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ovarian cancer early diagnosis

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https://www.readbyqxmd.com/read/29298171/expression-of-%C3%AE-v-tubulin-in-secretory-cells-of-the-fallopian-tube-epithelium-marks-cellular-atypia
#1
Deepti Mathew, Yanhua Wang, Anne Van Arsdale, Susan Band Horwitz, Hayley McDaid
OBJECTIVES: Class V Beta tubulin isotype (βV-tubulin) was recently found to have tissue-specific expression patterns in epithelial tissues with secretory function and aberrant expression in tumors. The aims of this pilot study were (a) to examine expression of βV-tubulin in the fallopian tube epithelium (FTE) of patients who underwent salpingectomy, (b) to characterize FTE atypia in high-risk patients with BRCA mutations, and (c) to determine expression of βV-tubulin in serous ovarian neoplasms...
January 3, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29290193/spectrum-of-gynecological-malignancies-at-jamshoro
#2
Naheed Parveen, Raheel Sikander, Majida, Shaheen
OBJECTIVE: To describe the frequency and spectrum of different types of gynecological malignancies. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences, Jamshoro, from January 2014 to December 2015. METHODOLOGY: All patients with gynecological malignancies, admitted at the study place, whether previously diagnosed or need to establish the diagnosis on the basis of EUA, biopsy, staging and for surgery during the study period were included...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29281053/reported-incidence-and-survival-of-fallopian-tube-carcinomas-a-population-based-analysis-from-the-north-american-association-of-central-cancer-registries
#3
Britton Trabert, Sally B Coburn, Andrea Mariani, Hannah P Yang, Philip S Rosenberg, Gretchen L Gierach, Nicolas Wentzensen, Kathy A Cronin, Mark E Sherman
Background: Recognition that serous tubal intraepithelial carcinoma (STIC) may represent the first manifestation of many high-grade cancers that were once considered ovarian primary tumors has led to changes in diagnostic practices that could dramatically increase the reporting of tubal carcinomas in US population-based cancer registries. Further, increased detection of early-stage tubal carcinomas through increased recognition coupled with meticulous pathology processing protocols raises important unanswered questions about the clinical behavior of such lesions, which can only be answered using large data sets...
December 21, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29245346/two-independent-incidences-of-skin-metastases-in-the-umbilicus-and-abdominal-wall-in-ovarian-serous-adenocarcinoma-a-case-report-and-review-of-the-literature
#4
Hongyan Cheng, Chunmei Gao, Runtong Zhang, Zhaojie Yang, Guiyu Zhang
RATIONALE: Advanced ovarian cancer is usually associated with intra-abdominal metastases and while it commonly spreads directly to the omentum, intestine, liver, or other organs, it can also metastasize through the lymphatic channels and the hematogenous pathway. With an increasing number of invasive operations being performed with chemoradiotherapy, the incidence of extra-abdominal metastases has risen. Nevertheless, ovarian cancer with skin metastases is quite rare. PATIENT CONCERNS: We report a case of ovarian cancer with two independent incidences of skin metastases in the umbilicus and abdominal wall...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29205312/disparities-in-ovarian-cancer-survival-in-the-united-states-2001-2009-findings-from-the-concord-2-study
#5
Sherri L Stewart, Rhea Harewood, Melissa Matz, Sun Hee Rim, Susan A Sabatino, Kevin C Ward, Hannah K Weir
BACKGROUND: Ovarian cancer is the fifth leading cause of cancer death among women in the United States. This study reports ovarian cancer survival by state, race, and stage at diagnosis using data from the CONCORD-2 study, the largest and most geographically comprehensive, population-based survival study to date. METHODS: Data from women diagnosed with ovarian cancer between 2001 and 2009 from 37 states, covering 80% of the US population, were used in all analyses...
December 15, 2017: Cancer
https://www.readbyqxmd.com/read/29202783/influences-on-anticipated-time-to-ovarian-cancer-symptom-presentation-in-women-at-increased-risk-compared-to-population-risk-of-ovarian-cancer
#6
Stephanie Smits, Jacky Boivin, Usha Menon, Kate Brain
BACKGROUND: In the absence of routine ovarian cancer screening, promoting help-seeking in response to ovarian symptoms is a potential route to early diagnosis. The factors influencing women's anticipated time to presentation with potential ovarian cancer symptoms were examined. METHODS: Cross-sectional questionnaires were completed by a sample of women at increased familial risk (n = 283) and population risk (n = 1043) for ovarian cancer. Measures included demographic characteristics, symptom knowledge, anticipated time to symptom presentation, and health beliefs (perceived susceptibility, worry, perceived threat, confidence in symptom detection, benefits and barriers to presentation)...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29200893/epidemiology-of-ovarian-cancers-in-zaria-northern-nigeria-a-10-year-study
#7
Marliyya Sanusi Zayyan, Saad Aliyu Ahmed, Adekunle O Oguntayo, Abimbola O Kolawole, Tajudeen Ayodeji Olasinde
Background: Globally, the absence of a premalignant stage of ovarian cancer and a reliable screening tool make early diagnosis difficult. Locally, poverty, ignorance, and lack of organized cancer services make prognosis poor. We describe the epidemiological features of ovarian cancer seen at Ahmadu Bello University Teaching Hospital Zaria, Northern Nigeria, a tertiary referral center, over a 10-year period in this challenging setting. Methods: All cases of histologically diagnosed ovarian cancer between January 1, 2004 and December 31, 2013 were included in the study...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29188209/outcomes-in-20-gynecologic-cancer-patient-with-brain-metastasis-a-single-institution-retrospective-study
#8
Seung Bin Kim, Kihwan Hwang, Jin-Deok Joo, Jung Ho Han, Yong Beom Kim, Chae-Yong Kim
Background: The incidence of brain metastasis (BM) in gynecologic cancers has risen recently, due to prolonged survival times and an early diagnosis. We analyzed treatment outcomes of patients with BM from gynecologic cancers. Methods: Among 951 patients with BM who were treated in neurosurgical department from July 2003 to February 2016, a total of 20 (2%) patients were from gynecologic cancers. The patients' clinical characteristics were collected by using medical records...
October 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29184796/oncofertility-in-sarcoma-patients
#9
REVIEW
Diana M Lopategui, Raphael Yechieli, Ranjith Ramasamy
Treatment for sarcoma can significantly decrease fertility, both due to the irradiation of gonads, and the impact of chemotherapy on gametogenesis. Infertility in cancer survivors causes significant regret and decreased quality of life in their adulthood. As this cancer mainly affects children and young adults, fertility preservation is an essential part of survivorship care, however it remains one of the least implemented services in adolescent and young adult cancer patients. Success of fertility preservation is highly dependent on the referral prior to oncologic treatment...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29175263/missing-data-and-chance-variation-in-public-reporting-of-cancer-stage-at-diagnosis-cross-sectional-analysis-of-population-based-data-in-england
#10
Matthew E Barclay, Georgios Lyratzopoulos, David C Greenberg, Gary A Abel
BACKGROUND: The percentage of cancer patients diagnosed at an early stage is reported publicly for geographically-defined populations corresponding to healthcare commissioning organisations in England, and linked to pay-for-performance targets. Given that stage is incompletely recorded, we investigated the extent to which this indicator reflects underlying organisational differences rather than differences in stage completeness and chance variation. METHODS: We used population-based data on patients diagnosed with one of ten cancer sites in 2013 (bladder, breast, colorectal, endometrial, lung, ovarian, prostate, renal, NHL, and melanoma)...
November 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29156299/outcomes-from-ovarian-cancer-screening-in-the-plco-trial-histologic-heterogeneity-impacts-detection-overdiagnosis-and-survival
#11
Sarah M Temkin, Eric A Miller, Goli Samimi, Christine D Berg, Paul Pinsky, Lori Minasian
AIM: A mortality benefit from screening for ovarian cancer has never been demonstrated. The aim of this study was to evaluate the screening outcomes for different histologic subtypes of ovarian cancers. METHODS: Women in the screening arm of the Prostate, Lung, Colorectal and Ovarian Screening Trial underwent CA-125 and transvaginal ultrasound annually for 3-5 years. We compared screening test characteristics (including overdiagnosis) and outcomes by tumour type (type II versus other) and study arm (screening versus usual care)...
November 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29141850/autoantibodies-against-hsf1-and-ccdc155-as-biomarkers-of-early-stage-high-grade-serous-ovarian-cancer
#12
Amy L Wilson, Laura R Moffitt, Nadine Duffield, Adam Rainczuk, Tom W Jobling, Magdalena Plebanski, Andrew N Stephens
BACKGROUND: Tumor-directed circulating autoantibodies (AAbs) are a well-established feature of many solid tumor types, and are often observed prior to clinical disease manifestation. As such, they may provide a good indicator of early disease development. We have conducted a pilot study to identify novel AAbs as markers of early stage HGSOCs. METHODS: A rare cohort of patients with early (FIGO stage Ia-c) HGSOCs for IgG, IgA and IgM-mediated AAb reactivity using high content protein arrays (containing 9184 individual proteins)...
November 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29132396/circulating-cell-free-dna-and-circulating-tumor-cells-the-liquid-biopsies-in-ovarian-cancer
#13
REVIEW
Xianliang Cheng, Lei Zhang, Yajuan Chen, Chen Qing
Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs) emerging as "liquid biopsies". They represent non-invasive biomarkers and are viable, as they can be isolated from human plasma, serum and other body fluids. Molecular characterization of circulating tumor DNA (ct-DNA) and CTCs offer unique potentials to better understand the biology of metastasis and resistance to therapies...
November 13, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29131023/evaluation-of-serum-nidogen-2-as-a-screening-and-diagnostic-tool-for-ovarian-cancer
#14
Haitham A Torky, Ahmed Sherif, Ashraf Abo-Louz, Mohamed Ali, Ali Ahmed, Ahmad Ali
INTRODUCTION: Ovarian cancer is a relatively common occurrence with the formation of a tumour in the ovaries and is the leading cause of death in the gynecological field. Despite enormous efforts, there are no successful screening methods developed until now to decrease mortality in this regard. AIM: To evaluate nidogen-2 as a new tumour marker combined with higher sensitivity, specificity and accuracy than carbohydrate antigen (CA-125) and Doppler ultrasound to improve early diagnosis of ovarian cancer...
November 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29125478/utility-of-paraneoplastic-antigens-as-biomarkers-for-surveillance-and-prediction-of-recurrence-in-ovarian-cancer
#15
Madhumita Chatterjee, Laura C Hurley, Nancy K Levin, Matthew Stack, Michael A Tainsky
BACKGROUND: Ovarian cancer is frequently diagnosed at an advanced stage and 70% of patients experience recurrence months to years from initial diagnosis. The expression of paraneoplastic antigens can result in the occurrence of onconeural autoantibodies in ovarian cancer that may be associated with neurological disorders that are clinically manifested in patients before diagnosis of ovarian cancer. These paraneoplastic antigens can serve as excellent biomarkers not only for early detection but also for monitoring ovarian cancer recurrence...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29117576/the-utility-of-anti-m%C3%A3-llerian-hormone-in-the-diagnosis-and-prediction-of-loss-of-ovarian-function-following-chemotherapy-for-early-breast-cancer
#16
RANDOMIZED CONTROLLED TRIAL
R A Anderson, J Mansi, R E Coleman, D J A Adamson, R C F Leonard
AIM: Chemotherapy results in permanent loss of ovarian function in some premenopausal women. Accurate identification in women with hormone-sensitive early breast cancer (eBC) would allow optimisation of subsequent endocrine treatment. We sought to assess whether analysis of anti-Müllerian hormone (AMH) using a sensitive automated assay could identify women who would not regain ovarian function after chemotherapy. METHODS: Data from women in the Ovarian Protection Trial in Premenopausal Breast Cancer Patients (OPTION) trial of goserelin (a gonadotrophin-releasing hormone (GnRH) analogue) for ovarian protection were analysed...
December 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29100380/circulating-tumor-cells-in-the-differential-diagnosis-of-adnexal-masses
#17
Dong Hoon Suh, Miseon Kim, Jin Young Choi, Jiyoon Bu, Yoon-Tae Kang, Byung Su Kwon, Banghyun Lee, Kidong Kim, Jae Hong No, Yong-Beom Kim, Young-Ho Cho
The aim of this study was to evaluate circulating tumor cell (CTC) detection in the differential diagnosis of adnexal masses. A total of 87 preoperative women with an indeterminate adnexal mass were prospectively enrolled. Preoperative diagnostic modalities including CTC detection, risk of ovarian malignancy algorithm, risk of malignancy index, and computed tomography or magnetic resonance imaging were compared. Forty-three (49.4%) benign tumors, 13 (14.9%) borderline malignant masses, and 31 (35.7%) cancers were pathologically confirmed...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29071831/-screening-in-onco-gynecology-beneficial-for-all-patients
#18
Lorraine Grangier, Patrick Petignat, Manuela Undurraga Malinverno
Every day, 5 women are diagnosed with gynecological cancer in Switzerland. Prognosis of ovarian, endometrial and cervical cancer is dependent on early diagnosis. Cervical cancer mortality has decreased since the introduction of screening. Unfortunately, screening in ovarian and endometrial cancer has not shown the same results. On the contrary, patients screened for these cancers have an increased morbidity without any additional benefit of survival. This article presents a review of the clinical benefits and harms of gynecological cancer screening...
October 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29069951/familial-swyer-syndrome-a-rare-genetic-entity
#19
Manilal Banoth, Ramana Reddy Naru, Mohammed Basheeruddin Inamdar, Amit Kumar Chowhan
Swyer syndrome is a pure gonadal dysgenesis associated with a 46 XY karyotype and primary amenorrhea in a phenotypic female. Individuals in this syndrome are at an increased risk for development of gonadal malignancies. Swyer syndrome (gonadal dysgenesis) running in families is rare event and few such scenarios were reported in the literature. Here we are presenting this rare entity involving three affected siblings born to a non-consanguineous couple. Index case - A 23-year-old female with primary amenorrhea is presented with a mass per abdomen...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29036787/evaluation-of-serum-ccl18-as-a-potential-biomarker-for-ovarian-cancer
#20
Linjing Yuan, Jianxin Wan, Chumei Huang, Jingjing Liang, Min Liu, Caifeng Yue, Laisheng Li
BACKGROUND: Early detection and differentiation diagnosis of a pelvic mass (PM) is crucial in improving the prognosis of patients with epithelial ovarian cancer (EOC). C-C motif chemokine ligand 18 (CCL18) was reported as a chemokine-mediated tumor-related inflammation that can be detected in serum and may correlate with cancer patients' prognosis. OBJECTIVE: We performed this study to investigate the relationship between CCL18 levels and clinical characteristics of EOC patients, and to explore their diagnostic and prognostic values...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
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