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https://www.readbyqxmd.com/read/28646740/epigallocatechin-3-gallate-promotes-apoptosis-in-human-breast-cancer-t47d-cells-through-down-regulation-of-pi3k-akt-and-telomerase
#1
Maliheh Moradzadeh, Azar Hosseini, Saiedeh Erfanian, Hadi Rezaei
BACKGROUND: Green tea has antioxidant, anti-tumor and anti-bacterial properties. Epigallocatechin-3-gallate (EGCG) in green tea is highly active as a cancer chemopreventive agent. In this study, we designed a series of experiments to examine the effects of EGCG on proliferation and apoptosis of estrogen receptor α-positive breast cancer (T47D) cells. METHODS: Cells were treated with EGCG (0-80μM) and tamoxifen (0-20μM), as the positive control, up to 72h. Cell viability was determined by MTT assay...
April 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28646705/identification-and-in-vitro-characterization-of-novel-nanobodies-against-human-granulocyte-colony-stimulating-factor-receptor-to-provide-inhibition-of-g-csf-function
#2
Hamid Bakherad, Seyed Latif Mousavi Gargari, Zargham Sepehrizadeh, Hossein Aghamollaei, Ramezan Ali Taheri, Maryam Torshabi, Mojtaba Tabatabaei Yazdi, Walead Ebrahimizadeh, Neda Setayesh
It has been shown that Granulocyte colony-stimulating factor (G-CSF) has a higher expression in malignant tumors, and anti-G-CSF therapy considerably decreases tumor growth, tumor vascularization and metastasis. Thus, blocking the signaling pathway of G-CSF could be beneficial in cancer therapy. This study is aimed at designing and producing a monoclonal nanobody that could act as an antagonist of G-CSF receptor. Nanobodies are the antigen binding fragments of camelid single-chain antibodies, also known as VHH...
June 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28646593/mri-assisted-dual-motion-correction-for-myocardial-perfusion-defect-detection-in-pet-imaging
#3
Xinhui Wang, Arman Rahmim, Jing Tang
PURPOSE: Myocardial perfusion (MP) PET imaging is a powerful tool in risk assess-assessment and stratification of patients with coronary artery disease. Involuntary organmotion degrades cardiac PET image resolution while respiratory and/or cardiac gating to freeze the motion leads to noisier reconstructed images due to reduced counts in the gated frames. In this work, we propose an MRI assisted dual motion correction method to compensate for respiratory and cardiac motion in MP PET data and study the impact of dual motion correction on MP defect detection using systematically designed experiments...
June 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28646479/negative-body-attitudes-and-sexual-dissatisfaction-in-men-the-mediating-role-of-body-self-consciousness-during-physical-intimacy
#4
Femke van den Brink, Manja Vollmann, Lot C Sternheim, Lotte J Berkhout, Renée A Zomerdijk, Liesbeth Woertman
Previous research indicated that negative attitudes about the body and appearance are common among men and demonstrated that negative body attitudes are associated with negative sexual experiences. The present study investigated the association between body attitudes and sexual dissatisfaction and the mediating role of body self-consciousness during physical intimacy. In a cross-sectional design, 201 Dutch men completed an online survey regarding body attitudes toward muscularity, body fat, height, and genitals, body self-consciousness during physical intimacy, and sexual dissatisfaction...
June 23, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28646459/silymarin-inhibits-adipogenesis-in-the-adipocytes-in-grass-carp-ctenopharyngodon-idellus-in-vitro-and-in-vivo
#5
Peizhen Xiao, Zhou Yang, Jian Sun, Jingjing Tian, Zhiguang Chang, Xuexian Li, Baotong Zhang, Yuantu Ye, Hong Ji, Ermeng Yu, Jun Xie
In this study, two experiments were performed to explore the function of silymarin in adipogenesis in grass carp (Ctenopharyngodon idellus) using in vitro and in vivo models. In experiment 1, differentiated grass carp pre-adipocytes were treated with silymarin for 6 days. Treatment with 100 μg mL(-1)silymarin (SM100 group) significantly reduced triglyceride accumulation at day 6. The adipogenic gene expression levels of PPARγ, C/EBPα, SREBP1c, FAS, SCD1, and LPL, and the protein expression level of PPARγ were significantly down-regulated in the SM100 group...
June 23, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28646322/does-chess-instruction-improve-mathematical-problem-solving-ability-two-experimental-studies-with-an-active-control-group
#6
Giovanni Sala, Fernand Gobet
It has been proposed that playing chess enables children to improve their ability in mathematics. These claims have been recently evaluated in a meta-analysis (Sala & Gobet, 2016, Educational Research Review, 18, 46-57), which indicated a significant effect in favor of the groups playing chess. However, the meta-analysis also showed that most of the reviewed studies used a poor experimental design (in particular, they lacked an active control group). We ran two experiments that used a three-group design including both an active and a passive control group, with a focus on mathematical ability...
June 23, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28646002/preparation-for-transition-to-adult-care-among-medicaid-insured-adolescents
#7
Gregory S Sawicki, Katharine C Garvey, Sara L Toomey, Kathryn A Williams, J Lee Hargraves, Thomas James, Jean L Raphael, Angelo P Giardino, Mark A Schuster, Jonathan A Finkelstein
BACKGROUND: Parents of children with chronic illness consistently report suboptimal preparation for transition from pediatric- to adult-focused health care. Little data are available on transition preparation for low-income youth in particular. METHODS: We conducted a mailed survey of youth with chronic illness enrolled in 2 large Medicaid health plans to determine the quality of transition preparation using the Adolescent Assessment of Preparation for Transition (ADAPT)...
June 23, 2017: Pediatrics
https://www.readbyqxmd.com/read/28645979/the-2015-middle-childhood-survey-mcs-of-mental-health-and-well-being-at-age-11-years-in-an-australian-population-cohort
#8
Kristin R Laurens, Stacy Tzoumakis, Kimberlie Dean, Sally A Brinkman, Miles Bore, Rhoshel K Lenroot, Maxwell Smith, Allyson Holbrook, Kim M Robinson, Robert Stevens, Felicity Harris, Vaughan J Carr, Melissa J Green
PURPOSE: The Middle Childhood Survey (MCS) was designed as a computerised self-report assessment of children's mental health and well-being at approximately 11 years of age, conducted with a population cohort of 87 026 children being studied longitudinally within the New South Wales (NSW) Child Development Study. PARTICIPANTS: School Principals provided written consent for teachers to administer the MCS in class to year 6 students at 829 NSW schools (35.0% of eligible schools)...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645898/dna-pk-facilitates-piggybac-transposition-by-promoting-paired-end-complex-formation
#9
Yan Jin, Yaohui Chen, Shimin Zhao, Kun-Liang Guan, Yuan Zhuang, Wenhao Zhou, Xiaohui Wu, Tian Xu
The involvement of host factors is critical to our understanding of underlying mechanisms of transposition and the applications of transposon-based technologies. Modified piggyBac (PB) is one of the most potent transposon systems in mammals. However, varying transposition efficiencies of PB among different cell lines have restricted its application. We discovered that the DNA-PK complex facilitates PB transposition by binding to PB transposase (PBase) and promoting paired-end complex formation. Mass spectrometry analysis and coimmunoprecipitation revealed physical interaction between PBase and the DNA-PK components Ku70, Ku80, and DNA-PKcs Overexpression or knockdown of DNA-PK components enhances or suppresses PB transposition in tissue culture cells, respectively...
June 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28645845/the-feature-weighted-receptive-field-an-interpretable-encoding-model-for-complex-feature-spaces
#10
REVIEW
Ghislain St-Yves, Thomas Naselaris
We introduce the feature-weighted receptive field (fwRF), an encoding model designed to balance expressiveness, interpretability and scalability. The fwRFis organized around the notion of a feature map-a transformation of visual stimuli into visual features that preserves the topology of visual space (but not necessarily the native resolution of the stimulus). The key assumption of the fwRFmodel is that activity in each voxel encodes variation in a spatially localized region across multiple feature maps. This region is fixed for all feature maps; however, the contribution of each feature map to voxel activity is weighted...
June 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28645581/improvement-of-isopropanol-tolerance-of-escherichia-coli-using-adaptive-laboratory-evolution-and-omics-technologies
#11
Takaaki Horinouchi, Aki Sakai, Hazuki Kotani, Kumi Tanabe, Chikara Furusawa
Isopropanol (IPA) is the secondary alcohol that can be dehydrated to yield propylene. To produce IPA using microorganisms, a significant issue is that the toxicity of IPA causes retardation or inhibition of cell growth, decreasing the yield. One possible strategy to overcome this problem is to improve IPA tolerance of production organisms. For the understanding of tolerance to IPA, we performed parallel adaptive laboratory evolution (ALE) of Escherichia coli under IPA stress. To identify the genotypic change during ALE, we performed genome re-sequencing analyses of obtained tolerant strains...
June 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28645511/lamellae-spatial-distribution-modulates-fracture-behavior-and-toughness-of-african-pangolin-scales
#12
Michael J Chon, Matthew Daly, Bin Wang, Xianghui Xiao, Alireza Zaheri, Marc A Meyers, Horacio D Espinosa
Pangolin scales form a durable armor whose hierarchical structure offers an avenue towards high performance bio-inspired materials design. In this study, the fracture resistance of African pangolin scales is examined using single edge crack three-point bend fracture testing in order to understand toughening mechanisms arising from the structures of natural mammalian armors. In these mechanical tests, the influence of material orientation and hydration level are examined. The fracture experiments reveal an exceptional fracture resistance due to crack deflection induced by the internal spatial orientation of lamellae...
June 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28645445/fundamental-frequency-and-formants-before-and-after-prolonged-voice-use-in-teachers
#13
Ariane Damasceno Pellicani, Alice Ramos Fontes, Francisco Flavio Santos, Aline Damasceno Pellicani, Lilian Neto Aguiar-Ricz
OBJECTIVES: This study aimed to describe and correlate the fundamental frequency behavior and the first four formants before and after exposure to usual and routinely prolonged voice use from teachers with over 4 years of experience in teaching. STUDY DESIGN: The study design is observational and transversal with quantitative and descriptive evaluations. METHODS: A total of 28 female teachers were subjected to the Screening Index for Voice Disorder (SIVD) and to recordings of the sustained vowel /a/ before and after exposure to prolonged voice use...
June 20, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28645236/a-quantitative-study-of-empathy-in-pakistani-medical-students-a-multicentered-approach
#14
Nabia Tariq, Tariq Rasheed, Mohsen Tavakol
OBJECTIVE: To examine the empathy level of undergraduate medical students in Pakistan. Three hypotheses are developed based on the literature review. (1) Female medical students have a higher level of empathy than do male students. (2) Empathy scores vary during the medical school years in Pakistani students. (3) Medical students interested in people-oriented specialties would score higher than the students interested in technology-oriented specialties. METHODS: This is a quantitative inquiry approach using a cross-sectional design of 1453 students from 8 Pakistani medical schools, both private and state...
June 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/28645145/systematic-procedures-to-promote-u-s-hiv-medication-adherence-via-photovoice
#15
Michelle Teti, Victoria Shaffer, Wilson Majee, Rose Farnan, Mary Gerkovich
Medication adherence is essential to promote the health of people living with HIV (PL-HIV) and prevent HIV transmission in the U.S. Novel medication health promotion interventions are needed that address patient-centeredness, understandability, and communication with providers. The aims of this article are to define the systematic stages we used to develop an effective health promotion intervention via the products (e.g. images and stories) of Photovoice. We designed an intervention to improve HIV adherence knowledge, attitudes, and communication with providers through Photovoice...
June 21, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28644923/examining-transfer-effects-of-dual-task-training-protocols-for-a-complex-locomotor-task
#16
Timothy A Worden, Lori Ann Vallis
Training protocols designed to improve dual-task performance of an obstacle crossing and auditory Stroop task (OBS+Stroop) were tested. In Experiment  1 , following baseline collection of OBS+Stroop trials, proximally related walking training was performed, and participants were then retested on the OBS+Stroop test. After training, participants adopted a more cautious obstacle crossing strategy, indicating a potentially safer navigation strategy. Transfer effects from distally related training were then examined (Experiment  2 ); a computer game training paradigm was examined using the same testing protocol as Experiment  1 ...
June 23, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28644805/development-of-real-time-three-dimensional-photoacoustic-imaging-system-employing-spherically-curved-array-transducer
#17
Ryo Nagaoka, Takuya Tabata Ryo Takagi, Shin Yoshizawa, Shin-Ichiro Umemura, Yoshifumi Saijo
Photoacoustic imaging is a promising imaging modality to visualize specific living tissues based on the light absorption coefficients without dyeing. In this study, a real-time PA imaging system with a tunable laser was newly developed with an originally designed spherically curved array transducer. Five different series of experiments were conducted to validate the PA measurement system. The peak frequency of the transducer response was 17.7 MHz, and a volume-imaging rate of 3D volume imaging was 10 - 20 volumes per second...
June 21, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28644758/an-independent-shopping-experience-for-wheelchair-users-through-augmented-reality-and-rfid
#18
Zulqarnain Rashid, Rafael Pous, Christopher S Norrie
People with physical and mobility impairments continue to struggle to attain independence in the performance of routine activities and tasks. For example, browsing in a store and interacting with products located beyond an arm's length may be impossible without the enabling intervention of a human assistant. This research article describes a study undertaken to design, develop, and evaluate potential interaction methods for motor-impaired individuals, specifically those who use wheelchairs. Our study includes a user-centered approach, and a categorization of wheelchair users based upon the severity of their disability and their individual needs...
June 23, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28644688/intraosseous-administration-of-antidotes-a-systematic-review
#19
Audrée Elliott, Pierre-André Dubé, Amélie Cossette-Côté, Laura Patakfalvi, Eric Villeneuve, Martin Morris, Sophie Gosselin
CONTEXT: Intraosseous (IO) access is an established route of administration in resuscitation situations. Patients with serious poisoning presenting to the emergency department may require urgent antidote therapy. However, intravenous (IV) access is not always readily available. OBJECTIVE: This study reviews the current evidence for IO administration of antidotes that could be used in poisoning. The primary outcome was mortality as a surrogate of efficacy. Secondary outcomes included hemodynamic variables, electrocardiographic variables, neurological status, pharmacokinetics outcomes, and adverse effects as defined by each article...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28644679/success-of-university-student-volunteers-in-obtaining-consent-for-reviewing-private-health-information-for-emergency-research
#20
Adam I Kramer, Elizabeth Stephenson, Adam Betel, Johanna Crudden, Kathy Boutis
OBJECTIVES: This study aimed to determine the success of university student volunteers in obtaining consent from parents to allow review of their child's personal health information (PHI) for emergency research screening. This study also aimed to examine the variables associated with successful consent. METHODS: This was a prospective cross-sectional study conducted at a pediatric emergency department (ED). University students, who functioned as delegates of the health information custodian, approached parents for consent...
June 23, 2017: Accountability in Research
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