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https://www.readbyqxmd.com/read/29343542/clinical-validation-of-the-sensitest%C3%A2-colistin-a-broth-microdilution-based-method-to-evaluate-colistin-mics
#1
Edoardo Carretto, Flavia Brovarone, Giuseppe Russello, Paola Nardini, Maisra El-Bouseary, Ali Aboklaish, Timothy R Walsh, Jonathan M Tyrrell
The global spread of multi-drug resistant Gram negative has led to the return of colistin for treating severe infections. Recently, different plasmid-mediated genes conferring resistance to this drug were described and reported worldwide. International committees (EUCAST/CLSI) re-evaluated inconsistencies surrounding colistin antimicrobial susceptibility testing (AST), concluding that broth microdilution (BMD) should serve as the reference method for AST. The development of an accurate, reproducible commercial test based on BMD is therefore highly desirable...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29342972/the-effect-of-combining-natural-terpenes-and-antituberculous-agents-against-reference-and-clinical-mycobacterium-tuberculosis-strains
#2
Elwira Sieniawska, Rafal Sawicki, Marta Swatko-Ossor, Agnieszka Napiorkowska, Agata Przekora, Grazyna Ginalska, Ewa Augustynowicz-Kopec
Background: On account of emergence of multi- and extensively drug-resistant Mycobacterium tuberculosis (Mtb) strains, combinations of drugs with natural compounds were tested to search for antibiotic activity enhancers. In this work we studied terpenes (α-pinene, bisabolol, β-elemene, (R)-limonene, (S)-limonene, myrcene, sabinene), which are the main constituents of essential oil obtained from Mutellina purpurea L., a plant with described antitubercular activity, to investigate their interactions with antibiotics against reference Mtb strains and multidrug-resistant clinical isolates...
January 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342216/in-vitro-activity-of-novel-glycopolymer-against-clinical-isolates-of-multidrug-resistant-staphylococcus-aureus
#3
Vidya P Narayanaswamy, Scott A Giatpaiboon, John Uhrig, Paul Orwin, William Wiesmann, Shenda M Baker, Stacy M Townsend
The incidence of multidrug-resistant (MDR) organisms, including methicillin-resistant Staphylococcus aureus (MRSA), is a serious threat to public health. Progress in developing new therapeutics is being outpaced by antibiotic resistance development, and alternative agents that rapidly permeabilize bacteria hold tremendous potential for treating MDR infections. A new class of glycopolymers includes polycationic poly-N (acetyl, arginyl) glucosamine (PAAG) is under development as an alternative to traditional antibiotic strategies to treat MRSA infections...
2018: PloS One
https://www.readbyqxmd.com/read/29340910/resistance-mechanism-in-a-terbinafine-resistant-strain-of-microsporum-canis
#4
Rui Kano, Yun-Hsia Hsiao, Han Hock Siew, Charles Chen, Atsuhiko Hasegawa, Hiroshi Kamata
To clarify the terbinafine (TRF) resistance mechanism in a TRF-resistant strain of Microsporum canis, the expression of the pleiotropic drug resistance (PDR1), multidrug resistance (MDR1), MDR2 and MDR4 genes were investigated by real-time quantitative PCR (RT-qPCR) analysis, given the known interaction of the corresponding proteins with antifungals and with the efflux blocker FK506. The expression of the PDR1, MDR1, MDR2 and MDR4 genes was 2-4 times higher in the TRF-resistant strain grown in the presence of 0...
January 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29340060/assessment-of-antimicrobial-and-wound-healing-effects-of-brevinin-2ta-against-the-bacterium-klebsiella-pneumoniae-in-dermally-wounded-rats
#5
Siqin Liu, Qilin Long, Yang Xu, Jun Wang, Zhongwei Xu, Lei Wang, Mei Zhou, Yuxin Wu, Tianbao Chen, Chris Shaw
Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates. Here, we isolated and identified a novel AMP Brevinin-2Ta (B-2Ta) from the skin secretion of the European frog, Pelophylax kl. esculentus. In vitro studies revealed that it showed broad antimicrobial activities against S. aureus, E. coli and C...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339382/in-vitro-susceptibility-of-neisseria-gonorrhoeae-strains-to-mupirocin-an-antibiotic-reformulated-to-parenteral-nano-liposomal-antibiotic
#6
Ahuva Cern, Kristie L Connolly, Ann E Jerse, Yechezkel Barenholz
Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the minimum inhibitory concentrations (MIC) of mupirocin to be 0.0039-0.0625 μg/ml for 94 N. gonorrhoeae strains Cross-resistance with other antibiotics was not detected.Mupirocin, currently limited to topical administration, demonstrated activity by injection when delivered in nano-liposomes. The nano-liposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29337135/defining-bedaquiline-susceptibility-resistance-cross-resistance-and-associated-genetic-determinants-a-retrospective-cohort-study
#7
Nazir A Ismail, Shaheed V Omar, Lavania Joseph, Netricia Govender, Linsay Blows, Farzana Ismail, Hendrik Koornhof, Andries W Dreyer, Koné Kaniga, Norbert Ndjeka
BACKGROUND: Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess interpretive criteria against putative resistance associated variants (RAVs), microbiological outcomes and cross resistance with clofazimine (CFZ). METHODS: A retrospective cohort study was conducted. Minimal inhibitory concentrations (MIC) to BDQ were determined using 7H9 broth microdilution (BMD) and MGIT960...
January 9, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29335214/in%C3%A2-vivo-potent-bm635-analogue-with-improved-drug-like-properties
#8
Giovanna Poce, Martina Cocozza, Salvatore Alfonso, Sara Consalvi, Giulia Venditti, Raquel Fernandez-Menendez, Robert H Bates, David Barros Aguirre, Lluis Ballell, Alessandro De Logu, Giulio Vistoli, Mariangela Biava
BM635 is the hit compound of a promising anti-TB compound class. Herein we report systematic variations around the central pyrrole core of BM635 and we describe the design, synthesis, biological evaluation, pharmacokinetic analysis, as well as in vivo TB mouse efficacy studies of novel BM635 analogues that show improved physicochemical properties. This hit-to-lead campaign led to the identification of a new analogue, 4-((1-isopropyl-5-(4-isopropylphenyl)-2-methyl-1H-pyrrol-3-yl)methyl)morpholine (17), that shows excellent activity (MIC = 0...
December 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29334931/in-vitro-antibacterial-and-antibiotic-modifying-activity-of-crude-extract-fractions-and-3-4-7-trihydroxyflavone-from-myristica-fragrans-houtt-against-mdr-gram-negative-enteric-bacteria
#9
Joachim K Dzotam, Ingrid Konga Simo, Gabin Bitchagno, Ilhami Celik, Louis P Sandjo, Pierre Tane, Victor Kuete
BACKGROUND: Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present study thus aimed to investigate the in vitro antibacterial activity and antibiotic modifying activities of crude seed kernel methanol extract (MFS), fractions (MFSa-e) as well as 3',4',7-trihydroxyflavone from Myristica fragrans against a panel of multi-drug resistant (MDR) Gram-negative bacteria...
January 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29333608/the-synergistic-effect-of-pdt-and-oxacillin-on-clinical-isolates-of-staphylococcus-aureus
#10
Natanel Iluz, Yasmin Maor, Natan Keller, Zvi Malik
BACKGROUND: Staphylococcus aureus is a major pathogen in clinical microbiology. It is known to cause infections at various body sites and can be life-threatening. The development of resistance to many well-established antibiotic treatments and the prevalence of methicillin-resistant S. aureus (MRAS) among hospital patients and the general community pose challenges in treating the pathogen. The antimicrobial effect of photodynamic therapy (PDT) has been a subject of study for a long time and can offer new strategies for dealing with resistant strains...
January 15, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29325762/assessment-of-in-vivo-efficacy-of-eravacycline-against-enterobacteriaceae-exhibiting-various-resistance-mechanisms-a-dose-ranging-study-and-pk-pd-analysis
#11
Abrar K Thabit, Marguerite L Monogue, Joseph V Newman, David P Nicolau
After the pharmacokinetic (PK) profile of eravacycline as a novel fluorocycline was defined, understanding its pharmacodynamic (PD) profile became essential. The aim of this study was to assess the correlation of the PK/PD index of the area under free drug concentration-time curve above the minimum inhibitory concentration (fAUC/MIC) and its magnitude with eravacycline's efficacy against Enterobacteriaceae isolates using the immunocompetent murine thigh infection model to resemble the immunocompetent environment in eravacycline's clinical trials...
January 8, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29325755/amphotericin-b-albumin-conjugates-synthesis-toxicity-and-anti-fungal-activity
#12
Sneha Gurudevan, Arul Prakash Francis, A Jayakrishnan
Amphotericin B (AmB), a hydrophobic drug with negligible aqueous solubility was conjugated to bovine serum albumin (BSA) via amide bond coupling to give 6 to 8 wt% drug payload. The resulting conjugate was characterized using SDS-PAGE and UV-visible, FTIR and CD spectroscopy. The conjugate was water-soluble to the extent of 150 mg/ml, was non-toxic to HEK 293 T cells at a concentration of 500 μg/ml (equivalent to ~30 μg AmB) and showed hemolysis of <5% at 200 μg/ml (equivalent to ~12 μg AmB) against human erythrocytes in vitro...
January 8, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29324718/screening-of-e-coli-%C3%AE-clamp-inhibitors-revealed-that-few-inhibit-helicobacter-pylori-more-effectively-structural-and-functional-characterization
#13
Preeti Pandey, Vijay Verma, Suman Kumar Dhar, Samudrala Gourinath
The characteristic of interaction with various enzymes and processivity-promoting nature during DNA replication makes β-clamp an important drug target. Helicobacter pylori (H. pylori) have several unique features in DNA replication machinery that makes it different from other microorganisms. To find out whether difference in DNA replication proteins behavior accounts for any difference in drug response when compared to E. coli, in the present study, we have tested E. coli β-clamp inhibitor molecules against H...
January 11, 2018: Antibiotics
https://www.readbyqxmd.com/read/29324696/quantitative-assessment-of-antimicrobial-activity-of-plga-films-loaded-with-4-hexylresorcinol
#14
Michael Kemme, Regina Heinzel-Wieland
Profound screening and evaluation methods for biocide-releasing polymer films are crucial for predicting applicability and therapeutic outcome of these drug delivery systems. For this purpose, we developed an agar overlay assay embedding biopolymer composite films in a seeded microbial lawn. By combining this approach with model-dependent analysis for agar diffusion, antimicrobial potency of the entrapped drug can be calculated in terms of minimum inhibitory concentrations (MICs). Thus, the topical antiseptic 4-hexylresorcinol (4-HR) was incorporated into poly(lactic-co-glycolic acid) (PLGA) films at different loadings up to 3...
January 11, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29324679/antibacterial-evaluation-and-virtual-screening-of-new-thiazolyl-triazole-schiff-bases-as-potential-dna-gyrase-inhibitors
#15
Cristina Nastasă, Dan C Vodnar, Ioana Ionuţ, Anca Stana, Daniela Benedec, Radu Tamaian, Ovidiu Oniga, Brînduşa Tiperciuc
The global spread of bacterial resistance to drugs used in therapy requires new potent and safe antimicrobial agents. DNA gyrases represent important targets in drug discovery. Schiff bases, thiazole, and triazole derivatives are considered key scaffolds in medicinal chemistry. Fifteen thiazolyl-triazole Schiff bases were evaluated for their antibacterial activity, measuring the growth inhibition zone diameter, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC), against Gram-positive (Staphylococcus aureus, Listeria monocytogenes) and Gram-negative (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa) bacteria...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29324337/amino-acid-conjugated-antimicrobial-drugs-synthesis-lipophilicity-activity-relationship-antibacterial-and-urease-inhibition-activity
#16
Atta Ullah, Fatima Iftikhar, Muhammad Arfan, Syeda Tayyaba Batool Kazmi, Muhammad Naveed Anjum, Ihsan-Ul Haq, Muhammad Ayaz, Sadia Farooq, Umer Rashid
Present work describes the in vitro antibacterial evaluation of some new amino acid conjugated antimicrobial drugs. Structural modification was attempted on the three existing antimicrobial pharmaceuticals namely trimethoprim, metronidazole, isoniazid. Twenty one compounds from seven series of conjugates of these drugs were synthesized by coupling with some selected Boc-protected amino acids. The effect of structural features and lipophilicity on the antibacterial activity was investigated. The synthesized compounds were evaluated against five standard American type culture collection (ATCC) i...
December 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29319497/comparison-of-the-treatment-efficacy-between-tigecycline-plus-high-dose-cefoperazone-sulbactam-and-tigecycline-monotherapy-against-ventilator-associated-pneumonia-caused-by-extensively-drug-resistant-acinetobacter-baumannii
#17
Youfa Qin, Jie Zhang, Lei Wu, Dailong Zhang, Lunjiao Fu, Xiaoyan Xue
OBJECTIVE: The present study examined the effect of high-dose cefoperazone-sulbactam combined with tigecycline against ventilator-associated pneumonia (VAP) caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). MATERIALS AND METHODS: 42 patients with VAP due to XDR-AB infection were randomized into two groups: the TIG group (received tigecycline injection) and the TIG+CFS group (received tigecycline and cefoperazone-sulbactam (1 : 1) injection)...
January 10, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29318401/synthesis-anti-microbial-activity-cytotoxicity-of-some-novel-substituted-5-3-1h-benzo-d-imidazol-2-yl-4-hydroxybenzyl-benzofuran-2-yl-phenyl-methanone-analogs
#18
Bhookya Shankar, Pochampally Jalapathi, Balabadra Saikrishna, Shaym Perugu, Vijjulatha Manga
BACKGROUND: There is a dire need for the discovery and development of new antimicrobial agents after several experiments for a better resistance of microorganisms towards antimicrobial agents become a serious health problem for a few years in the past. As benzimidazole possess various types of biological activities, it has been synthesized, in the present study, a new series of (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs by using the condensation and screened for its in vitro antimicrobial activity and cytotoxicity...
January 9, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29317824/selection-of-piperacillin-tazobactam-infusion-mode-guided-by-sofa-score-in-cancer-patients-with-hospital-acquired-pneumonia-a-randomized-controlled-study
#19
Yang Lyu, Yang Yang, Xin Li, Min Peng, Xin He, Peng Zhang, Shangwen Dong, Wanhua Wang, Donghao Wang
Background: This study aimed to select piperacillin/tazobactam (TZP) infusion mode guided by Sequential Organ Failure Assessment (SOFA) score in cancer patients with hospital-acquired pneumonia (HAP) postoperation. Patients and methods: A total of 120 cancer patients with postoperative HAP were divided into two groups: improved administration group (L group) and conventional treatment group (Con group). The Con group received traditional infusion of TZP and the L group received it as prolonged infusion...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29313570/fosfomycin-susceptibility-in-urinary-tract-enterobacteriaceae
#20
Bhargav Patel, Kinjal Patel, Anjali Shetty, Rajeev Soman, Camilla Rodrigues
Introduction: Antibiotic treatment of Urinary Tract Infections (UTI) is becoming increasingly difficult due to emergence of multi-drug resistant (ESBLs, AmpC, CRE) uropathogens. Fosfomycin is an old antibiotic that has evoked renewed interest with unique properties of not sharing any structural similarity and lack of cross-resistance with other antimicrobial agents. Our aim is to evaluate in-vitro activity of Fosfomycin against urinary tract Enterobacteriaceae. Material & Methods: The study period was March 2014 to September 2015...
September 2017: Journal of the Association of Physicians of India
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