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https://www.readbyqxmd.com/read/29217325/protocatechuic-acid-pca-induced-a-better-antiviral-effect-by-immune-enhancement-in-spf-chickens
#1
Yongxia Guo, Qiang Zhang, Zonghui Zuo, Jun Chu, Hongzhi Xiao, M Tariq Javed, Cheng He
Protocatechuic acid (PCA) is an antiviral agent against Avian Influenza virus (AIV) and Infectious Bursal Disease (IBD) virus but its antiviral mechanism is unknown. In this study, we evaluated the humoral and cellular responses to PCA in specific pathogen-free (SPF) chickens. One hundred forty 35-day-old SPF chickens were randomly divided into 7 groups. The birds were inoculated with the commercial, attenuated Newcastle Disease Virus (NDV) vaccine and then received orally with 10, 20 or 40 mg/kg body weight of PCA for 21 days...
December 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29217160/interaction-between-gallic-acid-and-asparaginase-to-potentiate-anti-proliferative-effect-on-lymphoblastic-leukemia-cell-line
#2
Zahra Sourani, Hedayatollah Shirzad, Moein Shirzad, Batoul Pourgheysari
BACKGROUND: Treatment of acute lymphoblastic leukemia (ALL) fails in some cases and the side effects cause mortality in certain patients. Gallic acid (GA), a polyhydroxyphenolic compound has biological functions including anti-proliferative properties. The aim of the present study was to investigate the growth inhibition effects of GA in combination with asparaginase (ASP), as a component of combination chemotherapy, in a lymphoblastic leukemia cell line. METHODS: Jurkat cells were incubated with different concentrations of GA with or without ASP...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29216400/activity-and-safety-of-crizotinib-in-patients-with-alveolar-soft-part-sarcoma-with-rearrangement-of-tfe3-european-organization-for-research-and-treatment-of-cancer-eortc-phase-2-trial-90101-create
#3
P Schöffski, A Wozniak, B Kasper, S Aamdal, M G Leahy, P Rutkowski, S Bauer, H Gelderblom, A Italiano, L H Lindner, I Hennig, S Strauss, B Zakotnik, A Anthoney, L Albiges, J-Y Blay, P Reichardt, J Sufliarsky, W T A van der Graaf, M Debiec-Rychter, R Sciot, T Van Cann, S Marréaud, T Raveloarivahy, S Collette, S Stacchiotti
Background: Alveolar soft part sarcoma(ASPS) is an orphan malignancy associated with a rearrangement of transcription factor E3(TFE3), leading to abnormal MET gene expression. We prospectively assessed the efficacy and safety of the tyrosine kinase inhibitor(TKI) crizotinib in patients with advanced or metastatic ASPS. Patients and methods: Eligible patients with reference pathology-confirmed ASPS received oral crizotinib 250 mg twice daily. By assessing the presence or absence of a TFE3 rearrangement, patients were attributed to MET+ and MET- sub-cohorts...
December 5, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29215330/quantifying-hospital-acquired-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-patients-in-dutch-hospitals
#4
Marjolein F Q Kluytmans-van den Bergh, Suzan P van Mens, Manon R Haverkate, Martin C J Bootsma, Jan A J W Kluytmans, Marc J M Bonten
BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Dutch hospitals from 2011 through 2014 and (2) the R-GNOSIS study, for which data were limited to those collected in a Dutch hospital in 2014...
December 7, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29214088/advanced-alveolar-soft-part-sarcoma-treated-with-pazopanib-over-three-years
#5
Yoji Shido, Yukihiro Matsuyama
Alveolar soft part sarcoma (ASPS) is a rare malignant tumor that generally occurs in adolescents and young adults. It progresses slowly, but lung and brain metastases often occur in the early phase of the clinical course, and chemotherapy has been reported as not being effective for ASPS. Pazopanib is a multitargeted tyrosine kinase inhibitor that has been clinically available from November 2012 in Japan. This is a case report of a patient presented with multiple lung metastases and unresectable primary abdominal ASPS...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29209986/data-on-single-nucleotide-polymorphism-of-dna-repair-genes-and-breast-cancer-risk-from-poland
#6
Beata Smolarz, Magdalena Bryś, Ewa Forma, Marek Zadrożny, Jan Bieńkiewicz, Hanna Romanowicz
Single nucleotide polymorphisms (SNPs) may modify the risk of cancer. They may be then regarded as potential markers of carcinogenesis. The aim of this study was to analyze the frequency of genotypes and alleles of SNPs in DNA repair genes and to investigate the influence this genetic variation exerts on breast cancer in Polish females. The test group comprised 600 females with breast cancer and 600 healthy controls. Genomic DNA was isolated and the SNPs in DNA repair genes were determined by High-Resolution Melter (HRM) technique...
December 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29207652/iqca-tavv-to-explore-the-effect-of-p-selectin-gpiib-iiia-il-2-il-6-and-il-8-on-deep-venous-thrombosis
#7
Jianhui Wu, Haimei Zhu, Guodong Yang, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao, Shiqi Peng
Deep vein thrombosis (DVT) associates with considerable morbidity, functional disability and mortality. Due to the lack of suitable inhibitor the correlation of various factors in DVT onset remains unknown. In this context we analyzed the structure of anti-platelet aggregation agent, P-selectin down-regulator, GPIIb/IIIa down-regulator and anti-inflammatory agent, thereby designed N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)- Thr-Ala-Arg-Gly-Asp(Val)-Val (IQCA-TAVV) as an inhibitor of DVT to receive evaluations...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207293/inhibition-of-apoptosis-by-caspase-inhibitor-z-vad-fmk-improves-cryotolerance-of-in%C3%A2-vitro-derived-bovine-embryos
#8
Maria Elena Pero, Gianluigi Zullo, Luigi Esposito, Alessandra Iannuzzi, Pietro Lombardi, Carolina De Canditiis, Gianluca Neglia, Bianca Gasparrini
The aim of this work was to evaluate whether the treatment with the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) during cryopreservation and post-warming in vitro culture improves cryotolerance of bovine in vitro produced (IVP) embryos. Abattoir derived bovine oocytes were in vitro matured, fertilized and cultured according to standard procedure. On Day 7, embryo yields were assessed and blastocysts randomly divided in 2 groups: vitrification and post-warming culture in the absence (n = 184) or presence (n = 156) of 20 μM Z-VAD-FMK...
December 2, 2017: Theriogenology
https://www.readbyqxmd.com/read/29203646/structural-and-biochemical-characterization-of-the-catalytic-domains-of-gdpp-reveals-a-unified-hydrolysis-mechanism-for-the-dhh-dhha1-phosphodiesterase
#9
Feng Wang, Qing He, Kaixuan Su, Tiandi Wei, Sujuan Xu, Lichuan Gu
The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final product is 5'-phosphadenylyl-adenosine (5'-pApA) or AMP. In previous study we revealed that Rv2837c, a stand-alone DHH/DHHA1 PDE, employs a 5'-pApA internal flipping mechanism to produce AMPs. However, why the membrane-bound DHH/DHHA1 PDE can only degrade c-di-AMP to 5'-pApA remains obscure...
December 4, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29203459/mobile-phone-apps-for-quality-of-life-and-well-being-assessment-in-breast-and-prostate-cancer-patients-systematic-review
#10
REVIEW
Esther Rincon, Francisco Monteiro-Guerra, Octavio Rivera-Romero, Enrique Dorronzoro-Zubiete, Carlos Luis Sanchez-Bocanegra, Elia Gabarron
BACKGROUND: Mobile phone health apps are increasingly gaining attention in oncological care as potential tools for supporting cancer patients. Although the number of publications and health apps focusing on cancer is increasing, there are still few specifically designed for the most prevalent cancers diagnosed: breast and prostate cancers. There is a need to review the effect of these apps on breast and prostate cancer patients' quality of life (QoL) and well-being. OBJECTIVE: The purposes of this study were to review the scientific literature on mobile phone apps targeting breast or prostate cancer patients and involving QoL and well-being (anxiety and depression symptoms) and analyze the clinical and technological characteristics, strengths, and weaknesses of these apps, as well as patients' user experience with them...
December 4, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29203165/sex-hormone-levels-in-the-brain-of-d-aspartate-treated-rats
#11
Maria Maddalena Di Fiore, Alessandra Santillo, Sara Falvo, Gabriella Chieffi Baccari, Massimo Venditti, Federica Di Giacomo Russo, Monica Lispi, Antimo D'Aniello
d-Aspartate (d-Asp) is an endogenous amino acid present in the central nervous system and endocrine glands of various animal taxa. d-Asp is implicated in neurotransmission, physiology of learning, and memory processes. In gonads, it plays a crucial role in sex hormone synthesis. We have investigated the effects of chronic (30 days d-Asp drinking solution) and acute (i.p. injection of 2μmol/g bw d-Asp) treatments on sex steroid synthesis in rat brain. Furthermore, to verify the direct effect of d-Asp on neurosteroidogenic enzyme activities, brain homogenates were incubated with different substrates (cholesterol, progesterone, or testosterone) with or without the addition of d-Asp...
December 1, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29202131/multifunctional-system-for-observing-measuring-and-analyzing-stimulation-evoked-neurochemical-signaling
#12
Christopher J Kimble, Joshua B Boesche, Diane R Eaker, Kenneth R Kressin, James K Trevathan, Seungleal Paek, Anders J Asp, Malcolm B McIntosh, J Luis Lujan
The ability to measure neurotransmitter activity using implanted electrochemical sensors offers researchers a potent technique for analyzing neural activity across specific neural circuitry. We have developed a wirelessly controlled device, WINCS Harmoni, to observe and measure neurotransmitter dynamics at up to four separate sensors, with high temporal and spatial resolution. WINCS Harmoni also incorporates a versatile neurostimulator that can be synchronized with electrochemical recording. The WINCS Harmoni platform is thus optimally suited for probing the neurochemical effects of neurostimulation, and may in turn enable the development of personalized therapies for multiple brain disorders...
May 2017: IEEE International Symposium on Medical Measurements and Applications: Proceedings
https://www.readbyqxmd.com/read/29196663/a-ser75-to-asp-phospho-mimicking-mutation-in-src-accelerates-ageing-related-loss-of-retinal-ganglion-cells-in-mice
#13
Kenji Kashiwagi, Sadahiro Ito, Shuichiro Maeda, Goro Kato
Src knockout mice show no detectable abnormalities in central nervous system (CNS) post-mitotic neurons, likely reflecting functional compensation by other Src family kinases. Cdk1- or Cdk5-dependent Ser75 phosphorylation in the amino-terminal Unique domain of Src, which shares no homology with other Src family kinases, regulates the stability of active Src. To clarify the roles of Src Ser75 phosphorylation in CNS neurons, we established two types of mutant mice with mutations in Src: phospho-mimicking Ser75Asp (SD) and non-phosphorylatable Ser75Ala (SA)...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196602/identification-and-characterization-of-a-core-fucosidase-from-the-bacterium-elizabethkingia-meningoseptica
#14
Tiansheng Li, Mengjie Li, Linlin Hou, Yameng Guo, Lei Wang, Guiqin Sun, Li Chen
All reported α-L-fucosidases catalyze the removal of nonreducing terminal L-fucoses from oligosaccharides or their conjugates, while having no capacity to hydrolyze core fucoses in glycoproteins directly. Here, we identified an α-fucosidase from the bacterium Elizabethkingia meningoseptica with catalytic activity against core α-1,3-fucosylated substrates and named it core fucosidase I (cFase I). Using site-specific mutational analysis, we found that three acidic residues (Asp-242, Glu-302, and Glu-315) in the predicted active pocket are critical for cFase I activity, with Asp-242 and Glu-315 acting as a pair of classic nucleophile and acid/base residues and Glu-302 acting in an as yet undefined role...
December 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29196181/cyclopeptide-dmt-d-lys-p-cf3-phe-phe-asp-nh2-a-novel-g-protein-biased-agonist-of-the-mu-opioid-receptor
#15
Justyna Piekielna-Ciesielska, Federica Ferrari, Girolamo Calo', Anna Janecka
Opioid peptides and alkaloid drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor which belongs to the G protein-coupled receptor (GPCR) family. A new important pharmacological concept in the field of GPCRs is biased agonism. Two mu receptor ligands, Dmt-c[D-Lys-Phe-Phe-Asp]NH2 (C-36) and Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2 (F-81), were evaluated in terms of their ability to promote or block mu receptor/G protein and mu receptor/β-arrestin interactions...
November 28, 2017: Peptides
https://www.readbyqxmd.com/read/29195986/comparison-of-non-volatile-umami-components-in-chicken-soup-and-chicken-enzymatic-hydrolysate
#16
Yan Kong, Xiao Yang, Qi Ding, Yu-Yu Zhang, Bao-Guo Sun, Hai-Tao Chen, Ying Sun
Umami taste is an important part to the taste of chicken. To isolate and identify non-volatile umami compounds, fractions from chicken soup and hydrolysate were prepared and analyzed. Amino acids were analyzed by amino acid analyzer. Organic acids and nucleotides were determined by ultra-performance liquid chromatography. Separation procedures utilizing ultrafiltration, Sephadex G-15 and reversed-phase high-performance liquid chromatography were used to isolate umami taste peptides. Combined with sensory evaluation and LC-Q-TOF-MS, the amino acid sequences of 12 oligopeptides were determined...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29195972/impact-of-phenylalanine-and-urea-applications-to-tempranillo-and-monastrell-vineyards-on-grape-amino-acid-content-during-two-consecutive-vintages
#17
Teresa Garde-Cerdán, Gastón Gutiérrez-Gamboa, Javier Portu, José Ignacio Fernández-Fernández, Rocío Gil-Muñoz
Nitrogen plays a key role in the fermentation and secondary metabolites formation. The aim was to study the influence of vine nitrogen applications on grape amino acid composition. Nitrogen sources applied to Tempranillo and Monastrell grapevines were phenylalanine and urea, during two seasons. Results showed that the application of these compounds had little effect on grape amino acid composition, regardless of variety and vintage. This could be due to the fact that vineyards did not present nitrogenous requirements...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29195955/new-insights-in-integrated-response-mechanism-of-lactobacillus-plantarum-under-excessive-manganese-stress
#18
Yanjun Tong, Qixiao Zhai, Wenwei Lu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen
As a natural inhabitant of gastrointestinal tract, Lactobacillus plantarum is well known for its health-promoting effects, especially in heavy metal-removal function. The response mechanism integrated physiology and proteomics of Lactobacillus plantarum under excessive manganese stress was systematically performed. More extracellular polymeric substance was secreted, whereas cells preferred to aggregate for resisting manganese stress. The stability of the membrane was maintained by up-regulating the proportion of unsaturated fatty acids, especially cyclopropane fatty acids...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29193371/differential-interaction-of-prmt1-with-rgg-boxes-of-the-fet-family-proteins-ews-and-taf15
#19
Kim K C Li, Bess L Chau, Kevin A W Lee
The FET sub-family (FUS/TLS, EWS, TAF15) of RNA-binding proteins have remarkably similar overall structure but diverse biological and pathological roles. The molecular basis for FET protein specialisation is largely unknown. Gly-Arg-Rich regions (RGG-boxes) within FET proteins are targets for methylation by Protein-Arginine-Methyl-Transferase-1 (PRMT1) and substrate capture is thought to involve electrostatic attraction between positively charged polyRGG substrates and negatively charged surface channels of PRMT1...
November 30, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29190843/practicing-medicine-in-1917-rhode-island
#20
Todd M Olszewski
Using editorials published in the Rhode Island Medical Journal's inaugural year, this article examines what it meant to practice medicine in Rhode Island in 1917. One hundred years ago, the state's medical community was undergoing rapid transformation epitomized by a turn toward the germ theory of disease, ongoing education and hospital reform, and a growing sense of the profession's political and social role. In many ways, the social and professional concerns of Rhode Island physicians in 1917 continue to resonate today...
December 1, 2017: Rhode Island Medical Journal
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