keyword
MENU ▼
Read by QxMD icon Read
search

ovarian cancer pcos

keyword
https://www.readbyqxmd.com/read/27862853/lesbian-and-bisexual-women-s-gynaecological-conditions-a-systematic-review-and-exploratory-meta-analysis
#1
REVIEW
K Robinson, K Y Galloway, S Bewley, C Meads
BACKGROUND: Little is known about the gynaecological health of lesbian and bisexual (LB) women. OBJECTIVES: To examine differences in incidence and/or prevalence of gynaecological conditions in LB compared with heterosexual women. SEARCH STRATEGY: The systematic review protocol was prospectively registered (PROSPERO-CRD42015027091) and searches conducted in seven databases. SELECTION CRITERIA: Comparative studies published 2000-2015, reporting any benign (non-infectious) and/or malignant gynaecological conditions with no language or setting restrictions...
November 15, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27836688/pathologic-significance-of-set-i2pp2a-mediated-pp2a-and-non-pp2a-pathways-in-polycystic-ovary-syndrome-pcos
#2
REVIEW
Shi-Wen Jiang, Siliang Xu, Haibin Chen, Xiaoqiang Liu, Zuoqing Tang, Yugui Cui, Jiayin Liu
SET (SE translocation, SET), a constitutive inhibitor of protein phosphatase 2A (PP2A), is a multifunctional oncoprotein involved in DNA replication, histone modification, nucleosome assembly, gene transcription and cell proliferation. It is widely expressed in human tissues including the gonadal system and brain. Intensive studies have shown that overexpressed SET plays an important role in the development of Alzheimer's disease (AD), and may also contribute to the malignant transformation of breast and ovarian cancers...
November 9, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27821561/the-ovarian-renin-angiotensin-system-ovras-a-major-factor-in-ovarian-function-and-disease
#3
Angela Palumbo, Julio Ávila, Frederick Naftolin
This contribution summarizes the pivotal role of the ovarian renin-angiotensin system (OVRAS) in ovarian physiology and disease, with particular emphasis on human clinical implications and established translational applications. The presence of a complete OVRAS in all studied species has been known for decades. The OVRAS has major effects on follicle development/atresia and ovulation and steroid hormone secretion, that is, it is necessary for normal reproduction. It is well established that OVRAS activity is regulated by gonadotropins and depends on activation of proteases in the area of growing follicles...
December 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27817040/female-infertility-infertility-associated-diagnoses-and-comorbidities-a-review
#4
REVIEW
Brent Hanson, Erica Johnstone, Jessie Dorais, Bob Silver, C Matthew Peterson, James Hotaling
PURPOSE: The purpose of the study is to evaluate existing literature for possible associations between female infertility, infertility-associated diagnoses, and the following areas of disease: psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction. METHODS: The design of the study is a literature review. The patients were women included in 26 selected studies due to a diagnosis of infertility or a reproductive disorder associated with infertility...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27801385/a-review-of-metabolic-syndrome-research-in-malaysia
#5
K G Lim, W K Cheah
Seventy-three articles related to metabolic syndrome were found in a search through databases dedicated to indexing all literature with original data involving the Malaysian population between years 2000 and 2015. Metabolic syndrome affects 25 to 40% of adult population of Malaysia with the risk increasing with age. Obese children are also at risk. Indian ethnicity has the highest rates, followed by Malay and chinese. It was found that socioeconomics determinants such as living in urban areas, unemployment, lower income, lower education level and shift workers had higher prevalence of metabolic syndrome...
June 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27798047/common-diseases-as-determinants-of-menopausal-age
#6
Jingmei Li, Mikael Eriksson, Kamila Czene, Per Hall, Kenny A Rodriguez-Wallberg
STUDY QUESTION: Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER: Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY: It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively...
October 18, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27775603/zinc-finger-and-x-linked-factor-zfx-binds-to-human-set-transcript-2-promoter-and-transactivates-set-expression
#7
Siliang Xu, Ping Duan, Jinping Li, Tristan Senkowski, Fengbiao Guo, Haibin Chen, Alberto Romero, Yugui Cui, Jiayin Liu, Shi-Wen Jiang
SET (SE Translocation) protein carries out multiple functions including those for protein phosphatase 2A (PP2A) inhibition, histone modification, DNA repair, and gene regulation. SET overexpression has been detected in brain neurons of patients suffering Alzheimer's disease, follicle theca cells of Polycystic Ovary Syndrome (PCOS) patients, and ovarian cancer cells, indicating that SET may play a pathological role for these disorders. SET transcript 2, produced by a specific promoter, represents a major transcript variant in different cell types...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27725832/insulin-sensitizers-polycystic-ovary-syndrome-and-gynaecological-cancer-risk
#8
REVIEW
Rosa Lauretta, Giulia Lanzolla, Patrizia Vici, Luciano Mariani, Costanzo Moretti, Marialuisa Appetecchia
Preclinical, early phase clinical trials and epidemiological evidence support the potential role of insulin-sensitizers in cancer prevention and treatment. Insulin-sensitizers improve the metabolic and hormonal profile in PCOS patients and may also act as anticancer agents, especially in cancers associated with hyperinsulinemia and oestrogen dependent cancers. Several lines of evidence support the protection against cancer exerted by dietary inositol, in particular inositol hexaphosphate. Metformin, thiazolidinediones, and myoinositol postreceptor signaling may exhibit direct inhibitory effects on cancer cell growth...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27667654/long-and-irregular-menstrual-cycles-polycystic-ovary-syndrome-and-ovarian-cancer-risk-in-a-population-based-case-control-study
#9
H R Harris, L J Titus, D W Cramer, K L Terry
Long and irregular menstrual cycles, a hallmark of polycystic ovary syndrome (PCOS), have been associated with higher androgen and lower sex hormone binding globulin levels and this altered hormonal environment may increase the risk of specific histologic subtypes of ovarian cancer. We investigated whether menstrual cycle characteristics and self-reported PCOS were associated with ovarian cancer risk among 2,041 women with epithelial ovarian cancer and 2,100 controls in the New England Case-Control Study (1992-2008)...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27548360/ten-challenges-in-contraception
#10
Audrey Binette, Kerry Howatt, Ashley Waddington, Robert L Reid
Despite the introduction of promising products into the contraceptive market, the rate of unintended pregnancies remains high. Women with underlying medical conditions should have access to safe and effective contraceptive methods for various reasons, including the potential deleterious effect of the disease on the pregnancy or the effect of the pregnancy on the disease process. Healthcare providers are often confronted with cases in which contraception counseling is problematic due to controversial evidence and persistent myths...
August 22, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27514712/altered-steroid-metabolism-and-insulin-signaling-in-pcos-endometria-impact-in-tissue-function
#11
Lorena Oróstica, Carlos Rosas, Francisca Plaza-Parrochia, Isis Astorga, Fernando Gabler, Víctor García, Carmen Romero, Margarita Vega
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine/ metabolic disorder characterized by hyperandrogenemia and in most cases, by hyperinsulinemia in addition to obesity. Besides ovarian dysfunction, endometrial physiology is also disrupted since this tissue is highly dependent on the action of steroids; in case of conception cycles, high percentage of abortion is observed. Because of the endocrine/metabolic alterations, PCOS-women present high probability to develop hyperplasia and endometrial cancer, where an imbalance of cell proliferation/apoptosis processes is detected...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27510637/polycystic-ovary-syndrome
#12
Ricardo Azziz, Enrico Carmina, ZiJiang Chen, Andrea Dunaif, Joop S E Laven, Richard S Legro, Daria Lizneva, Barbara Natterson-Horowtiz, Helena J Teede, Bulent O Yildiz
Polycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM) - with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer...
2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27341345/molecular-signatures-of-ovarian-diseases-insights-from-network-medicine-perspective
#13
Medi Kori, Esra Gov, Kazim Yalcin Arga
Dysfunctions and disorders in the ovary lead to a host of diseases including ovarian cancer, ovarian endometriosis, and polycystic ovarian syndrome (PCOS). Understanding the molecular mechanisms behind ovarian diseases is a great challenge. In the present study, we performed a meta-analysis of transcriptome data for ovarian cancer, ovarian endometriosis, and PCOS, and integrated the information gained from statistical analysis with genome-scale biological networks (protein-protein interaction, transcriptional regulatory, and metabolic)...
August 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27218012/extrahepatic-manifestations-of-nonalcoholic-fatty-liver-disease
#14
Lisa B VanWagner, Mary E Rinella
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide with an increased prevalence of metabolic, macro- and microvascular complications. The primary causes of mortality in NAFLD are cardiovascular disease (CVD), malignancy and liver disease. NAFLD is a multisystem disease that affects a variety of extra-hepatic organ systems. The main focus of this review is to summarize the reported extra-hepatic associations, which include CVD, chronic kidney disease, obstructive sleep apnea, osteoporosis, psoriasis, colorectal cancer, iron overload and various endocrinopathies (e...
June 2016: Current Hepatology Reports
https://www.readbyqxmd.com/read/27182828/role-of-metformin-in-women-s-health-review-of-its-current-place-in-clinical-practice-and-emerging-indications-for-future
#15
Vikram Sinai Talaulikar, Thomas Tang, Ephia Yasmin
IMPORTANCE: Metformin, an oral antihyperglycemic drug, acts as an insulin sensitizer in the treatment of type 2 diabetes mellitus. It has also been widely used in the treatment of polycystic ovary syndrome (PCOS) and gestational diabetes mellitus. Although randomized clinical trials have failed to establish its superiority over other forms of treatment, metformin continues to be a treatment option in specific subgroups of women either alone or as an adjunct with other therapies in management of PCOS...
May 2016: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/27165625/what-threshold-values-of-antral-follicle-count-and-serum-amh-levels-should-be-considered-for-oocyte-cryopreservation-after-in-vitro-maturation
#16
C Sonigo, C Simon, M Boubaya, A Benoit, C Sifer, N Sermondade, M Grynberg
STUDY QUESTION: What threshold values of ultrasonographic antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) levels should be considered for ensuring the cryopreservation of sufficient number of in vitro matured (IVM) oocytes, in cancer patients seeking fertility preservation (FP)? SUMMARY ANSWER: AFC and serum AMH values >20 follicles and 3.7 ng/ml, respectively, are required for obtaining at least 10 IVM oocytes for cryopreservation. WHAT IS KNOWN ALREADY: IVM of cumulus oocyte complexes (COCs) followed by oocyte cryopreservation has emerged recently as an option for urgent FP...
July 2016: Human Reproduction
https://www.readbyqxmd.com/read/27156350/polycystic-ovary-syndrome-endometrial-markers
#17
Terhi T Piltonen
Women with polycystic ovarian syndrome (PCOS) present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS and an increased miscarriage rate have been suggested to coincide, but the results are conflicting. Recent studies have also shown increased risks of pregnancy-induced hypertension, preeclampsia, and premature delivery that may be related to altered decidualization/placentation in affected women. In the long run, PCOS per se is associated with the occurrence of endometrial cancer (EC), with obesity aggravating the risk...
April 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27142131/does-myo-inositol-effect-on-pcos-follicles-involve-cytoskeleton-regulation
#18
Mariano Bizzarri, Alessandra Cucina, Simona Dinicola, Abdel Halim Harrath, Saleh H Alwasel, Vittorio Unfer, Arturo Bevilacqua
Inositol metabolism is severely impaired in follicles obtained from cystic ovaries, leading to deregulated insulin transduction and steroid synthesis. On the contrary, inositol administration to women suffering from polycystic ovary syndrome (PCOS) has been proven to efficiently counteract most of the clinical hallmarks displayed by PCOS patients, including insulin resistance, hyperandrogenism and oligo-amenorrhea. We have recently observed that myo-inositol induces significant changes in cytoskeletal architecture of breast cancer cells, by modulating different biochemical pathways, eventually modulating the epithelial-mesenchymal transition...
June 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27109000/vascular-endothelial-growth-factor-induces-anti%C3%A2-m%C3%A3-llerian-hormone-receptor%C3%A2-2-overexpression-in-ovarian-granulosa-cells-of-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-patients
#19
Yanqiu Fang, Xiaodan Lu, Lei Liu, Xiuying Lin, Munan Sun, Jianhua Fu, Shufen Xu, Yan Tan
Misregulation of vascular endothelial growth factor A (VEGF‑A) has been implicated in numerous types of ovarian disease, such as polycystic ovarian syndrome, ovarian hyperstimulation syndrome, endometriosis and ovarian cancer. VEGF regulates blood vessel permeability and angiogenesis. In our previous study, VEGF‑regulated gene expression was profiled in the uterus of a transgenic mouse model with repressed VEGF expression, which indicated that VEGF is an important regulator in controlling gene expression in the uterus...
June 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27102646/circulating-micrornas-in-follicular-fluid-powerful-tools-to-explore-in-vitro-fertilization-process
#20
E Scalici, S Traver, T Mullet, N Molinari, A Ferrières, C Brunet, S Belloc, S Hamamah
Circulating or "extracellular" microRNAs (miRNAs) detected in biological fluids, could be used as potential diagnostic and prognostic biomarkers of several disease, such as cancer, gynecological and pregnancy disorders. However, their contributions in female infertility and in vitro fertilization (IVF) remain unknown. This study investigated the expression profiles of five circulating miRNAs (let-7b, miR-29a, miR-30a, miR-140 and miR-320a) in human follicular fluid from 91 women with normal ovarian reserve and 30 with polycystic ovary syndrome (PCOS) and their ability to predict IVF outcomes...
2016: Scientific Reports
keyword
keyword
86584
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"