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https://www.readbyqxmd.com/read/29236035/short-communication-a-comparison-of-the-in-vitro-angiotensin-1-converting-enzyme-inhibitory-capacity-of-dairy-and-plant-protein-supplements
#1
Carlotta Giromini, Ágnes A Fekete, D Ian Givens, Antonella Baldi, Julie A Lovegrove
The consumption of supplements based on dairy or plant proteins may be associated with bioactive potential, including angiotensin-1-converting enzyme inhibitory (ACE-1i) activity, which is linked with blood pressure reduction in vivo. To gain insight into this proposed mechanism, the ACE-1i potential of protein-based supplements, including a selection of dairy (n = 10) and plant (n = 5) proteins were in vitro digested. The total digest was filtered and permeate and retentate were obtained. ACE-1i activity was measured as the ability of proteins (pre-digestion, 'gastric', permeate, and retentate) to decrease the hydrolysis of furanacroloyl-Phe-Glu-Glu (FAPGG) substrate for the ACE-1 enzyme...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29235345/mucus-and-cell-penetrating-nanoparticles-embedded-in-nano-into-micro-formulations-for-pulmonary-delivery-of-ivacaftor-in-cystic-fibrosis
#2
Barbara Porsio, Emanuela Fabiola Craparo, Nicolò Mauro, Gaetano Giammona, Gennara Cavallaro
Here, mucus-penetrating nanoparticles for pulmonary administration of Ivacaftor in patients with cystic fibrosis (CF) were produced with the dual aim to enhance Ivacaftor delivery to the airway epithelial cells, by a rapid diffusion through the mucus barrier and, at the same time, promote Ivacaftor lung cellular uptake. Pegylated and Tat-decorated Fluorescent Nanoparticles (FNPs) were produced by nanoprecipitation, starting by two synthetic copolymers and showed nanometric sizes (~70 nm), slightly negative ζ potential and high cytocompatibility towards human bronchial epithelium cells...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235181/fuzheng-huayu-capsule-as-an-adjuvant-treatment-for-hbv-related-cirrhosis-a-systematic-review-and-meta-analysis
#3
REVIEW
Tao Wang, Xuelin Zhou, Honghong Liu, Jiabo Wang, Ping Zhang, Yun Zhu, Kun Li, Shizhang Wei, Haotian Li, Lifu Wang, Ruilin Wang, Yanling Zhao
Fuzheng Huayu (FZHY) capsule, a formulated traditional Chinese medicine product with 6 Chinese herbs, is widely used for HBV-related cirrhosis as an adjuvant treatment. However, the efficacy of FZHY capsule for HBV-induced cirrhosis did not be comprehensively proved by systematic analysis. Our current analysis was aimed to assess the efficacy and safety of FZHY capsule by an evidence-based method. Databases, including China National Knowledge Infrastructure, Wangfang, VIP medicine information system, Pubmed, Embase, and Cochrane Library, were searched, and the randomized controlled trials of FZHY capsule were used for the treatment of HBV-associated liver cirrhosis...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29233216/nucleic-acids-function-and-potential-for-abiogenesis
#4
Falk Wachowius, James Attwater, Philipp Holliger
The emergence of functional cooperation between the three main classes of biomolecules - nucleic acids, peptides and lipids - defines life at the molecular level. However, how such mutually interdependent molecular systems emerged from prebiotic chemistry remains a mystery. A key hypothesis, formulated by Crick, Orgel and Woese over 40 year ago, posits that early life must have been simpler. Specifically, it proposed that an early primordial biology lacked proteins and DNA but instead relied on RNA as the key biopolymer responsible not just for genetic information storage and propagation, but also for catalysis, i...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/29233032/the-impact-of-laboratory-chow-for-rats-in-the-experiments-chemical-and-biological-evaluation-of-nine-grain-based-diet-options
#5
R S Ferreira, L de Souza Morelini, Emc de Azeredo, Ecs Vieira, E B Ferreira, Vsn da Silva, O L Tavano, L Azevedo
Cereal-based diets formulated as semi-purified diets can provide flexibility for researchers, enabling open controlled formulas, besides being cheaper than purified diets. Seeking to widen the researchers' options in their experimental design developments, we aimed at assaying the chemical score, growth performance and protein utilization of nine semi-purified experimental chows. These diets were formulated at 17.8%, 12% and 8% protein contents, using three variations of ingredients for each one, as follows: casein (C), casein+soybean meal (C+S, 1:1 w/w protein) and casein+soybean meal+corn gluten meal (C+S+G, 1:1:1 w/w protein), without cysteine supplementation and setting casein 17...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29231284/the-science-behind-skin-care-cleansers
#6
REVIEW
Zoe Diana Draelos
Two of the most important skin care categories with profound dermatologic implications are cleansers and moisturizers. Cleansers are composed of alkaline soaps or the less barrier-damaging synthetic detergents, known as syndets. The lower skin irritation and dryness found with syndets are related to their reduced tendency to cause protein denaturation due to the charge density of protein-bound micelle-like surfactant aggregates. Many cleansing formulations are available for purchase to meet hygiene needs varying by sex, age, ethnicity, occupation, environment, personal preferences, and the presence or absence of skin disease...
December 12, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29231176/tensorcalculator-exploring-the-evolution-of-mechanical-stress-in-the-ccmv-capsid
#7
Olga Kononova, Farkhad Maksudov, Kenneth A Marx, Valeri Barsegov
A new computational methodology for accurate numerical calculation of the Cauchy stress tensor, stress invariants, principal stress components, von Mises and Tresca tensors is developed. The methodology is based on the atomic stress approach which permits the calculation of stress tensors, widely used in continuum mechanics modeling of materials properties, using the output from the MD simulations of discrete atomic and Cα-based coarse-grained structural models of biological particles. The methodology mapped into software package TensorCalculator was successfully applied to the empty Cowpea Chlorotic Mottle virus (CCMV) shell to explore the evolution of mechanical stress in this mechanically-tested specific example of a soft virus capsid...
December 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29231157/plant-produced-subunit-vaccine-candidates-against-yellow-fever-induce-virus-neutralizing-antibodies-and-confer-protection-against-viral-challenge-in-animal-models
#8
Stephen Tottey, Yoko Shoji, R Mark Jones, Jessica A Chichester, Brian J Green, Konstantin Musiychuk, Huaxin Si, Slobodanka Manceva, Amy Rhee, Moneim Shamloul, Joey Norikane, Rosane C Guimarães, Elena Caride, Andrea N M R Silva, Marisol Simões, Patricia C C Neves, Renato Marchevsky, Marcos S Freire, Stephen J Streatfield, Vidadi Yusibov
Yellow fever (YF) is a viral disease transmitted by mosquitoes and endemic mostly in South America and Africa with 20-50% fatality. All current licensed YF vaccines, including YF-Vax® (Sanofi-Pasteur, France) and 17DD-YFV (Bio-Manguinhos, Brazil), are based on live attenuated virus produced in hens' eggs and have been widely used. The YF vaccines are considered safe and highly effective. However, a recent increase in demand for YF vaccines and reports of rare cases of YF vaccine-associated fatal adverse events have provoked interest in developing a safer YF vaccine that can be easily scaled up to meet this increased global demand...
December 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29231058/efaverinz-and-nano-gold-loaded-mannosylated-niosomes-a-host-cell-targeted-topical-hiv-1-prophylaxis-via-thermogel-system
#9
Tanushree Malik, Gaurav Chauhan, Goutam Rath, Rohan N Kesarkar, Abhay S Chowdhary, Amit K Goyal
Sexual dissemination of Human Immunodeficiency Virus-1 (HIV-1) is the prime mode of its spread. Topical microbicidal approach has gained much attention, but no real success is observed till date, either due to toxicity or resistance of active moieties and the lack of efficient drug delivery approaches. In this research protocol, a unique combination approach of a standard drug moiety, that is, Efaverinz (EFV) and a nanometal, that is, gold nanoparticles (GNPs) was tried. Both these candidates were delivered through a mannosylated niosomal system, to exploit protein (lectins present on HIV host cells) - carbohydrate (oligosaccharides such as mannan present on HIV gp-120 receptor) interaction...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29230197/exosome-mediated-genetic-information-transfer-a-missing-piece-of-osteoblast-osteoclast-communication-puzzle
#10
Pengbin Yin, Houchen Lv, Yi Li, Yuan Deng, Licheng Zhang, Peifu Tang
The skeletal system functions and maintains itself based on communication between cells of diverse origins, especially between osteoblasts (OBs) and osteoclasts (OCs), accounting for bone formation and resorption, respectively. Previously, protein-level information exchange has been the research focus, and this has been discussed in detail. The regulative effects of microRNAs (miRNAs) on OB and OC ignite the question as to whether genetic information could be transferred between bone cells. Exosomes, extracellular membrane vesicles 30-100 nm in diameter, have recently been demonstrated to transfer functional proteins, mRNAs, and miRNAs, and serve as mediators of intercellular communication...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29229936/identification-of-a-gene-signature-for-discriminating-metastatic-from-primary-melanoma-using-a-molecular-interaction-network-approach
#11
Rahul Metri, Abhilash Mohan, Jérémie Nsengimana, Joanna Pozniak, Carmen Molina-Paris, Julia Newton-Bishop, David Bishop, Nagasuma Chandra
Understanding the biological factors that are characteristic of metastasis in melanoma remains a key approach to improving treatment. In this study, we seek to identify a gene signature of metastatic melanoma. We configured a new network-based computational pipeline, combined with a machine learning method, to mine publicly available transcriptomic data from melanoma patient samples. Our method is unbiased and scans a genome-wide protein-protein interaction network using a novel formulation for network scoring...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229512/efficiency-of-resveratrol-loaded-sericin-nanoparticles-promising-bionanocarriers-for-drug-delivery
#12
Kunat Suktham, Thongchai Koobkobkruad, Tuksadon Wutikhun, Suvimol Surassmo
Sericin protein nanoparticles are a biocompatible, bio-viable class of nanocarriers gaining prominence in drug delivery system. This research aimed to investigate the suitability fabrication of silk protein (SP) nanoparticles for loading with resveratrol (RSV) via a solventless precipitation technique. The addition of 0.5% (w/v) pluronic surfactant proved optimal for SP nanoparticle fabrication, with obtained nanoparticles being spherical, mono-dispersed and having mean size of approximately 200-400 nm. All exhibited negative surface charges, the extent of which being dependent on the SP concentration, and were non-toxic to normal skin fibroblasts (CRL-2522)...
December 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29229294/impact-of-dha-intake-in-a-mouse-model-of-synucleinopathy
#13
Katherine Coulombe, Olivier Kerdiles, Cyntia Tremblay, Vincent Emond, Manon Lebel, Anne-Sophie Boulianne, Mélanie Plourde, Francesca Cicchetti, Frédéric Calon
Polyunsaturated fatty acids omega-3 (n-3 PUFA), such as docosahexaenoic acid (DHA), have been shown to prevent, and partially reverse, neurotoxin-induced nigrostriatal denervation in animal models of Parkinson's disease (PD). However, the accumulation of α-synuclein (αSyn) in cerebral tissues is equally important to the pathophysiology. To determine whether DHA intake improves various aspects related to synucleinopathy, ninety male mice overexpressing human αSyn under the Thy-1 promoter (Thy1-αSyn) were fed one of three diets (specially formulated control, low n-3 PUFA or high DHA) and compared to non-transgenic C57/BL6 littermate mice exposed to a control diet...
December 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29227526/bioactive-peptides-derived-from-seaweed-protein-and-their-health-benefits-antihypertensive-antioxidant-and-antidiabetic-properties
#14
REVIEW
Habtamu Admassu, Mohammed Abdalbasit A Gasmalla, Ruijin Yang, Wei Zhao
Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein-derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29225598/innovative-approaches-for-immune-tolerance-to-factor-viii-in-the-treatment-of-hemophilia-a
#15
REVIEW
Alexandra Sherman, Moanaro Biswas, Roland W Herzog
Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein formulations available, the risk of developing anti-dug antibodies ("inhibitors") remains. Overall, 20-30% of patients with severe disease develop inhibitors. Current clinical immune tolerance induction protocols to eliminate inhibitors are not effective in all patients, and there are no prophylactic protocols to prevent the immune response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29224339/immobilization-of-aluminum-hydroxide-particles-on-quartz-crystal-microbalance-sensors-to-elucidate-antigen-adjuvant-interaction-mechanisms-in-vaccines
#16
Jean-François Art, Aurélien Vander Straeten, Christine C Dupont-Gillain
Aluminum hydroxide (AH) salts are the most widely used adjuvants in vaccine formulation. They trigger immunogenicity from antigenic subunits that would otherwise suffer from a lack of efficiency. Previous studies focusing on antigen-AH interaction mechanisms, performed with model proteins, suggested that electrostatic interactions and phosphate-hydroxyl ligand exchanges drive protein adsorption on AH. We however recently evidenced that NaCl, used in vaccine formulation, provokes AH particle aggregation. This must be taken into account to interpret data related to protein adsorption on AH...
December 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29224098/role-of-estrogens-in-the-regulation-of-liver-lipid-metabolism
#17
Brian T Palmisano, Lin Zhu, John M Stafford
Before menopause, women are protected from atherosclerotic heart disease associated with obesity relative to men. Sex hormones have been proposed as a mechanism that differentiates this risk. In this review, we discuss the literature around how the endogenous sex hormones and hormone treatment approaches after menopause regulate fatty acid, triglyceride, and cholesterol metabolism to influence cardiovascular risk.The important regulatory functions of estrogen signaling pathways with regard to lipid metabolism have been in part obscured by clinical trials with hormone treatment of women after menopause, due to different formulations, routes of delivery, and pairings with progestins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223178/relative-influence-of-dietary-protein-and-energy-contents-on-lysine-requirements-and-voluntary-feed-intake-of-rainbow-trout-fry
#18
Mélusine Van Larebeke, Guillaume Dockx, Yvan Larondelle, Xavier Rollin
The effect of dietary digestible protein (DP) and/or digestible energy (DE) levels on lysine (Lys) requirements, Lys utilisation efficiency and voluntary feed intake (VFI) were studied in rainbow trout fry when Lys was the first limiting indispensable amino acid or in excess in the diet. Two trials were conducted at 11·6°C with eighty-one experimental diets, containing 280 g DP/kg DM (low protein (LP), trial 1), 600 g DP/kg DM (high protein (HP), trial 1) or 440 g DP/kg DM (medium protein (MP), trial 2), 17 MJ DE/kg (low energy (LE)), 19·5 MJ DE/kg (medium energy (ME)) or 22 MJ DE/kg (high energy (HE)), and nine Lys levels from deeply deficient to large excess (2·3-36 g/kg DM)...
December 10, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29222231/al-amyloidosis-from-molecular-mechanisms-to-targeted-therapies
#19
REVIEW
Giampaolo Merlini
Systemic amyloidosis is caused by misfolding and extracellular deposition of circulating proteins as amyloid fibrils, resulting in the dysfunction of vital organs. The most common systemic amyloidosis, light-chain (AL) amyloidosis, is caused by misfolded light chains produced by a small, dangerous B-cell clone. The process of amyloid formation, organ targeting, and damage is multifaceted and, after disease initiation, the complexity of the downstream pathogenic cascade increases, rendering its control a challenge...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29219064/natural-product-formulations-for-prevention-and-treatment-of-alzheimer-s-disease-a-patent-review
#20
Rumiana Koynova, Boris Tenchov
INTRODUCTION: Although considerable efforts have been made to develop effective therapeutic agents for Alzheimer's disease (AD), neither a consensus concerning the pathogenesis of the disease nor a successful therapy for its treatment is available. The natural product chemistry brings tremendous diversity and abundant resource for medical needs. OBJECTIVES: The present review summarizes recent patents on natural extracts and derived drugs as agents for prevention and treatment of AD...
December 7, 2017: Recent Patents on Drug Delivery & Formulation
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