional control rates. However, late radiation-associated dysphagia (RAD) remains a major clinical problem and has gained a growing importance in the last few years, especially due to human papilloma virus (HPV)-related HNC favorable prognosis. The aim of this review was to provide clinical information about late RAD...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29360648/artificial-intelligence-estimates-the-impact-of-human-papillomavirus-types-in-influencing-the-risk-of-cervical-dysplasia-recurrence-progress-toward-a-more-personalized-approach
#8
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Chiara Borghi, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
The objective of this study was to determine whether the pretreatment human papillomavirus (HPV) genotype might predict the risk of cervical dysplasia persistence/recurrence. Retrospective analysis of prospectively collected data of consecutive 5104 women who underwent the HPV-DNA test were matched with retrospective data of women undergoing either follow-up or medical/surgical treatment(s) for genital HPV-related infection(s). Artificial neuronal network (ANN) analysis was used in order to weight the importance of different HPV genotypes in predicting cervical dysplasia persistence/recurrence...
January 22, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29353969/incidence-and-mortality-of-cervical-cancer-in-china-2013
#9
Bingbing Song, Chao Ding, Wangyang Chen, Huixin Sun, Maoxiang Zhang, Wanqing Chen
Objective: Estimating the incidence and mortality rate of cervical cancer became necessary to establish prevention measures and healthy policies. The aim of this study was to estimate the updated incidence and mortality rate of cervical cancer in 2013 in China. Methods: According to the evaluation criteria developed by the National Central Cancer Registry of China, the data submitted from 255 cancer registries met the required standards in 2013. Cervical cancer cases were retrieved from the national database and combined with the 2013 national population data...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29342959/structural-insights-in-multifunctional-papillomavirus-oncoproteins
#10
REVIEW
Irina Suarez, Gilles Trave
Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species...
January 15, 2018: Viruses
https://www.readbyqxmd.com/read/29341505/stability-integrity-and-recovery-rate-of-cellular-nucleic-acids-preserved-in-a-new-liquid-based-cytology-medium
#11
Guodong Zhao, Zhaocheng Liu, Yaping Tian, Minsheng Zhu, Shouli Wang, Hui Wang, Shen Gao, Yong Ma, Minxue Zheng
BACKGROUND: Liquid-based cytology (LBC) has replaced the conventional Papanicolaou test in cervical cancer screening. The cervical swab specimens collected in LBC media can also be used for additional analyses including high-risk HPV (HR-HPV) test, DNA methylation analysis, and HPV E6/E7 mRNA test. METHODS: The stability, integrity, and recovery rate of cellular DNA and RNA after storage at different conditions were evaluated by a quantitative real-time PCR (qPCR) based HR-HPV test, reverse transcription qPCR (RT-qPCR), and agarose gel electrophoresis...
January 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29338741/knowledge-and-practices-of-general-practitioners-at-district-hospitals-towards-cervical-cancer-prevention-in-burundi-2015-a-cross-sectional-study
#12
Zacharie Ndizeye, Davy Vanden Broeck, Heleen Vermandere, John Paul Bogers, Jean-Pierre Van Geertruyden
BACKGROUND: Well-organized screening and treatment programmes are effective to prevent Invasive Cervical Cancer (ICC) in LMICs. To achieve this, the World Health Organization (WHO) recommends the involvement of existing health personnel in casu doctors, nurses, midwives in ICC prevention. A necessary precondition is that health personnel have appropriate knowledge about ICC. Therefore, to inform policy makers and training institutions in Burundi, we documented the knowledge and practices of general practitioners (GPs) at district hospital level towards ICC control...
January 16, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29336272/let-7-mirna-precursors-co-express-with-lin28b-in-cervical-cells
#13
Alvarez-Salas, Zamora-Contreras
BACKGROUND: The let-7 microRNAs (miRNAs) are frequently dysregulated in carcinogenic processes, including cervical cancer. LIN28 proteins regulate let-7 biogenesis by binding to conserved sequences within the pre-miRNA structure. Nevertheless, recent research has shown that some let-7 miRNAs may escape LIN28 regulation. OBJECTIVE: Correlate pre-let-7 miRNAs and LIN28B levels in cervical cell lines with different malignancy and HPV content. METHODS: Pre-let-7 levels were determined by RTqPCR...
January 15, 2018: MicroRNA
https://www.readbyqxmd.com/read/29330033/service-quality-and-parents-willingness-to-get-adolescents-hpv-vaccine-from-pharmacists
#14
Parth D Shah, William A Calo, Macary W Marciniak, Carol E Golin, Betsy L Sleath, Noel T Brewer
We sought to examine whether pharmacy service quality was associated with parents' willingness to have immunizing pharmacists administer human papillomavirus (HPV) vaccine to their adolescent children. Participants were a national sample of 1504 US parents of adolescents ages 11 to 17 who completed an online survey in 2014. Analyses used structural equation modeling. Parents rated service quality and feelings of satisfaction with their pharmacies as moderate to high. Many (44%) were willing to get HPV vaccine from immunizing pharmacists for their adolescent children...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29325819/explanations-for-the-high-potency-of-hpv-prophylactic-vaccines
#15
John Schiller, Doug Lowy
HPV L1 virus-like particle (VLP) vaccines administered in a prime/boost series of three injections over six months have demonstrated remarkable prophylactic efficacy in clinical trials and effectiveness in national immunization programs with high rates of coverage. There is mounting evidence that the vaccines have similar efficacy and effectiveness even when administered in a single dose. The unexpected potency of one dose of these VLP vaccines may largely be attributed to structural features of the particles, which lead to the efficient generation of long-lived antigen-specific antibody-producing cells and unique features of the virus life cycle that make the HPV virions highly susceptible to antibody-mediated inhibition of infection...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29325530/knowledge-of-cervical-cancer-and-hpv-vaccine-in-bangladeshi-women-a-population-based-cross-sectional-study
#16
Jessica Yasmine Islam, Fatema Khatun, Anadil Alam, Farhana Sultana, Afsana Bhuiyan, Nazmul Alam, Laura Reichenbach, Lena Marions, Mustafizur Rahman, Quamrun Nahar
BACKGROUND: The objective of this study was to assess the level of knowledge of cervical cancer among Bangladeshi women and to assess their willingness to receive the human papillomavirus (HPV) vaccine. METHODS: A population-based, cross-sectional survey was conducted from July to December 2011 in one urban and one rural area of Bangladesh. A total of 2037 ever-married women, aged 14 to 64 years, were interviewed using a structured questionnaire. Data on socio-demographic characteristics and knowledge of cervical cancer were collected...
January 11, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29325409/all-health-partnerships-great-and-small-comparing-mandated-with-emergent-health-partnerships-comment-on-evaluating-global-health-partnerships-a-case-study-of-a-gavi-hpv-vaccine-application-process-in-uganda
#17
Elaine Green, Dan Ritman, Graeme Chisholm
The plurality of healthcare providers and funders in low- and middle-income countries (LMICs) has given rise to an era in which health partnerships are becoming the norm in international development. Whether mandated or emergent, three common drivers are essential for ensuring successful health partnerships: trust; a diverse and inclusive network; and a clear governance structure. Mandated and emergent health partnerships operate as very different models and at different scales. However, there is potential for sharing and learning between these types of partnerships...
June 11, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29315236/understanding-the-role-of-intrinsic-disorder-of-viral-proteins-in-the-oncogenicity-of-different-types-of-hpv
#18
Elvira Regina Tamarozzi, Silvana Giuliatti
Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens. Among these pathogens, we have highlighted the human papillomavirus (HPV) in this study. HPV is currently among the most common sexually transmitted infections, besides being the cause of several types of cancer...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29289384/the-vaccine-hesitancy-scale-psychometric-properties-and-validation
#19
Gilla K Shapiro, Ovidiu Tatar, Eve Dube, Rhonda Amsel, Barbel Knauper, Anila Naz, Samara Perez, Zeev Rosberger
INTRODUCTION: The SAGE Working Group on Vaccine Hesitancy developed a vaccine hesitancy measure, the Vaccine Hesitancy Scale (VHS). This scale has the potential to aid in the advancement of research and immunization policy but has not yet been psychometrically evaluated. METHODS: Using a cross-sectional design, we collected self-reported survey data from a large national sample of Canadian parents from August to September 2016. An online questionnaire was completed in English or French...
December 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29285184/modulation-of-dna-methylation-by-human-papillomavirus-e6-and-e7-oncoproteins-in-cervical-cancer
#20
Prakriti Sen, Pooja Ganguly, Niladri Ganguly
Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection. The early oncoproteins E6 and E7 are important in this cellular transformation process. Epigenetic mechanisms have long been known to result in decisive alterations in DNA, leading to alterations in DNA-protein interactions, alterations in chromatin structure and compaction and significant alterations in gene expression. The enzymes responsible for these epigenetic modifications are DNA methyl transferases (DNMTs), histone acetylases and deacetylases...
January 2018: Oncology Letters
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