keyword
MENU ▼
Read by QxMD icon Read
search

Hyperactive adrenal

keyword
https://www.readbyqxmd.com/read/28341321/reprint-of-repeated-adolescent-activity-based-anorexia-influences-central-estrogen-signaling-and-adulthood-anxiety-like-behaviors-in-rats
#1
Tien-Jui Lee, Kimberly P Kinzig
Anorexia nervosa (AN) typically presents in adolescence and is highly comorbid with anxiety and depression, which often persist after elimination of AN symptomology. The activity-based anorexia (ABA) paradigm allows for evaluation of behavioral and neuroendocrine consequences of AN-like behaviors, including voluntary anorexia, hyperactivity, and disruption of the hypothalamic-pituitary-gonadal (HPG) and the hypothalamic pituitary adrenal (HPA) axis. Because ABA in adolescent females results in increased anxiety-like behavior in adulthood and the estrogen signaling system has been shown to play a role in anxiety and food intake, we investigated the role of ovarian hormones in adolescent ABA-treated rats, and long-term effects of mid- and late adolescent ABA exposure on behavior and estrogen signaling...
March 21, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28282447/neonatal-overfeeding-disrupts-pituitary-ghrelin-signalling-in-female-rats-long-term-implications-for-the-stress-response
#2
Luba Sominsky, Ilvana Ziko, Sarah J Spencer
The hypothalamic-pituitary-adrenal (HPA) axis responses to psychological stress are exacerbated in adult female but not male rats made obese due to overfeeding in early life. Ghrelin, traditionally known for its role in energy homeostasis, has been recently recognised for its role in coordinating the HPA responses to stress, particularly by acting directly at the anterior pituitary where the growth hormone secretagogue receptor (GHSR), the receptor for acyl ghrelin, is abundantly expressed. We therefore hypothesised that neonatal overfeeding in female rats would compromise pituitary responsiveness to ghrelin, contributing to a hyperactive central stress responsiveness...
2017: PloS One
https://www.readbyqxmd.com/read/28264636/mothers-parenting-stress-is-associated-with-salivary-cortisol-profiles-in-children-with-attention-deficit-hyperactivity-disorder
#3
Terpsichori Korpa, Panagiota Pervanidou, Eleni Angeli, Filia Apostolakou, Katerina Papanikolaou, Ioannis Papassotiriou, George P Chrousos, Gerasimos Kolaitis
The aim of this study was to explore the relation between mothers' parenting stress and the functioning of the hypothalamic-pituitary-adrenal axis (HPAA), as expressed by daily salivary cortisol concentrations, in their children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Seventy-five children aged 6-11 years diagnosed with ADHD predominant Hyperactive-Impulsive/Combined (ADHD-HI/C, N = 49) and Inattentive symptoms (ADHD-I, N = 26) and 45 healthy peers and their mothers participated in the study...
March 6, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28263537/chronic-unpredictable-mild-stress-paradigm-in-male-wistar-rats-effect-on-anxiety-and-depressive-like-behavior
#4
Romana Koprdova, Eszter Bögi, Kristína Belovičová, Natália Sedláčková, Monika Okuliarová, Eduard Ujházy, Mojmír Mach
OBJECTIVES: There are several models of depression. Chronic unpredictable mild stress (CMS) appears to have the greatest validity, although it is often being criticized for low reliability. METHODS: Male Wistar/DV rats were used in this study to assess our modified 2-week model of CMS as a combination of psychosocial, physical and metabolic stressors and to compare the effect of acute administration of venlafaxine (VFX) and diazepam (DZP), either in stress or no stress conditions...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28259860/potential-salivary-biomarkers-and-their-genetic-effects-in-a-pilot-study-of-adolescent-boys-with-externalizing-problems
#5
Nora Angyal, Jozsef Halasz, Gergely Meszaros, Judit Krisztina Kovacs, Emese Kruk, Zsofia Nemoda
AIMS: Beside the well-known stress response marker cortisol, salivary alpha-amylase is receiving increasing attention. Numerous studies have investigated the potential biomarker properties of cortisol mirroring abnormal hypothalamic-pituitary-adrenal axis activity in connection to both internalizing and externalizing behavior problems. The other major physiological system involved in stress reactivity, the sympathetic nervous system activity can be also measured by the surrogate marker of salivary alpha-amylase...
December 2016: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28249186/attention-deficit-hyperactivity-disorder-symptoms-and-stress-related-biomarkers
#6
S W N Vogel, D Bijlenga, J Verduijn, T I Bron, A T F Beekman, J J S Kooij, B W J H Penninx
OBJECTIVE: The current study examined whether (a) Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms were associated with dysregulation of stress-related mechanisms, and (b) whether ADHD symptoms interact with affective disorders in their association with dysregulated stress-related mechanisms. METHODS: Data were obtained from 2307 subjects participating in the Netherlands Study of Depression and Anxiety. Stress-related mechanisms were reflected by the following biomarkers: (1) hypothalamic-pituitary-adrenal axis indicators (salivary cortisol awakening curve, evening cortisol, cortisol suppression after a 0...
February 13, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28237543/hyper-and-hypocortisolism-in-bipolar-disorder-a-beneficial-influence-of-lithium-on-the-hpa-axis
#7
Martin Maripuu, Mikael Wikgren, Pontus Karling, Rolf Adolfsson, Karl-Fredrik Norrback
BACKGROUND: A hyperactive hypothalamic-pituitary-adrenal axis (HPA-axis) is a well-known phenomenon in bipolar disorder (BD). However, hypocortisolism has also been described and found associated with depression, low quality of life and cardiovascular risk factors in BD patients. Although the pathophysiology related to hypocortisolism in BD is largely unknown, hypocortisolism is associated with chronic stress exposure and after inducing an initial rise in cortisol long-term stress may result in a transition to hypocortisolism...
February 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28168960/sex-specific-neurodevelopmental-programming-by-placental-insulin-receptors-on-stress-reactivity-and-sensorimotor-gating
#8
Stefanie L Bronson, Jennifer C Chan, Tracy L Bale
BACKGROUND: Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear. Because defective placental insulin receptor (InsR) signaling is a hallmark of pregnancy metabolic dysfunction, we hypothesized that it may be an important contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disease risk...
December 30, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28142338/toxicity-assessment-of-molindone-hydrochloride-a-dopamine-d2-d5-receptor-antagonist-in-juvenile-and-adult-rats
#9
Gopala Krishna, Gopa Gopalakrishnan, Saryu Goel
Neuroleptic drug molindone hydrochloride is a dopamine D2/D5 receptor antagonist and it is in late stage development for the treatment of impulsive aggression in children and adolescents who have attention deficient/hyperactivity disorder (ADHD). This new indication for this drug would expand the target population to include younger patients, and therefore, toxicity assessments in juvenile animals were undertaken in order to determine susceptibility differences, if any, between this age group and the adult rats...
January 31, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28126450/piper-sarmentosum-roxb-produces-antidepressant-like-effects-in-rodents-associated-with-activation-of-the-creb-bdnf-erk-signalling-pathway-and-reversal-of-hpa-axis-hyperactivity
#10
Qing Li, Fa-Lin Qu, Yue Gao, Yi-Ping Jiang, Khalid Rahman, Kuo-Hsiung Lee, Ting Han, Lu-Ping Qin
ETHNOPHARMACOLOGICAL RELEVANCE: There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. MATERIALS AND METHODS: In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice...
January 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28042822/enduring-sexually-dimorphic-impact-of-in-utero-exposure-to-elevated-levels-of-glucocorticoids-on-midbrain-dopaminergic-populations
#11
REVIEW
Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalley
Glucocorticoid hormones (GCs) released from the fetal/maternal glands during late gestation are required for normal development of mammalian organs and tissues. Accordingly, synthetic glucocorticoids have proven to be invaluable in perinatal medicine where they are widely used to accelerate fetal lung maturation when there is risk of pre-term birth and to promote infant survival. However, clinical and pre-clinical studies have demonstrated that inappropriate exposure of the developing brain to elevated levels of GCs, either as a result of clinical over-use or after stress-induced activation of the fetal/maternal adrenal cortex, is linked with significant effects on brain structure, neurological function and behaviour in later life...
December 30, 2016: Brain Sciences
https://www.readbyqxmd.com/read/28024269/aromatase-changes-in-depression-a-postmortem-and-animal-experimental-study
#12
Juan-Li Wu, Yang He, Radovan Hrubý, Rawien Balesar, Yang-Jian Qi, Lei Guo, Zhong Ren, Qiong-Bin Zhu, Man-Li Huang, Dick F Swaab, Ai-Min Bao
A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27922635/increased-plasma-levels-of-circulating-cell-free-mitochondrial-dna-in-suicide-attempters-associations-with-hpa-axis-hyperactivity
#13
D Lindqvist, J Fernström, C Grudet, L Ljunggren, L Träskman-Bendz, L Ohlsson, Å Westrin
Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the bloodstream. Major depressive disorder has been associated with an increased amount of mtDNA in leukocytes from saliva samples and blood; however, no previous studies have measured plasma levels of free-circulating mtDNA in a clinical psychiatric sample. In this study, free circulating mtDNA was quantified in plasma samples from 37 suicide attempters, who had undergone a dexamethasone suppression test (DST), and 37 healthy controls...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27901414/cognitive-deficits-and-inflammatory-response-resulting-from-mild-to-moderate-traumatic-brain-injury-in-rats-are-exacerbated-by-repeated-pre-exposure-to-an-innate-stress-stimulus
#14
Michaël Ogier, Amor Belmeguenai, Thomas Lieutaud, Béatrice Georges, Sandrine Bouvard, Emilie Carré, Frédéric Canini, Laurent Bezin
Traumatic brain injury (TBI) is common in both military and civilian populations, and often results in neurobehavioral sequelae that impair quality of life in both patients and their families. Although individuals who are chronically exposed to stress are more likely to experience TBI, it is still unknown whether pre-injury stress influences the outcome after TBI. The present study tested whether behavioral and cognitive long-term outcome after TBI in rats is affected by prior exposure to an innate stress stimulus...
January 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27766083/behavioral-neuroadaptation-to-alcohol-from-glucocorticoids-to-histone-acetylation
#15
Nicole Mons, Daniel Beracochea
A prime mechanism that contributes to the development and maintenance of alcoholism is the dysregulation of the hypothalamic-pituitary-adrenal axis activity and the release of glucocorticoids (cortisol in humans and primates, corticosterone in rodents) from the adrenal glands. In the brain, sustained, local elevation of glucocorticoid concentration even long after cessation of chronic alcohol consumption compromises functional integrity of a circuit, including the prefrontal cortex (PFC), the hippocampus (HPC), and the amygdala (AMG)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27746334/antidepressant-like-effects-of-xiaochaihutang-in-a-neuroendocrine-mouse-model-of-anxiety-depression
#16
Kuo Zhang, Jingyu Yang, Fang Wang, Xing Pan, Jian Liu, Lijuan Wang, Guangyue Su, Jie Ma, Yingxu Dong, Zhili Xiong, Chunfu Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis is often observed in the pathophysiology of depression. Antidepressant therapy can restore hippocampal neurogenesis to rescue the HPA axis regulation defects. Xiaochaihutang (XCHT), a famous Chinese herbal formula, has been used clinically in depressive disorders in China. Our previous studies have demonstrated XCHT improved depressive-like behaviors in chronic unpredictable mild stress rat, but the underlying mechanisms of XCHT on hippocampal neurogenesis and the HPA axis were still unclear...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27741480/glucocorticoid-receptor-variants-in-childhood-attention-deficit-hyperactivity-disorder-and-comorbid-psychiatric-disorders
#17
Andrea B Schote, Martina Bonenberger, Haukur Pálmason, Christiane Seitz, Jobst Meyer, Christine M Freitag
Stress results in a variety of neuroendocrine, immune and behavioral responses and represents a risk factor for many disorders. Following exposure to stress, glucocorticoids are secreted from the adrenal cortex and act via the ligand-activated glucocorticoid receptor (GR). Several polymorphisms of the GR-encoding gene NR3C1 have been described and functionally investigated. However, the impact of these variants on complex diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD) is still unclear. In this study, 251 children with ADHD, 19 affected and 35 unaffected siblings, and their parents were included in a family-based association study assessing seven common variants of NR3C1 (TthIIII_rs10052957; NR3C1-I_rs10482605; ER22/23EK_rs6189/rs6190; N363S_rs56149945; BclI_rs41423247; GR-9beta_rs6198)...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27738546/mini-review-anticholinergic-activity-as-a-behavioral-pathology-of-lewy-body-disease-and-proposal-of-the-concept-of-anticholinergic-spectrum-disorders
#18
REVIEW
Koji Hori, Kimiko Konishi, Misa Hosoi, Hiroi Tomioka, Masayuki Tani, Yuka Kitajima, Mitsugu Hachisu
Given the relationship between anticholinergic activity (AA) and Alzheimer's disease (AD), we rereview our hypothesis of the endogenous appearance of AA in AD. Briefly, because acetylcholine (ACh) regulates not only cognitive function but also the inflammatory system, when ACh downregulation reaches a critical level, inflammation increases, triggering the appearance of cytokines with AA. Moreover, based on a case report of a patient with mild AD and slightly deteriorated ACh, we also speculate that AA can appear endogenously in Lewy body disease due to the dual action of the downregulation of ACh and hyperactivity of the hypothalamic-pituitary-adrenal axis...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27729464/prepuberal-light-phase-feeding-induces-neuroendocrine-alterations-in-adult-rats
#19
C García-Luna, P Soberanes-Chávez, P de Gortari
Feeding patterns are important factors in obesity evolvement. Time-restricted feeding schedules (tRF) during resting phase change energy homeostasis regulation, disrupting the circadian release of metabolism-regulating hormones, such as leptin, insulin and corticosterone and promoting body weight gain. Thyroid (HPT) and adrenal (HPA) axes exhibit a circadian regulation and are involved in energy expenditure, thus studying their parameters in tRF paradigms will elucidate their role in energy homeostasis impairments under such conditions...
January 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27725421/impact-of-maternal-stress-in-pregnancy-on-brain-function-of-the-offspring
#20
Jun Udagawa, Kodai Hino
Epidemiological studies suggest that exposure to prenatal stressors, including malnutrition, maternal immune activation (MIA), and adverse life events, is associated with increased risks of schizophrenia, autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD). However, the underlying pathophysiological mechanisms are unclear. The first trimester of pregnancy is particularly a vulnerable period. During this period, the self-renewal of neural stem cells and neurogenesis vigorously occur, and synaptic connections are partially formed in the telencephalon...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
keyword
keyword
86573
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"