keyword
https://read.qxmd.com/read/38524385/pancreatic-adenocarcinoma-of-the-tail-unveiling-a-rare-presentation-with-venous-thrombosis-a-case-report-and-literature-review
#21
Syeda Abiha Rabab, Syeda Mahrukh Fatima Zaidi, Ayesha Amjad, Paras, Maryam Sattar
Pancreatic cancer is a silent and lethal adversary that often conceals its presence until advanced stages. This report elucidates a distinctive case of a 46-year-old patient with pancreatic tail adenocarcinoma presenting with venous thrombosis, a rare manifestation. The patient's symptoms included severe left leg pain, swelling, and redness, accompanied by weight loss and decreased appetite. Laboratory findings indicated a prothrombotic state, whereas imaging revealed a substantial mass on the tail of the pancreas with hepatic metastasis...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38524280/pregnancy-associated-cancer-a-systematic-review-and-meta-analysis
#22
REVIEW
Ben Walters, India Midwinter, Carolyn A Chew-Graham, Kelvin P Jordan, Garima Sharma, Lucy C Chappell, Emma J Crosbie, Purvi Parwani, Mamas A Mamas, Pensée Wu
This study aimed to systematically evaluate and quantify the risk of adverse maternal and neonatal outcomes in patients with pregnancy-associated cancer (PAC). This study was conducted from February 13, 2021, through July 24, 2023. A systematic search of MEDLINE, Embase, Web of Science Core Collection, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials was conducted to identify studies reporting outcomes for patients with PAC. The study was registered on PROSPERO. Two reviewers independently conducted screening, data extraction, and quality assessment...
April 2024: Mayo Clinic Proceedings. Innovations, Quality & Outcomes
https://read.qxmd.com/read/38524024/assessing-the-impact-of-comorbid-hypercalcemia-on-inpatient-outcomes-of-patients-with-diffuse-large-b-cell-lymphoma-during-admission-for-chemotherapy
#23
JOURNAL ARTICLE
Dennis D Kumi, Vaishali Deenadayalan, Samuel M Odoi, Badri Aryal, Ekrem Turk, Ayobami Olafimihan, Khaldun Obeidat, Jay Vakil, Navika Chhabra, Maryam Zia
Introduction Diffuse large B-cell lymphoma (DLBCL) may be complicated by hypercalcemia at various stages of treatment. The impact of hypercalcemia on chemotherapy admission outcomes in DLBCL is not well described.  Methods In a retrospective analysis, using the National Inpatient Sample database (2018 - 2020), patients with DLBCL admitted for chemotherapy were dichotomized based on the presence of hypercalcemia. Our primary outcome was all-cause mortality. Secondary outcomes included length of stay (LOS), total charge, rate of acute kidney injury (AKI), tumor lysis syndrome (TLS), hyperkalemia, metabolic acidosis, acute encephalopathy, septic shock, Clostridiodes difficile infection, acute respiratory failure, and venous thromboembolic events (VTE)...
February 2024: Curēus
https://read.qxmd.com/read/38523134/american-association-for-the-surgery-of-trauma-american-college-of-surgeons-committee-on-trauma-clinical-protocol-for-post-discharge-venous-thromboembolism-prophylaxis-after-trauma
#24
JOURNAL ARTICLE
Allison E Berndtson, Alisa Cross, Brian K Yorkgitis, Ryan Kennedy, Matthew P Kochuba, Christopher Tignanelli, Gail T Tominaga, David G Jacobs, Dennis W Ashley, Eric J Ley, Lena Napolitano, Todd W Costantini
Trauma patients are at an elevated risk for developing venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis. In the inpatient setting, prompt pharmacologic prophylaxis is utilized to prevent VTE. For patients with lower extremity fractures or limited mobility, VTE risk does not return to baseline levels post-discharge. Currently, there are limited data to guide post-discharge VTE prophylaxis in trauma patients. The goal of these post-discharge VTE prophylaxis guidelines are to identify patients at the highest risk of developing VTE after discharge and to offer pharmacologic prophylaxis strategies to limit this risk...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38523132/exposure-to-statin-therapy-decreases-the-incidence-of-venous-thromboembolism-after-trauma
#25
JOURNAL ARTICLE
Kelly E Sanders, Gabrielle E Hatton, Atharwa R Mankame, Addison C Allen, Sarah Cunningham, Jan Michael Van Gent, Erin E Fox, Xu Zhang, Charles E Wade, Bryan A Cotton, Jessica C Cardenas
INTRODUCTION: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in trauma patients, despite chemoprophylaxis. Statins have been shown capable of acting upon the endothelium. We hypothesized that statin therapy in the pre- or in-hospital settings leads to a decreased incidence of VTE. METHODS: We conducted a retrospective cohort study of injured patients who received statin therapy pre- or in-hospital. Adult, highest-level trauma activation patients admitted January 2018 - June 2022 were included...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38522096/machine-learning-natural-language-processing-for-identifying-venous-thromboembolism-systematic-review-and-meta-analysis
#26
JOURNAL ARTICLE
Barbara D Lam, Pavlina Chrysafi, Thita Chiasakul, Harshit Khosla, Dimitra Karagkouni, Megan McNichol, Alys Adamski, Nimia Reyes, Karon Abe, Simon Mantha, Ioannis S Vlachos, Jeffrey I Zwicker, Rushad Patell
Venous thromboembolism (VTE) is a leading cause of preventable in-hospital mortality. Monitoring VTE cases is limited by the challenges of manual chart review and diagnosis code interpretation. Natural language processing (NLP) can automate the process. Rule-based NLP methods are effective but time consuming. Machine learning (ML)-NLP methods present a promising solution. We conducted a systematic review and meta-analysis of studies published before May 2023 that use ML-NLP to identify VTE diagnoses in the electronic health records...
March 24, 2024: Blood Advances
https://read.qxmd.com/read/38521850/real-world-outcomes-of-dual-advanced-therapy-in-children-and-young-adults-with-inflammatory-bowel-disease
#27
JOURNAL ARTICLE
Amelia Kellar, Michael T Dolinger, Elizabeth A Spencer, Marla C Dubinsky
BACKGROUND: Data are limited on the safety and efficacy of combining advanced therapies for refractory patients with IBD. AIM: To evaluate the real-world efficacy and safety of dual advanced therapy (DAT), combining 2 biologics or a biologic with a small molecule, in children and young adults with refractory IBD. METHODS: Primary outcome of this single IBD center cohort was DAT remission (clinical and biomarker remission) at first assessment (T1)...
March 23, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38521524/tailored-anticoagulant-treatment-after-a-first-venous-thromboembolism-protocol-of-the-leiden-thrombosis-recurrence-risk-prevention-l-trrip-study-cohort-based-randomised-controlled-trial
#28
JOURNAL ARTICLE
J Louise I Burggraaf-van Delft, Nienke van Rein, Remy H H Bemelmans, Jan-Willem K van den Berg, Coty Y Bruggeman, Marissa Cloos-van Balen, Michiel Coppens, Matthijs Eefting, Yvonne Ende-Verhaar, Nick van Es, Coen van Guldener, Wouter K de Jong, Fleur Kleijwegt, Ted Koster, Cees Kroon, Saskia Kuipers, Jenneke Leentjens, Dieuwke Luijten, Albert T A Mairuhu, Karina Meijer, Marcel A van de Ree, Rick Roos, Ilse Schrover, Janneke Swart-Heikens, Annette W G van der Velden, Elske M van den Akker-van Marle, Saskia le Cessie, Geert-Jan Geersing, Saskia Middeldorp, Menno V Huisman, Frederikus A Klok, Suzanne C Cannegieter
INTRODUCTION: Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain whether patients with an intermediate recurrence risk or with a high recurrence and high bleeding risk will benefit from extended anticoagulant treatment, and whether a strategy where anticoagulant duration is tailored on the predicted risks of rVTE and bleeding can improve outcomes...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521508/combined-polygenic-scores-for-ischemic-stroke-risk-factors-aid-risk-assessment-of-ischemic-stroke
#29
JOURNAL ARTICLE
Sarah Huang, Abhishek Joshi, Zhuqing Shi, Jun Wei, Huy Tran, S Lilly Zheng, David Duggan, Annabelle Ashworth, Liana Billings, Brian T Helfand, Arman Qamar, Zachary Bulwa, Alfonso Tafur, Jianfeng Xu
BACKGROUND: Current risk assessment for ischemic stroke (IS) is limited to clinical variables. We hypothesize that polygenic scores (PGS) of IS (PGSIS ) and IS-associated diseases such as atrial fibrillation (AF), venous thromboembolism (VTE), coronary artery disease (CAD), hypertension (HTN), and Type 2 diabetes (T2D) may improve the performance of IS risk assessment. METHODS: Incident IS was followed for 479,476 participants in the UK Biobank who did not have an IS diagnosis prior to the recruitment...
March 21, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38521460/tranexamic-acid-reduces-perioperative-blood-loss-and-postoperative-hemoglobin-loss-during-total-ankle-arthroplasty-a-systematic-review-and-meta-analysis-of-clinical-comparative-studies
#30
REVIEW
James J Butler, Ragul Rajivan, Kishore Konar, Utkarsh Anil, Mohammad T Azam, Raymond Walls, John G Kennedy
IMPORTANCE: Peri-operative blood loss during joint replacement procedures is a modifiable risk factor that impacts wound complications, hospital stay and total costs. Tranexamic acid (TXA) is an anti-fibrinolytic that has been widely used in orthopedic surgery, but its efficacy in the setting of total ankle arthroplasty (TAA) has not been quantified to date. AIM: The purpose of this systematic review and meta-analysis was to evaluate the efficacy and safety of administering TXA in patients undergoing TAA...
March 21, 2024: Journal of ISAKOS
https://read.qxmd.com/read/38521193/assessment-of-the-clot-children-s-likelihood-of-thrombosis-real-time-risk-prediction-model-of-hospital-associated-venous-thromboembolism-in-children-with-congenital-heart-disease
#31
JOURNAL ARTICLE
Sudeep D Sunthankar, Ryan P Moore, Daniel W Byrne, Henry J Domenico, Allison P Wheeler, Shannon C Walker, Prince J Kannankeril
BACKGROUND: Children with congenital heart disease (CHD) are at high risk for hospital-associated venous thromboembolism (HA-VTE). The Children's Likelihood of Thrombosis (CLOT) trial validated a real-time predictive model for HA-VTE using data extracted from the EHR for pediatric inpatients. We tested the hypothesis that addition of CHD specific data would improve model prediction in the CHD population. METHODS: Model performance in CHD patients from 2010-2022, was assessed using three iterations of the CLOT model: 1) the original CLOT model, 2) the original model refit using only data from the CHD cohort, and 3) the model updated with the addition of cardiopulmonary bypass time, STAT mortality category, height, and weight as covariates...
March 21, 2024: American Heart Journal
https://read.qxmd.com/read/38518208/weight-based-dosing-for-low-molecular-weight-heparin-enoxaparin-administration-to-achieve-optimal-vte-prophylaxis-in-trauma-patients
#32
JOURNAL ARTICLE
Tarendeep Thind, Thomas Heye, Curran Henson, Rebecca Reif, Hanna K Jensen, Kyle J Kalkwarf, Avi Bhavaraju, Ronald Robertson, Allison Jenkins
INTRODUCTION: Patients admitted after traumatic injuries are at high risk for developing venous thromboembolism (VTE). Low-molecular-weight heparin (LMWH) is commonly used to prevent VTE in this patient population; however, the optimal dosing strategy has yet to be determined. To address this question, a fixed-dosing strategy of LMWH was compared to a weight-based dosing strategy of LMWH for VTE prophylaxis. METHODS: A retrospective, pre-post implementation cohort study compared a fixed vs a weight-based dosing strategy of LMWH for VTE prophylaxis...
March 22, 2024: American Surgeon
https://read.qxmd.com/read/38515559/an-effective-protocol-for-perioperative-venous-thromboembolism-prophylaxis-in-diep-flap-breast-reconstruction-a-single-institution-retrospective-review
#33
JOURNAL ARTICLE
Mathew L Moreno, Hunter Essex, Meredith Collins
BACKGROUND: Deep inferior epigastric artery perforator (DIEP) free flap breast reconstruction is one of the most highly used procedures for autologous breast reconstruction. Many venous thromboembolism (VTE) risk assessment models have been proposed in breast reconstructive surgery, including the widely used Caprini score. However, a paucity of data suggests an effective standardized VTE protocol. The purpose of this study was to determine the rate of VTE in our DIEP flap patients who were treated with this protocol...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38514281/comparison-of-enoxaparin-40%C3%A2-mg-versus-60%C3%A2-mg-dosage-for-venous-thromboprophylaxis-in-patients-undergoing-bariatric-surgery-a-randomized-controlled-trial
#34
JOURNAL ARTICLE
Kritsada Kongsawat, Komol Chaivanijchaya, Fon Pakul, Suthikiat Joradol, Pattharasai Kachornvitaya, Patchaya Boonchaya-Anant, Suthep Udomsawaengsup
BACKGROUND: Venous thromboembolism (VTE) is a common cause of morbidity and mortality after bariatric surgery. Morbid obesity is an independent risk factor for VTE, with goals of prophylactic anti-factor Xa levels within 0.2-0.5 IU/mL. The recommended dosing regimen of enoxaparin for VTE prophylaxis in patients with morbid obesity is lacking in available guidelines. OBJECTIVES: To evaluate the achieving prophylactic anti-factor Xa levels with different dosages of enoxaparin for morbid obesity patients...
March 20, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38513312/mechanical-properties-of-clot-made-from-human-and-bovine-whole-blood-differ-significantly
#35
JOURNAL ARTICLE
Gabriella P Sugerman, Grace N Bechtel, Zuzanna Malinowska, Sapun H Parekh, Manuel K Rausch
Thromboembolism - that is, clot formation and the subsequent fragmentation of clot - is a leading cause of death worldwide. Clots' mechanical properties are critical determinants of both the embolization process and the pathophysiological consequences thereof. Thus, understanding and quantifying the mechanical properties of clots is important to our ability to treat and prevent thromboembolic disease. However, assessing these properties from in vivo clots is experimentally challenging. Therefore, we and others have turned to studying in vitro clot mimics instead...
March 15, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38513233/paroxysmal-nocturnal-hemoglobinuria-related-thrombosis-in-the-era-of-novel-therapies-a-2043-patient-years-analysis
#36
JOURNAL ARTICLE
Carmelo Gurnari, Hussein Awada, Simona Pagliuca, Danai Dima, Fauzia Ullah, Naomi Kawashima, Yasuo Kubota, Ceylan Colak, Valeria Visconte, Bhumika J Patel, Vikram Dhillon, Naimisha Marneni, Suresh Kumar Balasubramanian, Ashwin Kishtagari, Taha Bat, Jaroslaw P Maciejewski
Thrombophilia is one of the principal features of paroxysmal nocturnal hemoglobinuria (PNH) and constitutes the main cause of disease morbidity/mortality. Anti-complement treatment has revolutionized the natural history of PNH with control of the hemolytic process and abolition of thrombotic events (TE). However, no guidelines exist for the management of thromboembolic complications in this setting, with type and duration of anti-coagulation depending on individual practices. Besides, a scarcity of data is present on the efficacy of direct oral anti-coagulants (DOACs)...
March 21, 2024: Blood
https://read.qxmd.com/read/38510855/effect-of-obesity-on-surgical-outcomes-and-complication-rates-in-pediatric-patients-a-comprehensive-systematic-review-and-meta-analysis
#37
REVIEW
Yeisson Rivero-Moreno, Andrea Garcia, Miguel Rivas-Perez, Jesus Coa-Bracho, Yoalkris Salcedo, Gabriel Gonzalez-Quinde, Erinor Montero-Palma, Denisse Valdivia-Sepulveda, Marialejandra Paz-Castillo, Debbye Machado-Paled, Wilson Garcia-Cazorla, Katheryn Acero-Alvarracín, Laila Tarabey-Yunis, Cesar Estrella-Gaibor
Obesity is one of the primary public health problems faced by children. The increased incidence of obesity in the pediatric population poses significant challenges during and after surgical procedures. This systematic review and meta-analysis aimed to understand to what extent obesity is to surgical complications in pediatric patients. A systematic database search of PubMed, Web of Science, Scopus, and Science Direct was performed in June 2023. According to the inclusion and exclusion criteria, two evaluators independently conducted literature screening, data extraction, and quality evaluation of the retrieved literature...
February 2024: Curēus
https://read.qxmd.com/read/38510506/the-changing-landscape-of-cardiac-co-morbidities-and-in-hospital-cardiac-complications-mediating-covid-19-mortality-between-2020-and-2021
#38
JOURNAL ARTICLE
Thomas R Basala, Marissa E Dulas, Alexis Albers, Sara D Olson, Brynn Okeson, Jay H Traverse
BACKGROUND: Cardiac co-morbidities and in-hospital cardiac complications significantly contribute to COVID-19 mortality. However, their influence on mortality between 2021 and 2020 may differ due to the availability of vaccines, different viral strains, and therapeutic advancements. METHODS: We performed a retrospective chart review and individual patient analysis of all COVID-19 associated in-patient deaths in 2020 ( n  = 346) and 2021( n  = 527) in a large Minneapolis health system...
January 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510294/the-pursuit-of-best-anticoagulant-for-cancer-associated-thrombosis-are-we-there-yet
#39
EDITORIAL
Tzu-Fei Wang, Jean M Connors
No abstract text is available yet for this article.
February 2024: JACC CardioOncology
https://read.qxmd.com/read/38510285/comparing-anticoagulation-strategies-for-venous-thromboembolism-associated-with-active-cancer-a-systematic-review-and-meta-analysis
#40
JOURNAL ARTICLE
Tomohiro Fujisaki, Daisuke Sueta, Eiichiro Yamamoto, Conor Buckley, Guilherme Sacchi de Camargo Correia, Julia Aronson, Paulino Tallón de Lara, Koichiro Fujisue, Hiroki Usuku, Kenichi Matsushita, Roxana Mehran, George D Dangas, Kenichi Tsujita
BACKGROUND: Current guidelines recommend several direct oral anticoagulant agents (DOACs) equally for managing cancer-associated venous thromboembolism (VTE). OBJECTIVES: The aim of this study was to assess the efficacy and safety of DOACs in patients with active cancer. METHODS: Literature searches were conducted in PubMed, Embase, and Cochrane Central in November 2022. Randomized controlled trials investigating anticoagulation strategies (vitamin K antagonists, parenteral anticoagulation [eg, low-molecular weight heparin], and DOACs) for VTE in patients with active cancer were identified for network meta-analysis...
February 2024: JACC CardioOncology
keyword
keyword
866
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.