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https://www.readbyqxmd.com/read/27898730/plasma-lipid-profiling-of-patients-with-chronic-ocular-complications-caused-by-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#1
Kosuke Saito, Mayumi Ueta, Keiko Maekawa, Chie Sotozono, Shigeru Kinoshita, Yoshiro Saito
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are drug-induced acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface. Even after recovery from skin symptoms, some SJS/TEN patients continue to suffer with severe ocular complications (SOCs). Therefore, this study aims to understand the pathophysiology of chronic SOCs. Because plasma lipid profiling has emerged as a useful tool to understand pathophysiological alterations in the body, we performed plasma lipid profiling of 17 patients who suffered from SJS/TEN-associated chronic SOCs...
2016: PloS One
https://www.readbyqxmd.com/read/27725302/new-perspectives-on-dry-eye-definition-and-diagnosis-a-consensus-report-by-the-asia-dry-eye-society
#2
Kazuo Tsubota, Norihiko Yokoi, Jun Shimazaki, Hitoshi Watanabe, Murat Dogru, Masakazu Yamada, Shigeru Kinoshita, Hyo-Myung Kim, Hung-Won Tchah, Joon Young Hyon, Kyung-Chul Yoon, Kyoung Yul Seo, Xuguang Sun, Wei Chen, Lingyi Liang, Li Mingwu, Zuguo Liu
For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: "Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage...
October 7, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27557910/vestibular-evoked-myogenic-potentials-in-vestibular-migraine-do-they-help-differentiating-from-meni%C3%A3-re-s-disease
#3
Aki Inoue, Naoya Egami, Chisato Fujimoto, Makoto Kinoshita, Tatsuya Yamasoba, Shinichi Iwasaki
OBJECTIVE: To investigate whether both cervical and ocular vestibular myogenic potentials (cVEMPs and oVEMPs) to air-conducted sound (ACS) and bone-conducted vibration (BCV) can help to differentiate vestibular migraine (VM) and Menière's disease (MD). STUDY DESIGN: Retrospective study. SETTINGS: A tertiary referral center. SUBJECTS AND METHODS: Twenty-eight patients with VM, 28 patients with definite unilateral MD, and 28 age-matched controls were included...
November 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27297822/impact-of-cigarette-smoking-on-tear-function-and-correlation-between-conjunctival-goblet-cells-and-tear-muc5ac-concentration-in-office-workers
#4
Yuichi Uchino, Miki Uchino, Norihiko Yokoi, Murat Dogru, Motoko Kawashima, Aoi Komuro, Yukiko Sonomura, Hiroaki Kato, Pablo Argüeso, Shigeru Kinoshita, Kazuo Tsubota
The first aim of this study was to clarify whether cigarette smoking affects tear secretion, goblet cell density, and tear MUC5AC concentration. The second purpose was to evaluate the correlations of conjunctival goblet cell density with tear MUC5AC concentration and other ocular surface evaluation factors. This cross-sectional study included 88 office workers. All subjects were required to fill in dry eye and smoking questionnaires, in addition to ocular surface evaluation. Tear wash fluid was collected from inferior fornix, and conjunctival epithelium was obtained by impression cytology...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27193492/integrin-%C3%AE-4-is-a-major-target-antigen-in-pure-ocular-mucous-membrane-pemphigoid
#5
Xiaoguang Li, Hua Qian, Ryosuke Sogame, Yoshiaki Hirako, Daisuke Tsuruta, Norito Ishii, Hiroshi Koga, Atsunari Tsuchisaka, Zhexiong Jin, Kazuo Tsubota, Akiko Fukumoto, Chie Sotozono, Shigeru Kinoshita, Takashi Hashimoto
Previous studies of ocular mucous membrane pemphigoid (OMMP) have identified several components of the basement membrane zone to be autoantigens, including integrin β4. However, there are no extensive or definitive reported studies that address this, particularly in pure OMMP. To clarify the major autoantigens in pure OMMP. In this study, we examined sera from 43 pure OMMP patients for both IgG and IgA antibodies using newly developed immunoblotting analyses with a hemidesmosome-rich fraction and various recombinant proteins of integrin α6β4, in addition to our routine immune-serological tests...
June 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27055679/the-increase-of-aqueous-tear-volume-by-diquafosol-sodium-in-dry-eye-patients-with-sj%C3%A3-gren-s-syndrome-a-pilot-study
#6
N Yokoi, H Kato, S Kinoshita
PurposeTo investigate the effect of 3% diquafosol sodium ophthalmic solution (DQS) on aqueous tear volume increase in dry-eye patients with Sjögren's syndrome (SS).MethodsIn this pilot study, 17 dry-eye patients with SS (1 male and 16 females; mean age: 66.4 years) were enrolled and underwent topical instillation of two ophthalmic solutions, artificial tears (AT) in one eye and DQS in the fellow eye, in a masked manner. The central lower tear meniscus radius (TMR) curvature was measured before and at 15 min after instillation by video-meniscometry...
June 2016: Eye
https://www.readbyqxmd.com/read/26998714/effect-of-the-rho-associated-kinase-inhibitor-eye-drop-ripasudil-on-corneal-endothelial-wound-healing
#7
Naoki Okumura, Yugo Okazaki, Ryota Inoue, Kazuya Kakutani, Shinichiro Nakano, Shigeru Kinoshita, Noriko Koizumi
PURPOSE: Ripasudil (Glanatec), a selective rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, was approved as a glaucoma and ocular hypertension treatment in Japan in 2014. The purpose of this study was to investigate the feasibility of using ripasudil eye drops to treat corneal endothelial injuries. METHODS: Cultured human corneal endothelial cells (HCECs) were treated with ripasudil, and 5-bromo-2'-deoxyuridine (BrdU) incorporation was evaluated by ELISA...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26978026/visualization-of-intravital-immune-cell-dynamics-after-conjunctival-surgery-using-multiphoton-microscopy
#8
Sachi Kojima, Toshihiro Inoue, Junichi Kikuta, Masayuki Furuya, Ayaka Koga, Tomokazu Fujimoto, Mayumi Ueta, Shigeru Kinoshita, Masaru Ishii, Hidenobu Tanihara
PURPOSE: To visualize intravital immune cell dynamics in the subconjunctival tissue during the wound-healing process using multiphoton microscopy. METHODS: Gene-targeted mice expressing enhanced green fluorescent protein under the control of the endogenous lysozyme M promoter (LysM-eGFP mice) were anesthetized with isoflurane, and injured by a 10-0 nylon conjunctival suture. Vessels were visualized by intravenous injection of 70 kDa rhodamine-conjugated dextran...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26882981/acute-and-chronic-ophthalmic-involvement-in-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-comprehensive-review-and-guide-to-therapy-ii-ophthalmic-disease
#9
REVIEW
Sahar Kohanim, Sotiria Palioura, Hajirah N Saeed, Esen K Akpek, Guillermo Amescua, Sayan Basu, Preston H Blomquist, Charles S Bouchard, John K Dart, Xiaowu Gai, José A P Gomes, Darren G Gregory, Geetha Iyer, Deborah S Jacobs, Anthony J Johnson, Shigeru Kinoshita, Iason S Mantagos, Jodhbir S Mehta, Victor L Perez, Stephen C Pflugfelder, Virender S Sangwan, Kimberly C Sippel, Chie Sotozono, Bhaskar Srinivasan, Donald T H Tan, Radhika Tandon, Scheffer C G Tseng, Mayumi Ueta, James Chodosh
Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immune-mediated disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. Part I of this review focused on the systemic aspects of SJS/TEN and was published in the January 2016 issue of this journal...
April 2016: Ocular Surface
https://www.readbyqxmd.com/read/26869815/amniotic-membrane-assisted-trabeculectomy-for-refractory-glaucoma-with-corneal-disorders
#10
Kazuhiko Mori, Yoko Ikeda, Yuko Maruyama, Shigeta Naruse, Morio Ueno, Shigeru Kinoshita
PURPOSE: To report the cases of six consecutive patients who underwent amniotic membrane (AM)-assisted trabeculectomy (TLE) to treat refractory glaucoma with severe corneal disorders. METHODS: This study involved six patients (three males and three females, mean age: 69.5±15.8 years) with refractory glaucoma and severe corneal disorders. The surgical procedure for each patient involved trabecular tissue being excised, and human AM then being placed epithelial side up on the corneal surface, sutured at the limbal sclera, and flipped over onto the sclera to cover the TLE area...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/26843453/elevated-expression-of-abcb5-in-ocular-surface-squamous-neoplasia
#11
Passara Jongkhajornpong, Takahiro Nakamura, Chie Sotozono, Maho Nagata, Tsutomu Inatomi, Shigeru Kinoshita
ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal homeostasis. ABCB5 expression has also been discovered in the subpopulation of several cancer cells containing the cancer stem cell (CSC). However, the pathogenetic relationship between LSC and CSC and ABCB5 in the ocular surface squamous neoplasm (OSSN) is still entirely unknown. To improve understanding of the role of ABCB5 in OSSN, we performed immunohistochemistry for ABCB5 in nine OSSN case series...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26829569/stevens-johnson-syndrome-the-role-of-an-ophthalmologist
#12
REVIEW
Rajat Jain, Namrata Sharma, Sayan Basu, Geetha Iyer, Mayumi Ueta, Chie Sotozono, Chitra Kannabiran, Varsha M Rathi, Nidhi Gupta, Shigeru Kinoshita, José A P Gomes, James Chodosh, Virender S Sangwan
Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. Acute SJS leads to the acute inflammation of the ocular surface and chronic conjunctivitis. If not properly treated, it causes chronic cicatricial conjunctivitis and cicatricial lid margin abnormalities. Persistent inflammation and ulceration of the ocular surface with cicatricial complications of the lids leads to chronic ocular sequelae, ocular surface damage, and corneal scarring. The destruction of the glands that secrete the tear film leads to a severe form of dry eye that makes the management of chronic SJS difficult...
July 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26817134/-severe-ocular-infection-in-elderly-patients-with-dementia-a-case-study
#13
Yuka Miyamura, Chie Sotozono, Hisayo Higashihara, Saichi Hoshi, Shigeru Kinoshita
UNLABELLED: Purpose : To report 3 cases of severe ocular infection in elderly patients with dementia. CASE REPORTS: Case 1 involved a 75-year-old man who presented after his wife noticed hyperemia and discharge in his right eye. Corneal infection with perforation was found. Wife-administered antibiotics healed the infection within 1 month. Case 2 involved a 97-year-old man who was referred to us after nursing-home staff members noticed redness and discharge in his right eye...
December 2015: Nippon Ganka Gakkai Zasshi
https://www.readbyqxmd.com/read/26780319/induction-of-functional-3d-ciliary-epithelium-like-structure-from-mouse-induced-pluripotent-stem-cells
#14
Hirofumi Kinoshita, Kiyoshi Suzuma, Jun Kaneko, Michiko Mandai, Takashi Kitaoka, Masayo Takahashi
PURPOSE: To generate ciliary epithelium (CE) from mouse induced pluripotent stem (iPS) cells. METHODS: Recently, a protocol for self-organizing optic cup morphogenesis in three-dimensional culture was reported, and it was suggested that ocular tissue derived from neural ectoderm could be differentiated. We demonstrated that a CE-like double-layered structure could be induced in simple culture by using a modified Eiraku differentiation protocol. RESULTS: Differentiation of a CE-like double-layered structure could be promoted by glycogen synthase kinase 3β (GSK-3β) inhibitor...
January 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26780309/case-control-pilot-study-of-soft-contact-lens-wearers-with-corneal-infiltrative-events-and-healthy-controls
#15
MULTICENTER STUDY
Kathryn Richdale, Dawn Y Lam, Heidi Wagner, Aaron B Zimmerman, Beth T Kinoshita, Robin Chalmers, Luigina Sorbara, Loretta Szczotka-Flynn, Usha Govindarajulu, G Lynn Mitchell
PURPOSE: The purpose of this study was to assess risk factors associated with soft contact lens (SCL)-related corneal infiltrative events (CIEs). METHODS: This was a single-visit, case-control study conducted at five academic centers in North America. Cases were defined as current SCL wearers with a symptomatic CIE. For each case, three age- and sex-matched controls were enrolled. Subjects completed the Contact Lens Risk Survey (CLRS), a standardized scripted medical interview, supplied a recent health history, and underwent an ocular examination...
January 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26655481/analysis-of-ocular-manifestation-and-genetic-association-of-allopurinol-induced-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-south-korea
#16
Hyo Seok Lee, Mayumi Ueta, Mee Kum Kim, Kyoung Yul Seo, Chie Sotozono, Shigeru Kinoshita, Kyung Chul Yoon
PURPOSE: To describe the clinical characteristics and genetic background of allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in South Korea. METHODS: This is a prospective, noncomparative case series. Visual acuity, detailed medical history, ocular findings, and systemic manifestations of 5 patients (10 eyes) with allopurinol-induced SJS/TEN were recorded. The acute ocular involvement score and the chronic ocular manifestation score were graded on scales of 0-3 and 0-39, respectively, based on severity...
February 2016: Cornea
https://www.readbyqxmd.com/read/26618648/rho-associated-kinase-inhibitor-eye-drop-ripasudil-transiently-alters-the-morphology-of-corneal-endothelial-cells
#17
Naoki Okumura, Yugo Okazaki, Ryota Inoue, Shinichiro Nakano, Nigel J Fullwood, Shigeru Kinoshita, Noriko Koizumi
PURPOSE: Ripasudil (Glanatec), a selective Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, was approved in Japan in September 2014 for the treatment of glaucoma and ocular hypertension. The purpose of this study was to investigate the effect of ripasudil eye drops on corneal endothelial morphology, as ROCK signaling is known to modulate the actin cytoskeleton. METHODS: Morphological changes in the corneal endothelium were evaluated in human subjects by specular and slit-lamp microscopy, following topical administration of ripasudil...
November 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26549248/stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-comprehensive-review-and-guide-to-therapy-i-systemic-disease
#18
REVIEW
Sahar Kohanim, Sotiria Palioura, Hajirah N Saeed, Esen K Akpek, Guillermo Amescua, Sayan Basu, Preston H Blomquist, Charles S Bouchard, John K Dart, Xiaowu Gai, José A P Gomes, Darren G Gregory, Geetha Iyer, Deborah S Jacobs, Anthony J Johnson, Shigeru Kinoshita, Iason S Mantagos, Jodhbir S Mehta, Victor L Perez, Stephen C Pflugfelder, Virender S Sangwan, Kimberly C Sippel, Chie Sotozono, Bhaskar Srinivasan, Donald T H Tan, Radhika Tandon, Scheffer C G Tseng, Mayumi Ueta, James Chodosh
The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon...
January 2016: Ocular Surface
https://www.readbyqxmd.com/read/26435683/methicillin-resistant-staphylococcus-aureus-ulcerative-keratitis-in-a-thoroughbred-racehorse
#19
Taisuke Kuroda, Yuta Kinoshita, Hidekazu Niwa, Fumiaki Mizobe, Takanori Ueno, Atsutoshi Kuwano, Takashi Hatazoe, Seiji Hobo
We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) keratitis in a racehorse. A 5-year-old mare developed punctate keratitis after racing. The corneal ulcer continued to expand despite ophthalmic antimicrobial therapy. On day 6, a conjunctival graft surgery was performed. The mare was euthanized, following colitis and laminitis development on day 10. MRSA was isolated from the corneal swab taken at the time of euthanasia. Immunohistochemical analysis demonstrated gram-positive and anti-S...
2015: Journal of Equine Science
https://www.readbyqxmd.com/read/26424376/jbp485-promotes-corneal-epithelial-wound-healing
#20
Maho Nagata, Takahiro Nakamura, Yuiko Hata, Shumpei Yamaguchi, Taiichi Kaku, Shigeru Kinoshita
Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage...
2015: Scientific Reports
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