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https://www.readbyqxmd.com/read/28198781/biomechanical-analysis-of-two-level-cervical-disc-replacement-with-a-stand-alone-u-shaped-disc-implant
#1
Yang Li, Guy R Fogel, Zhenhua Liao, Rajnesh Tyagi, Gaolong Zhang, Weiqiang Liu
STUDY DESIGN: Biomechanical study using a three-dimensional nonlinear finite element (FE) model. OBJECTIVE: To analyze biomechanical changes with three prostheses based on two-level arthroplasty and to verify the biomechanical efficiency of dynamic cervical implants (DCIs) with a stand-alone U-shaped structure. SUMMARY OF BACKGROUND DATA: Few studies have compared biomechanical behavior of various prostheses as they relate to clinical results after two-level total disc replacement (TDR)...
February 14, 2017: Spine
https://www.readbyqxmd.com/read/28178386/evaluating-a-dignity-care-intervention-for-palliative-care-in-the-community-setting-community-nurses-perspectives
#2
Sonja McIlfatrick, Michael Connolly, Rita Collins, Tara Murphy, Bridget Johnston, Philip Larkin
AIM AND OBJECTIVES: To evaluate a Dignity Care Intervention (DCI) provided by community nurses seeking to address dignity concerns for people with advanced and life limiting conditions BACKGROUND: Evidence would suggest that dying people fear a loss of dignity and a central focus of palliative care is to assist people to die with dignity. Whilst community nurses have a key role to play in the delivery of palliative care, specific interventions for dignity are lacking. DESIGN: A mixed methods study using online survey and focus group interviews and thematic analysis to examine data...
February 8, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28171804/hemodynamic-and-neuro-monitoring-for-neurocritically-ill-patients-an-international-survey-of-intensivists
#3
Sanjeev Sivakumar, Fabio S Taccone, Mohammed Rehman, Holly Hinson, Neeraj Naval, Christos Lazaridis
PURPOSE: To investigate multimodality systemic and neuro-monitoring practices in acute brain injury (ABI) and to analyze differences among "neurointensivists" (NI; clinical practice comprised >1/3 by neurocritical care), and other intensivists (OI). METHODS: Anonymous 22-question Web-based survey among physician members of SCCM and ESICM. RESULTS: Six hundred fifty-five responded (66% completion rate); 422 (65%) were OI, and 226 (35%) were NI...
January 21, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28169856/postinterventional-critical-care-management-of-aneurysmal-subarachnoid-hemorrhage
#4
Sudhir Datar, Alejandro A Rabinstein
PURPOSE OF REVIEW: Subarachnoid hemorrhage from a ruptured aneurysm (aSAH) is a complex disorder with the potential to have devastating effects on the brain as well as other organ systems. After more than 3 decades of research, the underlying pathophysiologic mechanisms remain incompletely understood and important questions remain regarding the evaluation and management of these patients. The purpose of this review is to analyze the recent literature and improve our understanding of certain key clinical aspects...
February 4, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28159246/low-concentration-of-sodium-bicarbonate-improves-the-bioactive-compound-levels-and-antioxidant-and-%C3%AE-glucosidase-inhibitory-activities-of-tartary-buckwheat-sprouts
#5
Peiyou Qin, Aichun Wei, Degang Zhao, Yang Yao, Xiushi Yang, Baoqing Dun, Guixing Ren
This study aimed to investigate the effects of different concentrations of sodium bicarbonate (NaHCO3) on the accumulation of flavonoids, total phenolics and d-chiro-inositol (DCI), as well as the antioxidant and α-glucosidase inhibitory activities, in tartary buckwheat sprouts. Treatment with low concentrations of NaHCO3 (0.05, 0.1, and 0.2%) resulted in an increase in flavonoids, total phenolic compounds and DCI concentrations, and improved DPPH radical-scavenging and α-glucosidase inhibition activities compared with the control (0%)...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28151871/antihypertensive-medications-and-risk-of-death-and-hospitalizations-in-us-hemodialysis-patients-evidence-from-a-cohort-study-to-inform-hypertension-treatment-practices
#6
Tariq Shafi, Stephen M Sozio, Jason Luly, Karen J Bandeen-Roche, Wendy L St Peter, Patti L Ephraim, Aidan McDermott, Charles A Herzog, Deidra C Crews, Julia J Scialla, Navdeep Tangri, Dana C Miskulin, Wieneke M Michels, Bernard G Jaar, Philip G Zager, Klemens B Meyer, Albert W Wu, L Ebony Boulware
Antihypertensive medications are commonly prescribed to hemodialysis patients but the optimal regimens to prevent morbidity and mortality are unknown. The goal of our study was to compare the association of routinely prescribed antihypertensive regimens with outcomes in US hemodialysis patients.We used 2 datasets for our analysis. Our primary cohort (US Renal Data System [USRDS]) included adult patients initiating in-center hemodialysis from July 1, 2006 to June 30, 2008 (n = 33,005) with follow-up through December 31, 2009...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28138916/a-systematic-and-meta-analysis-of-mortality-in-experimental-mouse-models-analyzing-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage
#7
Marcel A Kamp, Jasper H van Lieshout, Maxine Dibué-Adjei, Jasmin K Weber, Toni Schneider, Tanja Restin, Igor Fischer, Hans-Jakob Steiger
Animal models are established to display the pathophysiological changes following subarachnoid hemorrhage (SAH). The aim of the present study was to determine case fatality in mouse delayed cerebral ischemia (DCI) models, to compare mortality in mouse DCI models to case fatality in human SAH patients, and to identify factors influencing mouse mortality. A systematic search of the PubMed database was performed to identify all studies that assessed mouse DCI models. Mortality rates and predictor variables were extracted and compared to the human case fatality after SAH as previously reported...
January 30, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28113115/pcdd-fs-distribution-characteristics-and-health-risk-assessment-in-fly-ash-discharged-from-mswis-in-china
#8
Jie Sun, Juan Hu, Gengzheng Zhu, Dadang Zhang, Yuyi Zhu, Zhihai Chen, Jiafu Li, Hongjian Zhang, Jinshun Tang, Jihua Nie, Shuyu Zhang
This study provided distribution and health risk information of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in fly ash from 4 municipal solid waste incinerators (MSWIs) in four seasons from four sites, including Zhengzhou City in Henan Province, Chuzhou City in Anhui Province, Jilin City in Jilin Province and Zibo City in Shandong Province. The toxic equivalent concentration (I-TEQ) values of PCDD/Fs ranged from 0.0707 to 0.7742ng I-TEQ/g, and no identical sequence occurred during four seasons in different sampling sites...
January 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28093563/asymptomatic-mild-hyperperfusion-for-the-prediction-of-clinical-outcome-in-postoperative-patients-after-subarachnoid-hemorrhage
#9
Manabu Nakagawa, Tatsushi Mutoh, Shunsuke Takenaka, Tomoko Mutoh, Tomoko Totsune, Yasuyuki Taki, Tatsuya Ishikawa
BACKGROUND Delayed cerebral ischemia (DCI) is one of the main causes of poor outcomes after subarachnoid hemorrhage (SAH). The early identification of DCI by noninvasive imaging modalities would provide valuable information of therapeutic intervention for improving the patient outcomes. We aimed to describe the clinical features of cerebral blood flow (CBF) data obtained from the single-photon emission computed tomography (SPECT) during the risk period for DCI after SAH. MATERIAL AND METHODS Clinical data from 94 SAH patients who underwent surgical clipping of anterior circulation aneurysms were reviewed retrospectively...
January 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28087886/d-chiro-inositol-ameliorates-endothelial-dysfunction-via-inhibition-of-oxidative-stress-and-mitochondrial-fission
#10
Bobo Zhang, Xudan Guo, Yunlong Li, Qiang Peng, Jinfeng Gao, Baolin Liu, Min Wang
SCOPE: D-chiro inositol (DCI), an isomer of inositol, possesses anti-oxidative and endothelial protective properties. The mechanism by which DCI prevents endothelial dysfunction was investigated, with emphasis on oxidative stress. METHODS AND RESULTS: DCI was found to inhibit NOX4 induction and enhance Nrf2 activity in palmitate (PA)-stimulated cells, showing that DCI prevents oxidative stress. DCI suppressed Ser616 phosphorylation and increased Ser637 phosphorylation of Drp1 and inhibited PA-induced mitochondrial fission...
January 14, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28069456/neurocardiac-protection-with-milrinone-for-restoring-acute-cerebral-hypoperfusion-and-delayed-ischemic-injury-after-experimental-subarachnoid-hemorrhage
#11
Tomoko Mutoh, Tatsushi Mutoh, Kazumasu Sasaki, Kazuhiro Nakamura, Yasuko Tatewaki, Tatsuya Ishikawa, Yasuyuki Taki
BACKGROUND AND PURPOSE: Acute cerebral hypoperfusion following subarachnoid hemorrhage (SAH) is highly related to the pathogenesis of delayed cerebral ischemia (DCI), but the therapeutic option is poorly available. This study aimed to clarify the effect of milrinone (MIL) on cerebral blood flow (CBF) and related outcomes after experimental SAH. METHODS: Twenty-seven male C57BL/6 mice were assigned to either sham surgery (SAH-sham; n=6), SAH induced by endovascular perforation (control; n=10), or SAH followed by cardiac support with intravenous MIL (n=11) performed 1...
January 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28048633/tu-ab-202-08-generating-organ-surfaces-to-overcome-random-contouring-errors-and-slice-thickness-variations-on-multimodality-images
#12
S Oh, E Weiss, G Christensen, G Hugo, J Williamson
PURPOSE: To propose a new method that generates smooth organ surface meshes that overcomes random contouring errors and volume averaging artifacts for hollow organs. METHODS: The proposed contour-to-smooth mesh generation method (CSMG) consists of two parts; 1) reconstructing the inner and outer surfaces of the hollow organ with triangular meshes based on parametric active surface (PAS) and 2) modifying the reconstructed inner surface in order to satisfy minimum wall thickness constraints and matching the patient's known organ wall volume...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039583/a-pilot-study-of-d-chiro-inositol-plus-folic-acid-in-overweight-patients-with-type-1-diabetes
#13
Anna Rita Maurizi, Marika Menduni, Rossella Del Toro, Shadi Kyanvash, Daria Maggi, Chiara Guglielmi, Angelo Lauria Pantano, Giuseppe Defeudis, Elvira Fioriti, Silvia Manfrini, Paolo Pozzilli
AIMS: To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients. Similarly to metformin, D-chiro-inositol (DCI), as putative mediator of intracellular insulin action, can act as insulin sensitizer. The aim of this pilot study was to evaluate the hypothesis that DCI plus folic acid may improve glucose control reducing insulin resistance in overweight or obese T1D patients. METHODS: A 24-week randomized control trial was carried out in 26 overweight or obese T1D patients, undergoing intensive insulin therapy...
December 30, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/28028791/clinical-value-of-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio-after-aneurysmal-subarachnoid-hemorrhage
#14
Chuanyuan Tao, Jiajing Wang, Xin Hu, Junpeng Ma, Hao Li, Chao You
BACKGROUND: Inflammation and thrombosis are associated with the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH) and neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are emerging as novel inflammatory markers in stroke. We aimed to identify the association of NLR and PLR with delayed cerebral ischemia (DCI) and 3-month outcome after aSAH. METHODS: Two hundred and forty-seven patients diagnosed with aSAH within 24 h of symptoms onset were enrolled...
December 27, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/28028564/evolution-of-diffusion-tensor-imaging-parameters-after-acute-subarachnoid-haemorrhage-a-prospective-cohort-study
#15
Isabel Fragata, Patrícia Canhão, Marta Alves, Ana Luísa Papoila, Nuno Canto-Moreira
INTRODUCTION: Few studies assessed diffusion tensor imaging (DTI) changes in the acute phase of subarachnoid haemorrhage (SAH). We prospectively evaluated DTI parameters in the acute phase of SAH and 8-10 days after and analysed whether changes could be related to SAH severity or to the development of delayed cerebral ischemia (DCI). METHODS: Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) changes over time were assessed in a prospective cohort of patients with acute SAH...
January 2017: Neuroradiology
https://www.readbyqxmd.com/read/28017781/inotropic-support-against-early-brain-injury-improves-cerebral-hypoperfusion-and-outcomes-in-a-murine-model-of-subarachnoid-hemorrhage
#16
Tomoko Mutoh, Tatsushi Mutoh, Kazuhiro Nakamura, Kazumasu Sasaki, Yasuko Tatewaki, Tatsuya Ishikawa, Yasuyuki Taki
Early brain injury/ischemia is a recent therapeutic target that contributes to triggering delayed cerebral ischemia (DCI) in the setting of subarachnoid hemorrhage (SAH). This study aimed to determine the role of dobutamine for inotropic cardiac support in improving cerebral blood flow (CBF) and outcomes after experimental SAH, mediated by hypoxia-inducible factor (HIF). Thirty-one mice were subjected to SAH by endovascular perforation, and assigned to either 2% isoflurane postconditioning performed between 1 and 2...
December 23, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/28008646/acute-cardiac-support-with-intravenous-milrinone-promotes-recovery-from-early-brain-injury-in-a-murine-model-of-severe-subarachnoid-hemorrhage
#17
Tomoko Mutoh, Tatsushi Mutoh, Kazuhiro Nakamura, Yukiko Yamamoto, Yoshiharu Tsuru, Hirokazu Tsubone, Tatsuya Ishikawa, Yasuyuki Taki
Early brain injury/ischemia (EBI) is a serious complication early after subarachnoid hemorrhage (SAH) that contributes to development of delayed cerebral ischemia (DCI). This study aimed to determine the role of inotropic cardiac support using milrinone (MIL) on restoring acute cerebral hypoperfusion attributable to EBI and improving outcomes after experimental SAH. Forty-three male C57BL/6 mice were assigned to either sham surgery (SAH-sham), SAH induced by endovascular perforation plus postconditioning with 2% isoflurane (Control), or SAH plus isoflurane combined with MIL with and without hypoxia-inducible factor inhibitor (HIF-I) pretreatment...
December 23, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28000132/biomarkers-of-glycocalyx-injury-are-associated-with-delayed-cerebral-ischemia-following-aneurysmal-subarachnoid-hemorrhage-a-case-series-supporting-a-new-hypothesis
#18
Josh D Bell, Shawn G Rhind, Alex P Di Battista, R Loch Macdonald, Andrew J Baker
BACKGROUND: Delayed cerebral ischemia (DCI) contributes to morbidity following aneurysmal subarachnoid hemorrhage; however, its etiology remains poorly understood. DCI is not only a consequence of angiographic vasospasm, but also involves microthrombosis and neuroinflammation, two events with unexplained phenomenology. The vascular endothelial glycocalyx mediates platelet aggregation and endothelial cell-leukocyte interactions and may play an important role in DCI pathogenesis. METHODS: We present a case series in which we conducted multiplex and singlet enzyme-linked immunosorbent assays of endothelial, glycocalyx, inflammatory, and neuroinjury proteins in both CSF and plasma in three patients during active DCI following SAH...
December 20, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27987096/associations-between-dyadic-coping-and-supportive-care-needs-findings-from-a-study-with-hematologic-cancer-patients-and-their-partners
#19
Gregor Weißflog, Klaus Hönig, Harald Gündel, Dirk Lang, Dietger Niederwieser, Hartmut Döhner, Martin Vogelhuber, Anja Mehnert, Jochen Ernst
PURPOSE: The way couples mutually cope with hematologic cancer is likely to influence their levels of supportive care needs (SCN). Therefore, this study evaluated the levels of dyadic coping (DC) and SCN and the concurrent associations between both variables. METHODS: Three hundred thirty patients with a hematologic malignancy (63% male) and their partners completed the dyadic coping inventory (DCI) and the supportive care needs survey (SCNS-SF-34-G). The levels of dyadic coping (DC) and supportive care needs (SCN) were compared with representative validation samples...
December 16, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27935361/acute-impairment-of-saccadic-eye-movements-is-associated-with-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#20
Matthew J Rowland, Payashi Garry, Jon Westbrook, Rufus Corkill, Chrystalina A Antoniades, Kyle T S Pattinson
OBJECTIVE Delayed cerebral ischemia (DCI) causing cerebral infarction remains a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Early brain injury in the first 72 hours following rupture is likely to play a key role in the pathophysiology underlying DCI but remains difficult to quantify objectively. Current diagnostic modalities are based on the concept of vasoconstriction causing cerebral ischemia and infarction and are either invasive or have a steep learning curve and user variability...
December 9, 2016: Journal of Neurosurgery
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